locus-tag	class	description
SaSA218_0002	COG0592	DNA-directed DNA polymerase activity
SaSA218_0005	COG0012	GTP binding
SaSA218_0006	COG0193	aminoacyl-tRNA hydrolase activity
SaSA218_0008	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SaSA218_0011	COG0037	tRNA processing
SaSA218_0013	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SaSA218_0021	COG2801	Transposase and inactivated derivatives
SaSA218_0026	COG1695	Transcriptional regulator
SaSA218_0029	COG1755	Isoprenylcysteine carboxyl methyltransferase
SaSA218_0033	COG4224	UPF0291 protein
SaSA218_0036	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SaSA218_0037	COG0446	pyridine nucleotide-disulphide oxidoreductase
SaSA218_0043	COG1131	(ABC) transporter
SaSA218_0045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SaSA218_0045	COG2190	(PTS) system
SaSA218_0045	COG1263	PTS System
SaSA218_0047	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SaSA218_0048	COG0275	rRNA processing
SaSA218_0050	COG0768	penicillin binding
SaSA218_0052	COG0513	Belongs to the DEAD box helicase family
SaSA218_0055	COG1126	abc transporter atp-binding protein
SaSA218_0057	COG0492	ferredoxin-NADP+ reductase activity
SaSA218_0058	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SaSA218_0061	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SaSA218_0063	COG4474	Belongs to the UPF0398 family
SaSA218_0065	COG0116	Belongs to the methyltransferase superfamily
SaSA218_0069	COG1131	(ABC) transporter
SaSA218_0072	COG4585	Histidine kinase
SaSA218_0077	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SaSA218_0079	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SaSA218_0079	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SaSA218_0081	COG0515	serine threonine protein kinase
SaSA218_0081	COG2815	serine threonine protein kinase
SaSA218_0083	COG4585	Histidine kinase
SaSA218_0084	COG2197	response regulator
SaSA218_0086	COG1098	S1 RNA binding domain
SaSA218_0088	COG1349	DNA-binding transcription factor activity
SaSA218_0090	COG1447	Phosphotransferase system cellobiose-specific component IIA
SaSA218_0094	COG1739	Uncharacterized protein family UPF0029
SaSA218_0095	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SaSA218_0096	COG1040	competence protein
SaSA218_0098	COG0527	aspartate kinase activity
SaSA218_0100	COG1024	Enoyl-CoA hydratase
SaSA218_0104	COG2070	2-Nitropropane dioxygenase
SaSA218_0105	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SaSA218_0106	COG1028	Short-chain dehydrogenase reductase Sdr
SaSA218_0107	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SaSA218_0110	COG0439	Biotin carboxylase
SaSA218_0117	COG3716	PTS system mannose fructose sorbose family IID component
SaSA218_0118	COG3715	PTS system
SaSA218_0120	COG0561	phosphatase activity
SaSA218_0123	COG2252	PERMEase
SaSA218_0124	COG0802	atpase or kinase
SaSA218_0126	COG1316	TRANSCRIPTIONal
SaSA218_0128	COG0537	adenosine 5'-monophosphoramidase activity
SaSA218_0130	COG1131	(ABC) transporter
SaSA218_0131	COG4473	ABC transporter
SaSA218_0135	COG0195	Participates in both transcription termination and antitermination
SaSA218_0136	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SaSA218_0144	COG2860	membrane
SaSA218_0146	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SaSA218_0146	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SaSA218_0147	COG1832	CoA-binding protein
SaSA218_0153	COG1268	BioY protein
SaSA218_0154	COG1234	tRNA 3'-trailer cleavage
SaSA218_0157	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SaSA218_0158	COG0705	Rhomboid family
SaSA218_0158	COG0457	Tetratricopeptide repeat
SaSA218_0159	COG1744	ABC transporter substrate-binding protein PnrA-like
SaSA218_0160	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SaSA218_0163	COG0706	membrane insertase activity
SaSA218_0166	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SaSA218_0167	COG0436	Aminotransferase
SaSA218_0168	COG1381	Involved in DNA repair and RecF pathway recombination
SaSA218_0169	COG2801	Transposase and inactivated derivatives
SaSA218_0172	COG0416	fatty acid biosynthetic process
SaSA218_0173	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SaSA218_0174	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SaSA218_0175	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SaSA218_0178	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SaSA218_0185	COG1175	transmembrane transport
SaSA218_0187	COG0395	ABC-type sugar transport system, permease component
SaSA218_0190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SaSA218_0195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SaSA218_0200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SaSA218_0203	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SaSA218_0205	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SaSA218_0205	COG2755	lipolytic protein G-D-S-L family
SaSA218_0206	COG1454	alcohol dehydrogenase
SaSA218_0206	COG1012	belongs to the aldehyde dehydrogenase family
SaSA218_0207	COG1064	alcohol dehydrogenase
SaSA218_0209	COG0534	Mate efflux family protein
SaSA218_0231	COG0201	protein transport
SaSA218_0232	COG0563	adenylate kinase activity
SaSA218_0234	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SaSA218_0237	COG0202	RNA polymerase activity
SaSA218_0241	COG1121	(ABC) transporter
SaSA218_0242	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SaSA218_0244	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SaSA218_0245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SaSA218_0245	COG4499	WXG100 protein secretion system (Wss), protein YukC
SaSA218_0249	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SaSA218_0250	COG1459	type II secretion system
SaSA218_0258	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SaSA218_0259	COG1363	Peptidase, m42
SaSA218_0262	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SaSA218_0263	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SaSA218_0266	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SaSA218_0267	COG3275	phosphorelay sensor kinase activity
SaSA218_0268	COG3279	Response regulator of the LytR AlgR family
SaSA218_0270	COG1346	cytolysis
SaSA218_0272	COG0601	transmembrane transport
SaSA218_0273	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SaSA218_0274	COG1122	ATPase activity
SaSA218_0278	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SaSA218_0281	COG3959	Transketolase, thiamine diphosphate binding domain
SaSA218_0286	COG1045	serine acetyltransferase
SaSA218_0288	COG0215	cysteine-tRNA ligase activity
SaSA218_0289	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SaSA218_0290	COG2801	Transposase and inactivated derivatives
SaSA218_0296	COG1476	TRANSCRIPTIONal
SaSA218_0297	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SaSA218_0305	COG1396	sequence-specific DNA binding
SaSA218_0308	COG1732	Glycine betaine
SaSA218_0318	COG1705	Flagellar rod assembly protein muramidase FlgJ
SaSA218_0323	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SaSA218_0325	COG0351	phosphomethylpyrimidine kinase
SaSA218_0326	COG4720	Psort location CytoplasmicMembrane, score
SaSA218_0327	COG4475	Protein of unknown function (DUF436)
SaSA218_0328	COG0668	transmembrane transport
SaSA218_0333	COG0756	dUTP diphosphatase activity
SaSA218_0336	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SaSA218_0337	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SaSA218_0339	COG1172	Belongs to the binding-protein-dependent transport system permease family
SaSA218_0342	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SaSA218_0343	COG1609	Transcriptional regulator
SaSA218_0344	COG0577	efflux transmembrane transporter activity
SaSA218_0345	COG1136	(ABC) transporter
SaSA218_0347	COG5002	protein histidine kinase activity
SaSA218_0349	COG0165	Argininosuccinate lyase
SaSA218_0350	COG0191	fructose-bisphosphate aldolase activity
SaSA218_0354	COG1461	Dihydroxyacetone kinase
SaSA218_0358	COG1126	abc transporter atp-binding protein
SaSA218_0359	COG0765	amino acid transport
SaSA218_0361	COG1968	undecaprenyl-diphosphatase activity
SaSA218_0362	COG4862	establishment of competence for transformation
SaSA218_0363	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SaSA218_0365	COG0719	Fe-S assembly protein
SaSA218_0366	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SaSA218_0368	COG0719	Fe-S assembly protein
SaSA218_0369	COG1686	Belongs to the peptidase S11 family
SaSA218_0370	COG1686	Belongs to the peptidase S11 family
SaSA218_0371	COG4166	transmembrane transport
SaSA218_0372	COG0601	transmembrane transport
SaSA218_0373	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SaSA218_0374	COG0444	Belongs to the ABC transporter superfamily
SaSA218_0375	COG4608	Belongs to the ABC transporter superfamily
SaSA218_0377	COG2137	regulation of response to DNA damage stimulus
SaSA218_0378	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SaSA218_0380	COG2153	protein acetylation
SaSA218_0382	COG1216	Glycosyl transferase, family 2
SaSA218_0382	COG1442	glycosyl transferase family 8
SaSA218_0392	COG0789	Transcriptional regulator
SaSA218_0393	COG1063	alcohol dehydrogenase
SaSA218_0394	COG0656	L-ascorbic acid biosynthetic process
SaSA218_0400	COG2226	methyltransferase
SaSA218_0402	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SaSA218_0403	COG3414	Phosphotransferase system galactitol-specific IIB component
SaSA218_0404	COG3775	system Galactitol-specific IIC component
SaSA218_0405	COG0235	Class ii aldolase
SaSA218_0407	COG3775	system Galactitol-specific IIC component
SaSA218_0408	COG3414	Phosphotransferase system galactitol-specific IIB component
SaSA218_0409	COG2207	Transcriptional regulator
SaSA218_0412	COG0395	ABC-type sugar transport system, permease component
SaSA218_0414	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SaSA218_0416	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SaSA218_0432	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SaSA218_0433	COG0673	inositol 2-dehydrogenase activity
SaSA218_0435	COG2315	Protein conserved in bacteria
SaSA218_0438	COG0742	ribosomal rna small subunit methyltransferase
SaSA218_0441	COG3480	Lon protease (S16) C-terminal proteolytic domain
SaSA218_0443	COG4470	Protein conserved in bacteria
SaSA218_0446	COG1132	(ABC) transporter
SaSA218_0447	COG1132	(ABC) transporter
SaSA218_0448	COG0512	Glutamine amidotransferase of anthranilate synthase
SaSA218_0449	COG1268	BioY protein
SaSA218_0450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SaSA218_0454	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SaSA218_0458	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SaSA218_0466	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SaSA218_0468	COG0762	integral membrane protein
SaSA218_0469	COG2302	S4 RNA-binding domain
SaSA218_0470	COG3599	regulation of cell shape
SaSA218_0474	COG0542	response to heat
SaSA218_0475	COG4703	Protein of unknown function (DUF1797)
SaSA218_0476	COG0765	amino acid transport
SaSA218_0477	COG1126	abc transporter atp-binding protein
SaSA218_0478	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SaSA218_0480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SaSA218_0481	COG1570	exodeoxyribonuclease VII activity
SaSA218_0484	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SaSA218_0485	COG1438	arginine binding
SaSA218_0486	COG0497	DNA recombination
SaSA218_0487	COG1307	EDD domain protein, DegV family
SaSA218_0488	COG2755	lipolytic protein G-D-S-L family
SaSA218_0497	COG1078	dGTPase activity
SaSA218_0502	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SaSA218_0504	COG2884	Cell division ATP-binding protein ftsE
SaSA218_0505	COG2177	Part of the ABC transporter FtsEX involved in
SaSA218_0509	COG1199	ATP-dependent helicase activity
SaSA218_0509	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SaSA218_0510	COG0436	Aminotransferase
SaSA218_0520	COG0254	rRNA binding
SaSA218_0521	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SaSA218_0522	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SaSA218_0523	COG0716	FMN binding
SaSA218_0524	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SaSA218_0524	COG1605	Chorismate mutase
SaSA218_0527	COG0772	Belongs to the SEDS family
SaSA218_0531	COG0560	Phosphoserine phosphatase
SaSA218_0538	COG1316	TRANSCRIPTIONal
SaSA218_0539	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SaSA218_0541	COG3942	CHAP domain
SaSA218_0541	COG1705	Flagellar rod assembly protein muramidase FlgJ
SaSA218_0563	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SaSA218_0564	COG4555	ABC transporter
SaSA218_0567	COG1131	(ABC) transporter
SaSA218_0580	COG1136	(ABC) transporter
SaSA218_0583	COG0586	Pfam SNARE associated Golgi protein
SaSA218_0584	COG4619	ABC transporter
SaSA218_0585	COG0390	transport system, permease component
SaSA218_0589	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SaSA218_0591	COG2211	Major facilitator Superfamily
SaSA218_0592	COG3250	beta-galactosidase activity
SaSA218_0593	COG2186	Transcriptional regulator
SaSA218_0595	COG1904	glucuronate isomerase
SaSA218_0596	COG1312	Catalyzes the dehydration of D-mannonate
SaSA218_0597	COG1028	Short-chain dehydrogenase reductase Sdr
SaSA218_0601	COG1609	Transcriptional regulator
SaSA218_0604	COG0438	transferase activity, transferring glycosyl groups
SaSA218_0608	COG0765	amino acid transport
SaSA218_0609	COG0765	amino acid transport
SaSA218_0610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SaSA218_0611	COG1126	abc transporter atp-binding protein
SaSA218_0612	COG0745	RESPONSE REGULATOR receiver
SaSA218_0613	COG5002	protein histidine kinase activity
SaSA218_0614	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SaSA218_0615	COG2832	Protein of unknown function (DUF454)
SaSA218_0617	COG1196	nuclear chromosome segregation
SaSA218_0619	COG0552	protein localization to endoplasmic reticulum
SaSA218_0620	COG3689	TIGRFAM TIGR03943 family protein
SaSA218_0621	COG0701	Predicted permease
SaSA218_0624	COG2183	response to ionizing radiation
SaSA218_0625	COG3091	SprT-like family
SaSA218_0626	COG1983	PspC domain protein
SaSA218_0633	COG2801	Transposase and inactivated derivatives
SaSA218_0637	COG4443	Transcriptional Coactivator p15 (PC4)
SaSA218_0639	COG1914	H( )-stimulated, divalent metal cation uptake system
SaSA218_0644	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SaSA218_0647	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SaSA218_0654	COG0772	Belongs to the SEDS family
SaSA218_0658	COG0768	penicillin binding
SaSA218_0661	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SaSA218_0666	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SaSA218_0667	COG2011	ABC-type metal ion transport system permease component
SaSA218_0668	COG1464	Belongs to the NlpA lipoprotein family
SaSA218_0669	COG0513	Belongs to the DEAD box helicase family
SaSA218_0671	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SaSA218_0672	COG0204	Acyl-transferase
SaSA218_0673	COG1596	polysaccharide export
SaSA218_0673	COG1555	photosystem II stabilization
SaSA218_0676	COG1609	Transcriptional regulator
SaSA218_0677	COG0657	acetylesterase activity
SaSA218_0678	COG2226	methyltransferase
SaSA218_0680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SaSA218_0681	COG3711	transcriptional antiterminator
SaSA218_0682	COG1263	PTS System
SaSA218_0682	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SaSA218_0682	COG2190	(PTS) system
SaSA218_0685	COG2801	Transposase and inactivated derivatives
SaSA218_0686	COG3835	regulator
SaSA218_0687	COG1929	Belongs to the glycerate kinase type-1 family
SaSA218_0688	COG2610	gluconate transmembrane transporter activity
SaSA218_0690	COG1846	Transcriptional regulator
SaSA218_0691	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SaSA218_0694	COG0435	Glutathione S-transferase
SaSA218_0695	COG1187	pseudouridine synthase activity
SaSA218_0699	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SaSA218_0702	COG4894	glucomannan catabolic process
SaSA218_0703	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SaSA218_0704	COG1811	Na channel or pump
SaSA218_0705	COG1442	glycosyl transferase family 8
SaSA218_0709	COG1476	TRANSCRIPTIONal
SaSA218_0713	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SaSA218_0714	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SaSA218_0715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SaSA218_0718	COG1012	belongs to the aldehyde dehydrogenase family
SaSA218_0719	COG0726	polysaccharide deacetylase
SaSA218_0721	COG2801	Transposase and inactivated derivatives
SaSA218_0722	COG0513	Belongs to the DEAD box helicase family
SaSA218_0724	COG1956	GAF domain-containing protein
SaSA218_0725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SaSA218_0727	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SaSA218_0734	COG4721	ABC-type cobalt transport system, permease component
SaSA218_0735	COG1122	ATPase activity
SaSA218_0737	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SaSA218_0739	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SaSA218_0740	COG0352	thiamine-phosphate diphosphorylase activity
SaSA218_0741	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SaSA218_0743	COG4109	DRTGG domain
SaSA218_0744	COG0024	Methionine aminopeptidase
SaSA218_0746	COG2246	polysaccharide biosynthetic process
SaSA218_0747	COG4708	membrane
SaSA218_0748	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SaSA218_0749	COG1597	lipid kinase activity
SaSA218_0750	COG1523	belongs to the glycosyl hydrolase 13 family
SaSA218_0751	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SaSA218_0752	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SaSA218_0756	COG0356	it plays a direct role in the translocation of protons across the membrane
SaSA218_0758	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SaSA218_0761	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SaSA218_0762	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SaSA218_0764	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SaSA218_0769	COG0072	phenylalanine-tRNA ligase activity
SaSA218_0769	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SaSA218_0770	COG2321	neutral zinc metallopeptidase
SaSA218_0772	COG1074	ATP-dependent DNA helicase activity
SaSA218_0774	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SaSA218_0775	COG0488	(ABC) transporter
SaSA218_0776	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SaSA218_0777	COG0508	dehydrogenase complex catalyzes the overall conversion of
SaSA218_0777	COG0022	dehydrogenase e1 component
SaSA218_0778	COG0508	dehydrogenase complex catalyzes the overall conversion of
SaSA218_0780	COG0095	Lipoate-protein ligase
SaSA218_0781	COG3442	glutamine amidotransferase
SaSA218_0782	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SaSA218_0783	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SaSA218_0788	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SaSA218_0792	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
SaSA218_0793	COG1518	maintenance of DNA repeat elements
SaSA218_0794	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SaSA218_0802	COG1418	mRNA catabolic process
SaSA218_0805	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SaSA218_0810	COG1131	(ABC) transporter
SaSA218_0811	COG1725	Transcriptional regulator
SaSA218_0814	COG0469	pyruvate kinase activity
SaSA218_0816	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SaSA218_0817	COG2824	Alkylphosphonate utilization operon protein PhnA
SaSA218_0818	COG0765	amino acid transport
SaSA218_0819	COG1126	abc transporter atp-binding protein
SaSA218_0822	COG2801	Transposase and inactivated derivatives
SaSA218_0825	COG2813	Specifically methylates the guanine in position
SaSA218_0826	COG0295	cytidine deaminase activity
SaSA218_0833	COG3764	Sortase (surface protein transpeptidase)
SaSA218_0834	COG0346	lactoylglutathione lyase activity
SaSA218_0839	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SaSA218_0841	COG1464	Belongs to the NlpA lipoprotein family
SaSA218_0847	COG0745	RESPONSE REGULATOR receiver
SaSA218_0848	COG5002	protein histidine kinase activity
SaSA218_0853	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SaSA218_0854	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SaSA218_0855	COG5002	protein histidine kinase activity
SaSA218_0856	COG0745	RESPONSE REGULATOR receiver
SaSA218_0858	COG0704	Plays a role in the regulation of phosphate uptake
SaSA218_0861	COG0581	inorganic phosphate transmembrane transporter activity
SaSA218_0862	COG0573	inorganic phosphate transmembrane transporter activity
SaSA218_0863	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SaSA218_0865	COG0483	inositol monophosphate 1-phosphatase activity
SaSA218_0866	COG4476	Belongs to the UPF0223 family
SaSA218_0867	COG1393	Belongs to the ArsC family
SaSA218_0868	COG0196	riboflavin kinase activity
SaSA218_0875	COG1136	(ABC) transporter
SaSA218_0876	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SaSA218_0877	COG0758	DNA mediated transformation
SaSA218_0878	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SaSA218_0879	COG4604	ABC transporter, ATP-binding protein
SaSA218_0880	COG4605	iron ion homeostasis
SaSA218_0881	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SaSA218_0882	COG0110	maltose O-acetyltransferase activity
SaSA218_0884	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SaSA218_0885	COG1376	ErfK ybiS ycfS ynhG family protein
SaSA218_0886	COG1966	Carbon starvation protein
SaSA218_0887	COG3279	Response regulator of the LytR AlgR family
SaSA218_0888	COG3275	phosphorelay sensor kinase activity
SaSA218_0898	COG0505	Belongs to the CarA family
SaSA218_0900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SaSA218_0901	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SaSA218_0904	COG0488	(ABC) transporter
SaSA218_0906	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SaSA218_0908	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SaSA218_0909	COG2801	Transposase and inactivated derivatives
SaSA218_0918	COG0095	Lipoate-protein ligase
SaSA218_0920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SaSA218_0921	COG4684	Psort location CytoplasmicMembrane, score
SaSA218_0922	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SaSA218_0930	COG2890	protein-(glutamine-N5) methyltransferase activity
SaSA218_0936	COG0431	NADPH-dependent FMN reductase
SaSA218_0936	COG1053	succinate dehydrogenase
SaSA218_0936	COG3976	FMN-binding domain protein
SaSA218_0938	COG2233	PERMEase
SaSA218_0941	COG0477	Major facilitator Superfamily
SaSA218_0944	COG4221	oxidoreductase activity
SaSA218_0946	COG0564	pseudouridine synthase activity
SaSA218_0947	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SaSA218_0948	COG2357	RelA SpoT domain protein
SaSA218_0950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SaSA218_0951	COG1104	cysteine desulfurase activity
SaSA218_0955	COG0628	permease
SaSA218_0956	COG2723	6-phospho-beta-galactosidase activity
SaSA218_0958	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SaSA218_0966	COG0561	phosphatase activity
SaSA218_0970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SaSA218_0971	COG1177	transmembrane transport
SaSA218_0972	COG1176	ABC-type spermidine putrescine transport system, permease component I
SaSA218_0979	COG0285	dihydrofolate synthase activity
SaSA218_0980	COG2962	Rard protein
SaSA218_0984	COG0726	polysaccharide deacetylase
SaSA218_0985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SaSA218_0986	COG1012	belongs to the aldehyde dehydrogenase family
SaSA218_0993	COG2801	Transposase and inactivated derivatives
SaSA218_1004	COG2261	transglycosylase associated protein
SaSA218_1009	COG1115	amino acid carrier protein
SaSA218_1010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SaSA218_1012	COG1346	cytolysis
SaSA218_1014	COG0539	negative regulation of cytoplasmic translation
SaSA218_1016	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SaSA218_1018	COG0187	DNA topoisomerase II activity
SaSA218_1019	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SaSA218_1020	COG2801	Transposase and inactivated derivatives
SaSA218_1027	COG2089	acid synthase
SaSA218_1031	COG1442	glycosyl transferase family 8
SaSA218_1031	COG1216	Glycosyl transferase, family 2
SaSA218_1034	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SaSA218_1035	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SaSA218_1039	COG1316	TRANSCRIPTIONal
SaSA218_1047	COG3842	ATPase activity
SaSA218_1051	COG3527	Alpha-acetolactate decarboxylase
SaSA218_1052	COG0028	Belongs to the TPP enzyme family
SaSA218_1053	COG0457	Tetratricopeptide repeat
SaSA218_1054	COG0628	permease
SaSA218_1056	COG1051	belongs to the nudix hydrolase family
SaSA218_1057	COG5492	domain, Protein
SaSA218_1058	COG1088	dTDP-glucose 4,6-dehydratase activity
SaSA218_1060	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SaSA218_1061	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SaSA218_1063	COG2384	SAM-dependent methyltransferase
SaSA218_1065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SaSA218_1067	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SaSA218_1067	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SaSA218_1068	COG0300	oxidoreductase activity
SaSA218_1072	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SaSA218_1078	COG1573	uracil-dna glycosylase
SaSA218_1079	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SaSA218_1081	COG0584	glycerophosphoryl diester phosphodiesterase
SaSA218_1084	COG0534	Mate efflux family protein
SaSA218_1093	COG2040	homocysteine
SaSA218_1094	COG0833	amino acid
SaSA218_1101	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SaSA218_1103	COG3425	synthase
SaSA218_1106	COG1272	protein, Hemolysin III
SaSA218_1115	COG0745	RESPONSE REGULATOR receiver
SaSA218_1116	COG2357	RelA SpoT domain protein
SaSA218_1117	COG1132	(ABC) transporter
SaSA218_1119	COG1132	(ABC) transporter
SaSA218_1120	COG1132	(ABC) transporter
SaSA218_1122	COG0488	(ABC) transporter
SaSA218_1123	COG0617	tRNA 3'-terminal CCA addition
SaSA218_1128	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SaSA218_1128	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SaSA218_1128	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SaSA218_1129	COG1105	Belongs to the carbohydrate kinase PfkB family
SaSA218_1130	COG1349	DNA-binding transcription factor activity
SaSA218_1137	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SaSA218_1140	COG1837	Belongs to the UPF0109 family
SaSA218_1142	COG0577	efflux transmembrane transporter activity
SaSA218_1143	COG1136	(ABC) transporter
SaSA218_1144	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SaSA218_1146	COG0505	Belongs to the CarA family
SaSA218_1148	COG0564	pseudouridine synthase activity
SaSA218_1150	COG0583	DNA-binding transcription factor activity
SaSA218_1151	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SaSA218_1156	COG0301	tRNA thio-modification
SaSA218_1157	COG1104	cysteine desulfurase activity
SaSA218_1159	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SaSA218_1165	COG1368	sulfuric ester hydrolase activity
SaSA218_1174	COG2244	polysaccharide biosynthetic process
SaSA218_1175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SaSA218_1176	COG1120	ATPase activity
SaSA218_1177	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SaSA218_1179	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SaSA218_1180	COG2801	Transposase and inactivated derivatives
SaSA218_1184	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SaSA218_1185	COG1253	flavin adenine dinucleotide binding
SaSA218_1186	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SaSA218_1187	COG1242	4 iron, 4 sulfur cluster binding
SaSA218_1188	COG0671	phosphoesterase, PA-phosphatase related
SaSA218_1189	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SaSA218_1196	COG0681	Belongs to the peptidase S26 family
SaSA218_1198	COG0297	glycogen (starch) synthase activity
SaSA218_1206	COG3475	LICD family
SaSA218_1209	COG0463	Glycosyl transferase, family 2
SaSA218_1210	COG1215	transferase activity, transferring glycosyl groups
SaSA218_1212	COG1091	dTDP-4-dehydrorhamnose reductase activity
SaSA218_1213	COG2151	metal-sulfur cluster biosynthetic enzyme
SaSA218_1214	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SaSA218_1215	COG0358	DNA primase activity
SaSA218_1216	COG1970	mechanosensitive ion channel activity
SaSA218_1219	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SaSA218_1220	COG0004	ammonium transporteR
SaSA218_1224	COG2271	Major facilitator Superfamily
SaSA218_1225	COG0058	SHG alpha-glucan phosphorylase activity
SaSA218_1226	COG1640	4-alpha-glucanotransferase
SaSA218_1227	COG1609	Transcriptional regulator
SaSA218_1229	COG1175	transmembrane transport
SaSA218_1230	COG3833	ABC-type maltose transport systems, permease component
SaSA218_1231	COG3104	oligopeptide transport
SaSA218_1232	COG2801	Transposase and inactivated derivatives
SaSA218_1234	COG3104	oligopeptide transport
SaSA218_1237	COG0438	transferase activity, transferring glycosyl groups
SaSA218_1238	COG0653	protein targeting
SaSA218_1243	COG1442	glycosyl transferase family 8
SaSA218_1251	COG0765	amino acid transport
SaSA218_1252	COG1126	abc transporter atp-binding protein
SaSA218_1257	COG2309	aminopeptidase activity
SaSA218_1260	COG1187	pseudouridine synthase activity
SaSA218_1261	COG0656	L-ascorbic acid biosynthetic process
SaSA218_1262	COG0778	Nitroreductase
SaSA218_1263	COG0346	lactoylglutathione lyase activity
SaSA218_1264	COG0463	Glycosyl transferase, family 2
SaSA218_1265	COG1113	amino acid transport
SaSA218_1267	COG0557	exoribonuclease II activity
SaSA218_1269	COG2814	Major facilitator Superfamily
SaSA218_1271	COG1131	(ABC) transporter
SaSA218_1281	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SaSA218_1286	COG1702	phosphate starvation-inducible protein PhoH
SaSA218_1294	COG0444	Belongs to the ABC transporter superfamily
SaSA218_1295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SaSA218_1296	COG0601	transmembrane transport
SaSA218_1297	COG0747	negative chemotaxis
SaSA218_1299	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SaSA218_1301	COG1473	amidohydrolase
SaSA218_1302	COG0583	DNA-binding transcription factor activity
SaSA218_1305	COG1674	ftsk spoiiie
SaSA218_1306	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SaSA218_1311	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SaSA218_1316	COG0673	inositol 2-dehydrogenase activity
SaSA218_1318	COG1028	Short-chain dehydrogenase reductase Sdr
SaSA218_1322	COG1215	transferase activity, transferring glycosyl groups
SaSA218_1328	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SaSA218_1328	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SaSA218_1331	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SaSA218_1333	COG0708	Exodeoxyribonuclease III
SaSA218_1334	COG1393	Belongs to the ArsC family
SaSA218_1335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SaSA218_1336	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SaSA218_1338	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SaSA218_1342	COG0470	DNA polymerase III
SaSA218_1344	COG0517	IMP dehydrogenase activity
SaSA218_1345	COG0410	ABC transporter
SaSA218_1346	COG0411	ABC transporter
SaSA218_1348	COG0559	Belongs to the binding-protein-dependent transport system permease family
SaSA218_1353	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SaSA218_1355	COG0531	amino acid
SaSA218_1356	COG0569	domain protein
SaSA218_1357	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SaSA218_1358	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SaSA218_1360	COG2801	Transposase and inactivated derivatives
SaSA218_1362	COG1187	pseudouridine synthase activity
SaSA218_1368	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SaSA218_1369	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SaSA218_1372	COG1827	regulation of RNA biosynthetic process
SaSA218_1375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SaSA218_1376	COG1254	Belongs to the acylphosphatase family
SaSA218_1378	COG0765	amino acid transport
SaSA218_1379	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SaSA218_1382	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SaSA218_1386	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SaSA218_1388	COG1484	DNA-dependent DNA replication
SaSA218_1392	COG5002	protein histidine kinase activity
SaSA218_1393	COG0745	RESPONSE REGULATOR receiver
SaSA218_1395	COG0501	Belongs to the peptidase M48B family
SaSA218_1396	COG1704	LemA family
SaSA218_1397	COG0357	Ribosomal RNA small subunit methyltransferase G
SaSA218_1398	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SaSA218_1399	COG0569	domain protein
SaSA218_1401	COG1122	ATPase activity
SaSA218_1402	COG1122	ATPase activity
SaSA218_1405	COG1114	Component of the transport system for branched-chain amino acids
SaSA218_1406	COG1063	alcohol dehydrogenase
SaSA218_1411	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SaSA218_1412	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SaSA218_1414	COG2376	Dihydroxyacetone kinase
SaSA218_1415	COG1309	transcriptional regulator
SaSA218_1416	COG2376	Dihydroxyacetone kinase
SaSA218_1417	COG1461	Dihydroxyacetone kinase
SaSA218_1418	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SaSA218_1419	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SaSA218_1421	COG0789	Transcriptional regulator
SaSA218_1422	COG1323	Belongs to the UPF0348 family
SaSA218_1424	COG2226	methyltransferase
SaSA218_1425	COG0799	negative regulation of ribosome biogenesis
SaSA218_1427	COG1713	HD superfamily hydrolase involved in NAD metabolism
SaSA218_1428	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SaSA218_1429	COG1534	Rna-binding protein
SaSA218_1430	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SaSA218_1431	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SaSA218_1434	COG0154	amidase activity
SaSA218_1435	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SaSA218_1436	COG0574	Belongs to the PEP-utilizing enzyme family
SaSA218_1436	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SaSA218_1438	COG0517	IMP dehydrogenase activity
SaSA218_1440	COG1335	isochorismatase
SaSA218_1441	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SaSA218_1442	COG0436	Aminotransferase
SaSA218_1443	COG0589	response to stress
SaSA218_1445	COG0252	asparaginase activity
SaSA218_1447	COG4989	oxidoreductase activity
SaSA218_1448	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SaSA218_1449	COG1705	Flagellar rod assembly protein muramidase FlgJ
SaSA218_1449	COG3942	CHAP domain
SaSA218_1452	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SaSA218_1454	COG1482	cell wall glycoprotein biosynthetic process
SaSA218_1455	COG1940	carbohydrate kinase activity
SaSA218_1456	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SaSA218_1456	COG2190	(PTS) system
SaSA218_1456	COG1263	PTS System
SaSA218_1457	COG1621	beta-fructofuranosidase activity
SaSA218_1458	COG1609	Transcriptional regulator
SaSA218_1465	COG2131	deaminase
SaSA218_1466	COG0006	proline dipeptidase activity
SaSA218_1468	COG2814	Major facilitator Superfamily
SaSA218_1473	COG0629	single-stranded DNA binding
SaSA218_1475	COG1194	a g-specific adenine glycosylase
SaSA218_1477	COG3118	belongs to the thioredoxin family
SaSA218_1482	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SaSA218_1483	COG0681	Belongs to the peptidase S26 family
SaSA218_1484	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SaSA218_1487	COG1882	Formate acetyltransferase
SaSA218_1489	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SaSA218_1492	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SaSA218_1494	COG2814	Major facilitator Superfamily
SaSA218_1495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SaSA218_1498	COG0142	geranyltranstransferase activity
SaSA218_1499	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SaSA218_1500	COG4988	ABC transporter
SaSA218_1501	COG1294	oxidase, subunit
SaSA218_1502	COG1271	oxidase subunit
SaSA218_1503	COG1252	NADH dehydrogenase
SaSA218_1508	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SaSA218_1512	COG2081	HI0933 family
SaSA218_1517	COG0456	acetyltransferase
SaSA218_1518	COG1214	PFAM Peptidase M22, glycoprotease
SaSA218_1521	COG3942	CHAP domain
SaSA218_1522	COG0174	glutamine synthetase
SaSA218_1523	COG0789	Transcriptional regulator
SaSA218_1526	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SaSA218_1532	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SaSA218_1534	COG1322	Protein conserved in bacteria
SaSA218_1537	COG1162	GTPase activity
SaSA218_1541	COG0693	protein deglycase activity
SaSA218_1543	COG0084	hydrolase, TatD family'
SaSA218_1548	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SaSA218_1550	COG1696	Membrane protein involved in D-alanine export
SaSA218_1558	COG3448	diguanylate cyclase activity
SaSA218_1558	COG4175	Glycine betaine
SaSA218_1559	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SaSA218_1565	COG3775	system Galactitol-specific IIC component
SaSA218_1568	COG1609	Transcriptional regulator
SaSA218_1569	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SaSA218_1575	COG3037	sugar-specific permease SgaT UlaA
SaSA218_1578	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SaSA218_1581	COG2918	glutathione biosynthetic process
SaSA218_1581	COG1181	Belongs to the D-alanine--D-alanine ligase family
SaSA218_1585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SaSA218_1586	COG1428	Deoxynucleoside kinase
SaSA218_1588	COG0542	response to heat
SaSA218_1589	COG4463	regulation of RNA biosynthetic process
SaSA218_1592	COG0052	Belongs to the universal ribosomal protein uS2 family
SaSA218_1593	COG0450	alkyl hydroperoxide reductase
SaSA218_1595	COG0025	NhaP-type Na H and K H
SaSA218_1597	COG1619	proteins homologs of microcin C7 resistance protein MccF
SaSA218_1598	COG3590	peptidase
SaSA218_1603	COG1609	Transcriptional regulator
SaSA218_1605	COG3716	PTS system mannose fructose sorbose family IID component
SaSA218_1606	COG3715	PTS system
SaSA218_1607	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SaSA218_1608	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SaSA218_1610	COG1028	Short-chain dehydrogenase reductase Sdr
SaSA218_1619	COG2176	DNA-directed DNA polymerase activity
SaSA218_1620	COG1705	Flagellar rod assembly protein muramidase FlgJ
SaSA218_1620	COG1388	LysM domain
SaSA218_1623	COG4589	Belongs to the CDS family
SaSA218_1624	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SaSA218_1625	COG1862	Preprotein translocase
SaSA218_1630	COG4565	transcriptional regulatory protein
SaSA218_1631	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SaSA218_1633	COG3842	ATPase activity
SaSA218_1636	COG3684	Belongs to the aldolase LacD family
SaSA218_1637	COG1105	Belongs to the carbohydrate kinase PfkB family
SaSA218_1638	COG0698	ribose 5-phosphate isomerase
SaSA218_1639	COG0698	ribose 5-phosphate isomerase
SaSA218_1645	COG2801	Transposase and inactivated derivatives
SaSA218_1649	COG1490	D-aminoacyl-tRNA deacylase activity
SaSA218_1653	COG1363	Peptidase, m42
SaSA218_1658	COG2972	Histidine kinase
SaSA218_1659	COG3716	PTS system mannose fructose sorbose family IID component
SaSA218_1660	COG3715	PTS system
SaSA218_1665	COG1131	(ABC) transporter
SaSA218_1667	COG2274	protein secretion by the type I secretion system
SaSA218_1668	COG2274	protein secretion by the type I secretion system
SaSA218_1670	COG3290	protein histidine kinase activity
SaSA218_1671	COG3279	Response regulator of the LytR AlgR family
SaSA218_1674	COG2190	(PTS) system
SaSA218_1674	COG1263	PTS System
SaSA218_1674	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SaSA218_1675	COG5002	protein histidine kinase activity
SaSA218_1678	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SaSA218_1679	COG0581	inorganic phosphate transmembrane transporter activity
SaSA218_1681	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SaSA218_1683	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SaSA218_1684	COG2264	protein methyltransferase activity
SaSA218_1686	COG0789	Transcriptional regulator
SaSA218_1693	COG0456	acetyltransferase
SaSA218_1694	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SaSA218_1699	COG1131	(ABC) transporter
SaSA218_1706	COG1131	(ABC) transporter
SaSA218_1708	COG1396	sequence-specific DNA binding
SaSA218_1711	COG2801	Transposase and inactivated derivatives
SaSA218_1713	COG2897	thiosulfate sulfurtransferase activity
SaSA218_1716	COG0371	Dehydrogenase
SaSA218_1718	COG0646	methionine synthase
SaSA218_1718	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SaSA218_1721	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SaSA218_1723	COG0745	RESPONSE REGULATOR receiver
SaSA218_1726	COG0495	leucyl-tRNA aminoacylation
SaSA218_1727	COG2814	Major facilitator Superfamily
SaSA218_1728	COG4667	esterase of the alpha-beta hydrolase superfamily
SaSA218_1732	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SaSA218_1733	COG0564	pseudouridine synthase activity
SaSA218_1737	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SaSA218_1738	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SaSA218_1742	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SaSA218_1743	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SaSA218_1743	COG1116	anion transmembrane transporter activity
SaSA218_1744	COG4120	Belongs to the binding-protein-dependent transport system permease family
SaSA218_1746	COG0561	phosphatase activity
SaSA218_1747	COG2514	catechol 2,3-dioxygenase activity
SaSA218_1748	COG3022	response to hydroperoxide
SaSA218_1749	COG0602	queuosine metabolic process
SaSA218_1753	COG1328	CTP reductase activity
SaSA218_1756	COG3906	Belongs to the UPF0473 family
SaSA218_1759	COG1393	Belongs to the ArsC family
SaSA218_1760	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SaSA218_1761	COG1058	Belongs to the CinA family
SaSA218_1761	COG1546	Belongs to the CinA family
SaSA218_1762	COG2818	Glycosylase
SaSA218_1769	COG0018	arginyl-trna synthetase
SaSA218_1771	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SaSA218_1772	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SaSA218_1774	COG0124	histidyl-tRNA synthetase
SaSA218_1777	COG2801	Transposase and inactivated derivatives
SaSA218_1779	COG1288	antiporter activity
SaSA218_1783	COG1174	glycine betaine transport
SaSA218_1784	COG0392	lysyltransferase activity
SaSA218_1784	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SaSA218_1786	COG3759	membrane
SaSA218_1792	COG0305	Participates in initiation and elongation during chromosome replication
SaSA218_1797	COG0482	sulfurtransferase activity
SaSA218_1798	COG1760	l-serine dehydratase
SaSA218_1799	COG1760	l-serine dehydratase
SaSA218_1800	COG0741	lytic transglycosylase activity
SaSA218_1801	COG1388	LysM domain
SaSA218_1805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SaSA218_1806	COG0612	Peptidase, M16
SaSA218_1807	COG0612	Peptidase, M16
SaSA218_1808	COG2501	S4 domain
SaSA218_1817	COG2235	arginine
SaSA218_1819	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SaSA218_1821	COG0549	Belongs to the carbamate kinase family
SaSA218_1822	COG0180	Tryptophanyl-tRNA synthetase
SaSA218_1825	COG0488	(ABC) transporter
SaSA218_1826	COG4485	Bacterial membrane protein, YfhO
SaSA218_1828	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SaSA218_1829	COG1475	DNA binding