locus-tag	class	description
EWF18_00030	COG1620	l-lactate permease
EWF18_00050	COG0604	alcohol dehydrogenase
EWF18_00100	COG1511	domain protein
EWF18_00115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EWF18_00115	COG1263	PTS System
EWF18_00130	COG3871	stress protein (general stress protein 26)
EWF18_00175	COG0789	Transcriptional regulator
EWF18_00195	COG2181	nitrate reductase activity
EWF18_00205	COG1140	nitrate reductase beta subunit
EWF18_00210	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EWF18_00220	COG2146	nitrite reductase [NAD(P)H] activity
EWF18_00225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EWF18_00235	COG0454	-acetyltransferase
EWF18_00240	COG2116	formate transmembrane transporter activity
EWF18_00255	COG0803	Belongs to the bacterial solute-binding protein 9 family
EWF18_00255	COG3443	Belongs to the bacterial solute-binding protein 9 family
EWF18_00290	COG1126	abc transporter atp-binding protein
EWF18_00295	COG0765	amino acid transport
EWF18_00300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EWF18_00305	COG2814	Major facilitator Superfamily
EWF18_00320	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EWF18_00380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EWF18_00385	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EWF18_00395	COG1132	(ABC) transporter
EWF18_00420	COG1929	Belongs to the glycerate kinase type-1 family
EWF18_00430	COG2814	Major facilitator Superfamily
EWF18_00450	COG1113	amino acid transport
EWF18_00465	COG0531	amino acid
EWF18_00485	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EWF18_00495	COG1174	glycine betaine transport
EWF18_00505	COG1174	glycine betaine transport
EWF18_00525	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
EWF18_00535	COG0531	amino acid
EWF18_00540	COG2272	Belongs to the type-B carboxylesterase lipase family
EWF18_00545	COG2814	Major facilitator Superfamily
EWF18_00550	COG0390	transport system, permease component
EWF18_00555	COG4619	ABC transporter
EWF18_00580	COG4808	Protein conserved in bacteria
EWF18_00585	COG0069	glutamate synthase activity
EWF18_00615	COG0601	transmembrane transport
EWF18_00650	COG1028	Short-chain dehydrogenase reductase Sdr
EWF18_00655	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EWF18_00660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EWF18_00745	COG0494	nUDIX hydrolase
EWF18_00790	COG1846	Transcriptional regulator
EWF18_00825	COG1070	Carbohydrate kinase
EWF18_00830	COG1802	Transcriptional regulator
EWF18_00835	COG0789	Transcriptional regulator
EWF18_00840	COG2357	RelA SpoT domain protein
EWF18_00845	COG4876	unkown
EWF18_00855	COG2271	Major facilitator Superfamily
EWF18_00860	COG0586	Pfam SNARE associated Golgi protein
EWF18_00880	COG1131	(ABC) transporter
EWF18_00900	COG0400	carboxylic ester hydrolase activity
EWF18_00905	COG0346	lactoylglutathione lyase activity
EWF18_00910	COG1846	Transcriptional regulator
EWF18_00920	COG2514	catechol 2,3-dioxygenase activity
EWF18_00935	COG0561	phosphatase activity
EWF18_00940	COG1131	(ABC) transporter
EWF18_00950	COG3764	Sortase (surface protein transpeptidase)
EWF18_00970	COG1760	l-serine dehydratase
EWF18_00975	COG1760	l-serine dehydratase
EWF18_00990	COG0697	spore germination
EWF18_00995	COG0657	acetylesterase activity
EWF18_01015	COG0028	Belongs to the TPP enzyme family
EWF18_01020	COG1346	cytolysis
EWF18_01030	COG0583	DNA-binding transcription factor activity
EWF18_01040	COG3942	CHAP domain
EWF18_01050	COG3425	synthase
EWF18_01055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EWF18_01080	COG2409	Drug exporters of the RND superfamily
EWF18_01125	COG0436	Aminotransferase
EWF18_01160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EWF18_01160	COG2755	lipolytic protein G-D-S-L family
EWF18_01270	COG0167	dihydroorotate dehydrogenase activity
EWF18_01325	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EWF18_01330	COG3527	Alpha-acetolactate decarboxylase
EWF18_01345	COG0531	amino acid
EWF18_01375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EWF18_01415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EWF18_01440	COG2851	Citrate transporter
EWF18_01450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EWF18_01460	COG0386	Belongs to the glutathione peroxidase family
EWF18_01485	COG1136	(ABC) transporter
EWF18_01490	COG2205	protein histidine kinase activity
EWF18_01495	COG0745	RESPONSE REGULATOR receiver
EWF18_01505	COG1785	Belongs to the alkaline phosphatase family
EWF18_01520	COG1846	Transcriptional regulator
EWF18_01530	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EWF18_01530	COG4932	domain protein
EWF18_01555	COG2235	arginine
EWF18_01585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWF18_01585	COG3711	transcriptional antiterminator
EWF18_01590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWF18_01590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EWF18_01590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EWF18_01595	COG1482	cell wall glycoprotein biosynthetic process
EWF18_01605	COG3942	CHAP domain
EWF18_01605	COG1705	Flagellar rod assembly protein muramidase FlgJ
EWF18_01610	COG3433	isochorismatase activity
EWF18_01610	COG1535	isochorismatase
EWF18_01625	COG0438	transferase activity, transferring glycosyl groups
EWF18_01640	COG1073	alpha beta
EWF18_01650	COG0201	protein transport
EWF18_01660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EWF18_01685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EWF18_01715	COG1309	transcriptional regulator
EWF18_01720	COG1215	transferase activity, transferring glycosyl groups
EWF18_01730	COG0726	polysaccharide deacetylase
EWF18_01735	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
EWF18_01780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EWF18_01860	COG0471	metal ion transport
EWF18_01865	COG2962	Rard protein
EWF18_01875	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
EWF18_01890	COG1136	(ABC) transporter
EWF18_01895	COG0577	efflux transmembrane transporter activity
EWF18_01930	COG1278	Cold shock
EWF18_01950	COG1475	DNA binding
EWF18_01990	COG2501	S4 domain
EWF18_02010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EWF18_02040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EWF18_02050	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EWF18_02095	COG4863	YycH protein
EWF18_02105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EWF18_02110	COG0737	Belongs to the 5'-nucleotidase family
EWF18_02125	COG3316	Transposase and inactivated derivatives
EWF18_02140	COG0584	glycerophosphoryl diester phosphodiesterase
EWF18_02150	COG3425	synthase
EWF18_02225	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EWF18_02255	COG0456	acetyltransferase
EWF18_02280	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EWF18_02285	COG3421	Type III restriction
EWF18_02320	COG3328	transposase activity
EWF18_02345	COG0730	response to heat
EWF18_02350	COG1937	Protein conserved in bacteria
EWF18_02355	COG2210	Belongs to the sulfur carrier protein TusA family
EWF18_02360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EWF18_02410	COG0823	Involved in the tonB-independent uptake of proteins
EWF18_02455	COG1473	amidohydrolase
EWF18_02470	COG1283	sodium-dependent phosphate transmembrane transporter activity
EWF18_02475	COG4716	Myosin-crossreactive antigen
EWF18_02485	COG1620	l-lactate permease
EWF18_02505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EWF18_02510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EWF18_02515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EWF18_02525	COG2423	ornithine cyclodeaminase activity
EWF18_02530	COG4264	IucA IucC family
EWF18_02535	COG2814	Major facilitator Superfamily
EWF18_02540	COG4264	IucA IucC family
EWF18_02545	COG4264	IucA IucC family
EWF18_02555	COG0019	diaminopimelate decarboxylase activity
EWF18_02560	COG1475	DNA binding
EWF18_02590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EWF18_02595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EWF18_02600	COG0438	transferase activity, transferring glycosyl groups
EWF18_02635	COG0813	purine-nucleoside phosphorylase activity
EWF18_02640	COG2814	Major facilitator Superfamily
EWF18_02660	COG3639	organic phosphonate transmembrane transporter activity
EWF18_02680	COG0737	Belongs to the 5'-nucleotidase family
EWF18_02695	COG1454	alcohol dehydrogenase
EWF18_02695	COG1012	belongs to the aldehyde dehydrogenase family
EWF18_02720	COG1086	Polysaccharide biosynthesis protein
EWF18_02730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EWF18_02760	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EWF18_02770	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EWF18_02775	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EWF18_02785	COG2832	Protein of unknown function (DUF454)
EWF18_02820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EWF18_02830	COG5609	conserved protein (DUF2294)
EWF18_02880	COG1114	Component of the transport system for branched-chain amino acids
EWF18_02885	COG1335	isochorismatase
EWF18_02890	COG3961	Belongs to the TPP enzyme family
EWF18_02920	COG1737	Transcriptional regulator
EWF18_02960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EWF18_02970	COG0405	Gamma-glutamyltransferase
EWF18_03000	COG1175	transmembrane transport
EWF18_03005	COG3833	ABC-type maltose transport systems, permease component
EWF18_03015	COG0673	inositol 2-dehydrogenase activity
EWF18_03020	COG0673	inositol 2-dehydrogenase activity
EWF18_03030	COG1755	Isoprenylcysteine carboxyl methyltransferase
EWF18_03090	COG0183	Belongs to the thiolase family
EWF18_03100	COG1960	acyl-CoA dehydrogenase activity
EWF18_03105	COG0318	PFAM AMP-dependent synthetase and ligase
EWF18_03120	COG0747	negative chemotaxis
EWF18_03125	COG3189	MarR family transcriptional regulator
EWF18_03160	COG1263	PTS System
EWF18_03160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EWF18_03160	COG2190	(PTS) system
EWF18_03165	COG1957	nucleoside hydrolase
EWF18_03185	COG3414	Phosphotransferase system galactitol-specific IIB component
EWF18_03190	COG3775	system Galactitol-specific IIC component
EWF18_03195	COG1063	alcohol dehydrogenase
EWF18_03205	COG1063	alcohol dehydrogenase
EWF18_03210	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EWF18_03215	COG1063	alcohol dehydrogenase
EWF18_03220	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EWF18_03225	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EWF18_03235	COG1063	alcohol dehydrogenase
EWF18_03240	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EWF18_03280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EWF18_03290	COG2190	(PTS) system
EWF18_03290	COG1263	PTS System
EWF18_03290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EWF18_03295	COG2723	6-phospho-beta-galactosidase activity
EWF18_03300	COG2226	methyltransferase
EWF18_03350	COG0739	heme binding
EWF18_03355	COG1131	(ABC) transporter
EWF18_03375	COG3942	CHAP domain
EWF18_03375	COG1388	LysM domain
EWF18_03490	COG1114	Component of the transport system for branched-chain amino acids
EWF18_03500	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EWF18_03510	COG0577	efflux transmembrane transporter activity
EWF18_03540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EWF18_03545	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EWF18_03595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EWF18_03625	COG3037	sugar-specific permease SgaT UlaA
EWF18_03635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWF18_03665	COG2271	Major facilitator Superfamily
EWF18_03670	COG0346	lactoylglutathione lyase activity
EWF18_03675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EWF18_03680	COG0431	NADPH-dependent FMN reductase
EWF18_03695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EWF18_03700	COG2822	iron ion transport
EWF18_03705	COG2837	iron assimilation
EWF18_03710	COG0672	)-iron permease
EWF18_03715	COG0805	protein transport
EWF18_03720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EWF18_03730	COG1476	TRANSCRIPTIONal
EWF18_03770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EWF18_03770	COG0646	methionine synthase
EWF18_03775	COG0626	cystathionine gamma-synthase activity
EWF18_03780	COG0626	cystathionine gamma-synthase activity
EWF18_03790	COG1475	DNA binding
EWF18_03795	COG0668	transmembrane transport
EWF18_03800	COG4481	Protein conserved in bacteria
EWF18_03805	COG0012	GTP binding
EWF18_03840	COG4974	Belongs to the 'phage' integrase family
EWF18_03915	COG1823	symporter activity
EWF18_03950	COG2233	PERMEase
EWF18_04040	COG3759	membrane
EWF18_04230	COG0523	cobalamin synthesis protein
EWF18_04255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EWF18_04260	COG3002	Belongs to the UPF0753 family
EWF18_04265	COG5609	conserved protein (DUF2294)
EWF18_04280	COG1647	Serine aminopeptidase, S33
EWF18_04295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EWF18_04300	COG0626	cystathionine gamma-synthase activity
EWF18_04310	COG2011	ABC-type metal ion transport system permease component
EWF18_04315	COG1464	Belongs to the NlpA lipoprotein family
EWF18_04350	COG0583	DNA-binding transcription factor activity
EWF18_04360	COG0493	'glutamate synthase
EWF18_04375	COG1263	PTS System
EWF18_04375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EWF18_04380	COG0366	Alpha amylase catalytic
EWF18_04385	COG2188	Transcriptional regulator
EWF18_04405	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EWF18_04410	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EWF18_04445	COG1982	Orn Lys Arg decarboxylase major
EWF18_04455	COG3870	Protein conserved in bacteria
EWF18_04460	COG0470	DNA polymerase III
EWF18_04465	COG1774	PSP1 C-terminal conserved region
EWF18_04475	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EWF18_04485	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EWF18_04495	COG0084	hydrolase, TatD family'
EWF18_04500	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EWF18_04510	COG4466	Protein conserved in bacteria
EWF18_04520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EWF18_04525	COG0251	oxidation-reduction process
EWF18_04570	COG2244	polysaccharide biosynthetic process
EWF18_04575	COG3956	TIGRFAM MazG family protein
EWF18_04580	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EWF18_04590	COG1098	S1 RNA binding domain
EWF18_04605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EWF18_04630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EWF18_04725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EWF18_04740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EWF18_04750	COG3880	PFAM UvrB UvrC protein
EWF18_04765	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EWF18_04770	COG4956	integral membrane protein (PIN domain superfamily)
EWF18_04795	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
EWF18_04820	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EWF18_04825	COG0250	Participates in transcription elongation, termination and antitermination
EWF18_04855	COG2813	Specifically methylates the guanine in position
EWF18_04865	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EWF18_04895	COG1473	amidohydrolase
EWF18_04925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EWF18_04930	COG1428	Deoxynucleoside kinase
EWF18_04935	COG1428	Deoxynucleoside kinase
EWF18_04945	COG0561	phosphatase activity
EWF18_05005	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EWF18_05105	COG0095	Lipoate-protein ligase
EWF18_05110	COG0083	homoserine kinase activity
EWF18_05130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EWF18_05195	COG0667	Aldo Keto reductase
EWF18_05200	COG0655	NAD(P)H dehydrogenase (quinone) activity
EWF18_05210	COG1078	dGTPase activity
EWF18_05250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EWF18_05280	COG2267	carboxylic ester hydrolase activity
EWF18_05305	COG4974	Belongs to the 'phage' integrase family
EWF18_05355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EWF18_05360	COG1121	(ABC) transporter
EWF18_05365	COG1321	iron dependent repressor
EWF18_05375	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EWF18_05385	COG1682	transport, permease protein
EWF18_05390	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EWF18_05400	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EWF18_05405	COG1686	Belongs to the peptidase S11 family
EWF18_05410	COG1132	(ABC) transporter
EWF18_05415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EWF18_05425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EWF18_05430	COG1120	ATPase activity
EWF18_05435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EWF18_05440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EWF18_05445	COG2376	Dihydroxyacetone kinase
EWF18_05455	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
EWF18_05465	COG3949	Membrane
EWF18_05505	COG1136	(ABC) transporter
EWF18_05510	COG0577	efflux transmembrane transporter activity
EWF18_05515	COG1392	Phosphate transport regulator
EWF18_05520	COG0306	phosphate transporter
EWF18_05525	COG3942	CHAP domain
EWF18_05525	COG1388	LysM domain
EWF18_05535	COG4977	sequence-specific DNA binding
EWF18_05535	COG1917	Cupin 2, conserved barrel domain protein
EWF18_05565	COG0583	DNA-binding transcription factor activity
EWF18_05575	COG2814	Major facilitator Superfamily
EWF18_05580	COG2839	Protein conserved in bacteria
EWF18_05610	COG1611	Belongs to the LOG family
EWF18_05630	COG4988	ABC transporter
EWF18_05640	COG1846	Transcriptional regulator
EWF18_05645	COG0523	cobalamin synthesis protein
EWF18_05650	COG4989	oxidoreductase activity
EWF18_05660	COG0471	metal ion transport
EWF18_05695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EWF18_05700	COG1349	DNA-binding transcription factor activity
EWF18_05705	COG1105	Belongs to the carbohydrate kinase PfkB family
EWF18_05710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWF18_05710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EWF18_05710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EWF18_05715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EWF18_05720	COG1253	flavin adenine dinucleotide binding
EWF18_05725	COG0656	L-ascorbic acid biosynthetic process
EWF18_05730	COG0463	Glycosyl transferase, family 2
EWF18_05765	COG0720	synthase
EWF18_05775	COG0512	Glutamine amidotransferase of anthranilate synthase
EWF18_05775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EWF18_05780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EWF18_05810	COG0488	(ABC) transporter
EWF18_05815	COG0514	ATP-dependent DNA helicase (RecQ)
EWF18_05820	COG1125	glycine betaine transport
EWF18_05820	COG0517	IMP dehydrogenase activity
EWF18_05855	COG3104	oligopeptide transport
EWF18_05885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EWF18_05890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EWF18_05900	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EWF18_05905	COG4605	iron ion homeostasis
EWF18_05910	COG4604	ABC transporter, ATP-binding protein
EWF18_05915	COG4607	ABC-type enterochelin transport system periplasmic component
EWF18_05970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EWF18_05975	COG1739	Uncharacterized protein family UPF0029
EWF18_05985	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EWF18_05990	COG1040	competence protein
EWF18_06020	COG1388	LysM domain
EWF18_06020	COG3942	CHAP domain
EWF18_06080	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EWF18_06150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EWF18_06155	COG1647	Serine aminopeptidase, S33
EWF18_06255	COG3728	DNA packaging
EWF18_06255	COG5484	DNA packaging
EWF18_06350	COG1278	Cold shock
EWF18_06390	COG0406	alpha-ribazole phosphatase activity
EWF18_06395	COG1279	arginine transmembrane transporter activity
EWF18_06420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EWF18_06425	COG1393	Belongs to the ArsC family
EWF18_06440	COG3878	Protein conserved in bacteria
EWF18_06450	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EWF18_06465	COG2011	ABC-type metal ion transport system permease component
EWF18_06470	COG1464	Belongs to the NlpA lipoprotein family
EWF18_06485	COG0396	ATPase activity
EWF18_06490	COG0719	Fe-S assembly protein
EWF18_06500	COG0822	iron-sulfur transferase activity
EWF18_06525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EWF18_06595	COG1484	DNA-dependent DNA replication
EWF18_06690	COG1783	phage Terminase large subunit
EWF18_06820	COG1388	LysM domain
EWF18_06820	COG5632	N-Acetylmuramoyl-L-alanine amidase
EWF18_06850	COG1253	flavin adenine dinucleotide binding
EWF18_06860	COG1801	Protein of unknown function DUF72
EWF18_06865	COG0730	response to heat
EWF18_06880	COG4470	Protein conserved in bacteria
EWF18_06890	COG2445	Protein of unknown function DUF86
EWF18_06920	COG1696	Membrane protein involved in D-alanine export
EWF18_06930	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EWF18_06935	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EWF18_06940	COG4837	Protein of unknown function (DUF1462)
EWF18_06945	COG1252	NADH dehydrogenase
EWF18_06955	COG0316	Belongs to the HesB IscA family
EWF18_06965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EWF18_06970	COG2056	Na+-H+ antiporter family
EWF18_06975	COG2050	protein possibly involved in aromatic compounds catabolism
EWF18_07030	COG1098	S1 RNA binding domain
EWF18_07035	COG1902	pentaerythritol trinitrate reductase activity
EWF18_07050	COG0584	glycerophosphoryl diester phosphodiesterase
EWF18_07070	COG0398	Pfam SNARE associated Golgi protein
EWF18_07090	COG1074	ATP-dependent DNA helicase activity
EWF18_07110	COG0561	phosphatase activity
EWF18_07150	COG1881	PFAM PEBP family protein
EWF18_07180	COG0601	transmembrane transport
EWF18_07185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EWF18_07190	COG0444	Belongs to the ABC transporter superfamily
EWF18_07195	COG4608	Belongs to the ABC transporter superfamily
EWF18_07200	COG4166	transmembrane transport
EWF18_07210	COG0444	Belongs to the ABC transporter superfamily
EWF18_07215	COG4608	Belongs to the ABC transporter superfamily
EWF18_07220	COG0601	transmembrane transport
EWF18_07225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EWF18_07250	COG1164	Oligoendopeptidase f
EWF18_07260	COG2346	COG2346, Truncated hemoglobins
EWF18_07275	COG2357	RelA SpoT domain protein
EWF18_07285	COG0564	pseudouridine synthase activity
EWF18_07290	COG2239	Acts as a magnesium transporter
EWF18_07295	COG0475	glutathione-regulated potassium exporter activity
EWF18_07295	COG0569	domain protein
EWF18_07305	COG0628	permease
EWF18_07350	COG0861	Integral membrane protein TerC family
EWF18_07365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EWF18_07370	COG0737	Belongs to the 5'-nucleotidase family
EWF18_07385	COG4903	ComK protein
EWF18_07400	COG4873	Protein conserved in bacteria
EWF18_07455	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EWF18_07465	COG2314	TM2 domain
EWF18_07470	COG0456	acetyltransferase
EWF18_07475	COG1575	Belongs to the MenA family. Type 1 subfamily
EWF18_07485	COG1169	isochorismate synthase
EWF18_07495	COG2267	carboxylic ester hydrolase activity
EWF18_07520	COG0436	Aminotransferase
EWF18_07525	COG3594	Acyltransferase
EWF18_07545	COG2153	protein acetylation
EWF18_07555	COG1316	TRANSCRIPTIONal
EWF18_07600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EWF18_07615	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EWF18_07655	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EWF18_07660	COG4172	Belongs to the ABC transporter superfamily
EWF18_07665	COG4721	ABC-type cobalt transport system, permease component
EWF18_07695	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EWF18_07715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EWF18_07720	COG1271	oxidase subunit
EWF18_07725	COG1294	oxidase, subunit
EWF18_07795	COG1176	ABC-type spermidine putrescine transport system, permease component I
EWF18_07800	COG1177	transmembrane transport
EWF18_07805	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EWF18_07830	COG0483	inositol monophosphate 1-phosphatase activity
EWF18_07860	COG0772	Belongs to the SEDS family
EWF18_07895	COG3679	Belongs to the UPF0342 family
EWF18_07915	COG0742	ribosomal rna small subunit methyltransferase
EWF18_07990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EWF18_08035	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EWF18_08035	COG1796	DNA polymerase
EWF18_08060	COG2009	succinate dehydrogenase
EWF18_08065	COG1053	succinate dehydrogenase
EWF18_08070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EWF18_08185	COG1288	antiporter activity
EWF18_08220	COG1011	Hydrolase
EWF18_08245	COG4839	cell division protein FtsL
EWF18_08265	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EWF18_08270	COG0849	cell division
EWF18_08275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EWF18_08285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EWF18_08295	COG0762	integral membrane protein
EWF18_08305	COG3599	regulation of cell shape
EWF18_08315	COG2514	catechol 2,3-dioxygenase activity
EWF18_08335	COG0564	pseudouridine synthase activity
EWF18_08345	COG2233	PERMEase
EWF18_08405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EWF18_08410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EWF18_08435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EWF18_08435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EWF18_08445	COG0631	protein serine/threonine phosphatase activity
EWF18_08460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EWF18_08475	COG1302	Protein conserved in bacteria
EWF18_08530	COG0552	protein localization to endoplasmic reticulum
EWF18_08540	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EWF18_08605	COG0758	DNA mediated transformation
EWF18_08635	COG3328	transposase activity
EWF18_08710	COG0195	Participates in both transcription termination and antitermination
EWF18_08715	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EWF18_08740	COG0196	riboflavin kinase activity
EWF18_08770	COG2188	Transcriptional regulator
EWF18_08775	COG0612	Peptidase, M16
EWF18_08780	COG0612	Peptidase, M16
EWF18_08785	COG0300	oxidoreductase activity
EWF18_08805	COG1058	Belongs to the CinA family
EWF18_08805	COG1546	Belongs to the CinA family
EWF18_08825	COG1692	metallophosphoesterase
EWF18_08830	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EWF18_08830	COG0674	pyruvate-flavodoxin oxidoreductase activity
EWF18_08835	COG1013	pyruvate-flavodoxin oxidoreductase activity
EWF18_08870	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EWF18_08875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EWF18_08900	COG1923	regulation of RNA biosynthetic process
EWF18_08915	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EWF18_09025	COG1131	(ABC) transporter
EWF18_09040	COG2197	response regulator
EWF18_09050	COG1525	nuclease
EWF18_09065	COG0527	aspartate kinase activity
EWF18_09070	COG0460	homoserine dehydrogenase
EWF18_09075	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EWF18_09100	COG0833	amino acid
EWF18_09130	COG2340	Cysteine-rich secretory protein family
EWF18_09165	COG4846	Membrane protein involved in cytochrome C biogenesis
EWF18_09185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EWF18_09200	COG0824	Thioesterase
EWF18_09225	COG0187	DNA topoisomerase II activity
EWF18_09255	COG0628	permease
EWF18_09265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EWF18_09270	COG1316	TRANSCRIPTIONal
EWF18_09280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EWF18_09290	COG1363	Peptidase, m42
EWF18_09295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EWF18_09300	COG0512	Glutamine amidotransferase of anthranilate synthase
EWF18_09335	COG2348	transferase activity, transferring amino-acyl groups
EWF18_09350	COG3328	transposase activity
EWF18_09390	COG3316	Transposase and inactivated derivatives
EWF18_09410	COG3316	Transposase and inactivated derivatives
EWF18_09415	COG1968	undecaprenyl-diphosphatase activity
EWF18_09450	COG3173	Aminoglycoside phosphotransferase
EWF18_09485	COG3316	Transposase and inactivated derivatives
EWF18_09495	COG0704	Plays a role in the regulation of phosphate uptake
EWF18_09505	COG0581	inorganic phosphate transmembrane transporter activity
EWF18_09510	COG0573	inorganic phosphate transmembrane transporter activity
EWF18_09530	COG0488	(ABC) transporter
EWF18_09535	COG0527	aspartate kinase activity
EWF18_09540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EWF18_09615	COG4548	von Willebrand factor, type A
EWF18_09665	COG0671	phosphoesterase, PA-phosphatase related
EWF18_09705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EWF18_09745	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EWF18_09770	COG0531	amino acid
EWF18_09785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EWF18_09790	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EWF18_09805	COG0116	Belongs to the methyltransferase superfamily
EWF18_09845	COG4499	WXG100 protein secretion system (Wss), protein YukC
EWF18_09845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EWF18_09855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EWF18_09885	COG0438	transferase activity, transferring glycosyl groups
EWF18_09890	COG1694	Mazg nucleotide pyrophosphohydrolase
EWF18_09895	COG2738	Putative neutral zinc metallopeptidase
EWF18_09900	COG4347	Protein of unknown function (DUF1405)
EWF18_09940	COG0142	geranyltranstransferase activity
EWF18_09990	COG0492	ferredoxin-NADP+ reductase activity
EWF18_10005	COG0514	ATP-dependent DNA helicase (RecQ)
EWF18_10015	COG1141	Ferredoxin
EWF18_10055	COG1388	LysM domain
EWF18_10055	COG0860	N-Acetylmuramoyl-L-alanine amidase
EWF18_10155	COG0740	serine-type endopeptidase activity
EWF18_10265	COG1484	DNA-dependent DNA replication
EWF18_10335	COG3645	SOS response
EWF18_10335	COG3646	Phage regulatory protein
EWF18_10370	COG0582	viral genome integration into host DNA
EWF18_10385	COG5002	protein histidine kinase activity
EWF18_10390	COG0745	RESPONSE REGULATOR receiver
EWF18_10395	COG1187	pseudouridine synthase activity
EWF18_10420	COG0735	belongs to the Fur family
EWF18_10425	COG0494	nUDIX hydrolase
EWF18_10430	COG0667	Aldo Keto reductase
EWF18_10440	COG4221	oxidoreductase activity
EWF18_10455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EWF18_10465	COG0366	Alpha amylase catalytic
EWF18_10470	COG1609	Transcriptional regulator
EWF18_10495	COG2195	Cleaves the N-terminal amino acid of tripeptides
EWF18_10505	COG4129	membrane
EWF18_10515	COG0508	dehydrogenase complex catalyzes the overall conversion of
EWF18_10520	COG0022	dehydrogenase e1 component
EWF18_10525	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EWF18_10530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EWF18_10535	COG0497	DNA recombination
EWF18_10565	COG1302	Protein conserved in bacteria
EWF18_10570	COG0439	Biotin carboxylase
EWF18_10575	COG0511	ligase activity, forming carbon-carbon bonds
EWF18_10585	COG0006	proline dipeptidase activity
EWF18_10600	COG0095	Lipoate-protein ligase
EWF18_10605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EWF18_10650	COG4537	Required for transformation and DNA binding
EWF18_10655	COG1459	type II secretion system
EWF18_10665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EWF18_10670	COG0011	TIGRFAM Protein of
EWF18_10675	COG1940	carbohydrate kinase activity
EWF18_10680	COG4483	Protein conserved in bacteria
EWF18_10690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EWF18_10710	COG0735	belongs to the Fur family
EWF18_10715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EWF18_10720	COG1121	(ABC) transporter
EWF18_10730	COG0513	Belongs to the DEAD box helicase family
EWF18_10740	COG2384	SAM-dependent methyltransferase
EWF18_10745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EWF18_10760	COG0517	IMP dehydrogenase activity
EWF18_10780	COG0295	cytidine deaminase activity
EWF18_10795	COG1702	phosphate starvation-inducible protein PhoH
EWF18_10810	COG1030	water channel activity
EWF18_10820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EWF18_10825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EWF18_10855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EWF18_10875	COG1466	dna polymerase III delta subunit
EWF18_10880	COG2333	competence protein COMEC
EWF18_10880	COG0658	competence protein
EWF18_10885	COG2131	deaminase
EWF18_10895	COG2226	methyltransferase
EWF18_10900	COG0799	negative regulation of ribosome biogenesis
EWF18_10905	COG1713	HD superfamily hydrolase involved in NAD metabolism
EWF18_10915	COG1534	Rna-binding protein
EWF18_10925	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EWF18_10930	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EWF18_10965	COG0439	Biotin carboxylase
EWF18_10970	COG0511	ligase activity, forming carbon-carbon bonds
EWF18_10975	COG1984	allophanate hydrolase subunit 2
EWF18_10980	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EWF18_11030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EWF18_11045	COG1104	cysteine desulfurase activity
EWF18_11050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EWF18_11065	COG1959	2 iron, 2 sulfur cluster binding
EWF18_11070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EWF18_11075	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EWF18_11120	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EWF18_11120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EWF18_11125	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EWF18_11125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EWF18_11130	COG1862	Preprotein translocase
EWF18_11170	COG2868	ribosomal protein
EWF18_11225	COG0285	dihydrofolate synthase activity
EWF18_11235	COG2818	Glycosylase
EWF18_11255	COG0113	porphobilinogen synthase activity
EWF18_11270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EWF18_11305	COG4112	unkown
EWF18_11330	COG0833	amino acid
EWF18_11345	COG1484	DNA-dependent DNA replication
EWF18_11370	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EWF18_11375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EWF18_11375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EWF18_11385	COG5002	protein histidine kinase activity
EWF18_11390	COG0745	RESPONSE REGULATOR receiver
EWF18_11405	COG0372	Belongs to the citrate synthase family
EWF18_11410	COG1113	amino acid transport
EWF18_11440	COG0281	malic enzyme
EWF18_11450	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EWF18_11460	COG4109	DRTGG domain
EWF18_11500	COG0827	DNA restriction-modification system
EWF18_11510	COG0730	response to heat
EWF18_11520	COG1104	cysteine desulfurase activity
EWF18_11535	COG1956	GAF domain-containing protein
EWF18_11555	COG0584	glycerophosphoryl diester phosphodiesterase
EWF18_11560	COG1764	response to oxidative stress
EWF18_11565	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EWF18_11570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EWF18_11590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EWF18_11590	COG1263	PTS System
EWF18_11595	COG0204	Acyl-transferase
EWF18_11600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EWF18_11630	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EWF18_11635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EWF18_11640	COG0454	-acetyltransferase
EWF18_11660	COG1605	Chorismate mutase
EWF18_11660	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EWF18_11690	COG1674	ftsk spoiiie
EWF18_11695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EWF18_11705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EWF18_11710	COG1363	Peptidase, m42
EWF18_11720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EWF18_11730	COG0510	thiamine kinase activity
EWF18_11750	COG1187	pseudouridine synthase activity
EWF18_11755	COG2244	polysaccharide biosynthetic process
EWF18_11760	COG2081	HI0933 family
EWF18_11780	COG2814	Major facilitator Superfamily
EWF18_11785	COG1242	4 iron, 4 sulfur cluster binding
EWF18_11790	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EWF18_11795	COG1846	Transcriptional regulator
EWF18_11805	COG2267	carboxylic ester hydrolase activity
EWF18_11815	COG0506	proline dehydrogenase activity
EWF18_11835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EWF18_11835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EWF18_11865	COG5632	N-Acetylmuramoyl-L-alanine amidase
EWF18_11865	COG4193	domain, Protein
EWF18_11865	COG3266	domain, Protein
EWF18_11895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EWF18_11905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EWF18_11910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EWF18_11915	COG0656	L-ascorbic acid biosynthetic process
EWF18_11935	COG1506	peptidase
EWF18_12190	COG1131	(ABC) transporter
EWF18_12195	COG0537	adenosine 5'-monophosphoramidase activity
EWF18_12230	COG0420	3'-5' exonuclease activity
EWF18_12260	COG2197	response regulator
EWF18_12265	COG4585	Histidine kinase
EWF18_12265	COG2203	Gaf domain
EWF18_12270	COG0564	pseudouridine synthase activity
EWF18_12310	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EWF18_12315	COG1126	abc transporter atp-binding protein
EWF18_12320	COG0765	amino acid transport
EWF18_12485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EWF18_12490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EWF18_12500	COG4129	membrane
EWF18_12525	COG1988	membrane-bound metal-dependent
EWF18_12540	COG1134	teichoic acid transport
EWF18_12540	COG1388	LysM domain
EWF18_12560	COG3328	transposase activity
EWF18_12575	COG0535	radical SAM domain protein
EWF18_12580	COG1607	acyl-coa hydrolase
EWF18_12585	COG2309	aminopeptidase activity
EWF18_12725	COG4851	CamS sex pheromone cAM373 precursor
EWF18_12735	COG0210	DNA helicase
EWF18_12740	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EWF18_12745	COG4496	protein, YerC YecD
EWF18_12785	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EWF18_12795	COG0077	Prephenate dehydratase
EWF18_12805	COG0471	metal ion transport
EWF18_12815	COG1335	isochorismatase
EWF18_12830	COG1012	belongs to the aldehyde dehydrogenase family
EWF18_12845	COG4974	Belongs to the 'phage' integrase family
EWF18_12920	COG1131	(ABC) transporter
EWF18_12935	COG1725	Transcriptional regulator
EWF18_12965	COG3568	Endonuclease Exonuclease Phosphatase
EWF18_13090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EWF18_13095	COG1621	beta-fructofuranosidase activity
EWF18_13100	COG1609	Transcriptional regulator
EWF18_13105	COG0004	ammonium transporteR
EWF18_13110	COG0425	Belongs to the sulfur carrier protein TusA family
EWF18_13115	COG2391	methyltransferase activity
EWF18_13125	COG0488	(ABC) transporter
EWF18_13135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EWF18_13145	COG0456	acetyltransferase
EWF18_13150	COG1214	PFAM Peptidase M22, glycoprotease
EWF18_13155	COG0802	atpase or kinase
EWF18_13170	COG0028	Belongs to the TPP enzyme family
EWF18_13245	COG2183	response to ionizing radiation
EWF18_13250	COG1191	sigma factor activity
EWF18_13260	COG1366	Belongs to the anti-sigma-factor antagonist family
EWF18_13265	COG2208	phosphoserine phosphatase activity
EWF18_13300	COG3428	Bacterial PH domain
EWF18_13330	COG2205	protein histidine kinase activity
EWF18_13335	COG0745	RESPONSE REGULATOR receiver
EWF18_13345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EWF18_13355	COG0772	Belongs to the SEDS family
EWF18_13370	COG1937	Protein conserved in bacteria
EWF18_13380	COG1418	mRNA catabolic process
EWF18_13420	COG0629	single-stranded DNA binding
EWF18_13495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EWF18_13520	COG0009	L-threonylcarbamoyladenylate synthase
EWF18_13525	COG2890	protein-(glutamine-N5) methyltransferase activity
EWF18_13550	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EWF18_13590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EWF18_13640	COG0813	purine-nucleoside phosphorylase activity
EWF18_13645	COG0783	Belongs to the Dps family
EWF18_13665	COG1482	cell wall glycoprotein biosynthetic process
EWF18_13670	COG0702	epimerase
EWF18_13675	COG0640	Transcriptional regulator
EWF18_13710	COG0561	phosphatase activity
EWF18_13715	COG1119	ATPase activity
EWF18_13730	COG3711	transcriptional antiterminator
EWF18_13760	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EWF18_13820	COG0489	protein tyrosine kinase activity
EWF18_13825	COG2814	Major facilitator Superfamily
EWF18_13850	COG1988	membrane-bound metal-dependent
EWF18_13865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EWF18_13870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EWF18_13885	COG3457	Alanine racemase
EWF18_13895	COG2814	Major facilitator Superfamily
EWF18_13920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EWF18_13930	COG2130	NADP-dependent
EWF18_13975	COG1349	DNA-binding transcription factor activity
EWF18_13980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EWF18_14000	COG0656	L-ascorbic acid biosynthetic process
EWF18_14005	COG0789	Transcriptional regulator
EWF18_14015	COG5492	domain, Protein
EWF18_14035	COG3527	Alpha-acetolactate decarboxylase
EWF18_14040	COG0028	Belongs to the TPP enzyme family
EWF18_14115	COG0201	protein transport
EWF18_14230	COG2252	PERMEase
EWF18_14275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EWF18_14335	COG1763	Mo-molybdopterin cofactor biosynthetic process
EWF18_14355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EWF18_14360	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EWF18_14365	COG4149	molybdate abc transporter
EWF18_14385	COG1268	BioY protein
EWF18_14400	COG1960	acyl-CoA dehydrogenase activity
EWF18_14405	COG4413	Urea transporter
EWF18_14480	COG1757	Na H antiporter
EWF18_14535	COG1316	TRANSCRIPTIONal
EWF18_14565	COG1113	amino acid transport
EWF18_14585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EWF18_14590	COG0385	Bile acid
EWF18_14600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EWF18_14600	COG1263	PTS System
EWF18_14605	COG1737	Transcriptional regulator
EWF18_14625	COG1028	Short-chain dehydrogenase reductase Sdr
EWF18_14630	COG1473	amidohydrolase
EWF18_14645	COG0583	DNA-binding transcription factor activity
EWF18_14670	COG2258	MOSC domain
EWF18_14695	COG4152	abc transporter atp-binding protein
EWF18_14700	COG3152	Membrane
EWF18_14725	COG0598	Magnesium transport protein CorA
EWF18_14740	COG0657	acetylesterase activity
EWF18_14755	COG1566	PFAM secretion protein HlyD family protein
EWF18_14765	COG2814	Major facilitator Superfamily