locus-tag	class	description
MGAS9429_Spy0002	COG0592	DNA-directed DNA polymerase activity
MGAS9429_Spy0004	COG0012	GTP binding
MGAS9429_Spy0006	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MGAS9429_Spy0007	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MGAS9429_Spy0013	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MGAS9429_Spy0014	COG0531	amino acid
MGAS9429_Spy0017	COG3942	CHAP domain
MGAS9429_Spy0021	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MGAS9429_Spy0023	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MGAS9429_Spy0026	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MGAS9429_Spy0030	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MGAS9429_Spy0034	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MGAS9429_Spy0037	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MGAS9429_Spy0040	COG1454	alcohol dehydrogenase
MGAS9429_Spy0040	COG1012	belongs to the aldehyde dehydrogenase family
MGAS9429_Spy0041	COG1064	alcohol dehydrogenase
MGAS9429_Spy0042	COG0534	Mate efflux family protein
MGAS9429_Spy0064	COG0201	protein transport
MGAS9429_Spy0067	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MGAS9429_Spy0078	COG1121	(ABC) transporter
MGAS9429_Spy0079	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MGAS9429_Spy0082	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS9429_Spy0087	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MGAS9429_Spy0088	COG1459	type II secretion system
MGAS9429_Spy0089	COG4537	Required for transformation and DNA binding
MGAS9429_Spy0097	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MGAS9429_Spy0098	COG1363	Peptidase, m42
MGAS9429_Spy0101	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS9429_Spy0102	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MGAS9429_Spy0104	COG1428	Deoxynucleoside kinase
MGAS9429_Spy0105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MGAS9429_Spy0114	COG4509	Sortase family
MGAS9429_Spy0119	COG2031	fatty acid transporter
MGAS9429_Spy0122	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS9429_Spy0125	COG0251	oxidation-reduction process
MGAS9429_Spy0128	COG1269	ATP hydrolysis coupled proton transport
MGAS9429_Spy0129	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MGAS9429_Spy0131	COG1527	subunit (C
MGAS9429_Spy0132	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
MGAS9429_Spy0139	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS9429_Spy0148	COG0626	cystathionine gamma-synthase activity
MGAS9429_Spy0150	COG3037	sugar-specific permease SgaT UlaA
MGAS9429_Spy0154	COG3623	hexulose-6-phosphate isomerase
MGAS9429_Spy0159	COG4175	Glycine betaine
MGAS9429_Spy0159	COG3448	diguanylate cyclase activity
MGAS9429_Spy0161	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS9429_Spy0161	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS9429_Spy0165	COG3969	phosphoadenosine phosphosulfate
MGAS9429_Spy0166	COG1475	DNA binding
MGAS9429_Spy0168	COG2801	Transposase and inactivated derivatives
MGAS9429_Spy0169	COG2801	Transposase and inactivated derivatives
MGAS9429_Spy0172	COG0157	Belongs to the NadC ModD family
MGAS9429_Spy0173	COG2801	Transposase and inactivated derivatives
MGAS9429_Spy0179	COG1268	BioY protein
MGAS9429_Spy0180	COG5433	transposase activity
MGAS9429_Spy0181	COG1234	tRNA 3'-trailer cleavage
MGAS9429_Spy0189	COG5433	transposase activity
MGAS9429_Spy0193	COG0457	Tetratricopeptide repeat
MGAS9429_Spy0193	COG0705	Rhomboid family
MGAS9429_Spy0197	COG1132	(ABC) transporter
MGAS9429_Spy0198	COG1132	(ABC) transporter
MGAS9429_Spy0200	COG0756	dUTP diphosphatase activity
MGAS9429_Spy0205	COG3290	protein histidine kinase activity
MGAS9429_Spy0210	COG1847	R3H domain protein
MGAS9429_Spy0215	COG1175	transmembrane transport
MGAS9429_Spy0216	COG0395	ABC-type sugar transport system, permease component
MGAS9429_Spy0218	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MGAS9429_Spy0221	COG0084	hydrolase, TatD family'
MGAS9429_Spy0227	COG1564	THIamine pyrophosphokinase
MGAS9429_Spy0228	COG1322	Protein conserved in bacteria
MGAS9429_Spy0230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MGAS9429_Spy0238	COG0765	amino acid transport
MGAS9429_Spy0242	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MGAS9429_Spy0245	COG0719	Fe-S assembly protein
MGAS9429_Spy0246	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MGAS9429_Spy0249	COG1686	Belongs to the peptidase S11 family
MGAS9429_Spy0250	COG1686	Belongs to the peptidase S11 family
MGAS9429_Spy0251	COG4166	transmembrane transport
MGAS9429_Spy0252	COG0601	transmembrane transport
MGAS9429_Spy0253	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MGAS9429_Spy0254	COG0444	Belongs to the ABC transporter superfamily
MGAS9429_Spy0259	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MGAS9429_Spy0260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MGAS9429_Spy0261	COG1534	Rna-binding protein
MGAS9429_Spy0263	COG1713	HD superfamily hydrolase involved in NAD metabolism
MGAS9429_Spy0264	COG0799	negative regulation of ribosome biogenesis
MGAS9429_Spy0265	COG2226	methyltransferase
MGAS9429_Spy0269	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS9429_Spy0270	COG1464	Belongs to the NlpA lipoprotein family
MGAS9429_Spy0273	COG1114	Component of the transport system for branched-chain amino acids
MGAS9429_Spy0275	COG0569	domain protein
MGAS9429_Spy0276	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MGAS9429_Spy0278	COG1704	LemA family
MGAS9429_Spy0282	COG0745	RESPONSE REGULATOR receiver
MGAS9429_Spy0286	COG1484	DNA-dependent DNA replication
MGAS9429_Spy0288	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MGAS9429_Spy0292	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MGAS9429_Spy0296	COG1254	Belongs to the acylphosphatase family
MGAS9429_Spy0297	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS9429_Spy0309	COG1187	pseudouridine synthase activity
MGAS9429_Spy0312	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MGAS9429_Spy0313	COG0671	phosphoesterase, PA-phosphatase related
MGAS9429_Spy0314	COG1242	4 iron, 4 sulfur cluster binding
MGAS9429_Spy0315	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MGAS9429_Spy0316	COG1253	flavin adenine dinucleotide binding
MGAS9429_Spy0317	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS9429_Spy0320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS9429_Spy0321	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS9429_Spy0322	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MGAS9429_Spy0323	COG1120	ATPase activity
MGAS9429_Spy0325	COG2244	polysaccharide biosynthetic process
MGAS9429_Spy0330	COG5433	transposase activity
MGAS9429_Spy0333	COG0470	DNA polymerase III
MGAS9429_Spy0341	COG1393	Belongs to the ArsC family
MGAS9429_Spy0342	COG0708	Exodeoxyribonuclease III
MGAS9429_Spy0343	COG1304	FMN binding
MGAS9429_Spy0362	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS9429_Spy0363	COG0673	inositol 2-dehydrogenase activity
MGAS9429_Spy0366	COG0494	nUDIX hydrolase
MGAS9429_Spy0368	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MGAS9429_Spy0381	COG2996	Protein conserved in bacteria
MGAS9429_Spy0386	COG1702	phosphate starvation-inducible protein PhoH
MGAS9429_Spy0387	COG1573	uracil-dna glycosylase
MGAS9429_Spy0389	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MGAS9429_Spy0393	COG3328	transposase activity
MGAS9429_Spy0409	COG0433	COG0433 Predicted ATPase
MGAS9429_Spy0410	COG2814	Major facilitator Superfamily
MGAS9429_Spy0413	COG0557	exoribonuclease II activity
MGAS9429_Spy0419	COG0463	Glycosyl transferase, family 2
MGAS9429_Spy0420	COG0346	lactoylglutathione lyase activity
MGAS9429_Spy0421	COG0778	Nitroreductase
MGAS9429_Spy0422	COG0006	proline dipeptidase activity
MGAS9429_Spy0423	COG1609	Transcriptional regulator
MGAS9429_Spy0425	COG0438	transferase activity, transferring glycosyl groups
MGAS9429_Spy0427	COG4555	ABC transporter
MGAS9429_Spy0431	COG0183	Belongs to the thiolase family
MGAS9429_Spy0434	COG0745	RESPONSE REGULATOR receiver
MGAS9429_Spy0435	COG5002	protein histidine kinase activity
MGAS9429_Spy0436	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MGAS9429_Spy0438	COG1196	nuclear chromosome segregation
MGAS9429_Spy0440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MGAS9429_Spy0462	COG0561	phosphatase activity
MGAS9429_Spy0463	COG0561	phosphatase activity
MGAS9429_Spy0464	COG0552	protein localization to endoplasmic reticulum
MGAS9429_Spy0465	COG0477	Major facilitator Superfamily
MGAS9429_Spy0466	COG3711	transcriptional antiterminator
MGAS9429_Spy0467	COG1263	PTS System
MGAS9429_Spy0467	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS9429_Spy0467	COG2190	(PTS) system
MGAS9429_Spy0469	COG3689	TIGRFAM TIGR03943 family protein
MGAS9429_Spy0470	COG0701	Predicted permease
MGAS9429_Spy0472	COG2183	response to ionizing radiation
MGAS9429_Spy0483	COG4443	Transcriptional Coactivator p15 (PC4)
MGAS9429_Spy0487	COG0588	phosphoglycerate mutase activity
MGAS9429_Spy0493	COG0386	Belongs to the glutathione peroxidase family
MGAS9429_Spy0494	COG1164	Oligoendopeptidase f
MGAS9429_Spy0496	COG0772	Belongs to the SEDS family
MGAS9429_Spy0506	COG1078	dGTPase activity
MGAS9429_Spy0508	COG1609	Transcriptional regulator
MGAS9429_Spy0510	COG3716	PTS system mannose fructose sorbose family IID component
MGAS9429_Spy0511	COG3715	PTS system
MGAS9429_Spy0512	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS9429_Spy0515	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS9429_Spy0518	COG0800	Aldolase
MGAS9429_Spy0519	COG0546	phosphoglycolate phosphatase activity
MGAS9429_Spy0520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MGAS9429_Spy0522	COG2884	Cell division ATP-binding protein ftsE
MGAS9429_Spy0523	COG2177	Part of the ABC transporter FtsEX involved in
MGAS9429_Spy0526	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MGAS9429_Spy0526	COG1199	ATP-dependent helicase activity
MGAS9429_Spy0527	COG0436	Aminotransferase
MGAS9429_Spy0564	COG1598	PFAM Uncharacterised protein family UPF0150
MGAS9429_Spy0573	COG0740	serine-type endopeptidase activity
MGAS9429_Spy0575	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MGAS9429_Spy0592	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS9429_Spy0597	COG2188	Transcriptional regulator
MGAS9429_Spy0598	COG2222	sugar isomerase
MGAS9429_Spy0600	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MGAS9429_Spy0601	COG0716	FMN binding
MGAS9429_Spy0603	COG0038	chloride channel
MGAS9429_Spy0620	COG1131	(ABC) transporter
MGAS9429_Spy0626	COG4708	membrane
MGAS9429_Spy0628	COG1597	lipid kinase activity
MGAS9429_Spy0645	COG0577	efflux transmembrane transporter activity
MGAS9429_Spy0647	COG2321	neutral zinc metallopeptidase
MGAS9429_Spy0650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS9429_Spy0652	COG1970	mechanosensitive ion channel activity
MGAS9429_Spy0653	COG0358	DNA primase activity
MGAS9429_Spy0654	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MGAS9429_Spy0655	COG2151	metal-sulfur cluster biosynthetic enzyme
MGAS9429_Spy0665	COG1216	Glycosyl transferase, family 2
MGAS9429_Spy0677	COG1368	sulfuric ester hydrolase activity
MGAS9429_Spy0678	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MGAS9429_Spy0682	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MGAS9429_Spy0683	COG0285	dihydrofolate synthase activity
MGAS9429_Spy0685	COG1104	cysteine desulfurase activity
MGAS9429_Spy0690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MGAS9429_Spy0691	COG0583	DNA-binding transcription factor activity
MGAS9429_Spy0693	COG0564	pseudouridine synthase activity
MGAS9429_Spy0700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MGAS9429_Spy0701	COG1136	(ABC) transporter
MGAS9429_Spy0702	COG0577	efflux transmembrane transporter activity
MGAS9429_Spy0703	COG0584	glycerophosphoryl diester phosphodiesterase
MGAS9429_Spy0705	COG1837	Belongs to the UPF0109 family
MGAS9429_Spy0715	COG1349	DNA-binding transcription factor activity
MGAS9429_Spy0716	COG1105	Belongs to the carbohydrate kinase PfkB family
MGAS9429_Spy0717	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS9429_Spy0717	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS9429_Spy0717	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS9429_Spy0718	COG1388	LysM domain
MGAS9429_Spy0718	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS9429_Spy0719	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS9429_Spy0719	COG1388	LysM domain
MGAS9429_Spy0720	COG2801	Transposase and inactivated derivatives
MGAS9429_Spy0725	COG0105	UTP biosynthetic process
MGAS9429_Spy0729	COG0488	(ABC) transporter
MGAS9429_Spy0732	COG0242	peptide deformylase activity
MGAS9429_Spy0733	COG0737	Belongs to the 5'-nucleotidase family
MGAS9429_Spy0734	COG2357	RelA SpoT domain protein
MGAS9429_Spy0735	COG0745	RESPONSE REGULATOR receiver
MGAS9429_Spy0743	COG3425	synthase
MGAS9429_Spy0745	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MGAS9429_Spy0757	COG0583	DNA-binding transcription factor activity
MGAS9429_Spy0762	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS9429_Spy0763	COG0765	amino acid transport
MGAS9429_Spy0767	COG0187	DNA topoisomerase II activity
MGAS9429_Spy0769	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MGAS9429_Spy0771	COG0539	negative regulation of cytoplasmic translation
MGAS9429_Spy0776	COG5433	transposase activity
MGAS9429_Spy0780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MGAS9429_Spy0781	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MGAS9429_Spy0783	COG0300	oxidoreductase activity
MGAS9429_Spy0784	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MGAS9429_Spy0784	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MGAS9429_Spy0785	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MGAS9429_Spy0785	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MGAS9429_Spy0788	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MGAS9429_Spy0789	COG2384	SAM-dependent methyltransferase
MGAS9429_Spy0791	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MGAS9429_Spy0792	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MGAS9429_Spy0794	COG1088	dTDP-glucose 4,6-dehydratase activity
MGAS9429_Spy0795	COG0582	viral genome integration into host DNA
MGAS9429_Spy0799	COG3561	AntA/AntB antirepressor
MGAS9429_Spy0852	COG1051	belongs to the nudix hydrolase family
MGAS9429_Spy0853	COG0628	permease
MGAS9429_Spy0854	COG0457	Tetratricopeptide repeat
MGAS9429_Spy0860	COG1129	ABC transporter
MGAS9429_Spy0864	COG0488	(ABC) transporter
MGAS9429_Spy0865	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MGAS9429_Spy0866	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS9429_Spy0866	COG0022	dehydrogenase e1 component
MGAS9429_Spy0867	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS9429_Spy0871	COG5492	domain, Protein
MGAS9429_Spy0872	COG0095	Lipoate-protein ligase
MGAS9429_Spy0873	COG3442	glutamine amidotransferase
MGAS9429_Spy0874	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS9429_Spy0875	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MGAS9429_Spy0880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MGAS9429_Spy0882	COG0647	UMP catabolic process
MGAS9429_Spy0886	COG1518	maintenance of DNA repeat elements
MGAS9429_Spy0887	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS9429_Spy0890	COG0105	UTP biosynthetic process
MGAS9429_Spy0892	COG5433	transposase activity
MGAS9429_Spy0899	COG3715	PTS system
MGAS9429_Spy0900	COG3716	PTS system mannose fructose sorbose family IID component
MGAS9429_Spy0901	COG2972	Histidine kinase
MGAS9429_Spy0902	COG4753	response regulator
MGAS9429_Spy0902	COG2207	Transcriptional regulator
MGAS9429_Spy0904	COG1012	belongs to the aldehyde dehydrogenase family
MGAS9429_Spy0907	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS9429_Spy0930	COG1396	sequence-specific DNA binding
MGAS9429_Spy0939	COG0285	dihydrofolate synthase activity
MGAS9429_Spy0946	COG1176	ABC-type spermidine putrescine transport system, permease component I
MGAS9429_Spy0947	COG1177	transmembrane transport
MGAS9429_Spy0948	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MGAS9429_Spy0949	COG4565	transcriptional regulatory protein
MGAS9429_Spy0950	COG3290	protein histidine kinase activity
MGAS9429_Spy0951	COG3493	citrate carrier protein
MGAS9429_Spy0954	COG3700	Belongs to the class B bacterial acid phosphatase family
MGAS9429_Spy0955	COG0038	chloride channel
MGAS9429_Spy0958	COG0628	permease
MGAS9429_Spy0960	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MGAS9429_Spy0963	COG1104	cysteine desulfurase activity
MGAS9429_Spy0966	COG2357	RelA SpoT domain protein
MGAS9429_Spy0968	COG0564	pseudouridine synthase activity
MGAS9429_Spy0969	COG0280	phosphate acetyltransferase
MGAS9429_Spy0970	COG4221	oxidoreductase activity
MGAS9429_Spy0973	COG1174	glycine betaine transport
MGAS9429_Spy0976	COG2233	PERMEase
MGAS9429_Spy0981	COG2890	protein-(glutamine-N5) methyltransferase activity
MGAS9429_Spy0988	COG1132	(ABC) transporter
MGAS9429_Spy0989	COG1132	(ABC) transporter
MGAS9429_Spy0993	COG3764	Sortase (surface protein transpeptidase)
MGAS9429_Spy0994	COG0346	lactoylglutathione lyase activity
MGAS9429_Spy0998	COG1272	protein, Hemolysin III
MGAS9429_Spy1002	COG0758	DNA mediated transformation
MGAS9429_Spy1003	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MGAS9429_Spy1012	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
MGAS9429_Spy1017	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MGAS9429_Spy1023	COG0488	(ABC) transporter
MGAS9429_Spy1025	COG0352	thiamine-phosphate diphosphorylase activity
MGAS9429_Spy1025	COG0351	phosphomethylpyrimidine kinase
MGAS9429_Spy1026	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MGAS9429_Spy1028	COG1328	CTP reductase activity
MGAS9429_Spy1028	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MGAS9429_Spy1029	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MGAS9429_Spy1035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MGAS9429_Spy1037	COG0095	Lipoate-protein ligase
MGAS9429_Spy1039	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MGAS9429_Spy1040	COG4684	Psort location CytoplasmicMembrane, score
MGAS9429_Spy1041	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS9429_Spy1045	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS9429_Spy1046	COG0295	cytidine deaminase activity
MGAS9429_Spy1047	COG2813	Specifically methylates the guanine in position
MGAS9429_Spy1050	COG5002	protein histidine kinase activity
MGAS9429_Spy1051	COG0745	RESPONSE REGULATOR receiver
MGAS9429_Spy1054	COG0704	Plays a role in the regulation of phosphate uptake
MGAS9429_Spy1057	COG0581	inorganic phosphate transmembrane transporter activity
MGAS9429_Spy1058	COG0573	inorganic phosphate transmembrane transporter activity
MGAS9429_Spy1059	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MGAS9429_Spy1060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS9429_Spy1060	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MGAS9429_Spy1061	COG0483	inositol monophosphate 1-phosphatase activity
MGAS9429_Spy1064	COG0196	riboflavin kinase activity
MGAS9429_Spy1070	COG1136	(ABC) transporter
MGAS9429_Spy1070	COG4591	ABC-type transport system involved in lipoprotein release permease component
MGAS9429_Spy1082	COG1115	amino acid carrier protein
MGAS9429_Spy1084	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MGAS9429_Spy1086	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS9429_Spy1087	COG1126	abc transporter atp-binding protein
MGAS9429_Spy1088	COG0765	amino acid transport
MGAS9429_Spy1089	COG2824	Alkylphosphonate utilization operon protein PhnA
MGAS9429_Spy1092	COG0469	pyruvate kinase activity
MGAS9429_Spy1095	COG1725	Transcriptional regulator
MGAS9429_Spy1096	COG1131	(ABC) transporter
MGAS9429_Spy1101	COG0058	SHG alpha-glucan phosphorylase activity
MGAS9429_Spy1102	COG1640	4-alpha-glucanotransferase
MGAS9429_Spy1103	COG1609	Transcriptional regulator
MGAS9429_Spy1104	COG2182	Extracellular solute-binding protein
MGAS9429_Spy1105	COG1175	transmembrane transport
MGAS9429_Spy1106	COG3833	ABC-type maltose transport systems, permease component
MGAS9429_Spy1111	COG0657	acetylesterase activity
MGAS9429_Spy1112	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MGAS9429_Spy1114	COG1696	Membrane protein involved in D-alanine export
MGAS9429_Spy1118	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS9429_Spy1119	COG1126	abc transporter atp-binding protein
MGAS9429_Spy1122	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS9429_Spy1124	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS9429_Spy1126	COG3711	transcriptional antiterminator
MGAS9429_Spy1126	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS9429_Spy1128	COG2723	6-phospho-beta-galactosidase activity
MGAS9429_Spy1134	COG2801	Transposase and inactivated derivatives
MGAS9429_Spy1135	COG1187	pseudouridine synthase activity
MGAS9429_Spy1137	COG2814	Major facilitator Superfamily
MGAS9429_Spy1148	COG4109	DRTGG domain
MGAS9429_Spy1149	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MGAS9429_Spy1154	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MGAS9429_Spy1154	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MGAS9429_Spy1157	COG5433	transposase activity
MGAS9429_Spy1159	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MGAS9429_Spy1160	COG1956	GAF domain-containing protein
MGAS9429_Spy1164	COG0513	Belongs to the DEAD box helicase family
MGAS9429_Spy1165	COG0726	polysaccharide deacetylase
MGAS9429_Spy1169	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MGAS9429_Spy1170	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MGAS9429_Spy1171	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MGAS9429_Spy1174	COG2801	Transposase and inactivated derivatives
MGAS9429_Spy1175	COG2801	Transposase and inactivated derivatives
MGAS9429_Spy1178	COG1476	TRANSCRIPTIONal
MGAS9429_Spy1182	COG2223	nitrite transmembrane transporter activity
MGAS9429_Spy1185	COG1187	pseudouridine synthase activity
MGAS9429_Spy1194	COG0658	competence protein
MGAS9429_Spy1194	COG2333	competence protein COMEC
MGAS9429_Spy1195	COG1555	photosystem II stabilization
MGAS9429_Spy1195	COG1596	polysaccharide export
MGAS9429_Spy1196	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MGAS9429_Spy1197	COG0204	Acyl-transferase
MGAS9429_Spy1200	COG0513	Belongs to the DEAD box helicase family
MGAS9429_Spy1204	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS9429_Spy1208	COG2116	formate transmembrane transporter activity
MGAS9429_Spy1211	COG1827	regulation of RNA biosynthetic process
MGAS9429_Spy1216	COG2217	Heavy metal translocating P-type atpase
MGAS9429_Spy1219	COG2755	lipolytic protein G-D-S-L family
MGAS9429_Spy1222	COG0497	DNA recombination
MGAS9429_Spy1223	COG1438	arginine binding
MGAS9429_Spy1224	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MGAS9429_Spy1229	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS9429_Spy1233	COG0765	amino acid transport
MGAS9429_Spy1234	COG4703	Protein of unknown function (DUF1797)
MGAS9429_Spy1235	COG0542	response to heat
MGAS9429_Spy1236	COG0494	nUDIX hydrolase
MGAS9429_Spy1239	COG3599	regulation of cell shape
MGAS9429_Spy1240	COG2302	S4 RNA-binding domain
MGAS9429_Spy1243	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MGAS9429_Spy1251	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MGAS9429_Spy1252	COG1940	carbohydrate kinase activity
MGAS9429_Spy1254	COG0783	Belongs to the Dps family
MGAS9429_Spy1257	COG4470	Protein conserved in bacteria
MGAS9429_Spy1259	COG1609	Transcriptional regulator
MGAS9429_Spy1260	COG3480	Lon protease (S16) C-terminal proteolytic domain
MGAS9429_Spy1262	COG0742	ribosomal rna small subunit methyltransferase
MGAS9429_Spy1264	COG0549	Belongs to the carbamate kinase family
MGAS9429_Spy1265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS9429_Spy1266	COG1288	antiporter activity
MGAS9429_Spy1274	COG2972	Histidine kinase
MGAS9429_Spy1277	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS9429_Spy1278	COG0785	Cytochrome C biogenesis protein
MGAS9429_Spy1279	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS9429_Spy1280	COG1518	maintenance of DNA repeat elements
MGAS9429_Spy1291	COG1605	Chorismate mutase
MGAS9429_Spy1291	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MGAS9429_Spy1296	COG2226	methyltransferase
MGAS9429_Spy1298	COG3250	beta-galactosidase activity
MGAS9429_Spy1299	COG4753	response regulator
MGAS9429_Spy1299	COG2207	Transcriptional regulator
MGAS9429_Spy1300	COG2972	Histidine kinase
MGAS9429_Spy1303	COG0395	ABC-type sugar transport system, permease component
MGAS9429_Spy1307	COG2723	6-phospho-beta-galactosidase activity
MGAS9429_Spy1308	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MGAS9429_Spy1311	COG0383	alpha-mannosidase activity
MGAS9429_Spy1322	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MGAS9429_Spy1323	COG1739	Uncharacterized protein family UPF0029
MGAS9429_Spy1325	COG1098	S1 RNA binding domain
MGAS9429_Spy1327	COG2197	response regulator
MGAS9429_Spy1328	COG4585	Histidine kinase
MGAS9429_Spy1330	COG0515	serine threonine protein kinase
MGAS9429_Spy1330	COG2815	serine threonine protein kinase
MGAS9429_Spy1332	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MGAS9429_Spy1332	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS9429_Spy1334	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MGAS9429_Spy1338	COG0583	DNA-binding transcription factor activity
MGAS9429_Spy1340	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS9429_Spy1342	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS9429_Spy1343	COG2610	gluconate transmembrane transporter activity
MGAS9429_Spy1344	COG2610	gluconate transmembrane transporter activity
MGAS9429_Spy1347	COG0116	Belongs to the methyltransferase superfamily
MGAS9429_Spy1351	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS9429_Spy1352	COG3579	cysteine-type endopeptidase activity
MGAS9429_Spy1354	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MGAS9429_Spy1355	COG1113	amino acid transport
MGAS9429_Spy1356	COG0492	ferredoxin-NADP+ reductase activity
MGAS9429_Spy1358	COG1126	abc transporter atp-binding protein
MGAS9429_Spy1361	COG0513	Belongs to the DEAD box helicase family
MGAS9429_Spy1363	COG0768	penicillin binding
MGAS9429_Spy1371	COG1131	(ABC) transporter
MGAS9429_Spy1376	COG0446	pyridine nucleotide-disulphide oxidoreductase
MGAS9429_Spy1377	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS9429_Spy1385	COG1755	Isoprenylcysteine carboxyl methyltransferase
MGAS9429_Spy1387	COG0656	L-ascorbic acid biosynthetic process
MGAS9429_Spy1389	COG1283	sodium-dependent phosphate transmembrane transporter activity
MGAS9429_Spy1394	COG0561	phosphatase activity
MGAS9429_Spy1395	COG2860	membrane
MGAS9429_Spy1398	COG1105	Belongs to the carbohydrate kinase PfkB family
MGAS9429_Spy1407	COG2217	Heavy metal translocating P-type atpase
MGAS9429_Spy1413	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MGAS9429_Spy1414	COG0195	Participates in both transcription termination and antitermination
MGAS9429_Spy1418	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS9429_Spy1442	COG1783	phage Terminase large subunit
MGAS9429_Spy1469	COG4974	Belongs to the 'phage' integrase family
MGAS9429_Spy1472	COG4473	ABC transporter
MGAS9429_Spy1473	COG1131	(ABC) transporter
MGAS9429_Spy1474	COG0537	adenosine 5'-monophosphoramidase activity
MGAS9429_Spy1476	COG1316	TRANSCRIPTIONal
MGAS9429_Spy1478	COG0802	atpase or kinase
MGAS9429_Spy1479	COG2252	PERMEase
MGAS9429_Spy1480	COG0561	phosphatase activity
MGAS9429_Spy1482	COG3715	PTS system
MGAS9429_Spy1483	COG3716	PTS system mannose fructose sorbose family IID component
MGAS9429_Spy1488	COG0439	Biotin carboxylase
MGAS9429_Spy1491	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MGAS9429_Spy1492	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS9429_Spy1493	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MGAS9429_Spy1498	COG1024	Enoyl-CoA hydratase
MGAS9429_Spy1501	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MGAS9429_Spy1505	COG0588	phosphoglycerate mutase activity
MGAS9429_Spy1506	COG2261	transglycosylase associated protein
MGAS9429_Spy1511	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MGAS9429_Spy1511	COG0574	Belongs to the PEP-utilizing enzyme family
MGAS9429_Spy1512	COG1335	isochorismatase
MGAS9429_Spy1514	COG0436	Aminotransferase
MGAS9429_Spy1516	COG0561	phosphatase activity
MGAS9429_Spy1517	COG0252	asparaginase activity
MGAS9429_Spy1521	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MGAS9429_Spy1524	COG1129	ABC transporter
MGAS9429_Spy1527	COG1132	(ABC) transporter
MGAS9429_Spy1528	COG4988	ABC transporter
MGAS9429_Spy1529	COG1120	ATPase activity
MGAS9429_Spy1530	COG1120	ATPase activity
MGAS9429_Spy1535	COG1388	LysM domain
MGAS9429_Spy1535	COG3942	CHAP domain
MGAS9429_Spy1539	COG5433	transposase activity
MGAS9429_Spy1541	COG1482	cell wall glycoprotein biosynthetic process
MGAS9429_Spy1543	COG1940	carbohydrate kinase activity
MGAS9429_Spy1546	COG1263	PTS System
MGAS9429_Spy1546	COG2190	(PTS) system
MGAS9429_Spy1546	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS9429_Spy1547	COG1621	beta-fructofuranosidase activity
MGAS9429_Spy1548	COG1609	Transcriptional regulator
MGAS9429_Spy1552	COG2131	deaminase
MGAS9429_Spy1553	COG0006	proline dipeptidase activity
MGAS9429_Spy1562	COG1194	a g-specific adenine glycosylase
MGAS9429_Spy1564	COG3118	belongs to the thioredoxin family
MGAS9429_Spy1570	COG0681	Belongs to the peptidase S26 family
MGAS9429_Spy1571	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MGAS9429_Spy1574	COG1882	Formate acetyltransferase
MGAS9429_Spy1575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MGAS9429_Spy1578	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS9429_Spy1580	COG2814	Major facilitator Superfamily
MGAS9429_Spy1581	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MGAS9429_Spy1586	COG0789	Transcriptional regulator
MGAS9429_Spy1589	COG2081	HI0933 family
MGAS9429_Spy1591	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MGAS9429_Spy1592	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MGAS9429_Spy1597	COG0456	acetyltransferase
MGAS9429_Spy1598	COG1214	PFAM Peptidase M22, glycoprotease
MGAS9429_Spy1601	COG0174	glutamine synthetase
MGAS9429_Spy1602	COG0789	Transcriptional regulator
MGAS9429_Spy1605	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MGAS9429_Spy1616	COG0668	transmembrane transport
MGAS9429_Spy1618	COG4720	Psort location CytoplasmicMembrane, score
MGAS9429_Spy1619	COG0351	phosphomethylpyrimidine kinase
MGAS9429_Spy1623	COG1929	Belongs to the glycerate kinase type-1 family
MGAS9429_Spy1624	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MGAS9429_Spy1630	COG0577	efflux transmembrane transporter activity
MGAS9429_Spy1631	COG1136	(ABC) transporter
MGAS9429_Spy1632	COG1132	(ABC) transporter
MGAS9429_Spy1636	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS9429_Spy1636	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS9429_Spy1637	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS9429_Spy1648	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MGAS9429_Spy1653	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS9429_Spy1655	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MGAS9429_Spy1659	COG1045	serine acetyltransferase
MGAS9429_Spy1662	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MGAS9429_Spy1665	COG3711	transcriptional antiterminator
MGAS9429_Spy1671	COG0431	NADPH-dependent FMN reductase
MGAS9429_Spy1672	COG1846	Transcriptional regulator
MGAS9429_Spy1676	COG4589	Belongs to the CDS family
MGAS9429_Spy1679	COG1862	Preprotein translocase
MGAS9429_Spy1681	COG1523	belongs to the glycosyl hydrolase 13 family
MGAS9429_Spy1685	COG3842	ATPase activity
MGAS9429_Spy1693	COG1263	PTS System
MGAS9429_Spy1693	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS9429_Spy1693	COG2190	(PTS) system
MGAS9429_Spy1694	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MGAS9429_Spy1702	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MGAS9429_Spy1703	COG0512	Glutamine amidotransferase of anthranilate synthase
MGAS9429_Spy1704	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MGAS9429_Spy1711	COG0601	transmembrane transport
MGAS9429_Spy1713	COG1122	ATPase activity
MGAS9429_Spy1717	COG0803	Belongs to the bacterial solute-binding protein 9 family
MGAS9429_Spy1718	COG5433	transposase activity
MGAS9429_Spy1720	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MGAS9429_Spy1720	COG1404	Belongs to the peptidase S8 family
MGAS9429_Spy1724	COG1196	nuclear chromosome segregation
MGAS9429_Spy1725	COG3711	transcriptional antiterminator
MGAS9429_Spy1728	COG3942	CHAP domain
MGAS9429_Spy1728	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS9429_Spy1729	COG3850	Histidine kinase
MGAS9429_Spy1729	COG5002	protein histidine kinase activity
MGAS9429_Spy1730	COG0745	RESPONSE REGULATOR receiver
MGAS9429_Spy1731	COG0577	efflux transmembrane transporter activity
MGAS9429_Spy1732	COG1136	(ABC) transporter
MGAS9429_Spy1749	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MGAS9429_Spy1754	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS9429_Spy1755	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS9429_Spy1756	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS9429_Spy1757	COG2390	Transcriptional regulator
MGAS9429_Spy1758	COG1349	DNA-binding transcription factor activity
MGAS9429_Spy1759	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS9429_Spy1763	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS9429_Spy1766	COG0564	pseudouridine synthase activity
MGAS9429_Spy1773	COG0542	response to heat
MGAS9429_Spy1774	COG4463	regulation of RNA biosynthetic process
MGAS9429_Spy1778	COG0450	alkyl hydroperoxide reductase
MGAS9429_Spy1782	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MGAS9429_Spy1784	COG3404	Formiminotransferase-cyclodeaminase
MGAS9429_Spy1787	COG0531	amino acid
MGAS9429_Spy1793	COG3590	peptidase
MGAS9429_Spy1794	COG0366	Alpha amylase catalytic
MGAS9429_Spy1795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS9429_Spy1795	COG1263	PTS System
MGAS9429_Spy1796	COG2188	Transcriptional regulator
MGAS9429_Spy1797	COG1733	regulation of RNA biosynthetic process
MGAS9429_Spy1798	COG2514	catechol 2,3-dioxygenase activity
MGAS9429_Spy1800	COG0602	queuosine metabolic process
MGAS9429_Spy1802	COG0673	inositol 2-dehydrogenase activity
MGAS9429_Spy1804	COG1328	CTP reductase activity
MGAS9429_Spy1809	COG1393	Belongs to the ArsC family
MGAS9429_Spy1812	COG0519	Catalyzes the synthesis of GMP from XMP
MGAS9429_Spy1814	COG2814	Major facilitator Superfamily
MGAS9429_Spy1821	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS9429_Spy1822	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS9429_Spy1823	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS9429_Spy1842	COG1511	domain protein
MGAS9429_Spy1846	COG0305	Participates in initiation and elongation during chromosome replication
MGAS9429_Spy1852	COG1760	l-serine dehydratase
MGAS9429_Spy1853	COG1760	l-serine dehydratase
MGAS9429_Spy1854	COG0741	lytic transglycosylase activity
MGAS9429_Spy1855	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MGAS9429_Spy1858	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MGAS9429_Spy1860	COG0612	Peptidase, M16
MGAS9429_Spy1871	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS9429_Spy1872	COG0488	(ABC) transporter
MGAS9429_Spy1877	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MGAS9429_Spy1878	COG1475	DNA binding