LOCUS MK448431 12881 bp DNA linear PHG 10-APR-2019 DEFINITION Streptococcus satellite phage Javan325, complete genome. ACCESSION MK448431 VERSION MK448431.1 KEYWORDS . SOURCE Streptococcus satellite phage Javan325 ORGANISM Streptococcus satellite phage Javan325 Viruses; unclassified bacterial viruses. REFERENCE 1 (bases 1 to 12881) AUTHORS Rezaei Javan,R., Ramos-Sevillano,E., Akter,A., Brown,J. and Brueggemann,A.B. TITLE Prophages and satellite prophages are widespread among Streptococcus species and may play a role in pneumococcal pathogenesis JOURNAL Unpublished REFERENCE 2 (bases 1 to 12881) AUTHORS Rezaei Javan,R., Ramos-Sevillano,E., Akter,A., Brown,J. and Brueggemann,A.B. TITLE Direct Submission JOURNAL Submitted (25-JAN-2019) Nuffield Department of Medicine, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford, Oxfordshire OX1 3SY, United Kingdom COMMENT ##Assembly-Data-START## Assembly Method :: Velvet v. 1.2.10 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..12881 /organism="Streptococcus satellite phage Javan325" /proviral /mol_type="genomic DNA" /host="Streptococcus mitis P-37" /db_xref="taxon:2558638" gene complement(1..1164) /locus_tag="JavanS325_0001" CDS complement(1..1164) /locus_tag="JavanS325_0001" /codon_start=1 /transl_table=11 /product="integrase/recombinase" /protein_id="QBX09209.1" /translation="MNITEYKKKNGTIVYRASVYLGVDKLTGKKARTTVTANTKKGIK IKAREAVNAFASNGYTVKDKPIITTYKELVKVWWDSYKNTVKPNTRQSMDGLVRVHLL PVFGDYKLDKLTTPILQQQVNKWADKANKGEKGAFANYSLLHNMNKRILKYGVAIQVI QYNPANDVIVPRKQQKEKSTVKYLDNKELKQFLDYLDSLDQSNYENLFDVVLYKTLLA TGCRISEALALEWSDIDLENGVISINKTLNRYQEINSPKSNAGYRDIPIDRTTLLLLK QYKNRQQIQSWKLGRTETVVFSVFTEKYAYACNLRKRLNNHFENAGVTNVSFHGFRHT HTTMMLYAQTSPKDVQYRLGHSNLLVTENVYWHTNQENAKKAVSNYETAINNL" gene complement(1560..1994) /locus_tag="JavanS325_0002" CDS complement(1560..1994) /locus_tag="JavanS325_0002" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX09210.1" /translation="MKFQQGEVYLINFPQKGGNEFYGKHYAIILTIPDKADGTLLVAP LTGKKSGKKYRGGITIENSKYQNTPSKPKAYAYVRKIQEIDKRKIVYKTKKKTDSDGQ VMLDAAGKELYDKVYRPAYKLDTNDHKKLLDKIKEVLGLDLY" gene complement(2441..3511) /locus_tag="JavanS325_0003" CDS complement(2441..3511) /locus_tag="JavanS325_0003" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX09211.1" /translation="MELKEIIENIKKEIPVLDSSSDYWLVRANSGEYYTDFNLNGYIG IGWNEITLEDIRRADNNSNVLKEILKEKLTFQDDLEPSENKYGITAGQLLRFVNNIKK NDIVVVPSEGSERFLVGKVIGPLYELDQYELEQYKSEELTHSRSDFAKRWKVHWLGWF NRSDADSALYKMIYSHATLSNINDYKPFINRALFPCYIEDEKLYISYHVTEEKDIQGV YLGQFVYQYSLLTRLLFPETRVDSKINVQSEGIIELITHTVNYGLIISMILGGAIVLT SGGKLKVMGLELEVPGLINTYQDYQKNKLDRIKQAKELADELGVPISELGIRIPRKLT AAIENKSVVQQTTSNPPGKFEE" gene complement(3593..4039) /locus_tag="JavanS325_0004" CDS complement(3593..4039) /locus_tag="JavanS325_0004" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX09212.1" /translation="MKKLLTTSAILLSATVLVACSNNQSAAKDGSEKPKTEQTKANDK PASKKATSLDDFKKALESNDFTIKEEISKEASLIQAESGKGFILEDDTAVEVYEYYDK NPMFEEAKKEKELIGHPAYIYGNYVILVLNATDSKDKILDSFKGFE" gene complement(4096..4734) /locus_tag="JavanS325_0005" CDS complement(4096..4734) /locus_tag="JavanS325_0005" /codon_start=1 /transl_table=11 /product="DNA-binding protein" /protein_id="QBX09213.1" /translation="MNRLKELRQEKKLTQQELANEIGVTKRTYIYWEKGERQIKTDKA KQLADFFGVPVGYLLGYSSIPPLLENQLSEEEKEELRKNPQLANELSDLAWQKYTVKM NAIENKKHKPASITEIQNRLNSRYGTNVHGDSAFLAFSVGAGDHDYEFLRWFDGLLDI DSIDGTNTADLLYKYIILDDDSKRIITELIEKLPQIKADSILVTNHNDDETN" gene 4968..5153 /locus_tag="JavanS325_0006" CDS 4968..5153 /locus_tag="JavanS325_0006" /codon_start=1 /transl_table=11 /product="HTH DNA-binding protein" /protein_id="QBX09214.1" /translation="MRVILAKKRLKVADVARETGLSKSTLTALYYERAKNPSLDTLKK VSSYLGVTLDEFLDTKD" gene 5275..5790 /locus_tag="JavanS325_0007" CDS 5275..5790 /locus_tag="JavanS325_0007" /note="FIG01120104: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX09215.1" /translation="MNNTQVYQAQTTNHGIARALGEEIRMITDVEETNYNGHGEIIVE YTSDVALTKLFDRIKSLYEKGESYETKPFLHFKVLEDDLEPKPGVFTVKEVMDFFGNL KQQKRGKEMNFKEFKTWLDNAVSVAEAMALPENKGVLDDLIENTANNLAFISELVESR QLIYRKPRHED" gene 6173..6466 /locus_tag="JavanS325_0008" CDS 6173..6466 /locus_tag="JavanS325_0008" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX09216.1" /translation="MTTKKATSSQQVLLSAKKLAELGNELTDIMNVLEMNNLALEGLE FALQKDTTTFLWLAKKYTDTAYAQNEKLYDRLNEIAFLLLNNDDAKELEAYHD" gene 6429..6563 /locus_tag="JavanS325_0009" CDS 6429..6563 /locus_tag="JavanS325_0009" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX09217.1" /translation="MTTLKSWRHTMTKDIKEMAQAEDDLLYMEQPKQAEFIKNYKARA " gene 6565..6768 /locus_tag="JavanS325_0010" CDS 6565..6768 /locus_tag="JavanS325_0010" /note="FIG01116276: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX09218.1" /translation="MNELDLTNTQALIFSVVLIALLVYLNHRDRKKSAQFERENQQTI ETPSEDLNPYYGRYIQLAGKIHN" gene 6782..7048 /locus_tag="JavanS325_0011" CDS 6782..7048 /locus_tag="JavanS325_0011" /note="FIG01114073: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX09219.1" /translation="MQLLSREAELELLEKVGNHLAKRMELEKQRDDNWDLISRPDLLK KLGISGTTLNNWEKEGLKPLRSPFESSKKVYYRKSDVYNFLAVD" gene 7057..7572 /locus_tag="JavanS325_0012" CDS 7057..7572 /locus_tag="JavanS325_0012" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX09220.1" /translation="MRIIELTISVEKMPLFGFLKSNPTQVWKNGEHYKFTYYEPVDEA LTGFQYKGLYVSIKDENEVVEGWGLVRNLDIAMASPDLLTILKDLEVNKLTEQRQGLG VELKGWIFDLICNGIYTRYETSLFVRLLFVNGYSFNQLVDLFSAIVKRKDLASYFLEV ARIFYKEVAFE" gene 7565..9019 /locus_tag="JavanS325_0013" CDS 7565..9019 /locus_tag="JavanS325_0013" /codon_start=1 /transl_table=11 /product="virulence-associated protein E" /protein_id="QBX09221.1" /translation="MSSNEIVKKIIEEDKQKVPPEVVDLTQARETNEEHNSLDLTPKT KGKGFVITLDNLKKILNGDSKLKGAIQYNVFTYEIDVTRPMKLNGRTLSGAIDDLIIR EIRAYIATKYKLDYKKSDIADILEVVAGEHSYNPLKDYLESCENEYKELVNQRDPFDI LRHYLNIKDDEYNRIIVDLFFRGAVAKVFDPSIKFDFVLDLTGRQGVGKTQFFEGLFT HKYFTTVETFTDKDDKARMVRNWCVFDDEMVASKKASFSELKKFITETKLEFRPPYAS SDRRLPKSFIIVRATNDHDYLNDLTGERRFLVAEVYKDTAYKGRKWTEKDRRAFWGAM VVAWKSNKSLTLTDEQEKLVNEVRSRYKFVDEILEDVERYLETPYPKNMYQFPTTDST RHYYIHDMMNHGYHMGTNGVEVHLDTEKYGELVERDKVVVNLFFSEVYLNNSPNPKDK NKVKKIMQNKEGWEYRESLRFGKSVKRGFAKIKK" gene 9377..9574 /locus_tag="JavanS325_0014" CDS 9377..9574 /locus_tag="JavanS325_0014" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX09222.1" /translation="MAMNICQRVTRLEETVERISEVLDGFIENANYNSSVNNVNVIKI AEKFEQVFEELDELKAVHDKH" gene 9659..9928 /locus_tag="JavanS325_0015" CDS 9659..9928 /locus_tag="JavanS325_0015" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX09223.1" /translation="MTLKAFSETAPKHTFTYEFGDLEDAQIAGLALFGFMRGTYLVPA IKLRYKENGTLIAEYLEDNNLDINFKRICEVFKNEENPIDEEVEE" gene 10025..10690 /locus_tag="JavanS325_0016" CDS 10025..10690 /locus_tag="JavanS325_0016" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX09224.1" /translation="MADTQNTNNIEQAQKRQELAQKMDKALDKITKEVNALITQNENA IAEAEREKTQLLQDQANAQREHDEAVDEVDKDKLRNAKDNLWIAESKLKKNAKKLEDL HNETLMSLEDFKAKIDELDSTVDKKHKALYDKAVDLLREIDQIDDEFRADSDKLQALY HAMAYKVGKGKREFTFSTGGSIISPADGRVRYEPVHPVEPFLRDVYVRAFGNTYNDVK GHF" gene 10757..10900 /locus_tag="JavanS325_0017" CDS 10757..10900 /locus_tag="JavanS325_0017" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX09225.1" /translation="MEEHQQAHPEYERYNFKYIEDGDAIGAIIDYNVEESVLKAEKEQ DNA" gene 10949..11449 /locus_tag="JavanS325_0018" CDS 10949..11449 /locus_tag="JavanS325_0018" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX09226.1" /translation="MTDKLTQRQEKFVQGLVAGLSQRKAYKEAYNAQKMADSTIDSRA SKLLKEYKVNTRYRELLKEFSNRALWSREQAFNEYEWLKNKAKSEIIESGLKPSNFNA FLSALHGMNNSAFRDLELLDEKLRAEISVIKSNIHQETPVKDDKFIEAMSAMVESVWE DEIQKE" gene 11530..11922 /locus_tag="JavanS325_0019" CDS 11530..11922 /locus_tag="JavanS325_0019" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX09227.1" /translation="MELDKFKTMMNVRERMTYFLRFQRMAGSENQVTIDEEAWELVLP DQWNLSGEHEKAIREGLEIFAQDINSIENKRARKYFIIHYCYMRKKTVSECLEIAGTK STSYHRYKQIAILNFARIHQNGELEVYK" gene complement(12026..12241) /locus_tag="JavanS325_0020" CDS complement(12026..12241) /locus_tag="JavanS325_0020" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX09228.1" /translation="MELKEFNNKVVRITDIDGQIFKGVALYEDKDVHDEEFDGLSVNS GTRWIKLFENEIKEIEITDKINQSKNP" gene complement(12522..12881) /locus_tag="JavanS325_0021" CDS complement(12522..12881) /locus_tag="JavanS325_0021" /note="conserved hypothetical protein NMA0318" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX09229.1" /translation="MDRSQKTWEIDGYLWLNCPVCGTEVMDYDICDVCRWQNTGIINI DGGPNKMTLAEAKEAYARRKIVKIREFDTVLLKNGQTATIVEKLSEDTFIADIGDSPK DWDTITITINDIEKVVY" ORIGIN 1 ttataaatta ttgatggctg tttcataatt tgagacagct ttttttgcat tctcttggtt 61 tgtatgccag taaacatttt cagtcactaa taagttagag tgtcccaatc tgtattggac 121 atctttaggg ctagtctgag cgtacaacat catagtggta tgtgtatggc ggaaaccgtg 181 gaatgataca tttgttacac cagcattctc aaaatgatta tttaggcgtt tgcgtaagtt 241 gcaagcataa gcatatttct ctgtaaatac tgagaataca actgtttcag ttcggcctaa 301 tttccaagac tgaatttgtt gacggttttt gtattgttta agtaaaagta aagtggttct 361 gtctattggt atatcacgat aaccagcgtt tgatttaggt gagtttattt cttgatagcg 421 gtttagtgtc ttattgatac tgataacacc gttttctagg tcaatatcag accattcaag 481 agccagagcc tcactaatac gacacccagt ggccaataaa gtcttatata ggacaacatc 541 aaataaattt tcataattgg attgatccag agaatctaaa taatcaagaa actgttttaa 601 ttctttgttg tctaagtatt ttacagtaga tttttctttt tgctgtttgc gtggaacgat 661 gacatcgtta gctggattgt attgtattac ctgtatagct acgccatact tcaaaatacg 721 cttattcatg ttatggagta aggagtagtt agcaaacgcc cctttttcgc ccttattggc 781 tttgtcagcc catttgttta cttgctgttg aagaataggc gtggttagct tatctagctt 841 gtaatcgcca aatacaggca ataaatgaac tctaaccaat ccatccatag attgacgagt 901 attgggctta actgtattct tgtaactatc ccaccaaact tttaccagtt ctttgtatgt 961 tgtgattatt ggtttatctt taactgtata gccgtttgaa gcaaaagcat tgacagcctc 1021 tcttgctttt attttaatcc cctttttagt gttggctgta actgtagttc tagccttttt 1081 ccctgtaagt ttatcaactc caagatacac gcttgctcgg tatacgatag tcccgttttt 1141 ctttttgtat tctgtaatat tcatggtttt tactcctttt ccatcagcag gcaagcaatt 1201 agaaaaggtt ttgagtttat accatgcgag gggctacgag aaacccctta ttttcgattt 1261 taagcagtca gacgataaat aatgccagag catgaaaaaa tgcggatatg gggcttatat 1321 aggcttgaag cttgaggaag cccgagaatc cacgcgcctt tgttggtata atcggacttt 1381 tcggctaccc taaaagaaaa atattaggga tgaggttcca gggattttta ataaactaaa 1441 agcccaactc ataagagcag ggctagagat gtcctcttgg gacagtatca tctattttgt 1501 cgtcaagcga ctttatgatt taattctaac cctaatttta aaaaaagtca attttttatt 1561 taatataaat ctagtccaag aacttctttt atcttgtcta atagtttttt atggtcgttt 1621 gtatctagct tataagctgg tctataaact ttatcatata actcttttcc cgctgcatct 1681 agcattactt gtccatcact atcagtcttt ttctttgttt tatagacgat tttccgtttg 1741 tctatttctt ggatttttcg gacataagca taggcttttg gcttggaagg agtgttttga 1801 tatttactat tttcaatcgt gataccacca cgatatttct ttcctgattt tttaccagtt 1861 aaaggtgcta ctaggagtgt tccatcagct ttgtcaggaa ttgttaagat gatagcgtag 1921 tgttttccgt aaaattcatt cccacctttt tgtgggaagt tgattagata aacttcgcct 1981 tgttgaaatt tcatataatg ctccagataa taaaataagg tgtacctctt agaagtacac 2041 cagaccgttt tgtccttgac gaacaaggct ttataagtaa atatcgtatc cttgacgaac 2101 aaggcttttg acattatcag tgtactgctt ttttaacttt ttgtcaagtt ttttgttaaa 2161 tttattttta ttattgtcaa ctatttcatt ttggaaacag ttgtttttac ttgtttatgt 2221 tataattatt taaaaagaga gaggagaaaa aaatatgtta aaaaaagagt taaaaaattt 2281 tattgtatcg acatttatat ttctcttaat tttcaagatt tttttctcaa taactacgat 2341 ttacatcaca aatagctatc tttcaatagc gataactaca cttgtcacat ttttattaaa 2401 aaaatttatt tctttcgagt ctaactgatg ttagactttt ttattcctca aacttacctg 2461 gtggattact agtagtctgt tgtacaactg atttgttttc tatagcagct gttagttttc 2521 tcggaatacg aattcctaat tcagatattg gtacaccgag ttcatcagct agttcttttg 2581 cttgcttaat ccggtcgagt ttgttttttt gatagtcttg atacgtattt attaatcccg 2641 ggacttcaag ttctaatccc ataaccttta gtttcccccc acttgtcaga acaattgctc 2701 caccaagtat cattgaaatt ataagtccat agtttacagt atgcgtaata agttctataa 2761 taccctcgga ctgtacattt atttttgaat ctactcgtgt ttcagggaaa agcaaccttg 2821 ttaatagaga atattgataa acaaattgac ccaaataaac cccttgaata tctttttctt 2881 ctgttacatg gtagctaata tatagttttt cgtcttcaat atagcaaggg aaaagtgcgc 2941 ggttaatgaa cggtttataa tcatttatat ttgatagtgt tgcatgagaa taaatcattt 3001 tatacaatgc gctgtctgca tcggaacgat taaaccatcc taaccaatgg actttccacc 3061 tttttgcaaa gtcagatcga ctatgcgtca actcttcact tttgtattgt tcaagctcat 3121 attgatcgag ttcgtaaagt ggtccaataa ctttaccgac taaaaatcgt tcagatcctt 3181 cagatgggac aacaactata tcgtttttct taatgttatt tacaaagcga agcagttggc 3241 ctgcagtgat accatatttg ttttcagatg gttctaagtc atcttgaaat gttagttttt 3301 cttttaaaat ttcttttaat acattggagt tattatctgc tcgtctaata tcttcaaggg 3361 taatctcatt ccatccaata cctatatagc catttagatt aaaatccgta taatattctc 3421 cagagttagc acgcactagc caataatcac tagaagaatc taaaacaggg atttcttttt 3481 ttatattttc tataatttct tttaattcca ttgtaattat ctactttctt ttttatttcc 3541 ctctatacac gctcagactg gccaaacttt gagagtgtgg ggattttttt atttattcaa 3601 atcctttgaa actatctaaa atcttatctt ttgagtctgt agcattaagc actaaaataa 3661 cataattccc gtagatataa gcagggtgtc caatcaactc tttttctttc ttagcttctt 3721 caaacattgg gtttttatcg taatattcgt aaacctctac agcagtatca tcttctaaga 3781 tgaaaccttt ccctgattcg gcttgaataa gactagcttc ttttgagatt tcctctttga 3841 ttgtgaagtc attactttct agcgcttttt taaaatcgtc taagctagta gcctttttag 3901 aagcaggttt gtcatttgct ttagtttgct cggtttttgg tttctccgag ccatctttgg 3961 cagccgattg gttgttagaa catgctacta gaactgtagc actaagcaag atagctgatg 4021 ttgttagtag ttttttcata gataatctcc tttttatata tactgataat ttctcaaata 4081 gattaaaatt ttagtttaat ttgtttcatc atcgttgtga tttgttacta gaatagaatc 4141 agcttttatt tgtggtaatt tttcaataag ttcggttatt atccgtttgc tatcatcatc 4201 taagataatg tatttataaa gcagatcagc ggtattagtt ccgtcaatcg aatcaatatc 4261 aagtaacccg tcaaaccaac gtagaaattc ataatcgtga tccccagcac caactgaaaa 4321 tgcgagaaat gcagaatctc catgaacgtt cgttccgtat cggctattaa gtcgattctg 4381 tatttctgta atactagcag gtttgtgttt cttgttttcg atggcgttca tttttactgt 4441 atacttttgc caagccaagt ctgataattc atttgccaat tgcgggtttt ttcttaactc 4501 ttctttttcc tcctcggaca attggttttc taagagcgga ggaatagaac tatagcctag 4561 caggtatcca acaggtacgc caaaaaaatc agctagttgt ttcgctttgt ctgtttttat 4621 ttggcgctca cctttttccc aatatatata agttcgtttt gtgaccccta tttcattcgc 4681 taactcttgc tgagttagct ttttttcttg tcttagttct ttcaatctat tcatttatat 4741 aaacaccttt caaatgtatt atatcacgat taatttcaaa gggtgcaaaa aaagtgcaat 4801 tatttttaat aattctcttg acattgcaca ataattgcaa tataatgagt ttgtcaacta 4861 gagttgaaca aaaattacac caatctccag agcaacactt ttcaatctat tctactggag 4921 gtcgatttta aagataatgg aaaggggtaa ggtatttgaa aaataatatg cgtgttattt 4981 tagcaaagaa gcgcttgaag gtggcagatg ttgcaagaga aacagggcta tcaaaaagca 5041 ctttaacggc tttgtactat gaacgtgcaa agaatccaag tcttgataca ttgaaaaaag 5101 tatctagtta cttgggagtt acgctggatg aatttctaga tacgaaagat tagaaaggag 5161 cgacccaatc gcaatacttc aatacattta caagtttctc atgtggtgct ttaccactgg 5221 ggattgacct gctcggaaga aatatccgac ctagaacata aaggagaaaa caacatgaac 5281 aacacacaag tatatcaagc acaaacaact aaccacggta tcgctagagc attgggcgaa 5341 gaaattcgta tgatcaccga cgttgaagag acaaattaca atggacacgg tgaaatcatt 5401 gttgagtaca ccagtgatgt tgcattgaca aaactatttg accgtattaa atcactttac 5461 gaaaaaggcg aaagctacga aacaaaacca ttcttacatt ttaaagtatt ggaagatgat 5521 ttggaaccaa aaccaggagt ttttactgtt aaagaggtta tggatttttt tgggaatttg 5581 aaacaacaaa aaaggggcaa agaaatgaac tttaaagaat ttaaaacatg gctagataat 5641 gccgtgagtg tggctgaagc tatggcatta cctgaaaaca aaggtgtgct tgacgacttg 5701 atagaaaata cggccaataa cctagctttt atctctgagt tagtggaaag tcgccaactg 5761 atttatagaa aacctagaca tgaagattaa aaacgacaac aaaaaaagtc acttgctcaa 5821 attttggtcg aggagagcaa gcgactggat caagagtata gatatttttc tatatctcaa 5881 ttataacaga aatcaactat tcaatcaata acaactaatg gcaggcaagc aattagaaaa 5941 gattttaaaa agcatagagc gccaactctt aaaactggta ctttctcacg ctctcaaaac 6001 tttggcgagt ctgagcgtga ggctagtggc aagaaaaact gtataagaaa caaccattca 6061 aaatccccac gctctcggtc ggcaaacttc tgagcgtgag gtatgtaaca ggaaaaaaag 6121 cattaaaagc catcgtggca agtataaaaa gatagaaaaa gaggtaaaaa acatgacaac 6181 aaaaaaagca acatcaagcc aacaagttct attatcggct aagaaactag cagaattagg 6241 gaacgaatta accgacatca tgaatgtttt agaaatgaat aacctagctc ttgaagggct 6301 tgagtttgca ctacagaaag atacaaccac attcttatgg cttgctaaaa aatacactga 6361 tacagcatac gcccagaatg aaaagctata cgatcgtcta aatgaaatag cctttttgct 6421 tttgaacaat gacgacgcta aagagctgga ggcataccat gactaaagat attaaagaaa 6481 tggcacaagc cgaagacgac ttgctgtata tggaacaacc taaacaagcg gaatttatca 6541 agaactataa ggcgagggca taacatgaac gaactagatt taaccaacac acaggcactt 6601 atcttttccg tggtactgat tgccttactg gtctatctaa accaccgaga ccgcaaaaaa 6661 agcgcacaat ttgagcgaga aaaccaacag acgatagaaa cacctagcga ggatttaaac 6721 ccttactacg ggcgttatat ccagcttgca ggtaagattc ataattagaa aggggtgtaa 6781 tatgcaacta ttatcaagag aagcagaact tgaattactg gagaaagtgg gaaatcactt 6841 agctaaaagg atggaacttg aaaagcaacg tgatgataac tgggacttga tttctaggcc 6901 tgacttactc aaaaaacttg gtattagtgg aactacgtta aataattggg aaaaagaagg 6961 tttgaaaccg ctacgttcac catttgaaag cagtaagaaa gtttattacc gcaagagtga 7021 tgtttacaat tttcttgcag tagattagga ggtgtaatga gaataataga gttgactata 7081 tcagttgaga aaatgcctct atttggcttt ctcaagtcaa atcctactca agtatggaag 7141 aatggggaac actacaaatt tacctattat gagcctgtag atgaggcttt gacgggtttt 7201 caatacaaag gtttatatgt gtctattaaa gatgaaaatg aggtagtaga gggctgggga 7261 ttggtcagaa atttggatat tgctatggcc agccctgact tgctgacgat cctgaaagat 7321 ttagaggtaa acaaattgac cgagcaacgg caggggcttg gagtggagtt aaaaggttgg 7381 attttcgacc tgatttgtaa tggcatttat accagatatg agacttcact ctttgtccga 7441 ctgctatttg tgaatggcta tagttttaat cagctggtgg atttgttttc tgcaatcgtc 7501 aagcggaaag acctagcaag ctatttttta gaagtagcaa gaatatttta taaggaggtg 7561 gcttttgagt agcaatgaaa ttgtaaaaaa aatcattgaa gaagataagc agaaagtacc 7621 gcctgaagtg gtggacttga ctcaagcaag ggagaccaac gaggaacaca atagcctaga 7681 tttaactcct aaaacaaaag gaaaaggctt tgtaatcacc ttggacaatc tcaagaagat 7741 tttaaatgga gatagcaagc taaaaggggc tatacagtac aacgtcttca cttatgaaat 7801 cgacgtgact agaccaatga agctaaacgg tagaaccttg agcggtgcaa tcgatgacct 7861 gattatcaga gagattaggg cttatattgc taccaagtac aagctggact ataaaaagtc 7921 tgatatagca gatattctgg aggtggtggc tggagagcat agctacaacc ccttaaaaga 7981 ctatctggaa tcatgcgaaa acgagtataa agagttagtg aatcagcgtg atccctttga 8041 tattttaagg cattatctca atatcaagga tgatgaatat aaccgtatta tcgtggactt 8101 gtttttccgt ggagcagttg ccaaggtatt tgacccctct atcaagtttg actttgtgct 8161 ggacttgact ggaaggcagg gagtggggaa gacccaattt tttgaggggc tattcactca 8221 taagtatttt acaaccgttg agaccttcac agacaaagac gacaaggcta gaatggtgag 8281 aaactggtgt gtatttgatg atgagatggt ggccagtaaa aaggctagtt tttcagaatt 8341 gaagaaattt atcacagaaa ccaagctaga gtttagaccg ccttacgctt caagtgacag 8401 acgattgcct aagagtttta ttatcgtgag ggcaaccaat gaccatgatt atttaaatga 8461 cttgacagga gaaaggcgct ttctggttgc agaagtctac aaggacaccg cttataaggg 8521 caggaagtgg acggaaaaag accgtagagc cttttggggt gctatggtgg tagcttggaa 8581 gtctaataaa tctttgacct tgacagacga gcaagaaaag ctagtaaacg aggttagaag 8641 ccgttacaag tttgtagatg aaatccttga ggatgttgag cgttatttag aaactcccta 8701 ccctaaaaat atgtatcaat tcccaacaac agacagtaca agacactact atattcatga 8761 catgatgaac cacggctacc atatgggcac taatggcgta gaggttcatc ttgatactga 8821 aaagtatggg gaactggtgg aaagggataa ggtggtagtt aatttattct tttctgaggt 8881 ttatttgaac aattccccta atcccaaaga taaaaataag gtaaagaaaa tcatgcaaaa 8941 caaagaaggc tgggaatata gagaatcttt aaggtttggt aaaagcgtca agcgcggatt 9001 tgctaaaata aaaaaataaa gtgtagacag tgtagccaaa agataaaaaa acggctacac 9061 tgaaaacctt tgatactgta agggtttcaa agaggtgtag acaagacgaa aaaaatggct 9121 acacccctaa acccttgata ttactgactt tttaatataa atgtagccaa aatatatatt 9181 ttataaaagt atagttaatt aaatatctaa tgcgttatat attatttttt tctgagatga 9241 aacggctaca cggctacaca agacctaaac ccttggagct gtagggcgga aggcgtagcc 9301 gctagatagt caaaaatggc tacactttgc ccgaaaccta aaataaaata gaaaatgaaa 9361 tgaaggagca aaccagatgg caatgaacat ttgtcaaaga gtgactagac tagaagaaac 9421 tgttgagcgg atcagtgagg tgttagatgg atttattgag aatgcgaact ataattcgtc 9481 ggtgaataat gtgaacgtga ttaaaatagc ggaaaagttt gagcaggtct ttgaagaact 9541 tgatgaacta aaagcagtac atgacaaaca ctaaaacaaa atggggtaga tagtaccgac 9601 ccccttgcga tggtgtaact actagtgaca cccttaaaac agaaagagga aaaacaacat 9661 gacattaaaa gcattttcag aaacagcacc aaaacataca tttacttatg aatttggaga 9721 cctagaagac gcacaaatag caggactagc gttatttgga tttatgagag gtacttatct 9781 agtgccagct attaaactaa gatataagga aaacggaacg cttatcgctg agtatttgga 9841 agataacaat ctagatatca actttaaacg tatttgtgaa gttttcaaga atgaagaaaa 9901 tccaatagat gaagaagttg aggaatagag tggagaggat gtaagcagat gaactacaat 9961 agagaccccg tgactggatc tagcactcta aacttaatca aacaatagaa aaggaaaaaa 10021 taagatggca gacacacaaa acacaaacaa cattgaacaa gcgcaaaaac gccaagaact 10081 agcccaaaaa atggataaag cactagataa aatcactaag gaagtaaacg cattgatcac 10141 acagaatgaa aatgcgattg ctgaggctga acgagaaaaa acacaattgc ttcaagatca 10201 agcgaacgcc caacgtgaac acgatgaagc ggttgatgaa gtagataaag acaagctacg 10261 caatgccaag gataatttat ggattgctga aagtaaatta aaaaagaatg ctaaaaagct 10321 ggaagacttg cacaatgaaa cacttatgag tcttgaagat tttaaggcaa aaatcgatga 10381 actagattca acggttgaca aaaagcataa ggcgctttat gataaagccg tggatttgct 10441 acgagagatt gaccagatcg atgacgaatt tagagcagat tcagataaac ttcaagccct 10501 ttaccatgct atggcttaca aagttgggaa aggtaagaga gagtttactt tcagtacagg 10561 gggatctatt atctctccag ccgatggaag ggttagatac gaaccagtcc atccagttga 10621 accattctta agagatgttt atgtgcgagc tttcggaaat acttacaacg atgtgaaggg 10681 acatttttaa aagatgaaga gacaaattag acacaaaatt gaaccagtac caacgattgt 10741 agaactcttt aaactaatgg aggagcacca gcaagcacat ccagagtacg agcgttataa 10801 ttttaaatac attgaagatg gtgatgctat tggtgcaatc attgactaca acgtagaaga 10861 atcagtatta aaagctgaga aagagcaaga taacgcttaa gacaagggga gttttttccc 10921 tttttgtcgc ttaaggaggt gaactaatgt gacagataag ttaacgcaaa gacaagaaaa 10981 atttgtccaa ggactagtgg ctggactatc tcaaagaaaa gcatataaag aggcatacaa 11041 cgcccaaaag atggctgata gtacgataga ttcaagggct agtaagttgc tgaaagagta 11101 caaggttaat acaaggtaca gagagttatt aaaagagttt tcaaaccgtg ctttgtggtc 11161 aagggagcag gcttttaatg agtatgaatg gctaaaaaat aaagctaaat ctgaaattat 11221 cgaaagtgga ttgaagccta gcaatttcaa tgcctttctt tctgctttgc atgggatgaa 11281 taatagcgct tttcgtgatt tggagttgct ggacgagaag ttgcgagcag aaatcagtgt 11341 gattaagagt aacatccatc aagaaactcc agttaaggat gataaattta tagaggccat 11401 gagcgcaatg gttgaatccg tctgggaaga tgagattcaa aaggaatagc cttagaatac 11461 gaaaaaaagc caaggcgctc cgcctcagct ataatctcaa atattattat atcacaaagg 11521 agcgaattaa tggagctgga taagtttaaa acgatgatga acgtcagaga gcggatgact 11581 tactttctac gtttccagag gatggcagga agtgaaaacc aagttacgat agatgaagag 11641 gcttgggaac ttgtcttacc tgatcagtgg aatttgagtg gtgaacatga aaaagcaatc 11701 cgtgaggggt tggaaatatt cgcccaagac atcaacagta tagagaacaa acgagccaga 11761 aaatacttta ttatccatta ttgctacatg agaaagaaaa cagtaagtga atgtttagaa 11821 attgctggga caaaatccac tagctaccac cgatacaaac agatagccat cttaaacttt 11881 gcgagaatcc accagaacgg agagttagaa gtgtataagt aagctgagat actgctagat 11941 tttgctaaaa gctatcgaga cggtgtttta gtggtgtata agcaaaacat atcttaggct 12001 taattaaaag cccttagaaa cgaatctaag ggttttttga ctggttgatt ttatcagtaa 12061 tttcaatttc cttgatttca ttttcaaaga gtttaatcca tctggttcca gaattaacgg 12121 ataacccatc aaattcttca tcgtggacat ctttgtcttc gtaaagagct acacctttaa 12181 atatttggcc atcaatatcg gtgattctga caaccttgtt attaaattct ttaagttcca 12241 taagtctctc ctttcgtggt actatagtct gttatattat tggaattccc ttaacatacg 12301 cttctttagc ctccgcaagt gtcattttat taggaccgcc atcgatatta aatgctcccg 12361 tattttgcca atgacaaaca tcacaaatat cataagtttc tactaaattt ccacatacgg 12421 ggcaatgcac atgttcccat ccgtcaatca ttattatatt cttttttata gtcttattca 12481 tttaaggtta ctcccaacac tatacaaata tattagctat ttcaatacac tactttttca 12541 atatcattga ttgtaattgt tatggtatcc cagtctttcg gggaatctcc tatgtcagca 12601 ataaaagtat cttcacttaa cttttcgaca attgtcgccg tttgaccgtt ttttaacaac 12661 actgtatcaa attctcgaat ttttacgatt tttctccttg cgtaagcttc tttggcttca 12721 gctagagtca tcttattcgg accaccgtct atatttataa tacctgtatt ttgccaacga 12781 cagacgtcac agatatcata gtccataact tcagttccgc aaacagggca atttaaccat 12841 aaatatccat caatttccca tgtcttttgt gatctatcca t //