locus-tag	class	description
T303_00010	COG0706	membrane insertase activity
T303_00075	COG0756	dUTP diphosphatase activity
T303_00105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
T303_00110	COG0457	Tetratricopeptide repeat
T303_00110	COG0705	Rhomboid family
T303_00115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
T303_00130	COG0647	UMP catabolic process
T303_00140	COG2226	methyltransferase
T303_00165	COG0425	Belongs to the sulfur carrier protein TusA family
T303_00170	COG2391	methyltransferase activity
T303_00175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T303_00180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
T303_00190	COG1363	Peptidase, m42
T303_00195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
T303_00200	COG1266	CAAX protease self-immunity
T303_00255	COG1459	type II secretion system
T303_00260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
T303_00295	COG0440	acetolactate synthase activity
T303_00300	COG0028	Belongs to the TPP enzyme family
T303_00310	COG1461	Dihydroxyacetone kinase
T303_00320	COG0534	Mate efflux family protein
T303_00350	COG3590	peptidase
T303_00355	COG0366	Alpha amylase catalytic
T303_00360	COG0366	Alpha amylase catalytic
T303_00365	COG0366	Alpha amylase catalytic
T303_00370	COG0366	Alpha amylase catalytic
T303_00380	COG1609	Transcriptional regulator
T303_00385	COG2188	Transcriptional regulator
T303_00390	COG4475	Protein of unknown function (DUF436)
T303_00425	COG2217	Heavy metal translocating P-type atpase
T303_00455	COG3328	transposase activity
T303_00465	COG0191	fructose-bisphosphate aldolase activity
T303_00510	COG0257	Belongs to the bacterial ribosomal protein bL36 family
T303_00525	COG0201	protein transport
T303_00670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
T303_00685	COG1132	(ABC) transporter
T303_00690	COG1396	sequence-specific DNA binding
T303_00695	COG1396	sequence-specific DNA binding
T303_00710	COG1132	(ABC) transporter
T303_00750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
T303_00795	COG0602	queuosine metabolic process
T303_00805	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
T303_00830	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
T303_00865	COG2261	transglycosylase associated protein
T303_00885	COG3237	CsbD-like
T303_00915	COG1511	domain protein
T303_00915	COG1511	domain protein
T303_00925	COG3759	membrane
T303_00945	COG0305	Participates in initiation and elongation during chromosome replication
T303_00965	COG0494	nUDIX hydrolase
T303_00980	COG0741	lytic transglycosylase activity
T303_00985	COG1388	LysM domain
T303_00985	COG3584	3D domain protein
T303_00990	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
T303_01005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
T303_01015	COG0612	Peptidase, M16
T303_01045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
T303_01050	COG0488	(ABC) transporter
T303_01085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
T303_01090	COG1475	DNA binding
T303_01100	COG0592	DNA-directed DNA polymerase activity
T303_01110	COG0012	GTP binding
T303_01120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
T303_01125	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
T303_01155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
T303_01175	COG2801	Transposase and inactivated derivatives
T303_01295	COG3942	CHAP domain
T303_01300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
T303_01310	COG0436	Aminotransferase
T303_01325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
T303_01335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
T303_01350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
T303_01375	COG1388	LysM domain
T303_01375	COG3942	CHAP domain
T303_01380	COG0151	Belongs to the GarS family
T303_01405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
T303_01425	COG4550	Control of competence regulator ComK, YlbF/YmcA
T303_01465	COG2818	Glycosylase
T303_01480	COG1393	Belongs to the ArsC family
T303_01570	COG2309	aminopeptidase activity
T303_01595	COG2801	Transposase and inactivated derivatives
T303_01635	COG4463	regulation of RNA biosynthetic process
T303_01640	COG0542	response to heat
T303_01650	COG1686	Belongs to the peptidase S11 family
T303_01665	COG1045	serine acetyltransferase
T303_01680	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
T303_01700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
T303_01730	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
T303_01800	COG1705	Flagellar rod assembly protein muramidase FlgJ
T303_01800	COG3942	CHAP domain
T303_01815	COG3830	Belongs to the UPF0237 family
T303_01825	COG0588	phosphoglycerate mutase activity
T303_01830	COG1876	peptidase activity
T303_01865	COG0351	phosphomethylpyrimidine kinase
T303_01870	COG4720	Psort location CytoplasmicMembrane, score
T303_01910	COG1473	amidohydrolase
T303_01930	COG0668	transmembrane transport
T303_01945	COG0504	CTP synthase activity
T303_01955	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
T303_01965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
T303_01970	COG0737	Belongs to the 5'-nucleotidase family
T303_02005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
T303_02050	COG1126	abc transporter atp-binding protein
T303_02055	COG0765	amino acid transport
T303_02070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
T303_02080	COG0719	Fe-S assembly protein
T303_02085	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
T303_02095	COG0719	Fe-S assembly protein
T303_02105	COG4166	transmembrane transport
T303_02110	COG0601	transmembrane transport
T303_02130	COG0444	Belongs to the ABC transporter superfamily
T303_02155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
T303_02170	COG1121	(ABC) transporter
T303_02175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
T303_02200	COG0217	transcriptional regulatory protein
T303_02215	COG4589	Belongs to the CDS family
T303_02230	COG4120	Belongs to the binding-protein-dependent transport system permease family
T303_02235	COG1116	anion transmembrane transporter activity
T303_02235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
T303_02280	COG0564	pseudouridine synthase activity
T303_02285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
T303_02310	COG1349	DNA-binding transcription factor activity
T303_02330	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
T303_02345	COG3579	cysteine-type endopeptidase activity
T303_02350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
T303_02375	COG0116	Belongs to the methyltransferase superfamily
T303_02385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
T303_02405	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
T303_02435	COG1254	Belongs to the acylphosphatase family
T303_02440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
T303_02475	COG3763	UPF0154 protein
T303_02485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
T303_02505	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
T303_02510	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
T303_02515	COG1187	pseudouridine synthase activity
T303_02525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
T303_02530	COG0569	domain protein
T303_02540	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
T303_02545	COG0671	phosphoesterase, PA-phosphatase related
T303_02580	COG0831	urea catabolic process
T303_02585	COG0832	Belongs to the urease beta subunit family
T303_02595	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
T303_02605	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
T303_02610	COG0829	nickel cation binding
T303_02615	COG0310	cobalt ion transport
T303_02625	COG1122	ATPase activity
T303_02630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T303_02635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
T303_02655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T303_02660	COG1464	Belongs to the NlpA lipoprotein family
T303_02670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
T303_02695	COG1122	ATPase activity
T303_02705	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
T303_02715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
T303_02730	COG0745	RESPONSE REGULATOR receiver
T303_02735	COG5002	protein histidine kinase activity
T303_02750	COG1484	DNA-dependent DNA replication
T303_02795	COG3716	PTS system mannose fructose sorbose family IID component
T303_02800	COG3715	PTS system
T303_02810	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
T303_02815	COG0561	phosphatase activity
T303_02820	COG2252	PERMEase
T303_02825	COG0802	atpase or kinase
T303_02830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
T303_02835	COG1316	TRANSCRIPTIONal
T303_02845	COG0195	Participates in both transcription termination and antitermination
T303_02850	COG2740	Nucleic-acid-binding protein implicated in transcription termination
T303_02885	COG2244	polysaccharide biosynthetic process
T303_02890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
T303_02895	COG0626	cystathionine gamma-synthase activity
T303_02900	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
T303_02925	COG4471	UPF0298 protein
T303_02935	COG0559	Belongs to the binding-protein-dependent transport system permease family
T303_02945	COG0411	ABC transporter
T303_02965	COG1739	Uncharacterized protein family UPF0029
T303_02970	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
T303_02975	COG1040	competence protein
T303_03055	COG0527	aspartate kinase activity
T303_03060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
T303_03065	COG1024	Enoyl-CoA hydratase
T303_03070	COG1846	Transcriptional regulator
T303_03090	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
T303_03095	COG1028	Short-chain dehydrogenase reductase Sdr
T303_03100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
T303_03115	COG0439	Biotin carboxylase
T303_03150	COG1349	DNA-binding transcription factor activity
T303_03155	COG1105	Belongs to the carbohydrate kinase PfkB family
T303_03165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
T303_03170	COG0285	dihydrofolate synthase activity
T303_03180	COG1104	cysteine desulfurase activity
T303_03240	COG0488	(ABC) transporter
T303_03260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
T303_03265	COG0242	peptide deformylase activity
T303_03325	COG1702	phosphate starvation-inducible protein PhoH
T303_03350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T303_03350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T303_03385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
T303_03415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
T303_03420	COG0436	Aminotransferase
T303_03435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
T303_03440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
T303_03445	COG0726	polysaccharide deacetylase
T303_03460	COG2962	Rard protein
T303_03500	COG0356	it plays a direct role in the translocation of protons across the membrane
T303_03510	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
T303_03535	COG0772	Belongs to the SEDS family
T303_03555	COG0470	DNA polymerase III
T303_03560	COG1774	PSP1 C-terminal conserved region
T303_03565	COG4467	Involved in initiation control of chromosome replication
T303_03575	COG0004	ammonium transporteR
T303_03580	COG0347	Belongs to the P(II) protein family
T303_03585	COG1388	LysM domain
T303_03585	COG1705	Flagellar rod assembly protein muramidase FlgJ
T303_03645	COG1113	amino acid transport
T303_03665	COG2801	Transposase and inactivated derivatives
T303_03695	COG0583	DNA-binding transcription factor activity
T303_03705	COG0564	pseudouridine synthase activity
T303_03725	COG0505	Belongs to the CarA family
T303_03770	COG0577	efflux transmembrane transporter activity
T303_03775	COG0577	efflux transmembrane transporter activity
T303_03800	COG0577	efflux transmembrane transporter activity
T303_03855	COG3279	Response regulator of the LytR AlgR family
T303_03865	COG1131	(ABC) transporter
T303_03900	COG1187	pseudouridine synthase activity
T303_03905	COG1473	amidohydrolase
T303_03910	COG0686	Belongs to the AlaDH PNT family
T303_03915	COG0686	Belongs to the AlaDH PNT family
T303_03920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
T303_03995	COG0438	transferase activity, transferring glycosyl groups
T303_04025	COG1272	protein, Hemolysin III
T303_04040	COG3425	synthase
T303_04050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
T303_04070	COG0833	amino acid
T303_04075	COG2040	homocysteine
T303_04095	COG0187	DNA topoisomerase II activity
T303_04105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
T303_04125	COG0539	negative regulation of cytoplasmic translation
T303_04160	COG0494	nUDIX hydrolase
T303_04165	COG0542	response to heat
T303_04170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
T303_04175	COG4703	Protein of unknown function (DUF1797)
T303_04185	COG1126	abc transporter atp-binding protein
T303_04235	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
T303_04240	COG0768	penicillin binding
T303_04260	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
T303_04265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
T303_04270	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
T303_04275	COG0237	dephospho-CoA kinase activity
T303_04295	COG0557	exoribonuclease II activity
T303_04310	COG1185	polyribonucleotide nucleotidyltransferase activity
T303_04315	COG0006	proline dipeptidase activity
T303_04320	COG1609	Transcriptional regulator
T303_04355	COG1368	sulfuric ester hydrolase activity
T303_04360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
T303_04385	COG0287	Prephenate dehydrogenase
T303_04410	COG0077	Prephenate dehydratase
T303_04415	COG1316	TRANSCRIPTIONal
T303_04470	COG2963	transposase activity
T303_04535	COG1518	maintenance of DNA repeat elements
T303_04540	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
T303_04550	COG3689	TIGRFAM TIGR03943 family protein
T303_04555	COG0701	Predicted permease
T303_04565	COG2183	response to ionizing radiation
T303_04630	COG4443	Transcriptional Coactivator p15 (PC4)
T303_04640	COG1914	H( )-stimulated, divalent metal cation uptake system
T303_04650	COG0494	nUDIX hydrolase
T303_04660	COG3328	transposase activity
T303_04670	COG1705	Flagellar rod assembly protein muramidase FlgJ
T303_04670	COG1388	LysM domain
T303_04690	COG0406	alpha-ribazole phosphatase activity
T303_04695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
T303_04740	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
T303_04795	COG1704	LemA family
T303_04825	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
T303_04835	COG0783	Belongs to the Dps family
T303_04840	COG0735	belongs to the Fur family
T303_04845	COG4483	Protein conserved in bacteria
T303_04850	COG1940	carbohydrate kinase activity
T303_04880	COG0849	cell division
T303_04890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
T303_04910	COG3599	regulation of cell shape
T303_04940	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
T303_04945	COG0625	glutathione transferase activity
T303_04955	COG1435	thymidine kinase activity
T303_04965	COG2890	protein-(glutamine-N5) methyltransferase activity
T303_04990	COG1132	(ABC) transporter
T303_04995	COG1132	(ABC) transporter
T303_05010	COG1696	Membrane protein involved in D-alanine export
T303_05020	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
T303_05040	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
T303_05045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
T303_05115	COG1396	sequence-specific DNA binding
T303_05120	COG0582	viral genome integration into host DNA
T303_05140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
T303_05145	COG4684	Psort location CytoplasmicMembrane, score
T303_05150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
T303_05180	COG2801	Transposase and inactivated derivatives
T303_05195	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
T303_05200	COG0038	chloride channel
T303_05215	COG2801	Transposase and inactivated derivatives
T303_05235	COG2813	Specifically methylates the guanine in position
T303_05250	COG0295	cytidine deaminase activity
T303_05255	COG1744	ABC transporter substrate-binding protein PnrA-like
T303_05280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
T303_05280	COG1199	ATP-dependent helicase activity
T303_05290	COG0436	Aminotransferase
T303_05310	COG0251	oxidation-reduction process
T303_05320	COG0720	synthase
T303_05350	COG1660	Displays ATPase and GTPase activities
T303_05375	COG1278	Cold shock
T303_05385	COG2801	Transposase and inactivated derivatives
T303_05395	COG3328	transposase activity
T303_05405	COG2217	Heavy metal translocating P-type atpase
T303_05410	COG3328	transposase activity
T303_05420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
T303_05425	COG0626	cystathionine gamma-synthase activity
T303_05435	COG3328	transposase activity
T303_05450	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
T303_05455	COG4975	Glucose uptake
T303_05475	COG3443	Belongs to the bacterial solute-binding protein 9 family
T303_05475	COG0803	Belongs to the bacterial solute-binding protein 9 family
T303_05495	COG1705	Flagellar rod assembly protein muramidase FlgJ
T303_05495	COG3942	CHAP domain
T303_05515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
T303_05520	COG2824	Alkylphosphonate utilization operon protein PhnA
T303_05525	COG0765	amino acid transport
T303_05530	COG1126	abc transporter atp-binding protein
T303_05555	COG1064	alcohol dehydrogenase
T303_05575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
T303_05575	COG0519	Catalyzes the synthesis of GMP from XMP
T303_05590	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
T303_05600	COG1827	regulation of RNA biosynthetic process
T303_05610	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
T303_05620	COG1940	carbohydrate kinase activity
T303_05625	COG0758	DNA mediated transformation
T303_05630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
T303_05685	COG1396	sequence-specific DNA binding
T303_05695	COG3328	transposase activity
T303_05705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
T303_05720	COG0028	Belongs to the TPP enzyme family
T303_05725	COG3527	Alpha-acetolactate decarboxylase
T303_05755	COG1230	cation diffusion facilitator family transporter
T303_05765	COG1063	alcohol dehydrogenase
T303_05805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
T303_05835	COG0047	phosphoribosylformylglycinamidine synthase activity
T303_05845	COG0167	dihydroorotate dehydrogenase activity
T303_05850	COG1518	maintenance of DNA repeat elements
T303_05850	COG1468	defense response to virus
T303_05855	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
T303_05875	COG1337	RAMP superfamily
T303_05880	COG1567	CRISPR-associated RAMP protein, Csm4 family
T303_05895	COG0284	orotidine-5'-phosphate decarboxylase activity
T303_05915	COG3104	oligopeptide transport
T303_05935	COG0737	Belongs to the 5'-nucleotidase family
T303_05945	COG1917	Cupin 2, conserved barrel domain protein
T303_05945	COG2207	Transcriptional regulator
T303_05960	COG1115	amino acid carrier protein
T303_06000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
T303_06005	COG0196	riboflavin kinase activity
T303_06010	COG1393	Belongs to the ArsC family
T303_06020	COG0483	inositol monophosphate 1-phosphatase activity
T303_06025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
T303_06025	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
T303_06030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
T303_06035	COG0573	inorganic phosphate transmembrane transporter activity
T303_06040	COG0581	inorganic phosphate transmembrane transporter activity
T303_06055	COG0704	Plays a role in the regulation of phosphate uptake
T303_06070	COG0095	Lipoate-protein ligase
T303_06080	COG0058	SHG alpha-glucan phosphorylase activity
T303_06085	COG1640	4-alpha-glucanotransferase
T303_06090	COG1609	Transcriptional regulator
T303_06100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
T303_06105	COG0805	protein transport
T303_06110	COG0672	)-iron permease
T303_06115	COG2837	iron assimilation
T303_06120	COG2822	iron ion transport
T303_06125	COG4607	ABC-type enterochelin transport system periplasmic component
T303_06130	COG4604	ABC transporter, ATP-binding protein
T303_06135	COG4605	iron ion homeostasis
T303_06140	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T303_06150	COG1523	belongs to the glycosyl hydrolase 13 family
T303_06160	COG1523	belongs to the glycosyl hydrolase 13 family
T303_06185	COG0508	dehydrogenase complex catalyzes the overall conversion of
T303_06190	COG0022	dehydrogenase e1 component
T303_06190	COG0508	dehydrogenase complex catalyzes the overall conversion of
T303_06195	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
T303_06220	COG1518	maintenance of DNA repeat elements
T303_06235	COG1857	crispr-associated protein
T303_06275	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
T303_06285	COG4667	esterase of the alpha-beta hydrolase superfamily
T303_06315	COG0628	permease
T303_06325	COG0561	phosphatase activity
T303_06336	COG0562	UDP-galactopyranose mutase
T303_06350	COG2244	polysaccharide biosynthetic process
T303_06355	COG1216	Glycosyl transferase, family 2
T303_06355	COG1442	glycosyl transferase family 8
T303_06360	COG0489	protein tyrosine kinase activity
T303_06370	COG1442	glycosyl transferase family 8
T303_06370	COG1216	Glycosyl transferase, family 2
T303_06420	COG1316	TRANSCRIPTIONal
T303_06445	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
T303_06455	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
T303_06460	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
T303_06480	COG1573	uracil-dna glycosylase
T303_06550	COG0681	Belongs to the peptidase S26 family
T303_06560	COG0628	permease
T303_06565	COG1051	belongs to the nudix hydrolase family
T303_06570	COG2177	Part of the ABC transporter FtsEX involved in
T303_06575	COG2884	Cell division ATP-binding protein ftsE
T303_06580	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
T303_06585	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
T303_06625	COG2348	transferase activity, transferring amino-acyl groups
T303_06635	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
T303_06640	COG5002	protein histidine kinase activity
T303_06645	COG0745	RESPONSE REGULATOR receiver
T303_06650	COG1126	abc transporter atp-binding protein
T303_06655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T303_06660	COG0765	amino acid transport
T303_06665	COG0765	amino acid transport
T303_06690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
T303_06700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
T303_06705	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
T303_06705	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
T303_06715	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
T303_06720	COG1956	GAF domain-containing protein
T303_06725	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
T303_06750	COG0038	chloride channel
T303_06760	COG0038	chloride channel
T303_06765	COG0716	FMN binding
T303_06840	COG0469	pyruvate kinase activity
T303_06890	COG0167	dihydroorotate dehydrogenase activity
T303_06900	COG0776	regulation of translation
T303_06910	COG2755	lipolytic protein G-D-S-L family
T303_06915	COG1307	EDD domain protein, DegV family
T303_06920	COG0497	DNA recombination
T303_06925	COG1438	arginine binding
T303_06930	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
T303_06945	COG1570	exodeoxyribonuclease VII activity
T303_06965	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
T303_06985	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
T303_06985	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
T303_06990	COG0300	oxidoreductase activity
T303_07015	COG0772	Belongs to the SEDS family
T303_07030	COG0107	imidazoleglycerol-phosphate synthase activity
T303_07040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
T303_07050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
T303_07080	COG2801	Transposase and inactivated derivatives
T303_07110	COG0647	UMP catabolic process
T303_07120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
T303_07155	COG1088	dTDP-glucose 4,6-dehydratase activity
T303_07165	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
T303_07170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
T303_07185	COG2384	SAM-dependent methyltransferase
T303_07195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
T303_07210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
T303_07215	COG3442	glutamine amidotransferase
T303_07220	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
T303_07220	COG0392	lysyltransferase activity
T303_07225	COG2267	carboxylic ester hydrolase activity
T303_07235	COG0488	(ABC) transporter
T303_07245	COG0513	Belongs to the DEAD box helicase family
T303_07280	COG0372	Belongs to the citrate synthase family
T303_07285	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
T303_07295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
T303_07300	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
T303_07305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
T303_07335	COG3764	Sortase (surface protein transpeptidase)
T303_07345	COG0039	L-malate dehydrogenase activity
T303_07355	COG0488	(ABC) transporter
T303_07380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T303_07385	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
T303_07385	COG1328	CTP reductase activity
T303_07415	COG1196	nuclear chromosome segregation
T303_07430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
T303_07445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
T303_07455	COG1011	Hydrolase
T303_07460	COG1760	l-serine dehydratase
T303_07495	COG2197	response regulator
T303_07500	COG4585	Histidine kinase
T303_07510	COG1131	(ABC) transporter
T303_07545	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
T303_07560	COG1131	(ABC) transporter
T303_07580	COG0577	efflux transmembrane transporter activity
T303_07585	COG1136	(ABC) transporter
T303_07590	COG0784	Response regulator, receiver
T303_07590	COG2198	Histidine kinase
T303_07590	COG5002	protein histidine kinase activity
T303_07595	COG0745	RESPONSE REGULATOR receiver
T303_07615	COG0534	Mate efflux family protein
T303_07620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
T303_07620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
T303_07640	COG0531	amino acid
T303_07650	COG2514	catechol 2,3-dioxygenase activity
T303_07655	COG1959	2 iron, 2 sulfur cluster binding
T303_07665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
T303_07670	COG0778	Nitroreductase
T303_07680	COG0656	L-ascorbic acid biosynthetic process
T303_07725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
T303_07750	COG1280	lysine exporter protein (LysE YggA)
T303_07765	COG1216	Glycosyl transferase, family 2
T303_07765	COG1442	glycosyl transferase family 8
T303_07770	COG0577	efflux transmembrane transporter activity
T303_07825	COG1396	sequence-specific DNA binding
T303_07830	COG2801	Transposase and inactivated derivatives
T303_07855	COG0419	ATPase involved in DNA repair
T303_07860	COG0420	3'-5' exonuclease activity
T303_07865	COG3250	beta-galactosidase activity
T303_07870	COG2211	Major facilitator Superfamily
T303_07870	COG2190	(PTS) system
T303_07875	COG2017	converts alpha-aldose to the beta-anomer
T303_07880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
T303_07895	COG1609	Transcriptional regulator
T303_07905	COG3064	Membrane
T303_07910	COG3064	Membrane
T303_07915	COG0488	(ABC) transporter
T303_07920	COG1132	(ABC) transporter
T303_07940	COG1523	belongs to the glycosyl hydrolase 13 family
T303_07965	COG0336	Belongs to the RNA methyltransferase TrmD family
T303_07985	COG2197	response regulator
T303_07990	COG4585	Histidine kinase
T303_08005	COG2815	serine threonine protein kinase
T303_08005	COG0515	serine threonine protein kinase
T303_08015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
T303_08015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
T303_08025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
T303_08040	COG0552	protein localization to endoplasmic reticulum
T303_08045	COG0561	phosphatase activity
T303_08050	COG0561	phosphatase activity
T303_08055	COG1725	Transcriptional regulator
T303_08060	COG1131	(ABC) transporter
T303_08070	COG4608	Belongs to the ABC transporter superfamily
T303_08075	COG0444	Belongs to the ABC transporter superfamily
T303_08080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T303_08085	COG0601	transmembrane transport
T303_08090	COG4166	transmembrane transport
T303_08100	COG4166	transmembrane transport
T303_08110	COG2801	Transposase and inactivated derivatives
T303_08120	COG0084	hydrolase, TatD family'
T303_08130	COG2801	Transposase and inactivated derivatives
T303_08140	COG0280	phosphate acetyltransferase
T303_08145	COG0564	pseudouridine synthase activity
T303_08155	COG2357	RelA SpoT domain protein
T303_08165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
T303_08170	COG1104	cysteine desulfurase activity
T303_08185	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
T303_08190	COG2003	Belongs to the UPF0758 family
T303_08215	COG1215	transferase activity, transferring glycosyl groups
T303_08230	COG1216	Glycosyl transferase, family 2
T303_08230	COG1442	glycosyl transferase family 8
T303_08245	COG0463	Glycosyl transferase, family 2
T303_08250	COG1091	dTDP-4-dehydrorhamnose reductase activity
T303_08260	COG0463	Glycosyl transferase, family 2
T303_08265	COG2151	metal-sulfur cluster biosynthetic enzyme
T303_08270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
T303_08275	COG0358	DNA primase activity
T303_08280	COG1970	mechanosensitive ion channel activity
T303_08300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T303_08305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T303_08310	COG1051	belongs to the nudix hydrolase family
T303_08335	COG0765	amino acid transport
T303_08340	COG1126	abc transporter atp-binding protein
T303_08360	COG1187	pseudouridine synthase activity
T303_08405	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
T303_08410	COG1518	maintenance of DNA repeat elements
T303_08415	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
T303_08420	COG0560	Phosphoserine phosphatase
T303_08430	COG0187	DNA topoisomerase II activity
T303_08440	COG1346	cytolysis
T303_08445	COG1380	Effector of murein hydrolase LrgA
T303_08455	COG1393	Belongs to the ArsC family
T303_08465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
T303_08495	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
T303_08500	COG1177	transmembrane transport
T303_08505	COG1176	ABC-type spermidine putrescine transport system, permease component I
T303_08545	COG0531	amino acid
T303_08550	COG0285	dihydrofolate synthase activity
T303_08555	COG1837	Belongs to the UPF0109 family
T303_08565	COG3615	Tellurite resistance protein tehB
T303_08565	COG0500	methyltransferase
T303_08580	COG0708	Exodeoxyribonuclease III
T303_08595	COG1597	lipid kinase activity
T303_08605	COG4708	membrane
T303_08615	COG0024	Methionine aminopeptidase
T303_08620	COG4109	DRTGG domain
T303_08630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
T303_08635	COG0658	competence protein
T303_08635	COG2333	competence protein COMEC
T303_08640	COG1555	photosystem II stabilization
T303_08640	COG1596	polysaccharide export
T303_08645	COG0204	Acyl-transferase
T303_08650	COG0726	polysaccharide deacetylase
T303_08655	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
T303_08665	COG0513	Belongs to the DEAD box helicase family
T303_08685	COG1396	sequence-specific DNA binding
T303_08690	COG2211	Major facilitator Superfamily
T303_08705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
T303_08720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T303_08725	COG1126	abc transporter atp-binding protein
T303_08730	COG0765	amino acid transport
T303_08750	COG2217	Heavy metal translocating P-type atpase
T303_08760	COG0159	tryptophan synthase activity
T303_08770	COG0135	phosphoribosylanthranilate isomerase activity
T303_08785	COG0512	Glutamine amidotransferase of anthranilate synthase
T303_08790	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
T303_08795	COG1605	Chorismate mutase
T303_08795	COG0287	Prephenate dehydrogenase
T303_08805	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
T303_08830	COG2176	DNA-directed DNA polymerase activity
T303_08840	COG2151	metal-sulfur cluster biosynthetic enzyme
T303_08850	COG2081	HI0933 family
T303_08875	COG1131	(ABC) transporter
T303_08880	COG0537	adenosine 5'-monophosphoramidase activity
T303_08915	COG2226	methyltransferase
T303_08920	COG0799	negative regulation of ribosome biogenesis
T303_08925	COG1713	HD superfamily hydrolase involved in NAD metabolism
T303_08930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
T303_08935	COG1534	Rna-binding protein
T303_08940	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
T303_08945	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
T303_08980	COG2723	6-phospho-beta-galactosidase activity
T303_09000	COG1335	isochorismatase
T303_09010	COG0436	Aminotransferase
T303_09015	COG0589	response to stress
T303_09035	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
T303_09040	COG1253	flavin adenine dinucleotide binding
T303_09045	COG1119	ATPase activity
T303_09050	COG0025	NhaP-type Na H and K H
T303_09060	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
T303_09065	COG1242	4 iron, 4 sulfur cluster binding
T303_09070	COG3480	Lon protease (S16) C-terminal proteolytic domain
T303_09075	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
T303_09080	COG0742	ribosomal rna small subunit methyltransferase
T303_09085	COG0492	ferredoxin-NADP+ reductase activity
T303_09095	COG1126	abc transporter atp-binding protein
T303_09105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T303_09120	COG1882	Formate acetyltransferase
T303_09145	COG0390	transport system, permease component
T303_09150	COG4619	ABC transporter
T303_09160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
T303_09175	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
T303_09210	COG2801	Transposase and inactivated derivatives
T303_09275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
T303_09295	COG1132	(ABC) transporter
T303_09300	COG1132	(ABC) transporter
T303_09315	COG0820	rRNA (adenine-C2-)-methyltransferase activity
T303_09320	COG4470	Protein conserved in bacteria
T303_09325	COG0737	Belongs to the 5'-nucleotidase family
T303_09335	COG0513	Belongs to the DEAD box helicase family
T303_09345	COG0768	penicillin binding
T303_09370	COG3152	Membrane
T303_09395	COG4152	abc transporter atp-binding protein
T303_09400	COG1811	Na channel or pump
T303_09410	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
T303_09445	COG0561	phosphatase activity
T303_09450	COG0252	asparaginase activity
T303_09460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
T303_09465	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
T303_09475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
T303_09480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
T303_09495	COG1482	cell wall glycoprotein biosynthetic process
T303_09500	COG1940	carbohydrate kinase activity
T303_09505	COG1263	PTS System
T303_09505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T303_09505	COG2190	(PTS) system
T303_09510	COG1621	beta-fructofuranosidase activity
T303_09515	COG1609	Transcriptional regulator
T303_09535	COG2131	deaminase
T303_09540	COG0006	proline dipeptidase activity
T303_09635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
T303_09635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
T303_09660	COG0681	Belongs to the peptidase S26 family
T303_09665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
T303_09675	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
T303_09685	COG0456	acetyltransferase
T303_09690	COG1214	PFAM Peptidase M22, glycoprotease
T303_09710	COG0174	glutamine synthetase
T303_09715	COG0789	Transcriptional regulator
T303_09740	COG1943	Transposase
T303_09750	COG2801	Transposase and inactivated derivatives
T303_09755	COG2801	Transposase and inactivated derivatives
T303_09785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
T303_09795	COG1322	Protein conserved in bacteria
T303_09830	COG0084	hydrolase, TatD family'
T303_09835	COG1832	CoA-binding protein
T303_09840	COG3118	belongs to the thioredoxin family
T303_09895	COG1943	Transposase