locus-tag class description HUT09_00130 ENOG4105ECQ AraC Family Transcriptional Regulator HUT09_00215 ENOG4107T94 Endo-14-beta-xylanase HUT09_00235 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT09_00250 ENOG4105D2S major facilitator superfamily HUT09_00260 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase HUT09_00285 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT09_00305 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HUT09_00385 ENOG4105BZU Histidine kinase HUT09_00400 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HUT09_00460 ENOG4108IG5 Transcriptional regulator HUT09_00465 ENOG4105EYF MMPL domain protein HUT09_00510 ENOG41065SU Two-component system sensor kinase HUT09_00515 ENOG4108KXV response regulator HUT09_00590 ENOG4105CR4 methylisocitrate lyase HUT09_00595 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT09_00605 ENOG4105K56 Transcriptional regulator HUT09_00610 ENOG4108ZHJ Organic hydroperoxide resistance protein HUT09_00625 ENOG4105CHR reductase HUT09_00655 ENOG4105CQB FAD linked oxidase domain protein HUT09_00665 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT09_00670 ENOG4105YVS arsR family transcriptional regulator HUT09_00675 ENOG4105DQ4 alcohol dehydrogenase HUT09_00700 ENOG41064MX Tetr family transcriptional regulator HUT09_00720 ENOG4105DHQ Histidine kinase HUT09_00750 ENOG4105CG3 alpha amylase, catalytic region HUT09_00755 ENOG4105DRS transport system, permease HUT09_00760 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT09_00765 ENOG4105XN3 extracellular solute-binding protein family 1 HUT09_00820 ENOG410804X Transcriptional regulator HUT09_00825 ENOG4105DE4 1-phosphofructokinase HUT09_00830 ENOG4105DM4 PTS System HUT09_00835 ENOG4107QYR Signal peptidase i HUT09_00900 ENOG4105NRA 50s ribosomal protein l31 type b HUT09_00935 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein HUT09_00965 ENOG4105E39 Enoyl-CoA hydratase HUT09_00985 ENOG4105EAB amino acid AbC transporter HUT09_00990 ENOG4105E5Q amino acid AbC transporter HUT09_01000 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_01030 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_01040 ENOG4108A04 Beta-lactamase HUT09_01070 ENOG4105PDP Short chain dehydrogenase HUT09_01080 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT09_01085 ENOG4108UYE Lactoylglutathione lyase HUT09_01095 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HUT09_01100 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT09_01115 ENOG4105C0W non-ribosomal peptide synthetase HUT09_01120 ENOG4105X7H acyl-CoA dehydrogenase HUT09_01125 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HUT09_01140 ENOG4108K8S endonuclease I HUT09_01145 ENOG4105CSV Glutaminase HUT09_01160 ENOG4108JQ1 Dehydrogenase HUT09_01165 ENOG4107QRI Phosphoketolase HUT09_01180 ENOG4105C7W Xanthine dehydrogenase HUT09_01185 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HUT09_01190 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HUT09_01250 ENOG4105M2Z protein tyrosine serine phosphatase HUT09_01275 ENOG4105E0A ABC, transporter HUT09_01280 ENOG4108MES Periplasmic binding protein HUT09_01290 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_01300 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT09_01305 ENOG4105E93 esterase HUT09_01310 ENOG4105TVJ transport system, permease HUT09_01315 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HUT09_01320 ENOG4105E4F Isochorismate synthase HUT09_01325 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HUT09_01330 ENOG4105WQI isochorismatase HUT09_01335 ENOG4105WQI isochorismatase HUT09_01350 ENOG4105C3U ABC transporter HUT09_01395 ENOG4105E2D ec 3.2.1.52 HUT09_01415 ENOG4107R9S Malate synthase HUT09_01450 ENOG4105BZ1 (ABC) transporter HUT09_01470 ENOG4108R5T secreted protein HUT09_01480 ENOG4105EGE secreted protein HUT09_01490 ENOG4105CPQ Dehydrogenase HUT09_01495 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HUT09_01540 ENOG4108YV4 Universal stress protein HUT09_01550 ENOG4105E93 esterase HUT09_01555 ENOG4105BZ1 (ABC) transporter HUT09_01565 ENOG4105BZ1 (ABC) transporter HUT09_01570 ENOG4108HUF Transporter HUT09_01575 ENOG4105E0A ABC, transporter HUT09_01580 ENOG4105TVJ transport system, permease HUT09_01585 ENOG4105DQ5 transport system permease protein HUT09_01620 ENOG4105F4R Transcriptional regulator mode HUT09_01640 ENOG41082YX Transcriptional regulator, arsr family HUT09_01675 ENOG4105BZ1 (ABC) transporter HUT09_01700 ENOG4105CPF Cell wall formation (By similarity) HUT09_01720 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HUT09_01725 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT09_01730 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUT09_01740 ENOG41085FC arsR family transcriptional regulator HUT09_01745 ENOG4108J2R molybdopterin oxidoreductase HUT09_01765 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUT09_01770 ENOG4105C8U phosphate abc transporter HUT09_01775 ENOG4105CVA phosphate HUT09_01795 ENOG41082YX Transcriptional regulator, arsr family HUT09_01810 ENOG4105H3G oxidoreductase HUT09_01825 ENOG4105HS2 Arsenate reductase HUT09_01830 ENOG4105CMT Dihydroxyacetone kinase HUT09_01835 ENOG4108UTZ Dihydroxyacetone kinase HUT09_01880 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_01890 ENOG4105DWV Homoserine O-trans-acetylase HUT09_01910 ENOG4105E0A ABC, transporter HUT09_01915 ENOG4105EHG Permease protein HUT09_01950 ENOG4105D7K pfkb domain protein HUT09_01990 ENOG4107S2Z UPF0761 membrane protein HUT09_02010 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT09_02015 ENOG41065KQ synthase HUT09_02025 ENOG4105E0A ABC, transporter HUT09_02030 ENOG4105TVJ transport system, permease HUT09_02035 ENOG4105DQ5 transport system permease protein HUT09_02055 ENOG41067SE Tetr family transcriptional regulator HUT09_02080 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HUT09_02090 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HUT09_02095 ENOG4105ETE Transcriptional regulator (LacI family HUT09_02100 ENOG4105CNN ABC, transporter HUT09_02105 ENOG4107R9N ABC transporter HUT09_02110 ENOG4105C2J ABC transporter HUT09_02115 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HUT09_02145 ENOG4105IDI abc transporter atp-binding protein HUT09_02195 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT09_02200 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HUT09_02210 ENOG4105BZ1 (ABC) transporter HUT09_02220 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HUT09_02230 ENOG4105EQD regulatoR HUT09_02235 ENOG4105DQ5 transport system permease protein HUT09_02240 ENOG4108U1V ABC transporter, permease HUT09_02245 ENOG4105E0A ABC, transporter HUT09_02285 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT09_02290 ENOG4105CSH Transporter HUT09_02340 ENOG4106F1P AAA ATPase, central domain protein HUT09_02350 ENOG4105MVE transcriptional regulator HUT09_02365 ENOG4105CGD Nad-dependent epimerase dehydratase HUT09_02375 ENOG4105C6T cysteine synthase HUT09_02390 ENOG4105DKQ ROK family HUT09_02395 ENOG4106UW1 Major Facilitator superfamily HUT09_02425 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HUT09_02430 ENOG4107PP3 Acetylornithine deacetylase HUT09_02440 ENOG4105I1F Resistance protein HUT09_02465 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUT09_02470 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUT09_02475 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HUT09_02495 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HUT09_02500 ENOG4105CMT Dihydroxyacetone kinase HUT09_02505 ENOG4105CMT Dihydroxyacetone kinase HUT09_02510 ENOG4105C0X amino acid HUT09_02520 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HUT09_02525 ENOG41060NJ transcriptional regulator HUT09_02550 ENOG4105C10 Electron transfer flavoprotein HUT09_02595 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HUT09_02600 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT09_02615 ENOG410841Q phosphoesterase PA-phosphatase related protein HUT09_02640 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) HUT09_02665 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUT09_02680 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HUT09_02695 ENOG4107VXZ Hydrolase HUT09_02700 ENOG4105D9P serine threonine protein kinase HUT09_02705 ENOG4107SET aldo keto reductase HUT09_02710 ENOG4106UDK Cellulose-binding, family II HUT09_02720 ENOG4105DQE DNA ligase HUT09_02745 ENOG4105C37 (CBS) domain HUT09_02780 ENOG4108Z86 Glutamine amidotransferase HUT09_02785 ENOG4105CUB amino acid HUT09_02790 ENOG41073TP transcriptional regulator HUT09_02795 ENOG4105C5F glutamine synthetase HUT09_02800 ENOG4105C26 Dehydrogenase HUT09_02835 ENOG41073B4 coagulation factor 5 8 type domain-containing protein HUT09_02855 ENOG4105W49 UPF0434 protein HUT09_02870 ENOG4108WYP Transcriptional regulator HUT09_02880 ENOG4105DZC cytosine deaminase HUT09_02895 ENOG4105DQ5 transport system permease protein HUT09_02900 ENOG4105TVJ transport system, permease HUT09_02905 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUT09_02910 ENOG4105BZ1 (ABC) transporter HUT09_02925 ENOG4107R72 Ceramidase HUT09_02945 ENOG4105DDN Pentapeptide repeat-containing protein HUT09_02955 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) HUT09_02980 ENOG4107XGZ Hydrolase HUT09_03020 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_03045 ENOG4105F76 Sarcosine oxidase HUT09_03060 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HUT09_03065 ENOG4105TVJ transport system, permease HUT09_03070 ENOG4105DQ5 transport system permease protein HUT09_03080 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HUT09_03115 ENOG4105DXX methyltransferase HUT09_03120 ENOG4105NGS secreted protein HUT09_03140 ENOG4105DWY Agmatine deiminase HUT09_03150 ENOG4105C3U ABC transporter HUT09_03155 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_03165 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT09_03170 ENOG4105DWY Agmatine deiminase HUT09_03175 ENOG4105CQM Urea amidohydrolase subunit alpha HUT09_03190 ENOG4107TPY serine threonine protein kinase HUT09_03200 ENOG4105DWY Agmatine deiminase HUT09_03225 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_03230 ENOG4107ZED Uncharacterised protein family UPF0047 HUT09_03235 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT09_03240 ENOG4105E2Y ABC, transporter HUT09_03250 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUT09_03255 ENOG4105H3G oxidoreductase HUT09_03270 ENOG4105BZ1 (ABC) transporter HUT09_03275 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HUT09_03280 ENOG4105CQB FAD linked oxidase domain protein HUT09_03285 ENOG4105EPC oxidoreductase HUT09_03290 ENOG4105BZ1 (ABC) transporter HUT09_03295 ENOG4105BZ1 (ABC) transporter HUT09_03320 ENOG4105CEP NADH dehydrogenase HUT09_03325 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) HUT09_03340 ENOG4105C29 acyl-CoA thioesterase HUT09_03350 ENOG4105BZP glycoside hydrolase 15-related HUT09_03365 ENOG4105VCT ion-transport protein YfeO HUT09_03375 ENOG4108V06 Glutathione peroxidase HUT09_03380 ENOG4105C1G acyl-Coa dehydrogenase HUT09_03390 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT09_03400 ENOG4105F1K Glutamine amidotransferase HUT09_03405 ENOG4105CTQ phosphohexokinase HUT09_03420 ENOG4105F6E Acyl-transferase HUT09_03440 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HUT09_03450 ENOG4105CQM Urea amidohydrolase subunit alpha HUT09_03455 ENOG4105KI2 Urea amidohydrolase subunit beta HUT09_03460 ENOG4108YZ9 Urea amidohydrolase subunit gamma HUT09_03465 ENOG4108Q5F Tetr family transcriptional regulator HUT09_03495 ENOG4107SN7 NLP P60 protein HUT09_03500 ENOG4105N14 lysine exporter protein LysE YggA HUT09_03505 ENOG4108M0I Transcriptional regulator HUT09_03530 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HUT09_03535 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT09_03540 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HUT09_03815 ENOG4105C83 adenylosuccinate lyase HUT09_03820 ENOG4108VCA G U mismatch-specific DNA glycosylase HUT09_03830 ENOG4105DKQ ROK family HUT09_03835 ENOG4105FDP GntR family transcriptional regulator HUT09_03840 ENOG4108KPJ rna polymerase sigma factor HUT09_03845 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HUT09_03855 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT09_03910 ENOG4105EYH Exonuclease HUT09_03920 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HUT09_03925 ENOG4105K4P CoA-binding domain protein HUT09_03950 ENOG4108Z0R Transferase HUT09_03965 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HUT09_03970 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUT09_03990 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HUT09_04045 ENOG4107RI4 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HUT09_04050 ENOG4105EP9 oxidoreductase HUT09_04070 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUT09_04080 ENOG4105CHR reductase HUT09_04100 ENOG4105C3M thioredoxin reductase HUT09_04105 ENOG4105CUX Signal transduction histidine kinase HUT09_04130 ENOG4105JQN Transcriptional regulator HUT09_04135 ENOG4108Q5Y Membrane HUT09_04140 ENOG4105CSW GntR family transcriptional regulator HUT09_04220 ENOG4105JAB phenazine biosynthesis protein, phzf family HUT09_04250 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HUT09_04260 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUT09_04280 ENOG4108UW8 fha domain-containing protein HUT09_04330 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HUT09_04340 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT09_04355 ENOG4108UQS dipeptidase HUT09_04385 ENOG4105GWZ Roadblock lc7 family protein HUT09_04430 ENOG4105JXB ankyrin repeat-containing protein HUT09_04450 ENOG4108VW9 Membrane HUT09_04460 ENOG4105DEU major facilitator superfamily HUT09_04465 ENOG4105Q70 HUT09_04470 ENOG4105FS0 cytoplasmic membrane protein HUT09_04475 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT09_04485 ENOG4105EW9 transcriptional regulator AsnC family HUT09_04495 ENOG4105C1G acyl-Coa dehydrogenase HUT09_04550 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HUT09_04555 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HUT09_04560 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HUT09_04565 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HUT09_04605 ENOG4105C2W permease HUT09_04635 ENOG4105C26 Dehydrogenase HUT09_04650 ENOG4105DKT Transcriptional regulator HUT09_04655 ENOG4105DJV ribulose-phosphate 3-epimerase HUT09_04665 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HUT09_04680 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUT09_04690 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HUT09_04705 ENOG4105SKN orotidine 5''-phosphate decarboxylase HUT09_04710 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HUT09_04715 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HUT09_04720 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HUT09_04730 ENOG4105CD3 dihydroorotase HUT09_04735 ENOG4105CXT aspartate transcarbamylase HUT09_04740 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HUT09_04750 ENOG410803B Involved in the transcription termination process (By similarity) HUT09_04755 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HUT09_04760 ENOG4105DC7 peptidase M24 HUT09_04770 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HUT09_04775 ENOG4105D49 3-dehydroquinate synthase HUT09_04780 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HUT09_04785 ENOG4105E2X shikimate dehydrogenase HUT09_04795 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HUT09_04800 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUT09_04820 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUT09_04840 ENOG4105CUT histidyl-tRNA synthetase HUT09_04855 ENOG4105C99 atpase involved in dna repair HUT09_04860 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUT09_04865 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HUT09_04870 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT09_04875 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT09_04885 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT09_04890 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HUT09_04895 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HUT09_04900 ENOG4105CDY transcriptional regulatory protein HUT09_04905 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HUT09_04910 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HUT09_04920 ENOG4105E2K Glycosyl transferase (Group 1 HUT09_04925 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase HUT09_04955 ENOG4105C22 threonyL-tRNA synthetase HUT09_04970 ENOG4108IRC dna polymerase iii HUT09_04995 ENOG4105KF0 sporulation and cell division protein, SsgA HUT09_05030 ENOG4105CRQ synthase (Component I) HUT09_05085 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUT09_05090 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUT09_05105 ENOG4105D01 (LipO)protein HUT09_05110 ENOG4108UMI ABC transporter, permease HUT09_05115 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HUT09_05150 ENOG4105C57 major facilitator superfamily HUT09_05155 ENOG4105RJZ Transcriptional regulator HUT09_05165 ENOG4105EEM helicase HUT09_05175 ENOG4105CH7 arginosuccinase HUT09_05180 ENOG4105CDH Citrulline--aspartate ligase HUT09_05200 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HUT09_05205 ENOG4105C8Y Acetylornithine aminotransferase HUT09_05210 ENOG4105CAS nag kinase HUT09_05215 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HUT09_05220 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HUT09_05230 ENOG4105C09 Bile acid HUT09_05280 ENOG4105T38 integral membrane protein HUT09_05290 ENOG4105F32 YngK protein HUT09_05310 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HUT09_05315 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HUT09_05320 ENOG4105BZU Histidine kinase HUT09_05325 ENOG4108RWN rrna methyltransferase HUT09_05330 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HUT09_05335 ENOG41084BS 50S ribosomal protein L35 HUT09_05340 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HUT09_05400 ENOG4108IJ7 Glycine betaine HUT09_05405 ENOG4105HFS 5'-3' exonuclease HUT09_05430 ENOG4105K6V RNA polymerase HUT09_05435 ENOG4105RNG membrane HUT09_05440 ENOG4105CVP deoxyribo-dipyrimidine photolyase HUT09_05450 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT09_05455 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT09_05495 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HUT09_05500 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HUT09_05520 ENOG4108FFZ Transcriptional regulator HUT09_05530 ENOG4108V1T peptidylprolyl cis-trans isomerase HUT09_05535 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HUT09_05545 ENOG4105ETE Transcriptional regulator (LacI family HUT09_05550 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT09_05555 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT09_05565 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HUT09_05570 ENOG4105E5F proteasome HUT09_05575 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HUT09_05605 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_05610 ENOG4108J59 Extracellular solute-binding protein, family 5 HUT09_05620 ENOG4105C3R Methionine synthase HUT09_05625 ENOG4108K8U Glycerol operon regulatory protein HUT09_05630 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUT09_05635 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT09_05640 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HUT09_05645 ENOG4105DEN Luciferase family HUT09_05660 ENOG4105C8N cysteinyl-tRNA synthetase HUT09_05680 ENOG4105D7N magnesium and cobalt transport protein CorA HUT09_05690 ENOG4105DYW oxidoreductase HUT09_05695 ENOG4105CPC Aldo Keto reductase HUT09_05725 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT09_05735 ENOG4105D3G Pseudouridine synthase HUT09_05750 ENOG4105C6F GntR Family Transcriptional Regulator HUT09_05755 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HUT09_05760 ENOG4105C6Z Gluconate HUT09_05780 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein HUT09_05785 ENOG4105PTV Nudix Hydrolase HUT09_05790 ENOG4105VG5 Membrane HUT09_05800 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT09_05805 ENOG4105EQX glucarate dehydratase HUT09_05815 ENOG4105C1G acyl-Coa dehydrogenase HUT09_05820 ENOG4105IIU Aminopeptidase HUT09_05825 ENOG4108IG5 Transcriptional regulator HUT09_05830 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_05840 ENOG4105EHZ conserved protein UCP016719 HUT09_05860 ENOG4108Z4X TRANSCRIPTIONal HUT09_05870 ENOG4108IV0 ABC, transporter HUT09_05875 ENOG4105C0Z ABC transporter HUT09_05885 ENOG4105C32 Amino acid ABC transporter (Permease) HUT09_05890 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HUT09_05915 ENOG4105C1G acyl-Coa dehydrogenase HUT09_05925 ENOG4107Y9U Membrane HUT09_05930 ENOG4105CSR polyphosphate kinase 2 HUT09_05945 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT09_05955 ENOG4105D4T Citrate transporter HUT09_05960 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT09_05965 ENOG4108SGK Tetr family transcriptional regulator HUT09_05970 ENOG4105F1J Homogentisate 1,2-dioxygenase HUT09_05995 ENOG4108TCJ secreted hydrolase HUT09_06005 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HUT09_06020 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT09_06040 ENOG4106YYS transcriptional regulatory protein HUT09_06045 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT09_06070 ENOG4107IFA Lipase (EC 3.1.1.3) HUT09_06075 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUT09_06080 ENOG4105C0B DNA polymerase III (alpha subunit) HUT09_06140 ENOG4106NMR serine protease HUT09_06160 ENOG4105EAB amino acid AbC transporter HUT09_06180 ENOG4105E5Q amino acid AbC transporter HUT09_06185 ENOG4105EAB amino acid AbC transporter HUT09_06195 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HUT09_06200 ENOG4105C1G acyl-Coa dehydrogenase HUT09_06205 ENOG4105C57 major facilitator superfamily HUT09_06210 ENOG410841Q phosphoesterase PA-phosphatase related protein HUT09_06225 ENOG4105CPK Glycosyl transferase (Group 1 HUT09_06240 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HUT09_06250 ENOG4105CAT Cytidine monophosphate kinase HUT09_06290 ENOG410756H nucleotidyltransferase HUT09_06315 ENOG4105FE9 pseudouridine synthase HUT09_06320 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HUT09_06325 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HUT09_06340 ENOG4105DCF alanine dehydrogenase HUT09_06355 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HUT09_06360 ENOG4105BZP glycoside hydrolase 15-related HUT09_06375 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HUT09_06380 ENOG4105CBG Sulfatase HUT09_06385 ENOG4105E6M Sulphatase-modifying factor protein HUT09_06395 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_06435 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HUT09_06440 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUT09_06460 ENOG4105E0A ABC, transporter HUT09_06465 ENOG4105DSU hydrolase HUT09_06495 ENOG4108VX5 3-methyladenine DNA glycosylase HUT09_06505 ENOG4108V1U phospholipid-binding protein HUT09_06530 ENOG4105DKW ABC transporter HUT09_06545 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_06550 ENOG4108XG2 Histidine kinase HUT09_06560 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HUT09_06570 ENOG4105IDI abc transporter atp-binding protein HUT09_06575 ENOG4105EAC phosphoserine phosphatase HUT09_06595 ENOG4107YCY Transcriptional regulator HUT09_06605 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HUT09_06610 ENOG4105CHR reductase HUT09_06625 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HUT09_06645 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT09_06650 ENOG4107QN1 sodium solute HUT09_06665 ENOG4105E2A Dehydrogenase HUT09_06700 ENOG4105BZP glycoside hydrolase 15-related HUT09_06730 ENOG4105VBF alkaline shock protein HUT09_06740 ENOG4106YT9 Enoyl-CoA hydratase HUT09_06750 ENOG4105C5H ABC transporter HUT09_06775 ENOG4107W7X Aldolase HUT09_06790 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HUT09_06795 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUT09_06810 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUT09_06835 ENOG4105C3J Cysteine desulfurase HUT09_06865 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT09_06870 ENOG41067TZ transcriptional regulator, MarR family HUT09_06895 ENOG4107HP6 Transcriptional regulator HUT09_06910 ENOG4105BZU Histidine kinase HUT09_06915 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_06920 ENOG4105CJN penicillin-binding protein HUT09_06925 ENOG4105C7N Xanthine uracil vitamin C permease HUT09_06940 ENOG4105FBW Monooxygenase HUT09_06960 ENOG4105FBW Monooxygenase HUT09_06965 ENOG4105C5Q Transcriptional regulator HUT09_07000 ENOG4108762 serine threonine protein kinase HUT09_07005 ENOG4108762 serine threonine protein kinase HUT09_07025 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT09_07030 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HUT09_07035 ENOG4108RFG Tetr family transcriptional regulator HUT09_07055 ENOG4105VG1 fes assembly suf system protein HUT09_07060 ENOG4108UNV SUF system FeS assembly protein, NifU family HUT09_07065 ENOG4105C9B Cysteine desulfurase HUT09_07070 ENOG4105C3K feS assembly ATPase SufC HUT09_07080 ENOG4105JRK feS assembly protein SufD HUT09_07095 ENOG4105CJ1 ABC, transporter HUT09_07115 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HUT09_07125 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HUT09_07140 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) HUT09_07150 ENOG4105K7W phage-related replication protein HUT09_07165 ENOG4107QP8 phosphohexose isomerase HUT09_07180 ENOG4105CP7 Triose-phosphate isomerase HUT09_07185 ENOG4105BZA Phosphoglycerate kinase HUT09_07190 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HUT09_07195 ENOG4105CIE May be required for sporulation (By similarity) HUT09_07200 ENOG4105CHW UPF0052 protein HUT09_07205 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HUT09_07210 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HUT09_07235 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT09_07265 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HUT09_07275 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HUT09_07280 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT09_07290 ENOG4108HH4 Major Facilitator Superfamily HUT09_07300 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HUT09_07320 ENOG4105CHM Aminotransferase HUT09_07340 ENOG4105C0D helicase HUT09_07360 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HUT09_07380 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT09_07385 ENOG4105CQ7 ATP-dependent helicase HUT09_07420 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HUT09_07430 ENOG4105C32 Amino acid ABC transporter (Permease) HUT09_07435 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HUT09_07440 ENOG4105C0Z ABC transporter HUT09_07445 ENOG4108IV0 ABC, transporter HUT09_07475 ENOG4105CGH 5'-nucleotidase HUT09_07495 ENOG4105CHH sulfate transporter HUT09_07505 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HUT09_07520 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUT09_07525 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HUT09_07540 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HUT09_07560 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HUT09_07565 ENOG41060WC Enoyl-CoA hydratase HUT09_07580 ENOG4105EA8 2-Nitropropane dioxygenase HUT09_07585 ENOG4105C1J atp-dependent rna helicase HUT09_07590 ENOG4105VEQ Cold shock protein HUT09_07595 ENOG4105CHU acetyl-coa acetyltransferase HUT09_07600 ENOG4108RZE Tetr family transcriptional regulator HUT09_07605 ENOG4105CHR reductase HUT09_07610 ENOG4105CC9 acyl-Coa dehydrogenase HUT09_07615 ENOG4105C1G acyl-Coa dehydrogenase HUT09_07625 ENOG41090B9 response to stress HUT09_07630 ENOG4105MUA Resistance protein HUT09_07645 ENOG4105CBC glutamate synthase HUT09_07655 ENOG41065RQ ADP-ribosylation crystallin J1 HUT09_07675 ENOG4108RVA ribokinase HUT09_07680 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT09_07690 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HUT09_07700 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HUT09_07705 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HUT09_07715 ENOG4105DK0 Indole-3-glycerol phosphate synthase HUT09_07735 ENOG4105CRQ synthase (Component I) HUT09_07740 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HUT09_07750 ENOG4105G9B Transcriptional regulator HUT09_07765 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HUT09_07770 ENOG4108176 endoribonuclease L-psp HUT09_07775 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HUT09_07780 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HUT09_07790 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HUT09_07795 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT09_07800 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HUT09_07820 ENOG4108Z66 YbaK ebsC protein HUT09_07850 ENOG4105C0B DNA polymerase III (alpha subunit) HUT09_07900 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HUT09_07910 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HUT09_07915 ENOG4107VQS DivIVA family HUT09_07925 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HUT09_07930 ENOG4105DFA alanine racemase domain protein HUT09_07935 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HUT09_07940 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HUT09_07945 ENOG4105ME9 cell division protein FtsQ HUT09_07950 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HUT09_07960 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HUT09_07965 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HUT09_07975 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HUT09_07980 ENOG4105CJN penicillin-binding protein HUT09_07990 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HUT09_08000 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT09_08020 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HUT09_08030 ENOG4107T0D ABC, transporter HUT09_08035 ENOG4105ECB domain protein HUT09_08050 ENOG4105EWK phytoene HUT09_08065 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HUT09_08095 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HUT09_08105 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HUT09_08115 ENOG4108UQY Iron-storage protein HUT09_08125 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HUT09_08140 ENOG4105C5I Dehydrogenase HUT09_08150 ENOG4105ENE Histidine kinase HUT09_08175 ENOG4105DKQ ROK family HUT09_08185 ENOG4105D0U Arsenite-activated ATPase (ArsA) HUT09_08255 ENOG4108I0Q anthranilate phosphoribosyltransferase HUT09_08260 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HUT09_08265 ENOG4107EUI c reductase, iron-sulfur HUT09_08270 ENOG4107UDY cytochrome C HUT09_08275 ENOG4105CCU oxidase (Subunit III) HUT09_08285 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT09_08290 ENOG4105MCD Part of cytochrome c oxidase, its function is HUT09_08295 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT09_08300 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HUT09_08305 ENOG4107QI6 Cysteine desulfurase HUT09_08310 ENOG4107T4Z adenosine kinase HUT09_08330 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HUT09_08345 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_08350 ENOG4105BZU Histidine kinase HUT09_08370 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT09_08375 ENOG4105C0H protease HUT09_08385 ENOG4108YZT Adenosylcobinamide kinase HUT09_08390 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUT09_08395 ENOG4105CRK lysyL-tRNA synthetase HUT09_08415 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HUT09_08435 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT09_08455 ENOG4105ECP epimerase HUT09_08470 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT09_08475 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HUT09_08505 ENOG4105UA4 acetyltransferase HUT09_08520 ENOG4108222 arsenate reductase HUT09_08525 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT09_08530 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT09_08550 ENOG4107R5B glutamine synthetase HUT09_08555 ENOG4107NHD transcriptional regulator HUT09_08560 ENOG4107R13 MMPL domain protein HUT09_08565 ENOG4108XG2 Histidine kinase HUT09_08570 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_08630 ENOG4105CG3 alpha amylase, catalytic region HUT09_08635 ENOG4105EG2 ABC transporter, permease HUT09_08650 ENOG4105ETE Transcriptional regulator (LacI family HUT09_08665 ENOG4105CUB amino acid HUT09_08675 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HUT09_08685 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT09_08695 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT09_08725 ENOG4105C5F glutamine synthetase HUT09_08750 ENOG4107R16 Multicopper oxidase HUT09_08755 ENOG4105C4K Nad synthetase HUT09_08760 ENOG4105F27 Major Facilitator HUT09_08775 ENOG4105C57 major facilitator superfamily HUT09_08780 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HUT09_08800 ENOG4107XZ0 Peptidase M50 HUT09_08845 ENOG4105JAB phenazine biosynthesis protein, phzf family HUT09_08860 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HUT09_08865 ENOG4105EHG Permease protein HUT09_08870 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUT09_08875 ENOG4106A0S HUT09_08890 ENOG4105CIK Amidinotransferase HUT09_08905 ENOG4105C2C drug resistance transporter, Bcr CflA HUT09_08915 ENOG4105DGI Alkaline phosphatase HUT09_08930 ENOG4105JAB phenazine biosynthesis protein, phzf family HUT09_08960 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT09_08990 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HUT09_08995 ENOG4107XFJ UPF0246 protein HUT09_09000 ENOG4108UHU Aldolase HUT09_09020 ENOG4105EGD dinuclear metal center protein, YbgI family HUT09_09040 ENOG4105CHR reductase HUT09_09060 ENOG4105CHU acetyl-coa acetyltransferase HUT09_09065 ENOG4105D2B acyl-CoA dehydrogenase HUT09_09070 ENOG4107QZF nitrite reductase NADPH large subunit HUT09_09075 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HUT09_09080 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT09_09085 ENOG4107QND Nitrite extrusion protein HUT09_09110 ENOG4105DYW oxidoreductase HUT09_09135 ENOG4107QVI Methyltransferase, type 11 HUT09_09140 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT09_09145 ENOG4108SGK Tetr family transcriptional regulator HUT09_09215 ENOG4105BZ1 (ABC) transporter HUT09_09225 ENOG4105F2C Acetyl-CoA acetyltransferase HUT09_09230 ENOG4106A3M Cytochrome p-450 HUT09_09265 ENOG4105C4B ABC transporter, permease HUT09_09280 ENOG4105NQG DoxX HUT09_09360 ENOG4105DAX Pfam:DUF2983 HUT09_09405 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT09_09435 ENOG4105BZU Histidine kinase HUT09_09440 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_09455 ENOG4105CPC Aldo Keto reductase HUT09_09460 ENOG4105VUF Transcriptional regulator HUT09_09500 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT09_09505 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT09_09525 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HUT09_09535 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUT09_09540 ENOG4108R86 Transcriptional regulator HUT09_09545 ENOG4105N14 lysine exporter protein LysE YggA HUT09_09550 ENOG4105EXN Sulfate transport protein CysZ HUT09_09555 ENOG4108ZHJ Organic hydroperoxide resistance protein HUT09_09560 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT09_09590 ENOG4108XM1 transcriptional regulator AsnC family HUT09_09605 ENOG4107MM9 BNR Asp-box repeat-containing protein HUT09_09610 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_09615 ENOG4105D8K carboxyl transferase HUT09_09620 ENOG4108IND Tetr family transcriptional regulator HUT09_09625 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HUT09_09655 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT09_09675 ENOG4105C1G acyl-Coa dehydrogenase HUT09_09695 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HUT09_09700 ENOG4106IBS oxygenase HUT09_09710 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_09795 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_09800 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HUT09_09805 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT09_09815 ENOG4105C57 major facilitator superfamily HUT09_09825 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HUT09_09835 ENOG4108UB4 uncharacterized protein ygjQ HUT09_09840 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT09_09885 ENOG4108IFG nitrite reductase, (NAD(P)H) HUT09_09890 ENOG4107QZF nitrite reductase NADPH large subunit HUT09_09915 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT09_09925 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT09_09930 ENOG4108UMI ABC transporter, permease HUT09_09945 ENOG4108TZY GntR Family Transcriptional Regulator HUT09_09960 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_09975 ENOG4108FN7 Aldo keto reductase HUT09_10015 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT09_10025 ENOG4105CSV Glutaminase HUT09_10035 ENOG4105VMP Transcriptional regulator HUT09_10055 ENOG4105D74 hydrolase HUT09_10075 ENOG4105BZU Histidine kinase HUT09_10080 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HUT09_10180 ENOG4105PDP Short chain dehydrogenase HUT09_10210 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HUT09_10235 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HUT09_10245 ENOG4105FDK ABC transporter HUT09_10260 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUT09_10265 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HUT09_10280 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT09_10285 ENOG4105D4Y metalloprotease HUT09_10295 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HUT09_10315 ENOG4105MSB protein, conserved in bacteria HUT09_10325 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HUT09_10335 ENOG4107UEK pfkb domain protein HUT09_10350 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HUT09_10355 ENOG4107YU2 histidine triad (hIT) protein HUT09_10370 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT09_10375 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HUT09_10405 ENOG4108IQE Amp-dependent synthetase and ligase HUT09_10410 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HUT09_10415 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HUT09_10450 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HUT09_10455 ENOG4105EPR degv family HUT09_10465 ENOG4105C8T Leucyl-tRNA synthetase HUT09_10475 ENOG4107QIZ NADH dehydrogenase HUT09_10500 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT09_10515 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HUT09_10530 ENOG4105D0M Protease HtpX homolog HUT09_10545 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HUT09_10555 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HUT09_10560 ENOG4107SJB teichoic acid biosynthesis HUT09_10580 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HUT09_10585 ENOG4105K46 50S ribosomal protein l27 HUT09_10590 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HUT09_10595 ENOG4105J5G Transferase hexapeptide repeat containing protein HUT09_10605 ENOG4108IJ1 Dehydrogenase HUT09_10625 ENOG4105CK5 oxidoreductase HUT09_10635 ENOG4105C03 ribonuclease HUT09_10660 ENOG4105CNI cell division protein FtsW HUT09_10680 ENOG4105DFF Rod shape-determining protein mreb HUT09_10685 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HUT09_10695 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HUT09_10700 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HUT09_10710 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HUT09_10715 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT09_10720 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT09_10725 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HUT09_10745 ENOG4108TGC Acyltransferase HUT09_10755 ENOG4107S91 Sodium hydrogen exchanger HUT09_10780 ENOG4105C85 amino acid HUT09_10790 ENOG4105C85 amino acid HUT09_10795 ENOG4105C85 amino acid HUT09_10805 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HUT09_10810 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HUT09_10815 ENOG4105CV1 Transketolase (EC 2.2.1.1) HUT09_10820 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HUT09_10825 ENOG41082BM Transcriptional regulator, arsr family HUT09_10835 ENOG4105EQK -acetyltransferase HUT09_10865 ENOG4105MC2 DSBA oxidoreductase HUT09_10880 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT09_10905 ENOG4105DUM transcriptional regulator, lysR family HUT09_10925 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 HUT09_10935 ENOG4105D8X mechanosensitive ion channel HUT09_10940 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HUT09_10950 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HUT09_10955 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUT09_10960 ENOG4105F8D glycoside hydrolase family 4 HUT09_10975 ENOG4105CT1 (ABC) transporter HUT09_11005 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT09_11010 ENOG4108Z18 K06886 hemoglobin HUT09_11035 ENOG4105VHU single-stranded DNA-binding protein HUT09_11080 ENOG4105CJ1 ABC, transporter HUT09_11095 ENOG4105C26 Dehydrogenase HUT09_11100 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HUT09_11105 ENOG4105DH8 myo-inositol catabolism HUT09_11115 ENOG4105D7K pfkb domain protein HUT09_11140 ENOG4107R13 MMPL domain protein HUT09_11165 ENOG4105C7H Helicase, RecD TraA family HUT09_11245 ENOG41060NJ transcriptional regulator HUT09_11265 ENOG4105F0K SARP family transcriptional regulator HUT09_11270 ENOG4105CJA serine threonine protein kinase HUT09_11300 ENOG4105F8J Adenylate Guanylate cyclase HUT09_11320 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUT09_11345 ENOG4105C7K acetolactate synthase HUT09_11355 ENOG4105CK7 Sodium proline symporter HUT09_11460 ENOG4105C29 acyl-CoA thioesterase HUT09_11470 ENOG4108XFF HUT09_11480 ENOG4105EXC Acyl-transferase HUT09_11510 ENOG4107QX3 carboxylase HUT09_11520 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HUT09_11525 ENOG4105C1G acyl-Coa dehydrogenase HUT09_11545 ENOG4105KVH Transcriptional regulator HUT09_11565 ENOG4105DY8 decarboxylase HUT09_11570 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HUT09_11580 ENOG4105DUU IucA IucC family protein HUT09_11600 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT09_11610 ENOG4105ECQ AraC Family Transcriptional Regulator HUT09_11615 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HUT09_11625 ENOG4108M1A Chitin-binding protein HUT09_11635 ENOG4105ETE Transcriptional regulator (LacI family HUT09_11645 ENOG4105DRS transport system, permease HUT09_11660 ENOG4105D0C transport protein HUT09_11665 ENOG4105D0C transport protein HUT09_11675 ENOG4108EUP Glycosyl hydrolase family 62 HUT09_11680 ENOG410804D Sensor Signal Transduction Histidine Kinase HUT09_11755 ENOG4105BZU Histidine kinase HUT09_11760 ENOG4105DEN Luciferase family HUT09_11770 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HUT09_11805 ENOG4105J5T Amp-dependent synthetase and ligase HUT09_11810 ENOG4108M1A Chitin-binding protein HUT09_11840 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT09_11870 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component HUT09_11880 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT09_11890 ENOG4105MWK D-amino acid dehydrogenase, small subunit HUT09_11895 ENOG41080U6 GntR family transcriptional regulator HUT09_11915 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HUT09_11920 ENOG4105D9R oxidoreductase HUT09_11925 ENOG41090KN UPF0303 protein HUT09_11935 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUT09_11945 ENOG4108U4N (sortase) family HUT09_12005 ENOG4105DUM transcriptional regulator, lysR family HUT09_12035 ENOG4105EGE secreted protein HUT09_12050 ENOG41081E8 Alpha beta hydrolase HUT09_12065 ENOG4108KTG Membrane protein, drug metabolite transporter HUT09_12070 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HUT09_12075 ENOG4105C0W non-ribosomal peptide synthetase HUT09_12085 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HUT09_12090 ENOG4106BRA Membrane HUT09_12120 ENOG4105BZ4 penicillin-binding protein HUT09_12125 ENOG4105KPY Small multidrug resistance protein HUT09_12145 ENOG4105CSH Transporter HUT09_12155 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HUT09_12165 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HUT09_12185 ENOG4108RQ5 Beta-lactamase domain-containing protein HUT09_12205 ENOG4105E0A ABC, transporter HUT09_12210 ENOG4105EHG Permease protein HUT09_12225 ENOG4105C85 amino acid HUT09_12235 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HUT09_12245 ENOG4108RWI nicotinamidase HUT09_12275 ENOG4105KF0 sporulation and cell division protein, SsgA HUT09_12280 ENOG4105CQB FAD linked oxidase domain protein HUT09_12290 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HUT09_12300 ENOG4105E90 ABC transporter HUT09_12305 ENOG4108IJ8 ABC transporter HUT09_12310 ENOG4105E90 ABC transporter HUT09_12315 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HUT09_12335 ENOG41063PX domain protein HUT09_12350 ENOG41086VY Fic/DOC family HUT09_12390 ENOG4105E2D ec 3.2.1.52 HUT09_12415 ENOG4108UJU UPF0301 protein HUT09_12420 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUT09_12435 ENOG4108426 dNA-binding protein HUT09_12445 ENOG4105EEM helicase HUT09_12445 ENOG4105EEM helicase HUT09_12470 ENOG4105DQQ Major facilitator superfamily MFS_1 HUT09_12490 ENOG4106NZI LysR family Transcriptional regulator HUT09_12500 ENOG4105KNA -acetyltransferase HUT09_12510 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HUT09_12515 ENOG4105CN1 protease HUT09_12520 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) HUT09_12525 ENOG4105CAK Cell division ATP-binding protein ftsE HUT09_12545 ENOG4108QVN serine threonine protein kinase HUT09_12550 ENOG4108UGD Serine Threonine protein kinase HUT09_12570 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HUT09_12575 ENOG4107SJB teichoic acid biosynthesis HUT09_12580 ENOG4105CG5 Glycosyl transferase (Group 1 HUT09_12585 ENOG4107SJB teichoic acid biosynthesis HUT09_12590 ENOG4107SJB teichoic acid biosynthesis HUT09_12600 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT09_12605 ENOG4107SJB teichoic acid biosynthesis HUT09_12610 ENOG4105K64 Glycosyl transferase, family 2 HUT09_12620 ENOG4108JGH Tetr family transcriptional regulator HUT09_12630 ENOG4105EY8 ABC transporter HUT09_12635 ENOG4105C7I Dehydrogenase HUT09_12660 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT09_12675 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_12680 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HUT09_12690 ENOG4105G3P Lipoprotein lpqB HUT09_12695 ENOG4105BZU Histidine kinase HUT09_12700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT09_12705 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HUT09_12720 ENOG4108WQ6 secreted protein HUT09_12725 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT09_12765 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HUT09_12775 ENOG4105EIP mannose-6-phosphate isomerase HUT09_12785 ENOG4105W49 UPF0434 protein HUT09_12790 ENOG4107QKV phosphomannomutase HUT09_12810 ENOG4107RGC Glycosyl transferase, family 2 HUT09_12815 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT09_12830 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HUT09_12840 ENOG4108S0S Nucleotidyl transferase HUT09_12855 ENOG4108KGH TRANSCRIPTIONal HUT09_12860 ENOG4107TB5 TRANSCRIPTIONal HUT09_12875 ENOG4108KGH TRANSCRIPTIONal HUT09_12885 ENOG4108KGH TRANSCRIPTIONal HUT09_12925 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUT09_12960 ENOG41065SU Two-component system sensor kinase HUT09_12965 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT09_12970 ENOG4105DUX Transporter HUT09_13000 ENOG41082AN stage II sporulation protein HUT09_13005 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_13010 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT09_13025 ENOG4105CGP Urocanate hydratase HUT09_13080 ENOG4105CHU acetyl-coa acetyltransferase HUT09_13105 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT09_13110 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT09_13115 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT09_13120 ENOG4105CEP NADH dehydrogenase HUT09_13140 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HUT09_13155 ENOG4106A3M Cytochrome p-450 HUT09_13175 ENOG4105D9P serine threonine protein kinase HUT09_13195 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HUT09_13270 ENOG4105CH2 amidohydrolase HUT09_13335 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT09_13340 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT09_13395 ENOG4106A3M Cytochrome p-450 HUT09_13425 ENOG4105ENE Histidine kinase HUT09_13440 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HUT09_13445 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HUT09_13450 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HUT09_13455 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HUT09_13465 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HUT09_13475 ENOG4108IG5 Transcriptional regulator HUT09_13490 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT09_13495 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HUT09_13500 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_13510 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HUT09_13555 ENOG4105C5H ABC transporter HUT09_13560 ENOG4105VTW prevent-host-death family HUT09_13565 ENOG4105KRQ Addiction module toxin, Txe YoeB family HUT09_13580 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HUT09_13590 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HUT09_13595 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUT09_13605 ENOG4105F8V Hydrolase, tatD family HUT09_13635 ENOG4108A04 Beta-lactamase HUT09_13685 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUT09_13730 ENOG4108JJB ABC transporter HUT09_13740 ENOG4105G01 cobalamin (vitamin B12) biosynthesis CbiM protein HUT09_13750 ENOG41067TZ transcriptional regulator, MarR family HUT09_13770 ENOG4105EYF MMPL domain protein HUT09_13800 ENOG4108BAS reductase HUT09_13810 ENOG4105F95 Monooxygenase HUT09_13820 ENOG4105CGK Exodeoxyribonuclease III HUT09_13825 ENOG4108Z7F N-acetyltransferase HUT09_13830 ENOG4105K4I Scp-like extracellular HUT09_13840 ENOG4106T9R serine protease HUT09_13860 ENOG4108RIR Molybdenum cofactor biosynthesis protein HUT09_13865 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT09_13875 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HUT09_13880 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HUT09_13890 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HUT09_13905 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HUT09_13915 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HUT09_13935 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HUT09_13940 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT09_13980 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HUT09_14005 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_14075 ENOG4105CHR reductase HUT09_14110 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUT09_14120 ENOG4105D8V Glucose sorbosone dehydrogenase HUT09_14125 ENOG4105CJN penicillin-binding protein HUT09_14185 ENOG4105CPC Aldo Keto reductase HUT09_14195 ENOG4108J20 pectate lyase HUT09_14200 ENOG4105WEM extracellular solute-binding protein HUT09_14235 ENOG4105DRR Transcriptional regulator, GntR family HUT09_14240 ENOG4105E9Z Nad-dependent epimerase dehydratase HUT09_14290 ENOG4105CHU acetyl-coa acetyltransferase HUT09_14295 ENOG4105CHR reductase HUT09_14310 ENOG4108R86 Transcriptional regulator HUT09_14340 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_14370 ENOG4105DVY radical SAM domain protein HUT09_14385 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HUT09_14395 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HUT09_14400 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HUT09_14410 ENOG4105C26 Dehydrogenase HUT09_14415 ENOG4105CRE cytochrome C HUT09_14420 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) HUT09_14425 ENOG4107QIV Cytochrome c biogenesis protein HUT09_14440 ENOG4105E93 esterase HUT09_14445 ENOG4108RH7 phosphoglycerate mutase HUT09_14450 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT09_14480 ENOG4105E2Y ABC, transporter HUT09_14495 ENOG4105E0Y RtcB Protein HUT09_14515 ENOG4105DK7 lysyl-tRNA synthetase HUT09_14520 ENOG4105C75 arginyL-tRNA synthetase HUT09_14530 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HUT09_14555 ENOG4105NAE bifunctional deaminase-reductase domain protein HUT09_14575 ENOG4105D52 delta-aminolevulinic acid dehydratase HUT09_14580 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUT09_14585 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HUT09_14590 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HUT09_14595 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HUT09_14640 ENOG4108XFF HUT09_14650 ENOG4106UW1 Major Facilitator superfamily HUT09_14655 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HUT09_14675 ENOG4105II7 pyrroline-5-carboxylate reductase HUT09_14685 ENOG4105CJ1 ABC, transporter HUT09_14695 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HUT09_14705 ENOG4105C01 Dihydroxy-acid dehydratase HUT09_14710 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HUT09_14715 ENOG4105EY0 Xylose isomerase domain protein TIM barrel HUT09_14720 ENOG4107R33 ppx gppa phosphatase HUT09_14725 ENOG4108JWX HUT09_14740 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HUT09_14750 ENOG4105CEN a g-specific adenine glycosylase HUT09_14755 ENOG4105NAF rna polymerase sigma factor HUT09_14760 ENOG41075QH Lipoprotein CseA HUT09_14765 ENOG4108PYU two-component system response regulator HUT09_14770 ENOG4108FKE two-component system sensor kinase HUT09_14775 ENOG4105DR5 peptidase HUT09_14825 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HUT09_14835 ENOG4108IYU L-aspartate oxidase HUT09_14840 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HUT09_14865 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_14880 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_14890 ENOG4108HQR Glycine betaine HUT09_14895 ENOG4105E90 ABC transporter HUT09_14900 ENOG4105E90 ABC transporter HUT09_14905 ENOG4108IJ8 ABC transporter HUT09_14915 ENOG4105CRK lysyL-tRNA synthetase HUT09_14935 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HUT09_14945 ENOG4105EUJ GTP cyclohydrolase i HUT09_14955 ENOG4108UGV hypoxanthine phosphoribosyltransferase HUT09_14960 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HUT09_14975 ENOG4105F0N pyrophosphate phospho-hydrolase HUT09_14985 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HUT09_14990 ENOG41082VC UPF0145 protein HUT09_14995 ENOG4105VCT ion-transport protein YfeO HUT09_15000 ENOG4105CS1 NAD(P)H quinone oxidoreductase HUT09_15005 ENOG4105CVK Glutamate decarboxylase HUT09_15025 ENOG4105C26 Dehydrogenase HUT09_15065 ENOG4105C2M dna polymerase I HUT09_15085 ENOG4106T9R serine protease HUT09_15095 ENOG4107T0D ABC, transporter HUT09_15120 ENOG4108ZJ4 polysaccharide deacetylase HUT09_15140 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT09_15145 ENOG4106N8J Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HUT09_15155 ENOG410829W Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HUT09_15195 ENOG4105C6E dna polymerase iii HUT09_15200 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HUT09_15205 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HUT09_15215 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT09_15225 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HUT09_15230 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HUT09_15235 ENOG4105WN5 stage II sporulation protein HUT09_15240 ENOG4108I5C dEAD DEAH box helicase HUT09_15335 ENOG4105C4R Atp-dependent dna helicase HUT09_15375 ENOG4107B2H carbonic anhydrase HUT09_15380 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT09_15385 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT09_15395 ENOG4105D74 hydrolase HUT09_15420 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HUT09_15455 ENOG4108JQC penicillin-binding protein 1A HUT09_15460 ENOG4105KTH gatB Yqey HUT09_15485 ENOG4108TCJ secreted hydrolase HUT09_15495 ENOG4105DR4 Methyltransferase HUT09_15515 ENOG4105NAF rna polymerase sigma factor HUT09_15525 ENOG4105CFH Aspartokinase HUT09_15555 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HUT09_15560 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HUT09_15575 ENOG4105DRR Transcriptional regulator, GntR family HUT09_15580 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT09_15585 ENOG4108V4B ThiJ pfpI HUT09_15595 ENOG4108762 serine threonine protein kinase HUT09_15600 ENOG4106UW1 Major Facilitator superfamily HUT09_15610 ENOG4108RFG Tetr family transcriptional regulator HUT09_15660 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUT09_15670 ENOG4105EMN RNA polymerase sigma factor HUT09_15695 ENOG4105CVA phosphate HUT09_15700 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUT09_15725 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_15745 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HUT09_15770 ENOG4105C87 Aminotransferase class I and II HUT09_15775 ENOG4107RCW fructose-bisphosphate aldolase HUT09_15780 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HUT09_15795 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HUT09_15820 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT09_15845 ENOG4105KNI merR family transcriptional Regulator HUT09_15850 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT09_15855 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HUT09_15860 ENOG4105CFG Acts as a chaperone (By similarity) HUT09_15865 ENOG4105D3Q Sugar transferase HUT09_15870 ENOG4105DF6 Fe-S oxidoreductase HUT09_15890 ENOG4105DHP deoxycytidine triphosphate deaminase HUT09_15935 ENOG4105DKQ ROK family HUT09_15950 ENOG4105CHR reductase HUT09_15955 ENOG4105CPQ Dehydrogenase HUT09_15960 ENOG4108KK4 3-dehydroquinate synthase HUT09_15965 ENOG4107QKV phosphomannomutase HUT09_15985 ENOG41065SU Two-component system sensor kinase HUT09_15990 ENOG4108KXV response regulator HUT09_16005 ENOG4105FF0 ErfK YbiS YcfS YnhG HUT09_16010 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUT09_16035 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT09_16055 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HUT09_16075 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HUT09_16085 ENOG4105EBR Carboxylesterase HUT09_16090 ENOG4105CAQ asparagine synthetase HUT09_16105 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT09_16125 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT09_16135 ENOG4108FKE two-component system sensor kinase HUT09_16140 ENOG4108PYU two-component system response regulator HUT09_16155 ENOG4105CHR reductase HUT09_16170 ENOG4105ETX regulatoR HUT09_16180 ENOG4107SDT Homocitrate synthase HUT09_16190 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HUT09_16195 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HUT09_16205 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT09_16210 ENOG4105D82 Glutamate dehydrogenase HUT09_16215 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT09_16255 ENOG4107S5I aldo keto reductase HUT09_16265 ENOG4105FKQ transcriptional regulator HUT09_16270 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HUT09_16295 ENOG4106P4H Cytochrome P450 HUT09_16300 ENOG4105DU1 integral membrane protein, terc HUT09_16315 ENOG4105X1Q TOBE domain protein HUT09_16330 ENOG4105KWG Pfam:DUF1696 HUT09_16340 ENOG4105CUB amino acid HUT09_16350 ENOG4107RWR Sodium hydrogen exchanger HUT09_16360 ENOG4105EYF MMPL domain protein HUT09_16365 ENOG4108TGC Acyltransferase HUT09_16380 ENOG4105C1J atp-dependent rna helicase HUT09_16385 ENOG4105VEQ Cold shock protein HUT09_16425 ENOG4105BZU Histidine kinase HUT09_16430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT09_16465 ENOG4108SZE gCN5-related N-acetyltransferase HUT09_16490 ENOG4105DZ6 Band 7 protein HUT09_16530 ENOG4105NCW Trka-c domain protein HUT09_16535 ENOG4107S91 Sodium hydrogen exchanger HUT09_16560 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT09_16570 ENOG4105C31 Tryptophanyl-tRNA synthetase HUT09_16580 ENOG4105EUZ Beta-lactamase domain protein HUT09_16585 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT09_16590 ENOG4108UZX fmn reductase HUT09_16645 ENOG4106F60 Histidine kinase HUT09_16650 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT09_16655 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HUT09_16665 ENOG4105C9M aspartyl-trna synthetase HUT09_16680 ENOG4105EUB pirin domain protein HUT09_16690 ENOG4105CSU acyl-Coa dehydrogenase HUT09_16700 ENOG4105DFM M18 family aminopeptidase HUT09_16725 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HUT09_16740 ENOG4108WYP Transcriptional regulator HUT09_16760 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HUT09_16765 ENOG4105CPP Dehydrogenase, E1 component HUT09_16795 ENOG4107QPV Serine Threonine protein kinase HUT09_16810 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT09_16820 ENOG4108VC7 Protein of unknown function (DUF2587) HUT09_16835 ENOG4105CVM Molybdenum cofactor synthesis domain protein HUT09_16840 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HUT09_16845 ENOG4107QSN dihydrolipoamide acetyltransferase HUT09_16865 ENOG4108IG5 Transcriptional regulator HUT09_16890 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HUT09_16895 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HUT09_16900 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HUT09_16905 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HUT09_16910 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT09_16920 ENOG41085GJ domain protein HUT09_16935 ENOG4105KVH Transcriptional regulator HUT09_16940 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUT09_16945 ENOG41064MX Tetr family transcriptional regulator HUT09_16955 ENOG4105TV9 FHA Domain-Containing protein HUT09_16960 ENOG4105HZM Fha domain containing protein HUT09_16975 ENOG4105CJN penicillin-binding protein HUT09_16985 ENOG4108RN7 integral membrane protein HUT09_16990 ENOG4108U4N (sortase) family HUT09_17005 ENOG4108U4N (sortase) family HUT09_17015 ENOG4105ZJT Cell division protein CrgA HUT09_17065 ENOG4108UGD Serine Threonine protein kinase HUT09_17095 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT09_17105 ENOG4105K7N UPF0232 protein HUT09_17110 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HUT09_17115 ENOG4108J5G 6-phosphogluconate dehydrogenase HUT09_17120 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUT09_17135 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HUT09_17140 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HUT09_17145 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUT09_17155 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HUT09_17160 ENOG4107QJE Chromosome Partitioning Protein HUT09_17175 ENOG4105K63 Thioredoxin HUT09_17180 ENOG4105C3M thioredoxin reductase HUT09_17195 ENOG4105D9P serine threonine protein kinase HUT09_17210 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HUT09_17230 ENOG4105BZ4 penicillin-binding protein HUT09_17255 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HUT09_17260 ENOG4107YH6 single-stranded DNA-binding protein HUT09_17265 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUT09_17270 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HUT09_17275 ENOG4107QI1 Mate efflux family protein HUT09_17280 ENOG4105CDU Replicative dna helicase HUT09_17295 ENOG4105ED2 Beta-lactamase HUT09_17300 ENOG410849A acetyltransferase, (GNAT) family HUT09_17305 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) HUT09_17310 ENOG4105F27 Major Facilitator HUT09_17330 ENOG4105C28 cystathionine HUT09_17335 ENOG41082T9 Membrane HUT09_17340 ENOG4106048 Cupin 2, conserved barrel domain protein HUT09_17365 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HUT09_17375 ENOG4105KAF membrAne HUT09_17385 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HUT09_17390 ENOG4107P2S Transcriptional regulator HUT09_17395 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT09_17400 ENOG4105C4M (Ubiquinol oxidase) subunit I HUT09_17405 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HUT09_17410 ENOG4108JJ9 ABC, transporter HUT09_17420 ENOG410667J hydrolase HUT09_17430 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) HUT09_17435 ENOG4107SWG transcriptional regulator MERR family HUT09_17450 ENOG4105DA5 (ABC) transporter HUT09_17475 ENOG410667J hydrolase HUT09_17480 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HUT09_17485 ENOG4105CQC Prephenate dehydratase HUT09_17490 ENOG4105DBE peroxidase HUT09_17495 ENOG4105JDN Copper resistance protein HUT09_17525 ENOG4107T6F Xaa-Pro aminopeptidase HUT09_17545 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT09_17585 ENOG4105X7H acyl-CoA dehydrogenase HUT09_17610 ENOG4105NAF rna polymerase sigma factor HUT09_17615 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_17645 ENOG4108KPJ rna polymerase sigma factor HUT09_17665 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT09_17670 ENOG4105BZU Histidine kinase HUT09_17680 ENOG4105EDW glycosyl transferase, family 39 HUT09_17695 ENOG4105C57 major facilitator superfamily HUT09_17710 ENOG410905P Pyridoxamine 5-phosphate HUT09_17715 ENOG4108YYC ycei family HUT09_17725 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HUT09_17740 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_17745 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_17750 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein HUT09_17765 ENOG4108Z6B deaminase HUT09_17780 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HUT09_17810 ENOG4105CHP RNA polymerase HUT09_17820 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase HUT09_17870 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUT09_17875 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HUT09_17890 ENOG41081F0 Precorrin-8x methylmutase HUT09_17900 ENOG4105CTK cobaltochelatase, cobn subunit HUT09_17975 ENOG4105GFG DUF218 domain HUT09_18030 ENOG4107ZVI PhiRv2 prophage protein HUT09_18040 ENOG4107T65 Integrase HUT09_18060 ENOG4105C12 Phosphoribosylglycinamide synthetase HUT09_18075 ENOG4105C8V SAICAR synthetase HUT09_18085 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_18120 ENOG410839H phosphoribosylformylglycinamidine synthase HUT09_18125 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HUT09_18130 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HUT09_18140 ENOG4105E4C Lytic transglycosylase catalytic HUT09_18160 ENOG4105CXB phosphoribosylaminoimidazole synthetase HUT09_18195 ENOG4105CQ7 ATP-dependent helicase HUT09_18205 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT09_18210 ENOG4107QIV Cytochrome c biogenesis protein HUT09_18240 ENOG41083YR Protein CrcB homolog HUT09_18245 ENOG41083TI Protein CrcB homolog HUT09_18255 ENOG4105C1J atp-dependent rna helicase HUT09_18265 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUT09_18275 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUT09_18290 ENOG4107TXC Transcriptional regulator HUT09_18300 ENOG4105E4C Lytic transglycosylase catalytic HUT09_18305 ENOG4105CPC Aldo Keto reductase HUT09_18315 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HUT09_18320 ENOG4105D5U fad dependent oxidoreductase HUT09_18380 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_18385 ENOG4105BZU Histidine kinase HUT09_18395 ENOG4105CJ1 ABC, transporter HUT09_18460 ENOG4105E4C Lytic transglycosylase catalytic HUT09_18465 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HUT09_18480 ENOG4105VPX protein, conserved in bacteria HUT09_18490 ENOG4105CJ3 phosphate transporter HUT09_18495 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUT09_18510 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HUT09_18525 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HUT09_18535 ENOG4105E2Y ABC, transporter HUT09_18540 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HUT09_18550 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT09_18560 ENOG4105CGH 5'-nucleotidase HUT09_18575 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT09_18610 ENOG4105C57 major facilitator superfamily HUT09_18655 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C HUT09_18675 ENOG4105C0H protease HUT09_18685 ENOG4105ETE Transcriptional regulator (LacI family HUT09_18690 ENOG4107NHD transcriptional regulator HUT09_18715 ENOG4105KHC sulfurtransferase HUT09_18720 ENOG4105PKJ carbohydrate binding HUT09_18750 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HUT09_18755 ENOG41090R7 Ferric uptake HUT09_18760 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HUT09_18765 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HUT09_18780 ENOG4105HHS UPF0256 protein HUT09_18845 ENOG4105RV9 Transcriptional regulator HUT09_18860 ENOG4108JIK carboxylase HUT09_18885 ENOG4105CZS beta-ketoacyl synthase HUT09_18915 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HUT09_18920 ENOG4105D8K carboxyl transferase HUT09_18955 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT09_18965 ENOG4105KVH Transcriptional regulator HUT09_19015 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT09_19020 ENOG4108YZJ Pfam:DUF2596 HUT09_19120 ENOG4105CMD Transcriptional regulator, GntR family HUT09_19165 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUT09_19175 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT09_19195 ENOG4105BZU Histidine kinase HUT09_19210 ENOG4108VJ1 Transcriptional regulator (CarD family HUT09_19215 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HUT09_19220 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HUT09_19230 ENOG4105C8N cysteinyl-tRNA synthetase HUT09_19235 ENOG4105C2N RNA methyltransferase TrmH family group 3 HUT09_19245 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HUT09_19270 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein HUT09_19275 ENOG4107S9F NmrA family HUT09_19295 ENOG4105CJP fad dependent oxidoreductase HUT09_19315 ENOG4107S11 squalene-associated FAD-dependent desaturase HUT09_19335 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_19340 ENOG4105ENE Histidine kinase HUT09_19350 ENOG4107SNB ankyrin repeat protein YahD HUT09_19375 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HUT09_19385 ENOG4105BZU Histidine kinase HUT09_19400 ENOG4105CE4 GlcNAc 6-P deacetylase HUT09_19425 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HUT09_19430 ENOG4105C3Q Glycosyl transferase, family 2 HUT09_19490 ENOG4105EMN RNA polymerase sigma factor HUT09_19515 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HUT09_19535 ENOG4105ETE Transcriptional regulator (LacI family HUT09_19565 ENOG4105BZU Histidine kinase HUT09_19570 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUT09_19600 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HUT09_19605 ENOG4106G6Q Transcriptional regulator HUT09_19645 ENOG4105E7W lamb ycsf family protein HUT09_19665 ENOG4106N3A copper homeostasis protein cutc HUT09_19670 ENOG4105EEM helicase HUT09_19680 ENOG4105CFI type iii restriction protein res subunit HUT09_19695 ENOG4107T6F Xaa-Pro aminopeptidase HUT09_19700 ENOG4105KXC Collagenase HUT09_19745 ENOG4108MES Periplasmic binding protein HUT09_19750 ENOG4105E0A ABC, transporter HUT09_19755 ENOG4105TVJ transport system, permease HUT09_19760 ENOG4105DQ5 transport system permease protein HUT09_19780 ENOG4105VEQ Cold shock protein HUT09_19785 ENOG4105E63 Pfam:DUF178 HUT09_19790 ENOG4108UIH futalosine nucleosidase HUT09_19800 ENOG4108N0W Major Facilitator superfamily HUT09_19830 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HUT09_19840 ENOG4105C7N Xanthine uracil vitamin C permease HUT09_19850 ENOG4105XMC MarR family Transcriptional regulator HUT09_19860 ENOG4105CPC Aldo Keto reductase HUT09_19880 ENOG4107TPY serine threonine protein kinase HUT09_19890 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HUT09_19895 ENOG4108M0I Transcriptional regulator HUT09_19915 ENOG4108KPJ rna polymerase sigma factor HUT09_19975 ENOG41067SE Tetr family transcriptional regulator HUT09_19980 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUT09_19985 ENOG4108KTG Membrane protein, drug metabolite transporter HUT09_19995 ENOG4108Z6Z Transcriptional regulator HUT09_20000 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT09_20050 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT09_20070 ENOG4105CHJ isochorismatase hydrolase HUT09_20110 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HUT09_20140 ENOG4108TQ9 Histidine kinase HUT09_20145 ENOG4105CQB FAD linked oxidase domain protein HUT09_20155 ENOG4106NZI LysR family Transcriptional regulator HUT09_20165 ENOG41090G8 Toxic component of a toxin-antitoxin (TA) module. A HUT09_20175 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HUT09_20190 ENOG4107QX3 carboxylase HUT09_20205 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_20210 ENOG41060WC Enoyl-CoA hydratase HUT09_20240 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT09_20250 ENOG4108BQ6 cytochrome p450 HUT09_20275 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HUT09_20285 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT09_20290 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT09_20305 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT09_20310 ENOG4106F60 Histidine kinase HUT09_20315 ENOG4108SU4 UPF0309 protein HUT09_20325 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HUT09_20340 ENOG4105CJ1 ABC, transporter HUT09_20385 ENOG41082AN stage II sporulation protein HUT09_20390 ENOG4107EG8 signal transduction protein with EFhand domain HUT09_20395 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_20405 ENOG4105CC9 acyl-Coa dehydrogenase HUT09_20410 ENOG4105D2B acyl-CoA dehydrogenase HUT09_20425 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HUT09_20430 ENOG4105CC9 acyl-Coa dehydrogenase HUT09_20475 ENOG4105D2S major facilitator superfamily HUT09_20480 ENOG4105MXW flavin reductase domain protein, FMN-binding HUT09_20490 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HUT09_20510 ENOG4105CGU Enoyl-CoA hydratase HUT09_20535 ENOG4108JQ1 Dehydrogenase HUT09_20545 ENOG4107S9F NmrA family HUT09_20550 ENOG4105IIU Aminopeptidase HUT09_20560 ENOG4105H3G oxidoreductase HUT09_20565 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HUT09_20570 ENOG4105DQ5 transport system permease protein HUT09_20575 ENOG4105TVJ transport system, permease HUT09_20595 ENOG4105D0M Protease HtpX homolog HUT09_20600 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HUT09_20610 ENOG4105D2B acyl-CoA dehydrogenase HUT09_20620 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HUT09_20645 ENOG4105E39 Enoyl-CoA hydratase HUT09_20660 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_20670 ENOG4105F0K SARP family transcriptional regulator HUT09_20685 ENOG4105VEQ Cold shock protein HUT09_20690 ENOG4105EV6 Pfam:DUF178 HUT09_20700 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUT09_20725 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT09_20730 ENOG4106FTQ Taurine ABC transporter, periplasmic HUT09_20745 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT09_20790 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_20795 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT09_20800 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_20810 ENOG4107QIZ NADH dehydrogenase HUT09_20815 ENOG4108IEH NADH dehydrogenase subunit g HUT09_20820 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT09_20825 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_20830 ENOG41087XN oxidoreductase HUT09_20835 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_20840 ENOG4105D65 subunit l HUT09_20850 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_20855 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT09_20865 ENOG4105ERH Fumarylacetoacetate hydrolase HUT09_20875 ENOG4105DUX Transporter HUT09_20890 ENOG4105CJ1 ABC, transporter HUT09_20920 ENOG4105DQF Hydrolase HUT09_20925 ENOG4106T9R serine protease HUT09_20960 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HUT09_20990 ENOG4105ECR NmrA family HUT09_20995 ENOG4105KVH Transcriptional regulator HUT09_21000 ENOG4105DQU oxidoreductase, subunit beta HUT09_21005 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HUT09_21025 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT09_21030 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_21035 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT09_21040 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT09_21045 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_21050 ENOG4107YX3 NADH dehydrogenase subunit j HUT09_21055 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_21060 ENOG4105D65 subunit l HUT09_21065 ENOG4105C8S subunit m HUT09_21070 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_21075 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HUT09_21080 ENOG4105D0M Protease HtpX homolog HUT09_21085 ENOG410901E Membrane HUT09_21100 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT09_21105 ENOG4108VPT UPF0234 protein HUT09_21135 ENOG4105WDJ 50S ribosomal protein L33 HUT09_21140 ENOG410900P UPF0336 protein HUT09_21150 ENOG4107R4N Cell wall formation (By similarity) HUT09_21180 ENOG410683Z Preprotein translocase SecE subunit HUT09_21185 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HUT09_21190 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HUT09_21195 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HUT09_21205 ENOG4108VZM 50s ribosomal protein L10 HUT09_21215 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT09_21220 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT09_21325 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HUT09_21330 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HUT09_21335 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HUT09_21360 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HUT09_21365 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HUT09_21370 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HUT09_21375 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HUT09_21380 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HUT09_21385 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HUT09_21390 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HUT09_21395 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HUT09_21400 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HUT09_21405 ENOG41082SA 50s ribosomal protein l29 HUT09_21410 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HUT09_21415 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HUT09_21420 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HUT09_21425 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HUT09_21430 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUT09_21435 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HUT09_21440 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HUT09_21445 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HUT09_21450 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HUT09_21455 ENOG410849U 50S ribosomal protein L30 HUT09_21460 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HUT09_21465 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HUT09_21470 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HUT09_21480 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HUT09_21490 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HUT09_21495 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HUT09_21500 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT09_21505 ENOG4108ZT0 50S ribosomal protein l17 HUT09_21510 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HUT09_21525 ENOG4105C5H ABC transporter HUT09_21530 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HUT09_21535 ENOG4108UJD 30S ribosomal protein S9 HUT09_21540 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HUT09_21550 ENOG4105CS9 pantothenic acid kinase HUT09_21555 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT09_21570 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT09_21580 ENOG4105GRZ Ycii-related protein HUT09_21585 ENOG4105CHP RNA polymerase HUT09_21605 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT09_21610 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HUT09_21620 ENOG4105K78 MarR family Transcriptional regulator HUT09_21625 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HUT09_21630 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HUT09_21635 ENOG4108097 ATP-binding protein HUT09_21660 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUT09_21710 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HUT09_21725 ENOG4105DRS transport system, permease HUT09_21730 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HUT09_21745 ENOG4105EMU Dehydrogenase HUT09_21755 ENOG4105DND Transcriptional regulator HUT09_21760 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT09_21770 ENOG4108MMM RNA Polymerase HUT09_21780 ENOG4107QVP Dehydrogenase HUT09_21790 ENOG4107QQG Dehydrogenase HUT09_21810 ENOG4107TPY serine threonine protein kinase HUT09_21815 ENOG4105C26 Dehydrogenase HUT09_21835 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT09_21865 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_21875 ENOG4105K4H Nlp p60 protein HUT09_21915 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HUT09_21920 ENOG4105RD5 HUT09_21925 ENOG4105DEG Vwa containing coxe family protein HUT09_21930 ENOG4105CMV Succinyl-CoA synthetase subunit beta HUT09_21960 ENOG4105DC1 bifunctional purine biosynthesis protein purh HUT09_21975 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HUT09_21990 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HUT09_22010 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT09_22015 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT09_22030 ENOG4106032 Glutathionylspermidine synthase HUT09_22035 ENOG4105C8Y Acetylornithine aminotransferase HUT09_22040 ENOG4105C31 Tryptophanyl-tRNA synthetase HUT09_22060 ENOG4107H3J ribonuclease HUT09_22070 ENOG4107RN3 metallophosphoesterase HUT09_22080 ENOG4108RZE Tetr family transcriptional regulator HUT09_22110 ENOG4108J01 L-aspartate oxidase HUT09_22130 ENOG4105E2D ec 3.2.1.52 HUT09_22210 ENOG4105F0K SARP family transcriptional regulator HUT09_22220 ENOG4105F0K SARP family transcriptional regulator HUT09_22230 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUT09_22245 ENOG4108MMM RNA Polymerase HUT09_22260 ENOG4108NIW Leucine export protein LeuE HUT09_22285 ENOG4108478 ec 3.2.1.18 HUT09_22300 ENOG4105K64 Glycosyl transferase, family 2 HUT09_22310 ENOG4105F0R Cytidylyltransferase HUT09_22325 ENOG4107RM1 amidohydrolase HUT09_22330 ENOG4105DIH basic membrane HUT09_22335 ENOG4108JQ9 ABC transporter HUT09_22340 ENOG4105UIB (ABC) transporter HUT09_22385 ENOG4105D94 Major Facilitator Superfamily HUT09_22390 ENOG4107RSM transcriptional regulator HUT09_22400 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT09_22425 ENOG41065SU Two-component system sensor kinase HUT09_22430 ENOG4108KXV response regulator HUT09_22435 ENOG4105NAF rna polymerase sigma factor HUT09_22465 ENOG4105C26 Dehydrogenase HUT09_22470 ENOG4105C26 Dehydrogenase HUT09_22485 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HUT09_22515 ENOG4108JIK carboxylase HUT09_22525 ENOG4107WR6 Maf-like protein HUT09_22535 ENOG4105D8K carboxyl transferase HUT09_22545 ENOG4108QER Adenylate cyclase HUT09_22550 ENOG4105E39 Enoyl-CoA hydratase HUT09_22555 ENOG4105KDM Diguanylate cyclase with gaf sensor HUT09_22560 ENOG4105C84 Histidine ammonia-lyase HUT09_22575 ENOG4105FF0 ErfK YbiS YcfS YnhG HUT09_22595 ENOG4107R37 Glutamate dehydrogenase HUT09_22620 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HUT09_22645 ENOG4105NAF rna polymerase sigma factor HUT09_22655 ENOG4105BZU Histidine kinase HUT09_22665 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HUT09_22670 ENOG4105FUA antagonist HUT09_22675 ENOG4107MMM Anti-sigma-factor antagonist HUT09_22680 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT09_22685 ENOG4105C7B Threonine dehydratase HUT09_22700 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HUT09_22710 ENOG4105T1M mycothiol conjugate amidase mca HUT09_22730 ENOG4105C7Z Conserved Protein HUT09_22740 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HUT09_22785 ENOG4105KVH Transcriptional regulator HUT09_22820 ENOG4108FUF Transcriptional regulator, IclR family HUT09_22825 ENOG4105KME endoribonuclease L-psp HUT09_22830 ENOG4105C6Z Gluconate HUT09_22895 ENOG4105RAK Histidine kinase HUT09_22900 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_22920 ENOG4107QKZ Ompa motb domain protein HUT09_22980 ENOG4105CPC Aldo Keto reductase HUT09_22985 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUT09_22990 ENOG4108IAB Phoh family HUT09_23005 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT09_23010 ENOG4105D3R alkyl hydroperoxide reductase HUT09_23025 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT09_23045 ENOG4105BZ4 penicillin-binding protein HUT09_23060 ENOG4105C9Q fumarate hydratase class II HUT09_23070 ENOG4105DFM M18 family aminopeptidase HUT09_23075 ENOG4107GFK fumarate HUT09_23100 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HUT09_23110 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUT09_23120 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HUT09_23135 ENOG4105C3G gtp-binding protein HUT09_23195 ENOG4108Z6Z Transcriptional regulator HUT09_23240 ENOG41087YS Phage shock protein A HUT09_23250 ENOG4105CKK Glycosyl transferase, family 2 HUT09_23260 ENOG4105CHP RNA polymerase HUT09_23265 ENOG4105GRZ Ycii-related protein HUT09_23375 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HUT09_23405 ENOG4105DRS transport system, permease HUT09_23410 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT09_23425 ENOG4105KA0 thioesterase Superfamily protein HUT09_23430 ENOG4105ETE Transcriptional regulator (LacI family HUT09_23440 ENOG4105CI3 gtp-binding protein typa HUT09_23450 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT09_23455 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_23460 ENOG4105C3U ABC transporter HUT09_23465 ENOG4108JQ7 (ABC) transporter HUT09_23475 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT09_23480 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_23485 ENOG4105C3U ABC transporter HUT09_23490 ENOG4108JQ7 (ABC) transporter HUT09_23505 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUT09_23520 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HUT09_23525 ENOG4105EGE secreted protein HUT09_23535 ENOG4108UW5 maltose o-acetyltransferase HUT09_23550 ENOG4105CJA serine threonine protein kinase HUT09_23575 ENOG41063JG Transcriptional regulator HUT09_23585 ENOG4108Z4U Ferredoxin HUT09_23605 ENOG4107R4C succinyl-diaminopimelate desuccinylase HUT09_23610 ENOG4108URH decarboxylase HUT09_23615 ENOG4105EEI dihydropteroate synthase HUT09_23625 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT09_23630 ENOG4105CGU Enoyl-CoA hydratase HUT09_23645 ENOG4105DU6 RNA polymerase HUT09_23660 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HUT09_23695 ENOG4105D7N magnesium and cobalt transport protein CorA HUT09_23705 ENOG4105DXB Major Facilitator superfamily HUT09_23715 ENOG4105DB7 PHP domain protein HUT09_23720 ENOG41081FY multiple antibiotic resistance (MarC)-related HUT09_23740 ENOG4105C1J atp-dependent rna helicase HUT09_23780 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT09_23785 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_23790 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT09_23850 ENOG4105C4R Atp-dependent dna helicase HUT09_23855 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT09_23880 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT09_23895 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HUT09_23950 ENOG41063PX domain protein HUT09_23960 ENOG4105DJZ UPF0182 protein HUT09_23995 ENOG4107TK4 histidinol-phosphate phosphatase HUT09_24010 ENOG4105KPY Small multidrug resistance protein HUT09_24015 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUT09_24020 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUT09_24030 ENOG4108RAV Conserved protein HUT09_24040 ENOG4105EMN RNA polymerase sigma factor HUT09_24045 ENOG4105WMN AntiSigma factor HUT09_24050 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUT09_24065 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT09_24095 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT09_24100 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT09_24110 ENOG4105D22 carbon starvation protein HUT09_24115 ENOG4105FDP GntR family transcriptional regulator HUT09_24135 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUT09_24140 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HUT09_24145 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT09_24160 ENOG4105CBD Diacylglycerol kinase HUT09_24175 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HUT09_24200 ENOG41081JD Transcriptional regulator HUT09_24205 ENOG4105ESN nucleotide-binding protein HUT09_24230 ENOG4107SQD Transcriptional regulator, GntR family HUT09_24265 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_24270 ENOG4105BZU Histidine kinase HUT09_24290 ENOG4108VEQ Superoxide dismutase HUT09_24305 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT09_24310 ENOG4105NAF rna polymerase sigma factor HUT09_24320 ENOG4105CDA abc transporter atp-binding protein HUT09_24325 ENOG4105E5Q amino acid AbC transporter HUT09_24330 ENOG4105EAB amino acid AbC transporter HUT09_24335 ENOG4105C6K Malic enzyme HUT09_24340 ENOG4105CB2 alcohol dehydrogenase HUT09_24345 ENOG4105C4C beta-galactosidase HUT09_24360 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT09_24385 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HUT09_24390 ENOG4105EB3 Histidine kinase HUT09_24395 ENOG4108PYU two-component system response regulator HUT09_24415 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HUT09_24420 ENOG4108ZJ4 polysaccharide deacetylase HUT09_24425 ENOG4105XMC MarR family Transcriptional regulator HUT09_24435 ENOG4105BZU Histidine kinase HUT09_24460 ENOG4105ZXU NLP P60 protein HUT09_24475 ENOG41060BG Tetr family transcriptional regulator HUT09_24510 ENOG4105CJN penicillin-binding protein HUT09_24525 ENOG4108FKE two-component system sensor kinase HUT09_24545 ENOG4105DQE DNA ligase HUT09_24550 ENOG4105FDF Could be involved in DNA repair (By similarity) HUT09_24595 ENOG4105C75 arginyL-tRNA synthetase HUT09_24600 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT09_24605 ENOG4105D6E homoserine dehydrogenase HUT09_24610 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUT09_24615 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HUT09_24625 ENOG4108KGH TRANSCRIPTIONal HUT09_24630 ENOG4105VFB Binds the 23S rRNA (By similarity) HUT09_24635 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HUT09_24640 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT09_24650 ENOG4107ZF2 Phosphatase HUT09_24665 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT09_24675 ENOG4105Z3P ATP synthase HUT09_24685 ENOG4105ZA1 atp synthase HUT09_24690 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HUT09_24695 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HUT09_24700 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HUT09_24705 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HUT09_24710 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HUT09_24715 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HUT09_24735 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_24745 ENOG4105IIP Membrane HUT09_24755 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT09_24770 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HUT09_24825 ENOG4105CHU acetyl-coa acetyltransferase HUT09_24850 ENOG4105ETX regulatoR HUT09_24855 ENOG4105BZU Histidine kinase HUT09_24900 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT09_24920 ENOG4105WX6 Membrane HUT09_24930 ENOG4106R7G Glycoside hydrolase family 5 HUT09_24965 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HUT09_24970 ENOG4105C6K Malic enzyme HUT09_24975 ENOG4105CTQ phosphohexokinase HUT09_24985 ENOG4108MRH transcriptional regulatory protein HUT09_24990 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HUT09_24995 ENOG4105CK2 sodium dicarboxylate symporter HUT09_25005 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HUT09_25010 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HUT09_25015 ENOG4105CG3 alpha amylase, catalytic region HUT09_25020 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HUT09_25025 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HUT09_25060 ENOG4105BZ1 (ABC) transporter HUT09_25065 ENOG4105BZ1 (ABC) transporter HUT09_25070 ENOG4105CJ1 ABC, transporter HUT09_25085 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_25130 ENOG4105EBR Carboxylesterase HUT09_25170 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HUT09_25180 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUT09_25185 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUT09_25215 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HUT09_25230 ENOG4105C57 major facilitator superfamily HUT09_25240 ENOG4105CHR reductase HUT09_25375 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HUT09_25425 ENOG4105BZW Glycerate kinase HUT09_25435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT09_25440 ENOG4106F60 Histidine kinase HUT09_25480 ENOG4105EJQ L-serine dehydratase HUT09_25485 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT09_25490 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HUT09_25495 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HUT09_25515 ENOG4108J59 Extracellular solute-binding protein, family 5 HUT09_25520 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT09_25525 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_25530 ENOG4105C3U ABC transporter HUT09_25535 ENOG4108JQ7 (ABC) transporter HUT09_25540 ENOG4105EN6 Membrane HUT09_25575 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HUT09_25595 ENOG4105EMU Dehydrogenase HUT09_25605 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUT09_25610 ENOG4105BZU Histidine kinase HUT09_25615 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT09_25620 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT09_25630 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT09_25635 ENOG4107R5R arsenical pump membrane protein HUT09_25640 ENOG4105HSS phospholipase C HUT09_25645 ENOG4105EYF MMPL domain protein HUT09_25670 ENOG4108FN7 Aldo keto reductase HUT09_25680 ENOG4105BZU Histidine kinase HUT09_25690 ENOG4108ZP8 Acetolactate synthase small subunit HUT09_25695 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HUT09_25700 ENOG4108JQ1 Dehydrogenase HUT09_25725 ENOG4107YHD transcriptional regulator HUT09_25735 ENOG4105C26 Dehydrogenase HUT09_25740 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HUT09_25755 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT09_25760 ENOG41080UQ Transcriptional regulator HUT09_25765 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HUT09_25770 ENOG4105CM2 brancheD-chain amino acid aminotransferase HUT09_25805 ENOG4105DWY Agmatine deiminase HUT09_25815 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT09_25820 ENOG4105ETE Transcriptional regulator (LacI family HUT09_25840 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_25845 ENOG4105C3U ABC transporter HUT09_25875 ENOG41086D8 Transcriptional regulator HUT09_25900 ENOG4105C3M thioredoxin reductase HUT09_25910 ENOG4107WMG L,D-carboxypeptidase HUT09_25925 ENOG4105KVH Transcriptional regulator HUT09_25940 ENOG4105CH6 catalase HUT09_25950 ENOG4105DQ5 transport system permease protein HUT09_25955 ENOG4105TVJ transport system, permease HUT09_25960 ENOG4105E0A ABC, transporter HUT09_25995 ENOG4105ESP cell wall surface anchor family protein HUT09_26000 ENOG4105D8K carboxyl transferase HUT09_26020 ENOG4105GWZ Roadblock lc7 family protein HUT09_26040 ENOG4105GWZ Roadblock lc7 family protein HUT09_26055 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HUT09_26060 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HUT09_26095 ENOG41069M3 Transcriptional regulator HUT09_26100 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT09_26105 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT09_26115 ENOG4105K70 DNA-binding protein HUT09_26135 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HUT09_26140 ENOG4105CPF Cell wall formation (By similarity) HUT09_26155 ENOG4105DWF phosphomethylpyrimidine kinase HUT09_26160 ENOG4105VB9 50S ribosomal protein l28 HUT09_26165 ENOG4105DP4 dak2 domain fusion protein ylov HUT09_26170 ENOG4105CB5 ATP-dependent DNA helicase recG HUT09_26175 ENOG4106H78 methyltransferase HUT09_26180 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HUT09_26195 ENOG41084BZ 50S ribosomal protein L32 HUT09_26200 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HUT09_26205 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HUT09_26210 ENOG4105KVH Transcriptional regulator HUT09_26215 ENOG4105K4I Scp-like extracellular HUT09_26220 ENOG4108375 Acylphosphatase (EC 3.6.1.7) HUT09_26230 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HUT09_26270 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HUT09_26290 ENOG4105K5M 30s ribosomal protein S16 HUT09_26295 ENOG41082KU UPF0109 protein HUT09_26300 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HUT09_26305 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HUT09_26310 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HUT09_26325 ENOG4107QYR Signal peptidase i HUT09_26330 ENOG4107QYR Signal peptidase i HUT09_26345 ENOG41080R2 UPF0102 protein HUT09_26360 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_26375 ENOG4105CE9 30S ribosomal protein S2 HUT09_26380 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HUT09_26385 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HUT09_26390 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HUT09_26400 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HUT09_26410 ENOG4108I5D sulfate abc transporter HUT09_26430 ENOG4105C19 ABC transporter HUT09_26435 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT09_26445 ENOG4105C26 Dehydrogenase HUT09_26465 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HUT09_26470 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT09_26490 ENOG4107RUE extracellular solute-binding protein family 1 HUT09_26495 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT09_26500 ENOG4105F38 ABC transporter, permease HUT09_26505 ENOG4105D38 putrescine abc transporter HUT09_26510 ENOG4105CJP fad dependent oxidoreductase HUT09_26540 ENOG4105G9B Transcriptional regulator HUT09_26545 ENOG4105C26 Dehydrogenase HUT09_26555 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HUT09_26560 ENOG4105DZP Membrane-associated zinc metalloprotease HUT09_26565 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUT09_26580 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUT09_26600 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HUT09_26625 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HUT09_26630 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HUT09_26665 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_26670 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT09_26675 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HUT09_26700 ENOG4108T50 Protein of unknown function (DUF690) HUT09_26735 ENOG4105EC2 ftsk spoIIIe HUT09_26745 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HUT09_26750 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HUT09_26755 ENOG4105C1V Peptidase, M16 HUT09_26760 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HUT09_26785 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT09_26790 ENOG4105CN5 Metallo-Beta-Lactamase HUT09_26820 ENOG4105BZU Histidine kinase HUT09_26825 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUT09_26830 ENOG4107QZI cell division protein FtsK HUT09_26840 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HUT09_26850 ENOG4105CEV competence damage-inducible protein HUT09_26855 ENOG4105WBV Transcriptional regulator HUT09_26860 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HUT09_26870 ENOG4105CHR reductase HUT09_26875 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HUT09_26880 ENOG4107QRT dEAD DEAH box helicase HUT09_26885 ENOG4106AXJ AraC family transcriptional regulator HUT09_26915 ENOG4105CHR reductase HUT09_26920 ENOG4107SM8 Adenylate Guanylate cyclase HUT09_26925 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT09_26930 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HUT09_26960 ENOG4105DRP amino acid AbC transporter HUT09_26965 ENOG4105EAD ABC transporter HUT09_26970 ENOG4107UBR Extracellular solute-binding protein family 3 HUT09_26975 ENOG4105CDA abc transporter atp-binding protein HUT09_26980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT09_26985 ENOG4105EB3 Histidine kinase HUT09_26990 ENOG4105H1G trap transporter solute receptor taxi family HUT09_26995 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HUT09_27010 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HUT09_27020 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HUT09_27025 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUT09_27035 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HUT09_27075 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUT09_27080 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HUT09_27085 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT09_27090 ENOG4108N5B 2-phosphosulfolactate phosphatase HUT09_27120 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT09_27135 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT09_27150 ENOG4105D5T phosphonate abc transporter HUT09_27155 ENOG4105C6F GntR Family Transcriptional Regulator HUT09_27160 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_27185 ENOG4107QN1 sodium solute HUT09_27190 ENOG4108MRH transcriptional regulatory protein HUT09_27195 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HUT09_27205 ENOG4105BZN citrate synthase HUT09_27210 ENOG4105BZN citrate synthase HUT09_27220 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT09_27240 ENOG4105DRR Transcriptional regulator, GntR family HUT09_27245 ENOG410849S phosphocarrier protein (HPr) HUT09_27250 ENOG4105CD5 CoA-binding domain protein HUT09_27265 ENOG4107W53 thymidine kinase HUT09_27300 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HUT09_27315 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT09_27320 ENOG4106F60 Histidine kinase HUT09_27345 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HUT09_27395 ENOG4107VEG TrkA-N domain protein HUT09_27400 ENOG4105C0X amino acid HUT09_27405 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUT09_27490 ENOG4106F1P AAA ATPase, central domain protein HUT09_27500 ENOG4105EC2 ftsk spoIIIe HUT09_27560 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT09_27565 ENOG4108IG5 Transcriptional regulator HUT09_27575 ENOG4105M4P Tetr family transcriptional regulator HUT09_27580 ENOG4105F27 Major Facilitator HUT09_27590 ENOG4105KHN chorismate mutase HUT09_27595 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HUT09_27605 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HUT09_27610 ENOG4105HHS UPF0256 protein HUT09_27645 ENOG4108IG5 Transcriptional regulator HUT09_27695 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HUT09_27700 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HUT09_27705 ENOG4105N14 lysine exporter protein LysE YggA HUT09_27710 ENOG4107SQD Transcriptional regulator, GntR family HUT09_27720 ENOG4107MM9 BNR Asp-box repeat-containing protein HUT09_27765 ENOG4105DQ5 transport system permease protein HUT09_27770 ENOG4105TVJ transport system, permease HUT09_27800 ENOG4107T5V SNARE associated Golgi HUT09_27810 ENOG4105E98 transcriptional regulator DeoR family HUT09_27835 ENOG4107QK5 Homocysteine s-methyltransferase HUT09_27845 ENOG4107S1Q Phosphatase HUT09_27850 ENOG4105CEU Arginine dihydrolase HUT09_27855 ENOG4105DBV ornithine carbamoyltransferase HUT09_27860 ENOG4105CUB amino acid HUT09_27870 ENOG4105CGU Enoyl-CoA hydratase HUT09_27905 ENOG4105VR1 Pfam:DUF1271 HUT09_27910 ENOG4105D65 subunit l HUT09_27915 ENOG4105MKQ Monovalent cation H antiporter subunit C HUT09_27920 ENOG4108JPZ Monovalent cation H antiporter subunit D HUT09_27935 ENOG4105KJM monovalent cation h antiporter subunit g HUT09_27950 ENOG4106CD9 glycosyl transferase group 1 HUT09_27955 ENOG4108QV3 biosynthesis protein HUT09_27995 ENOG4105C0K Gdp-mannose 4,6-dehydratase HUT09_28000 ENOG4105C30 Nad-dependent epimerase dehydratase HUT09_28005 ENOG4105D3Q Sugar transferase HUT09_28035 ENOG410880H cysteine synthase HUT09_28045 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT09_28080 ENOG4107RIQ Sulfate adenylate transferase HUT09_28100 ENOG4108KB2 LysR family Transcriptional regulator HUT09_28110 ENOG4108KTG Membrane protein, drug metabolite transporter HUT09_28115 ENOG4105F27 Major Facilitator HUT09_28120 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUT09_28145 ENOG4107QM5 aconitate hydratase HUT09_28155 ENOG4107TB6 phosphoglycerate mutase HUT09_28180 ENOG4105E2R ROK family HUT09_28185 ENOG4105DFW ABC transporter HUT09_28190 ENOG4105C2J ABC transporter HUT09_28195 ENOG4108HWW ABC transporter HUT09_28200 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUT09_28205 ENOG4105CUB amino acid HUT09_28215 ENOG4108KGH TRANSCRIPTIONal HUT09_28225 ENOG4107SBE Glycosyl transferase (Group 1 HUT09_28230 ENOG4105C39 capsular polysaccharide phosphotransferase HUT09_28240 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUT09_28245 ENOG4105C39 capsular polysaccharide phosphotransferase HUT09_28250 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT09_28255 ENOG4105CHU acetyl-coa acetyltransferase HUT09_28275 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HUT09_28280 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HUT09_28290 ENOG4105C1Q protoporphyrinogen oxidase HUT09_28295 ENOG4107JTW chlorite dismutase HUT09_28310 ENOG4105E18 UPF0276 protein HUT09_28390 ENOG4105DFU Cell wall formation (By similarity) HUT09_28395 ENOG4105E0X reductase HUT09_28450 ENOG4108MWI inositol mono-phosphatase HUT09_28460 ENOG4105ESN nucleotide-binding protein HUT09_28465 ENOG4108QZR synthase HUT09_28475 ENOG4105CPQ Dehydrogenase HUT09_28480 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HUT09_28485 ENOG4106NZI LysR family Transcriptional regulator HUT09_28495 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HUT09_28500 ENOG4107Z1W Fructose transport system kinase HUT09_28590 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT09_28605 ENOG4106JDR secreted HUT09_28615 ENOG4105BZ1 (ABC) transporter HUT09_28620 ENOG4105BZ1 (ABC) transporter HUT09_28625 ENOG4105MC2 DSBA oxidoreductase HUT09_28635 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT09_28640 ENOG4108IY8 ABC, transporter HUT09_28665 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HUT09_28685 ENOG4107RR1 TRANSCRIPTIONal HUT09_28690 ENOG4105CSU acyl-Coa dehydrogenase HUT09_28710 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT09_28725 ENOG4107RSM transcriptional regulator HUT09_28730 ENOG4105CHU acetyl-coa acetyltransferase HUT09_28775 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUT09_28800 ENOG4105C7K acetolactate synthase HUT09_28825 ENOG4105DRR Transcriptional regulator, GntR family HUT09_28850 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HUT09_28855 ENOG4105C7N Xanthine uracil vitamin C permease HUT09_28860 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HUT09_28865 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT09_28900 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT09_28915 ENOG4107SMB hydrolase Family 5 HUT09_28930 ENOG4105CHF Glutathione S-transferase HUT09_28955 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_28965 ENOG4105XYF acetyltransferase HUT09_28975 ENOG41060W2 glyoxylate carboligase HUT09_29000 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_29010 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT09_29025 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HUT09_29040 ENOG4105CH6 catalase HUT09_29045 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HUT09_29050 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HUT09_29055 ENOG4106R7G Glycoside hydrolase family 5 HUT09_29060 ENOG4105E2D ec 3.2.1.52 HUT09_29080 ENOG4105FDP GntR family transcriptional regulator HUT09_29085 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HUT09_29105 ENOG4105VT2 5-hydroxyisourate hydrolase HUT09_29115 ENOG4105C2W permease HUT09_29120 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUT09_29135 ENOG4105EV9 Alpha Beta Hydrolase HUT09_29160 ENOG4105CSX c4-dicarboxylate anaerobic carrier HUT09_29185 ENOG4107R9S Malate synthase HUT09_29200 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_29220 ENOG4107HP6 Transcriptional regulator HUT09_29235 ENOG4105CV8 reductase HUT09_29240 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HUT09_29265 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_29280 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HUT09_29295 ENOG4105CNN ABC, transporter HUT09_29300 ENOG4105C2J ABC transporter HUT09_29305 ENOG4105DKQ ROK family HUT09_29315 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HUT09_29320 ENOG4105E8R UPF0173 metal-dependent hydrolase HUT09_29335 ENOG4105CHR reductase HUT09_29360 ENOG4105CDA abc transporter atp-binding protein HUT09_29365 ENOG4107UBR Extracellular solute-binding protein family 3 HUT09_29370 ENOG4105EAD ABC transporter HUT09_29375 ENOG4105DRP amino acid AbC transporter HUT09_29395 ENOG4105CAQ asparagine synthetase HUT09_29405 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HUT09_29415 ENOG4108ES0 acetoacetyl-CoA synthetase HUT09_29435 ENOG4105CHR reductase HUT09_29445 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HUT09_29475 ENOG4107SET aldo keto reductase HUT09_29485 ENOG4105C8Y Acetylornithine aminotransferase HUT09_29490 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) HUT09_29510 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HUT09_29520 ENOG4105EGE secreted protein HUT09_29540 ENOG4105E9K Isocitrate dehydrogenase HUT09_29560 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HUT09_29570 ENOG4105CR4 methylisocitrate lyase HUT09_29580 ENOG4105CFF transcriptional regulator HUT09_29600 ENOG4105C1G acyl-Coa dehydrogenase HUT09_29605 ENOG4105C26 Dehydrogenase HUT09_29635 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_29650 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HUT09_29665 ENOG4105C10 Electron transfer flavoprotein HUT09_29705 ENOG4105CGU Enoyl-CoA hydratase HUT09_29725 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HUT09_29740 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HUT09_29745 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HUT09_29750 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT09_29755 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT09_29765 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT09_29775 ENOG4105CIG ABC transporter HUT09_29780 ENOG4105E39 Enoyl-CoA hydratase HUT09_29785 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_29800 ENOG4108UVJ appr-1-p processing domain protein HUT09_29810 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT09_29825 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HUT09_29840 ENOG4105BZW Glycerate kinase HUT09_29850 ENOG4108IV0 ABC, transporter HUT09_29855 ENOG4105C0Z ABC transporter HUT09_29860 ENOG4105C32 Amino acid ABC transporter (Permease) HUT09_29865 ENOG4105C32 Amino acid ABC transporter (Permease) HUT09_29910 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HUT09_29915 ENOG4105C1G acyl-Coa dehydrogenase HUT09_29925 ENOG4105CI0 Citrate lyase HUT09_29955 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT09_29985 ENOG4108M0I Transcriptional regulator HUT09_29990 ENOG4105CPC Aldo Keto reductase HUT09_30000 ENOG4108ME1 Peptidase M55 D-aminopeptidase HUT09_30005 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT09_30015 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HUT09_30030 ENOG4105D9U N-acetyltransferase HUT09_30045 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT09_30065 ENOG4105E8R UPF0173 metal-dependent hydrolase HUT09_30075 ENOG4105ETE Transcriptional regulator (LacI family HUT09_30090 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUT09_30105 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT09_30115 ENOG4106GCT Dehydratase HUT09_30135 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT09_30145 ENOG4105CV8 reductase HUT09_30155 ENOG4107NQ8 LysR family Transcriptional regulator HUT09_30160 ENOG4105DHU Bile acid HUT09_30170 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HUT09_30175 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT09_30185 ENOG4105C2J ABC transporter HUT09_30190 ENOG4105CNN ABC, transporter HUT09_30195 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HUT09_30220 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase HUT09_30280 ENOG4105ETE Transcriptional regulator (LacI family HUT09_30285 ENOG4105C2J ABC transporter HUT09_30290 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HUT09_30295 ENOG4108RVA ribokinase HUT09_30300 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HUT09_30310 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HUT09_30325 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) HUT09_30340 ENOG4105BZU Histidine kinase HUT09_30345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT09_30380 ENOG4108IJ7 Glycine betaine HUT09_30385 ENOG4108HQS Glycine betaine HUT09_30395 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HUT09_30405 ENOG4107WGA YidE YbjL HUT09_30420 ENOG4105CMG Carbohydrate kinase HUT09_30430 ENOG4105DKQ ROK family HUT09_30455 ENOG4105ME7 Membrane HUT09_30460 ENOG4108ZT1 Transcriptional regulator HUT09_30490 ENOG4106A3M Cytochrome p-450 HUT09_30495 ENOG4105F8D glycoside hydrolase family 4 HUT09_30535 ENOG4105K5B UPF0225 protein HUT09_30580 ENOG4105DHJ ABC, transporter HUT09_30670 ENOG4105CSR polyphosphate kinase 2 HUT09_30680 ENOG4105DQE DNA ligase HUT09_30725 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT09_30735 ENOG4105GVF (ABC) transporter HUT09_30740 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUT09_30750 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT09_30760 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT09_30770 ENOG41066F0 sporulation and cell division protein HUT09_30780 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HUT09_30790 ENOG4105EG6 Saccharopine dehydrogenase HUT09_30800 ENOG4105C1G acyl-Coa dehydrogenase HUT09_30805 ENOG4105CHU acetyl-coa acetyltransferase HUT09_30810 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT09_30840 ENOG4105C94 Transporter HUT09_30850 ENOG4105C5H ABC transporter HUT09_30855 ENOG4105BZM domain protein HUT09_30875 ENOG4105E39 Enoyl-CoA hydratase HUT09_30890 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HUT09_30920 ENOG4105D49 3-dehydroquinate synthase HUT09_30940 ENOG4105EY8 ABC transporter HUT09_30945 ENOG4105FBD synthase HUT09_30955 ENOG4107S11 squalene-associated FAD-dependent desaturase HUT09_30965 ENOG4105EWU Squalene--hopene cyclase HUT09_31000 ENOG4105DR5 peptidase HUT09_31005 ENOG41090WU lipolytic protein G-D-S-L family HUT09_31055 ENOG410905P Pyridoxamine 5-phosphate HUT09_31095 ENOG4105ETE Transcriptional regulator (LacI family HUT09_31100 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component HUT09_31110 ENOG4108IY8 ABC, transporter HUT09_31190 ENOG4105DXX methyltransferase HUT09_31255 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT09_31285 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_31290 ENOG4105BZU Histidine kinase HUT09_31300 ENOG4105C6F GntR Family Transcriptional Regulator HUT09_31305 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HUT09_31310 ENOG4107QR9 Iron-sulfur cluster binding protein HUT09_31315 ENOG41080R8 Conserved Protein HUT09_31335 ENOG4107SM8 Adenylate Guanylate cyclase HUT09_31345 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein HUT09_31350 ENOG4105F6S Spore photoproduct lyase HUT09_31415 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT09_31445 ENOG4108TM9 integral membrane protein HUT09_31455 ENOG4105EMN RNA polymerase sigma factor HUT09_31465 ENOG4105ECQ AraC Family Transcriptional Regulator HUT09_31495 ENOG4105EWK phytoene HUT09_31500 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT09_31520 ENOG410650H (LipO)protein HUT09_31525 ENOG4105DBE peroxidase HUT09_31535 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HUT09_31550 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) HUT09_31565 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT09_31575 ENOG4105EZR dyp-type peroxidase family protein HUT09_31580 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HUT09_31595 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HUT09_31600 ENOG4105EBR Carboxylesterase HUT09_31605 ENOG4107TXC Transcriptional regulator HUT09_31625 ENOG4106T9R serine protease HUT09_31650 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUT09_31665 ENOG4105E2R ROK family HUT09_31670 ENOG4105ETE Transcriptional regulator (LacI family HUT09_31675 ENOG4105MS9 Resuscitation-promoting factor HUT09_31715 ENOG4105BZU Histidine kinase HUT09_31720 ENOG4107YTP response regulator receiver protein HUT09_31725 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_31780 ENOG4108NEV two component transcriptional regulator, LytTR family HUT09_31795 ENOG4108HRK Histidine kinase HUT09_31865 ENOG4105BZU Histidine kinase HUT09_31870 ENOG4105DND Transcriptional regulator HUT09_31885 ENOG4105E33 succinate dehydrogenase HUT09_31895 ENOG4105DEN Luciferase family HUT09_31905 ENOG4105WKW Pfam:DUF1458 HUT09_31925 ENOG41067HS methyltransferase HUT09_31930 ENOG4108V75 Glutamine amidotransferase HUT09_31935 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HUT09_31940 ENOG4105D1K glutamate--cysteine ligase HUT09_31960 ENOG41080RH Thioredoxin HUT09_31965 ENOG4107QN2 dihydrolipoyl dehydrogenase HUT09_31970 ENOG4105CSV Glutaminase HUT09_31975 ENOG4107QPH glycogen) synthase HUT09_31980 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HUT09_31990 ENOG4105C57 major facilitator superfamily HUT09_32035 ENOG4108W6C Dehydrogenase HUT09_32040 ENOG4105CF7 AraC family transcriptional regulator HUT09_32055 ENOG4105CHR reductase HUT09_32070 ENOG4105CIK Amidinotransferase HUT09_32125 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT09_32145 ENOG4105EUB pirin domain protein HUT09_32170 ENOG4105R1U AraC Family Transcriptional Regulator HUT09_32175 ENOG4105EU0 Major facilitator Superfamily HUT09_32200 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT09_32210 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_32215 ENOG4105C3U ABC transporter HUT09_32220 ENOG4108JQ7 (ABC) transporter HUT09_32230 ENOG4107SCK Monooxygenase HUT09_32260 ENOG4105ETE Transcriptional regulator (LacI family HUT09_32265 ENOG4105D4B ABC, transporter HUT09_32270 ENOG4105F5R ABC transporter HUT09_32275 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HUT09_32280 ENOG4105C2J ABC transporter HUT09_32295 ENOG4105DET Rhamnulokinase HUT09_32305 ENOG4105S6R Iron-hydroxamate transporter permease subunit HUT09_32310 ENOG4105J76 Periplasmic binding protein HUT09_32315 ENOG4105E0A ABC, transporter HUT09_32330 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUT09_32340 ENOG4105NRA 50s ribosomal protein l31 type b HUT09_32345 ENOG4105W0E 50S ribosomal protein L33 HUT09_32350 ENOG4105KDC 50s ribosomal protein l28 HUT09_32355 ENOG41082R9 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUT09_32360 ENOG41068HZ 50S ribosomal protein L32 HUT09_32375 ENOG4108U1V ABC transporter, permease HUT09_32380 ENOG4105DQ5 transport system permease protein HUT09_32385 ENOG4105E0A ABC, transporter HUT09_32415 ENOG4105BZ1 (ABC) transporter HUT09_32460 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT09_32470 ENOG4105CJR Integral membrane protein (MviN HUT09_32480 ENOG4105D3Q Sugar transferase HUT09_32510 ENOG4105E90 ABC transporter HUT09_32515 ENOG4105E90 ABC transporter HUT09_32530 ENOG4108IJ8 ABC transporter HUT09_32540 ENOG4108V62 Rhodanese domain protein HUT09_32555 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT09_32560 ENOG4105D2B acyl-CoA dehydrogenase HUT09_32565 ENOG4105D2B acyl-CoA dehydrogenase HUT09_32585 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_32590 ENOG4105C3U ABC transporter HUT09_32595 ENOG4108JQ7 (ABC) transporter HUT09_32655 ENOG4105DCG PHP domain protein HUT09_32745 ENOG4105VEQ Cold shock protein HUT09_32760 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HUT09_32765 ENOG4108Z0Z intracellular protease Pfpi family HUT09_32775 ENOG4105CQS hydrogenase expression formation protein HypD HUT09_32795 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HUT09_32800 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HUT09_32845 ENOG41065HY 1,4-beta-cellobiosidase HUT09_32850 ENOG4105E2B Taurine dioxygenase HUT09_32860 ENOG4105ETE Transcriptional regulator (LacI family HUT09_32915 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HUT09_32935 ENOG4105C26 Dehydrogenase HUT09_32940 ENOG4107RR1 TRANSCRIPTIONal HUT09_32955 ENOG4105C0D helicase HUT09_33010 ENOG41082SX arsR family transcriptional regulator HUT09_33025 ENOG4105GWZ Roadblock lc7 family protein HUT09_33050 ENOG4105E39 Enoyl-CoA hydratase HUT09_33085 ENOG4105VBF alkaline shock protein HUT09_33090 ENOG4105EMN RNA polymerase sigma factor HUT09_33105 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HUT09_33110 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT09_33125 ENOG4105K4I Scp-like extracellular HUT09_33135 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT09_33155 ENOG4106NZI LysR family Transcriptional regulator HUT09_33170 ENOG4107JC6 Membrane HUT09_33175 ENOG4105C5H ABC transporter HUT09_33200 ENOG4107RTD sua5 ycio yrdc ywlc family protein HUT09_33255 ENOG4105CVN desaturase HUT09_33290 ENOG4108Z6Z Transcriptional regulator HUT09_33295 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HUT09_33310 ENOG4105I9Z UPF0264 protein HUT09_33320 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT09_33370 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUT09_33375 ENOG4105C5I Dehydrogenase HUT09_33380 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HUT09_33390 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT09_33415 ENOG4106NZI LysR family Transcriptional regulator HUT09_33485 ENOG4105EMU Dehydrogenase HUT09_33520 ENOG4105ERH Fumarylacetoacetate hydrolase HUT09_33525 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_33540 ENOG4105C57 major facilitator superfamily HUT09_33560 ENOG4105C26 Dehydrogenase HUT09_33605 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_33615 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HUT09_33650 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUT09_33680 ENOG4105WN5 stage II sporulation protein HUT09_33715 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT09_33730 ENOG4105MHT Transcriptional regulator, ARSR family HUT09_33765 ENOG4105E0A ABC, transporter HUT09_33770 ENOG4105CC5 ABC transporter HUT09_33810 ENOG4105VNT transposase (IS4 family) protein HUT09_33855 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HUT09_34000 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUT09_34050 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_34215 ENOG4105CHH sulfate transporter HUT09_34225 ENOG4105EUZ Beta-lactamase domain protein HUT09_34345 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT09_34350 ENOG4108Y6J UPF0403 protein HUT09_34360 ENOG4107QPD alcohol dehydrogenase HUT09_34365 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HUT09_34370 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) HUT09_34425 ENOG4105VNT transposase (IS4 family) protein HUT09_34495 ENOG4107QQG Dehydrogenase HUT09_34505 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT09_34520 ENOG4105DXX methyltransferase HUT09_34535 ENOG4105CV8 reductase HUT09_34600 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HUT09_34620 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT09_34670 ENOG4105CUB amino acid HUT09_34695 ENOG4105EYF MMPL domain protein HUT09_34700 ENOG4105BZU Histidine kinase HUT09_34705 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_34725 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT09_34770 ENOG4105EIP mannose-6-phosphate isomerase HUT09_34790 ENOG4105DRS transport system, permease HUT09_34850 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUT09_34890 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_34950 ENOG4105CBC glutamate synthase HUT09_34955 ENOG4105C7K acetolactate synthase HUT09_34960 ENOG4105MXW flavin reductase domain protein, FMN-binding HUT09_34980 ENOG4107R6F Alpha Beta Hydrolase Fold protein HUT09_34990 ENOG4105WN5 stage II sporulation protein HUT09_35000 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_35020 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HUT09_35030 ENOG4107MMM Anti-sigma-factor antagonist HUT09_35075 ENOG4105VEQ Cold shock protein HUT09_35080 ENOG4105C1J atp-dependent rna helicase HUT09_35190 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUT09_35215 ENOG4108KB2 LysR family Transcriptional regulator HUT09_35220 ENOG4105F27 Major Facilitator HUT09_35235 ENOG4108M9J MaoC like domain protein HUT09_35245 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUT09_35250 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUT09_35255 ENOG4105CAQ asparagine synthetase HUT09_35270 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUT09_35290 ENOG4105BZ1 (ABC) transporter HUT09_35330 ENOG4105C1G acyl-Coa dehydrogenase HUT09_35345 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT09_35430 ENOG4105MP0 transposase HUT09_35470 ENOG4105CKK Glycosyl transferase, family 2 HUT09_35525 ENOG4105D5G Transposase HUT09_35550 ENOG4107MM9 BNR Asp-box repeat-containing protein HUT09_35555 ENOG4108JQ7 (ABC) transporter HUT09_35565 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT09_35570 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_35575 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT09_35580 ENOG4107T6F Xaa-Pro aminopeptidase HUT09_35585 ENOG4105DRR Transcriptional regulator, GntR family HUT09_35590 ENOG4105CIF Ornithine Cyclodeaminase HUT09_35595 ENOG4105CTU Proline racemase HUT09_35600 ENOG4105CTU Proline racemase HUT09_35620 ENOG4105MWK D-amino acid dehydrogenase, small subunit HUT09_35695 ENOG4108HMN Caspase domain HUT09_35785 ENOG4105CPC Aldo Keto reductase HUT09_35790 ENOG4106448 streptomycin biosynthesis protein strI HUT09_35805 ENOG4108W6C Dehydrogenase HUT09_35835 ENOG4105WQT MbtH domain protein HUT09_35870 ENOG4105PTV Nudix Hydrolase HUT09_35885 ENOG4105MP0 transposase HUT09_35945 ENOG41065KQ synthase HUT09_35955 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HUT09_36000 ENOG4105CFG Acts as a chaperone (By similarity) HUT09_36060 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) HUT09_36065 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HUT09_36085 ENOG4105FB9 CRISPR-associated protein HUT09_36215 ENOG4105CPC Aldo Keto reductase HUT09_36270 ENOG4108RWI nicotinamidase HUT09_36335 ENOG4105CH6 catalase HUT09_36395 ENOG4107QJE Chromosome Partitioning Protein HUT09_36425 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUT09_36435 ENOG4105KAV tspo and mbr like protein HUT09_36455 ENOG4105C0B DNA polymerase III (alpha subunit) HUT09_36470 ENOG4105FDF Could be involved in DNA repair (By similarity) HUT09_36635 ENOG410836F Transposase HUT09_36650 ENOG4105CYP glycoside hydrolase, family HUT09_36695 ENOG4105CV8 reductase HUT09_36705 ENOG4105KVH Transcriptional regulator HUT09_36835 ENOG4108KEZ Dehydrogenase HUT09_36840 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT09_36895 ENOG4105CHH sulfate transporter HUT09_36905 ENOG4105EUZ Beta-lactamase domain protein HUT09_36960 ENOG4105CDU Replicative dna helicase HUT09_37030 ENOG4105FA0 parb-like partition protein HUT09_37135 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)