locus-tag	class	description
AOT14_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AOT14_00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AOT14_00040	COG0187	DNA topoisomerase II activity
AOT14_00060	COG0501	Belongs to the peptidase M48B family
AOT14_00140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOT14_00160	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AOT14_00190	COG4772	TonB-dependent receptor
AOT14_00210	COG0800	Aldolase
AOT14_00220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOT14_00230	COG4771	TonB-dependent receptor
AOT14_00270	COG2272	Belongs to the type-B carboxylesterase lipase family
AOT14_00280	COG0657	acetylesterase activity
AOT14_00280	COG2755	lipolytic protein G-D-S-L family
AOT14_00300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AOT14_00330	COG1609	Transcriptional regulator
AOT14_00340	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_00360	COG0302	gtp cyclohydrolase
AOT14_00370	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AOT14_00410	COG3012	SEC-C Motif Domain Protein
AOT14_00420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AOT14_00430	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AOT14_00440	COG0676	glucose-6-phosphate 1-epimerase activity
AOT14_00450	COG3135	benzoate transporter
AOT14_00530	COG4942	peptidase
AOT14_00540	COG0793	Belongs to the peptidase S41A family
AOT14_00610	COG1565	acr, cog1565
AOT14_00610	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AOT14_00620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AOT14_00640	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AOT14_00730	COG0358	DNA primase activity
AOT14_00740	COG1295	ribonuclease BN
AOT14_00750	COG1610	YqeY-like protein
AOT14_00760	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AOT14_00770	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AOT14_00780	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AOT14_00790	COG0668	transmembrane transport
AOT14_00820	COG2133	pyrroloquinoline quinone binding
AOT14_00830	COG1301	dicarboxylic acid transport
AOT14_00850	COG1737	Transcriptional regulator
AOT14_00870	COG4948	Mandelate Racemase Muconate Lactonizing
AOT14_00910	COG0019	diaminopimelate decarboxylase activity
AOT14_00920	COG3023	N-Acetylmuramoyl-L-alanine amidase
AOT14_00950	COG3023	N-Acetylmuramoyl-L-alanine amidase
AOT14_00960	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AOT14_00970	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AOT14_01020	COG5383	Protein conserved in bacteria
AOT14_01040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT14_01050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_01060	COG1473	amidohydrolase
AOT14_01070	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AOT14_01070	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AOT14_01080	COG1652	LysM domain
AOT14_01130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AOT14_01140	COG3118	belongs to the thioredoxin family
AOT14_01160	COG2884	Cell division ATP-binding protein ftsE
AOT14_01170	COG2177	Part of the ABC transporter FtsEX involved in
AOT14_01180	COG2201	protein-glutamate methylesterase activity
AOT14_01190	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AOT14_01200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AOT14_01220	COG1252	NADH dehydrogenase
AOT14_01240	COG0625	glutathione transferase activity
AOT14_01260	COG3537	Alpha-1,2-mannosidase
AOT14_01290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOT14_01350	COG4585	Histidine kinase
AOT14_01380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AOT14_01410	COG0534	Mate efflux family protein
AOT14_01420	COG0616	signal peptide processing
AOT14_01440	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_01460	COG0745	RESPONSE REGULATOR receiver
AOT14_01490	COG0009	L-threonylcarbamoyladenylate synthase
AOT14_01500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AOT14_01500	COG1754	DNA topoisomerase type I activity
AOT14_01510	COG1714	RDD family
AOT14_01530	COG2922	Belongs to the Smg family
AOT14_01540	COG0758	DNA mediated transformation
AOT14_01560	COG0242	peptide deformylase activity
AOT14_01570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AOT14_01580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AOT14_01580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AOT14_01600	COG1215	transferase activity, transferring glycosyl groups
AOT14_01670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AOT14_01690	COG1490	D-aminoacyl-tRNA deacylase activity
AOT14_01700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AOT14_01710	COG3537	Alpha-1,2-mannosidase
AOT14_01730	COG0582	viral genome integration into host DNA
AOT14_01740	COG1309	transcriptional regulator
AOT14_01770	COG1764	response to oxidative stress
AOT14_01800	COG4716	Myosin-crossreactive antigen
AOT14_01810	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOT14_01840	COG0210	DNA helicase
AOT14_01890	COG0514	ATP-dependent DNA helicase (RecQ)
AOT14_01960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AOT14_01990	COG1401	restriction endodeoxyribonuclease activity
AOT14_02040	COG5377	YqaJ viral recombinase family
AOT14_02070	COG2003	Belongs to the UPF0758 family
AOT14_02090	COG2963	transposase activity
AOT14_02120	COG4983	Phage plasmid primase, P4 family domain protein
AOT14_02200	COG0464	growth
AOT14_02210	COG2801	Transposase and inactivated derivatives
AOT14_02220	COG2963	transposase activity
AOT14_02260	COG3275	phosphorelay sensor kinase activity
AOT14_02290	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AOT14_02340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AOT14_02360	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AOT14_02380	COG1595	DNA-templated transcription, initiation
AOT14_02410	COG3046	protein related to deoxyribodipyrimidine photolyase
AOT14_02460	COG2200	EAL domain
AOT14_02470	COG3706	GGDEF domain
AOT14_02500	COG5001	Diguanylate cyclase
AOT14_02500	COG5002	protein histidine kinase activity
AOT14_02590	COG3795	YCII-related domain
AOT14_02600	COG3795	YCII-related domain
AOT14_02630	COG5507	3-demethylubiquinone-9 3-methyltransferase
AOT14_02640	COG4941	Belongs to the sigma-70 factor family
AOT14_02660	COG2972	Histidine kinase
AOT14_02710	COG3590	peptidase
AOT14_02740	COG0583	DNA-binding transcription factor activity
AOT14_02750	COG3384	dioxygenase
AOT14_02760	COG0025	NhaP-type Na H and K H
AOT14_02850	COG1522	sequence-specific DNA binding
AOT14_02860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOT14_02890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOT14_02890	COG2205	protein histidine kinase activity
AOT14_02910	COG1187	pseudouridine synthase activity
AOT14_02920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AOT14_02940	COG1666	GTP binding
AOT14_02960	COG0697	spore germination
AOT14_02980	COG2011	ABC-type metal ion transport system permease component
AOT14_03030	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOT14_03040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOT14_03070	COG0356	it plays a direct role in the translocation of protons across the membrane
AOT14_03090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AOT14_03100	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AOT14_03110	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AOT14_03120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AOT14_03130	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AOT14_03140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AOT14_03160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AOT14_03170	COG4191	Histidine kinase
AOT14_03180	COG2204	response regulator
AOT14_03190	COG1136	(ABC) transporter
AOT14_03190	COG0577	efflux transmembrane transporter activity
AOT14_03230	COG1136	(ABC) transporter
AOT14_03230	COG0577	efflux transmembrane transporter activity
AOT14_03240	COG0577	efflux transmembrane transporter activity
AOT14_03240	COG1136	(ABC) transporter
AOT14_03250	COG0577	efflux transmembrane transporter activity
AOT14_03250	COG1136	(ABC) transporter
AOT14_03260	COG0577	efflux transmembrane transporter activity
AOT14_03260	COG1136	(ABC) transporter
AOT14_03270	COG0577	efflux transmembrane transporter activity
AOT14_03270	COG1136	(ABC) transporter
AOT14_03280	COG1136	(ABC) transporter
AOT14_03300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AOT14_03320	COG3710	Transcriptional regulator
AOT14_03320	COG0457	Tetratricopeptide repeat
AOT14_03350	COG4206	TonB-dependent receptor
AOT14_03420	COG2132	Multicopper oxidase
AOT14_03450	COG0339	signal peptide processing
AOT14_03540	COG1803	Methylglyoxal synthase
AOT14_03550	COG0493	'glutamate synthase
AOT14_03560	COG0070	glutamate synthase
AOT14_03560	COG0067	glutamate synthase
AOT14_03560	COG0069	glutamate synthase activity
AOT14_03630	COG1111	helicase
AOT14_03630	COG1205	dead DEAH box helicase
AOT14_03690	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AOT14_03700	COG2885	chlorophyll binding
AOT14_03760	COG0714	Associated with various cellular activities
AOT14_03870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOT14_03890	COG2062	phosphohistidine phosphatase, SixA
AOT14_03910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOT14_03950	COG2202	Pas domain
AOT14_03950	COG2200	EAL domain
AOT14_03950	COG2199	diguanylate cyclase activity
AOT14_04010	COG1968	undecaprenyl-diphosphatase activity
AOT14_04020	COG0174	glutamine synthetase
AOT14_04040	COG0004	ammonium transporteR
AOT14_04050	COG3852	Histidine kinase
AOT14_04060	COG2204	response regulator
AOT14_04070	COG0515	serine threonine protein kinase
AOT14_04070	COG2815	serine threonine protein kinase
AOT14_04080	COG2032	superoxide dismutase activity
AOT14_04090	COG2032	superoxide dismutase activity
AOT14_04110	COG0183	Belongs to the thiolase family
AOT14_04210	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AOT14_04220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AOT14_04240	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_04290	COG3474	cytochrome
AOT14_04330	COG0454	-acetyltransferase
AOT14_04400	COG3039	Transposase
AOT14_04440	COG0129	dihydroxy-acid dehydratase activity
AOT14_04460	COG0754	glutathionylspermidine amidase activity
AOT14_04500	COG0714	Associated with various cellular activities
AOT14_04570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AOT14_04750	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AOT14_04760	COG1040	competence protein
AOT14_04800	COG2207	Transcriptional regulator
AOT14_04820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AOT14_04880	COG0606	chelatase, subunit chli
AOT14_04910	COG3039	Transposase
AOT14_05000	COG0251	oxidation-reduction process
AOT14_05010	COG0583	DNA-binding transcription factor activity
AOT14_05020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOT14_05040	COG3039	Transposase
AOT14_05060	COG3039	Transposase
AOT14_05120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOT14_05130	COG0625	glutathione transferase activity
AOT14_05190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AOT14_05240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOT14_05250	COG0604	alcohol dehydrogenase
AOT14_05420	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AOT14_05500	COG0606	chelatase, subunit chli
AOT14_05510	COG2960	long-chain fatty acid transporting porin activity
AOT14_05570	COG1166	arginine decarboxylase activity
AOT14_05580	COG4221	oxidoreductase activity
AOT14_05600	COG0018	arginyl-trna synthetase
AOT14_05610	COG2003	Belongs to the UPF0758 family
AOT14_05620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AOT14_05660	COG2205	protein histidine kinase activity
AOT14_05680	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AOT14_05690	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AOT14_05730	COG0708	Exodeoxyribonuclease III
AOT14_05740	COG2223	nitrite transmembrane transporter activity
AOT14_05760	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AOT14_05770	COG0739	heme binding
AOT14_05780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AOT14_05870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AOT14_05880	COG0546	phosphoglycolate phosphatase activity
AOT14_05890	COG4206	TonB-dependent receptor
AOT14_05910	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AOT14_05920	COG0406	alpha-ribazole phosphatase activity
AOT14_05930	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AOT14_05950	COG1956	GAF domain-containing protein
AOT14_05980	COG0720	synthase
AOT14_05990	COG0513	Belongs to the DEAD box helicase family
AOT14_06010	COG0625	glutathione transferase activity
AOT14_06070	COG0626	cystathionine gamma-synthase activity
AOT14_06090	COG1450	Type ii and iii secretion system protein
AOT14_06200	COG1459	type II secretion system
AOT14_06240	COG0438	transferase activity, transferring glycosyl groups
AOT14_06240	COG1216	Glycosyl transferase, family 2
AOT14_06260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AOT14_06270	COG2076	Multidrug Resistance protein
AOT14_06300	COG0318	PFAM AMP-dependent synthetase and ligase
AOT14_06310	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_06420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOT14_06460	COG2409	Drug exporters of the RND superfamily
AOT14_06500	COG0181	hydroxymethylbilane synthase activity
AOT14_06530	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AOT14_06570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AOT14_06630	COG1505	serine-type exopeptidase activity
AOT14_06640	COG0436	Aminotransferase
AOT14_06660	COG2832	Protein of unknown function (DUF454)
AOT14_06680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AOT14_06730	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AOT14_06740	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AOT14_06750	COG1309	transcriptional regulator
AOT14_06760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_06770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT14_06800	COG2226	methyltransferase
AOT14_06810	COG0308	aminopeptidase N
AOT14_06860	COG1077	Cell shape determining protein MreB Mrl
AOT14_06870	COG1792	Involved in formation and maintenance of cell shape
AOT14_06890	COG0768	penicillin binding
AOT14_06900	COG0772	Belongs to the SEDS family
AOT14_06910	COG2951	lytic endotransglycosylase activity
AOT14_06930	COG1686	Belongs to the peptidase S11 family
AOT14_06960	COG2921	Belongs to the UPF0250 family
AOT14_06970	COG0321	lipoyl(octanoyl) transferase activity
AOT14_06980	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AOT14_07020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AOT14_07040	COG4251	negative regulation of phosphorylation
AOT14_07050	COG0784	Response regulator, receiver
AOT14_07060	COG4191	Histidine kinase
AOT14_07070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AOT14_07110	COG0662	Cupin 2, conserved barrel domain protein
AOT14_07120	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AOT14_07130	COG3876	Protein conserved in bacteria
AOT14_07140	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AOT14_07160	COG0837	glucose binding
AOT14_07170	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AOT14_07200	COG0837	glucose binding
AOT14_07210	COG0738	Major facilitator superfamily
AOT14_07220	COG1609	Transcriptional regulator
AOT14_07230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AOT14_07240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AOT14_07270	COG0617	tRNA 3'-terminal CCA addition
AOT14_07320	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOT14_07350	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AOT14_07360	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AOT14_07450	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AOT14_07460	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AOT14_07470	COG2203	Gaf domain
AOT14_07470	COG4251	negative regulation of phosphorylation
AOT14_07470	COG3706	GGDEF domain
AOT14_07470	COG5001	Diguanylate cyclase
AOT14_07500	COG1307	EDD domain protein, DegV family
AOT14_07510	COG1228	amidohydrolase
AOT14_07520	COG3964	amidohydrolase
AOT14_07540	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AOT14_07560	COG0513	Belongs to the DEAD box helicase family
AOT14_07600	COG0436	Aminotransferase
AOT14_07610	COG1162	GTPase activity
AOT14_07630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AOT14_07640	COG4206	TonB-dependent receptor
AOT14_07660	COG0583	DNA-binding transcription factor activity
AOT14_07670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOT14_07680	COG0405	Gamma-glutamyltransferase
AOT14_07700	COG3119	arylsulfatase activity
AOT14_07710	COG0641	radical SAM
AOT14_07720	COG0405	Gamma-glutamyltransferase
AOT14_07730	COG0786	glutamate:sodium symporter activity
AOT14_07750	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AOT14_07760	COG1737	Transcriptional regulator
AOT14_07770	COG2610	gluconate transmembrane transporter activity
AOT14_07800	COG2197	response regulator
AOT14_07820	COG3916	Acyl-homoserine-lactone synthase
AOT14_07850	COG0297	glycogen (starch) synthase activity
AOT14_07870	COG1560	Kdo2-lipid A biosynthetic process
AOT14_07880	COG1519	Transferase
AOT14_07890	COG1538	Outer membrane efflux protein
AOT14_07900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AOT14_07940	COG3706	GGDEF domain
AOT14_08000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AOT14_08000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AOT14_08010	COG0778	Nitroreductase
AOT14_08030	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AOT14_08070	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AOT14_08090	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AOT14_08120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AOT14_08130	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AOT14_08170	COG1295	ribonuclease BN
AOT14_08180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AOT14_08240	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AOT14_08250	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AOT14_08280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AOT14_08300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AOT14_08320	COG0193	aminoacyl-tRNA hydrolase activity
AOT14_08330	COG0012	GTP binding
AOT14_08340	COG4771	TonB-dependent receptor
AOT14_08360	COG1446	asparaginase
AOT14_08400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AOT14_08420	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AOT14_08430	COG0250	Participates in transcription elongation, termination and antitermination
AOT14_08440	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AOT14_08450	COG0081	regulation of translation
AOT14_08460	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AOT14_08470	COG0222	ribosome binding
AOT14_08480	COG0085	RNA polymerase activity
AOT14_08490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AOT14_08500	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AOT14_08520	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AOT14_08530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AOT14_08550	COG0051	transcription antitermination factor activity, RNA binding
AOT14_08560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AOT14_08570	COG0088	Forms part of the polypeptide exit tunnel
AOT14_08580	COG0089	rRNA binding
AOT14_08590	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AOT14_08600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AOT14_08610	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AOT14_08620	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AOT14_08630	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AOT14_08640	COG0255	Belongs to the universal ribosomal protein uL29 family
AOT14_08650	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AOT14_08660	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AOT14_08670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AOT14_08680	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AOT14_08690	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AOT14_08700	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AOT14_08720	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AOT14_08730	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AOT14_08740	COG1841	ribosomal large subunit assembly
AOT14_08750	COG0200	Binds to the 23S rRNA
AOT14_08760	COG0201	protein transport
AOT14_08770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AOT14_08780	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AOT14_08790	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AOT14_08800	COG0202	RNA polymerase activity
AOT14_08810	COG0203	ribosomal protein L17
AOT14_08820	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AOT14_08830	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AOT14_08850	COG0154	amidase activity
AOT14_08880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AOT14_08910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOT14_08940	COG2205	protein histidine kinase activity
AOT14_08950	COG0745	RESPONSE REGULATOR receiver
AOT14_08980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOT14_08990	COG0625	glutathione transferase activity
AOT14_09010	COG3039	Transposase
AOT14_09020	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOT14_09020	COG1902	pentaerythritol trinitrate reductase activity
AOT14_09060	COG1187	pseudouridine synthase activity
AOT14_09100	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AOT14_09110	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AOT14_09120	COG4208	sulfate ABC transporter
AOT14_09130	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AOT14_09160	COG1063	alcohol dehydrogenase
AOT14_09190	COG0588	phosphoglycerate mutase activity
AOT14_09210	COG0285	dihydrofolate synthase activity
AOT14_09250	COG2833	Protein of unknown function (DUF455)
AOT14_09280	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT14_09300	COG0438	transferase activity, transferring glycosyl groups
AOT14_09310	COG0248	Ppx GppA phosphatase
AOT14_09320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AOT14_09330	COG5002	protein histidine kinase activity
AOT14_09350	COG4783	chaperone-mediated protein folding
AOT14_09380	COG0473	3-isopropylmalate dehydrogenase activity
AOT14_09460	COG0544	peptidyl-prolyl cis-trans isomerase activity
AOT14_09470	COG0740	serine-type endopeptidase activity
AOT14_09480	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AOT14_09550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOT14_09560	COG3942	CHAP domain
AOT14_09560	COG1388	LysM domain
AOT14_09570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOT14_09600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOT14_09610	COG0631	protein serine/threonine phosphatase activity
AOT14_09650	COG0859	PFAM glycosyl transferase family 9
AOT14_09660	COG3642	lipopolysaccharide core region biosynthetic process
AOT14_09670	COG1234	tRNA 3'-trailer cleavage
AOT14_09690	COG0582	viral genome integration into host DNA
AOT14_09760	COG0587	DNA-directed DNA polymerase activity
AOT14_09850	COG5377	YqaJ viral recombinase family
AOT14_09880	COG2801	Transposase and inactivated derivatives
AOT14_09890	COG2826	transposase and inactivated derivatives, IS30 family
AOT14_09900	COG2963	transposase activity
AOT14_09920	COG2801	Transposase and inactivated derivatives
AOT14_09990	COG3039	Transposase
AOT14_10080	COG3039	Transposase
AOT14_10110	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AOT14_10120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AOT14_10140	COG0537	adenosine 5'-monophosphoramidase activity
AOT14_10170	COG1305	Transglutaminase-like
AOT14_10190	COG0714	Associated with various cellular activities
AOT14_10240	COG1399	metal-binding, possibly nucleic acid-binding protein
AOT14_10250	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AOT14_10260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AOT14_10280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AOT14_10290	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_10310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AOT14_10320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AOT14_10330	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AOT14_10380	COG3540	Alkaline phosphatase
AOT14_10500	COG2818	Glycosylase
AOT14_10520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AOT14_10530	COG0540	Belongs to the ATCase OTCase family
AOT14_10560	COG2239	Acts as a magnesium transporter
AOT14_10570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AOT14_10600	COG1660	Displays ATPase and GTPase activities
AOT14_10610	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AOT14_10620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOT14_10650	COG1137	ATPase activity
AOT14_10680	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AOT14_10710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AOT14_10730	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOT14_10740	COG0564	pseudouridine synthase activity
AOT14_10770	COG3011	Protein conserved in bacteria
AOT14_10780	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AOT14_10790	COG3387	PFAM Glycoside hydrolase 15-related
AOT14_10800	COG1877	trehalose-phosphatase activity
AOT14_10880	COG1858	cytochrome C peroxidase
AOT14_10900	COG4771	TonB-dependent receptor
AOT14_10920	COG1595	DNA-templated transcription, initiation
AOT14_10930	COG0542	response to heat
AOT14_10960	COG0583	DNA-binding transcription factor activity
AOT14_10970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AOT14_10970	COG4651	solute:proton antiporter activity
AOT14_10980	COG4771	TonB-dependent receptor
AOT14_10990	COG0488	(ABC) transporter
AOT14_11060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AOT14_11100	COG4771	TonB-dependent receptor
AOT14_11120	COG0217	transcriptional regulatory protein
AOT14_11130	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AOT14_11140	COG0632	four-way junction helicase activity
AOT14_11160	COG2255	four-way junction helicase activity
AOT14_11170	COG0824	Thioesterase
AOT14_11220	COG2885	chlorophyll binding
AOT14_11240	COG0602	queuosine metabolic process
AOT14_11280	COG2815	serine threonine protein kinase
AOT14_11280	COG0515	serine threonine protein kinase
AOT14_11300	COG0783	Belongs to the Dps family
AOT14_11310	COG1643	Atp-dependent helicase
AOT14_11340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOT14_11370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AOT14_11390	COG1199	ATP-dependent helicase activity
AOT14_11400	COG1214	PFAM Peptidase M22, glycoprotease
AOT14_11420	COG0384	phenazine biosynthesis protein PhzF
AOT14_11430	COG0384	phenazine biosynthesis protein PhzF
AOT14_11440	COG0527	aspartate kinase activity
AOT14_11460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AOT14_11480	COG0142	geranyltranstransferase activity
AOT14_11490	COG0366	Alpha amylase catalytic
AOT14_11510	COG1082	Xylose isomerase domain protein TIM barrel
AOT14_11520	COG2211	Major facilitator Superfamily
AOT14_11520	COG2190	(PTS) system
AOT14_11580	COG0629	single-stranded DNA binding
AOT14_11600	COG0431	NADPH-dependent FMN reductase
AOT14_11630	COG0798	PFAM Bile acid sodium symporter
AOT14_11650	COG2197	response regulator
AOT14_11670	COG4948	Mandelate Racemase Muconate Lactonizing
AOT14_11690	COG4771	TonB-dependent receptor
AOT14_11710	COG3104	oligopeptide transport
AOT14_11720	COG1297	OPT oligopeptide transporter protein
AOT14_11730	COG1506	peptidase
AOT14_11730	COG0823	Involved in the tonB-independent uptake of proteins
AOT14_11760	COG2879	small protein
AOT14_11770	COG1966	Carbon starvation protein
AOT14_11800	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AOT14_11810	COG1741	Belongs to the pirin family
AOT14_11820	COG1515	deoxyribonuclease V activity
AOT14_11830	COG0588	phosphoglycerate mutase activity
AOT14_11890	COG3590	peptidase
AOT14_11930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AOT14_11950	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AOT14_11960	COG0745	RESPONSE REGULATOR receiver
AOT14_11970	COG2205	protein histidine kinase activity
AOT14_11980	COG5001	Diguanylate cyclase
AOT14_11980	COG5002	protein histidine kinase activity
AOT14_11990	COG4452	Inner membrane protein CreD
AOT14_12050	COG0824	Thioesterase
AOT14_12060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AOT14_12080	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AOT14_12100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AOT14_12130	COG0728	peptidoglycan biosynthetic process
AOT14_12160	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AOT14_12180	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AOT14_12210	COG3039	Transposase
AOT14_12230	COG4974	Belongs to the 'phage' integrase family
AOT14_12300	COG2963	transposase activity
AOT14_12310	COG4771	TonB-dependent receptor
AOT14_12360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AOT14_12370	COG1845	cytochrome c oxidase, subunit III
AOT14_12380	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AOT14_12430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AOT14_12440	COG2070	2-Nitropropane dioxygenase
AOT14_12470	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AOT14_12480	COG0336	Belongs to the RNA methyltransferase TrmD family
AOT14_12490	COG0335	large ribosomal subunit rRNA binding
AOT14_12500	COG1349	DNA-binding transcription factor activity
AOT14_12520	COG1940	carbohydrate kinase activity
AOT14_12530	COG2222	sugar isomerase
AOT14_12540	COG1501	Belongs to the glycosyl hydrolase 31 family
AOT14_12560	COG0673	inositol 2-dehydrogenase activity
AOT14_12570	COG0534	Mate efflux family protein
AOT14_12610	COG0753	catalase activity
AOT14_12630	COG1827	regulation of RNA biosynthetic process
AOT14_12680	COG3706	GGDEF domain
AOT14_12690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AOT14_12750	COG2217	Heavy metal translocating P-type atpase
AOT14_12790	COG2010	Cytochrome c
AOT14_12820	COG3278	Belongs to the heme-copper respiratory oxidase family
AOT14_12830	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AOT14_12840	COG1024	Enoyl-CoA hydratase
AOT14_12840	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOT14_12870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOT14_12880	COG0481	GTPase activity
AOT14_12890	COG0681	Belongs to the peptidase S26 family
AOT14_12920	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AOT14_12950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AOT14_12970	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AOT14_12980	COG1472	Belongs to the glycosyl hydrolase 3 family
AOT14_13000	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AOT14_13010	COG1278	Cold shock
AOT14_13020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT14_13070	COG2801	Transposase and inactivated derivatives
AOT14_13090	COG0840	transmembrane signaling receptor activity
AOT14_13090	COG0840	transmembrane signaling receptor activity
AOT14_13120	COG1960	acyl-CoA dehydrogenase activity
AOT14_13150	COG0183	Belongs to the thiolase family
AOT14_13180	COG1703	isobutyryl-CoA mutase activity
AOT14_13180	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AOT14_13180	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AOT14_13200	COG1619	proteins homologs of microcin C7 resistance protein MccF
AOT14_13210	COG1228	amidohydrolase
AOT14_13250	COG0745	RESPONSE REGULATOR receiver
AOT14_13250	COG3706	GGDEF domain
AOT14_13260	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOT14_13270	COG5002	protein histidine kinase activity
AOT14_13270	COG5001	Diguanylate cyclase
AOT14_13270	COG3447	MASE1 domain protein
AOT14_13280	COG0204	Acyl-transferase
AOT14_13330	COG2814	Major facilitator Superfamily
AOT14_13360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOT14_13370	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AOT14_13410	COG1451	nucleotide metabolic process
AOT14_13430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AOT14_13500	COG2824	Alkylphosphonate utilization operon protein PhnA
AOT14_13570	COG0392	lysyltransferase activity
AOT14_13570	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AOT14_13590	COG0251	oxidation-reduction process
AOT14_13600	COG2733	membrane
AOT14_13650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOT14_13670	COG0477	Major facilitator Superfamily
AOT14_13680	COG2703	oxygen carrier activity
AOT14_13690	COG0745	RESPONSE REGULATOR receiver
AOT14_13690	COG3706	GGDEF domain
AOT14_13700	COG0745	RESPONSE REGULATOR receiver
AOT14_13760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOT14_13780	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AOT14_13790	COG3842	ATPase activity
AOT14_13800	COG1176	ABC-type spermidine putrescine transport system, permease component I
AOT14_13810	COG1177	transmembrane transport
AOT14_13820	COG1012	belongs to the aldehyde dehydrogenase family
AOT14_13860	COG4535	Mg2 and Co2 transporter CorC
AOT14_13890	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AOT14_13910	COG1702	phosphate starvation-inducible protein PhoH
AOT14_13920	COG1309	transcriptional regulator
AOT14_13940	COG1131	(ABC) transporter
AOT14_13950	COG0842	Transport permease protein
AOT14_13950	COG1129	ABC transporter
AOT14_13960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AOT14_13970	COG0741	lytic transglycosylase activity
AOT14_13980	COG0723	plastoquinol--plastocyanin reductase activity
AOT14_13990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AOT14_14000	COG2857	Cytochrome c1
AOT14_14010	COG0625	glutathione transferase activity
AOT14_14020	COG2969	positive regulation of protein catabolic process
AOT14_14090	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AOT14_14100	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AOT14_14110	COG0300	oxidoreductase activity
AOT14_14120	COG2095	MarC family integral membrane protein
AOT14_14140	COG1611	Belongs to the LOG family
AOT14_14150	COG3275	phosphorelay sensor kinase activity
AOT14_14240	COG0556	nucleotide-excision repair
AOT14_14260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AOT14_14270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AOT14_14280	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AOT14_14290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AOT14_14300	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AOT14_14320	COG0776	regulation of translation
AOT14_14360	COG0348	domain, Protein
AOT14_14410	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AOT14_14420	COG0069	glutamate synthase activity
AOT14_14430	COG0493	'glutamate synthase
AOT14_14470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOT14_14490	COG1253	flavin adenine dinucleotide binding
AOT14_14510	COG0306	phosphate transporter
AOT14_14560	COG0504	CTP synthase activity
AOT14_14570	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AOT14_14590	COG0148	phosphopyruvate hydratase activity
AOT14_14600	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AOT14_14610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AOT14_14620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AOT14_14640	COG2840	Smr protein MutS2
AOT14_14650	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AOT14_14670	COG1238	metal cluster binding
AOT14_14710	COG1534	Rna-binding protein
AOT14_14720	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AOT14_14730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOT14_14750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AOT14_14760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AOT14_14780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AOT14_14810	COG0688	phosphatidylethanolamine metabolic process
AOT14_14830	COG2890	protein-(glutamine-N5) methyltransferase activity
AOT14_14850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AOT14_14860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AOT14_14890	COG0101	tRNA pseudouridine synthase activity
AOT14_14900	COG0135	phosphoribosylanthranilate isomerase activity
AOT14_14920	COG0133	tryptophan synthase activity
AOT14_14940	COG0159	tryptophan synthase activity
AOT14_14950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AOT14_14950	COG2755	lipolytic protein G-D-S-L family
AOT14_14960	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AOT14_14970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOT14_14980	COG0726	polysaccharide deacetylase
AOT14_15020	COG0149	triose-phosphate isomerase activity
AOT14_15050	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOT14_15060	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOT14_15070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOT14_15080	COG0649	NAD binding
AOT14_15090	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AOT14_15100	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AOT14_15180	COG1007	ATP synthesis coupled electron transport
AOT14_15200	COG0779	Required for maturation of 30S ribosomal subunits
AOT14_15210	COG0195	Participates in both transcription termination and antitermination
AOT14_15220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AOT14_15230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AOT14_15250	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AOT14_15270	COG2333	competence protein COMEC
AOT14_15270	COG0658	competence protein
AOT14_15290	COG0848	biopolymer transport protein
AOT14_15310	COG1663	tetraacyldisaccharide 4'-kinase activity
AOT14_15320	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AOT14_15330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AOT14_15350	COG0322	excinuclease ABC activity
AOT14_15440	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AOT14_15460	COG1960	acyl-CoA dehydrogenase activity
AOT14_15500	COG3712	iron ion homeostasis
AOT14_15510	COG1228	amidohydrolase
AOT14_15520	COG1473	amidohydrolase
AOT14_15530	COG3040	lipid binding
AOT14_15550	COG0745	RESPONSE REGULATOR receiver
AOT14_15550	COG3706	GGDEF domain
AOT14_15600	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AOT14_15620	COG1570	exodeoxyribonuclease VII activity
AOT14_15630	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AOT14_15640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AOT14_15640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AOT14_15650	COG0802	atpase or kinase
AOT14_15660	COG0860	N-Acetylmuramoyl-L-alanine amidase
AOT14_15670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AOT14_15720	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_15730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOT14_15740	COG0501	Belongs to the peptidase M48B family
AOT14_15780	COG3300	MHYT domain
AOT14_15780	COG5001	Diguanylate cyclase
AOT14_15790	COG1509	lysine 2,3-aminomutase activity
AOT14_15800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AOT14_15810	COG3548	integral membrane protein
AOT14_15820	COG0402	S-adenosylhomocysteine deaminase activity
AOT14_15900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AOT14_15920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AOT14_15940	COG2166	iron-sulfur cluster assembly
AOT14_15980	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AOT14_15990	COG0137	argininosuccinate synthase activity
AOT14_16000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AOT14_16010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AOT14_16040	COG0165	Argininosuccinate lyase
AOT14_16120	COG1294	oxidase, subunit
AOT14_16140	COG4988	ABC transporter
AOT14_16150	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AOT14_16160	COG1793	dna ligase
AOT14_16170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOT14_16190	COG4235	cytochrome complex assembly
AOT14_16200	COG3088	subunit of a heme lyase
AOT14_16210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AOT14_16230	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AOT14_16280	COG4133	protoheme IX ABC transporter activity
AOT14_16290	COG0436	Aminotransferase
AOT14_16330	COG1187	pseudouridine synthase activity
AOT14_16340	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AOT14_16350	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AOT14_16360	COG2350	Protein conserved in bacteria
AOT14_16430	COG0395	ABC-type sugar transport system, permease component
AOT14_16460	COG0800	Aldolase
AOT14_16470	COG0129	dihydroxy-acid dehydratase activity
AOT14_16490	COG0837	glucose binding
AOT14_16500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AOT14_16550	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AOT14_16600	COG4591	ABC-type transport system involved in lipoprotein release permease component
AOT14_16630	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AOT14_16640	COG1194	a g-specific adenine glycosylase
AOT14_16650	COG0552	protein localization to endoplasmic reticulum
AOT14_16670	COG0326	Molecular chaperone. Has ATPase activity
AOT14_16680	COG0742	ribosomal rna small subunit methyltransferase
AOT14_16690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AOT14_16710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AOT14_16720	COG0405	Gamma-glutamyltransferase
AOT14_16740	COG3135	benzoate transporter
AOT14_16760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AOT14_16770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOT14_16800	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AOT14_16850	COG0583	DNA-binding transcription factor activity
AOT14_16910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AOT14_16920	COG1522	sequence-specific DNA binding
AOT14_16930	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AOT14_16940	COG0343	queuine tRNA-ribosyltransferase activity
AOT14_16950	COG1862	Preprotein translocase
AOT14_16970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AOT14_16980	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AOT14_16990	COG2200	EAL domain
AOT14_17000	COG2081	HI0933 family
AOT14_17010	COG4681	YaeQ
AOT14_17050	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AOT14_17060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AOT14_17070	COG0513	Belongs to the DEAD box helicase family
AOT14_17090	COG0583	DNA-binding transcription factor activity
AOT14_17210	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AOT14_17220	COG0339	signal peptide processing
AOT14_17230	COG0386	Belongs to the glutathione peroxidase family
AOT14_17280	COG2860	membrane
AOT14_17290	COG2860	membrane
AOT14_17340	COG1393	Belongs to the ArsC family
AOT14_17410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AOT14_17420	COG0084	hydrolase, TatD family'
AOT14_17490	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AOT14_17500	COG1183	phosphatidylcholine synthase activity
AOT14_17520	COG3243	poly(R)-hydroxyalkanoic acid synthase
AOT14_17560	COG2183	response to ionizing radiation
AOT14_17660	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_17670	COG1335	isochorismatase
AOT14_17710	COG2823	Periplasmic or secreted lipoprotein
AOT14_17790	COG1064	alcohol dehydrogenase
AOT14_17800	COG1473	amidohydrolase
AOT14_17810	COG1595	DNA-templated transcription, initiation
AOT14_17820	COG4944	Protein of unknown function (DUF1109)
AOT14_17920	COG0840	transmembrane signaling receptor activity
AOT14_17930	COG3300	MHYT domain
AOT14_17930	COG5001	Diguanylate cyclase
AOT14_17940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AOT14_17990	COG4644	lycopene metabolic process
AOT14_18120	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AOT14_18230	COG0010	Belongs to the arginase family
AOT14_18240	COG2986	histidine ammonia-lyase
AOT14_18250	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AOT14_18260	COG2188	Transcriptional regulator
AOT14_18290	COG2871	sodium ion transport
AOT14_18340	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT14_18350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_18470	COG0789	Transcriptional regulator
AOT14_18500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOT14_18520	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AOT14_18530	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AOT14_18540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AOT14_18550	COG2217	Heavy metal translocating P-type atpase
AOT14_18600	COG5002	protein histidine kinase activity
AOT14_18650	COG0789	Transcriptional regulator
AOT14_18750	COG3039	Transposase
AOT14_18820	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AOT14_18980	COG0666	response to abiotic stimulus
AOT14_19030	COG3039	Transposase
AOT14_19080	COG3142	Participates in the control of copper homeostasis
AOT14_19090	COG1446	asparaginase
AOT14_19100	COG0837	glucose binding
AOT14_19120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AOT14_19130	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AOT14_19140	COG1674	ftsk spoiiie
AOT14_19150	COG0492	ferredoxin-NADP+ reductase activity
AOT14_19160	COG1408	metallophosphoesterase
AOT14_19210	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AOT14_19220	COG0542	response to heat
AOT14_19260	COG0482	sulfurtransferase activity
AOT14_19270	COG2915	High frequency lysogenization protein hflD homolog
AOT14_19330	COG5002	protein histidine kinase activity
AOT14_19370	COG0784	Response regulator, receiver
AOT14_19370	COG0835	chemotaxis
AOT14_19390	COG1558	bacterial-type flagellum-dependent cell motility
AOT14_19400	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AOT14_19410	COG1749	Flagellar hook protein flgE
AOT14_19420	COG4787	bacterial-type flagellum-dependent cell motility
AOT14_19430	COG4786	Flagellar basal body rod
AOT14_19440	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AOT14_19470	COG1256	bacterial-type flagellum assembly
AOT14_19570	COG2201	protein-glutamate methylesterase activity
AOT14_19610	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AOT14_19660	COG0438	transferase activity, transferring glycosyl groups
AOT14_19660	COG1216	Glycosyl transferase, family 2
AOT14_19680	COG1766	The M ring may be actively involved in energy transduction
AOT14_19690	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AOT14_19770	COG3190	flagellar
AOT14_19780	COG1338	Plays a role in the flagellum-specific transport system
AOT14_19790	COG1987	bacterial-type flagellum assembly
AOT14_19850	COG0455	bacterial-type flagellum organization
AOT14_19890	COG0643	Histidine kinase
AOT14_19890	COG2198	Histidine kinase
AOT14_19900	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AOT14_19930	COG0835	chemotaxis
AOT14_19950	COG0745	RESPONSE REGULATOR receiver
AOT14_19980	COG0840	transmembrane signaling receptor activity
AOT14_19990	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AOT14_20000	COG0835	chemotaxis
AOT14_20020	COG0840	transmembrane signaling receptor activity
AOT14_20030	COG0840	transmembrane signaling receptor activity
AOT14_20030	COG0840	transmembrane signaling receptor activity
AOT14_20060	COG2201	protein-glutamate methylesterase activity
AOT14_20230	COG1017	nitric oxide dioxygenase activity
AOT14_20230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOT14_20250	COG3706	GGDEF domain
AOT14_20260	COG2885	chlorophyll binding
AOT14_20260	COG3047	cAMP biosynthetic process
AOT14_20300	COG1024	Enoyl-CoA hydratase
AOT14_20310	COG2205	protein histidine kinase activity
AOT14_20310	COG0784	Response regulator, receiver
AOT14_20310	COG2198	Histidine kinase
AOT14_20330	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AOT14_20340	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AOT14_20370	COG3279	Response regulator of the LytR AlgR family
AOT14_20390	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AOT14_20410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOT14_20420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AOT14_20440	COG0505	Belongs to the CarA family
AOT14_20450	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AOT14_20460	COG2249	NAD(P)H dehydrogenase (quinone) activity
AOT14_20480	COG1918	ferrous iron import across plasma membrane
AOT14_20480	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AOT14_20550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AOT14_20590	COG0277	FAD linked oxidase domain protein
AOT14_20600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AOT14_20620	COG0531	amino acid
AOT14_20630	COG0531	amino acid
AOT14_20640	COG0235	Class ii aldolase
AOT14_20650	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AOT14_20660	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AOT14_20670	COG1285	pathogenesis
AOT14_20700	COG0531	amino acid
AOT14_20720	COG3485	protocatechuate 3,4-dioxygenase
AOT14_20770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AOT14_20770	COG0140	phosphoribosyl-ATP diphosphatase activity
AOT14_20790	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AOT14_20800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AOT14_20810	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AOT14_20810	COG0131	Imidazoleglycerol-phosphate dehydratase
AOT14_20820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AOT14_20830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AOT14_20840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AOT14_20860	COG0124	histidyl-tRNA synthetase
AOT14_20870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOT14_20890	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AOT14_20950	COG1012	belongs to the aldehyde dehydrogenase family
AOT14_20980	COG0167	dihydroorotate dehydrogenase activity
AOT14_20990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AOT14_21100	COG3451	type IV secretory pathway VirB4
AOT14_21120	COG3838	Conjugal transfer protein Trbc
AOT14_21130	COG4962	Type ii secretion system protein e
AOT14_21170	COG0583	DNA-binding transcription factor activity
AOT14_21200	COG0589	response to stress
AOT14_21210	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_21240	COG1309	transcriptional regulator
AOT14_21270	COG1131	(ABC) transporter
AOT14_21280	COG0842	Transport permease protein
AOT14_21290	COG0842	Transport permease protein
AOT14_21320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AOT14_21330	COG1611	Belongs to the LOG family
AOT14_21370	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AOT14_21390	COG4959	Type IV secretory pathway protease TraF
AOT14_21420	COG1192	Involved in chromosome partitioning
AOT14_21430	COG3039	Transposase
AOT14_21510	COG5489	Protein of unknown function (DUF736)
AOT14_21590	COG2003	Belongs to the UPF0758 family
AOT14_21620	COG0582	viral genome integration into host DNA
AOT14_21630	COG0519	Catalyzes the synthesis of GMP from XMP
AOT14_21630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AOT14_21660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AOT14_21670	COG1160	GTP binding
AOT14_21680	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOT14_21700	COG1426	Protein conserved in bacteria
AOT14_21720	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AOT14_21730	COG0105	UTP biosynthetic process
AOT14_21750	COG1024	Enoyl-CoA hydratase
AOT14_21750	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOT14_21760	COG0183	Belongs to the thiolase family
AOT14_21790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AOT14_21800	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AOT14_21820	COG0776	regulation of translation
AOT14_21840	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AOT14_21850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AOT14_21870	COG2957	Belongs to the agmatine deiminase family
AOT14_21880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOT14_21930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT14_21990	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AOT14_21990	COG0316	Belongs to the HesB IscA family
AOT14_22000	COG2154	pterin-4-alpha-carbinolamine dehydratase
AOT14_22030	COG1530	ribonuclease E activity
AOT14_22050	COG0671	phosphoesterase, PA-phosphatase related
AOT14_22060	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AOT14_22080	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AOT14_22090	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_22150	COG0305	Participates in initiation and elongation during chromosome replication
AOT14_22170	COG0367	asparagine synthase
AOT14_22180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AOT14_22190	COG0625	glutathione transferase activity
AOT14_22220	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AOT14_22230	COG0590	tRNA wobble adenosine to inosine editing
AOT14_22260	COG0583	DNA-binding transcription factor activity
AOT14_22270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AOT14_22310	COG0077	Prephenate dehydratase
AOT14_22310	COG1605	Chorismate mutase
AOT14_22320	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AOT14_22410	COG0166	Belongs to the GPI family
AOT14_22420	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AOT14_22430	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AOT14_22440	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AOT14_22460	COG0617	tRNA 3'-terminal CCA addition
AOT14_22480	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AOT14_22500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOT14_22520	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AOT14_22530	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AOT14_22570	COG0351	phosphomethylpyrimidine kinase
AOT14_22660	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AOT14_22700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AOT14_22710	COG0360	Binds together with S18 to 16S ribosomal RNA
AOT14_22720	COG0316	Belongs to the HesB IscA family
AOT14_22730	COG0017	Asparaginyl-tRNA synthetase
AOT14_22760	COG2808	Putative FMN-binding domain
AOT14_22770	COG0288	reversible hydration of carbon dioxide
AOT14_22790	COG3844	kynureninase activity
AOT14_22800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT14_22810	COG2925	Exonuclease
AOT14_22870	COG1278	Cold shock
AOT14_22910	COG2902	Dehydrogenase
AOT14_22930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_22940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT14_22980	COG2826	transposase and inactivated derivatives, IS30 family
AOT14_22990	COG2963	transposase activity
AOT14_23000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_23010	COG1960	acyl-CoA dehydrogenase activity
AOT14_23020	COG2226	methyltransferase
AOT14_23060	COG0583	DNA-binding transcription factor activity
AOT14_23070	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AOT14_23080	COG2814	Major facilitator Superfamily
AOT14_23130	COG0386	Belongs to the glutathione peroxidase family
AOT14_23150	COG1725	Transcriptional regulator
AOT14_23160	COG1131	(ABC) transporter
AOT14_23230	COG0840	transmembrane signaling receptor activity
AOT14_23260	COG2850	peptidyl-arginine hydroxylation
AOT14_23280	COG0567	Dehydrogenase, E1 component
AOT14_23300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOT14_23330	COG1595	DNA-templated transcription, initiation
AOT14_23360	COG1132	(ABC) transporter
AOT14_23390	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AOT14_23400	COG0484	heat shock protein binding
AOT14_23410	COG0443	Heat shock 70 kDa protein
AOT14_23420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AOT14_23430	COG0497	DNA recombination
AOT14_23450	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOT14_23480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AOT14_23530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AOT14_23540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOT14_23570	COG0583	DNA-binding transcription factor activity
AOT14_23580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOT14_23670	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AOT14_23680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AOT14_23690	COG2137	regulation of response to DNA damage stimulus
AOT14_23700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AOT14_23720	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOT14_23730	COG1546	Belongs to the CinA family
AOT14_23750	COG0433	COG0433 Predicted ATPase
AOT14_23760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOT14_23780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AOT14_23790	COG0412	Dienelactone hydrolase
AOT14_23820	COG0717	Belongs to the dCTP deaminase family
AOT14_23830	COG0489	protein tyrosine kinase activity
AOT14_23840	COG4771	TonB-dependent receptor
AOT14_23850	COG0457	Tetratricopeptide repeat
AOT14_23870	COG3590	peptidase
AOT14_23900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AOT14_23910	COG0697	spore germination
AOT14_23930	COG2311	Membrane
AOT14_23940	COG1047	Peptidyl-prolyl cis-trans
AOT14_23950	COG0791	NLP P60 protein
AOT14_23960	COG0791	NLP P60 protein
AOT14_23970	COG0612	Peptidase, M16
AOT14_23980	COG0612	Peptidase, M16
AOT14_23990	COG1301	dicarboxylic acid transport
AOT14_24010	COG0037	tRNA processing
AOT14_24020	COG1722	exodeoxyribonuclease VII activity
AOT14_24030	COG0142	geranyltranstransferase activity
AOT14_24050	COG0312	modulator of DNA gyrase
AOT14_24060	COG3028	Belongs to the UPF0307 family
AOT14_24080	COG0312	modulator of DNA gyrase
AOT14_24100	COG1530	ribonuclease E activity
AOT14_24110	COG0424	maF-like protein
AOT14_24120	COG2968	Membrane
AOT14_24160	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AOT14_24180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AOT14_24210	COG0495	leucyl-tRNA aminoacylation
AOT14_24280	COG4251	negative regulation of phosphorylation
AOT14_24280	COG5001	Diguanylate cyclase
AOT14_24280	COG2203	Gaf domain
AOT14_24280	COG3706	GGDEF domain
AOT14_24330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AOT14_24340	COG0346	lactoylglutathione lyase activity
AOT14_24350	COG1131	(ABC) transporter
AOT14_24380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOT14_24380	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOT14_24400	COG2878	Part of a membrane complex involved in electron transport
AOT14_24430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AOT14_24430	COG0116	Belongs to the methyltransferase superfamily
AOT14_24470	COG0494	nUDIX hydrolase
AOT14_24490	COG1024	Enoyl-CoA hydratase
AOT14_24510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AOT14_24530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AOT14_24540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AOT14_24550	COG0573	inorganic phosphate transmembrane transporter activity
AOT14_24560	COG0581	inorganic phosphate transmembrane transporter activity
AOT14_24580	COG0704	Plays a role in the regulation of phosphate uptake
AOT14_24590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOT14_24600	COG0557	exoribonuclease II activity
AOT14_24640	COG2814	Major facilitator Superfamily
AOT14_24650	COG1566	PFAM secretion protein HlyD family protein
AOT14_24740	COG0367	asparagine synthase
AOT14_24750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AOT14_24760	COG1393	Belongs to the ArsC family
AOT14_24780	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AOT14_24790	COG0024	Methionine aminopeptidase
AOT14_24800	COG0052	Belongs to the universal ribosomal protein uS2 family
AOT14_24810	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AOT14_24820	COG3706	GGDEF domain
AOT14_24830	COG0528	UMP kinase activity
AOT14_24850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AOT14_24860	COG0575	Belongs to the CDS family
AOT14_24870	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AOT14_24880	COG0750	zinc metalloprotease
AOT14_24890	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOT14_24900	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT14_24920	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT14_24960	COG0825	malonyl-CoA metabolic process
AOT14_25030	COG0697	spore germination
AOT14_25100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOT14_25190	COG1132	(ABC) transporter
AOT14_25210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AOT14_25250	COG3706	GGDEF domain
AOT14_25250	COG0745	RESPONSE REGULATOR receiver
AOT14_25260	COG1187	pseudouridine synthase activity
AOT14_25270	COG0745	RESPONSE REGULATOR receiver
AOT14_25270	COG3706	GGDEF domain
AOT14_25300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT14_25430	COG0735	belongs to the Fur family
AOT14_25440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOT14_25460	COG1024	Enoyl-CoA hydratase
AOT14_25460	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOT14_25470	COG1946	Acyl-CoA thioesterase
AOT14_25490	COG1595	DNA-templated transcription, initiation
AOT14_25510	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AOT14_25530	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AOT14_25580	COG1073	alpha beta
AOT14_25610	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AOT14_25640	COG2197	response regulator
AOT14_25650	COG4585	Histidine kinase
AOT14_25670	COG0850	regulation of cytokinetic process
AOT14_25680	COG2894	cell division
AOT14_25690	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AOT14_25710	COG2205	protein histidine kinase activity
AOT14_25730	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AOT14_25750	COG2194	sulfuric ester hydrolase activity
AOT14_25800	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AOT14_25860	COG2814	Major facilitator Superfamily
AOT14_25880	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AOT14_25880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AOT14_25910	COG2207	Transcriptional regulator
AOT14_25910	COG1917	Cupin 2, conserved barrel domain protein
AOT14_25940	COG1846	Transcriptional regulator
AOT14_26060	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AOT14_26080	COG0330	HflC and HflK could
AOT14_26090	COG0330	HflC and HflK could
AOT14_26100	COG0604	alcohol dehydrogenase
AOT14_26140	COG0678	peroxiredoxin activity
AOT14_26160	COG4953	penicillin-binding protein 1C
AOT14_26170	COG2373	Large extracellular alpha-helical protein
AOT14_26230	COG0372	Belongs to the citrate synthase family
AOT14_26300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AOT14_26340	COG2814	Major facilitator Superfamily
AOT14_26370	COG3038	cytochrome b561
AOT14_26410	COG1760	l-serine dehydratase
AOT14_26420	COG2199	diguanylate cyclase activity
AOT14_26440	COG0460	homoserine dehydrogenase
AOT14_26440	COG0527	aspartate kinase activity
AOT14_26450	COG0626	cystathionine gamma-synthase activity
AOT14_26460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOT14_26480	COG0739	heme binding
AOT14_26490	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AOT14_26500	COG1272	protein, Hemolysin III
AOT14_26510	COG2982	Protein involved in outer membrane biogenesis
AOT14_26530	COG0463	Glycosyl transferase, family 2
AOT14_26540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AOT14_26550	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AOT14_26600	COG1960	acyl-CoA dehydrogenase activity
AOT14_26680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AOT14_26700	COG0330	HflC and HflK could
AOT14_26720	COG1742	UPF0060 membrane protein
AOT14_26730	COG3956	TIGRFAM MazG family protein
AOT14_26740	COG1218	3'(2'),5'-bisphosphate nucleotidase
AOT14_26750	COG0494	nUDIX hydrolase
AOT14_26760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AOT14_26800	COG0840	transmembrane signaling receptor activity
AOT14_26810	COG0835	chemotaxis
AOT14_26840	COG0189	ligase activity
AOT14_26900	COG1764	response to oxidative stress
AOT14_26950	COG1959	2 iron, 2 sulfur cluster binding
AOT14_26960	COG0719	Fe-S assembly protein
AOT14_26980	COG0396	ATPase activity
AOT14_26990	COG0719	Fe-S assembly protein
AOT14_27000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AOT14_27030	COG4774	siderophore transport
AOT14_27050	COG3128	pkhd-type hydroxylase
AOT14_27070	COG4771	TonB-dependent receptor
AOT14_27110	COG1477	protein flavinylation
AOT14_27120	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AOT14_27160	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_27220	COG0640	Transcriptional regulator
AOT14_27250	COG2205	protein histidine kinase activity
AOT14_27260	COG4771	TonB-dependent receptor
AOT14_27270	COG2610	gluconate transmembrane transporter activity
AOT14_27280	COG1555	photosystem II stabilization
AOT14_27310	COG3178	'Phosphotransferase
AOT14_27320	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AOT14_27330	COG0628	permease
AOT14_27350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AOT14_27380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AOT14_27410	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AOT14_27420	COG0045	succinate-CoA ligase (ADP-forming) activity
AOT14_27450	COG4191	Histidine kinase
AOT14_27460	COG5001	Diguanylate cyclase
AOT14_27480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AOT14_27520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AOT14_27530	COG0673	inositol 2-dehydrogenase activity
AOT14_27560	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AOT14_27600	COG1459	type II secretion system
AOT14_27610	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AOT14_27640	COG0745	RESPONSE REGULATOR receiver
AOT14_27660	COG0189	ligase activity
AOT14_27700	COG2022	thiamine diphosphate biosynthetic process
AOT14_27720	COG3273	potassium ion transport
AOT14_27720	COG0471	metal ion transport
AOT14_27780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOT14_27780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AOT14_27790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOT14_27800	COG1115	amino acid carrier protein
AOT14_27820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT14_27830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_27840	COG2895	sulfate adenylyltransferase (ATP) activity
AOT14_27840	COG0529	Catalyzes the synthesis of activated sulfate
AOT14_27860	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AOT14_27870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOT14_27880	COG0175	sulfate reduction
AOT14_27920	COG0583	DNA-binding transcription factor activity
AOT14_27950	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AOT14_27960	COG3588	fructose-bisphosphate aldolase
AOT14_27970	COG0469	pyruvate kinase activity
AOT14_27990	COG0126	phosphoglycerate kinase activity
AOT14_28000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AOT14_28030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AOT14_28090	COG0427	acetyl-CoA hydrolase
AOT14_28130	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AOT14_28140	COG1301	dicarboxylic acid transport
AOT14_28200	COG0714	Associated with various cellular activities
AOT14_28260	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AOT14_28290	COG0254	rRNA binding
AOT14_28310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AOT14_28330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOT14_28340	COG1758	RNA polymerase activity
AOT14_28350	COG0194	GDP metabolic process
AOT14_28370	COG1561	YicC-like family, N-terminal region
AOT14_28380	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AOT14_28390	COG0346	lactoylglutathione lyase activity
AOT14_28410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AOT14_28440	COG0006	proline dipeptidase activity
AOT14_28460	COG0006	proline dipeptidase activity
AOT14_28470	COG3079	Belongs to the UPF0149 family
AOT14_28510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AOT14_28530	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AOT14_28580	COG2912	Transglutaminase-like superfamily
AOT14_28600	COG0352	thiamine-phosphate diphosphorylase activity
AOT14_28620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AOT14_28640	COG0537	adenosine 5'-monophosphoramidase activity
AOT14_28650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AOT14_28660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOT14_28670	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_28700	COG0671	phosphoesterase, PA-phosphatase related
AOT14_28720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AOT14_28740	COG0563	adenylate kinase activity
AOT14_28790	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AOT14_28800	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AOT14_28850	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AOT14_28870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOT14_28880	COG0405	Gamma-glutamyltransferase
AOT14_28970	COG3409	Peptidoglycan-binding domain 1 protein
AOT14_28970	COG3267	Type II secretory pathway component ExeA
AOT14_29050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AOT14_29090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AOT14_29120	COG0473	3-isopropylmalate dehydrogenase activity
AOT14_29130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AOT14_29170	COG2963	transposase activity
AOT14_29180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AOT14_29240	COG3634	alkyl hydroperoxide reductase activity
AOT14_29250	COG0583	DNA-binding transcription factor activity
AOT14_29260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOT14_29290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOT14_29320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOT14_29340	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AOT14_29380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AOT14_29390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT14_29400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT14_29410	COG2096	Adenosyltransferase
AOT14_29430	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AOT14_29440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOT14_29450	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AOT14_29460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AOT14_29470	COG2967	ApaG domain
AOT14_29480	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AOT14_29510	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AOT14_29520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AOT14_29560	COG0861	Integral membrane protein TerC family
AOT14_29570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AOT14_29580	COG0642	Histidine kinase
AOT14_29620	COG4771	TonB-dependent receptor
AOT14_29640	COG0667	Aldo Keto reductase
AOT14_29650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AOT14_29670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AOT14_29720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_29760	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AOT14_29770	COG1607	acyl-coa hydrolase
AOT14_29780	COG2815	serine threonine protein kinase
AOT14_29780	COG0515	serine threonine protein kinase
AOT14_29790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AOT14_29810	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AOT14_29830	COG0456	acetyltransferase
AOT14_29860	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AOT14_29880	COG0494	nUDIX hydrolase
AOT14_29890	COG0653	protein targeting
AOT14_29900	COG0739	heme binding
AOT14_29920	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AOT14_29940	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AOT14_29960	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AOT14_30010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AOT14_30040	COG3116	cell division
AOT14_30050	COG0275	rRNA processing
AOT14_30060	COG2001	Belongs to the MraZ family
AOT14_30110	COG0792	nuclease activity
AOT14_30120	COG1988	membrane-bound metal-dependent
AOT14_30130	COG0277	FAD linked oxidase domain protein
AOT14_30150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AOT14_30160	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AOT14_30190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOT14_30190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOT14_30210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AOT14_30220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AOT14_30240	COG0488	(ABC) transporter
AOT14_30250	COG2252	PERMEase
AOT14_30270	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AOT14_30280	COG0457	Tetratricopeptide repeat
AOT14_30280	COG3118	belongs to the thioredoxin family
AOT14_30290	COG1215	transferase activity, transferring glycosyl groups
AOT14_30300	COG1215	transferase activity, transferring glycosyl groups
AOT14_30330	COG2194	sulfuric ester hydrolase activity
AOT14_30360	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AOT14_30370	COG0457	Tetratricopeptide repeat
AOT14_30380	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AOT14_30390	COG1215	transferase activity, transferring glycosyl groups
AOT14_30400	COG1215	transferase activity, transferring glycosyl groups
AOT14_30450	COG0047	phosphoribosylformylglycinamidine synthase activity
AOT14_30450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AOT14_30470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOT14_30480	COG4974	Belongs to the 'phage' integrase family
AOT14_30500	COG0795	lipopolysaccharide-transporting ATPase activity
AOT14_30520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AOT14_30570	COG0456	acetyltransferase
AOT14_30590	COG1183	phosphatidylcholine synthase activity
AOT14_30610	COG0442	prolyl-tRNA aminoacylation
AOT14_30640	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AOT14_30650	COG1127	ABC transporter
AOT14_30660	COG3218	ABC-type transport auxiliary lipoprotein component
AOT14_30660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AOT14_30690	COG0024	Methionine aminopeptidase
AOT14_30720	COG3214	Protein conserved in bacteria
AOT14_30780	COG4206	TonB-dependent receptor
AOT14_30860	COG3550	peptidyl-serine autophosphorylation
AOT14_30880	COG3039	Transposase
AOT14_30980	COG2375	cellular response to nickel ion
AOT14_31020	COG0778	Nitroreductase
AOT14_31070	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AOT14_31140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AOT14_31160	COG0459	protein refolding
AOT14_31170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AOT14_31180	COG1324	tolerance protein
AOT14_31200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AOT14_31210	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AOT14_31220	COG0511	ligase activity, forming carbon-carbon bonds
AOT14_31230	COG0439	Biotin carboxylase
AOT14_31240	COG2264	protein methyltransferase activity
AOT14_31260	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AOT14_31270	COG0138	bifunctional purine biosynthesis protein purh
AOT14_31300	COG0151	Belongs to the GarS family
AOT14_31310	COG0667	Aldo Keto reductase
AOT14_31330	COG1289	transmembrane transporter activity
AOT14_31340	COG2814	Major facilitator Superfamily
AOT14_31360	COG2814	Major facilitator Superfamily
AOT14_31400	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AOT14_31470	COG0784	Response regulator, receiver
AOT14_31470	COG2205	protein histidine kinase activity
AOT14_31470	COG5002	protein histidine kinase activity
AOT14_31500	COG1051	belongs to the nudix hydrolase family
AOT14_31540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AOT14_31550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AOT14_31560	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AOT14_31580	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AOT14_31590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOT14_31600	COG0730	response to heat
AOT14_31620	COG0134	indole-3-glycerol-phosphate synthase activity
AOT14_31630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AOT14_31650	COG0512	Glutamine amidotransferase of anthranilate synthase
AOT14_31660	COG3039	Transposase
AOT14_31690	COG1192	Involved in chromosome partitioning
AOT14_31760	COG0629	single-stranded DNA binding
AOT14_31770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AOT14_32190	COG2003	Belongs to the UPF0758 family
AOT14_32360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_32370	COG0842	Transport permease protein
AOT14_32370	COG1129	ABC transporter
AOT14_32380	COG0842	Transport permease protein
AOT14_32400	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_32440	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AOT14_32450	COG0786	glutamate:sodium symporter activity
AOT14_32460	COG3243	poly(R)-hydroxyalkanoic acid synthase
AOT14_32470	COG0589	response to stress
AOT14_32510	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AOT14_32520	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AOT14_32530	COG0583	DNA-binding transcription factor activity
AOT14_32550	COG0582	viral genome integration into host DNA
AOT14_32580	COG2205	protein histidine kinase activity
AOT14_32630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AOT14_32640	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AOT14_32650	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AOT14_32680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AOT14_32680	COG2111	Na H antiporter
AOT14_32690	COG1006	Multisubunit Na H antiporter MnhC subunit
AOT14_32700	COG0651	ATP synthesis coupled electron transport
AOT14_32720	COG2212	antiporter activity
AOT14_32730	COG1320	monovalent cation:proton antiporter activity
AOT14_32800	COG3104	oligopeptide transport
AOT14_32810	COG3483	tryptophan 2,3-dioxygenase activity
AOT14_32820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AOT14_32850	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOT14_32900	COG0702	epimerase
AOT14_32910	COG3706	GGDEF domain
AOT14_32920	COG0612	Peptidase, M16
AOT14_32950	COG2354	Protein conserved in bacteria
AOT14_32970	COG1368	sulfuric ester hydrolase activity
AOT14_32980	COG1196	nuclear chromosome segregation
AOT14_32980	COG3264	Mechanosensitive ion channel
AOT14_33010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AOT14_33040	COG4807	Protein conserved in bacteria
AOT14_33060	COG0789	Transcriptional regulator
AOT14_33170	COG0596	Alpha beta hydrolase
AOT14_33230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOT14_33270	COG0628	permease
AOT14_33290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AOT14_33300	COG0753	catalase activity
AOT14_33320	COG2197	response regulator
AOT14_33330	COG4585	Histidine kinase
AOT14_33340	COG0842	Transport permease protein
AOT14_33350	COG1131	(ABC) transporter
AOT14_33360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_33370	COG1136	(ABC) transporter
AOT14_33390	COG1136	(ABC) transporter
AOT14_33390	COG0577	efflux transmembrane transporter activity
AOT14_33420	COG2962	Rard protein
AOT14_33430	COG0697	spore germination
AOT14_33470	COG0180	Tryptophanyl-tRNA synthetase
AOT14_33490	COG3237	CsbD-like
AOT14_33520	COG0010	Belongs to the arginase family
AOT14_33640	COG3038	cytochrome b561
AOT14_33660	COG4251	negative regulation of phosphorylation
AOT14_33660	COG5001	Diguanylate cyclase
AOT14_33660	COG3706	GGDEF domain
AOT14_33660	COG2203	Gaf domain
AOT14_33680	COG4774	siderophore transport
AOT14_33710	COG3655	Transcriptional regulator
AOT14_33720	COG1506	peptidase
AOT14_33730	COG2205	protein histidine kinase activity
AOT14_33730	COG0784	Response regulator, receiver
AOT14_33750	COG0784	Response regulator, receiver
AOT14_33750	COG2205	protein histidine kinase activity
AOT14_33760	COG2197	response regulator
AOT14_33800	COG4695	Portal protein
AOT14_34300	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AOT14_34310	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AOT14_34310	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AOT14_34340	COG2205	protein histidine kinase activity
AOT14_34350	COG0745	RESPONSE REGULATOR receiver
AOT14_34370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AOT14_34380	COG3209	COG3209 Rhs family protein
AOT14_34400	COG2076	Multidrug Resistance protein
AOT14_34500	COG1285	pathogenesis
AOT14_34510	COG1335	isochorismatase
AOT14_34530	COG1902	pentaerythritol trinitrate reductase activity
AOT14_34560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AOT14_34620	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AOT14_34640	COG0697	spore germination
AOT14_34690	COG1960	acyl-CoA dehydrogenase activity
AOT14_34700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AOT14_34750	COG5001	Diguanylate cyclase
AOT14_34770	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AOT14_34780	COG0583	DNA-binding transcription factor activity
AOT14_34800	COG0277	FAD linked oxidase domain protein
AOT14_34810	COG1304	FMN binding
AOT14_34820	COG2186	Transcriptional regulator
AOT14_34840	COG3279	Response regulator of the LytR AlgR family
AOT14_34870	COG0681	Belongs to the peptidase S26 family
AOT14_34900	COG0339	signal peptide processing
AOT14_34910	COG0415	Belongs to the DNA photolyase family
AOT14_34990	COG3039	Transposase
AOT14_35020	COG0564	pseudouridine synthase activity
AOT14_35060	COG1181	Belongs to the D-alanine--D-alanine ligase family
AOT14_35090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AOT14_35100	COG0318	PFAM AMP-dependent synthetase and ligase
AOT14_35120	COG0596	Alpha beta hydrolase
AOT14_35130	COG1573	uracil-dna glycosylase
AOT14_35140	COG3012	SEC-C Motif Domain Protein
AOT14_35140	COG3318	Belongs to the UPF0149 family
AOT14_35150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AOT14_35170	COG0612	Peptidase, M16
AOT14_35190	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AOT14_35210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOT14_35220	COG1960	acyl-CoA dehydrogenase activity
AOT14_35230	COG1113	amino acid transport
AOT14_35250	COG1199	ATP-dependent helicase activity
AOT14_35270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AOT14_35310	COG3781	membrane
AOT14_35390	COG3039	Transposase
AOT14_35420	COG0625	glutathione transferase activity
AOT14_35450	COG1668	transmembrane transport
AOT14_35460	COG4555	ABC transporter
AOT14_35510	COG3706	GGDEF domain
AOT14_35510	COG0745	RESPONSE REGULATOR receiver
AOT14_35530	COG1131	(ABC) transporter
AOT14_35540	COG0842	Transport permease protein
AOT14_35550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AOT14_35580	COG0084	hydrolase, TatD family'
AOT14_35590	COG1643	Atp-dependent helicase
AOT14_35610	COG1187	pseudouridine synthase activity
AOT14_35670	COG2239	Acts as a magnesium transporter
AOT14_35680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AOT14_35680	COG0475	glutathione-regulated potassium exporter activity
AOT14_35710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AOT14_35730	COG0463	Glycosyl transferase, family 2
AOT14_35740	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_35750	COG2365	Tyrosine phosphatase family
AOT14_35760	COG4771	TonB-dependent receptor
AOT14_35820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AOT14_35850	COG0251	oxidation-reduction process
AOT14_35900	COG0408	coproporphyrinogen oxidase activity
AOT14_35910	COG2323	membrane
AOT14_35950	COG0589	response to stress
AOT14_35960	COG0210	DNA helicase
AOT14_35980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AOT14_35990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AOT14_36080	COG4771	TonB-dependent receptor
AOT14_36090	COG1429	ligase activity, forming nitrogen-metal bonds
AOT14_36130	COG0463	Glycosyl transferase, family 2
AOT14_36160	COG1475	DNA binding
AOT14_36170	COG1192	Involved in chromosome partitioning
AOT14_36180	COG0357	Ribosomal RNA small subunit methyltransferase G
AOT14_36190	COG2091	lysine biosynthetic process via aminoadipic acid
AOT14_36220	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AOT14_36240	COG0725	ABC transporter, periplasmic molybdate-binding protein
AOT14_36260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOT14_36270	COG2181	nitrate reductase activity
AOT14_36280	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AOT14_36290	COG1140	nitrate reductase beta subunit
AOT14_36300	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AOT14_36310	COG2223	nitrite transmembrane transporter activity
AOT14_36330	COG0746	molybdenum cofactor guanylyltransferase activity
AOT14_36340	COG0314	molybdopterin synthase activity
AOT14_36360	COG0303	'Molybdopterin
AOT14_36370	COG0315	cyclic pyranopterin monophosphate synthase activity
AOT14_36370	COG0521	Mo-molybdopterin cofactor biosynthetic process
AOT14_36380	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AOT14_36420	COG4771	TonB-dependent receptor
AOT14_36450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AOT14_36460	COG1120	ATPase activity
AOT14_36470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AOT14_36490	COG3162	membrane
AOT14_36530	COG0840	transmembrane signaling receptor activity
AOT14_36540	COG1971	Probably functions as a manganese efflux pump
AOT14_36610	COG0745	RESPONSE REGULATOR receiver
AOT14_36620	COG0745	RESPONSE REGULATOR receiver
AOT14_36660	COG0729	surface antigen
AOT14_36700	COG0752	glycyl-tRNA synthetase alpha subunit
AOT14_36720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AOT14_36720	COG0519	Catalyzes the synthesis of GMP from XMP
AOT14_36740	COG0805	protein transport
AOT14_36780	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AOT14_36790	COG2267	carboxylic ester hydrolase activity
AOT14_36810	COG2974	May be involved in recombination
AOT14_36820	COG0037	tRNA processing
AOT14_36870	COG2937	Belongs to the GPAT DAPAT family
AOT14_36890	COG0284	orotidine-5'-phosphate decarboxylase activity
AOT14_36900	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AOT14_36910	COG3132	Protein of unknown function, DUF480
AOT14_36920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AOT14_36930	COG0210	DNA helicase
AOT14_36960	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AOT14_36970	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AOT14_37030	COG0840	transmembrane signaling receptor activity
AOT14_37060	COG1752	Esterase of the alpha-beta hydrolase superfamily
AOT14_37100	COG1429	ligase activity, forming nitrogen-metal bonds
AOT14_37110	COG4771	TonB-dependent receptor
AOT14_37130	COG3186	Phenylalanine-4-hydroxylase
AOT14_37160	COG2197	response regulator
AOT14_37260	COG1741	Belongs to the pirin family
AOT14_37270	COG0583	DNA-binding transcription factor activity
AOT14_37290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AOT14_37300	COG1074	ATP-dependent DNA helicase activity
AOT14_37310	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AOT14_37320	COG1127	ABC transporter
AOT14_37330	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AOT14_37340	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AOT14_37370	COG2853	Lipoprotein
AOT14_37390	COG0386	Belongs to the glutathione peroxidase family
AOT14_37440	COG0531	amino acid
AOT14_37460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AOT14_37480	COG0861	Integral membrane protein TerC family
AOT14_37500	COG0584	glycerophosphoryl diester phosphodiesterase
AOT14_37540	COG0706	membrane insertase activity
AOT14_37550	COG0594	ribonuclease P activity
AOT14_37560	COG0230	Belongs to the bacterial ribosomal protein bL34 family