locus-tag	class	description
E3S63_00020	COG0740	serine-type endopeptidase activity
E3S63_00070	COG0739	heme binding
E3S63_00120	COG1388	LysM domain
E3S63_00120	COG5632	N-Acetylmuramoyl-L-alanine amidase
E3S63_00185	COG1725	Transcriptional regulator
E3S63_00200	COG1131	(ABC) transporter
E3S63_00255	COG1012	belongs to the aldehyde dehydrogenase family
E3S63_00270	COG1335	isochorismatase
E3S63_00280	COG0471	metal ion transport
E3S63_00290	COG0077	Prephenate dehydratase
E3S63_00300	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E3S63_00335	COG4496	protein, YerC YecD
E3S63_00355	COG4851	CamS sex pheromone cAM373 precursor
E3S63_00470	COG1295	ribonuclease BN
E3S63_00490	COG2309	aminopeptidase activity
E3S63_00495	COG1607	acyl-coa hydrolase
E3S63_00500	COG0535	radical SAM domain protein
E3S63_00530	COG1134	teichoic acid transport
E3S63_00530	COG1388	LysM domain
E3S63_00540	COG1988	membrane-bound metal-dependent
E3S63_00565	COG4129	membrane
E3S63_00575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E3S63_00580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3S63_00755	COG0765	amino acid transport
E3S63_00760	COG1126	abc transporter atp-binding protein
E3S63_00765	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E3S63_00795	COG0564	pseudouridine synthase activity
E3S63_00800	COG2203	Gaf domain
E3S63_00800	COG4585	Histidine kinase
E3S63_00805	COG2197	response regulator
E3S63_00830	COG0420	3'-5' exonuclease activity
E3S63_00860	COG0537	adenosine 5'-monophosphoramidase activity
E3S63_00865	COG1131	(ABC) transporter
E3S63_01140	COG2816	NAD+ diphosphatase activity
E3S63_01145	COG1506	peptidase
E3S63_01165	COG0656	L-ascorbic acid biosynthetic process
E3S63_01190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3S63_01220	COG3266	domain, Protein
E3S63_01220	COG5632	N-Acetylmuramoyl-L-alanine amidase
E3S63_01220	COG4193	domain, Protein
E3S63_01240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3S63_01240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3S63_01270	COG2267	carboxylic ester hydrolase activity
E3S63_01280	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E3S63_01285	COG1242	4 iron, 4 sulfur cluster binding
E3S63_01290	COG2814	Major facilitator Superfamily
E3S63_01310	COG2081	HI0933 family
E3S63_01315	COG2244	polysaccharide biosynthetic process
E3S63_01320	COG1187	pseudouridine synthase activity
E3S63_01340	COG0510	thiamine kinase activity
E3S63_01350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3S63_01360	COG1363	Peptidase, m42
E3S63_01365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3S63_01375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3S63_01380	COG1674	ftsk spoiiie
E3S63_01405	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E3S63_01405	COG1605	Chorismate mutase
E3S63_01425	COG0454	-acetyltransferase
E3S63_01430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3S63_01465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3S63_01470	COG0204	Acyl-transferase
E3S63_01475	COG1263	PTS System
E3S63_01475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S63_01490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3S63_01495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E3S63_01500	COG1764	response to oxidative stress
E3S63_01505	COG0584	glycerophosphoryl diester phosphodiesterase
E3S63_01520	COG1956	GAF domain-containing protein
E3S63_01535	COG1104	cysteine desulfurase activity
E3S63_01545	COG0730	response to heat
E3S63_01555	COG0827	DNA restriction-modification system
E3S63_01595	COG4109	DRTGG domain
E3S63_01600	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E3S63_01610	COG0281	malic enzyme
E3S63_01635	COG1113	amino acid transport
E3S63_01640	COG0372	Belongs to the citrate synthase family
E3S63_01650	COG0745	RESPONSE REGULATOR receiver
E3S63_01655	COG5002	protein histidine kinase activity
E3S63_01665	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3S63_01665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3S63_01695	COG1484	DNA-dependent DNA replication
E3S63_01710	COG0833	amino acid
E3S63_01730	COG4112	unkown
E3S63_01765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3S63_01800	COG2818	Glycosylase
E3S63_01810	COG0285	dihydrofolate synthase activity
E3S63_01815	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E3S63_01855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3S63_01900	COG2868	ribosomal protein
E3S63_01940	COG1862	Preprotein translocase
E3S63_01945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3S63_01945	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3S63_01950	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E3S63_01950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E3S63_01995	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E3S63_02000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3S63_02005	COG1959	2 iron, 2 sulfur cluster binding
E3S63_02010	COG3237	CsbD-like
E3S63_02020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3S63_02025	COG1104	cysteine desulfurase activity
E3S63_02040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3S63_02090	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E3S63_02095	COG1984	allophanate hydrolase subunit 2
E3S63_02100	COG0511	ligase activity, forming carbon-carbon bonds
E3S63_02105	COG0439	Biotin carboxylase
E3S63_02115	COG1914	H( )-stimulated, divalent metal cation uptake system
E3S63_02120	COG3177	Filamentation induced by cAMP protein fic
E3S63_02140	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
E3S63_02145	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E3S63_02155	COG1534	Rna-binding protein
E3S63_02165	COG1713	HD superfamily hydrolase involved in NAD metabolism
E3S63_02170	COG0799	negative regulation of ribosome biogenesis
E3S63_02175	COG2226	methyltransferase
E3S63_02180	COG2183	response to ionizing radiation
E3S63_02185	COG2131	deaminase
E3S63_02190	COG0658	competence protein
E3S63_02190	COG2333	competence protein COMEC
E3S63_02195	COG1466	dna polymerase III delta subunit
E3S63_02210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3S63_02240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E3S63_02245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3S63_02255	COG1030	water channel activity
E3S63_02270	COG1702	phosphate starvation-inducible protein PhoH
E3S63_02285	COG0295	cytidine deaminase activity
E3S63_02305	COG0517	IMP dehydrogenase activity
E3S63_02325	COG2384	SAM-dependent methyltransferase
E3S63_02335	COG0513	Belongs to the DEAD box helicase family
E3S63_02345	COG1121	(ABC) transporter
E3S63_02350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3S63_02375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E3S63_02385	COG4483	Protein conserved in bacteria
E3S63_02390	COG1940	carbohydrate kinase activity
E3S63_02395	COG0011	TIGRFAM Protein of
E3S63_02400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3S63_02405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3S63_02410	COG1459	type II secretion system
E3S63_02415	COG4537	Required for transformation and DNA binding
E3S63_02460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3S63_02465	COG0095	Lipoate-protein ligase
E3S63_02480	COG0006	proline dipeptidase activity
E3S63_02490	COG0511	ligase activity, forming carbon-carbon bonds
E3S63_02495	COG0439	Biotin carboxylase
E3S63_02500	COG1302	Protein conserved in bacteria
E3S63_02530	COG0497	DNA recombination
E3S63_02535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3S63_02540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E3S63_02545	COG0022	dehydrogenase e1 component
E3S63_02550	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3S63_02560	COG4129	membrane
E3S63_02570	COG2195	Cleaves the N-terminal amino acid of tripeptides
E3S63_02595	COG1609	Transcriptional regulator
E3S63_02600	COG0366	Alpha amylase catalytic
E3S63_02610	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E3S63_02625	COG4221	oxidoreductase activity
E3S63_02635	COG0667	Aldo Keto reductase
E3S63_02640	COG0494	nUDIX hydrolase
E3S63_02645	COG0735	belongs to the Fur family
E3S63_02670	COG1187	pseudouridine synthase activity
E3S63_02675	COG0745	RESPONSE REGULATOR receiver
E3S63_02720	COG1141	Ferredoxin
E3S63_02730	COG0514	ATP-dependent DNA helicase (RecQ)
E3S63_02745	COG0492	ferredoxin-NADP+ reductase activity
E3S63_02800	COG0142	geranyltranstransferase activity
E3S63_02840	COG4347	Protein of unknown function (DUF1405)
E3S63_02845	COG2738	Putative neutral zinc metallopeptidase
E3S63_02850	COG1694	Mazg nucleotide pyrophosphohydrolase
E3S63_02855	COG0438	transferase activity, transferring glycosyl groups
E3S63_02880	COG3935	DnaD domain protein
E3S63_02885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3S63_02895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3S63_02895	COG4499	WXG100 protein secretion system (Wss), protein YukC
E3S63_02930	COG0116	Belongs to the methyltransferase superfamily
E3S63_02945	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E3S63_02950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3S63_02965	COG0531	amino acid
E3S63_02985	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E3S63_03060	COG0671	phosphoesterase, PA-phosphatase related
E3S63_03105	COG0714	Associated with various cellular activities
E3S63_03110	COG4548	von Willebrand factor, type A
E3S63_03180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3S63_03185	COG0527	aspartate kinase activity
E3S63_03190	COG0488	(ABC) transporter
E3S63_03210	COG0573	inorganic phosphate transmembrane transporter activity
E3S63_03215	COG0581	inorganic phosphate transmembrane transporter activity
E3S63_03225	COG0704	Plays a role in the regulation of phosphate uptake
E3S63_03315	COG0512	Glutamine amidotransferase of anthranilate synthase
E3S63_03320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3S63_03325	COG1363	Peptidase, m42
E3S63_03335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3S63_03360	COG0628	permease
E3S63_03375	COG1115	amino acid carrier protein
E3S63_03400	COG0824	Thioesterase
E3S63_03410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3S63_03430	COG4846	Membrane protein involved in cytochrome C biogenesis
E3S63_03465	COG2340	Cysteine-rich secretory protein family
E3S63_03495	COG0833	amino acid
E3S63_03520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E3S63_03525	COG0460	homoserine dehydrogenase
E3S63_03530	COG0527	aspartate kinase activity
E3S63_03545	COG1525	nuclease
E3S63_03555	COG2197	response regulator
E3S63_03650	COG0789	Transcriptional regulator
E3S63_03655	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
E3S63_03660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3S63_03670	COG1923	regulation of RNA biosynthetic process
E3S63_03695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E3S63_03700	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E3S63_03735	COG1013	pyruvate-flavodoxin oxidoreductase activity
E3S63_03740	COG0674	pyruvate-flavodoxin oxidoreductase activity
E3S63_03740	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E3S63_03745	COG1692	metallophosphoesterase
E3S63_03765	COG1546	Belongs to the CinA family
E3S63_03765	COG1058	Belongs to the CinA family
E3S63_03785	COG0300	oxidoreductase activity
E3S63_03790	COG0612	Peptidase, M16
E3S63_03795	COG0612	Peptidase, M16
E3S63_03800	COG2188	Transcriptional regulator
E3S63_03825	COG0196	riboflavin kinase activity
E3S63_03850	COG2740	Nucleic-acid-binding protein implicated in transcription termination
E3S63_03855	COG0195	Participates in both transcription termination and antitermination
E3S63_03955	COG2348	transferase activity, transferring amino-acyl groups
E3S63_04010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3S63_04020	COG0552	protein localization to endoplasmic reticulum
E3S63_04025	COG1196	nuclear chromosome segregation
E3S63_04070	COG1302	Protein conserved in bacteria
E3S63_04085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3S63_04100	COG0631	protein serine/threonine phosphatase activity
E3S63_04110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3S63_04110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E3S63_04125	COG2314	TM2 domain
E3S63_04135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E3S63_04140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3S63_04155	COG1293	RNA-binding protein homologous to eukaryotic snRNP
E3S63_04200	COG2233	PERMEase
E3S63_04210	COG0564	pseudouridine synthase activity
E3S63_04225	COG2514	catechol 2,3-dioxygenase activity
E3S63_04235	COG3599	regulation of cell shape
E3S63_04240	COG2302	S4 RNA-binding domain
E3S63_04245	COG0762	integral membrane protein
E3S63_04255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E3S63_04270	COG0849	cell division
E3S63_04275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E3S63_04295	COG4839	cell division protein FtsL
E3S63_04320	COG1011	Hydrolase
E3S63_04355	COG1288	antiporter activity
E3S63_04465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E3S63_04470	COG1053	succinate dehydrogenase
E3S63_04475	COG2009	succinate dehydrogenase
E3S63_04500	COG1796	DNA polymerase
E3S63_04500	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E3S63_04530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3S63_04545	COG4509	Sortase family
E3S63_04600	COG0742	ribosomal rna small subunit methyltransferase
E3S63_04620	COG3679	Belongs to the UPF0342 family
E3S63_04650	COG0772	Belongs to the SEDS family
E3S63_04660	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E3S63_04680	COG0483	inositol monophosphate 1-phosphatase activity
E3S63_04705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E3S63_04710	COG1177	transmembrane transport
E3S63_04715	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3S63_04780	COG0569	domain protein
E3S63_04785	COG1294	oxidase, subunit
E3S63_04790	COG1271	oxidase subunit
E3S63_04795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3S63_04815	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E3S63_04835	COG4721	ABC-type cobalt transport system, permease component
E3S63_04840	COG4172	Belongs to the ABC transporter superfamily
E3S63_04845	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E3S63_04885	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3S63_04900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E3S63_04945	COG1316	TRANSCRIPTIONal
E3S63_04975	COG3594	Acyltransferase
E3S63_04980	COG0436	Aminotransferase
E3S63_05005	COG2267	carboxylic ester hydrolase activity
E3S63_05015	COG1169	isochorismate synthase
E3S63_05025	COG1575	Belongs to the MenA family. Type 1 subfamily
E3S63_05030	COG0456	acetyltransferase
E3S63_05035	COG2314	TM2 domain
E3S63_05045	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E3S63_05100	COG4873	Protein conserved in bacteria
E3S63_05115	COG4903	ComK protein
E3S63_05130	COG0737	Belongs to the 5'-nucleotidase family
E3S63_05135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3S63_05145	COG0861	Integral membrane protein TerC family
E3S63_05185	COG1115	amino acid carrier protein
E3S63_05190	COG0628	permease
E3S63_05200	COG0475	glutathione-regulated potassium exporter activity
E3S63_05200	COG0569	domain protein
E3S63_05205	COG2239	Acts as a magnesium transporter
E3S63_05210	COG0564	pseudouridine synthase activity
E3S63_05220	COG2357	RelA SpoT domain protein
E3S63_05235	COG2346	COG2346, Truncated hemoglobins
E3S63_05245	COG1164	Oligoendopeptidase f
E3S63_05270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3S63_05275	COG0601	transmembrane transport
E3S63_05280	COG4608	Belongs to the ABC transporter superfamily
E3S63_05285	COG0444	Belongs to the ABC transporter superfamily
E3S63_05290	COG0747	negative chemotaxis
E3S63_05295	COG4166	transmembrane transport
E3S63_05300	COG4608	Belongs to the ABC transporter superfamily
E3S63_05305	COG0444	Belongs to the ABC transporter superfamily
E3S63_05310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3S63_05315	COG0601	transmembrane transport
E3S63_05345	COG1881	PFAM PEBP family protein
E3S63_05360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E3S63_05385	COG0561	phosphatase activity
E3S63_05425	COG0398	Pfam SNARE associated Golgi protein
E3S63_05445	COG0584	glycerophosphoryl diester phosphodiesterase
E3S63_05460	COG1902	pentaerythritol trinitrate reductase activity
E3S63_05465	COG1098	S1 RNA binding domain
E3S63_05520	COG2050	protein possibly involved in aromatic compounds catabolism
E3S63_05525	COG2056	Na+-H+ antiporter family
E3S63_05530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3S63_05540	COG0316	Belongs to the HesB IscA family
E3S63_05550	COG1252	NADH dehydrogenase
E3S63_05555	COG4837	Protein of unknown function (DUF1462)
E3S63_05560	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E3S63_05565	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
E3S63_05575	COG1696	Membrane protein involved in D-alanine export
E3S63_05605	COG2445	Protein of unknown function DUF86
E3S63_05620	COG4470	Protein conserved in bacteria
E3S63_05635	COG0730	response to heat
E3S63_05640	COG1801	Protein of unknown function DUF72
E3S63_05655	COG1253	flavin adenine dinucleotide binding
E3S63_05690	COG1388	LysM domain
E3S63_05690	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3S63_05920	COG1484	DNA-dependent DNA replication
E3S63_05995	COG1396	sequence-specific DNA binding
E3S63_06030	COG0822	iron-sulfur transferase activity
E3S63_06040	COG0719	Fe-S assembly protein
E3S63_06045	COG0396	ATPase activity
E3S63_06060	COG1464	Belongs to the NlpA lipoprotein family
E3S63_06065	COG2011	ABC-type metal ion transport system permease component
E3S63_06080	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E3S63_06085	COG3878	Protein conserved in bacteria
E3S63_06100	COG1393	Belongs to the ArsC family
E3S63_06105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3S63_06130	COG1279	arginine transmembrane transporter activity
E3S63_06135	COG0406	alpha-ribazole phosphatase activity
E3S63_06175	COG1278	Cold shock
E3S63_06245	COG0557	exoribonuclease II activity
E3S63_06250	COG1647	Serine aminopeptidase, S33
E3S63_06255	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3S63_06315	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E3S63_06370	COG1388	LysM domain
E3S63_06370	COG3942	CHAP domain
E3S63_06400	COG1040	competence protein
E3S63_06405	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
E3S63_06415	COG1739	Uncharacterized protein family UPF0029
E3S63_06420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3S63_06480	COG4607	ABC-type enterochelin transport system periplasmic component
E3S63_06485	COG4604	ABC transporter, ATP-binding protein
E3S63_06490	COG4605	iron ion homeostasis
E3S63_06495	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S63_06505	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3S63_06510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3S63_06530	COG3104	oligopeptide transport
E3S63_06555	COG1174	glycine betaine transport
E3S63_06560	COG0517	IMP dehydrogenase activity
E3S63_06560	COG1125	glycine betaine transport
E3S63_06565	COG0514	ATP-dependent DNA helicase (RecQ)
E3S63_06570	COG0488	(ABC) transporter
E3S63_06600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3S63_06605	COG0512	Glutamine amidotransferase of anthranilate synthase
E3S63_06605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3S63_06615	COG0720	synthase
E3S63_06650	COG0463	Glycosyl transferase, family 2
E3S63_06655	COG0656	L-ascorbic acid biosynthetic process
E3S63_06660	COG1253	flavin adenine dinucleotide binding
E3S63_06665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3S63_06670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3S63_06670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3S63_06670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3S63_06675	COG1105	Belongs to the carbohydrate kinase PfkB family
E3S63_06680	COG1349	DNA-binding transcription factor activity
E3S63_06685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3S63_06720	COG0471	metal ion transport
E3S63_06730	COG4989	oxidoreductase activity
E3S63_06735	COG0523	cobalamin synthesis protein
E3S63_06745	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E3S63_06750	COG4988	ABC transporter
E3S63_06770	COG1611	Belongs to the LOG family
E3S63_06800	COG2839	Protein conserved in bacteria
E3S63_06805	COG2814	Major facilitator Superfamily
E3S63_06810	COG0583	DNA-binding transcription factor activity
E3S63_06840	COG1917	Cupin 2, conserved barrel domain protein
E3S63_06840	COG4977	sequence-specific DNA binding
E3S63_06850	COG3942	CHAP domain
E3S63_06850	COG1388	LysM domain
E3S63_06855	COG0306	phosphate transporter
E3S63_06860	COG1392	Phosphate transport regulator
E3S63_06865	COG0577	efflux transmembrane transporter activity
E3S63_06870	COG1136	(ABC) transporter
E3S63_06885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3S63_06905	COG3949	Membrane
E3S63_06915	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E3S63_06925	COG2376	Dihydroxyacetone kinase
E3S63_06930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S63_06935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S63_06940	COG1120	ATPase activity
E3S63_06945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E3S63_06955	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3S63_06960	COG1132	(ABC) transporter
E3S63_06965	COG1686	Belongs to the peptidase S11 family
E3S63_06970	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E3S63_06980	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3S63_06985	COG1682	transport, permease protein
E3S63_06995	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
E3S63_07005	COG1321	iron dependent repressor
E3S63_07010	COG1121	(ABC) transporter
E3S63_07015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3S63_07020	COG0803	Belongs to the bacterial solute-binding protein 9 family
E3S63_07070	COG4974	Belongs to the 'phage' integrase family
E3S63_07120	COG4139	cobalamin transport
E3S63_07125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3S63_07160	COG1078	dGTPase activity
E3S63_07170	COG0655	NAD(P)H dehydrogenase (quinone) activity
E3S63_07175	COG0667	Aldo Keto reductase
E3S63_07210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3S63_07230	COG0083	homoserine kinase activity
E3S63_07235	COG0095	Lipoate-protein ligase
E3S63_07325	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
E3S63_07340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E3S63_07380	COG0561	phosphatase activity
E3S63_07390	COG1428	Deoxynucleoside kinase
E3S63_07395	COG1428	Deoxynucleoside kinase
E3S63_07400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E3S63_07430	COG1473	amidohydrolase
E3S63_07470	COG2813	Specifically methylates the guanine in position
E3S63_07530	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
E3S63_07550	COG4956	integral membrane protein (PIN domain superfamily)
E3S63_07555	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E3S63_07570	COG3880	PFAM UvrB UvrC protein
E3S63_07580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3S63_07595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3S63_07675	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3S63_07700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3S63_07715	COG1098	S1 RNA binding domain
E3S63_07725	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E3S63_07730	COG3956	TIGRFAM MazG family protein
E3S63_07735	COG2244	polysaccharide biosynthetic process
E3S63_07775	COG0251	oxidation-reduction process
E3S63_07780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E3S63_07790	COG4466	Protein conserved in bacteria
E3S63_07800	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E3S63_07805	COG0084	hydrolase, TatD family'
E3S63_07815	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E3S63_07825	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E3S63_07835	COG1774	PSP1 C-terminal conserved region
E3S63_07840	COG0470	DNA polymerase III
E3S63_07845	COG3870	Protein conserved in bacteria
E3S63_07855	COG1982	Orn Lys Arg decarboxylase major
E3S63_07890	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E3S63_07910	COG2188	Transcriptional regulator
E3S63_07915	COG0366	Alpha amylase catalytic
E3S63_07920	COG1263	PTS System
E3S63_07920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S63_07930	COG0493	'glutamate synthase
E3S63_07935	COG0067	glutamate synthase
E3S63_07935	COG0069	glutamate synthase activity
E3S63_07935	COG0070	glutamate synthase
E3S63_07940	COG0583	DNA-binding transcription factor activity
E3S63_07975	COG1464	Belongs to the NlpA lipoprotein family
E3S63_07980	COG2011	ABC-type metal ion transport system permease component
E3S63_07990	COG0626	cystathionine gamma-synthase activity
E3S63_07995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3S63_08000	COG0733	neurotransmitter:sodium symporter activity
E3S63_08005	COG1647	Serine aminopeptidase, S33
E3S63_08020	COG5609	conserved protein (DUF2294)
E3S63_08030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3S63_08055	COG0523	cobalamin synthesis protein
E3S63_08215	COG3759	membrane
E3S63_08250	COG2233	PERMEase
E3S63_08280	COG1823	symporter activity
E3S63_08380	COG0012	GTP binding
E3S63_08385	COG4481	Protein conserved in bacteria
E3S63_08390	COG0668	transmembrane transport
E3S63_08395	COG1475	DNA binding
E3S63_08400	COG0626	cystathionine gamma-synthase activity
E3S63_08405	COG0626	cystathionine gamma-synthase activity
E3S63_08410	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E3S63_08410	COG0646	methionine synthase
E3S63_08440	COG1131	(ABC) transporter
E3S63_08450	COG1476	TRANSCRIPTIONal
E3S63_08460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3S63_08465	COG0805	protein transport
E3S63_08470	COG0672	)-iron permease
E3S63_08480	COG2822	iron ion transport
E3S63_08485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3S63_08495	COG0431	NADPH-dependent FMN reductase
E3S63_08500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3S63_08505	COG0346	lactoylglutathione lyase activity
E3S63_08510	COG2271	Major facilitator Superfamily
E3S63_08530	COG3711	transcriptional antiterminator
E3S63_08535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3S63_08545	COG3037	sugar-specific permease SgaT UlaA
E3S63_08575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3S63_08625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3S63_08630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3S63_08660	COG0577	efflux transmembrane transporter activity
E3S63_08665	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
E3S63_08670	COG1114	Component of the transport system for branched-chain amino acids
E3S63_08790	COG1388	LysM domain
E3S63_08790	COG3942	CHAP domain
E3S63_08810	COG1131	(ABC) transporter
E3S63_08865	COG2226	methyltransferase
E3S63_08870	COG2723	6-phospho-beta-galactosidase activity
E3S63_08875	COG1263	PTS System
E3S63_08875	COG2190	(PTS) system
E3S63_08875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S63_08880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3S63_08915	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3S63_08920	COG1063	alcohol dehydrogenase
E3S63_08930	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3S63_08935	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3S63_08940	COG1063	alcohol dehydrogenase
E3S63_08950	COG1063	alcohol dehydrogenase
E3S63_08960	COG1063	alcohol dehydrogenase
E3S63_08965	COG3775	system Galactitol-specific IIC component
E3S63_08970	COG3414	Phosphotransferase system galactitol-specific IIB component
E3S63_08990	COG1957	nucleoside hydrolase
E3S63_08995	COG1263	PTS System
E3S63_08995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S63_08995	COG2190	(PTS) system
E3S63_09020	COG3189	MarR family transcriptional regulator
E3S63_09025	COG0747	negative chemotaxis
E3S63_09040	COG0318	PFAM AMP-dependent synthetase and ligase
E3S63_09045	COG1960	acyl-CoA dehydrogenase activity
E3S63_09055	COG0183	Belongs to the thiolase family
E3S63_09110	COG1755	Isoprenylcysteine carboxyl methyltransferase
E3S63_09120	COG0673	inositol 2-dehydrogenase activity
E3S63_09125	COG0673	inositol 2-dehydrogenase activity
E3S63_09130	COG3833	ABC-type maltose transport systems, permease component
E3S63_09135	COG1175	transmembrane transport
E3S63_09145	COG3842	ATPase activity
E3S63_09165	COG0405	Gamma-glutamyltransferase
E3S63_09175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3S63_09195	COG1131	(ABC) transporter
E3S63_09220	COG1136	(ABC) transporter
E3S63_09245	COG1737	Transcriptional regulator
E3S63_09275	COG3961	Belongs to the TPP enzyme family
E3S63_09280	COG1335	isochorismatase
E3S63_09285	COG1114	Component of the transport system for branched-chain amino acids
E3S63_09335	COG5609	conserved protein (DUF2294)
E3S63_09340	COG1960	acyl-CoA dehydrogenase activity
E3S63_09345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3S63_09380	COG2832	Protein of unknown function (DUF454)
E3S63_09390	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3S63_09395	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E3S63_09405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3S63_09435	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3S63_09445	COG1086	Polysaccharide biosynthesis protein
E3S63_09470	COG1012	belongs to the aldehyde dehydrogenase family
E3S63_09470	COG1454	alcohol dehydrogenase
E3S63_09485	COG0737	Belongs to the 5'-nucleotidase family
E3S63_09505	COG3639	organic phosphonate transmembrane transporter activity
E3S63_09525	COG2814	Major facilitator Superfamily
E3S63_09530	COG0813	purine-nucleoside phosphorylase activity
E3S63_09560	COG0438	transferase activity, transferring glycosyl groups
E3S63_09565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3S63_09570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3S63_09590	COG1475	DNA binding
E3S63_09595	COG0019	diaminopimelate decarboxylase activity
E3S63_09605	COG4264	IucA IucC family
E3S63_09610	COG4264	IucA IucC family
E3S63_09615	COG2814	Major facilitator Superfamily
E3S63_09620	COG4264	IucA IucC family
E3S63_09625	COG2423	ornithine cyclodeaminase activity
E3S63_09635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3S63_09640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S63_09645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S63_09660	COG1620	l-lactate permease
E3S63_09675	COG0697	spore germination
E3S63_09680	COG4716	Myosin-crossreactive antigen
E3S63_09685	COG1283	sodium-dependent phosphate transmembrane transporter activity
E3S63_09695	COG1473	amidohydrolase
E3S63_09730	COG0823	Involved in the tonB-independent uptake of proteins
E3S63_09775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3S63_09780	COG2210	Belongs to the sulfur carrier protein TusA family
E3S63_09785	COG1937	Protein conserved in bacteria
E3S63_09790	COG0730	response to heat
E3S63_09860	COG2205	protein histidine kinase activity
E3S63_09865	COG0745	RESPONSE REGULATOR receiver
E3S63_09920	COG2003	Belongs to the UPF0758 family
E3S63_09955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3S63_09965	COG0730	response to heat
E3S63_09970	COG1937	Protein conserved in bacteria
E3S63_09975	COG2210	Belongs to the sulfur carrier protein TusA family
E3S63_09980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3S63_09990	COG1940	carbohydrate kinase activity
E3S63_09990	COG1846	Transcriptional regulator
E3S63_10015	COG2030	dehydratase
E3S63_10020	COG0584	glycerophosphoryl diester phosphodiesterase
E3S63_10075	COG0737	Belongs to the 5'-nucleotidase family
E3S63_10080	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E3S63_10090	COG4863	YycH protein
E3S63_10120	COG0305	Participates in initiation and elongation during chromosome replication
E3S63_10130	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
E3S63_10140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3S63_10165	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E3S63_10185	COG2501	S4 domain
E3S63_10225	COG1475	DNA binding
E3S63_10245	COG1278	Cold shock
E3S63_10255	COG0577	efflux transmembrane transporter activity
E3S63_10260	COG1136	(ABC) transporter
E3S63_10275	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
E3S63_10285	COG2962	Rard protein
E3S63_10290	COG0471	metal ion transport
E3S63_10375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E3S63_10465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3S63_10485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3S63_10505	COG1073	alpha beta
E3S63_10520	COG0438	transferase activity, transferring glycosyl groups
E3S63_10535	COG3433	isochorismatase activity
E3S63_10535	COG1535	isochorismatase
E3S63_10540	COG1705	Flagellar rod assembly protein muramidase FlgJ
E3S63_10540	COG3942	CHAP domain
E3S63_10550	COG1482	cell wall glycoprotein biosynthetic process
E3S63_10555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3S63_10555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3S63_10555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3S63_10560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3S63_10560	COG3711	transcriptional antiterminator
E3S63_10580	COG1438	arginine binding
E3S63_10625	COG1846	Transcriptional regulator
E3S63_10635	COG1785	Belongs to the alkaline phosphatase family
E3S63_10645	COG0745	RESPONSE REGULATOR receiver
E3S63_10650	COG2205	protein histidine kinase activity
E3S63_10655	COG1136	(ABC) transporter
E3S63_10675	COG0386	Belongs to the glutathione peroxidase family
E3S63_10685	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E3S63_10700	COG2851	Citrate transporter
E3S63_10725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3S63_10730	COG1510	regulation of RNA biosynthetic process
E3S63_10740	COG1012	belongs to the aldehyde dehydrogenase family
E3S63_10760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3S63_10790	COG0531	amino acid
E3S63_10800	COG3527	Alpha-acetolactate decarboxylase
E3S63_10805	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E3S63_10865	COG0167	dihydroorotate dehydrogenase activity
E3S63_10870	COG3001	Fructosamine kinase
E3S63_10975	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E3S63_10975	COG2755	lipolytic protein G-D-S-L family
E3S63_10980	COG3942	CHAP domain
E3S63_11010	COG0436	Aminotransferase
E3S63_11055	COG2409	Drug exporters of the RND superfamily
E3S63_11080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3S63_11085	COG3425	synthase
E3S63_11095	COG3942	CHAP domain
E3S63_11105	COG0583	DNA-binding transcription factor activity
E3S63_11120	COG0028	Belongs to the TPP enzyme family
E3S63_11140	COG0657	acetylesterase activity
E3S63_11145	COG0697	spore germination
E3S63_11160	COG1760	l-serine dehydratase
E3S63_11165	COG1760	l-serine dehydratase
E3S63_11185	COG3764	Sortase (surface protein transpeptidase)
E3S63_11195	COG1131	(ABC) transporter
E3S63_11200	COG0561	phosphatase activity
E3S63_11215	COG2514	catechol 2,3-dioxygenase activity
E3S63_11225	COG1846	Transcriptional regulator
E3S63_11230	COG0346	lactoylglutathione lyase activity
E3S63_11235	COG0400	carboxylic ester hydrolase activity
E3S63_11255	COG1131	(ABC) transporter
E3S63_11265	COG0586	Pfam SNARE associated Golgi protein
E3S63_11270	COG2271	Major facilitator Superfamily
E3S63_11280	COG4876	unkown
E3S63_11285	COG2357	RelA SpoT domain protein
E3S63_11290	COG0789	Transcriptional regulator
E3S63_11295	COG1802	Transcriptional regulator
E3S63_11300	COG1070	Carbohydrate kinase
E3S63_11335	COG1846	Transcriptional regulator
E3S63_11375	COG0494	nUDIX hydrolase
E3S63_11465	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3S63_11470	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E3S63_11475	COG1028	Short-chain dehydrogenase reductase Sdr
E3S63_11480	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E3S63_11535	COG0069	glutamate synthase activity
E3S63_11540	COG4808	Protein conserved in bacteria
E3S63_11555	COG1363	Peptidase, m42
E3S63_11560	COG4619	ABC transporter
E3S63_11565	COG0390	transport system, permease component
E3S63_11570	COG2814	Major facilitator Superfamily
E3S63_11575	COG2272	Belongs to the type-B carboxylesterase lipase family
E3S63_11580	COG0531	amino acid
E3S63_11585	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
E3S63_11605	COG1174	glycine betaine transport
E3S63_11615	COG1174	glycine betaine transport
E3S63_11625	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E3S63_11640	COG0531	amino acid
E3S63_11650	COG1113	amino acid transport
E3S63_11670	COG2814	Major facilitator Superfamily
E3S63_11680	COG1929	Belongs to the glycerate kinase type-1 family
E3S63_11700	COG1132	(ABC) transporter
E3S63_11710	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E3S63_11715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E3S63_11725	COG0156	8-amino-7-oxononanoate synthase activity
E3S63_11765	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E3S63_11780	COG2814	Major facilitator Superfamily
E3S63_11785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3S63_11790	COG0765	amino acid transport
E3S63_11795	COG1126	abc transporter atp-binding protein
E3S63_11835	COG0803	Belongs to the bacterial solute-binding protein 9 family
E3S63_11835	COG3443	Belongs to the bacterial solute-binding protein 9 family
E3S63_11850	COG2116	formate transmembrane transporter activity
E3S63_11855	COG0454	-acetyltransferase
E3S63_11865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3S63_11870	COG2146	nitrite reductase [NAD(P)H] activity
E3S63_11880	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E3S63_11885	COG1140	nitrate reductase beta subunit
E3S63_11895	COG2181	nitrate reductase activity
E3S63_11915	COG0789	Transcriptional regulator
E3S63_11955	COG3871	stress protein (general stress protein 26)
E3S63_11970	COG1263	PTS System
E3S63_11970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S63_11985	COG1511	domain protein
E3S63_12010	COG0604	alcohol dehydrogenase
E3S63_12030	COG1620	l-lactate permease
E3S63_12090	COG2814	Major facilitator Superfamily
E3S63_12100	COG1566	PFAM secretion protein HlyD family protein
E3S63_12105	COG2814	Major facilitator Superfamily
E3S63_12115	COG0657	acetylesterase activity
E3S63_12130	COG0598	Magnesium transport protein CorA
E3S63_12140	COG0786	glutamate:sodium symporter activity
E3S63_12150	COG3152	Membrane
E3S63_12155	COG4152	abc transporter atp-binding protein
E3S63_12160	COG1668	transmembrane transport
E3S63_12180	COG2258	MOSC domain
E3S63_12205	COG0583	DNA-binding transcription factor activity
E3S63_12220	COG1473	amidohydrolase
E3S63_12225	COG1028	Short-chain dehydrogenase reductase Sdr
E3S63_12245	COG1737	Transcriptional regulator
E3S63_12250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S63_12250	COG1263	PTS System
E3S63_12260	COG0385	Bile acid
E3S63_12265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3S63_12285	COG1113	amino acid transport
E3S63_12350	COG3942	CHAP domain
E3S63_12365	COG1757	Na H antiporter
E3S63_12375	COG3942	CHAP domain
E3S63_12435	COG4413	Urea transporter
E3S63_12440	COG1960	acyl-CoA dehydrogenase activity
E3S63_12455	COG1268	BioY protein
E3S63_12470	COG0725	ABC transporter, periplasmic molybdate-binding protein
E3S63_12475	COG4149	molybdate abc transporter
E3S63_12480	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E3S63_12485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3S63_12505	COG1763	Mo-molybdopterin cofactor biosynthetic process
E3S63_12565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3S63_12610	COG2252	PERMEase
E3S63_12725	COG0201	protein transport
E3S63_12830	COG0028	Belongs to the TPP enzyme family
E3S63_12835	COG3527	Alpha-acetolactate decarboxylase
E3S63_12855	COG5492	domain, Protein
E3S63_12865	COG0789	Transcriptional regulator
E3S63_12870	COG0656	L-ascorbic acid biosynthetic process
E3S63_12935	COG2130	NADP-dependent
E3S63_12945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3S63_12970	COG2814	Major facilitator Superfamily
E3S63_12975	COG4264	IucA IucC family
E3S63_12980	COG3457	Alanine racemase
E3S63_12990	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E3S63_12995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S63_13000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S63_13015	COG1988	membrane-bound metal-dependent
E3S63_13025	COG1272	protein, Hemolysin III
E3S63_13040	COG2814	Major facilitator Superfamily
E3S63_13045	COG0489	protein tyrosine kinase activity
E3S63_13110	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E3S63_13140	COG3711	transcriptional antiterminator
E3S63_13155	COG1119	ATPase activity
E3S63_13160	COG0561	phosphatase activity
E3S63_13185	COG0640	Transcriptional regulator
E3S63_13190	COG0702	epimerase
E3S63_13195	COG1482	cell wall glycoprotein biosynthetic process
E3S63_13215	COG0783	Belongs to the Dps family
E3S63_13265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3S63_13305	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E3S63_13325	COG2890	protein-(glutamine-N5) methyltransferase activity
E3S63_13330	COG0009	L-threonylcarbamoyladenylate synthase
E3S63_13355	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3S63_13430	COG0629	single-stranded DNA binding
E3S63_13480	COG1418	mRNA catabolic process
E3S63_13490	COG1937	Protein conserved in bacteria
E3S63_13505	COG0772	Belongs to the SEDS family
E3S63_13515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3S63_13530	COG0745	RESPONSE REGULATOR receiver
E3S63_13535	COG2205	protein histidine kinase activity
E3S63_13565	COG3428	Bacterial PH domain
E3S63_13595	COG2208	phosphoserine phosphatase activity
E3S63_13600	COG1366	Belongs to the anti-sigma-factor antagonist family
E3S63_13610	COG1191	sigma factor activity
E3S63_13615	COG2183	response to ionizing radiation
E3S63_13685	COG0028	Belongs to the TPP enzyme family
E3S63_13700	COG0802	atpase or kinase
E3S63_13705	COG1214	PFAM Peptidase M22, glycoprotease
E3S63_13710	COG0456	acetyltransferase
E3S63_13720	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E3S63_13730	COG0488	(ABC) transporter
E3S63_13740	COG2391	methyltransferase activity
E3S63_13745	COG0425	Belongs to the sulfur carrier protein TusA family
E3S63_13750	COG0004	ammonium transporteR
E3S63_13755	COG1609	Transcriptional regulator
E3S63_13760	COG1621	beta-fructofuranosidase activity
E3S63_13765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3S63_13830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3S63_13885	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3S63_14100	COG3682	Transcriptional regulator
E3S63_14120	COG0604	alcohol dehydrogenase