locus-tag	class	description
CEP89_00040	COG4555	ABC transporter
CEP89_00055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CEP89_00060	COG0343	queuine tRNA-ribosyltransferase activity
CEP89_00065	COG0301	tRNA thio-modification
CEP89_00070	COG1295	ribonuclease BN
CEP89_00075	COG1322	Protein conserved in bacteria
CEP89_00085	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CEP89_00095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CEP89_00105	COG3118	belongs to the thioredoxin family
CEP89_00155	COG1012	belongs to the aldehyde dehydrogenase family
CEP89_00160	COG1940	carbohydrate kinase activity
CEP89_00165	COG1253	flavin adenine dinucleotide binding
CEP89_00170	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CEP89_00185	COG0149	triose-phosphate isomerase activity
CEP89_00205	COG0058	SHG alpha-glucan phosphorylase activity
CEP89_00215	COG0275	rRNA processing
CEP89_00225	COG0708	Exodeoxyribonuclease III
CEP89_00230	COG2116	formate transmembrane transporter activity
CEP89_00235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CEP89_00250	COG1011	Hydrolase
CEP89_00260	COG0571	ribonuclease III activity
CEP89_00265	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CEP89_00270	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CEP89_00280	COG0217	transcriptional regulatory protein
CEP89_00285	COG0779	Required for maturation of 30S ribosomal subunits
CEP89_00290	COG0195	Participates in both transcription termination and antitermination
CEP89_00300	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CEP89_00305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CEP89_00310	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CEP89_00310	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CEP89_00315	COG0544	peptidyl-prolyl cis-trans isomerase activity
CEP89_00320	COG0740	serine-type endopeptidase activity
CEP89_00325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CEP89_00330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CEP89_00335	COG0196	riboflavin kinase activity
CEP89_00340	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CEP89_00345	COG0728	peptidoglycan biosynthetic process
CEP89_00355	COG0424	maF-like protein
CEP89_00375	COG0481	GTPase activity
CEP89_00385	COG2860	membrane
CEP89_00395	COG0791	NLP P60 protein
CEP89_00400	COG1435	thymidine kinase activity
CEP89_00425	COG1187	pseudouridine synthase activity
CEP89_00440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CEP89_00445	COG0359	binds to the 23S rRNA
CEP89_00450	COG0305	Participates in initiation and elongation during chromosome replication
CEP89_00460	COG0745	RESPONSE REGULATOR receiver
CEP89_00465	COG5002	protein histidine kinase activity
CEP89_00480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CEP89_00480	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CEP89_00495	COG0037	tRNA processing
CEP89_00505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CEP89_00525	COG2239	Acts as a magnesium transporter
CEP89_00535	COG0488	(ABC) transporter
CEP89_00565	COG2391	methyltransferase activity
CEP89_00570	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
CEP89_00580	COG0860	N-Acetylmuramoyl-L-alanine amidase
CEP89_00590	COG1713	HD superfamily hydrolase involved in NAD metabolism
CEP89_00595	COG0557	exoribonuclease II activity
CEP89_00600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CEP89_00610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CEP89_00615	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CEP89_00630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CEP89_00640	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CEP89_00645	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CEP89_00670	COG0577	efflux transmembrane transporter activity
CEP89_00675	COG0577	efflux transmembrane transporter activity
CEP89_00675	COG1136	(ABC) transporter
CEP89_00760	COG1129	ABC transporter
CEP89_00775	COG1132	(ABC) transporter
CEP89_00780	COG1132	(ABC) transporter
CEP89_00790	COG3069	C4-dicarboxylate transmembrane transporter activity
CEP89_00800	COG1105	Belongs to the carbohydrate kinase PfkB family
CEP89_00845	COG4581	dead DEAH box helicase
CEP89_00945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CEP89_00950	COG0436	Aminotransferase
CEP89_00965	COG0632	four-way junction helicase activity
CEP89_00970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CEP89_00975	COG0470	DNA polymerase III
CEP89_00980	COG1077	Cell shape determining protein MreB Mrl
CEP89_00985	COG0215	cysteine-tRNA ligase activity
CEP89_00990	COG1193	negative regulation of DNA recombination
CEP89_01000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CEP89_01005	COG0037	tRNA processing
CEP89_01010	COG2385	sporulation resulting in formation of a cellular spore
CEP89_01020	COG0628	permease
CEP89_01025	COG1464	Belongs to the NlpA lipoprotein family
CEP89_01030	COG2011	ABC-type metal ion transport system permease component
CEP89_01035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CEP89_01045	COG0653	protein targeting
CEP89_01060	COG0142	geranyltranstransferase activity
CEP89_01070	COG0742	ribosomal rna small subunit methyltransferase
CEP89_01075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CEP89_01080	COG2890	protein-(glutamine-N5) methyltransferase activity
CEP89_01085	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CEP89_01090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CEP89_01090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEP89_01090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEP89_01095	COG4946	Tricorn protease homolog
CEP89_01095	COG1506	peptidase
CEP89_01095	COG0823	Involved in the tonB-independent uptake of proteins
CEP89_01100	COG0154	amidase activity
CEP89_01105	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CEP89_01150	COG1519	Transferase
CEP89_01150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CEP89_01175	COG0765	amino acid transport
CEP89_01180	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CEP89_01185	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CEP89_01205	COG4589	Belongs to the CDS family
CEP89_01210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CEP89_01215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CEP89_01220	COG0756	dUTP diphosphatase activity
CEP89_01230	COG2226	methyltransferase
CEP89_01235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEP89_01275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CEP89_01280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CEP89_01285	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CEP89_01290	COG1732	Glycine betaine
CEP89_01295	COG1125	glycine betaine transport
CEP89_01295	COG0517	IMP dehydrogenase activity
CEP89_01310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CEP89_01325	COG0736	holo-[acyl-carrier-protein] synthase activity
CEP89_01330	COG0084	hydrolase, TatD family'
CEP89_01370	COG1064	alcohol dehydrogenase
CEP89_01375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CEP89_01380	COG0537	adenosine 5'-monophosphoramidase activity
CEP89_01385	COG0698	ribose 5-phosphate isomerase
CEP89_01400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEP89_01415	COG4145	pantothenate transmembrane transporter activity
CEP89_01465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CEP89_01470	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CEP89_01475	COG1780	Probably involved in ribonucleotide reductase function
CEP89_01485	COG0737	Belongs to the 5'-nucleotidase family
CEP89_01510	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CEP89_01515	COG1227	inorganic diphosphatase activity
CEP89_01520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CEP89_01525	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CEP89_01530	COG1480	7TM receptor with intracellular HD hydrolase
CEP89_01535	COG1199	ATP-dependent helicase activity
CEP89_01540	COG0268	Binds directly to 16S ribosomal RNA
CEP89_01545	COG0254	rRNA binding
CEP89_01550	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CEP89_01565	COG0081	regulation of translation
CEP89_01570	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CEP89_01575	COG0250	Participates in transcription elongation, termination and antitermination
CEP89_01590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CEP89_01595	COG3172	ATPase kinase involved in NAD metabolism
CEP89_01600	COG2195	Cleaves the N-terminal amino acid of tripeptides
CEP89_01615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CEP89_01625	COG0295	cytidine deaminase activity
CEP89_01630	COG0813	purine-nucleoside phosphorylase activity
CEP89_01635	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CEP89_01640	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CEP89_01645	COG1744	ABC transporter substrate-binding protein PnrA-like
CEP89_01665	COG0322	excinuclease ABC activity
CEP89_01680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CEP89_01685	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CEP89_01695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CEP89_01700	COG0786	glutamate:sodium symporter activity
CEP89_01705	COG0210	DNA helicase
CEP89_01715	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CEP89_01720	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CEP89_01725	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CEP89_01740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CEP89_01745	COG0358	DNA primase activity
CEP89_01750	COG1758	RNA polymerase activity
CEP89_01755	COG0194	GDP metabolic process
CEP89_01760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CEP89_01765	COG0085	RNA polymerase activity
CEP89_01770	COG0222	ribosome binding
CEP89_01775	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CEP89_01800	COG1116	anion transmembrane transporter activity
CEP89_01810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEP89_01815	COG0583	DNA-binding transcription factor activity
CEP89_01820	COG2252	PERMEase
CEP89_01825	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CEP89_01880	COG0559	Belongs to the binding-protein-dependent transport system permease family
CEP89_01965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CEP89_01970	COG0668	transmembrane transport
CEP89_01975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEP89_01990	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CEP89_02005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CEP89_02020	COG0017	Asparaginyl-tRNA synthetase
CEP89_02050	COG3842	ATPase activity
CEP89_02055	COG3833	ABC-type maltose transport systems, permease component
CEP89_02060	COG1175	transmembrane transport
CEP89_02075	COG1131	(ABC) transporter
CEP89_02095	COG1523	belongs to the glycosyl hydrolase 13 family
CEP89_02105	COG1609	Transcriptional regulator
CEP89_02110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CEP89_02115	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CEP89_02125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CEP89_02130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CEP89_02135	COG0469	pyruvate kinase activity
CEP89_02140	COG0205	6-phosphofructokinase activity
CEP89_02165	COG2190	(PTS) system
CEP89_02175	COG0180	Tryptophanyl-tRNA synthetase
CEP89_02180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CEP89_02185	COG1686	Belongs to the peptidase S11 family
CEP89_02205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CEP89_02210	COG1185	polyribonucleotide nucleotidyltransferase activity
CEP89_02215	COG4804	nuclease activity
CEP89_02235	COG0670	Belongs to the BI1 family
CEP89_02240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CEP89_02265	COG1177	transmembrane transport
CEP89_02270	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEP89_02275	COG3842	ATPase activity
CEP89_02280	COG1362	aminopeptidase activity
CEP89_02285	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CEP89_02315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CEP89_02330	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CEP89_02335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CEP89_02345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CEP89_02350	COG0768	penicillin binding
CEP89_02355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CEP89_02360	COG0154	amidase activity
CEP89_02365	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CEP89_02380	COG1131	(ABC) transporter
CEP89_02395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CEP89_02410	COG4974	Belongs to the 'phage' integrase family
CEP89_02415	COG3119	arylsulfatase activity
CEP89_02420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CEP89_02425	COG0497	DNA recombination
CEP89_02430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CEP89_02435	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CEP89_02440	COG1132	(ABC) transporter
CEP89_02450	COG0495	leucyl-tRNA aminoacylation
CEP89_02455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CEP89_02460	COG4977	sequence-specific DNA binding
CEP89_02485	COG0203	ribosomal protein L17
CEP89_02490	COG0202	RNA polymerase activity
CEP89_02495	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CEP89_02500	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CEP89_02505	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CEP89_02515	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CEP89_02525	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CEP89_02530	COG0018	arginyl-trna synthetase
CEP89_02535	COG2176	DNA-directed DNA polymerase activity
CEP89_02540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CEP89_02545	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CEP89_02570	COG0442	prolyl-tRNA aminoacylation
CEP89_02580	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CEP89_02585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CEP89_02595	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CEP89_02600	COG4211	Belongs to the binding-protein-dependent transport system permease family
CEP89_02605	COG1129	ABC transporter
CEP89_02610	COG1879	ABC-type sugar transport system periplasmic component
CEP89_02615	COG1940	carbohydrate kinase activity
CEP89_02620	COG0572	uridine kinase
CEP89_02625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEP89_02625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEP89_02625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEP89_02630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CEP89_02635	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CEP89_02640	COG1799	cell septum assembly
CEP89_02665	COG1121	(ABC) transporter
CEP89_02675	COG0658	competence protein
CEP89_02675	COG2333	competence protein COMEC
CEP89_02735	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CEP89_02745	COG1104	cysteine desulfurase activity
CEP89_02750	COG1543	Belongs to the glycosyl hydrolase 57 family
CEP89_02760	COG0681	Belongs to the peptidase S26 family
CEP89_02765	COG1494	fructose-1,6-bisphosphatase
CEP89_02770	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CEP89_02785	COG3210	domain, Protein
CEP89_02790	COG1464	Belongs to the NlpA lipoprotein family
CEP89_02795	COG2011	ABC-type metal ion transport system permease component
CEP89_02805	COG1840	ABC-type Fe3 transport system, periplasmic component
CEP89_02815	COG3842	ATPase activity
CEP89_02840	COG1704	LemA family
CEP89_02845	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CEP89_02850	COG0237	dephospho-CoA kinase activity
CEP89_02865	COG1774	PSP1 C-terminal conserved region
CEP89_02870	COG2003	Belongs to the UPF0758 family
CEP89_02875	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CEP89_02885	COG1263	PTS System
CEP89_02885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEP89_02885	COG2190	(PTS) system
CEP89_02905	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CEP89_02910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEP89_02920	COG3842	ATPase activity
CEP89_02925	COG1394	ATPase activity, coupled to movement of substances
CEP89_02930	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CEP89_02935	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CEP89_02940	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
CEP89_02950	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
CEP89_02955	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CEP89_02960	COG1269	ATP hydrolysis coupled proton transport
CEP89_02970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEP89_02970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEP89_03010	COG1459	type II secretion system
CEP89_03055	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CEP89_03065	COG0525	valine-tRNA ligase activity
CEP89_03110	COG2059	Chromate
CEP89_03120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEP89_03145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CEP89_03150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CEP89_03155	COG1121	(ABC) transporter
CEP89_03160	COG0803	Belongs to the bacterial solute-binding protein 9 family
CEP89_03185	COG1077	Cell shape determining protein MreB Mrl
CEP89_03190	COG0233	cytoplasmic translational termination
CEP89_03195	COG0528	UMP kinase activity
CEP89_03200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CEP89_03205	COG0052	Belongs to the universal ribosomal protein uS2 family
CEP89_03215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEP89_03240	COG4120	Belongs to the binding-protein-dependent transport system permease family
CEP89_03260	COG2723	6-phospho-beta-galactosidase activity
CEP89_03270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CEP89_03275	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CEP89_03285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEP89_03285	COG3711	transcriptional antiterminator
CEP89_03290	COG1115	amino acid carrier protein
CEP89_03295	COG0089	rRNA binding
CEP89_03300	COG0088	Forms part of the polypeptide exit tunnel
CEP89_03305	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CEP89_03310	COG0051	transcription antitermination factor activity, RNA binding
CEP89_03315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CEP89_03320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CEP89_03325	COG0049	tRNA binding
CEP89_03330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CEP89_03335	COG3210	domain, Protein
CEP89_03335	COG3468	outer membrane autotransporter barrel domain protein
CEP89_03345	COG1288	antiporter activity
CEP89_03350	COG0549	Belongs to the carbamate kinase family
CEP89_03355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CEP89_03360	COG2235	arginine
CEP89_03385	COG5295	Hep Hag repeat protein
CEP89_03440	COG1346	cytolysis
CEP89_03445	COG1380	Effector of murein hydrolase LrgA
CEP89_03450	COG2201	protein-glutamate methylesterase activity
CEP89_03455	COG0561	phosphatase activity
CEP89_03460	COG1301	dicarboxylic acid transport
CEP89_03465	COG3210	domain, Protein
CEP89_03465	COG3468	outer membrane autotransporter barrel domain protein
CEP89_03470	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEP89_03475	COG3715	PTS system
CEP89_03480	COG3716	PTS system mannose fructose sorbose family IID component
CEP89_03500	COG2222	sugar isomerase
CEP89_03505	COG5426	von Willebrand factor, type A
CEP89_03515	COG1175	transmembrane transport
CEP89_03520	COG0395	ABC-type sugar transport system, permease component
CEP89_03535	COG3684	Belongs to the aldolase LacD family
CEP89_03550	COG4555	ABC transporter
CEP89_03560	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CEP89_03595	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CEP89_03600	COG3119	arylsulfatase activity
CEP89_03605	COG5492	domain, Protein
CEP89_03615	COG1653	transport
CEP89_03620	COG0395	ABC-type sugar transport system, permease component
CEP89_03625	COG4209	transmembrane transport
CEP89_03630	COG3842	ATPase activity
CEP89_03635	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CEP89_03640	COG1028	Short-chain dehydrogenase reductase Sdr
CEP89_03645	COG5492	domain, Protein
CEP89_03650	COG0800	Aldolase
CEP89_03655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEP89_03660	COG1609	Transcriptional regulator
CEP89_03680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEP89_03680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEP89_03680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEP89_03690	COG1349	DNA-binding transcription factor activity
CEP89_03720	COG2755	lipolytic protein G-D-S-L family
CEP89_03720	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CEP89_03740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CEP89_03750	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CEP89_03755	COG1847	R3H domain protein
CEP89_03760	COG0706	membrane insertase activity
CEP89_03770	COG0594	ribonuclease P activity
CEP89_03785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CEP89_03790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CEP89_03835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CEP89_03840	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CEP89_03850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CEP89_03850	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CEP89_03855	COG0716	FMN binding
CEP89_03865	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CEP89_03880	COG0802	atpase or kinase
CEP89_03905	COG1132	(ABC) transporter
CEP89_03910	COG4166	transmembrane transport
CEP89_03915	COG4608	Belongs to the ABC transporter superfamily
CEP89_03920	COG0444	Belongs to the ABC transporter superfamily
CEP89_03925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEP89_03930	COG0601	transmembrane transport
CEP89_03935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CEP89_03960	COG1523	belongs to the glycosyl hydrolase 13 family
CEP89_03975	COG0151	Belongs to the GarS family
CEP89_03980	COG0138	bifunctional purine biosynthesis protein purh
CEP89_03990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CEP89_03995	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CEP89_04000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CEP89_04010	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CEP89_04015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CEP89_04025	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CEP89_04040	COG2501	S4 domain
CEP89_04045	COG0504	CTP synthase activity
CEP89_04060	COG1940	carbohydrate kinase activity
CEP89_04065	COG1263	PTS System
CEP89_04065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEP89_04065	COG2190	(PTS) system
CEP89_04070	COG0191	fructose-bisphosphate aldolase activity
CEP89_04090	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CEP89_04095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CEP89_04100	COG0772	Belongs to the SEDS family
CEP89_04105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CEP89_04110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CEP89_04115	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CEP89_04120	COG0488	(ABC) transporter
CEP89_04130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CEP89_04160	COG1131	(ABC) transporter
CEP89_04165	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CEP89_04170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CEP89_04195	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CEP89_04205	COG3210	domain, Protein
CEP89_04225	COG1114	Component of the transport system for branched-chain amino acids
CEP89_04230	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CEP89_04250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CEP89_04260	COG2848	UPF0210 protein
CEP89_04290	COG0745	RESPONSE REGULATOR receiver
CEP89_04335	COG0360	Binds together with S18 to 16S ribosomal RNA
CEP89_04345	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CEP89_04365	COG0587	DNA-directed DNA polymerase activity
CEP89_04380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEP89_04390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CEP89_04395	COG1126	abc transporter atp-binding protein
CEP89_04400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEP89_04405	COG0601	transmembrane transport
CEP89_04415	COG1114	Component of the transport system for branched-chain amino acids
CEP89_04465	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CEP89_04470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CEP89_04480	COG1022	Amp-dependent synthetase and ligase
CEP89_04485	COG0228	four-way junction DNA binding
CEP89_04490	COG0561	phosphatase activity
CEP89_04500	COG0101	tRNA pseudouridine synthase activity
CEP89_04510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CEP89_04525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CEP89_04530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CEP89_04570	COG0616	signal peptide processing
CEP89_04585	COG0564	pseudouridine synthase activity
CEP89_04590	COG1461	Dihydroxyacetone kinase
CEP89_04595	COG0539	negative regulation of cytoplasmic translation
CEP89_04595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CEP89_04605	COG1051	belongs to the nudix hydrolase family
CEP89_04615	COG0785	Cytochrome C biogenesis protein
CEP89_04620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEP89_04630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CEP89_04630	COG0519	Catalyzes the synthesis of GMP from XMP
CEP89_04680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEP89_04705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CEP89_04735	COG3775	system Galactitol-specific IIC component
CEP89_04745	COG1132	(ABC) transporter
CEP89_04775	COG1902	pentaerythritol trinitrate reductase activity
CEP89_04780	COG1323	Belongs to the UPF0348 family
CEP89_04795	COG1136	(ABC) transporter
CEP89_04810	COG2197	response regulator
CEP89_04815	COG2211	Major facilitator Superfamily
CEP89_04820	COG3959	Transketolase, thiamine diphosphate binding domain
CEP89_04825	COG3958	Transketolase
CEP89_04840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEP89_04845	COG4797	methyltransferase
CEP89_04845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CEP89_04865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CEP89_04880	COG1077	Cell shape determining protein MreB Mrl
CEP89_04885	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CEP89_04890	COG1187	pseudouridine synthase activity
CEP89_04915	COG0542	response to heat
CEP89_04920	COG1420	regulation of RNA biosynthetic process
CEP89_04925	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CEP89_04930	COG0443	Heat shock 70 kDa protein
CEP89_04940	COG0484	heat shock protein binding
CEP89_04950	COG3711	transcriptional antiterminator
CEP89_04955	COG1263	PTS System
CEP89_04955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEP89_04955	COG2190	(PTS) system
CEP89_04965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEP89_04975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEP89_04985	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CEP89_05000	COG0563	adenylate kinase activity
CEP89_05015	COG5295	Hep Hag repeat protein
CEP89_05040	COG0366	Alpha amylase catalytic
CEP89_05075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CEP89_05085	COG1482	cell wall glycoprotein biosynthetic process
CEP89_05110	COG1966	Carbon starvation protein
CEP89_05115	COG1966	Carbon starvation protein
CEP89_05125	COG3037	sugar-specific permease SgaT UlaA
CEP89_05135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEP89_05140	COG3623	hexulose-6-phosphate isomerase
CEP89_05145	COG0235	Class ii aldolase
CEP89_05175	COG2826	transposase and inactivated derivatives, IS30 family
CEP89_05200	COG3250	beta-galactosidase activity
CEP89_05205	COG2211	Major facilitator Superfamily
CEP89_05215	COG1904	glucuronate isomerase
CEP89_05220	COG1312	Catalyzes the dehydration of D-mannonate
CEP89_05225	COG1028	Short-chain dehydrogenase reductase Sdr
CEP89_05230	COG0640	Transcriptional regulator
CEP89_05250	COG3715	PTS system
CEP89_05255	COG3716	PTS system mannose fructose sorbose family IID component
CEP89_05285	COG0166	Belongs to the GPI family
CEP89_05305	COG3425	synthase
CEP89_05315	COG3579	cysteine-type endopeptidase activity
CEP89_05320	COG0656	L-ascorbic acid biosynthetic process
CEP89_05335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CEP89_05350	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CEP89_05355	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CEP89_05360	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CEP89_05365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CEP89_05370	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CEP89_05375	COG0255	Belongs to the universal ribosomal protein uL29 family
CEP89_05380	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CEP89_05385	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CEP89_05395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CEP89_05400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CEP89_05405	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CEP89_05410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CEP89_05415	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CEP89_05420	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CEP89_05425	COG1841	ribosomal large subunit assembly
CEP89_05430	COG0200	Binds to the 23S rRNA
CEP89_05450	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CEP89_05460	COG0187	DNA topoisomerase II activity
CEP89_05465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CEP89_05485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CEP89_05490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEP89_05490	COG0072	phenylalanine-tRNA ligase activity
CEP89_05515	COG0803	Belongs to the bacterial solute-binding protein 9 family
CEP89_05520	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CEP89_05535	COG2217	Heavy metal translocating P-type atpase
CEP89_05585	COG1328	CTP reductase activity
CEP89_05585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CEP89_05600	COG0778	Nitroreductase
CEP89_05625	COG1266	CAAX protease self-immunity
CEP89_05630	COG0006	proline dipeptidase activity
CEP89_05640	COG1132	(ABC) transporter
CEP89_05645	COG1132	(ABC) transporter
CEP89_05665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CEP89_05670	COG0022	dehydrogenase e1 component
CEP89_05675	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEP89_05680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEP89_05685	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CEP89_05690	COG0095	Lipoate-protein ligase
CEP89_05695	COG1956	GAF domain-containing protein
CEP89_05700	COG4409	exo-alpha-(2->6)-sialidase activity
CEP89_05705	COG0745	RESPONSE REGULATOR receiver
CEP89_05715	COG0363	glucosamine-6-phosphate deaminase activity
CEP89_05730	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CEP89_05735	COG1162	GTPase activity
CEP89_05740	COG0515	serine threonine protein kinase
CEP89_05740	COG2815	serine threonine protein kinase
CEP89_05885	COG4962	Type ii secretion system protein e
CEP89_05915	COG3451	type IV secretory pathway VirB4
CEP89_05970	COG2885	chlorophyll binding
CEP89_05980	COG0791	NLP P60 protein
CEP89_06005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CEP89_06015	COG3700	Belongs to the class B bacterial acid phosphatase family
CEP89_06020	COG3210	domain, Protein
CEP89_06020	COG3064	Membrane
CEP89_06020	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CEP89_06040	COG3210	domain, Protein
CEP89_06085	COG3037	sugar-specific permease SgaT UlaA
CEP89_06090	COG3959	Transketolase, thiamine diphosphate binding domain
CEP89_06095	COG3958	Transketolase
CEP89_06100	COG1131	(ABC) transporter
CEP89_06110	COG0697	spore germination
CEP89_06115	COG0396	ATPase activity
CEP89_06125	COG0719	Fe-S assembly protein
CEP89_06130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CEP89_06185	COG5522	Integral membrane protein (intg_mem_TP0381)
CEP89_06190	COG0445	tRNA wobble uridine modification
CEP89_06205	COG0450	alkyl hydroperoxide reductase
CEP89_06210	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CEP89_06225	COG1164	Oligoendopeptidase f
CEP89_06245	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CEP89_06250	COG2137	regulation of response to DNA damage stimulus
CEP89_06255	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CEP89_06260	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CEP89_06310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CEP89_06320	COG1132	(ABC) transporter
CEP89_06325	COG1132	(ABC) transporter
CEP89_06335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CEP89_06335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CEP89_06340	COG0546	phosphoglycolate phosphatase activity
CEP89_06350	COG0564	pseudouridine synthase activity
CEP89_06365	COG2183	response to ionizing radiation
CEP89_06370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CEP89_06375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CEP89_06380	COG0752	glycyl-tRNA synthetase alpha subunit
CEP89_06385	COG0751	glycine-tRNA ligase activity
CEP89_06395	COG2255	four-way junction helicase activity
CEP89_06410	COG0799	negative regulation of ribosome biogenesis
CEP89_06420	COG0357	Ribosomal RNA small subunit methyltransferase G
CEP89_06440	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CEP89_06450	COG1181	Belongs to the D-alanine--D-alanine ligase family
CEP89_06460	COG1739	Uncharacterized protein family UPF0029
CEP89_06465	COG1160	GTP binding
CEP89_06490	COG0822	iron-sulfur transferase activity
CEP89_06495	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CEP89_06500	COG0124	histidyl-tRNA synthetase
CEP89_06505	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CEP89_06520	COG3468	outer membrane autotransporter barrel domain protein
CEP89_06520	COG3210	domain, Protein
CEP89_06535	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CEP89_06545	COG0588	phosphoglycerate mutase activity
CEP89_06550	COG1882	Formate acetyltransferase
CEP89_06555	COG2195	Cleaves the N-terminal amino acid of tripeptides
CEP89_06570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CEP89_06575	COG0251	oxidation-reduction process
CEP89_06580	COG1454	alcohol dehydrogenase
CEP89_06580	COG1012	belongs to the aldehyde dehydrogenase family
CEP89_06590	COG1737	Transcriptional regulator
CEP89_06595	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CEP89_06605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CEP89_06620	COG0395	ABC-type sugar transport system, permease component
CEP89_06635	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CEP89_06650	COG0863	Belongs to the N(4) N(6)-methyltransferase family
CEP89_06655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CEP89_06670	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CEP89_06705	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CEP89_06730	COG2171	N-acyltransferase activity
CEP89_06740	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CEP89_06750	COG2081	HI0933 family
CEP89_06755	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CEP89_06760	COG0730	response to heat
CEP89_06780	COG1490	D-aminoacyl-tRNA deacylase activity
CEP89_06785	COG0791	NLP P60 protein
CEP89_06795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CEP89_06815	COG0641	radical SAM
CEP89_06825	COG0300	oxidoreductase activity
CEP89_06830	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CEP89_06840	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEP89_06860	COG2342	PFAM TM1410 hypothetical-related protein
CEP89_06865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CEP89_06870	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CEP89_06875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CEP89_06880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CEP89_06890	COG0534	Mate efflux family protein
CEP89_06895	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CEP89_06905	COG0750	zinc metalloprotease
CEP89_06920	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEP89_06920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEP89_06940	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CEP89_06955	COG2233	PERMEase
CEP89_06975	COG1840	ABC-type Fe3 transport system, periplasmic component
CEP89_06985	COG3842	ATPase activity
CEP89_06995	COG1737	Transcriptional regulator
CEP89_07020	COG0148	phosphopyruvate hydratase activity
CEP89_07040	COG0616	signal peptide processing
CEP89_07070	COG2813	Specifically methylates the guanine in position
CEP89_07085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEP89_07090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CEP89_07100	COG0445	tRNA wobble uridine modification
CEP89_07105	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CEP89_07110	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CEP89_07115	COG0516	GMP reductase activity
CEP89_07115	COG0517	IMP dehydrogenase activity
CEP89_07120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CEP89_07140	COG4608	Belongs to the ABC transporter superfamily
CEP89_07145	COG0601	transmembrane transport
CEP89_07150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEP89_07155	COG0006	proline dipeptidase activity
CEP89_07175	COG1418	mRNA catabolic process
CEP89_07180	COG1692	metallophosphoesterase
CEP89_07185	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CEP89_07190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CEP89_07200	COG0612	Peptidase, M16
CEP89_07205	COG0772	Belongs to the SEDS family
CEP89_07210	COG0564	pseudouridine synthase activity
CEP89_07215	COG1278	Cold shock
CEP89_07220	COG0601	transmembrane transport
CEP89_07245	COG1649	PFAM Uncharacterised BCR, COG1649
CEP89_07250	COG0556	nucleotide-excision repair
CEP89_07255	COG1393	Belongs to the ArsC family
CEP89_07260	COG1570	exodeoxyribonuclease VII activity
CEP89_07270	COG1196	nuclear chromosome segregation
CEP89_07290	COG0335	large ribosomal subunit rRNA binding
CEP89_07295	COG4974	Belongs to the 'phage' integrase family
CEP89_07390	COG4962	Type ii secretion system protein e
CEP89_07425	COG3451	type IV secretory pathway VirB4
CEP89_07445	COG3309	Virulence-associated protein D
CEP89_07480	COG2885	chlorophyll binding
CEP89_07490	COG0791	NLP P60 protein
CEP89_07515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CEP89_07580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEP89_07580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CEP89_07585	COG0617	tRNA 3'-terminal CCA addition
CEP89_07590	COG4752	Belongs to the RNA methyltransferase TrmD family
CEP89_07595	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CEP89_07605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CEP89_07610	COG0336	Belongs to the RNA methyltransferase TrmD family
CEP89_07650	COG1792	Involved in formation and maintenance of cell shape
CEP89_07660	COG1381	Involved in DNA repair and RecF pathway recombination
CEP89_07665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEP89_07665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEP89_07665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEP89_07690	COG1136	(ABC) transporter
CEP89_07695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CEP89_07705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CEP89_07715	COG0438	transferase activity, transferring glycosyl groups