locus-tag class description EWF18_00025 ENOG4105DWT malate dehydrogenase (quinone) EWF18_00100 ENOG4105ECB domain protein EWF18_00130 ENOG410606W general stress protein EWF18_00175 ENOG4107TXC Transcriptional regulator EWF18_00205 ENOG4108IUE nitrate reductase beta subunit EWF18_00215 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EWF18_00220 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit EWF18_00225 ENOG4108IFG nitrite reductase, (NAD(P)H) EWF18_00235 ENOG4108XSB acetyltransferase, (GNAT) family EWF18_00240 ENOG4105TMB Formate nitrite transporter EWF18_00255 ENOG4105DSE periplasmic solute binding protein EWF18_00290 ENOG4105CDA abc transporter atp-binding protein EWF18_00295 ENOG4105DRP amino acid AbC transporter EWF18_00300 ENOG4105EAB amino acid AbC transporter EWF18_00355 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) EWF18_00380 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EWF18_00385 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EWF18_00395 ENOG4105BZ1 (ABC) transporter EWF18_00420 ENOG4105BZW Glycerate kinase EWF18_00430 ENOG4105C2C drug resistance transporter, Bcr CflA EWF18_00450 ENOG4105C85 amino acid EWF18_00455 ENOG4105EEQ Na H antiporter EWF18_00465 ENOG4105C0X amino acid EWF18_00485 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EWF18_00490 ENOG4105C57 major facilitator superfamily EWF18_00495 ENOG4105R40 Glycine betaine carnitine choline EWF18_00505 ENOG4105E90 ABC transporter EWF18_00525 ENOG4105CZ9 Domain of unknown function (DU1801) EWF18_00535 ENOG4107QTZ amino acid EWF18_00540 ENOG4105EBR Carboxylesterase EWF18_00545 ENOG4105F27 Major Facilitator EWF18_00550 ENOG4105C4B ABC transporter, permease EWF18_00555 ENOG41083J0 (ABC) transporter EWF18_00580 ENOG4105PQ4 (LipO)protein EWF18_00585 ENOG4105CBC glutamate synthase EWF18_00615 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EWF18_00650 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EWF18_00655 ENOG4105CFC Transporter EWF18_00660 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EWF18_00745 ENOG4105M6F mutator MutT protein EWF18_00825 ENOG4105CMG Carbohydrate kinase EWF18_00830 ENOG4105G3Z GntR family transcriptional regulator EWF18_00845 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) EWF18_00855 ENOG4105DJB Major Facilitator Superfamily EWF18_00860 ENOG4107T5V SNARE associated Golgi EWF18_00880 ENOG4105CJ1 ABC, transporter EWF18_00900 ENOG4105FBA Phospholipase Carboxylesterase EWF18_00910 ENOG41090MY MarR family Transcriptional regulator EWF18_00920 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase EWF18_00930 ENOG4105C5I Dehydrogenase EWF18_00935 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) EWF18_00940 ENOG4108Z15 abc transporter atp-binding protein EWF18_00945 ENOG4106KKU EWF18_00950 ENOG4108Z6X (sortase) family EWF18_00955 ENOG4108Z7F N-acetyltransferase EWF18_00970 ENOG4105EJQ L-serine dehydratase EWF18_00990 ENOG4108UZ3 Transporter EWF18_01020 ENOG41067MG lrgb family EWF18_01030 ENOG4105CMU LysR family (Transcriptional regulator EWF18_01040 ENOG41068JE domain protein EWF18_01050 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase EWF18_01055 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EWF18_01080 ENOG4105EYF MMPL domain protein EWF18_01155 ENOG41068JE domain protein EWF18_01160 ENOG4105EXC Acyl-transferase EWF18_01215 ENOG4105CHR reductase EWF18_01225 ENOG4108SXP alpha beta EWF18_01240 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase EWF18_01265 ENOG4105FGM Fructosamine kinase EWF18_01270 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) EWF18_01325 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EWF18_01330 ENOG4107FQX Alpha-acetolactate decarboxylase EWF18_01345 ENOG4105CUB amino acid EWF18_01350 ENOG4108JPW Aminotransferase EWF18_01365 ENOG4105DWT malate dehydrogenase (quinone) EWF18_01375 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EWF18_01395 ENOG4105C26 Dehydrogenase EWF18_01415 ENOG4105C94 Transporter EWF18_01430 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) EWF18_01435 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase EWF18_01440 ENOG4105D4T Citrate transporter EWF18_01445 ENOG4108Z73 Siroheme synthase EWF18_01450 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EWF18_01505 ENOG4105G6Z alkaline phosphatase EWF18_01520 ENOG4108U05 Transcriptional regulator EWF18_01530 ENOG4105T6C Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps EWF18_01540 ENOG4105C5B carbamate kinase EWF18_01550 ENOG4105DBV ornithine carbamoyltransferase EWF18_01555 ENOG4105CEU Arginine dihydrolase EWF18_01590 ENOG4105DM4 PTS System EWF18_01595 ENOG4105DG6 mannose-6-phosphate isomerase EWF18_01605 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase EWF18_01610 ENOG4105WQI isochorismatase EWF18_01635 ENOG4106E62 Accessory Sec system protein Asp3 EWF18_01640 ENOG41089G2 accessory Sec system protein Asp2 EWF18_01645 ENOG4108XJK accessory Sec system protein Asp1 EWF18_01650 ENOG4106YAG Part of the accessory SecA2 SecY2 system specifically required for export of EWF18_01660 ENOG4105EW6 flavin reductase domain protein, FMN-binding EWF18_01685 ENOG4107XC4 flavin reductase domain protein, FMN-binding EWF18_01690 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EWF18_01710 ENOG4105HTX biosynthesis protein EWF18_01715 ENOG4108IG5 Transcriptional regulator EWF18_01720 ENOG4107QJZ Glycosyl transferase, family 2 EWF18_01730 ENOG4107UVV polysaccharide deacetylase EWF18_01755 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EWF18_01770 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EWF18_01780 ENOG4105CIH Imidazole acetol-phosphate transaminase EWF18_01815 ENOG4108JJB ABC transporter EWF18_01860 ENOG4107QPK )-transporter EWF18_01865 ENOG4105FR1 rard protein EWF18_01875 ENOG4105D9G High-affinity EWF18_01890 ENOG4105C19 ABC transporter EWF18_01950 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) EWF18_01985 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EWF18_01990 ENOG410848D S4 domain protein YaaA EWF18_02005 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EWF18_02010 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) EWF18_02040 ENOG4105DWV Homoserine O-trans-acetylase EWF18_02050 ENOG4105BZR domain protein EWF18_02070 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EWF18_02105 ENOG4105Q2H domain protein EWF18_02110 ENOG4105CGH 5'-nucleotidase EWF18_02140 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EWF18_02150 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase EWF18_02225 ENOG4105DZR Type I site-specific deoxyribonuclease EWF18_02255 ENOG4105KEG ribosomal-protein-alanine acetyltransferase EWF18_02280 ENOG4107QMH DNA methylase EWF18_02285 ENOG4107J0C type IIi EWF18_02345 ENOG41087NI Sulfite exporter TauE/SafE EWF18_02350 ENOG4105XTG Pfam:DUF156 EWF18_02355 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase EWF18_02360 ENOG4105C5X domain protein EWF18_02410 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C EWF18_02460 ENOG4105C57 major facilitator superfamily EWF18_02475 ENOG4105CCI Myosin-Cross-Reactive Antigen EWF18_02505 ENOG4108IHU transport system permease protein EWF18_02510 ENOG4105DQ5 transport system permease protein EWF18_02515 ENOG4108MES Periplasmic binding protein EWF18_02525 ENOG4105CIF Ornithine Cyclodeaminase EWF18_02530 ENOG4105DJU Siderophore biosynthesis protein EWF18_02535 ENOG4105C6X Major Facilitator EWF18_02540 ENOG4105DBM Siderophore biosynthesis protein EWF18_02545 ENOG4105DUU IucA IucC family protein EWF18_02555 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EWF18_02560 ENOG41067FT ParB-like nuclease domain EWF18_02580 ENOG4105CHR reductase EWF18_02590 ENOG4108IAJ Nad-dependent epimerase dehydratase EWF18_02600 ENOG4105CPK Glycosyl transferase (Group 1 EWF18_02635 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EWF18_02640 ENOG4108J8C transporter major facilitator family protein EWF18_02645 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EWF18_02680 ENOG4105CGH 5'-nucleotidase EWF18_02695 ENOG4108EKI Dehydrogenase EWF18_02720 ENOG4105C5E polysaccharide biosynthesis protein EWF18_02730 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EWF18_02760 ENOG4105D3Q Sugar transferase EWF18_02775 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EWF18_02785 ENOG4105WD1 Membrane EWF18_02790 ENOG4105C26 Dehydrogenase EWF18_02795 ENOG4105PGM cation diffusion facilitator family transporter EWF18_02830 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) EWF18_02865 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) EWF18_02875 ENOG4105C8Y Acetylornithine aminotransferase EWF18_02880 ENOG4105CWM branched-chain amino acid transport system II carrier protein EWF18_02885 ENOG4105D3W isochorismatase EWF18_02890 ENOG4107RA9 decarboxylase EWF18_02920 ENOG4105QEK Transcriptional regulator EWF18_02960 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EWF18_02970 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EWF18_03005 ENOG4105EG2 ABC transporter, permease EWF18_03020 ENOG4105CK5 oxidoreductase EWF18_03030 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase EWF18_03035 ENOG4105CXY transporter EWF18_03040 ENOG4107VQW regulatoR EWF18_03090 ENOG4105CHU acetyl-coa acetyltransferase EWF18_03095 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EWF18_03100 ENOG4105C1G acyl-Coa dehydrogenase EWF18_03105 ENOG4105CEY Amp-dependent synthetase and ligase EWF18_03110 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) EWF18_03120 ENOG4107RRN ABC transporter substrate-binding protein EWF18_03125 ENOG4105K78 MarR family Transcriptional regulator EWF18_03160 ENOG4105CI1 PTS System EWF18_03165 ENOG4105DU0 nucleoside hydrolase EWF18_03185 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) EWF18_03190 ENOG4105DT3 PTS system, galactitol-specific IIc component EWF18_03195 ENOG4105CPQ Dehydrogenase EWF18_03205 ENOG4105CPQ Dehydrogenase EWF18_03210 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) EWF18_03215 ENOG4105EJJ Dehydrogenase EWF18_03220 ENOG4107RZX Teichoic acid biosynthesis protein EWF18_03225 ENOG4107SJB teichoic acid biosynthesis EWF18_03235 ENOG4105EJJ Dehydrogenase EWF18_03240 ENOG4107RZX Teichoic acid biosynthesis protein EWF18_03290 ENOG4105CI1 PTS System EWF18_03295 ENOG4105CS2 ec 3.2.1.21 EWF18_03300 ENOG4105DVA methyltransferase EWF18_03320 ENOG4105EV1 Ribose uptake protein RbsU EWF18_03350 ENOG41061JJ Peptidase family M23 EWF18_03355 ENOG4105CJ1 ABC, transporter EWF18_03375 ENOG4105VRS hydrolase family 18 EWF18_03395 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) EWF18_03500 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family EWF18_03510 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) EWF18_03540 ENOG4105D9N nucleoside EWF18_03545 ENOG4107RJ1 sodium solute EWF18_03555 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) EWF18_03560 ENOG4106KNT transcriptional regulator EWF18_03570 ENOG4105DWD nucleoside recognition domain protein EWF18_03575 ENOG4105J1V Triacylglycerol lipase EWF18_03595 ENOG4105DEN Luciferase family EWF18_03620 ENOG4105CMR udp-glucose 4-epimerase EWF18_03625 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC EWF18_03635 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia EWF18_03640 ENOG4105CID antiterminator EWF18_03655 ENOG4105C3S Mate efflux family protein EWF18_03665 ENOG4105CXY transporter EWF18_03680 ENOG4107V0Z fmn reductase EWF18_03685 ENOG4105HMI Membrane EWF18_03700 ENOG410650H (LipO)protein EWF18_03705 ENOG4105DBE peroxidase EWF18_03710 ENOG4107SJW iron permease, FTR1 EWF18_03715 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EWF18_03720 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EWF18_03730 ENOG4105VZ8 Transcriptional regulator EWF18_03740 ENOG4105DA5 (ABC) transporter EWF18_03775 ENOG4105C28 cystathionine EWF18_03780 ENOG4105C28 cystathionine EWF18_03790 ENOG4105FA0 parb-like partition protein EWF18_03795 ENOG4105D8X mechanosensitive ion channel EWF18_03800 ENOG4105VDK protein, conserved in bacteria EWF18_03805 ENOG4105C3G gtp-binding protein EWF18_03825 ENOG4108UUM single-stranded DNA-binding protein EWF18_03840 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EWF18_03900 ENOG4108JU3 Alkyl hydroperoxide reductase EWF18_03915 ENOG4107R6U sodium dicarboxylate symporter EWF18_03950 ENOG4105C2W permease EWF18_04010 ENOG41075D4 Aminoglycoside 6-adenylyltransferase EWF18_04040 ENOG4105KA3 membrAne EWF18_04230 ENOG4105CKI cobalamin synthesis protein EWF18_04255 ENOG4108TWJ NADH dehydrogenase subunit 5 EWF18_04260 ENOG4105EVH UPF0753 protein EWF18_04265 ENOG4105GPN Uncharacterized conserved protein (DUF2294) EWF18_04300 ENOG4105C28 cystathionine EWF18_04305 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EWF18_04310 ENOG4108UMI ABC transporter, permease EWF18_04315 ENOG4105D01 (LipO)protein EWF18_04350 ENOG4105C5Q Transcriptional regulator EWF18_04360 ENOG4105BZ8 glutamate synthase EWF18_04375 ENOG4105C5Y PTS System EWF18_04380 ENOG4105CG3 alpha amylase, catalytic region EWF18_04385 ENOG4107414 GntR family transcriptional regulator EWF18_04405 ENOG4105C6E dna polymerase iii EWF18_04410 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) EWF18_04445 ENOG4105CXN decarboxylase EWF18_04455 ENOG4105X0R protein from nitrogen regulatory protein P-II EWF18_04460 ENOG4105FA2 dna polymerase iii EWF18_04465 ENOG4105MA4 psp1 domain protein EWF18_04475 ENOG41060K3 Methyltransferase EWF18_04485 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EWF18_04490 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EWF18_04495 ENOG4105F8V Hydrolase, tatD family EWF18_04500 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) EWF18_04510 ENOG4105W42 Veg protein EWF18_04520 ENOG4105DFT pur operon repressor EWF18_04525 ENOG4105KME endoribonuclease L-psp EWF18_04545 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EWF18_04575 ENOG4108IY2 MazG family EWF18_04580 ENOG41082I2 s4 domain protein EWF18_04590 ENOG41060GV RNA binding s1 domain protein EWF18_04600 ENOG4108UGV hypoxanthine phosphoribosyltransferase EWF18_04605 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EWF18_04615 ENOG4105C6T cysteine synthase EWF18_04625 ENOG4105KRF dihydroneopterin aldolase EWF18_04630 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EWF18_04725 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EWF18_04740 ENOG4105D9N nucleoside EWF18_04750 ENOG4108Z0C Uvrb UvrC protein EWF18_04765 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EWF18_04770 ENOG4105CTP PilT protein domain protein EWF18_04795 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) EWF18_04800 ENOG4105C2N RNA methyltransferase TrmH family group 3 EWF18_04820 ENOG410683Z Preprotein translocase SecE subunit EWF18_04825 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EWF18_04855 ENOG4107Y49 methyltransferase EWF18_04860 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EWF18_04865 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EWF18_04900 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EWF18_04920 ENOG4105CM2 brancheD-chain amino acid aminotransferase EWF18_04925 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase EWF18_04930 ENOG4105ZMH deoxynucleoside kinase EWF18_04940 ENOG4108Z6B deaminase EWF18_04945 ENOG410667J hydrolase EWF18_05005 ENOG4108VA3 3-hexulose-6-phosphate synthase EWF18_05055 ENOG4105DWF phosphomethylpyrimidine kinase EWF18_05100 ENOG4108IJ2 phosphate acetyltransferase EWF18_05105 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) EWF18_05110 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) EWF18_05130 ENOG4107QN2 dihydrolipoyl dehydrogenase EWF18_05195 ENOG4105CPC Aldo Keto reductase EWF18_05200 ENOG4108WS4 fmn reductase EWF18_05210 ENOG4105DCI Phosphohydrolase EWF18_05215 ENOG4108XFG YwhD family EWF18_05250 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EWF18_05255 ENOG4108IU2 vtamin B12-transporter permease EWF18_05265 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EWF18_05280 ENOG4108MEZ Alpha beta hydrolase EWF18_05305 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off EWF18_05345 ENOG4105EEQ Na H antiporter EWF18_05355 ENOG4105CC5 ABC transporter EWF18_05360 ENOG4105DIK (ABC) transporter EWF18_05365 ENOG4107R5H iron (metal) dependent repressor, dtxr family EWF18_05375 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family EWF18_05400 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase EWF18_05410 ENOG4105BZ1 (ABC) transporter EWF18_05425 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) EWF18_05430 ENOG4105E0A ABC, transporter EWF18_05435 ENOG4105DQ5 transport system permease protein EWF18_05440 ENOG4105EHG Permease protein EWF18_05445 ENOG4105CMT Dihydroxyacetone kinase EWF18_05455 ENOG4105VDH Dihydroxyacetone kinase EWF18_05465 ENOG4108K88 Membrane EWF18_05505 ENOG4105C19 ABC transporter EWF18_05515 ENOG4107GRR phosphate transport regulator EWF18_05520 ENOG4105CJ3 phosphate transporter EWF18_05525 ENOG4105VRS hydrolase family 18 EWF18_05535 ENOG4105ID8 Transcriptional regulator, ARAC family EWF18_05575 ENOG4105S8Q sugar efflux transporter EWF18_05580 ENOG4105SXS Protein of unknown function (DUF456) EWF18_05605 ENOG4108YYQ gCN5-related N-acetyltransferase EWF18_05610 ENOG4108URH decarboxylase EWF18_05630 ENOG4108JJ9 ABC, transporter EWF18_05640 ENOG41083AI transcriptional regulator), MarR family EWF18_05645 ENOG4105CKI cobalamin synthesis protein EWF18_05650 ENOG4107QM2 Aldo Keto reductase EWF18_05660 ENOG4107QPK )-transporter EWF18_05665 ENOG4105CVP deoxyribo-dipyrimidine photolyase EWF18_05695 ENOG4108Z66 YbaK ebsC protein EWF18_05700 ENOG4105E98 transcriptional regulator DeoR family EWF18_05705 ENOG4105DE4 1-phosphofructokinase EWF18_05710 ENOG4105DM4 PTS System EWF18_05715 ENOG4105CE4 GlcNAc 6-P deacetylase EWF18_05720 ENOG4105C37 (CBS) domain EWF18_05730 ENOG4105CKK Glycosyl transferase, family 2 EWF18_05760 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EWF18_05765 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase EWF18_05775 ENOG4105DDQ anthranilate synthase EWF18_05780 ENOG4105CRQ synthase (Component I) EWF18_05810 ENOG4105C5H ABC transporter EWF18_05815 ENOG4105C9U ATP-dependent DNA helicase RecQ EWF18_05820 ENOG4108IJ8 ABC transporter EWF18_05835 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C EWF18_05855 ENOG4105DUX Transporter EWF18_05885 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EWF18_05890 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EWF18_05900 ENOG4105DHS permease protein EWF18_05905 ENOG4105CM4 permease protein EWF18_05910 ENOG4108IPW abc transporter atp-binding protein EWF18_05970 ENOG4105ESV Glycosyl transferase, family 4 EWF18_05975 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EWF18_05990 ENOG41081UC Inherit from COG: Competence protein EWF18_06020 ENOG41068JE domain protein EWF18_06040 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EWF18_06065 ENOG4105C3M thioredoxin reductase EWF18_06080 ENOG4105CHW UPF0052 protein EWF18_06120 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EWF18_06135 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EWF18_06150 ENOG4105XZU Preprotein translocase, subunit SecG EWF18_06255 ENOG4108TFU terminase (Small subunit) EWF18_06350 ENOG4105VEQ Cold shock protein EWF18_06390 ENOG4105CVJ phosphoglycerate mutase EWF18_06395 ENOG4108ZUB Lysine exporter protein (Lyse ygga) EWF18_06420 ENOG4105SZ6 Thioredoxin EWF18_06425 ENOG41080E8 Transcriptional regulator, Spx MgsR family EWF18_06440 ENOG4108XI2 Domain of unknown function (DUF1963) EWF18_06465 ENOG4108UMI ABC transporter, permease EWF18_06470 ENOG4105D01 (LipO)protein EWF18_06485 ENOG4105C3K feS assembly ATPase SufC EWF18_06490 ENOG4105JRK feS assembly protein SufD EWF18_06495 ENOG4105C9B Cysteine desulfurase EWF18_06500 ENOG4108UNV SUF system FeS assembly protein, NifU family EWF18_06525 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EWF18_06575 ENOG4108UUM single-stranded DNA-binding protein EWF18_06595 ENOG4106CVF DNA replication protein EWF18_06690 ENOG4105IG6 Phage terminase, large subunit EWF18_06800 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis EWF18_06820 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase EWF18_06860 ENOG4105I3N Conserved Protein EWF18_06880 ENOG4105MMD transcriptional regulator EWF18_06920 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein EWF18_06930 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD EWF18_06935 ENOG41083MR nifu domain-containing protein EWF18_06955 ENOG4108YX9 iron--sulfur cluster insertion protein erpA EWF18_06965 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EWF18_06975 ENOG4105KA0 thioesterase Superfamily protein EWF18_07030 ENOG41060GV RNA binding s1 domain protein EWF18_07035 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EWF18_07040 ENOG4105C8Y Acetylornithine aminotransferase EWF18_07045 ENOG4105D82 Glutamate dehydrogenase EWF18_07050 ENOG4107VXM glycerophosphoryl diester phosphodiesterase EWF18_07080 ENOG4105C3F Signal peptidase i EWF18_07090 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation EWF18_07110 ENOG4108KP7 hydrolase EWF18_07120 ENOG4105EXC Acyl-transferase EWF18_07125 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EWF18_07150 ENOG4105KIS phospholipid-binding protein EWF18_07170 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EWF18_07180 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EWF18_07185 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EWF18_07195 ENOG4108JQ7 (ABC) transporter EWF18_07215 ENOG4108JQ7 (ABC) transporter EWF18_07225 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EWF18_07230 ENOG4105C31 Tryptophanyl-tRNA synthetase EWF18_07235 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) EWF18_07250 ENOG4105DPN Oligoendopeptidase f EWF18_07255 ENOG4105T58 Dithiol-disulfide isomerase EWF18_07260 ENOG4108Z18 K06886 hemoglobin EWF18_07285 ENOG4105EMS pseudouridine synthase EWF18_07290 ENOG4105CJW magnesium transporter EWF18_07305 ENOG4105C02 permease EWF18_07325 ENOG4108PK2 permease that is required for glycolipid anchoring of LTA. May facilitate the transport of diglucosyl- diacylglycerol (Glc2-DAG) from the inner to the outer leaflet of the cytoplasmic membrane, delivering Glc2-DAG as a substrate for LTA synthesis, thereby generating glycolipid-anchored LTA. Appears to play an important role in virulence EWF18_07350 ENOG4107TS3 membrane protein, TerC EWF18_07370 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic EWF18_07385 ENOG4105XVF Competence transcription factor EWF18_07435 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EWF18_07455 ENOG4108HUF Transporter EWF18_07465 ENOG4105YB8 TM2 domain containing protein EWF18_07470 ENOG41080E2 ribosomal-protein-alanine acetyltransferase EWF18_07475 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase EWF18_07485 ENOG4105E4F Isochorismate synthase EWF18_07495 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) EWF18_07500 ENOG4108IPT Naphthoate synthase EWF18_07515 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases EWF18_07520 ENOG4105CHM Aminotransferase EWF18_07525 ENOG4108TGC Acyltransferase EWF18_07545 ENOG41082BV acetyltransferase EWF18_07555 ENOG4108KGH TRANSCRIPTIONal EWF18_07560 ENOG4108A04 Beta-lactamase EWF18_07600 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EWF18_07605 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EWF18_07615 ENOG4105VR9 phosphoribosylformylglycinamidine synthase EWF18_07620 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I EWF18_07630 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase EWF18_07640 ENOG4108V3E phosphoribosylglycinamide formyltransferase EWF18_07650 ENOG4105C12 Phosphoribosylglycinamide synthetase EWF18_07655 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) EWF18_07660 ENOG4108JJB ABC transporter EWF18_07665 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein EWF18_07695 ENOG4105DR4 Methyltransferase EWF18_07705 ENOG4105KRI phosphocarrier protein (HPr EWF18_07710 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EWF18_07715 ENOG41067VN Glutaredoxin EWF18_07750 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EWF18_07760 ENOG4107RUY (E1 component), alpha subunit EWF18_07765 ENOG4105CPP Dehydrogenase, E1 component EWF18_07770 ENOG4105C7S Dehydrogenase EWF18_07775 ENOG4107QN2 dihydrolipoyl dehydrogenase EWF18_07795 ENOG4105F38 ABC transporter, permease EWF18_07800 ENOG4105D38 putrescine abc transporter EWF18_07805 ENOG4107RUE extracellular solute-binding protein family 1 EWF18_07830 ENOG4105ECY inositol monophosphatase EWF18_07840 ENOG4105CI3 gtp-binding protein typa EWF18_07860 ENOG4105CNI cell division protein FtsW EWF18_07915 ENOG4106H78 methyltransferase EWF18_07950 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) EWF18_07990 ENOG4108RWN rrna methyltransferase EWF18_08035 ENOG4105DCG PHP domain protein EWF18_08060 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit EWF18_08070 ENOG4105E33 succinate dehydrogenase EWF18_08080 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EWF18_08140 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity EWF18_08185 ENOG4105CSX c4-dicarboxylate anaerobic carrier EWF18_08245 ENOG41068DC Essential cell division protein (By similarity) EWF18_08250 ENOG4105CJN penicillin-binding protein EWF18_08265 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) EWF18_08270 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EWF18_08275 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EWF18_08285 ENOG4105DFA alanine racemase domain protein EWF18_08295 ENOG41067XK integral membrane protein EWF18_08315 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase EWF18_08335 ENOG4105C34 Pseudouridine synthase EWF18_08355 ENOG4105CD3 dihydroorotase EWF18_08360 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EWF18_08375 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) EWF18_08390 ENOG4105F23 Fibronectin-binding protein EWF18_08405 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EWF18_08410 ENOG4105C25 Primosomal protein n' EWF18_08435 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EWF18_08445 ENOG4108ZF3 Phosphatase EWF18_08455 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EWF18_08460 ENOG4105DJV ribulose-phosphate 3-epimerase EWF18_08475 ENOG4108ZAA Alkaline-shock protein EWF18_08485 ENOG4105CB5 ATP-dependent DNA helicase recG EWF18_08500 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EWF18_08505 ENOG4105CHR reductase EWF18_08530 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EWF18_08575 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) EWF18_08605 ENOG4105C79 DNA protecting protein DprA EWF18_08680 ENOG4105KNE Phosphatidate cytidylyltransferase EWF18_08685 ENOG4105DZP Membrane-associated zinc metalloprotease EWF18_08710 ENOG4105CHV Transcription elongation factor NusA EWF18_08715 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination EWF18_08740 ENOG4105DTN riboflavin biosynthesis protein ribF EWF18_08765 ENOG4105CNU cell division protein FtsK EWF18_08770 ENOG4105FDP GntR family transcriptional regulator EWF18_08785 ENOG4108RKS Short-chain dehydrogenase reductase Sdr EWF18_08800 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EWF18_08805 ENOG4105CEV competence damage-inducible protein EWF18_08825 ENOG4105D48 metallophosphoesterase EWF18_08830 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein EWF18_08835 ENOG4105DQU oxidoreductase, subunit beta EWF18_08870 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator EWF18_08875 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) EWF18_08900 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) EWF18_08905 ENOG4108V06 Glutathione peroxidase EWF18_08910 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EWF18_08915 ENOG4105CXI aluminum resistance protein EWF18_08925 ENOG4105C5F glutamine synthetase EWF18_09020 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EWF18_09025 ENOG4108M15 ABC transporter EWF18_09040 ENOG4108S01 response regulator EWF18_09065 ENOG4105CFH Aspartokinase EWF18_09070 ENOG4105D6E homoserine dehydrogenase EWF18_09075 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) EWF18_09100 ENOG4108IQI permease EWF18_09130 ENOG4105K4I Scp-like extracellular EWF18_09185 ENOG4105C94 Transporter EWF18_09195 ENOG4108I0Z Aconitate hydratase EWF18_09225 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EWF18_09230 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EWF18_09265 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EWF18_09270 ENOG4108RCF TRANSCRIPTIONal EWF18_09280 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EWF18_09290 ENOG4105DER m42 family EWF18_09295 ENOG4105CRQ synthase (Component I) EWF18_09300 ENOG4105DDQ anthranilate synthase EWF18_09330 ENOG4108RMH femAB family EWF18_09335 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) EWF18_09370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EWF18_09375 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EWF18_09415 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EWF18_09490 ENOG4105DPN Oligoendopeptidase f EWF18_09495 ENOG4108UTW Plays a role in the regulation of phosphate uptake EWF18_09505 ENOG4105E2Z phosphate ABC transporter (Permease EWF18_09510 ENOG4105C8U phosphate abc transporter EWF18_09530 ENOG4105C5H ABC transporter EWF18_09535 ENOG4105CFH Aspartokinase EWF18_09540 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EWF18_09565 ENOG4108XFP Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EWF18_09570 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EWF18_09615 ENOG4107T89 von Willebrand factor, type A EWF18_09635 ENOG4105C7S Dehydrogenase EWF18_09665 ENOG410841Q phosphoesterase PA-phosphatase related protein EWF18_09695 ENOG4105C5Y PTS System EWF18_09705 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EWF18_09715 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) EWF18_09770 ENOG4107R7I amino acid EWF18_09790 ENOG410890F Dynamin family EWF18_09805 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) EWF18_09845 ENOG4105BZ4 penicillin-binding protein EWF18_09855 ENOG4105CSM endonuclease III EWF18_09885 ENOG4105CPK Glycosyl transferase (Group 1 EWF18_09890 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase EWF18_09940 ENOG4105EAH synthase EWF18_09960 ENOG4105K70 DNA-binding protein EWF18_09975 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EWF18_09985 ENOG4105HDK L-asparaginase EWF18_09990 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase EWF18_10005 ENOG4105C9U ATP-dependent DNA helicase RecQ EWF18_10055 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase EWF18_10155 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EWF18_10210 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) EWF18_10265 ENOG4106CVF DNA replication protein EWF18_10335 ENOG4108ZUE Phage regulatory protein rha EWF18_10370 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) EWF18_10385 ENOG4105BZU Histidine kinase EWF18_10390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EWF18_10395 ENOG4105FE9 pseudouridine synthase EWF18_10415 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EWF18_10420 ENOG4105I3K Ferric uptake regulator, Fur family EWF18_10425 ENOG4108YZ4 nudix hydrolase EWF18_10430 ENOG4105CPC Aldo Keto reductase EWF18_10440 ENOG4105PDP Short chain dehydrogenase EWF18_10445 ENOG4105II7 pyrroline-5-carboxylate reductase EWF18_10455 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase EWF18_10495 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EWF18_10505 ENOG4108QEG Membrane EWF18_10515 ENOG4105C7S Dehydrogenase EWF18_10520 ENOG4105CPP Dehydrogenase, E1 component EWF18_10535 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EWF18_10565 ENOG4108ZSR alkaline shock protein EWF18_10570 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EWF18_10585 ENOG4105DC7 peptidase M24 EWF18_10600 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) EWF18_10605 ENOG4105WZW rhodanese family EWF18_10650 ENOG4106855 Competence protein EWF18_10655 ENOG4105D7Q type ii secretion system EWF18_10665 ENOG4105C5X domain protein EWF18_10690 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EWF18_10700 ENOG4107RF6 penicillin-binding protein EWF18_10710 ENOG4105N80 Ferric uptake regulator, Fur family EWF18_10715 ENOG4105FAV ABC, transporter EWF18_10720 ENOG4105FDK ABC transporter EWF18_10730 ENOG4105C1J atp-dependent rna helicase EWF18_10735 ENOG4105EGD dinuclear metal center protein, YbgI family EWF18_10745 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EWF18_10750 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EWF18_10780 ENOG4105KG3 cytidine deaminase EWF18_10795 ENOG4105C9A Phoh family EWF18_10810 ENOG4105F7J membrane-bound serine protease EWF18_10820 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EWF18_10825 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EWF18_10855 ENOG4105CSA Coproporphyrinogen iii oxidase EWF18_10875 ENOG4105TQK DNA polymerase iii, delta' subunit EWF18_10880 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 EWF18_10885 ENOG4108UK2 deaminase EWF18_10895 ENOG4105DXX methyltransferase EWF18_10900 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) EWF18_10905 ENOG4108WF2 Metal Dependent Phosphohydrolase EWF18_10915 ENOG410812S Rna-binding protein EWF18_10925 ENOG4105CQW ribosome biogenesis GTPase YqeH EWF18_10930 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase EWF18_10965 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EWF18_10970 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein EWF18_10980 ENOG4105P4J Allophanate hydrolase, subunit 1 EWF18_10995 ENOG4105CFP Peptidase U32 EWF18_11000 ENOG4105XYU peptidase (U32 family) EWF18_11030 ENOG4105C7H Helicase, RecD TraA family EWF18_11045 ENOG4105C3J Cysteine desulfurase EWF18_11050 ENOG4105DEN Luciferase family EWF18_11070 ENOG4105D1H recombination factor protein RarA EWF18_11075 ENOG4105CUZ uba thif-type nad fad binding protein EWF18_11120 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EWF18_11125 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EWF18_11130 ENOG4105VIE preprotein translocase, subunit YajC EWF18_11170 ENOG4105X36 (ribosomal) protein EWF18_11225 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EWF18_11235 ENOG4108R3E Dna-3-methyladenine glycosylase i EWF18_11255 ENOG4105D52 delta-aminolevulinic acid dehydratase EWF18_11305 ENOG4105U6W MutT NUDIX family protein EWF18_11330 ENOG4108IQI permease EWF18_11360 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EWF18_11370 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EWF18_11375 ENOG4105C2M dna polymerase I EWF18_11385 ENOG4105BZU Histidine kinase EWF18_11390 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EWF18_11405 ENOG4105BZN citrate synthase EWF18_11410 ENOG4105C85 amino acid EWF18_11440 ENOG4105C6K Malic enzyme EWF18_11450 ENOG4105SFS phosphoesterase RecJ domain protein EWF18_11505 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) EWF18_11510 ENOG4105EJ9 Membrane EWF18_11555 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EWF18_11560 ENOG4108X3M OsmC Ohr family protein EWF18_11565 ENOG4105C5R Aminotransferase EWF18_11570 ENOG4108JQ1 Dehydrogenase EWF18_11595 ENOG4105F6E Acyl-transferase EWF18_11600 ENOG4105C0H protease EWF18_11630 ENOG4105CKU formyltetrahydrofolate synthetase EWF18_11640 ENOG4105F1V Acetoin utilization protein EWF18_11645 ENOG4105DGU Histone deacetylase EWF18_11650 ENOG4105ETE Transcriptional regulator (LacI family EWF18_11660 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase EWF18_11695 ENOG4108VDD TRNA binding domain protein EWF18_11720 ENOG4105C8F Beta-lactamase domain protein EWF18_11730 ENOG4108V15 phosphotransferase enzyme family EWF18_11735 ENOG4105F0I Aminotransferase EWF18_11760 ENOG4105CBX hi0933 family EWF18_11780 ENOG410605W Major Facilitator EWF18_11785 ENOG4105N5T Radical SAM Protein EWF18_11805 ENOG4105E8V Alpha Beta Hydrolase Fold protein EWF18_11830 ENOG4108R6K riboflavin synthase, subunit alpha EWF18_11835 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EWF18_11850 ENOG4107R3E Citrate transporter EWF18_11865 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis EWF18_11895 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EWF18_11905 ENOG4106A8V Protein CrcB homolog EWF18_11910 ENOG4106A8V Protein CrcB homolog EWF18_11915 ENOG4105CV8 reductase EWF18_12160 ENOG4105C1Q protoporphyrinogen oxidase EWF18_12195 ENOG4105K59 histidine triad (HIT) protein EWF18_12230 ENOG4107VRP DNA repair exonuclease EWF18_12260 ENOG4105WH1 Two component transcriptional regulator luxr family EWF18_12265 ENOG4105BZU Histidine kinase EWF18_12270 ENOG4108YBP pseudouridine synthase EWF18_12310 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EWF18_12315 ENOG4105CDA abc transporter atp-binding protein EWF18_12320 ENOG4105E5Q amino acid AbC transporter EWF18_12485 ENOG4108M3J Dehydrogenase EWF18_12490 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EWF18_12500 ENOG4107NBY Membrane EWF18_12525 ENOG41067AE Membrane-bound metal-dependent hydrolase EWF18_12540 ENOG4105EY8 ABC transporter EWF18_12580 ENOG4108S4H thioesterase Superfamily protein EWF18_12610 ENOG4105WH1 Two component transcriptional regulator luxr family EWF18_12680 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EWF18_12735 ENOG4105C4R Atp-dependent dna helicase EWF18_12740 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) EWF18_12745 ENOG4105KGF protein, YerC YecD EWF18_12760 ENOG4107DDB Cysteine protease able to EWF18_12785 ENOG4105DAP Nicotinate phosphoribosyltransferase EWF18_12790 ENOG4107QN4 Catalyzes the production of nitric oxide (By similarity) EWF18_12795 ENOG4105CQC Prephenate dehydratase EWF18_12805 ENOG4105C8P )-transporter EWF18_12830 ENOG4105C26 Dehydrogenase EWF18_12840 ENOG4108FPN Integrase EWF18_12845 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EWF18_12920 ENOG4105CJ1 ABC, transporter EWF18_12935 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EWF18_12965 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) EWF18_13080 ENOG4108WCX response regulator EWF18_13105 ENOG4105BZU Histidine kinase EWF18_13115 ENOG4105CUC YeeE YedE family protein EWF18_13125 ENOG4105C5H ABC transporter EWF18_13135 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) EWF18_13145 ENOG410801F ribosomal-protein-alanine acetyltransferase EWF18_13150 ENOG41072GX Peptidase M22 Glycoprotease EWF18_13155 ENOG4105K8N protein family UPF0079, ATPase EWF18_13170 ENOG4105C7K acetolactate synthase EWF18_13190 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EWF18_13260 ENOG4105WN5 stage II sporulation protein EWF18_13265 ENOG4107SGM protein serine threonine phosphatase EWF18_13285 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EWF18_13300 ENOG4105CKV Membrane EWF18_13315 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EWF18_13330 ENOG4105C08 Histidine kinase EWF18_13335 ENOG4105EEX Two component transcriptional regulator (Winged helix family EWF18_13345 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) EWF18_13370 ENOG4105VPX protein, conserved in bacteria EWF18_13375 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EWF18_13435 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EWF18_13495 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EWF18_13520 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EWF18_13525 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EWF18_13535 ENOG4107104 thymidine kinase EWF18_13550 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EWF18_13570 ENOG4105D2N Aldolase EWF18_13595 ENOG4105HNY Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) EWF18_13625 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) EWF18_13635 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EWF18_13640 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EWF18_13645 ENOG4108RMU ferritin dps family protein EWF18_13665 ENOG4105DG6 mannose-6-phosphate isomerase EWF18_13680 ENOG4105PGM cation diffusion facilitator family transporter EWF18_13715 ENOG4105DKW ABC transporter EWF18_13720 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EWF18_13725 ENOG4105CTS PTS system mannitol-specific EWF18_13730 ENOG4105ETD TRANSCRIPTIONal EWF18_13735 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein EWF18_13760 ENOG4105C8B TIGR00159 family EWF18_13765 ENOG4105CYW agmatinase EWF18_13820 ENOG4105D1F ATP-binding protein EWF18_13845 ENOG4108MYC UTP-glucose-1-phosphate uridylyltransferase EWF18_13850 ENOG4107K5X Membrane-bound metal-dependent hydrolase EWF18_13860 ENOG4105DWD nucleoside recognition domain protein EWF18_13865 ENOG4108U1V ABC transporter, permease EWF18_13870 ENOG4105DQ5 transport system permease protein EWF18_13885 ENOG4106M28 alanine racemase domain protein EWF18_13895 ENOG4107SFI Major Facilitator superfamily EWF18_13920 ENOG4105C94 Transporter EWF18_13925 ENOG4105CIS alcohol dehydrogenase EWF18_13930 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein EWF18_13945 ENOG4105CK1 PTS System EWF18_13950 ENOG4105VCP PTS System EWF18_13975 ENOG4105E98 transcriptional regulator DeoR family EWF18_13980 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EWF18_14005 ENOG4105VUF Transcriptional regulator EWF18_14015 ENOG4106AM8 polysaccharide lyase family 8 EWF18_14035 ENOG4107FQX Alpha-acetolactate decarboxylase EWF18_14075 ENOG4108JJB ABC transporter EWF18_14110 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) EWF18_14115 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EWF18_14230 ENOG4105C7N Xanthine uracil vitamin C permease EWF18_14250 ENOG4105CSC Glucose uptake protein EWF18_14330 ENOG4108ZAF Molybdopterin EWF18_14335 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein EWF18_14350 ENOG4105EPU Molybdenum cofactor synthesis domain protein EWF18_14355 ENOG4105D06 uba thif-type nad fad binding protein EWF18_14360 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) EWF18_14365 ENOG4105E0C molybdate abc transporter EWF18_14385 ENOG4107ZYJ bioY protein EWF18_14400 ENOG4105FDT acyl-CoA dehydrogenase EWF18_14480 ENOG4105DFD Na H antiporter EWF18_14515 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis EWF18_14585 ENOG4107YBY Hydrolase EWF18_14590 ENOG4105C09 Bile acid EWF18_14600 ENOG4105CI1 PTS System EWF18_14605 ENOG4108Q3X Transcriptional regulator EWF18_14625 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EWF18_14630 ENOG4105CH2 amidohydrolase EWF18_14640 ENOG4105CGP Urocanate hydratase EWF18_14645 ENOG4105C5Q Transcriptional regulator EWF18_14665 ENOG4105E66 phosphoriboisomerase A EWF18_14670 ENOG4108RPX mosc domain containing protein EWF18_14695 ENOG4108IUX (ABC) transporter EWF18_14700 ENOG4105KAF membrAne EWF18_14725 ENOG4105D7N magnesium and cobalt transport protein CorA EWF18_14755 ENOG4105CW7 secretion protein, HlyD family EWF18_14785 ENOG41062A4 Transcriptional regulator