locus-tag	class	description
EQW00_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EQW00_00010	COG0592	DNA-directed DNA polymerase activity
EQW00_00015	COG2501	S4 domain
EQW00_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EQW00_00025	COG0187	DNA topoisomerase II activity
EQW00_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EQW00_00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EQW00_00040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EQW00_00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EQW00_00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EQW00_00075	COG0359	binds to the 23S rRNA
EQW00_00080	COG0305	Participates in initiation and elongation during chromosome replication
EQW00_00085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EQW00_00105	COG0745	RESPONSE REGULATOR receiver
EQW00_00110	COG5002	protein histidine kinase activity
EQW00_00115	COG4863	YycH protein
EQW00_00125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EQW00_00130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EQW00_00150	COG1131	(ABC) transporter
EQW00_00240	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EQW00_00245	COG0732	type I restriction modification DNA specificity domain
EQW00_00250	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EQW00_00345	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EQW00_00360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EQW00_00395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EQW00_00420	COG0640	Transcriptional regulator
EQW00_00430	COG2217	Heavy metal translocating P-type atpase
EQW00_00455	COG3316	Transposase and inactivated derivatives
EQW00_00460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EQW00_00495	COG3316	Transposase and inactivated derivatives
EQW00_00530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EQW00_00555	COG3316	Transposase and inactivated derivatives
EQW00_00570	COG2801	Transposase and inactivated derivatives
EQW00_00575	COG0549	Belongs to the carbamate kinase family
EQW00_00580	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EQW00_00585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EQW00_00595	COG2235	arginine
EQW00_00630	COG3316	Transposase and inactivated derivatives
EQW00_00645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EQW00_00655	COG1131	(ABC) transporter
EQW00_00670	COG0745	RESPONSE REGULATOR receiver
EQW00_00675	COG5002	protein histidine kinase activity
EQW00_00700	COG2217	Heavy metal translocating P-type atpase
EQW00_00705	COG2132	Multicopper oxidase
EQW00_00710	COG1388	LysM domain
EQW00_00715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EQW00_00720	COG2210	Belongs to the sulfur carrier protein TusA family
EQW00_00725	COG1937	Protein conserved in bacteria
EQW00_00730	COG0730	response to heat
EQW00_00735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EQW00_00740	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EQW00_00760	COG0640	Transcriptional regulator
EQW00_00765	COG0701	Predicted permease
EQW00_00790	COG0668	transmembrane transport
EQW00_00795	COG0561	phosphatase activity
EQW00_00835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EQW00_00840	COG0579	oxidoreductase
EQW00_00855	COG1028	Short-chain dehydrogenase reductase Sdr
EQW00_00865	COG1755	Isoprenylcysteine carboxyl methyltransferase
EQW00_00875	COG4753	response regulator
EQW00_00875	COG2207	Transcriptional regulator
EQW00_00880	COG2972	Histidine kinase
EQW00_00920	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EQW00_00920	COG3583	domain protein
EQW00_00920	COG4932	domain protein
EQW00_00935	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EQW00_00940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EQW00_00945	COG0156	8-amino-7-oxononanoate synthase activity
EQW00_00950	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
EQW00_00975	COG0523	cobalamin synthesis protein
EQW00_01000	COG3976	FMN-binding domain protein
EQW00_01000	COG1053	succinate dehydrogenase
EQW00_01000	COG0431	NADPH-dependent FMN reductase
EQW00_01010	COG1028	Short-chain dehydrogenase reductase Sdr
EQW00_01015	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EQW00_01050	COG0601	transmembrane transport
EQW00_01060	COG0444	Belongs to the ABC transporter superfamily
EQW00_01065	COG1124	(ABC) transporter
EQW00_01075	COG1882	Formate acetyltransferase
EQW00_01080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EQW00_01085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EQW00_01090	COG1114	Component of the transport system for branched-chain amino acids
EQW00_01095	COG1309	transcriptional regulator
EQW00_01100	COG3246	L-lysine catabolic process to acetate
EQW00_01105	COG1250	3-hydroxyacyl-CoA dehydrogenase
EQW00_01140	COG1288	antiporter activity
EQW00_01145	COG0549	Belongs to the carbamate kinase family
EQW00_01150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EQW00_01160	COG0346	lactoylglutathione lyase activity
EQW00_01165	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EQW00_01170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EQW00_01180	COG2376	Dihydroxyacetone kinase
EQW00_01185	COG1461	Dihydroxyacetone kinase
EQW00_01190	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
EQW00_01205	COG2814	Major facilitator Superfamily
EQW00_01240	COG2814	Major facilitator Superfamily
EQW00_01255	COG2962	Rard protein
EQW00_01260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EQW00_01265	COG0471	metal ion transport
EQW00_01270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EQW00_01275	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EQW00_01280	COG0022	dehydrogenase e1 component
EQW00_01285	COG0508	dehydrogenase complex catalyzes the overall conversion of
EQW00_01305	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EQW00_01315	COG3386	PFAM SMP-30 Gluconolaconase
EQW00_01320	COG2353	YceI-like domain
EQW00_01330	COG0579	oxidoreductase
EQW00_01355	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EQW00_01360	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EQW00_01365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EQW00_01370	COG0131	Imidazoleglycerol-phosphate dehydratase
EQW00_01375	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EQW00_01380	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EQW00_01385	COG0107	imidazoleglycerol-phosphate synthase activity
EQW00_01390	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EQW00_01390	COG0140	phosphoribosyl-ATP diphosphatase activity
EQW00_01395	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EQW00_01425	COG2814	Major facilitator Superfamily
EQW00_01430	COG0737	Belongs to the 5'-nucleotidase family
EQW00_01445	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EQW00_01450	COG3639	organic phosphonate transmembrane transporter activity
EQW00_01470	COG0201	protein transport
EQW00_01480	COG1073	alpha beta
EQW00_01490	COG0653	protein targeting
EQW00_01495	COG0438	transferase activity, transferring glycosyl groups
EQW00_01520	COG2814	Major facilitator Superfamily
EQW00_01540	COG1764	response to oxidative stress
EQW00_01550	COG1705	Flagellar rod assembly protein muramidase FlgJ
EQW00_01550	COG3942	CHAP domain
EQW00_01560	COG1482	cell wall glycoprotein biosynthetic process
EQW00_01565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EQW00_01565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EQW00_01565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EQW00_01570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EQW00_01570	COG3711	transcriptional antiterminator
EQW00_01605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EQW00_01610	COG3227	Zinc metalloprotease (Elastase)
EQW00_01615	COG1438	arginine binding
EQW00_01620	COG2235	arginine
EQW00_01625	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EQW00_01635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EQW00_01645	COG2843	Capsule synthesis protein
EQW00_01655	COG3961	Belongs to the TPP enzyme family
EQW00_01665	COG1943	Transposase
EQW00_01695	COG4195	phage-related replication protein
EQW00_01705	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EQW00_01710	COG0702	epimerase
EQW00_01715	COG1785	Belongs to the alkaline phosphatase family
EQW00_01730	COG2205	protein histidine kinase activity
EQW00_01735	COG1136	(ABC) transporter
EQW00_01750	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EQW00_01775	COG1846	Transcriptional regulator
EQW00_01785	COG0386	Belongs to the glutathione peroxidase family
EQW00_01795	COG0175	sulfate reduction
EQW00_01800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EQW00_01805	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EQW00_01820	COG0730	response to heat
EQW00_01825	COG2046	Belongs to the sulfate adenylyltransferase family
EQW00_01830	COG0529	Catalyzes the synthesis of activated sulfate
EQW00_01840	COG1328	CTP reductase activity
EQW00_01845	COG0602	queuosine metabolic process
EQW00_01850	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EQW00_01865	COG1510	regulation of RNA biosynthetic process
EQW00_01875	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EQW00_01880	COG1473	amidohydrolase
EQW00_01895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EQW00_01900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EQW00_01900	COG0574	Belongs to the PEP-utilizing enzyme family
EQW00_01905	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EQW00_01910	COG0579	oxidoreductase
EQW00_01920	COG3588	fructose-bisphosphate aldolase
EQW00_01930	COG0446	pyridine nucleotide-disulphide oxidoreductase
EQW00_01965	COG0531	amino acid
EQW00_01970	COG0583	DNA-binding transcription factor activity
EQW00_01975	COG0039	L-malate dehydrogenase activity
EQW00_01980	COG0028	Belongs to the TPP enzyme family
EQW00_01985	COG3527	Alpha-acetolactate decarboxylase
EQW00_01995	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EQW00_02000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EQW00_02005	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EQW00_02020	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EQW00_02030	COG0167	dihydroorotate dehydrogenase activity
EQW00_02040	COG1113	amino acid transport
EQW00_02060	COG0741	lytic transglycosylase activity
EQW00_02080	COG0436	Aminotransferase
EQW00_02090	COG2608	mercury ion transmembrane transporter activity
EQW00_02095	COG2217	Heavy metal translocating P-type atpase
EQW00_02105	COG1028	Short-chain dehydrogenase reductase Sdr
EQW00_02110	COG1012	belongs to the aldehyde dehydrogenase family
EQW00_02135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EQW00_02140	COG3425	synthase
EQW00_02160	COG0583	DNA-binding transcription factor activity
EQW00_02165	COG1380	Effector of murein hydrolase LrgA
EQW00_02170	COG1346	cytolysis
EQW00_02175	COG0028	Belongs to the TPP enzyme family
EQW00_02195	COG1063	alcohol dehydrogenase
EQW00_02205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EQW00_02220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EQW00_02230	COG2843	Capsule synthesis protein
EQW00_02245	COG4975	Glucose uptake
EQW00_02250	COG1869	D-ribose catabolic process
EQW00_02260	COG1070	Carbohydrate kinase
EQW00_02280	COG1760	l-serine dehydratase
EQW00_02285	COG1760	l-serine dehydratase
EQW00_02300	COG3764	Sortase (surface protein transpeptidase)
EQW00_02310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EQW00_02315	COG0778	Nitroreductase
EQW00_02325	COG1012	belongs to the aldehyde dehydrogenase family
EQW00_02335	COG2514	catechol 2,3-dioxygenase activity
EQW00_02350	COG1012	belongs to the aldehyde dehydrogenase family
EQW00_02355	COG3949	Membrane
EQW00_02370	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
EQW00_02375	COG0586	Pfam SNARE associated Golgi protein
EQW00_02380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EQW00_02385	COG2022	thiamine diphosphate biosynthetic process
EQW00_02395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EQW00_02405	COG2271	Major facilitator Superfamily
EQW00_02420	COG4876	unkown
EQW00_02425	COG2357	RelA SpoT domain protein
EQW00_02445	COG0789	Transcriptional regulator
EQW00_02450	COG2271	Major facilitator Superfamily
EQW00_02455	COG1802	Transcriptional regulator
EQW00_02465	COG2610	gluconate transmembrane transporter activity
EQW00_02470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EQW00_02475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EQW00_02480	COG0438	transferase activity, transferring glycosyl groups
EQW00_02500	COG4221	oxidoreductase activity
EQW00_02505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EQW00_02510	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EQW00_02520	COG1028	Short-chain dehydrogenase reductase Sdr
EQW00_02530	COG1363	Peptidase, m42
EQW00_02540	COG0069	glutamate synthase activity
EQW00_02560	COG4619	ABC transporter
EQW00_02565	COG0390	transport system, permease component
EQW00_02570	COG2814	Major facilitator Superfamily
EQW00_02575	COG2272	Belongs to the type-B carboxylesterase lipase family
EQW00_02580	COG0531	amino acid
EQW00_02590	COG1063	alcohol dehydrogenase
EQW00_02610	COG1174	glycine betaine transport
EQW00_02615	COG1346	cytolysis
EQW00_02620	COG1380	Effector of murein hydrolase LrgA
EQW00_02625	COG3279	Response regulator of the LytR AlgR family
EQW00_02630	COG3275	phosphorelay sensor kinase activity
EQW00_02640	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EQW00_02645	COG0706	membrane insertase activity
EQW00_02655	COG0531	amino acid
EQW00_02660	COG1113	amino acid transport
EQW00_02685	COG1929	Belongs to the glycerate kinase type-1 family
EQW00_02700	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EQW00_02705	COG0588	phosphoglycerate mutase activity
EQW00_02715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EQW00_02720	COG0765	amino acid transport
EQW00_02725	COG1126	abc transporter atp-binding protein
EQW00_02730	COG2348	transferase activity, transferring amino-acyl groups
EQW00_02750	COG2116	formate transmembrane transporter activity
EQW00_02755	COG0454	-acetyltransferase
EQW00_02760	COG0747	negative chemotaxis
EQW00_02775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EQW00_02780	COG2146	nitrite reductase [NAD(P)H] activity
EQW00_02790	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EQW00_02795	COG1140	nitrate reductase beta subunit
EQW00_02805	COG2181	nitrate reductase activity
EQW00_02815	COG4585	Histidine kinase
EQW00_02820	COG2197	response regulator
EQW00_02825	COG2223	nitrite transmembrane transporter activity
EQW00_02830	COG1846	Transcriptional regulator
EQW00_02835	COG0778	Nitroreductase
EQW00_02855	COG3871	stress protein (general stress protein 26)
EQW00_02870	COG1263	PTS System
EQW00_02870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EQW00_02905	COG0604	alcohol dehydrogenase
EQW00_02910	COG0456	acetyltransferase
EQW00_02915	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EQW00_02915	COG0463	Glycosyl transferase, family 2
EQW00_02925	COG0463	Glycosyl transferase, family 2
EQW00_02925	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EQW00_02930	COG1620	l-lactate permease
EQW00_02935	COG0438	transferase activity, transferring glycosyl groups
EQW00_02940	COG0579	oxidoreductase
EQW00_02945	COG5002	protein histidine kinase activity
EQW00_02945	COG3850	Histidine kinase
EQW00_02950	COG0745	RESPONSE REGULATOR receiver
EQW00_02955	COG0577	efflux transmembrane transporter activity
EQW00_02960	COG1136	(ABC) transporter
EQW00_02975	COG4640	response to antibiotic
EQW00_02980	COG2814	Major facilitator Superfamily
EQW00_02990	COG1566	PFAM secretion protein HlyD family protein
EQW00_02995	COG2814	Major facilitator Superfamily
EQW00_03010	COG0657	acetylesterase activity
EQW00_03025	COG0598	Magnesium transport protein CorA
EQW00_03030	COG1304	FMN binding
EQW00_03035	COG0786	glutamate:sodium symporter activity
EQW00_03055	COG2094	Belongs to the DNA glycosylase MPG family
EQW00_03080	COG1069	ribulokinase activity
EQW00_03085	COG2017	converts alpha-aldose to the beta-anomer
EQW00_03090	COG2258	MOSC domain
EQW00_03095	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EQW00_03110	COG1266	CAAX protease self-immunity
EQW00_03115	COG0010	Belongs to the arginase family
EQW00_03120	COG1473	amidohydrolase
EQW00_03125	COG1028	Short-chain dehydrogenase reductase Sdr
EQW00_03130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EQW00_03155	COG1737	Transcriptional regulator
EQW00_03160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EQW00_03160	COG1263	PTS System
EQW00_03170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EQW00_03195	COG1113	amino acid transport
EQW00_03205	COG1263	PTS System
EQW00_03205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EQW00_03210	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EQW00_03225	COG1266	CAAX protease self-immunity
EQW00_03230	COG2378	regulation of single-species biofilm formation
EQW00_03235	COG0483	inositol monophosphate 1-phosphatase activity
EQW00_03270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EQW00_03275	COG2076	Multidrug Resistance protein
EQW00_03280	COG2076	Multidrug Resistance protein
EQW00_03300	COG1757	Na H antiporter
EQW00_03330	COG0829	nickel cation binding
EQW00_03335	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EQW00_03340	COG0830	nickel cation binding
EQW00_03345	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EQW00_03350	COG0804	urea catabolic process
EQW00_03355	COG0832	Belongs to the urease beta subunit family
EQW00_03360	COG0831	urea catabolic process
EQW00_03375	COG1960	acyl-CoA dehydrogenase activity
EQW00_03380	COG1957	nucleoside hydrolase
EQW00_03385	COG1268	BioY protein
EQW00_03395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EQW00_03405	COG0725	ABC transporter, periplasmic molybdate-binding protein
EQW00_03410	COG4149	molybdate abc transporter
EQW00_03415	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EQW00_03420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EQW00_03425	COG0521	Mo-molybdopterin cofactor biosynthetic process
EQW00_03430	COG0315	cyclic pyranopterin monophosphate synthase activity
EQW00_03435	COG0303	'Molybdopterin
EQW00_03445	COG0314	molybdopterin synthase activity
EQW00_03455	COG0746	molybdenum cofactor guanylyltransferase activity
EQW00_03460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EQW00_03495	COG2348	transferase activity, transferring amino-acyl groups
EQW00_03500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EQW00_03520	COG1028	Short-chain dehydrogenase reductase Sdr
EQW00_03525	COG4975	Glucose uptake
EQW00_03530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EQW00_03530	COG0551	DNA topoisomerase type I activity
EQW00_03535	COG2252	PERMEase
EQW00_03550	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EQW00_03555	COG0088	Forms part of the polypeptide exit tunnel
EQW00_03560	COG0089	rRNA binding
EQW00_03565	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EQW00_03570	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EQW00_03575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EQW00_03580	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EQW00_03585	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EQW00_03595	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EQW00_03600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EQW00_03605	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EQW00_03610	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EQW00_03615	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EQW00_03620	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EQW00_03625	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EQW00_03630	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EQW00_03635	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EQW00_03640	COG1841	ribosomal large subunit assembly
EQW00_03645	COG0200	Binds to the 23S rRNA
EQW00_03650	COG0201	protein transport
EQW00_03655	COG0563	adenylate kinase activity
EQW00_03660	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EQW00_03665	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EQW00_03670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EQW00_03675	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EQW00_03680	COG0202	RNA polymerase activity
EQW00_03685	COG0203	ribosomal protein L17
EQW00_03690	COG1122	ATPase activity
EQW00_03695	COG1122	ATPase activity
EQW00_03705	COG0101	tRNA pseudouridine synthase activity
EQW00_03710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EQW00_03715	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EQW00_03720	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EQW00_03725	COG1349	DNA-binding transcription factor activity
EQW00_03730	COG0698	ribose 5-phosphate isomerase
EQW00_03735	COG0698	ribose 5-phosphate isomerase
EQW00_03740	COG1105	Belongs to the carbohydrate kinase PfkB family
EQW00_03745	COG3684	Belongs to the aldolase LacD family
EQW00_03750	COG1447	Phosphotransferase system cellobiose-specific component IIA
EQW00_03755	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EQW00_03755	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EQW00_03760	COG2723	6-phospho-beta-galactosidase activity
EQW00_03770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EQW00_03775	COG2130	NADP-dependent
EQW00_03780	COG0604	alcohol dehydrogenase
EQW00_03795	COG1302	Protein conserved in bacteria
EQW00_03800	COG4264	IucA IucC family
EQW00_03805	COG2814	Major facilitator Superfamily
EQW00_03810	COG4264	IucA IucC family
EQW00_03815	COG3457	Alanine racemase
EQW00_03820	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EQW00_03825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EQW00_03830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EQW00_03840	COG2329	Antibiotic biosynthesis monooxygenase
EQW00_03850	COG1988	membrane-bound metal-dependent
EQW00_03855	COG4284	Utp--glucose-1-phosphate uridylyltransferase
EQW00_03875	COG2814	Major facilitator Superfamily
EQW00_03880	COG0489	protein tyrosine kinase activity
EQW00_03930	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EQW00_03940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EQW00_03945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EQW00_03950	COG0561	phosphatase activity
EQW00_03970	COG0640	Transcriptional regulator
EQW00_03975	COG0702	epimerase
EQW00_03985	COG1482	cell wall glycoprotein biosynthetic process
EQW00_04010	COG0783	Belongs to the Dps family
EQW00_04020	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EQW00_04025	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EQW00_04030	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EQW00_04040	COG1854	S-ribosylhomocysteine lyase activity
EQW00_04060	COG5146	pantothenate kinase activity
EQW00_04070	COG3343	RNA polymerase activity
EQW00_04075	COG0504	CTP synthase activity
EQW00_04085	COG0191	fructose-bisphosphate aldolase activity
EQW00_04090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EQW00_04095	COG1012	belongs to the aldehyde dehydrogenase family
EQW00_04100	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EQW00_04105	COG0254	rRNA binding
EQW00_04115	COG1435	thymidine kinase activity
EQW00_04120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EQW00_04125	COG2890	protein-(glutamine-N5) methyltransferase activity
EQW00_04135	COG0009	L-threonylcarbamoyladenylate synthase
EQW00_04140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EQW00_04145	COG4475	Protein of unknown function (DUF436)
EQW00_04150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EQW00_04155	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EQW00_04160	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EQW00_04170	COG0356	it plays a direct role in the translocation of protons across the membrane
EQW00_04180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EQW00_04185	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EQW00_04190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EQW00_04195	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EQW00_04200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EQW00_04205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EQW00_04215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EQW00_04220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EQW00_04230	COG0629	single-stranded DNA binding
EQW00_04235	COG1388	LysM domain
EQW00_04240	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EQW00_04250	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EQW00_04255	COG0352	thiamine-phosphate diphosphorylase activity
EQW00_04260	COG0706	membrane insertase activity
EQW00_04265	COG1418	mRNA catabolic process
EQW00_04270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EQW00_04275	COG1937	Protein conserved in bacteria
EQW00_04290	COG0772	Belongs to the SEDS family
EQW00_04295	COG1181	Belongs to the D-alanine--D-alanine ligase family
EQW00_04300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EQW00_04305	COG0513	Belongs to the DEAD box helicase family
EQW00_04315	COG3428	Bacterial PH domain
EQW00_04320	COG3402	PFAM membrane-flanked domain
EQW00_04325	COG0736	holo-[acyl-carrier-protein] synthase activity
EQW00_04330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EQW00_04340	COG2337	Toxic component of a toxin-antitoxin (TA) module
EQW00_04345	COG2208	phosphoserine phosphatase activity
EQW00_04360	COG1191	sigma factor activity
EQW00_04365	COG2183	response to ionizing radiation
EQW00_04370	COG3091	SprT-like family
EQW00_04410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EQW00_04415	COG0066	3-isopropylmalate dehydratase activity
EQW00_04420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EQW00_04425	COG0473	3-isopropylmalate dehydrogenase activity
EQW00_04430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EQW00_04435	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EQW00_04445	COG0028	Belongs to the TPP enzyme family
EQW00_04450	COG0129	dihydroxy-acid dehydratase activity
EQW00_04455	COG0802	atpase or kinase
EQW00_04460	COG1214	PFAM Peptidase M22, glycoprotease
EQW00_04465	COG0456	acetyltransferase
EQW00_04470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EQW00_04475	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EQW00_04480	COG0488	(ABC) transporter
EQW00_04485	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EQW00_04495	COG2391	methyltransferase activity
EQW00_04500	COG0425	Belongs to the sulfur carrier protein TusA family
EQW00_04505	COG0004	ammonium transporteR
EQW00_04510	COG1609	Transcriptional regulator
EQW00_04520	COG1621	beta-fructofuranosidase activity
EQW00_04525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EQW00_04530	COG3279	Response regulator of the LytR AlgR family
EQW00_04535	COG3290	protein histidine kinase activity
EQW00_04570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EQW00_04575	COG0459	protein refolding
EQW00_04595	COG1725	Transcriptional regulator
EQW00_04610	COG1131	(ABC) transporter
EQW00_04660	COG4974	Belongs to the 'phage' integrase family
EQW00_04700	COG2706	6-phosphogluconolactonase activity
EQW00_04705	COG1012	belongs to the aldehyde dehydrogenase family
EQW00_04710	COG1227	inorganic diphosphatase activity
EQW00_04715	COG1335	isochorismatase
EQW00_04725	COG0077	Prephenate dehydratase
EQW00_04735	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EQW00_04740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EQW00_04745	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EQW00_04755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EQW00_04760	COG4496	protein, YerC YecD
EQW00_04765	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EQW00_04770	COG0210	DNA helicase
EQW00_04775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EQW00_04780	COG4851	CamS sex pheromone cAM373 precursor
EQW00_04785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EQW00_04790	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EQW00_04795	COG0154	amidase activity
EQW00_04800	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EQW00_04805	COG1597	lipid kinase activity
EQW00_04810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EQW00_04820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EQW00_04830	COG1528	Iron-storage protein
EQW00_04850	COG4129	membrane
EQW00_04855	COG0024	Methionine aminopeptidase
EQW00_04870	COG4585	Histidine kinase
EQW00_04875	COG2197	response regulator
EQW00_04880	COG1295	ribonuclease BN
EQW00_04890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EQW00_04895	COG4840	Belongs to the UPF0435 family
EQW00_04900	COG2309	aminopeptidase activity
EQW00_04905	COG1607	acyl-coa hydrolase
EQW00_04910	COG0535	radical SAM domain protein
EQW00_04925	COG0693	protein deglycase activity
EQW00_04930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EQW00_04935	COG2137	regulation of response to DNA damage stimulus
EQW00_04945	COG1388	LysM domain
EQW00_04945	COG1134	teichoic acid transport
EQW00_04955	COG1988	membrane-bound metal-dependent
EQW00_04965	COG3557	Belongs to the UPF0374 family
EQW00_04975	COG4129	membrane
EQW00_04980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EQW00_04985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EQW00_04990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EQW00_04995	COG0735	belongs to the Fur family
EQW00_05155	COG0765	amino acid transport
EQW00_05160	COG1126	abc transporter atp-binding protein
EQW00_05165	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EQW00_05190	COG0114	fumarate hydratase activity
EQW00_05195	COG0564	pseudouridine synthase activity
EQW00_05200	COG4585	Histidine kinase
EQW00_05200	COG2203	Gaf domain
EQW00_05205	COG2197	response regulator
EQW00_05215	COG4399	Belongs to the UPF0754 family
EQW00_05220	COG3679	Belongs to the UPF0342 family
EQW00_05225	COG0420	3'-5' exonuclease activity
EQW00_05235	COG3481	metal-dependent phosphohydrolase, HD sub domain
EQW00_05245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EQW00_05260	COG0537	adenosine 5'-monophosphoramidase activity
EQW00_05265	COG1131	(ABC) transporter
EQW00_05270	COG4473	ABC transporter
EQW00_05285	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EQW00_05395	COG0318	PFAM AMP-dependent synthetase and ligase
EQW00_05405	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EQW00_05410	COG0494	nUDIX hydrolase
EQW00_05415	COG1506	peptidase
EQW00_05420	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EQW00_05425	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EQW00_05435	COG0656	L-ascorbic acid biosynthetic process
EQW00_05445	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EQW00_05450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EQW00_05460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EQW00_05490	COG4193	domain, Protein
EQW00_05490	COG5632	N-Acetylmuramoyl-L-alanine amidase
EQW00_05490	COG3266	domain, Protein
EQW00_05500	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EQW00_05500	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EQW00_05510	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EQW00_05510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EQW00_05515	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EQW00_05520	COG0506	proline dehydrogenase activity
EQW00_05525	COG2267	carboxylic ester hydrolase activity
EQW00_05530	COG1846	Transcriptional regulator
EQW00_05535	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EQW00_05540	COG1242	4 iron, 4 sulfur cluster binding
EQW00_05545	COG2814	Major facilitator Superfamily
EQW00_05550	COG0495	leucyl-tRNA aminoacylation
EQW00_05565	COG2081	HI0933 family
EQW00_05570	COG2244	polysaccharide biosynthetic process
EQW00_05575	COG1187	pseudouridine synthase activity
EQW00_05585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EQW00_05590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EQW00_05595	COG0510	thiamine kinase activity
EQW00_05600	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EQW00_05610	COG1363	Peptidase, m42
EQW00_05615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EQW00_05620	COG4848	Belongs to the UPF0354 family
EQW00_05625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EQW00_05630	COG1674	ftsk spoiiie
EQW00_05635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EQW00_05640	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
EQW00_05650	COG1605	Chorismate mutase
EQW00_05650	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EQW00_05655	COG1609	Transcriptional regulator
EQW00_05660	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EQW00_05670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EQW00_05675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EQW00_05680	COG0204	Acyl-transferase
EQW00_05685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EQW00_05685	COG1263	PTS System
EQW00_05695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EQW00_05700	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EQW00_05705	COG1764	response to oxidative stress
EQW00_05710	COG0584	glycerophosphoryl diester phosphodiesterase
EQW00_05715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EQW00_05725	COG1956	GAF domain-containing protein
EQW00_05730	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EQW00_05740	COG0301	tRNA thio-modification
EQW00_05750	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EQW00_05755	COG0827	DNA restriction-modification system
EQW00_05760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EQW00_05765	COG0589	response to stress
EQW00_05770	COG0686	Belongs to the AlaDH PNT family
EQW00_05775	COG0006	proline dipeptidase activity
EQW00_05780	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EQW00_05790	COG4109	DRTGG domain
EQW00_05795	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EQW00_05800	COG0587	DNA-directed DNA polymerase activity
EQW00_05805	COG0281	malic enzyme
EQW00_05810	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EQW00_05815	COG0825	malonyl-CoA metabolic process
EQW00_05820	COG0205	6-phosphofructokinase activity
EQW00_05825	COG0469	pyruvate kinase activity
EQW00_05830	COG1113	amino acid transport
EQW00_05835	COG0372	Belongs to the citrate synthase family
EQW00_05840	COG0538	isocitrate dehydrogenase activity
EQW00_05845	COG0745	RESPONSE REGULATOR receiver
EQW00_05850	COG5002	protein histidine kinase activity
EQW00_05855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EQW00_05855	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EQW00_05860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EQW00_05865	COG0237	dephospho-CoA kinase activity
EQW00_05875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EQW00_05885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EQW00_05890	COG3611	Membrane attachment protein
EQW00_05895	COG1484	DNA-dependent DNA replication
EQW00_05900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EQW00_05905	COG0833	amino acid
EQW00_05910	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EQW00_05915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EQW00_05920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EQW00_05925	COG4112	unkown
EQW00_05935	COG0544	peptidyl-prolyl cis-trans isomerase activity
EQW00_05940	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EQW00_05945	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EQW00_05950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EQW00_05960	COG0181	hydroxymethylbilane synthase activity
EQW00_05970	COG0113	porphobilinogen synthase activity
EQW00_05975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EQW00_05985	COG2818	Glycosylase
EQW00_05990	COG0525	valine-tRNA ligase activity
EQW00_05995	COG0285	dihydrofolate synthase activity
EQW00_06005	COG2003	Belongs to the UPF0758 family
EQW00_06025	COG1792	Involved in formation and maintenance of cell shape
EQW00_06035	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EQW00_06040	COG2868	ribosomal protein
EQW00_06045	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EQW00_06050	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EQW00_06055	COG4492	Belongs to the UPF0735 family
EQW00_06060	COG0632	four-way junction helicase activity
EQW00_06065	COG2255	four-way junction helicase activity
EQW00_06070	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EQW00_06075	COG0343	queuine tRNA-ribosyltransferase activity
EQW00_06080	COG1862	Preprotein translocase
EQW00_06085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EQW00_06085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EQW00_06090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EQW00_06090	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EQW00_06095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EQW00_06105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EQW00_06110	COG1490	D-aminoacyl-tRNA deacylase activity
EQW00_06115	COG0860	N-Acetylmuramoyl-L-alanine amidase
EQW00_06120	COG0124	histidyl-tRNA synthetase
EQW00_06125	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EQW00_06135	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EQW00_06140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EQW00_06145	COG1959	2 iron, 2 sulfur cluster binding
EQW00_06155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EQW00_06160	COG1104	cysteine desulfurase activity
EQW00_06165	COG0482	sulfurtransferase activity
EQW00_06175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EQW00_06180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EQW00_06185	COG4472	Bacterial protein of unknown function (DUF965)
EQW00_06190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EQW00_06195	COG3906	Belongs to the UPF0473 family
EQW00_06215	COG0572	uridine kinase
EQW00_06220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EQW00_06225	COG1943	Transposase
EQW00_06230	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EQW00_06235	COG1984	allophanate hydrolase subunit 2
EQW00_06240	COG0511	ligase activity, forming carbon-carbon bonds
EQW00_06245	COG0439	Biotin carboxylase
EQW00_06250	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EQW00_06255	COG1914	H( )-stimulated, divalent metal cation uptake system
EQW00_06260	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EQW00_06265	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EQW00_06270	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EQW00_06275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EQW00_06280	COG1534	Rna-binding protein
EQW00_06285	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EQW00_06290	COG1713	HD superfamily hydrolase involved in NAD metabolism
EQW00_06295	COG0799	negative regulation of ribosome biogenesis
EQW00_06300	COG2226	methyltransferase
EQW00_06310	COG2131	deaminase
EQW00_06315	COG0658	competence protein
EQW00_06315	COG2333	competence protein COMEC
EQW00_06320	COG1466	dna polymerase III delta subunit
EQW00_06325	COG0268	Binds directly to 16S ribosomal RNA
EQW00_06330	COG0481	GTPase activity
EQW00_06335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EQW00_06340	COG1420	regulation of RNA biosynthetic process
EQW00_06345	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EQW00_06350	COG0443	Heat shock 70 kDa protein
EQW00_06355	COG0484	heat shock protein binding
EQW00_06360	COG2264	protein methyltransferase activity
EQW00_06365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EQW00_06370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EQW00_06380	COG1030	water channel activity
EQW00_06385	COG4864	UPF0365 protein
EQW00_06395	COG1702	phosphate starvation-inducible protein PhoH
EQW00_06400	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EQW00_06405	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EQW00_06410	COG0295	cytidine deaminase activity
EQW00_06415	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EQW00_06420	COG1381	Involved in DNA repair and RecF pathway recombination
EQW00_06425	COG0423	glycine-tRNA ligase activity
EQW00_06430	COG0517	IMP dehydrogenase activity
EQW00_06435	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EQW00_06440	COG0358	DNA primase activity
EQW00_06445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EQW00_06450	COG2384	SAM-dependent methyltransferase
EQW00_06455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EQW00_06460	COG0513	Belongs to the DEAD box helicase family
EQW00_06465	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EQW00_06470	COG1121	(ABC) transporter
EQW00_06475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EQW00_06480	COG0735	belongs to the Fur family
EQW00_06485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EQW00_06500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EQW00_06505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EQW00_06515	COG4483	Protein conserved in bacteria
EQW00_06520	COG1940	carbohydrate kinase activity
EQW00_06525	COG0011	TIGRFAM Protein of
EQW00_06535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EQW00_06540	COG1459	type II secretion system
EQW00_06545	COG4537	Required for transformation and DNA binding
EQW00_06570	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EQW00_06575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EQW00_06580	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EQW00_06585	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EQW00_06595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EQW00_06600	COG0095	Lipoate-protein ligase
EQW00_06615	COG0006	proline dipeptidase activity
EQW00_06620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EQW00_06625	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EQW00_06630	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EQW00_06635	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EQW00_06640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EQW00_06645	COG0511	ligase activity, forming carbon-carbon bonds
EQW00_06650	COG0439	Biotin carboxylase
EQW00_06655	COG1302	Protein conserved in bacteria
EQW00_06660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EQW00_06665	COG1570	exodeoxyribonuclease VII activity
EQW00_06670	COG1722	exodeoxyribonuclease VII activity
EQW00_06680	COG1438	arginine binding
EQW00_06685	COG0497	DNA recombination
EQW00_06690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EQW00_06695	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EQW00_06700	COG0022	dehydrogenase e1 component
EQW00_06705	COG0508	dehydrogenase complex catalyzes the overall conversion of
EQW00_06715	COG4129	membrane
EQW00_06720	COG2195	Cleaves the N-terminal amino acid of tripeptides
EQW00_06725	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EQW00_06730	COG0366	Alpha amylase catalytic
EQW00_06745	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EQW00_06750	COG1234	tRNA 3'-trailer cleavage
EQW00_06755	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EQW00_06760	COG1028	Short-chain dehydrogenase reductase Sdr
EQW00_06765	COG0667	Aldo Keto reductase
EQW00_06770	COG0494	nUDIX hydrolase
EQW00_06775	COG0735	belongs to the Fur family
EQW00_06780	COG4974	Belongs to the 'phage' integrase family
EQW00_06785	COG1547	Domain of unknown function (DUF309)
EQW00_06790	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EQW00_06795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EQW00_06800	COG1187	pseudouridine synthase activity
EQW00_06805	COG0745	RESPONSE REGULATOR receiver
EQW00_06825	COG1141	Ferredoxin
EQW00_06835	COG0514	ATP-dependent DNA helicase (RecQ)
EQW00_06840	COG1388	LysM domain
EQW00_06845	COG0492	ferredoxin-NADP+ reductase activity
EQW00_06850	COG0252	asparaginase activity
EQW00_06855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EQW00_06860	COG0539	negative regulation of cytoplasmic translation
EQW00_06865	COG1160	GTP binding
EQW00_06870	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EQW00_06885	COG2226	methyltransferase
EQW00_06895	COG0105	UTP biosynthetic process
EQW00_06900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EQW00_06905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EQW00_06910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EQW00_06920	COG5582	Belongs to the UPF0302 family
EQW00_06925	COG4347	Protein of unknown function (DUF1405)
EQW00_06930	COG2738	Putative neutral zinc metallopeptidase
EQW00_06935	COG1694	Mazg nucleotide pyrophosphohydrolase
EQW00_06940	COG0438	transferase activity, transferring glycosyl groups
EQW00_06945	COG0617	tRNA 3'-terminal CCA addition
EQW00_06950	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EQW00_06950	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EQW00_06955	COG1199	ATP-dependent helicase activity
EQW00_06955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EQW00_06960	COG0017	Asparaginyl-tRNA synthetase
EQW00_06965	COG3935	DnaD domain protein
EQW00_06970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EQW00_06980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EQW00_06980	COG4499	WXG100 protein secretion system (Wss), protein YukC
EQW00_06985	COG3331	DNA recombination
EQW00_06995	COG4474	Belongs to the UPF0398 family
EQW00_07000	COG3599	regulation of cell shape
EQW00_07010	COG0116	Belongs to the methyltransferase superfamily
EQW00_07020	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EQW00_07025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EQW00_07030	COG4372	Transposase
EQW00_07030	COG1196	nuclear chromosome segregation
EQW00_07030	COG1511	domain protein
EQW00_07040	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EQW00_07050	COG1413	lyase activity
EQW00_07065	COG1136	(ABC) transporter
EQW00_07085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EQW00_07090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EQW00_07095	COG2190	(PTS) system
EQW00_07100	COG4479	Belongs to the UPF0346 family
EQW00_07105	COG0793	Belongs to the peptidase S41A family
EQW00_07120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EQW00_07125	COG0671	phosphoesterase, PA-phosphatase related
EQW00_07130	COG3842	ATPase activity
EQW00_07135	COG4209	transmembrane transport
EQW00_07145	COG0395	ABC-type sugar transport system, permease component
EQW00_07155	COG0534	Mate efflux family protein
EQW00_07160	COG1349	DNA-binding transcription factor activity
EQW00_07170	COG0745	RESPONSE REGULATOR receiver
EQW00_07175	COG5002	protein histidine kinase activity
EQW00_07185	COG0567	Dehydrogenase, E1 component
EQW00_07190	COG0508	dehydrogenase complex catalyzes the overall conversion of
EQW00_07210	COG0714	Associated with various cellular activities
EQW00_07215	COG4548	von Willebrand factor, type A
EQW00_07220	COG1114	Component of the transport system for branched-chain amino acids
EQW00_07225	COG3853	Toxic anion resistance protein (TelA)
EQW00_07235	COG1254	Belongs to the acylphosphatase family
EQW00_07245	COG1278	Cold shock
EQW00_07260	COG1131	(ABC) transporter
EQW00_07280	COG1473	amidohydrolase
EQW00_07285	COG2171	N-acyltransferase activity
EQW00_07290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EQW00_07295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EQW00_07300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EQW00_07305	COG0527	aspartate kinase activity
EQW00_07310	COG0488	(ABC) transporter
EQW00_07315	COG2996	Protein conserved in bacteria
EQW00_07320	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EQW00_07325	COG0573	inorganic phosphate transmembrane transporter activity
EQW00_07330	COG0581	inorganic phosphate transmembrane transporter activity
EQW00_07335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EQW00_07340	COG0704	Plays a role in the regulation of phosphate uptake
EQW00_07380	COG2348	transferase activity, transferring amino-acyl groups
EQW00_07385	COG2348	transferase activity, transferring amino-acyl groups
EQW00_07400	COG0159	tryptophan synthase activity
EQW00_07405	COG0133	tryptophan synthase activity
EQW00_07410	COG0135	phosphoribosylanthranilate isomerase activity
EQW00_07415	COG0134	indole-3-glycerol-phosphate synthase activity
EQW00_07420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EQW00_07425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EQW00_07425	COG0512	Glutamine amidotransferase of anthranilate synthase
EQW00_07430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EQW00_07435	COG0287	Prephenate dehydrogenase
EQW00_07440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EQW00_07445	COG1942	4-Oxalocrotonate Tautomerase
EQW00_07455	COG1316	TRANSCRIPTIONal
EQW00_07460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EQW00_07465	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EQW00_07465	COG0392	lysyltransferase activity
EQW00_07470	COG0628	permease
EQW00_07480	COG1115	amino acid carrier protein
EQW00_07485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EQW00_07490	COG0187	DNA topoisomerase II activity
EQW00_07495	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EQW00_07500	COG4841	protein insertion into membrane
EQW00_07505	COG0824	Thioesterase
EQW00_07510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EQW00_07515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EQW00_07520	COG1970	mechanosensitive ion channel activity
EQW00_07525	COG0419	ATPase involved in DNA repair
EQW00_07530	COG0420	3'-5' exonuclease activity
EQW00_07535	COG4846	Membrane protein involved in cytochrome C biogenesis
EQW00_07545	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EQW00_07550	COG4224	UPF0291 protein
EQW00_07560	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EQW00_07570	COG2340	Cysteine-rich secretory protein family
EQW00_07575	COG0516	GMP reductase activity
EQW00_07580	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EQW00_07590	COG0753	catalase activity
EQW00_07595	COG0833	amino acid
EQW00_07610	COG0083	homoserine kinase activity
EQW00_07615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EQW00_07620	COG0460	homoserine dehydrogenase
EQW00_07625	COG0527	aspartate kinase activity
EQW00_07640	COG1525	nuclease
EQW00_07650	COG2197	response regulator
EQW00_07655	COG4585	Histidine kinase
EQW00_07665	COG1131	(ABC) transporter
EQW00_07670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EQW00_07705	COG0174	glutamine synthetase
EQW00_07710	COG0789	Transcriptional regulator
EQW00_07715	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EQW00_07725	COG0386	Belongs to the glutathione peroxidase family
EQW00_07730	COG1923	regulation of RNA biosynthetic process
EQW00_07735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EQW00_07745	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EQW00_07750	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EQW00_07755	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EQW00_07760	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EQW00_07765	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EQW00_07770	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EQW00_07780	COG4550	Control of competence regulator ComK, YlbF/YmcA
EQW00_07785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EQW00_07795	COG4195	phage-related replication protein
EQW00_07800	COG1013	pyruvate-flavodoxin oxidoreductase activity
EQW00_07805	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EQW00_07805	COG0674	pyruvate-flavodoxin oxidoreductase activity
EQW00_07810	COG1692	metallophosphoesterase
EQW00_07820	COG1418	mRNA catabolic process
EQW00_07825	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EQW00_07835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EQW00_07850	COG0300	oxidoreductase activity
EQW00_07855	COG0612	Peptidase, M16
EQW00_07860	COG0612	Peptidase, M16
EQW00_07865	COG2188	Transcriptional regulator
EQW00_07870	COG1674	ftsk spoiiie
EQW00_07875	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EQW00_07880	COG1185	polyribonucleotide nucleotidyltransferase activity
EQW00_07885	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EQW00_07890	COG0196	riboflavin kinase activity
EQW00_07895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EQW00_07900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EQW00_07905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EQW00_07910	COG1358	cellular component organization or biogenesis
EQW00_07915	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EQW00_07920	COG0195	Participates in both transcription termination and antitermination
EQW00_07925	COG0779	Required for maturation of 30S ribosomal subunits
EQW00_07930	COG2176	DNA-directed DNA polymerase activity
EQW00_07935	COG0442	prolyl-tRNA aminoacylation
EQW00_07945	COG4589	Belongs to the CDS family
EQW00_07950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EQW00_07955	COG0233	cytoplasmic translational termination
EQW00_07960	COG0528	UMP kinase activity
EQW00_07965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EQW00_07970	COG0052	Belongs to the universal ribosomal protein uS2 family
EQW00_07975	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EQW00_07980	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EQW00_07985	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EQW00_07990	COG4974	Belongs to the 'phage' integrase family
EQW00_07995	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EQW00_08000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EQW00_08005	COG0758	DNA mediated transformation
EQW00_08010	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EQW00_08015	COG0045	succinate-CoA ligase (ADP-forming) activity
EQW00_08020	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EQW00_08035	COG4485	Bacterial membrane protein, YfhO
EQW00_08045	COG0335	large ribosomal subunit rRNA binding
EQW00_08050	COG0336	Belongs to the RNA methyltransferase TrmD family
EQW00_08055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EQW00_08060	COG0228	four-way junction DNA binding
EQW00_08065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EQW00_08070	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
EQW00_08075	COG0552	protein localization to endoplasmic reticulum
EQW00_08080	COG1196	nuclear chromosome segregation
EQW00_08085	COG0571	ribonuclease III activity
EQW00_08090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EQW00_08095	COG1028	Short-chain dehydrogenase reductase Sdr
EQW00_08105	COG0416	fatty acid biosynthetic process
EQW00_08110	COG1349	DNA-binding transcription factor activity
EQW00_08115	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EQW00_08120	COG1461	Dihydroxyacetone kinase
EQW00_08125	COG1302	Protein conserved in bacteria
EQW00_08130	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EQW00_08140	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EQW00_08145	COG1162	GTPase activity
EQW00_08155	COG0631	protein serine/threonine phosphatase activity
EQW00_08160	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EQW00_08165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EQW00_08165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EQW00_08170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EQW00_08175	COG0242	peptide deformylase activity
EQW00_08185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EQW00_08190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EQW00_08195	COG1758	RNA polymerase activity
EQW00_08200	COG0194	GDP metabolic process
EQW00_08220	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EQW00_08225	COG0284	orotidine-5'-phosphate decarboxylase activity
EQW00_08230	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EQW00_08235	COG0505	Belongs to the CarA family
EQW00_08240	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EQW00_08245	COG0540	Belongs to the ATCase OTCase family
EQW00_08250	COG2233	PERMEase
EQW00_08255	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EQW00_08260	COG0564	pseudouridine synthase activity
EQW00_08265	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EQW00_08280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EQW00_08285	COG3599	regulation of cell shape
EQW00_08295	COG0762	integral membrane protein
EQW00_08300	COG1799	cell septum assembly
EQW00_08305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EQW00_08315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EQW00_08320	COG0849	cell division
EQW00_08325	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EQW00_08330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EQW00_08335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EQW00_08345	COG4839	cell division protein FtsL
EQW00_08350	COG0275	rRNA processing
EQW00_08355	COG2001	Belongs to the MraZ family
EQW00_08360	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EQW00_08365	COG0454	-acetyltransferase
EQW00_08370	COG1011	Hydrolase
EQW00_08405	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EQW00_08410	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EQW00_08415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EQW00_08420	COG1053	succinate dehydrogenase
EQW00_08425	COG2009	succinate dehydrogenase
EQW00_08435	COG0322	excinuclease ABC activity
EQW00_08440	COG3118	belongs to the thioredoxin family
EQW00_08445	COG1193	negative regulation of DNA recombination
EQW00_08450	COG1796	DNA polymerase
EQW00_08450	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EQW00_08460	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EQW00_08465	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EQW00_08470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EQW00_08470	COG0072	phenylalanine-tRNA ligase activity
EQW00_08475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EQW00_08480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EQW00_08495	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EQW00_08510	COG1323	Belongs to the UPF0348 family
EQW00_08515	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EQW00_08520	COG0742	ribosomal rna small subunit methyltransferase
EQW00_08530	COG4471	UPF0298 protein
EQW00_08540	COG0584	glycerophosphoryl diester phosphodiesterase
EQW00_08545	COG3679	Belongs to the UPF0342 family
EQW00_08550	COG2340	Cysteine-rich secretory protein family
EQW00_08560	COG0109	protoheme IX farnesyltransferase activity
EQW00_08565	COG1612	heme a metabolic process
EQW00_08570	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EQW00_08575	COG0772	Belongs to the SEDS family
EQW00_08580	COG4838	Belongs to the UPF0358 family
EQW00_08585	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EQW00_08590	COG4896	Protein conserved in bacteria
EQW00_08615	COG0483	inositol monophosphate 1-phosphatase activity
EQW00_08620	COG4493	Belongs to the UPF0637 family
EQW00_08625	COG1914	H( )-stimulated, divalent metal cation uptake system
EQW00_08650	COG1176	ABC-type spermidine putrescine transport system, permease component I
EQW00_08655	COG3842	ATPase activity
EQW00_08665	COG4476	Belongs to the UPF0223 family
EQW00_08675	COG0508	dehydrogenase complex catalyzes the overall conversion of
EQW00_08680	COG0022	dehydrogenase e1 component
EQW00_08685	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EQW00_08695	COG0242	peptide deformylase activity
EQW00_08705	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EQW00_08710	COG0569	domain protein
EQW00_08715	COG1294	oxidase, subunit
EQW00_08720	COG1271	oxidase subunit
EQW00_08730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EQW00_08735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EQW00_08745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EQW00_08760	COG4716	Myosin-crossreactive antigen
EQW00_08770	COG4172	Belongs to the ABC transporter superfamily
EQW00_08775	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EQW00_08780	COG0151	Belongs to the GarS family
EQW00_08785	COG0138	bifunctional purine biosynthesis protein purh
EQW00_08790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EQW00_08795	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EQW00_08800	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EQW00_08805	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EQW00_08810	COG0047	phosphoribosylformylglycinamidine synthase activity
EQW00_08815	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EQW00_08820	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EQW00_08825	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EQW00_08830	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EQW00_08835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EQW00_08845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EQW00_08850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EQW00_08855	COG1845	cytochrome c oxidase, subunit III
EQW00_08860	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EQW00_08875	COG1316	TRANSCRIPTIONal
EQW00_08885	COG2153	protein acetylation
EQW00_08900	COG3594	Acyltransferase
EQW00_08905	COG0436	Aminotransferase
EQW00_08910	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EQW00_08920	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EQW00_08925	COG1169	isochorismate synthase
EQW00_08935	COG1575	Belongs to the MenA family. Type 1 subfamily
EQW00_08945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EQW00_08955	COG2314	TM2 domain
EQW00_09030	COG4873	Protein conserved in bacteria
EQW00_09040	COG0737	Belongs to the 5'-nucleotidase family
EQW00_09045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EQW00_09050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EQW00_09055	COG0861	Integral membrane protein TerC family
EQW00_09060	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EQW00_09070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EQW00_09075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EQW00_09080	COG2814	Major facilitator Superfamily
EQW00_09085	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EQW00_09090	COG2382	esterase
EQW00_09095	COG0628	permease
EQW00_09105	COG1943	Transposase
EQW00_09125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EQW00_09125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EQW00_09135	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EQW00_09140	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EQW00_09145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EQW00_09150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EQW00_09180	COG0475	glutathione-regulated potassium exporter activity
EQW00_09180	COG0569	domain protein
EQW00_09185	COG2239	Acts as a magnesium transporter
EQW00_09190	COG0564	pseudouridine synthase activity
EQW00_09195	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EQW00_09200	COG2357	RelA SpoT domain protein
EQW00_09215	COG2346	COG2346, Truncated hemoglobins
EQW00_09225	COG1164	Oligoendopeptidase f
EQW00_09235	COG4862	establishment of competence for transformation
EQW00_09240	COG1393	Belongs to the ArsC family
EQW00_09245	COG0180	Tryptophanyl-tRNA synthetase
EQW00_09250	COG4166	transmembrane transport
EQW00_09255	COG4608	Belongs to the ABC transporter superfamily
EQW00_09260	COG0444	Belongs to the ABC transporter superfamily
EQW00_09265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EQW00_09270	COG0601	transmembrane transport
EQW00_09285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EQW00_09295	COG0542	response to heat
EQW00_09310	COG0561	phosphatase activity
EQW00_09315	COG0446	pyridine nucleotide-disulphide oxidoreductase
EQW00_09325	COG0179	Fumarylacetoacetate (FAA) hydrolase
EQW00_09330	COG1074	ATP-dependent DNA helicase activity
EQW00_09335	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EQW00_09350	COG0398	Pfam SNARE associated Golgi protein
EQW00_09355	COG0166	Belongs to the GPI family
EQW00_09360	COG0137	argininosuccinate synthase activity
EQW00_09365	COG0165	Argininosuccinate lyase
EQW00_09370	COG0584	glycerophosphoryl diester phosphodiesterase
EQW00_09380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EQW00_09390	COG1902	pentaerythritol trinitrate reductase activity
EQW00_09395	COG1098	S1 RNA binding domain
EQW00_09400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EQW00_09410	COG2111	Na H antiporter
EQW00_09410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EQW00_09415	COG2111	Na H antiporter
EQW00_09420	COG1006	Multisubunit Na H antiporter MnhC subunit
EQW00_09425	COG0651	ATP synthesis coupled electron transport
EQW00_09430	COG1863	multisubunit Na H antiporter MnhE subunit
EQW00_09435	COG2212	antiporter activity
EQW00_09440	COG1320	monovalent cation:proton antiporter activity
EQW00_09450	COG2050	protein possibly involved in aromatic compounds catabolism
EQW00_09455	COG2056	Na+-H+ antiporter family
EQW00_09460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EQW00_09470	COG1252	NADH dehydrogenase
EQW00_09475	COG0316	Belongs to the HesB IscA family
EQW00_09480	COG4844	belongs to the
EQW00_09485	COG1252	NADH dehydrogenase
EQW00_09490	COG4837	Protein of unknown function (DUF1462)
EQW00_09495	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EQW00_09500	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EQW00_09505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EQW00_09510	COG1696	Membrane protein involved in D-alanine export
EQW00_09515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EQW00_09525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EQW00_09530	COG0647	UMP catabolic process
EQW00_09535	COG2445	Protein of unknown function DUF86
EQW00_09545	COG4470	Protein conserved in bacteria
EQW00_09550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EQW00_09555	COG0737	Belongs to the 5'-nucleotidase family
EQW00_09560	COG0730	response to heat
EQW00_09565	COG1801	Protein of unknown function DUF72
EQW00_09570	COG1253	flavin adenine dinucleotide binding
EQW00_09585	COG0719	Fe-S assembly protein
EQW00_09590	COG0822	iron-sulfur transferase activity
EQW00_09595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EQW00_09600	COG0719	Fe-S assembly protein
EQW00_09605	COG0396	ATPase activity
EQW00_09615	COG3237	CsbD-like
EQW00_09625	COG1464	Belongs to the NlpA lipoprotein family
EQW00_09630	COG2011	ABC-type metal ion transport system permease component
EQW00_09635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EQW00_09645	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EQW00_09655	COG0509	glycine decarboxylation via glycine cleavage system
EQW00_09660	COG1393	Belongs to the ArsC family
EQW00_09665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EQW00_09675	COG0710	3-dehydroquinate dehydratase activity
EQW00_09680	COG1764	response to oxidative stress
EQW00_09735	COG4195	phage-related replication protein
EQW00_09750	COG1278	Cold shock
EQW00_09790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EQW00_09825	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EQW00_09830	COG0557	exoribonuclease II activity
EQW00_09835	COG1647	Serine aminopeptidase, S33
EQW00_09840	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EQW00_09850	COG0148	phosphopyruvate hydratase activity
EQW00_09855	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EQW00_09860	COG0149	triose-phosphate isomerase activity
EQW00_09865	COG0126	phosphoglycerate kinase activity
EQW00_09870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EQW00_09890	COG1090	epimerase
EQW00_09900	COG0740	serine-type endopeptidase activity
EQW00_09910	COG1481	regulation of sporulation
EQW00_09915	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EQW00_09920	COG1660	Displays ATPase and GTPase activities
EQW00_09925	COG0492	ferredoxin-NADP+ reductase activity
EQW00_09940	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EQW00_09945	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EQW00_09950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EQW00_09955	COG0556	nucleotide-excision repair
EQW00_09975	COG1388	LysM domain
EQW00_09975	COG3942	CHAP domain
EQW00_09985	COG0653	protein targeting
EQW00_09990	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EQW00_09995	COG1040	competence protein
EQW00_10000	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EQW00_10010	COG1739	Uncharacterized protein family UPF0029
EQW00_10015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EQW00_10020	COG2199	diguanylate cyclase activity
EQW00_10035	COG2195	Cleaves the N-terminal amino acid of tripeptides
EQW00_10040	COG1929	Belongs to the glycerate kinase type-1 family
EQW00_10060	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EQW00_10075	COG4604	ABC transporter, ATP-binding protein
EQW00_10080	COG4605	iron ion homeostasis
EQW00_10085	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EQW00_10095	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EQW00_10100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EQW00_10105	COG1780	Probably involved in ribonucleotide reductase function
EQW00_10115	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EQW00_10120	COG3104	oligopeptide transport
EQW00_10125	COG1597	lipid kinase activity
EQW00_10130	COG1012	belongs to the aldehyde dehydrogenase family
EQW00_10130	COG1454	alcohol dehydrogenase
EQW00_10135	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
EQW00_10140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EQW00_10145	COG1174	glycine betaine transport
EQW00_10155	COG0514	ATP-dependent DNA helicase (RecQ)
EQW00_10160	COG0488	(ABC) transporter
EQW00_10175	COG1368	sulfuric ester hydrolase activity
EQW00_10185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EQW00_10200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EQW00_10210	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EQW00_10215	COG0720	synthase
EQW00_10220	COG0602	queuosine metabolic process
EQW00_10245	COG0745	RESPONSE REGULATOR receiver
EQW00_10250	COG5002	protein histidine kinase activity
EQW00_10255	COG0463	Glycosyl transferase, family 2
EQW00_10265	COG0656	L-ascorbic acid biosynthetic process
EQW00_10270	COG1253	flavin adenine dinucleotide binding
EQW00_10275	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EQW00_10280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EQW00_10280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EQW00_10280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EQW00_10285	COG1105	Belongs to the carbohydrate kinase PfkB family
EQW00_10290	COG1349	DNA-binding transcription factor activity
EQW00_10300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EQW00_10330	COG0471	metal ion transport
EQW00_10335	COG0039	L-malate dehydrogenase activity
EQW00_10355	COG1846	Transcriptional regulator
EQW00_10360	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EQW00_10365	COG4988	ABC transporter
EQW00_10370	COG1968	undecaprenyl-diphosphatase activity
EQW00_10385	COG1671	Belongs to the UPF0178 family
EQW00_10390	COG1611	Belongs to the LOG family
EQW00_10415	COG2839	Protein conserved in bacteria
EQW00_10420	COG2814	Major facilitator Superfamily
EQW00_10425	COG0583	DNA-binding transcription factor activity
EQW00_10445	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EQW00_10455	COG0217	transcriptional regulatory protein
EQW00_10475	COG1388	LysM domain
EQW00_10475	COG3942	CHAP domain
EQW00_10480	COG0306	phosphate transporter
EQW00_10485	COG1392	Phosphate transport regulator
EQW00_10490	COG0577	efflux transmembrane transporter activity
EQW00_10495	COG1136	(ABC) transporter
EQW00_10500	COG2205	protein histidine kinase activity
EQW00_10505	COG0745	RESPONSE REGULATOR receiver
EQW00_10525	COG3949	Membrane
EQW00_10535	COG1120	ATPase activity
EQW00_10540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EQW00_10550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EQW00_10555	COG1132	(ABC) transporter
EQW00_10570	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EQW00_10580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EQW00_10585	COG1682	transport, permease protein
EQW00_10590	COG1134	teichoic acid transport
EQW00_10595	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EQW00_10605	COG1321	iron dependent repressor
EQW00_10610	COG1121	(ABC) transporter
EQW00_10615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EQW00_10620	COG0803	Belongs to the bacterial solute-binding protein 9 family
EQW00_10630	COG1320	monovalent cation:proton antiporter activity
EQW00_10635	COG2212	antiporter activity
EQW00_10640	COG1863	multisubunit Na H antiporter MnhE subunit
EQW00_10645	COG0651	ATP synthesis coupled electron transport
EQW00_10650	COG1006	Multisubunit Na H antiporter MnhC subunit
EQW00_10655	COG2111	Na H antiporter
EQW00_10660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EQW00_10660	COG2111	Na H antiporter
EQW00_10700	COG0596	Alpha beta hydrolase
EQW00_10720	COG0546	phosphoglycolate phosphatase activity
EQW00_10725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EQW00_10730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EQW00_10740	COG0789	Transcriptional regulator
EQW00_10745	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EQW00_10750	COG0018	arginyl-trna synthetase
EQW00_10775	COG1064	alcohol dehydrogenase
EQW00_10780	COG3875	lactate racemase activity
EQW00_10785	COG1606	tRNA processing
EQW00_10790	COG1691	(AIR) carboxylase
EQW00_10795	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
EQW00_10805	COG1078	dGTPase activity
EQW00_10815	COG0667	Aldo Keto reductase
EQW00_10825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EQW00_10830	COG4844	belongs to the
EQW00_10850	COG0095	Lipoate-protein ligase
EQW00_10855	COG0280	phosphate acetyltransferase
EQW00_10875	COG0531	amino acid
EQW00_10880	COG2363	Small membrane protein
EQW00_10890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EQW00_10900	COG0351	phosphomethylpyrimidine kinase
EQW00_10920	COG0183	Belongs to the thiolase family
EQW00_10925	COG0318	PFAM AMP-dependent synthetase and ligase
EQW00_10935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EQW00_10940	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EQW00_10945	COG0363	glucosamine-6-phosphate deaminase activity
EQW00_10955	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EQW00_10960	COG1469	GTP cyclohydrolase I activity
EQW00_10970	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EQW00_10975	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EQW00_10980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EQW00_10995	COG0431	NADPH-dependent FMN reductase
EQW00_11000	COG0561	phosphatase activity
EQW00_11015	COG1428	Deoxynucleoside kinase
EQW00_11020	COG1428	Deoxynucleoside kinase
EQW00_11035	COG0546	phosphoglycolate phosphatase activity
EQW00_11040	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EQW00_11045	COG1063	alcohol dehydrogenase
EQW00_11050	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EQW00_11055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EQW00_11060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EQW00_11080	COG1473	amidohydrolase
EQW00_11085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EQW00_11090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EQW00_11100	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EQW00_11110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EQW00_11115	COG0085	RNA polymerase activity
EQW00_11120	COG2813	Specifically methylates the guanine in position
EQW00_11125	COG0222	ribosome binding
EQW00_11130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EQW00_11140	COG0081	regulation of translation
EQW00_11145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EQW00_11150	COG0250	Participates in transcription elongation, termination and antitermination
EQW00_11155	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EQW00_11160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EQW00_11170	COG3688	RNA-binding protein containing a PIN domain
EQW00_11175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EQW00_11180	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
EQW00_11185	COG0215	cysteine-tRNA ligase activity
EQW00_11190	COG1045	serine acetyltransferase
EQW00_11195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EQW00_11200	COG4956	integral membrane protein (PIN domain superfamily)
EQW00_11205	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EQW00_11210	COG0542	response to heat
EQW00_11215	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EQW00_11220	COG3880	PFAM UvrB UvrC protein
EQW00_11225	COG4463	regulation of RNA biosynthetic process
EQW00_11230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EQW00_11240	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EQW00_11245	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EQW00_11250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EQW00_11335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EQW00_11340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EQW00_11345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EQW00_11350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EQW00_11355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EQW00_11360	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EQW00_11365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EQW00_11375	COG0037	tRNA processing
EQW00_11380	COG1098	S1 RNA binding domain
EQW00_11390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EQW00_11395	COG3956	TIGRFAM MazG family protein
EQW00_11400	COG2244	polysaccharide biosynthetic process
EQW00_11405	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EQW00_11410	COG0193	aminoacyl-tRNA hydrolase activity
EQW00_11415	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EQW00_11420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EQW00_11425	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EQW00_11430	COG2088	sporulation resulting in formation of a cellular spore
EQW00_11435	COG0251	oxidation-reduction process
EQW00_11440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EQW00_11445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EQW00_11450	COG4466	Protein conserved in bacteria
EQW00_11455	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EQW00_11460	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EQW00_11465	COG0084	hydrolase, TatD family'
EQW00_11470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EQW00_11470	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EQW00_11475	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EQW00_11480	COG2827	Endonuclease containing a URI domain
EQW00_11485	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EQW00_11490	COG4467	Involved in initiation control of chromosome replication
EQW00_11495	COG1774	PSP1 C-terminal conserved region
EQW00_11500	COG0470	DNA polymerase III
EQW00_11505	COG3870	Protein conserved in bacteria
EQW00_11510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EQW00_11515	COG1982	Orn Lys Arg decarboxylase major
EQW00_11540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EQW00_11545	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EQW00_11550	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EQW00_11570	COG2855	membrane
EQW00_11575	COG0583	DNA-binding transcription factor activity
EQW00_11585	COG0493	'glutamate synthase
EQW00_11590	COG0070	glutamate synthase
EQW00_11590	COG0067	glutamate synthase
EQW00_11590	COG0069	glutamate synthase activity
EQW00_11595	COG0583	DNA-binding transcription factor activity
EQW00_11625	COG0438	transferase activity, transferring glycosyl groups
EQW00_11630	COG3942	CHAP domain
EQW00_11630	COG1388	LysM domain
EQW00_11640	COG2011	ABC-type metal ion transport system permease component
EQW00_11645	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EQW00_11650	COG0626	cystathionine gamma-synthase activity
EQW00_11655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EQW00_11665	COG0733	neurotransmitter:sodium symporter activity
EQW00_11675	COG1647	Serine aminopeptidase, S33
EQW00_11690	COG5609	conserved protein (DUF2294)
EQW00_11700	COG3002	Belongs to the UPF0753 family
EQW00_11705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EQW00_11725	COG0523	cobalamin synthesis protein
EQW00_11780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EQW00_11780	COG0519	Catalyzes the synthesis of GMP from XMP
EQW00_11785	COG0516	GMP reductase activity
EQW00_11785	COG0517	IMP dehydrogenase activity
EQW00_11790	COG2233	PERMEase
EQW00_11795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EQW00_11810	COG5183	chlorophyll binding
EQW00_11820	COG1823	symporter activity
EQW00_11825	COG0778	Nitroreductase
EQW00_11835	COG0450	alkyl hydroperoxide reductase
EQW00_11840	COG3634	alkyl hydroperoxide reductase activity
EQW00_11875	COG1280	lysine exporter protein (LysE YggA)
EQW00_11900	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EQW00_11910	COG0360	Binds together with S18 to 16S ribosomal RNA
EQW00_11925	COG0012	GTP binding
EQW00_11930	COG4481	Protein conserved in bacteria
EQW00_11935	COG0668	transmembrane transport
EQW00_11940	COG1475	DNA binding
EQW00_11950	COG0626	cystathionine gamma-synthase activity
EQW00_11955	COG0626	cystathionine gamma-synthase activity
EQW00_11960	COG0646	methionine synthase
EQW00_11960	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EQW00_11965	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EQW00_11975	COG0183	Belongs to the thiolase family
EQW00_11990	COG1476	TRANSCRIPTIONal
EQW00_12000	COG4555	ABC transporter
EQW00_12020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EQW00_12035	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EQW00_12035	COG3266	domain, Protein
EQW00_12035	COG4932	domain protein
EQW00_12035	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EQW00_12035	COG4932	domain protein
EQW00_12035	COG3266	domain, Protein
EQW00_12060	COG1136	(ABC) transporter
EQW00_12065	COG0577	efflux transmembrane transporter activity
EQW00_12085	COG0577	efflux transmembrane transporter activity
EQW00_12090	COG1136	(ABC) transporter
EQW00_12130	COG1475	DNA binding
EQW00_12135	COG0357	Ribosomal RNA small subunit methyltransferase G
EQW00_12140	COG0445	tRNA wobble uridine modification
EQW00_12145	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EQW00_12150	COG0594	ribonuclease P activity
EQW00_12205	COG0640	Transcriptional regulator
EQW00_12230	COG3316	Transposase and inactivated derivatives
EQW00_12235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EQW00_12250	COG0659	secondary active sulfate transmembrane transporter activity
EQW00_12255	COG0589	response to stress