LOCUS MK448506 11958 bp DNA linear PHG 10-APR-2019 DEFINITION Streptococcus satellite phage Javan462, complete genome. ACCESSION MK448506 VERSION MK448506.1 KEYWORDS . SOURCE Streptococcus satellite phage Javan462 ORGANISM Streptococcus satellite phage Javan462 Viruses; unclassified bacterial viruses. REFERENCE 1 (bases 1 to 11958) AUTHORS Rezaei Javan,R., Ramos-Sevillano,E., Akter,A., Brown,J. and Brueggemann,A.B. TITLE Prophages and satellite prophages are widespread among Streptococcus species and may play a role in pneumococcal pathogenesis JOURNAL Unpublished REFERENCE 2 (bases 1 to 11958) AUTHORS Rezaei Javan,R., Ramos-Sevillano,E., Akter,A., Brown,J. and Brueggemann,A.B. TITLE Direct Submission JOURNAL Submitted (25-JAN-2019) Nuffield Department of Medicine, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford, Oxfordshire OX1 3SY, United Kingdom COMMENT ##Assembly-Data-START## Assembly Method :: Velvet v. 1.2.10 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..11958 /organism="Streptococcus satellite phage Javan462" /proviral /mol_type="genomic DNA" /host="Streptococcus pyogenes ERR111909" /db_xref="taxon:2558713" gene complement(1..1164) /locus_tag="JavanS462_0001" CDS complement(1..1164) /locus_tag="JavanS462_0001" /codon_start=1 /transl_table=11 /product="integrase/recombinase" /protein_id="QBX10605.1" /translation="MNIKEYKKKNGTIVYRTSVYLGVDQVTGKKARTTITASTKKGVK IKARDALNNFAMNGYTVKEKPTVTTYKELTALWWESYKNTIKPNSRQSMEGIVRLHIL PAFGDCKLSRLTTPVIQQQVNKWANNANKGIKGAYANYSFLNNINRRILQYGVTMQVI EHNPARDVIIPRKQNNKEHKVKFFSNQELKQFLNYLDDLDLSSYENFFDYVLYKTLLA TGCRIGEVLALEWSDIDLEKGTIKVSKTLNRYQETNTPKSKAGLRDIEIDRATVLLLK QYKNRQQVLSWDLGRSETIVFTPFTTKYAYACLLRKRLQKHFKAAGVPDISFHGFRHT HATIMLYAGIEAKDLQYRLGHSNISMTLNTYVHATKEGAKKAVSIFETAISNL" gene 1388..1585 /locus_tag="JavanS462_0002" CDS 1388..1585 /locus_tag="JavanS462_0002" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10606.1" /translation="MLGGAFMIFSILKEYKSFKNEVAEHRVEQCKKTEKLHRNFLKVK RRNEEFRKEFDERFKRYSRGL" gene complement(1794..2885) /locus_tag="JavanS462_0003" CDS complement(1794..2885) /locus_tag="JavanS462_0003" /note="FIG01117716: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10607.1" /translation="MNISKDTELQFNYLFEKLLEKLPSVNSNKDYWFVRAQRGLFFKS FLSGGYIAIGWNHITFDDLDNLDEDSVKRKIKEFDKNIEKPGSAYNQMMKFTYSINVG DIVIVPSEAPNDFLVGEVTSRPYTETEENIESASNVCPFNKRIKVHWLGTIANRDIDP QLYKLIYSGHTITDANAYKKFINRGLYDAYIDEDFMSVTFKVQQESNIDVFEYTTFLH TLTQMIKIIEKSTKPGDKKVILRTNVQSSGPVEFLGDPMTLAVLLTFVLVFAGGFAFK HHIKKNGAEIEVDLKGAKIKAKLNSDGDEAIKKAQANKINAEAIALLVEKGLSPELED ATAQLKIKSPEVATKIICDELLESPEKDE" gene complement(3231..3680) /locus_tag="JavanS462_0004" CDS complement(3231..3680) /locus_tag="JavanS462_0004" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10608.1" /translation="MNRLKELRTDQKKTQKDIAEFLNMSRRGYQKIENGESQIKTDKA QALADYFKVSVGYLLGYEDNPSNRPLGFDTPEEFEKVRKRIIENNKIHGGGASLKLAY GAGKLTDIFESKGVDGKERLLEHYSKLTDKDKRVIEYLAYSLSQKDI" gene 3835..4020 /locus_tag="JavanS462_0005" CDS 3835..4020 /locus_tag="JavanS462_0005" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10609.1" /translation="MLITSTQAKAIRRKQADKQLTSKSASAKIGISEVTYRKVRNGGE VKNGIYQAVMEWLAEDY" gene 4246..4449 /locus_tag="JavanS462_0006" CDS 4246..4449 /locus_tag="JavanS462_0006" /note="FIG01115767: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10610.1" /translation="MTDRANDILTDYEGICGQVSDVLKVLDLAAQEYSKETTSAIINT SCHALNYLIADHTKITHKYREKA" gene 4452..4643 /locus_tag="JavanS462_0007" CDS 4452..4643 /locus_tag="JavanS462_0007" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10611.1" /translation="MQELNLTPTQTLVLFIVLGLVGLLLSLSKPLIEIDLPEDTQVPK PRQNTNYGAYIQSQNHYYN" gene 4654..4920 /locus_tag="JavanS462_0008" CDS 4654..4920 /locus_tag="JavanS462_0008" /note="FIG01114073: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10612.1" /translation="MQLLSREAELELLEKVDKYLEKRLQLELENNDGWDLISRADLLG KLKVSSTTLGNWEKVGLRPYQSPFENSKKIYYRKSDVYNFLAVE" gene 4969..5787 /locus_tag="JavanS462_0009" CDS 4969..5787 /locus_tag="JavanS462_0009" /codon_start=1 /transl_table=11 /product="putative DNA replication protein" /protein_id="QBX10613.1" /translation="MGNRRMISKTVTQTQRFLRLPLETQALYFHLIQSADDDGVIEAF PILRMINATEDSLGLLVVKNFIRPLNDEMVYFIIDFHEQNKVRADRKVNSVYIDLLKE VVPNIELINPRQRVDRKNKCREGAGLTRDNLGTDKGQQNISQYKSSQYNLIKSRSRQK DEDEKNKNPIFEKLKEAFGEMSVNGTMVTEVEDLLELHGQALLLYALEVTILNAGKSI RYTRTILSNWQGQGLRTVEQIKQHEEKRQQQKHPQTQPELTNFEDWEPTAENPF" gene 5803..6663 /locus_tag="JavanS462_0010" CDS 5803..6663 /locus_tag="JavanS462_0010" /note="Helicase loader DnaI" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="QBX10614.1" /translation="MLTQVEIVRSTKELDEICPIHKVHILQLDKVVKIAGENEPRKPS PFCPECVKEQRKKKEQEELEKLLNVGIYQKTYNVLMRDSTIPKELKEATFNNFKTETP EEKQLLAFAKNQVKKYLEGMRGNTLFTGSTGIGKSHLSVAMAKALNESYKAKGTPKSV LFVNLTEIIKQIKEGWNYGKGARLTEFEAVERLKSVDFLILDDLGAKNVTVSSKSDWE QDLLFDVLNGRENTIINTNLNATELKTVYNERNYSRILKGLEGNSFKSFTIKDKRYSI NNLKGKATQN" gene 6743..6916 /locus_tag="JavanS462_0011" CDS 6743..6916 /locus_tag="JavanS462_0011" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10615.1" /translation="MKLKLHTQGGNTITIQGDSAFYDELVKYLLSGRQPNWVTCPSAV INLSDIIAITKEK" gene 6918..7184 /locus_tag="JavanS462_0012" CDS 6918..7184 /locus_tag="JavanS462_0012" /note="FIG01115339: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10616.1" /translation="MRTFSDTPKQFMFTYQCKDYDTARVTSTAILGYITGTYEQNLAE ATLNGDGYLEVTYFEDKSINFNLKRICDSFKDYCNQPEDMEGEK" gene 7191..7349 /locus_tag="JavanS462_0013" CDS 7191..7349 /locus_tag="JavanS462_0013" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10617.1" /translation="MQDRTIKELVKVGWIFFQKDGKIESLERLEYGEVTFKFKEGRIY QVAKTETF" gene 7450..8052 /locus_tag="JavanS462_0014" CDS 7450..8052 /locus_tag="JavanS462_0014" /note="Prophage ps3 protein 07" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10618.1" /translation="MKKTVDIEKQFNALMLKNQEAIEEAKKEQEVWAKKIEDANQAAT EAQNAVDLVAYDKAKSDLFVATNSKELYEKRLDKLVNEPLVSYDDYFKFKKELQDIED SNQLSINQEAFQYIKKLQALAEKSRASIETTNSLLHQLQYGLGKNKDQYKRTKTGAVI SFNDLEYKYNTPNVFSFYHHTMEGSALVNAMKQEENENEY" gene 8042..8371 /locus_tag="JavanS462_0015" CDS 8042..8371 /locus_tag="JavanS462_0015" /note="FIG01116151: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10619.1" /translation="MSIKNDWYGELQDRAEKDHQQRVDQDKQMLKVITDKKEERAEQI QRVLDAGAEEYLRRKKHQDTEMVNKIRERSEKQLNNDLGKLGIKTKEQIEEENAFRDF ARKLTNK" gene 8631..8915 /locus_tag="JavanS462_0016" CDS 8631..8915 /locus_tag="JavanS462_0016" /note="FIG01120176: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10620.1" /translation="MKQKRKLNNSKKRTKQLPFANTNLKKRHDIEYIDPYKKKMDRAL KKKDWETYYRLYQQQVLDNEKEWGFTGIHIVNGIEVHDDDFVESVLKTLE" gene 9021..9431 /locus_tag="JavanS462_0017" CDS 9021..9431 /locus_tag="JavanS462_0017" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10621.1" /translation="MLPEQIKSKLERIKHLDIEIKGLYYELQYIDDSLFQKSTLTPSK VKTSQENGTEKHLLNQLELKDKITESIHKLIQERLEITELINLLDAPLERTVLRMYYV NHLEVWKIAEQLSKGEATVYRKLREAIKHLSEVV" gene 9509..9706 /locus_tag="JavanS462_0018" CDS 9509..9706 /locus_tag="JavanS462_0018" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10622.1" /translation="MNLRQYLGKDIKVTFVDGQVLEGHCNTFTGKLDTKDELYDEITI KTDKNPYIGFNESEIKSIEII" gene 9797..9970 /locus_tag="JavanS462_0019" CDS 9797..9970 /locus_tag="JavanS462_0019" /note="FIG01116340: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10623.1" /translation="MIATLQHERQIAVIKARYVDDLSWDEILDKLGYSRNTVFKLHRE ALEVLDEQEERYS" gene 9945..10313 /locus_tag="JavanS462_0020" CDS 9945..10313 /locus_tag="JavanS462_0020" /note="encoded transcriptional regulator, ArpU family" /codon_start=1 /transl_table=11 /product="ArpU family encoded transcriptional regulator" /protein_id="QBX10624.1" /translation="MNKKNAIRKIKEFHRWQRIANSLDLSYNERYQFDIDYHYSERRE LEISRECALEELNAIKYAINQLPKIEYRQILIECYLISEKLSNQEIMTKLNRSESWYY ETKKRALLEFVKKYRDGCLL" gene 10357..10500 /locus_tag="JavanS462_0021" CDS 10357..10500 /locus_tag="JavanS462_0021" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10625.1" /translation="MDFSDFLNKKQKEWDEFYPIPDFSAMSDEELLYQPMSEALLSEK FAK" gene 10818..11327 /locus_tag="JavanS462_0022" CDS 10818..11327 /locus_tag="JavanS462_0022" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10626.1" /translation="MDTVVFNDKDFLVNFLYKLLDNPTQIKVQKTLYLLFAFYGATYG NLENNQDDQNEFSEQSYPKALFMANFEAWRYGPVETDVYANEKLGLYSDEKLDNEIID DFFNTSEFKNVKDFIENIVEQTNQIDDFSLVDRTHQDNVWLDAYKEGENHIPMDNEEI VQEYIKRYV" gene 11320..11958 /locus_tag="JavanS462_0023" CDS 11320..11958 /locus_tag="JavanS462_0023" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="QBX10627.1" /translation="MSKSSDFFNSLSVGPKKGPITISTRNLVFDTIETSKIEAPQVNA TVEFSDLATNCYNIPEIAFSNCYPSSIEEGATHAHVVTAFQMLNNNVNIIKDGIKQIH HYGRNKERIEIILKTYLNNDFNTFYGCYYKSDIITSSFLSNRGKFRVISLYIVEPKKD KRQRHSKHKLIVLFFDPYHLFILLKTMEHQYIVKYLIILPIIAIFYINKDTP" ORIGIN 1 ttataaattg ctaatagctg tctcaaaaat cgagacggct tttttagcgc cttcttttgt 61 tgcatggaca taagtattca atgtcattga gatattagag tggcccaacc tatattgcaa 121 gtctttagcc tctatcccag cgtaaagcat aattgtagcg tgggtgtggc ggaagccatg 181 gaaactaata tcaggcacgc cagcagcttt aaaatgcttt tgaagccttt ttctaagcaa 241 acaagcgtag gcgtattttg tggtaaacgg agtaaaaaca atcgtctcag accgtcctag 301 atcccaagat aaaacttgct gacggttttt atattgttta agaagtaaga cggtagctct 361 atcaatctca atgtctctta atcctgcttt tgatttaggg gtgtttgtct cctgatatct 421 attcagagtt ttggaaacct tgatagttcc tttttctaaa tcaatatcag accattcaag 481 agctagaact tctccaatcc gacaaccagt agcgagcaag gtcttgtaaa gaacgtaatc 541 aaagaagttt tcatagctag ataaatctaa gtcatctaaa tagttcaaga attgctttag 601 ttcttgattg ctgaagaact tcaccttatg ttctttgtta ttttgttttc gaggaatgat 661 gacatcacga gctggattat gttcaataac ttgcatagta acgccatatt gtaggatacg 721 gcgattgata ttatttagaa agctgtagtt agcatatgcg cctttaatgc ccttattagc 781 gttgttagcc cacttattaa cttgttgttg aataacaggg gtagttagcc tagatagctt 841 gcaatcccca aatgcgggca aaatatgaag tcttacaatc ccttccatag attgtcgaga 901 gtttggtttg attgtattct tgtaactctc ccaccaaagg gctgtcaact ctttataagt 961 ggttactgtc ggcttctctt tgacggtata gccattcata gcaaagttat ttagagcatc 1021 acgagctttt attttaaccc cttttttagt tgaagctgta atagtcgtgc gagccttctt 1081 acctgttacc tggtcaacac caagatagac actagtgcgg taaacgattg tgccgttctt 1141 ctttttgtat tcttttatgt tcatgataat acctttctaa catcagtaag caagtatggg 1201 atttagttag gtatttaggt tttatcatgg ggaataggta agtaatttcc aaatcgttga 1261 acttgaacgt ttaacgattt aggcacagta gctttttaat tagtttttaa aggtaagcgt 1321 aggctttttg gatttctgat aataaaaagc ggcagattgt aaaatatgtt ataattttaa 1381 aaaagttatg ctgggtggtg cttttatgat ttttagcatt ttaaaagaat ataaatcttt 1441 taaaaatgaa gttgctgaac atcgtgttga gcaatgtaag aaaacagaaa aactgcatag 1501 gaacttttta aaagttaaga gaagaaacga agaatttaga aaagaatttg atgaaagatt 1561 caaacgttac tcaagagggt tgtaatacct tgcctctgtt ttaatagctg gatagctgga 1621 aagggtgaaa actatgaaac ttaagatata ctcacatctt gctgttttac ttgaattatc 1681 agctttttta tttatcacta tttacctagt cttactattt ttttcatcat tgaataatac 1741 tttgttatta tattttttgt ccttatttgt gagccttctg ttagcagaaa ttattattca 1801 tctttttctg gagattcgag tagttcatcg caaatgattt ttgtagctac ttctggggat 1861 tttattttta attgcgcagt agcgtcctct aattctggag ataaaccttt ctcaaccaat 1921 aatgcaattg cctcggcgtt tattttgttc gcttgggctt tttttattgc ttcgtcacca 1981 tcactgttta attttgcttt tatcttggct ccctttaaat caacctcaat ttctgctcca 2041 ttcttcttga tatgatgttt aaaagcaaat cccccagcaa atacaagaac aaatgttagt 2101 aagacagcta atgtcattgg atccccaaga aattcaacag gaccactaga ttggacattt 2161 gttctgagta taactttttt atctccaggc ttcgtagatt tctctatgat ttttatcatt 2221 tgtgtcaatg tatgtaaaaa agtagtgtat tcaaacacgt caatattgct ctcttgttgt 2281 actttaaatg tgacactcat aaaatcttcg tcaatataag catcataaag tccacgattg 2341 atgaatttct tatatgcatt ggcatccgtg attgtatgcc cagagtagat taacttatat 2401 agttgagggt caatgtctct atttgcaatt gttcctagcc aatgaacttt aattcgttta 2461 ttaaatggac aaacatttga tgccgattcg atattttctt ctgtttcagt atatggacga 2521 ctagtaacct caccaacaag gaaatcatta ggtgcttcag atggaacaat gactatatca 2581 ccaacattga tactataagt aaatttcatc atctgattat aagcagaacc aggtttttca 2641 atattcttat caaactcttt gattttcctt tttacagaat cttcgtccaa attatctaaa 2701 tcatcaaaag taatatgatt ccatcctatt gcaatgtacc ctccacttaa aaagctctta 2761 aaaaatagcc ctctctgtgc tctcacaaac caataatcct tgttactatt tacagatggt 2821 agcttttcaa gcaatttttc aaataaataa ttaaattgta attcagtatc tttagatata 2881 ttcattttta gtctctctca agtaaacttt ttgtctcatt taattcatta aatccttcct 2941 tgaccataac ttcaccattt gtggtttttt atcttttcaa ataattagca ataactatcg 3001 tgacttatcc atatataaac aacaagacag aatataaaga ttagtaagta cttcatggca 3061 attcctttct ttttagggtg actattacat taagacatgc catcagacat ttaagatact 3121 ggatacagta aagcacagtg ggaaacagtg atgagtgcta aacatagctc cgaaaatttc 3181 caattattta tgtttgaggg tgattcacta gaaaatacta gcaagtacaa ttatatatct 3241 ttttgtgata gtgaataagc gagatactca attactcttt tatctttatc agtcaatttt 3301 gaatagtgtt ctaagagacg ttcttttcca tctacgcctt tactttcaaa aatatcagtt 3361 aactttccag caccatacgc aagtttaaga cttgctccac cgccatgtat tttgttattt 3421 tcaataattc ttttgcggac tttttcaaat tcttcggggg tgtcgaaacc taatggtctg 3481 tttgacggat tatcttcata tcccaacaga tatcccacgg acactttgaa ataatcagct 3541 agggcttggg ctttgtcggt ttttatttgg ctttcaccat tttctatttt ttgataacct 3601 cggcgactca tattcaaaaa ctcagcaata tctttttgtg tctttttttg atcagttctt 3661 aattctttca atctattcat aatttattac ctcgacttga ttatatcata aaaggaaata 3721 taagctaact tttttttcac tttttgtact taatctcttg acaaggaact ttaagttagc 3781 taaaatacat ttataaagct aacagaaagt tagctaagaa aggagttaaa attattgctt 3841 attacctcaa cacaagcaaa agctatccga agaaaacaag ctgataaaca actaacttca 3901 aagtcagcaa gcgcaaagat tgggatttca gaagtaactt atcgcaaagt tcgtaatggt 3961 ggagaagtca aaaatggtat ttatcaagct gtcatggaat ggctagcaga agattattaa 4021 gacaacaaaa aagccttagc agtcggcaaa ctcacaaggc ttttaactca aacaactaaa 4081 accacaaaaa gcaagtatgg gatttagtta ggtatttatt taattgtacc acaattagtg 4141 gtatgtgacc atacgtaggg agctacccct taaaactaac atgaatctag tatagtaaaa 4201 aaccgaaaat agaaaatatt acacagaaaa tataaaggtg aggaaatgac tgatcgagca 4261 aatgatattt taacagatta tgagggtata tgtggccagg tttcagatgt tctaaaagtc 4321 ttggatttgg ctgctcaaga atatagcaag gaaacaacta gcgcaatcat aaacactagt 4381 tgtcatgctt tgaattacct tattgctgac cataccaaga taacacataa ataccgggag 4441 aaggcgtaac tatgcaagaa ctaaatttaa caccaacaca gacacttgtt ctattcattg 4501 ttttagggct tgtagggctt cttcttagcc tttctaagcc attaatagag attgacttac 4561 cagaagatac ccaagtacct aaaccacgtc agaacaccaa ctacggggct tatattcaat 4621 cacagaacca ttattacaat taggagggaa cagatgcaat tattatcgcg agaagcagaa 4681 ttagaactgc tagaaaaagt agataagtat cttgagaagc gtttgcaact tgaactagaa 4741 aacaatgatg gttgggactt gatttctaga gctgacttat tgggaaaact aaaagttagt 4801 agcacaactc taggtaattg ggaaaaggtc ggcttgagac cctatcaatc accgtttgag 4861 aatagcaaaa agatctatta tagaaaatcg gacgtgtata actttttggc agtggaatga 4921 ggcgaatctc gttattaaca accactataa ttacggaaag agagaacaat gggaaataga 4981 cgtatgatta gcaaaacagt tacgcagaca caaagatttt taaggttacc acttgagaca 5041 caagctctat attttcactt aattcaaagt gctgatgatg atggtgtcat tgaggcgttt 5101 ccgattttaa gaatgataaa tgcgactgaa gatagtctag gattattagt agttaaaaat 5161 tttataagac cactcaatga tgaaatggta tattttatta ttgattttca tgaacagaat 5221 aaagttagag ctgataggaa agtgaattct gtatacattg atttattaaa ggaagtagtt 5281 ccaaatattg aacttataaa ccctagacaa cgtgtggata ggaaaaataa atgtcgtgaa 5341 ggtgcaggac taactcggga caaccttggg acagacaaag gacagcagaa tataagtcaa 5401 tataagtcaa gtcaatataa tctaattaaa tctaggtcaa gacaaaaaga cgaggacgaa 5461 aaaaataaga acccaatatt tgaaaaattg aaagaagctt ttggagaaat gtcagttaat 5521 ggaaccatgg taacagaggt tgaggatttg ttagaacttc atggacaagc gttgttatta 5581 tatgctttgg aggtaactat cctgaatgct ggtaaatcta ttaggtacac ccgtacaatt 5641 ctttctaatt ggcaaggtca aggtctaaga actgtagaac agattaaaca gcacgaggaa 5701 aaacgtcagc aacaaaaaca tcctcaaact caaccagaac ttacaaattt tgaagattgg 5761 gagccaacgg cagaaaatcc attttagaaa aggagagaga atatgctaac acaggtagaa 5821 attgtaagaa gcacaaagga attagatgaa atttgcccta ttcacaaagt tcatatttta 5881 caacttgata aagttgtaaa aattgcagga gagaatgaac cacgaaaacc ttcaccattt 5941 tgtcctgaat gcgtaaaaga acagaggaaa aagaaagaac aagaggaatt agagaaactc 6001 ttgaacgttg gaatctatca gaaaacctat aatgtgctta tgagagatag cacgattcct 6061 aaagagctta aggaggcaac ctttaataat tttaaaactg agacgccaga ggaaaaacaa 6121 ctactagcct ttgctaaaaa tcaagtaaag aaatatctgg agggaatgag aggaaatacc 6181 ctttttacag gatctacagg cataggaaag agtcatctaa gtgttgctat ggcaaaagca 6241 ttaaacgaga gttataaggc taaaggaaca cctaagagtg tgctttttgt aaacctaact 6301 gaaatcatta aacagattaa ggaaggatgg aattatggta aaggagcaag acttacagaa 6361 tttgaagcag tagaacgact gaaaagtgtt gactttctta tcctagatga tttaggggct 6421 aagaatgtaa cagtaagttc aaagagtgac tgggagcaag acctattgtt tgacgtactc 6481 aatggccgtg agaatacgat tattaataca aatctaaatg ccacagagtt aaagacggtt 6541 tacaatgagc gtaattatag tcgtatccta aagggtttag aaggtaattc tttcaaatcg 6601 ttcactatca aagacaaacg ttactcaatc aataatctaa agggaaaggc tactcaaaat 6661 tgattagaaa gacattcaaa ggtactaata tgaagacatg gattcaagaa cgggactatt 6721 ggtcttgcac aggtaactgg agatgaaact taaactacac acacaaggtg gcaacaccat 6781 caccatacaa ggagacagcg ccttttatga tgagttggtc aaataccttc tttctggccg 6841 acaaccaaac tgggtaacat gtccttctgc cgtcatcaat ttatcagaca ttatagcaat 6901 cacaaaggag aaataatatg agaacatttt cagacacacc aaaacaattt atgtttactt 6961 accaatgcaa ggactacgat acggccagag taacaagtac agctatttta ggttatatca 7021 cagggactta tgagcaaaat ctagcagaag ccactctgaa cggagatggt tacttagaag 7081 tgacctattt cgaggacaag tctattaatt tcaatctaaa acgcatctgc gacagtttca 7141 aagattattg taatcaacct gaagatatgg aaggtgaaaa ataaggaagc atgcaagata 7201 gaacaataaa agaattggtt aaggtcggtt ggatattttt ccaaaaagat ggtaaaatag 7261 aatcactgga acggctggaa tatggtgaag tcacctttaa atttaaagag ggtaggattt 7321 accaggtagc taaaacagaa acattttaat aattaagtct aaaagagaag aactcacgga 7381 caaaaccaag ctattaagat tagctagttt tgttggtggg ttcttttaat ttagcagaaa 7441 ggaaacaaaa tgaaaaagac agtagatatt gaaaaacaat ttaatgcttt gatgcttaaa 7501 aatcaagaag ccattgaaga ggcaaagaaa gaacaagagg tttgggctaa aaaaatagaa 7561 gatgccaatc aggcggctac agaagctcaa aatgcagtgg atttagtagc ttatgacaag 7621 gctaaaagtg atttgtttgt tgccacaaac agcaaagagc tatatgaaaa gcgcttagat 7681 aaattggtga atgaacctct tgtttcctat gatgactatt ttaaattcaa aaaagaatta 7741 caagatattg aagatagcaa ccaactaagt attaatcaag aagcgtttca atacattaag 7801 aaacttcaag cattagcgga aaaatctcga gcaagtatag aaacaacgaa tagcctgtta 7861 catcagttac agtatgggtt aggaaagaat aaggaccagt ataaacggac taagacaggt 7921 gctgttataa gtttcaatga tctagagtat aaatataata cccctaatgt atttagtttt 7981 tatcatcata ccatggaggg cagtgcttta gtgaatgcta tgaaacagga ggaaaatgaa 8041 aatgagtatt aaaaatgatt ggtacggaga gcttcaagac agagctgaga aagaccacca 8101 acagcgagtg gatcaagata aacaaatgtt aaaggttata actgataaga aagaagaacg 8161 agcagagcag attcaacgtg tgttagatgc tggagctgaa gaatatttgc gaaggaaaaa 8221 gcaccaagat actgagatgg tcaataagat tcgtgaacgt agtgaaaaac aattgaacaa 8281 tgatcttggc aagttaggaa ttaaaactaa agaacaaatt gaagaagaaa atgcttttag 8341 ggattttgca cgtaaactaa caaacaaata gttttaaaaa tgtattaatt cttttcgcgt 8401 taatgaaatg gggggggtat ggccctcccc ggtcggccgg ccgagcttca cgccgtcact 8461 gtacattttt tctcacgtta gcaaatggga ttagagagga ttattttttg aaggtattta 8521 gtaagctgtg taacgtctgt ggcggaggtt ttgagtcctc ttcgaatgtc tcaaaatact 8581 gtagtgacaa gtgtcgaagg caatctataa gaactagaca aaatcattat atgaaacaaa 8641 aaaggaagtt gaataactca aaaaaacgaa ccaaacaact tccatttgct aacacaaatt 8701 taaaaaaaag acatgatata gaatatattg atccctataa gaaaaaaatg gatagagctt 8761 taaaaaagaa agactgggaa acctattata ggctatatca gcaacaggtt ttagataatg 8821 aaaaagaatg gggatttact ggaattcata tcgttaacgg tattgaagtt catgatgacg 8881 attttgttga aagtgtccta aaaacgttag aataacaaaa aaatcctaca aaactttgta 8941 ggaaaaggac tcttgggtac aaggaagacc cttgaataat atcagatttg attatagtat 9001 atcataattg gagggttaga atgttacctg agcaaataaa atctaaattg gaacgcatca 9061 aacatttaga cattgagatt aaaggtcttt attacgaact tcagtatata gatgatagtc 9121 tttttcagaa atcaacacta actccgtcaa aagtaaaaac aagtcaagaa aacggcacag 9181 agaaacatct acttaatcaa ttagaactca aagataaaat caccgaatct atccataaat 9241 tgatccagga aagattagaa atcactgaat taattaattt gttagacgct cctcttgaaa 9301 gaacagtttt aagaatgtat tatgttaatc acttagaagt ttggaaaata gctgaacaac 9361 tcagtaaagg agaggccaca gtctacagga agcttcgtga ggctataaaa cacttatctg 9421 aggtagttta ataaaagtga gatttgaact ataggaacta atattataaa agtagaaccc 9481 atatagtacc taagaaagga gaccaataat gaatttacgc cagtatttag gaaaagacat 9541 caaagttact tttgttgatg gtcaagtcct tgaaggtcat tgtaatacat tcacaggaaa 9601 actcgatacg aaagatgagt tgtatgatga aatcacaata aaaactgata agaacccata 9661 tattggtttt aatgaatcag aaatcaaatc aattgaaatt atttaataag cacttgacta 9721 tcatagctac ttacttttta ttatgtcccc tcccaaagga gtatattgta gctaggaacg 9781 tgacaagaga ctggccatga ttgccacatt gcaacatgaa agacagatag ctgttattaa 9841 ggctagatac gtggatgact tatcatggga cgagatactc gataaactag gttactcaag 9901 aaacactgtg ttcaaactac atagagaagc tttagaggtg ttagatgaac aagaagaacg 9961 ctattcgtaa aataaaagag ttccatagat ggcaacgtat cgctaatagc cttgatttaa 10021 gctataacga gcgttaccag tttgatatag attaccatta ctctgaacgt agagagcttg 10081 aaataagccg agaatgcgcc ctagaggagc taaacgctat caagtatgcc atcaatcaat 10141 tacctaagat agagtataga caaatactga ttgagtgcta cttgattagt gaaaagttat 10201 ctaatcaaga gattatgacg aaacttaatc gctctgaaag ttggtactac gagactaaga 10261 aaagagcttt gcttgagttt gtgaagaaat acagggatgg ttgtttgtta tgatataatt 10321 agtggcaaaa tatgtgatat aaggaaagag taagcgatgg atttttctga ttttttgaat 10381 aaaaaacaaa aagagtggga tgaattctat ccaatccctg actttagtgc aatgagtgat 10441 gaagaattgc tttatcagcc gatgagcgaa gctttgctat ctgagaagtt cgctaaataa 10501 ctatctaaag agattgaaaa gcgtaaatta cttccgaata gaaaccaata tgattatgaa 10561 gcagagaaac gatggtccgc aggagagcat ttctctgctt ttttcttact taaaaatcgt 10621 aaaaactgca ataaccccac ttaaaagtat ggtaaaatag aaaactcgat aaaaattatt 10681 gacaaaatgt actaaataag atatattttg attgtttata taacataagt aatataatct 10741 tatagatttg gaattaacac aagtgacagt tgtgatactt gtgttttttt atttcaaaag 10801 tatagaggta tttaaaaatg gacactgtag tatttaatga taaagatttt ttagttaact 10861 tcttatacaa attattagat aatccaactc aaattaaagt tcaaaaaact ttatatcttt 10921 tatttgcttt ttatggcgca acatatggaa atctagaaaa taatcaagat gaccagaacg 10981 aattttcaga acaaagctat cctaaagcac tatttatggc aaactttgaa gcttggagat 11041 acggaccagt tgaaactgat gtttatgcaa atgaaaaatt agggttatac tctgatgaaa 11101 aactagataa tgaaataatt gacgattttt ttaacacatc agagtttaaa aatgtaaaag 11161 actttatcga aaatattgtg gaacaaacaa accaaattga tgattttagc ttagttgata 11221 gaactcatca agataatgtt tggttagacg cttataaaga gggtgagaat catatcccta 11281 tggataatga ggaaattgtt caggagtata tcaaaagata tgtctaaaag ttccgatttt 11341 tttaatagtt tatcagttgg acctaagaag ggtccaatta ctatttccac aagaaattta 11401 gtgtttgata caattgagac aagtaaaata gaagcaccac aagttaatgc aacggtagaa 11461 ttttctgacc tagcaactaa ctgttacaat attcctgaaa tcgcattttc aaactgctac 11521 ccttcatcaa ttgaagaagg agctactcat gctcatgtag taactgcatt ccaaatgtta 11581 aataataatg ttaatattat aaaagatggc attaaacaaa ttcatcatta tggaagaaac 11641 aaagagcgga ttgaaataat tttaaaaact tatcttaata atgattttaa tactttctat 11701 ggttgctact ataaaagcga tataattact agttcatttt tatcaaatag aggaaaattt 11761 agagtgattt ctttgtatat tgtagagcct aagaaagata aacgtcaaag acactcaaaa 11821 cataagttaa tagttctctt ttttgatcca tatcatttat ttatccttct aaagactatg 11881 gaacatcaat atatagtgaa gtatctaatt atacttccaa tcattgcaat tttttatata 11941 aataaagaca ccccttaa //