locus-tag class description LH95_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) LH95_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) LH95_00020 ENOG410848D S4 domain protein YaaA LH95_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LH95_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LH95_00040 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) LH95_00045 ENOG4105C84 Histidine ammonia-lyase LH95_00055 ENOG4108YYC ycei family LH95_00060 ENOG4108UMN azlc family LH95_00070 ENOG4105DWV Homoserine O-trans-acetylase LH95_00075 ENOG4108XMW Membrane LH95_00080 ENOG4105BZR domain protein LH95_00085 ENOG4105K9Q Binds to the 23S rRNA (By similarity) LH95_00090 ENOG4105CDU Replicative dna helicase LH95_00095 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis LH95_00105 ENOG4105WDR LH95_00110 ENOG4108JYZ YitT family LH95_00130 ENOG4105CK6 Two component transcriptional regulator (Winged helix family LH95_00135 ENOG4105BZU Histidine kinase LH95_00150 ENOG4105Q2H domain protein LH95_00160 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein LH95_00175 ENOG4105C3U ABC transporter LH95_00180 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) LH95_00185 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) LH95_00190 ENOG4107QMH DNA methylase LH95_00225 ENOG4105CJ1 ABC, transporter LH95_00240 ENOG4107VDP teichoic acid biosynthesis LH95_00265 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) LH95_00285 ENOG4105C5Y PTS System LH95_00290 ENOG4105CVP deoxyribo-dipyrimidine photolyase LH95_00305 ENOG4105CMT Dihydroxyacetone kinase LH95_00310 ENOG4108UTZ Dihydroxyacetone kinase LH95_00315 ENOG4105VDH Dihydroxyacetone kinase LH95_00335 ENOG4105CH6 catalase LH95_00340 ENOG4108IHU transport system permease protein LH95_00345 ENOG4105DQ5 transport system permease protein LH95_00350 ENOG4108MES Periplasmic binding protein LH95_00360 ENOG4105CIF Ornithine Cyclodeaminase LH95_00365 ENOG4105DJU Siderophore biosynthesis protein LH95_00375 ENOG4105DBM Siderophore biosynthesis protein LH95_00380 ENOG4105DUU IucA IucC family protein LH95_00390 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) LH95_00395 ENOG41067FT ParB-like nuclease domain LH95_00400 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) LH95_00405 ENOG4105EV1 Ribose uptake protein RbsU LH95_00410 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) LH95_00415 ENOG4105DBV ornithine carbamoyltransferase LH95_00420 ENOG4105C5B carbamate kinase LH95_00425 ENOG4105CSX c4-dicarboxylate anaerobic carrier LH95_00430 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) LH95_00480 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) LH95_00485 ENOG4108S01 response regulator LH95_00490 ENOG4105BZU Histidine kinase LH95_00495 ENOG4105KCT ABC transporter LH95_00500 ENOG4105CJ1 ABC, transporter LH95_00515 ENOG4105C5Y PTS System LH95_00520 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate LH95_00545 ENOG410907Z n-acetylmuramoyl-l-alanine amidase LH95_00570 ENOG4105K7K Transcriptional regulator LH95_00580 ENOG4105R3P Inner membrane protein yagU LH95_00600 ENOG4106I9N Immunoglobulin G binding protein A LH95_00605 ENOG4105CTS PTS system mannitol-specific LH95_00610 ENOG4105ETD TRANSCRIPTIONal LH95_00625 ENOG4105IJS Transcriptional regulator LH95_00640 ENOG4105DBV ornithine carbamoyltransferase LH95_00645 ENOG4105CEU Arginine dihydrolase LH95_00665 ENOG4105CCI Myosin-Cross-Reactive Antigen LH95_00670 ENOG4107ZQN disulfide bond LH95_00690 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases LH95_00720 ENOG4105FDP GntR family transcriptional regulator LH95_00730 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) LH95_00745 ENOG410830R acetyltransferase LH95_00755 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) LH95_00775 ENOG4105CS2 ec 3.2.1.21 LH95_00780 ENOG4108S3Y transcriptional regulator LH95_00785 ENOG4105CAY ferredoxin--nadp reductase LH95_00790 ENOG4105K56 Transcriptional regulator LH95_00815 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase LH95_00825 ENOG4108EKI Dehydrogenase LH95_00830 ENOG4107QPK )-transporter LH95_00845 ENOG4108IYU L-aspartate oxidase LH95_00850 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase LH95_00855 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) LH95_00870 ENOG4105ESP cell wall surface anchor family protein LH95_00875 ENOG4105FDP GntR family transcriptional regulator LH95_00880 ENOG4105E70 isomerase LH95_00885 ENOG4105DE4 1-phosphofructokinase LH95_00890 ENOG4105D2M Aldolase LH95_00900 ENOG4108EQA pts system LH95_00905 ENOG4105ETZ PTS System LH95_00910 ENOG4105F3R pts system mannose fructose sorbose family iid LH95_00920 ENOG4105CE4 GlcNAc 6-P deacetylase LH95_00935 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) LH95_00940 ENOG4105DWD nucleoside recognition domain protein LH95_00945 ENOG41069M3 Transcriptional regulator LH95_00950 ENOG4107R7I amino acid LH95_00955 ENOG4105C7B Threonine dehydratase LH95_00970 ENOG4105CPQ Dehydrogenase LH95_00975 ENOG4105DAA L-lactate LH95_00980 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) LH95_00985 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) LH95_01010 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) LH95_01015 ENOG4108RYK Nad-dependent epimerase dehydratase LH95_01020 ENOG4105C2C drug resistance transporter, Bcr CflA LH95_01025 ENOG4105D3W isochorismatase LH95_01055 ENOG4108YYS metal-dependent hydrolase (By similarity) LH95_01060 ENOG4105CH6 catalase LH95_01070 ENOG4108RMU ferritin dps family protein LH95_01080 ENOG4105CHM Aminotransferase LH95_01085 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase LH95_01120 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase LH95_01130 ENOG4105D3W isochorismatase LH95_01150 ENOG4108UZX fmn reductase LH95_01165 ENOG4108YM7 Gcn5-related n-acetyltransferase LH95_01170 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase LH95_01175 ENOG4105J1V Triacylglycerol lipase LH95_01185 ENOG4105DWT malate dehydrogenase (quinone) LH95_01195 ENOG4106YAG Part of the accessory SecA2 SecY2 system specifically required for export of LH95_01200 ENOG4108XJK accessory Sec system protein Asp1 LH95_01205 ENOG41089G2 accessory Sec system protein Asp2 LH95_01220 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) LH95_01230 ENOG4105CHU acetyl-coa acetyltransferase LH95_01240 ENOG4105C1G acyl-Coa dehydrogenase LH95_01245 ENOG4105CEY Amp-dependent synthetase and ligase LH95_01250 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) LH95_01260 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component LH95_01270 ENOG4105E2Y ABC, transporter LH95_01280 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) LH95_01290 ENOG4108RVA ribokinase LH95_01320 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia LH95_01330 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC LH95_01335 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase LH95_01340 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) LH95_01355 ENOG4107QN1 sodium solute LH95_01365 ENOG41090U3 tautomerase LH95_01380 ENOG4105DSE periplasmic solute binding protein LH95_01400 ENOG4108KF8 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) LH95_01405 ENOG4105CXY transporter LH95_01410 ENOG4107VQW regulatoR LH95_01435 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase LH95_01440 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter LH95_01450 ENOG4105DU0 nucleoside hydrolase LH95_01460 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) LH95_01465 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) LH95_01470 ENOG4105D9G High-affinity LH95_01475 ENOG4105DJ2 Major Facilitator Superfamily LH95_01485 ENOG4107T5V SNARE associated Golgi LH95_01495 ENOG4105C94 Transporter LH95_01500 ENOG4105TRT Transcriptional regulator LH95_01505 ENOG4105C26 Dehydrogenase LH95_01510 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) LH95_01515 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase LH95_01520 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) LH95_01530 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) LH95_01535 ENOG4105ECC imidazole-glycerol-phosphate dehydratase LH95_01540 ENOG4105CIH Imidazole acetol-phosphate transaminase LH95_01550 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) LH95_01555 ENOG41071FY Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) LH95_01560 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) LH95_01590 ENOG4105CMT Dihydroxyacetone kinase LH95_01595 ENOG4108UTZ Dihydroxyacetone kinase LH95_01605 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA LH95_01610 ENOG4105C26 Dehydrogenase LH95_01620 ENOG4107SKW Inherit from COG: Alpha beta hydrolase LH95_01630 ENOG4105DM4 PTS System LH95_01640 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase LH95_01650 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) LH95_01670 ENOG4107RRN ABC transporter substrate-binding protein LH95_01695 ENOG4107SJB teichoic acid biosynthesis LH95_01720 ENOG4108RCM Nitroreductase LH95_01745 ENOG4105C19 ABC transporter LH95_01750 ENOG4107RBB ABC transporter, permease LH95_01755 ENOG4105J1V Triacylglycerol lipase LH95_01755 ENOG4105J1V Triacylglycerol lipase LH95_01765 ENOG4105PGM cation diffusion facilitator family transporter LH95_01775 ENOG4108YZ9 Urea amidohydrolase subunit gamma LH95_01780 ENOG4105KI2 Urea amidohydrolase subunit beta LH95_01785 ENOG4105CQM Urea amidohydrolase subunit alpha LH95_01790 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) LH95_01795 ENOG4105EJJ Dehydrogenase LH95_01800 ENOG4107RZX Teichoic acid biosynthesis protein LH95_01805 ENOG4105DHP deoxycytidine triphosphate deaminase LH95_01810 ENOG4105CKI cobalamin synthesis protein LH95_01825 ENOG4105CMU LysR family (Transcriptional regulator LH95_01835 ENOG41067MG lrgb family LH95_01845 ENOG4105DHS permease protein LH95_01850 ENOG4105CM4 permease protein LH95_01855 ENOG4108IPW abc transporter atp-binding protein LH95_01875 ENOG4108TVJ Nitroreductase LH95_01885 ENOG41061JJ Peptidase family M23 LH95_01890 ENOG41068JE domain protein LH95_01900 ENOG4105CSR polyphosphate kinase 2 LH95_01905 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) LH95_01930 ENOG4105CYX Short-chain dehydrogenase reductase Sdr LH95_01950 ENOG4107VHA regulatoR LH95_01960 ENOG4107RA9 decarboxylase LH95_01965 ENOG4105CRQ synthase (Component I) LH95_01970 ENOG4105DDQ anthranilate synthase LH95_01980 ENOG4105DK0 Indole-3-glycerol phosphate synthase LH95_01985 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase LH95_01990 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) LH95_01995 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) LH95_02015 ENOG4105BZ1 (ABC) transporter LH95_02020 ENOG4105BZ1 (ABC) transporter LH95_02030 ENOG4105BZG amino acid carrier protein LH95_02035 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 LH95_02040 ENOG4105CZM Major Facilitator LH95_02045 ENOG4105DJB Major Facilitator Superfamily LH95_02050 ENOG4108Z6X (sortase) family LH95_02055 ENOG4105BZW Glycerate kinase LH95_02060 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) LH95_02070 ENOG4105E90 ABC transporter LH95_02080 ENOG4107RDP Dehydrogenase LH95_02095 ENOG4105F1A Pyruvate formate-lyase LH95_02115 ENOG4105C3U ABC transporter LH95_02120 ENOG4108JQ7 (ABC) transporter LH95_02130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LH95_02145 ENOG4105EJQ L-serine dehydratase LH95_02180 ENOG4107QPK )-transporter LH95_02200 ENOG4108XSB acetyltransferase, (GNAT) family LH95_02215 ENOG4108IFG nitrite reductase, (NAD(P)H) LH95_02220 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit LH95_02225 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) LH95_02235 ENOG4108IUE nitrate reductase beta subunit LH95_02255 ENOG4105BZU Histidine kinase LH95_02260 ENOG4105WH1 Two component transcriptional regulator luxr family LH95_02270 ENOG4105DQQ Major facilitator superfamily MFS_1 LH95_02285 ENOG4105CN9 Peptidase m42 family protein LH95_02300 ENOG4105DJ2 Major Facilitator Superfamily LH95_02350 ENOG4107QNK )-transporter LH95_02375 ENOG4108I69 Glycosyl transferases group 1 LH95_02405 ENOG41080C8 DUF218 domain LH95_02410 ENOG41062A4 Transcriptional regulator LH95_02425 ENOG4105ETU transcriptional activator (TenA LH95_02440 ENOG4105XXY Thioredoxin LH95_02460 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) LH95_02465 ENOG4105CKI cobalamin synthesis protein LH95_02470 ENOG4105D6U Sodium Glutamate Symporter LH95_02500 ENOG4105DFD Na H antiporter LH95_02505 ENOG4108VX5 3-methyladenine DNA glycosylase LH95_02525 ENOG4105RHA ABC transporter, permease LH95_02530 ENOG4105KK4 UPF0060 membrane protein LH95_02535 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) LH95_02540 ENOG4105VZ8 Transcriptional regulator LH95_02545 ENOG4108RPX mosc domain containing protein LH95_02550 ENOG4105E66 phosphoriboisomerase A LH95_02555 ENOG4106E7R Lysostaphin resistance protein A LH95_02560 ENOG41088SP formiminoglutamate hydrolase LH95_02565 ENOG4108KB2 LysR family Transcriptional regulator LH95_02570 ENOG4105DWD nucleoside recognition domain protein LH95_02575 ENOG4105CGP Urocanate hydratase LH95_02580 ENOG4105CI2 imidazolone-5-propionate hydrolase LH95_02585 ENOG4105CHH sulfate transporter LH95_02590 ENOG4105CH2 amidohydrolase LH95_02610 ENOG4105C09 Bile acid LH95_02680 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) LH95_02685 ENOG4108HIZ formate dehydrogenase alpha subunit LH95_02700 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis LH95_02710 ENOG4105C5I Dehydrogenase LH95_02715 ENOG41080TC multidrug resistance protein LH95_02720 ENOG410839T multidrug resistance protein LH95_02735 ENOG4105DFD Na H antiporter LH95_02745 ENOG41068JE domain protein LH95_02765 ENOG4105FDT acyl-CoA dehydrogenase LH95_02775 ENOG4108HUF Transporter LH95_02780 ENOG4107RJ1 sodium solute LH95_02790 ENOG4105JXH GntR family transcriptional regulator LH95_02795 ENOG4105DKQ ROK family LH95_02800 ENOG4107ZYJ bioY protein LH95_02815 ENOG4105CQ4 Transcriptional regulator LH95_02820 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) LH95_02825 ENOG4105CMR udp-glucose 4-epimerase LH95_02830 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase LH95_02835 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein LH95_02840 ENOG4105E0C molybdate abc transporter LH95_02845 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) LH95_02850 ENOG4105D06 uba thif-type nad fad binding protein LH95_02855 ENOG4105EPU Molybdenum cofactor synthesis domain protein LH95_02860 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) LH95_02865 ENOG4105CVM Molybdenum cofactor synthesis domain protein LH95_02875 ENOG4108ZAF Molybdopterin LH95_02885 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) LH95_02890 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) LH95_02915 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) LH95_02960 ENOG4105C7N Xanthine uracil vitamin C permease LH95_02975 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) LH95_02980 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) LH95_02985 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) LH95_02990 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity LH95_02995 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) LH95_03000 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) LH95_03005 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) LH95_03015 ENOG41082SA 50s ribosomal protein l29 LH95_03025 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) LH95_03030 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) LH95_03035 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits LH95_03040 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) LH95_03045 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) LH95_03065 ENOG4105VPB 50S ribosomal protein L30 LH95_03075 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) LH95_03080 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) LH95_03090 ENOG41067V7 50S ribosomal protein L36 LH95_03100 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) LH95_03105 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) LH95_03110 ENOG4108ZT0 50S ribosomal protein l17 LH95_03115 ENOG4108JJB ABC transporter LH95_03120 ENOG4108JJB ABC transporter LH95_03130 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) LH95_03140 ENOG4108UJD 30S ribosomal protein S9 LH95_03145 ENOG4105CB5 ATP-dependent DNA helicase recG LH95_03155 ENOG4105C75 arginyL-tRNA synthetase LH95_03170 ENOG4108W2Y isochorismatase LH95_03180 ENOG4105C5H ABC transporter LH95_03185 ENOG4105DEN Luciferase family LH95_03190 ENOG4105CIS alcohol dehydrogenase LH95_03195 ENOG4105C94 Transporter LH95_03210 ENOG4105VBF alkaline shock protein LH95_03215 ENOG4105F27 Major Facilitator LH95_03225 ENOG4107SFI Major Facilitator superfamily LH95_03235 ENOG4106M28 alanine racemase domain protein LH95_03240 ENOG4108HUF Transporter LH95_03245 ENOG4105DQ5 transport system permease protein LH95_03250 ENOG4108U1V ABC transporter, permease LH95_03255 ENOG4105DWD nucleoside recognition domain protein LH95_03260 ENOG4107DUR UPF0457 protein LH95_03265 ENOG4107K5X Membrane-bound metal-dependent hydrolase LH95_03270 ENOG4108MYC UTP-glucose-1-phosphate uridylyltransferase LH95_03300 ENOG4105D1F ATP-binding protein LH95_03350 ENOG4105CYW agmatinase LH95_03365 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) LH95_03375 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) LH95_03390 ENOG4105JXH GntR family transcriptional regulator LH95_03395 ENOG4105DG6 mannose-6-phosphate isomerase LH95_03415 ENOG4105D3A purine nucleoside phosphorylase DeoD-type LH95_03420 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) LH95_03450 ENOG4105HNY Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) LH95_03475 ENOG4105CXY transporter LH95_03485 ENOG4105D2N Aldolase LH95_03490 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) LH95_03510 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) LH95_03515 ENOG41082DI 50s ribosomal protein l31 LH95_03520 ENOG4107104 thymidine kinase LH95_03525 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) LH95_03530 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) LH95_03535 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) LH95_03540 ENOG4107WAU Protein tyrosine phosphatase LH95_03545 ENOG4108UIC UPF0340 protein LH95_03555 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) LH95_03560 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase LH95_03570 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) LH95_03575 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) LH95_03585 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) LH95_03590 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) LH95_03595 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) LH95_03615 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) LH95_03625 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) LH95_03640 ENOG4105JH5 thiaminase II LH95_03650 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase LH95_03655 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) LH95_03660 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) LH95_03680 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) LH95_03685 ENOG4105VPX protein, conserved in bacteria LH95_03700 ENOG4105C59 p-type ATPase LH95_03715 ENOG4105CPF Cell wall formation (By similarity) LH95_03720 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) LH95_03725 ENOG4105C1J atp-dependent rna helicase LH95_03745 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) LH95_03750 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) LH95_03760 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) LH95_03765 ENOG4107SGM protein serine threonine phosphatase LH95_03770 ENOG4105WN5 stage II sporulation protein LH95_03775 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) LH95_03790 ENOG410906U SprT-like LH95_03820 ENOG4105C7B Threonine dehydratase LH95_03830 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) LH95_03840 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) LH95_03855 ENOG4105C7K acetolactate synthase LH95_03860 ENOG4105C01 Dihydroxy-acid dehydratase LH95_03870 ENOG4105K8N protein family UPF0079, ATPase LH95_03875 ENOG41072GX Peptidase M22 Glycoprotease LH95_03880 ENOG410801F ribosomal-protein-alanine acetyltransferase LH95_03885 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) LH95_03890 ENOG4105C5H ABC transporter LH95_03895 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) LH95_03900 ENOG4105CUC YeeE YedE family protein LH95_03915 ENOG4108WCX response regulator LH95_03940 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase LH95_04000 ENOG4108V4B ThiJ pfpI LH95_04010 ENOG4105D01 (LipO)protein LH95_04015 ENOG4105D01 (LipO)protein LH95_04025 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) LH95_04050 ENOG4105CJ1 ABC, transporter LH95_04060 ENOG4105G3Z GntR family transcriptional regulator LH95_04065 ENOG4105CMG Carbohydrate kinase LH95_04070 ENOG4105C6Z Gluconate LH95_04110 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) LH95_04115 ENOG4105C26 Dehydrogenase LH95_04125 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase LH95_04140 ENOG4105CQC Prephenate dehydratase LH95_04150 ENOG4105DAP Nicotinate phosphoribosyltransferase LH95_04155 ENOG4107RA1 nh(3)-dependent nad( ) synthetase LH95_04160 ENOG4108U5N UPF0316 protein LH95_04170 ENOG4105C83 adenylosuccinate lyase LH95_04175 ENOG4105KGF protein, YerC YecD LH95_04180 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) LH95_04185 ENOG4105C4R Atp-dependent dna helicase LH95_04190 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) LH95_04200 ENOG4105CK7 Sodium proline symporter LH95_04205 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) LH95_04210 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) LH95_04215 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) LH95_04225 ENOG4105CBD Diacylglycerol kinase LH95_04230 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) LH95_04245 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) LH95_04255 ENOG41090A1 ferritin LH95_04270 ENOG4108V3A UPF0421 protein LH95_04275 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) LH95_04290 ENOG4105ENE Histidine kinase LH95_04300 ENOG4108V2W Carbonate dehydratase LH95_04305 ENOG4107U9T Pfam:Ribonuclease_BN LH95_04315 ENOG4107ZCW Low molecular weight phosphotyrosine protein phosphatase LH95_04330 ENOG4108S4H thioesterase Superfamily protein LH95_04345 ENOG4108Z0Z intracellular protease Pfpi family LH95_04360 ENOG410902V Modulates RecA activity (By similarity) LH95_04370 ENOG4105EY8 ABC transporter LH95_04380 ENOG41067AE Membrane-bound metal-dependent hydrolase LH95_04400 ENOG4105CBC glutamate synthase LH95_04405 ENOG4107NBY Membrane LH95_04410 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase LH95_04415 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen LH95_04425 ENOG4105G5W regulator Fur family LH95_04575 ENOG4105CPF Cell wall formation (By similarity) LH95_04580 ENOG4105CPF Cell wall formation (By similarity) LH95_04590 ENOG4105E5Q amino acid AbC transporter LH95_04595 ENOG4105CDA abc transporter atp-binding protein LH95_04600 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) LH95_04610 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) LH95_04625 ENOG4105C9Q fumarate hydratase class II LH95_04635 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) LH95_04640 ENOG4108YBP pseudouridine synthase LH95_04645 ENOG4105BZU Histidine kinase LH95_04650 ENOG4105WH1 Two component transcriptional regulator luxr family LH95_04680 ENOG4108UH6 UPF0754 membrane protein LH95_04685 ENOG4105WZB UPF0342 protein LH95_04690 ENOG4107VRP DNA repair exonuclease LH95_04700 ENOG4105EQI Metal Dependent Phosphohydrolase LH95_04705 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) LH95_04715 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) LH95_04725 ENOG4105K59 histidine triad (HIT) protein LH95_04745 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) LH95_04750 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) LH95_04755 ENOG4105C1Q protoporphyrinogen oxidase LH95_04760 ENOG4105MJ9 esterase LH95_04820 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) LH95_04830 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) LH95_04860 ENOG4105DY8 decarboxylase LH95_04865 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein LH95_04880 ENOG4105CEY Amp-dependent synthetase and ligase LH95_04890 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) LH95_04905 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase LH95_04910 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP LH95_04925 ENOG4106A8V Protein CrcB homolog LH95_04930 ENOG4106A8V Protein CrcB homolog LH95_04940 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) LH95_04965 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis LH95_04980 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) LH95_04985 ENOG4108R6K riboflavin synthase, subunit alpha LH95_04990 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) LH95_04995 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) LH95_05015 ENOG4105E8V Alpha Beta Hydrolase Fold protein LH95_05020 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) LH95_05035 ENOG4105N5T Radical SAM Protein LH95_05040 ENOG410605W Major Facilitator LH95_05045 ENOG4105C8T Leucyl-tRNA synthetase LH95_05050 ENOG41085GJ domain protein LH95_05055 ENOG4105CBX hi0933 family LH95_05075 ENOG4107QSE Dipeptidase LH95_05080 ENOG4105F0I Aminotransferase LH95_05085 ENOG4108V15 phosphotransferase enzyme family LH95_05090 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) LH95_05095 ENOG4105C8F Beta-lactamase domain protein LH95_05115 ENOG4108NKM UPF0354 protein LH95_05120 ENOG4108VDD TRNA binding domain protein LH95_05130 ENOG4105DFU Cell wall formation (By similarity) LH95_05135 ENOG4105MQN general stress protein LH95_05145 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase LH95_05160 ENOG4105F1V Acetoin utilization protein LH95_05170 ENOG4105CKU formyltetrahydrofolate synthetase LH95_05175 ENOG4105BZ4 penicillin-binding protein LH95_05185 ENOG4105C0H protease LH95_05190 ENOG4105F6E Acyl-transferase LH95_05200 ENOG4108JQ1 Dehydrogenase LH95_05205 ENOG4105C5R Aminotransferase LH95_05210 ENOG4108X3M OsmC Ohr family protein LH95_05220 ENOG4105CIF Ornithine Cyclodeaminase LH95_05225 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) LH95_05235 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) LH95_05240 ENOG4105C3J Cysteine desulfurase LH95_05245 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) LH95_05255 ENOG4105D07 Signal peptide peptidase, SppA LH95_05265 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) LH95_05275 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) LH95_05280 ENOG4107YZX Universal stress protein LH95_05285 ENOG4105DCF alanine dehydrogenase LH95_05295 ENOG4105DC7 peptidase M24 LH95_05300 ENOG4105E8R UPF0173 metal-dependent hydrolase LH95_05315 ENOG4105SFS phosphoesterase RecJ domain protein LH95_05320 ENOG4105C0B DNA polymerase III (alpha subunit) LH95_05325 ENOG4105C6K Malic enzyme LH95_05330 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) LH95_05335 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) LH95_05340 ENOG4105CTQ phosphohexokinase LH95_05345 ENOG4105CA9 Pyruvate kinase LH95_05350 ENOG4105BZN citrate synthase LH95_05360 ENOG4105DPZ Two component transcriptional regulator (Winged helix family LH95_05365 ENOG4105BZU Histidine kinase LH95_05370 ENOG4105C2M dna polymerase I LH95_05375 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) LH95_05380 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) LH95_05385 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase LH95_05390 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) LH95_05410 ENOG4108IQI permease LH95_05415 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) LH95_05420 ENOG4105VJV 50s ribosomal protein L35 LH95_05425 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) LH95_05430 ENOG4105U6W MutT NUDIX family protein LH95_05440 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation LH95_05445 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) LH95_05450 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) LH95_05455 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) LH95_05465 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) LH95_05475 ENOG4105D52 delta-aminolevulinic acid dehydratase LH95_05480 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase LH95_05490 ENOG4108R3E Dna-3-methyladenine glycosylase i LH95_05495 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) LH95_05500 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase LH95_05510 ENOG4105W5Q DNA repair protein (RadC LH95_05535 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) LH95_05540 ENOG4105X36 (ribosomal) protein LH95_05555 ENOG41090I5 UPF0735 ACT domain-containing protein LH95_05560 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) LH95_05565 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) LH95_05570 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) LH95_05580 ENOG4105VIE preprotein translocase, subunit YajC LH95_05585 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) LH95_05590 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) LH95_05595 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) LH95_05605 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) LH95_05610 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase LH95_05620 ENOG4105C9M aspartyl-trna synthetase LH95_05625 ENOG4105CUZ uba thif-type nad fad binding protein LH95_05630 ENOG4105D1H recombination factor protein RarA LH95_05650 ENOG4105DEN Luciferase family LH95_05655 ENOG4105C3J Cysteine desulfurase LH95_05660 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) LH95_05670 ENOG4105C7H Helicase, RecD TraA family LH95_05675 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) LH95_05680 ENOG4105VBH UPF0297 protein LH95_05685 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) LH95_05690 ENOG4105VPH UPF0473 protein LH95_05695 ENOG4108VQJ O-methyltransferase LH95_05700 ENOG4105XYU peptidase (U32 family) LH95_05705 ENOG4105CFP Peptidase U32 LH95_05710 ENOG4105DBI uridine monophosphokinase LH95_05720 ENOG4105P4J Allophanate hydrolase, subunit 1 LH95_05730 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein LH95_05735 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase LH95_05740 ENOG4105E7W lamb ycsf family protein LH95_05745 ENOG4105C5A transporter LH95_05755 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) LH95_05760 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase LH95_05765 ENOG4105CQW ribosome biogenesis GTPase YqeH LH95_05770 ENOG4105E2X shikimate dehydrogenase LH95_05775 ENOG410812S Rna-binding protein LH95_05785 ENOG4108WF2 Metal Dependent Phosphohydrolase LH95_05795 ENOG4105DXX methyltransferase LH95_05800 ENOG4105KQC Competence protein LH95_05810 ENOG4108UK2 deaminase LH95_05815 ENOG4108EC8 DNA internalization-related competence protein ComEC LH95_05820 ENOG4105TQK DNA polymerase iii, delta' subunit LH95_05825 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) LH95_05835 ENOG4105CSA Coproporphyrinogen iii oxidase LH95_05840 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) LH95_05855 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) LH95_05860 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) LH95_05865 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) LH95_05870 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) LH95_05885 ENOG4105DI5 UPF0365 protein LH95_05895 ENOG4105C9A Phoh family LH95_05900 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) LH95_05905 ENOG4107YR5 Diacylglycerol kinase LH95_05910 ENOG4105KG3 cytidine deaminase LH95_05920 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) LH95_05925 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) LH95_05935 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) LH95_05940 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) LH95_05945 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LH95_05955 ENOG4105EGD dinuclear metal center protein, YbgI family LH95_05960 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) LH95_05965 ENOG4105C1J atp-dependent rna helicase LH95_05970 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) LH95_05975 ENOG4105FDK ABC transporter LH95_05985 ENOG4105N80 Ferric uptake regulator, Fur family LH95_05990 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) LH95_05995 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) LH95_06000 ENOG4107RF6 penicillin-binding protein LH95_06005 ENOG4105EXS phosphate abc transporter LH95_06010 ENOG4105C8U phosphate abc transporter LH95_06015 ENOG4105E2Z phosphate ABC transporter (Permease LH95_06020 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) LH95_06025 ENOG4108UTW Plays a role in the regulation of phosphate uptake LH95_06030 ENOG4105WDJ 50S ribosomal protein L33 LH95_06035 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase LH95_06040 ENOG4107ZXI Rhomboid family LH95_06060 ENOG4105C5X domain protein LH95_06090 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) LH95_06095 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) LH95_06105 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor LH95_06110 ENOG4105WZW rhodanese family LH95_06115 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) LH95_06130 ENOG4105DC7 peptidase M24 LH95_06135 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) LH95_06145 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase LH95_06150 ENOG4108ZSR alkaline shock protein LH95_06170 ENOG4105CTB Polyprenyl synthetase LH95_06175 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) LH95_06180 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) LH95_06185 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) LH95_06195 ENOG4105CKM Branched-chain carboxylic acid kinase LH95_06210 ENOG4105CPP Dehydrogenase, E1 component LH95_06215 ENOG4105C7S Dehydrogenase LH95_06225 ENOG4108QEG Membrane LH95_06235 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) LH95_06240 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) LH95_06250 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase LH95_06255 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) LH95_06260 ENOG4105II7 pyrroline-5-carboxylate reductase LH95_06270 ENOG4105CPC Aldo Keto reductase LH95_06275 ENOG4108YZ4 nudix hydrolase LH95_06280 ENOG4105I3K Ferric uptake regulator, Fur family LH95_06285 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) LH95_06295 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) LH95_06300 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) LH95_06305 ENOG4105FE9 pseudouridine synthase LH95_06310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family LH95_06315 ENOG4105BZU Histidine kinase LH95_06335 ENOG4105C9U ATP-dependent DNA helicase RecQ LH95_06345 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase LH95_06350 ENOG4105HDK L-asparaginase LH95_06355 ENOG4105CAT Cytidine monophosphate kinase LH95_06360 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) LH95_06375 ENOG4105K70 DNA-binding protein LH95_06385 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) LH95_06390 ENOG4105EAH synthase LH95_06395 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) LH95_06405 ENOG4105D49 3-dehydroquinate synthase LH95_06415 ENOG41068YB TPR repeat-containing protein LH95_06420 ENOG4105QKB UPF0302 protein LH95_06435 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase LH95_06440 ENOG4105CPK Glycosyl transferase (Group 1 LH95_06445 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate LH95_06455 ENOG4105DVT helicase LH95_06460 ENOG4105C5S asparaginyl-tRNA synthetase LH95_06470 ENOG4105CSM endonuclease III LH95_06480 ENOG4105BZ4 penicillin-binding protein LH95_06485 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) LH95_06495 ENOG4108UKS UPF0398 protein LH95_06500 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) LH95_06510 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) LH95_06515 ENOG4105FR1 rard protein LH95_06520 ENOG410890F Dynamin family LH95_06545 ENOG4106QQ5 PBS lyase HEAT domain protein repeat-containing protein LH95_06550 ENOG4108Y6J UPF0403 protein LH95_06560 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) LH95_06570 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) LH95_06580 ENOG4105C5Y PTS System LH95_06600 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) LH95_06605 ENOG410841Q phosphoesterase PA-phosphatase related protein LH95_06615 ENOG4105GR3 Histidine kinase LH95_06645 ENOG4105GMT ATPase associated with various cellular activities aaa_5 LH95_06650 ENOG4107T89 von Willebrand factor, type A LH95_06655 ENOG4105CWM branched-chain amino acid transport system II carrier protein LH95_06660 ENOG4105CDW Resistance protein LH95_06670 ENOG410855V Acylphosphatase LH95_06680 ENOG4105VEQ Cold shock protein LH95_06685 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) LH95_06690 ENOG4108XFP Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) LH95_06695 ENOG4105CH2 amidohydrolase LH95_06700 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) LH95_06705 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) LH95_06710 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) LH95_06715 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) LH95_06720 ENOG4105C5H ABC transporter LH95_06725 ENOG4105QNR S1 RNA binding domain protein LH95_06730 ENOG4105CID antiterminator LH95_06735 ENOG4105VCP PTS System LH95_06740 ENOG4105CK1 PTS System LH95_06745 ENOG4105CS2 ec 3.2.1.21 LH95_06755 ENOG4108YZG isomerase LH95_06760 ENOG4105RSI Galactose-6-phosphate isomerase subunit LacA LH95_06785 ENOG4108RMH femAB family LH95_06790 ENOG4105DER m42 family LH95_06795 ENOG4105EVN Prephenate dehydrogenase LH95_06805 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) LH95_06820 ENOG4108RCF TRANSCRIPTIONal LH95_06825 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) LH95_06845 ENOG4105CID antiterminator LH95_06855 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LH95_06860 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LH95_06865 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) LH95_06880 ENOG4108I0Z Aconitate hydratase LH95_06885 ENOG4105C94 Transporter LH95_06890 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) LH95_06915 ENOG4105VXM UPF0154 protein LH95_06920 ENOG4105CV1 Transketolase (EC 2.2.1.1) LH95_06925 ENOG4105VPS UPF0291 protein LH95_06935 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) LH95_06950 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) LH95_06965 ENOG4108IQI permease LH95_06975 ENOG4105J7I hydrolase LH95_06980 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) LH95_06985 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) LH95_06990 ENOG4105D6E homoserine dehydrogenase LH95_06995 ENOG4105CFH Aspartokinase LH95_07020 ENOG4105WKZ CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) LH95_07040 ENOG4108Z86 Glutamine amidotransferase LH95_07065 ENOG4107Y9E nuclease LH95_07155 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) LH95_07160 ENOG4105C5F glutamine synthetase LH95_07165 ENOG4105KV4 Transcriptional regulator LH95_07170 ENOG4105CXI aluminum resistance protein LH95_07175 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) LH95_07180 ENOG4108V06 Glutathione peroxidase LH95_07185 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) LH95_07190 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) LH95_07195 ENOG4105E8V Alpha Beta Hydrolase Fold protein LH95_07200 ENOG4105C6V Glycerol-3-phosphate dehydrogenase LH95_07220 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator LH95_07225 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) LH95_07230 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) LH95_07245 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) LH95_07255 ENOG4105DQU oxidoreductase, subunit beta LH95_07260 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein LH95_07265 ENOG4105D48 metallophosphoesterase LH95_07290 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) LH95_07295 ENOG4105CEV competence damage-inducible protein LH95_07300 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase LH95_07315 ENOG4105CHR reductase LH95_07330 ENOG4105FDP GntR family transcriptional regulator LH95_07350 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) LH95_07360 ENOG4105DTN riboflavin biosynthesis protein ribF LH95_07365 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) LH95_07370 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) LH95_07395 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) LH95_07435 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) LH95_07440 ENOG4105VHM ribosomal protein LH95_07445 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination LH95_07450 ENOG4105CHV Transcription elongation factor NusA LH95_07455 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) LH95_07465 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) LH95_07475 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) LH95_07480 ENOG4105KNE Phosphatidate cytidylyltransferase LH95_07485 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) LH95_07490 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) LH95_07495 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) LH95_07500 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) LH95_07505 ENOG4105CE9 30S ribosomal protein S2 LH95_07510 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) LH95_07515 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) LH95_07520 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) LH95_07525 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) LH95_07530 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) LH95_07535 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) LH95_07540 ENOG4105C79 DNA protecting protein DprA LH95_07545 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha LH95_07550 ENOG4105CMV Succinyl-CoA synthetase subunit beta LH95_07565 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) LH95_07570 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) LH95_07580 ENOG4105EJV Membrane LH95_07590 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) LH95_07595 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) LH95_07605 ENOG4105K5M 30s ribosomal protein S16 LH95_07615 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) LH95_07620 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) LH95_07625 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) LH95_07635 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) LH95_07640 ENOG4105CHR reductase LH95_07650 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) LH95_07655 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) LH95_07660 ENOG4105CB5 ATP-dependent DNA helicase recG LH95_07665 ENOG4105EJQ L-serine dehydratase LH95_07675 ENOG4105DP4 dak2 domain fusion protein ylov LH95_07680 ENOG4108ZAA Alkaline-shock protein LH95_07685 ENOG4105VB9 50S ribosomal protein l28 LH95_07695 ENOG4105DJV ribulose-phosphate 3-epimerase LH95_07700 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) LH95_07715 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs LH95_07720 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B LH95_07725 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) LH95_07745 ENOG4105C25 Primosomal protein n' LH95_07750 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase LH95_07755 ENOG41067UH Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) LH95_07760 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) LH95_07765 ENOG4105F23 Fibronectin-binding protein LH95_07790 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) LH95_07795 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) LH95_07800 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) LH95_07805 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) LH95_07810 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain LH95_07815 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain LH95_07820 ENOG4105CD3 dihydroorotase LH95_07835 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) LH95_07840 ENOG4105C34 Pseudouridine synthase LH95_07850 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) LH95_07865 ENOG41067XK integral membrane protein LH95_07870 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) LH95_07875 ENOG4105DFA alanine racemase domain protein LH95_07880 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase LH95_07885 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) LH95_07890 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) LH95_07900 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) LH95_07905 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) LH95_07910 ENOG4105CJN penicillin-binding protein LH95_07915 ENOG41068DC Essential cell division protein (By similarity) LH95_07920 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) LH95_07925 ENOG4108V6E Cell division protein mraZ LH95_07930 ENOG41074B2 UPF0747 protein LH95_07935 ENOG4108YG3 N-acetyltransferase LH95_07940 ENOG4105PAD Hydrolase LH95_07950 ENOG4105CZN Potassium uptake protein LH95_07995 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) LH95_08005 ENOG4105E33 succinate dehydrogenase LH95_08015 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit LH95_08020 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) LH95_08025 ENOG4105K63 Thioredoxin LH95_08030 ENOG4105C98 muts2 protein LH95_08035 ENOG4105DCG PHP domain protein LH95_08050 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) LH95_08055 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) LH95_08060 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) LH95_08065 ENOG4108RWN rrna methyltransferase LH95_08070 ENOG41067VY 50S ribosomal protein L32 LH95_08085 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) LH95_08090 ENOG4106H78 methyltransferase LH95_08105 ENOG4107VXM glycerophosphoryl diester phosphodiesterase LH95_08125 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) LH95_08130 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) LH95_08135 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) LH95_08140 ENOG4105CNI cell division protein FtsW LH95_08145 ENOG4105ZPI UPF0358 protein LH95_08160 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase LH95_08165 ENOG4105CI3 gtp-binding protein typa LH95_08175 ENOG4105ECY inositol monophosphatase LH95_08195 ENOG4107RUE extracellular solute-binding protein family 1 LH95_08200 ENOG4105D38 putrescine abc transporter LH95_08210 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) LH95_08220 ENOG4105WBI UPF0223 protein LH95_08225 ENOG4107QN2 dihydrolipoyl dehydrogenase LH95_08230 ENOG4105C7S Dehydrogenase LH95_08235 ENOG4105CPP Dehydrogenase, E1 component LH95_08250 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) LH95_08260 ENOG4106148 UPF0356 protein LH95_08265 ENOG4105CN5 Metallo-Beta-Lactamase LH95_08270 ENOG4107ZYR domain protein LH95_08295 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) LH95_08310 ENOG4105DR4 Methyltransferase LH95_08330 ENOG4108JJB ABC transporter LH95_08340 ENOG4105C12 Phosphoribosylglycinamide synthetase LH95_08345 ENOG4105DC1 bifunctional purine biosynthesis protein purh LH95_08350 ENOG4108V3E phosphoribosylglycinamide formyltransferase LH95_08355 ENOG4105CXB phosphoribosylaminoimidazole synthetase LH95_08365 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii LH95_08370 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I LH95_08375 ENOG4105VR9 phosphoribosylformylglycinamidine synthase LH95_08380 ENOG4105C8V SAICAR synthetase LH95_08385 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit LH95_08390 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) LH95_08395 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) LH95_08400 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) LH95_08415 ENOG4105E2S oxidase) subunit II LH95_08425 ENOG4105CCU oxidase (Subunit III) LH95_08430 ENOG41060D1 Quinol oxidase LH95_08440 ENOG4106849 propeptide, pepSY amd peptidase M4 LH95_08450 ENOG4105EY8 ABC transporter LH95_08470 ENOG4105Q84 sucrose synthase LH95_08500 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain LH95_08510 ENOG4108KGH TRANSCRIPTIONal LH95_08520 ENOG41082BV acetyltransferase LH95_08530 ENOG4105EXC Acyl-transferase LH95_08535 ENOG4108TGC Acyltransferase LH95_08540 ENOG4105CHM Aminotransferase LH95_08545 ENOG4108IPT Naphthoate synthase LH95_08550 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) LH95_08555 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) LH95_08560 ENOG4105E4F Isochorismate synthase LH95_08565 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase LH95_08570 ENOG4105C4B ABC transporter, permease LH95_08575 ENOG41083J0 (ABC) transporter LH95_08605 ENOG4105EKQ RNA-directed DNA polymerase LH95_08625 ENOG4105XVF Competence transcription factor LH95_08650 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein LH95_08655 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic LH95_08665 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein LH95_08675 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD LH95_08685 ENOG4105C0H protease LH95_08690 ENOG4107TS3 membrane protein, TerC LH95_08705 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) LH95_08710 ENOG4108QBV Monogalactosyldiacylglycerol synthase LH95_08715 ENOG4108PK2 permease that is required for glycolipid anchoring of LTA. May facilitate the transport of diglucosyl- diacylglycerol (Glc2-DAG) from the inner to the outer leaflet of the cytoplasmic membrane, delivering Glc2-DAG as a substrate for LTA synthesis, thereby generating glycolipid-anchored LTA. Appears to play an important role in virulence LH95_08730 ENOG4105BZG amino acid carrier protein LH95_08735 ENOG4105C02 permease LH95_08770 ENOG4105CJW magnesium transporter LH95_08775 ENOG4105EMS pseudouridine synthase LH95_08780 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) LH95_08790 ENOG4106EFP UPF0738 protein LH95_08795 ENOG4105MIX Adenylate cyclase LH95_08800 ENOG4108Z18 K06886 hemoglobin LH95_08805 ENOG4105T58 Dithiol-disulfide isomerase LH95_08810 ENOG4105DPN Oligoendopeptidase f LH95_08830 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) LH95_08835 ENOG4105C31 Tryptophanyl-tRNA synthetase LH95_08845 ENOG4108JQ7 (ABC) transporter LH95_08855 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LH95_08860 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LH95_08870 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) LH95_08885 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family LH95_08890 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit LH95_08905 ENOG4108KP7 hydrolase LH95_08910 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase LH95_08915 ENOG4106BKT UPF0344 protein LH95_08920 ENOG4105ERH Fumarylacetoacetate hydrolase LH95_08925 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation LH95_08930 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination LH95_08950 ENOG4105CDH Citrulline--aspartate ligase LH95_08960 ENOG4107VXM glycerophosphoryl diester phosphodiesterase LH95_08965 ENOG4105D82 Glutamate dehydrogenase LH95_08970 ENOG4105C8Y Acetylornithine aminotransferase LH95_08975 ENOG4105C26 Dehydrogenase LH95_08980 ENOG41060GV RNA binding s1 domain protein LH95_09005 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) LH95_09010 ENOG4105Y38 Kinase-associated protein B LH95_09015 ENOG4105D65 subunit l LH95_09025 ENOG4105MKQ Monovalent cation H antiporter subunit C LH95_09030 ENOG4108JPZ Monovalent cation H antiporter subunit D LH95_09035 ENOG4105SC1 monovalent cation H antiporter subunit E LH95_09040 ENOG4105W4C monovalent cation H antiporter subunit F LH95_09050 ENOG4105KA0 thioesterase Superfamily protein LH95_09055 ENOG4105D3Y Na H antiporter LH95_09060 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) LH95_09065 ENOG4105CEP NADH dehydrogenase LH95_09075 ENOG4108YX9 iron--sulfur cluster insertion protein erpA LH95_09080 ENOG4105ZKE UPF0349 protein LH95_09095 ENOG41083MR nifu domain-containing protein LH95_09100 ENOG4105C5I Dehydrogenase LH95_09105 ENOG4105D4U had-superfamily hydrolase, subfamily iia LH95_09120 ENOG4105MMD transcriptional regulator LH95_09125 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) LH95_09130 ENOG4107R8B 5'-nucleotidase LH95_09140 ENOG4105I3N Conserved Protein LH95_09150 ENOG4105EA8 2-Nitropropane dioxygenase LH95_09155 ENOG4108JU6 CBS domain protein LH95_09195 ENOG4105DIW FeS assembly protein SUFB LH95_09200 ENOG4108UNV SUF system FeS assembly protein, NifU family LH95_09205 ENOG4105C9B Cysteine desulfurase LH95_09210 ENOG4105JRK feS assembly protein SufD LH95_09215 ENOG4105C3K feS assembly ATPase SufC LH95_09225 ENOG4105D01 (LipO)protein LH95_09230 ENOG4105D01 (LipO)protein LH95_09235 ENOG4108UMI ABC transporter, permease LH95_09240 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) LH95_09260 ENOG41080E8 Transcriptional regulator, Spx MgsR family LH95_09265 ENOG4105SZ6 Thioredoxin LH95_09275 ENOG4105FF2 Type I DHQase LH95_09285 ENOG4108ZHJ Organic hydroperoxide resistance protein LH95_09295 ENOG4105FQP Beta-lactamase LH95_09310 ENOG4105IE8 Alpha-ketoglutarate permease LH95_09330 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) LH95_09335 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) LH95_09345 ENOG4105XZU Preprotein translocase, subunit SecG LH95_09360 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) LH95_09365 ENOG4105CP7 Triose-phosphate isomerase LH95_09370 ENOG4105BZA Phosphoglycerate kinase LH95_09375 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase LH95_09400 ENOG4105ECP epimerase LH95_09405 ENOG4108Z7F N-acetyltransferase LH95_09410 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) LH95_09420 ENOG4105CIE May be required for sporulation (By similarity) LH95_09425 ENOG4105CHW UPF0052 protein LH95_09430 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) LH95_09435 ENOG4105C3M thioredoxin reductase LH95_09445 ENOG4108S4C acetyltransferase LH95_09455 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) LH95_09465 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) LH95_09485 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) LH95_09490 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving LH95_09515 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein LH95_09520 ENOG4105ESV Glycosyl transferase, family 4 LH95_09540 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) LH95_09545 ENOG4105BZW Glycerate kinase LH95_09565 ENOG4105D4A Cell wall formation (By similarity) LH95_09575 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) LH95_09580 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) LH95_09595 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) LH95_09600 ENOG4105DUX Transporter LH95_09605 ENOG4105DUX Transporter LH95_09615 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C LH95_09620 ENOG4105CIH Imidazole acetol-phosphate transaminase LH95_09625 ENOG4105E90 ABC transporter LH95_09630 ENOG4108IJ8 ABC transporter LH95_09635 ENOG4105C9U ATP-dependent DNA helicase RecQ LH95_09640 ENOG4105C5H ABC transporter LH95_09650 ENOG4105E0M Sulfatase LH95_09655 ENOG4107R7A Allophanate hydrolase subunit 2 LH95_09660 ENOG4105P4J Allophanate hydrolase, subunit 1 LH95_09675 ENOG4105CRQ synthase (Component I) LH95_09680 ENOG4105DDQ anthranilate synthase LH95_09690 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase LH95_09695 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) LH95_09705 ENOG4107BMA Transglycosylase associated protein LH95_09715 ENOG4105CKK Glycosyl transferase, family 2 LH95_09720 ENOG4105C37 (CBS) domain LH95_09725 ENOG4105DM4 PTS System LH95_09730 ENOG4105DE4 1-phosphofructokinase LH95_09735 ENOG4105E98 transcriptional regulator DeoR family LH95_09740 ENOG4108Z66 YbaK ebsC protein LH95_09745 ENOG4107SJB teichoic acid biosynthesis LH95_09750 ENOG4105DP8 Major facilitator superfamily MFS_1 LH95_09770 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) LH95_09780 ENOG4107QM2 Aldo Keto reductase LH95_09790 ENOG41083AI transcriptional regulator), MarR family LH95_09795 ENOG4108JJ8 (ABC) transporter LH95_09800 ENOG4108JJ9 ABC, transporter LH95_09805 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) LH95_09815 ENOG4107XJU UPF0178 protein LH95_09820 ENOG4108URH decarboxylase LH95_09850 ENOG4105S8Q sugar efflux transporter LH95_09870 ENOG4105CDY transcriptional regulatory protein LH95_09875 ENOG4105D06 uba thif-type nad fad binding protein LH95_09885 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) LH95_09890 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) LH95_09900 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) LH95_09905 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) LH95_09910 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) LH95_09920 ENOG4105C08 Histidine kinase LH95_09935 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein LH95_09960 ENOG4105VRS hydrolase family 18 LH95_09965 ENOG4105CJ3 phosphate transporter LH95_09970 ENOG4107GRR phosphate transport regulator LH95_09980 ENOG4105C19 ABC transporter LH95_09990 ENOG4105CJZ response regulator LH95_10010 ENOG4108K88 Membrane LH95_10020 ENOG4105EHG Permease protein LH95_10025 ENOG4105DQ5 transport system permease protein LH95_10030 ENOG4105E0A ABC, transporter LH95_10035 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) LH95_10085 ENOG4105BZ1 (ABC) transporter LH95_10095 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase LH95_10110 ENOG4105EY8 ABC transporter LH95_10115 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family LH95_10125 ENOG4105KST dependent repressor LH95_10130 ENOG4105DIK (ABC) transporter LH95_10135 ENOG4105CC5 ABC transporter LH95_10140 ENOG4105DSE periplasmic solute binding protein LH95_10145 ENOG4105KJM monovalent cation h antiporter subunit g LH95_10150 ENOG410684G monovalent cation H antiporter subunit F LH95_10155 ENOG4105IMY monovalent cation H antiporter subunit E LH95_10165 ENOG4105MKQ Monovalent cation H antiporter subunit C LH95_10170 ENOG4108PMQ Na H antiporter MnhB subunit-related protein LH95_10175 ENOG4105C8S subunit m LH95_10225 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) LH95_10230 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) LH95_10235 ENOG4105EHG Permease protein LH95_10240 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) LH95_10245 ENOG4105C75 arginyL-tRNA synthetase LH95_10255 ENOG4108XFG YwhD family LH95_10260 ENOG4105DCI Phosphohydrolase LH95_10270 ENOG4108WS4 fmn reductase LH95_10275 ENOG4105QAT UPF0741 protein LH95_10280 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) LH95_10285 ENOG4108IJ2 phosphate acetyltransferase LH95_10310 ENOG4105C8P )-transporter LH95_10315 ENOG4105C0R drug resistance transporter emrb qaca subfamily LH95_10320 ENOG4105CW7 secretion protein, HlyD family LH95_10330 ENOG4108Z9I -acetyltransferase LH95_10340 ENOG4105M08 Membrane LH95_10355 ENOG4105DWF phosphomethylpyrimidine kinase LH95_10370 ENOG4105CHU acetyl-coa acetyltransferase LH95_10375 ENOG4107F3J Amp-dependent synthetase and ligase LH95_10380 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) LH95_10385 ENOG4105EW6 flavin reductase domain protein, FMN-binding LH95_10395 ENOG4108VA3 3-hexulose-6-phosphate synthase LH95_10400 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) LH95_10420 ENOG4108TN2 lmbE family LH95_10430 ENOG410667J hydrolase LH95_10435 ENOG4108Z6B deaminase LH95_10445 ENOG4105ZMH deoxynucleoside kinase LH95_10455 ENOG4105CM2 brancheD-chain amino acid aminotransferase LH95_10460 ENOG4105EXW epimerase dehydratase LH95_10480 ENOG4107FQX Alpha-acetolactate decarboxylase LH95_10490 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) LH95_10495 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) LH95_10500 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) LH95_10505 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) LH95_10515 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) LH95_10520 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) LH95_10525 ENOG4107Y49 methyltransferase LH95_10535 ENOG4108VZM 50s ribosomal protein L10 LH95_10540 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) LH95_10545 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) LH95_10550 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) LH95_10555 ENOG410683Z Preprotein translocase SecE subunit LH95_10570 ENOG4105C2N RNA methyltransferase TrmH family group 3 LH95_10575 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) LH95_10580 ENOG4105C8N cysteinyl-tRNA synthetase LH95_10585 ENOG4105D7W serine acetyltransferase LH95_10590 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) LH95_10595 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) LH95_10600 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) LH95_10605 ENOG4105CTP PilT protein domain protein LH95_10610 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) LH95_10620 ENOG41066A3 ATP guanido phosphotransferase LH95_10625 ENOG4108Z0C Uvrb UvrC protein LH95_10630 ENOG4105KEX transcriptional regulator, ctsr LH95_10635 ENOG4105D9N nucleoside LH95_10640 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) LH95_10645 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) LH95_10650 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LH95_10655 ENOG4105ME7 Membrane LH95_10745 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase LH95_10755 ENOG4105EEI dihydropteroate synthase LH95_10760 ENOG4105C6T cysteine synthase LH95_10765 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) LH95_10770 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) LH95_10775 ENOG4108UGV hypoxanthine phosphoribosyltransferase LH95_10780 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) LH95_10785 ENOG41060GV RNA binding s1 domain protein LH95_10795 ENOG41082I2 s4 domain protein LH95_10800 ENOG4108IY2 MazG family LH95_10810 ENOG4108JA2 transcriptioN-repair coupling factor LH95_10815 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) LH95_10825 ENOG4105C5T Phosphoribosyl pyrophosphate synthase LH95_10830 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) LH95_10835 ENOG4105K4W Could be involved in septation (By similarity) LH95_10840 ENOG4105KME endoribonuclease L-psp LH95_10845 ENOG4105DFT pur operon repressor LH95_10850 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) LH95_10855 ENOG4105W42 Veg protein LH95_10865 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) LH95_10870 ENOG4105F8V Hydrolase, tatD family LH95_10880 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) LH95_10885 ENOG4105VC4 domain protein LH95_10890 ENOG41060K3 Methyltransferase LH95_10900 ENOG4105MA4 psp1 domain protein LH95_10910 ENOG4105X0R protein from nitrogen regulatory protein P-II LH95_10915 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) LH95_10920 ENOG4105CXN decarboxylase LH95_10945 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) LH95_10950 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) LH95_10955 ENOG4105C6E dna polymerase iii LH95_10970 ENOG4105BZ8 glutamate synthase LH95_10975 ENOG4105CBC glutamate synthase LH95_10980 ENOG4105C5Q Transcriptional regulator LH95_10995 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) LH95_11010 ENOG4105ST3 Transcriptional regulator LH95_11030 ENOG4105C28 cystathionine LH95_11045 ENOG4105EBR Carboxylesterase LH95_11050 ENOG4105C8J )-transporter LH95_11060 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) LH95_11065 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) LH95_11075 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) LH95_11090 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) LH95_11110 ENOG4108W0I acetyltransferase LH95_11125 ENOG4108S9F abc transporter, atp-binding protein LH95_11130 ENOG4108RZA ABC transporter LH95_11135 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LH95_11140 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LH95_11180 ENOG4105K78 MarR family Transcriptional regulator LH95_11185 ENOG4107XZQ multidrug resistance protein LH95_11195 ENOG4105J1V Triacylglycerol lipase LH95_11205 ENOG4105EWC Purine nucleoside phosphorylase LH95_11210 ENOG4107ZXU DSBA oxidoreductase LH95_11215 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) LH95_11250 ENOG4105KNA -acetyltransferase LH95_11320 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) LH95_11325 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) LH95_11330 ENOG4105C2W permease LH95_11335 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) LH95_11360 ENOG4107R6U sodium dicarboxylate symporter LH95_11365 ENOG4108DBC nitroreductase LH95_11370 ENOG4105D3R alkyl hydroperoxide reductase LH95_11375 ENOG4108JU3 Alkyl hydroperoxide reductase LH95_11380 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) LH95_11385 ENOG4108ZMX Domain of unknown function (DU1801) LH95_11390 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) LH95_11395 ENOG4108UMI ABC transporter, permease LH95_11400 ENOG4105D01 (LipO)protein LH95_11405 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) LH95_11410 ENOG4105F27 Major Facilitator LH95_11415 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) LH95_11420 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) LH95_11425 ENOG4108UUM single-stranded DNA-binding protein LH95_11430 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) LH95_11445 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases LH95_11450 ENOG4105C3G gtp-binding protein LH95_11455 ENOG4105VDK protein, conserved in bacteria LH95_11460 ENOG4105D8X mechanosensitive ion channel LH95_11465 ENOG4105FA0 parb-like partition protein LH95_11470 ENOG4105C28 cystathionine LH95_11475 ENOG4105C28 cystathionine LH95_11495 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) LH95_11505 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) LH95_11510 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) LH95_11515 ENOG4108YYC ycei family LH95_11520 ENOG41090MY MarR family Transcriptional regulator LH95_11530 ENOG4107XC4 flavin reductase domain protein, FMN-binding LH95_11535 ENOG4105FBA Phospholipase Carboxylesterase LH95_11560 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) LH95_11565 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) LH95_11570 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) LH95_11575 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) LH95_11580 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)