locus-tag class description GJU35_00050 ENOG4108IG5 Transcriptional regulator GJU35_00075 ENOG4108IG5 Transcriptional regulator GJU35_00085 ENOG4105ETE Transcriptional regulator (LacI family GJU35_00140 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GJU35_00165 ENOG41067SE Tetr family transcriptional regulator GJU35_00170 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GJU35_00175 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GJU35_00180 ENOG4105C1G acyl-Coa dehydrogenase GJU35_00190 ENOG4105DYW oxidoreductase GJU35_00205 ENOG4105CHR reductase GJU35_00215 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GJU35_00225 ENOG4105CEY Amp-dependent synthetase and ligase GJU35_00275 ENOG4105CPQ Dehydrogenase GJU35_00285 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate GJU35_00290 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) GJU35_00295 ENOG4105E98 transcriptional regulator DeoR family GJU35_00460 ENOG4105F27 Major Facilitator GJU35_00465 ENOG4105C1J atp-dependent rna helicase GJU35_00475 ENOG4105D5G Transposase GJU35_00490 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GJU35_00495 ENOG4105C26 Dehydrogenase GJU35_00505 ENOG41060BG Tetr family transcriptional regulator GJU35_00510 ENOG4108VHC Short-chain dehydrogenase reductase Sdr GJU35_00530 ENOG4107QP6 Xylose isomerase domain protein TIM barrel GJU35_00535 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GJU35_00545 ENOG4107TTA Xylose isomerase domain protein TIM barrel GJU35_00550 ENOG4105ETE Transcriptional regulator (LacI family GJU35_00615 ENOG4107QPV Serine Threonine protein kinase GJU35_00630 ENOG4107S9F NmrA family GJU35_00635 ENOG4105D7V transposase GJU35_00780 ENOG4106R7G Glycoside hydrolase family 5 GJU35_00810 ENOG4107RSM transcriptional regulator GJU35_00815 ENOG4105CHR reductase GJU35_00845 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GJU35_00885 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GJU35_01005 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) GJU35_01060 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GJU35_01100 ENOG4108KPJ rna polymerase sigma factor GJU35_01115 ENOG4108KPJ rna polymerase sigma factor GJU35_01120 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GJU35_01150 ENOG4108IND Tetr family transcriptional regulator GJU35_01155 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GJU35_01185 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component GJU35_01200 ENOG4105ETE Transcriptional regulator (LacI family GJU35_01205 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GJU35_01210 ENOG4105C19 ABC transporter GJU35_01225 ENOG4105E3W Two component transcriptional regulator (Winged helix family GJU35_01230 ENOG4105EB3 Histidine kinase GJU35_01240 ENOG4105KVH Transcriptional regulator GJU35_01255 ENOG4105E0A ABC, transporter GJU35_01260 ENOG4105EHG Permease protein GJU35_01305 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GJU35_01355 ENOG4105KVH Transcriptional regulator GJU35_01415 ENOG4105T1M mycothiol conjugate amidase mca GJU35_01435 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GJU35_01440 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GJU35_01470 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GJU35_01475 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GJU35_01480 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GJU35_01510 ENOG4105JAB phenazine biosynthesis protein, phzf family GJU35_01515 ENOG4105DYW oxidoreductase GJU35_01525 ENOG4105C5H ABC transporter GJU35_01550 ENOG4105BZU Histidine kinase GJU35_01555 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_01560 ENOG4105VUN Transcriptional regulator GJU35_01595 ENOG4108KPJ rna polymerase sigma factor GJU35_01610 ENOG4105BZU Histidine kinase GJU35_01615 ENOG4105EYF MMPL domain protein GJU35_01620 ENOG41062IR nudix hydrolase GJU35_01630 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GJU35_01645 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase GJU35_01675 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GJU35_01710 ENOG41069M3 Transcriptional regulator GJU35_01725 ENOG4105DRP amino acid AbC transporter GJU35_01730 ENOG4105CDA abc transporter atp-binding protein GJU35_01735 ENOG4107UH8 sugar kinase GJU35_01770 ENOG4105KVH Transcriptional regulator GJU35_01775 ENOG4105DEF Extracellular solute-binding protein, family 5 GJU35_01790 ENOG4105C3U ABC transporter GJU35_01795 ENOG4108JQ7 (ABC) transporter GJU35_01805 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GJU35_01815 ENOG4105CEP NADH dehydrogenase GJU35_01825 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein GJU35_01900 ENOG4108YYC ycei family GJU35_01905 ENOG4107QN1 sodium solute GJU35_01920 ENOG4105CYW agmatinase GJU35_01925 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GJU35_01935 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GJU35_01940 ENOG4105BZU Histidine kinase GJU35_01945 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_01960 ENOG4105EHG Permease protein GJU35_01965 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GJU35_01990 ENOG4105F0K SARP family transcriptional regulator GJU35_02015 ENOG4105EBM Alpha Beta Hydrolase Fold protein GJU35_02035 ENOG4107SWG transcriptional regulator MERR family GJU35_02040 ENOG4107RTD sua5 ycio yrdc ywlc family protein GJU35_02050 ENOG4105BZU Histidine kinase GJU35_02085 ENOG4108HKT sucrose-6-phosphate hydrolase GJU35_02095 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GJU35_02130 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GJU35_02145 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_02155 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GJU35_02160 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) GJU35_02185 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GJU35_02235 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) GJU35_02245 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) GJU35_02250 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GJU35_02255 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) GJU35_02290 ENOG4107MMM Anti-sigma-factor antagonist GJU35_02295 ENOG4105FUA antagonist GJU35_02300 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GJU35_02315 ENOG4105CEP NADH dehydrogenase GJU35_02335 ENOG4108TM9 integral membrane protein GJU35_02360 ENOG4105CXN decarboxylase GJU35_02370 ENOG4105E8G Major facilitator Superfamily GJU35_02405 ENOG4105BZU Histidine kinase GJU35_02410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GJU35_02425 ENOG4105K78 MarR family Transcriptional regulator GJU35_02445 ENOG4105C5X domain protein GJU35_02465 ENOG4105C3M thioredoxin reductase GJU35_02470 ENOG4105CUX Signal transduction histidine kinase GJU35_02480 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_02500 ENOG4105EX0 alpha-galactosidase GJU35_02505 ENOG4105E2R ROK family GJU35_02515 ENOG4105K4I Scp-like extracellular GJU35_02535 ENOG4105C7B Threonine dehydratase GJU35_02540 ENOG4107QPV Serine Threonine protein kinase GJU35_02550 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GJU35_02560 ENOG4105KF0 sporulation and cell division protein, SsgA GJU35_02580 ENOG4107SET aldo keto reductase GJU35_02610 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GJU35_02620 ENOG4105ESN nucleotide-binding protein GJU35_02630 ENOG4108PA7 Methyltransferase GJU35_02650 ENOG4105CIR epoxide hydrolase GJU35_02655 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GJU35_02660 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GJU35_02665 ENOG4105WBV Transcriptional regulator GJU35_02670 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GJU35_02675 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GJU35_02700 ENOG4105D9P serine threonine protein kinase GJU35_02710 ENOG4105IDI abc transporter atp-binding protein GJU35_02730 ENOG4105CPC Aldo Keto reductase GJU35_02735 ENOG4107RSM transcriptional regulator GJU35_02745 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GJU35_02750 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase GJU35_02765 ENOG4107S5I aldo keto reductase GJU35_02775 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GJU35_02780 ENOG4105C26 Dehydrogenase GJU35_02800 ENOG4105FBW Monooxygenase GJU35_02820 ENOG4105FBW Monooxygenase GJU35_02840 ENOG4105CVP deoxyribo-dipyrimidine photolyase GJU35_02910 ENOG4105CMR udp-glucose 4-epimerase GJU35_02915 ENOG4105C6Y Udp-glucose 6-dehydrogenase GJU35_02920 ENOG4105C1B dTDP-glucose 4-6-dehydratase GJU35_02930 ENOG4105BZU Histidine kinase GJU35_02940 ENOG4105BZP glycoside hydrolase 15-related GJU35_02960 ENOG4105CAQ asparagine synthetase GJU35_03015 ENOG4108YV4 Universal stress protein GJU35_03040 ENOG4105E39 Enoyl-CoA hydratase GJU35_03060 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) GJU35_03110 ENOG4105CEY Amp-dependent synthetase and ligase GJU35_03145 ENOG4105FDP GntR family transcriptional regulator GJU35_03160 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GJU35_03170 ENOG4108IYU L-aspartate oxidase GJU35_03185 ENOG4105EAB amino acid AbC transporter GJU35_03190 ENOG4105CDA abc transporter atp-binding protein GJU35_03195 ENOG4105E5Q amino acid AbC transporter GJU35_03205 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GJU35_03210 ENOG4107NHD transcriptional regulator GJU35_03265 ENOG4105ETE Transcriptional regulator (LacI family GJU35_03270 ENOG4107T3P ABC, transporter GJU35_03285 ENOG4105CG3 alpha amylase, catalytic region GJU35_03325 ENOG4108IXY short-chain dehydrogenase reductase GJU35_03335 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GJU35_03340 ENOG4105BZU Histidine kinase GJU35_03345 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_03415 ENOG4108TKH Nitroreductase GJU35_03435 ENOG4108VHC Short-chain dehydrogenase reductase Sdr GJU35_03440 ENOG4106UW1 Major Facilitator superfamily GJU35_03450 ENOG4105CN5 Metallo-Beta-Lactamase GJU35_03495 ENOG4107TDE lipolytic protein G-D-S-L family GJU35_03525 ENOG4107S1E Beta-lactamase GJU35_03560 ENOG4108EU3 peptide transport system, permease GJU35_03565 ENOG4105EW9 transcriptional regulator AsnC family GJU35_03585 ENOG4107SWG transcriptional regulator MERR family GJU35_03600 ENOG4105CHR reductase GJU35_03610 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 GJU35_03620 ENOG4108IG5 Transcriptional regulator GJU35_03630 ENOG4105E1F short-chain dehydrogenase reductase GJU35_03640 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GJU35_03660 ENOG4105DXX methyltransferase GJU35_03695 ENOG4105ETE Transcriptional regulator (LacI family GJU35_03705 ENOG4105ERH Fumarylacetoacetate hydrolase GJU35_03715 ENOG41061H0 Monooxygenase GJU35_03730 ENOG4105ERH Fumarylacetoacetate hydrolase GJU35_03740 ENOG41060NJ transcriptional regulator GJU35_03745 ENOG4105ETE Transcriptional regulator (LacI family GJU35_03775 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GJU35_03780 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GJU35_03790 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GJU35_03810 ENOG4108HMN Caspase domain GJU35_03845 ENOG4108JA1 polyketide synthase GJU35_03875 ENOG4105I6B RNA polymerase GJU35_03905 ENOG4105X7H acyl-CoA dehydrogenase GJU35_03940 ENOG4105CEY Amp-dependent synthetase and ligase GJU35_03950 ENOG4105CEY Amp-dependent synthetase and ligase GJU35_03975 ENOG4105CDH Citrulline--aspartate ligase GJU35_03985 ENOG41082AN stage II sporulation protein GJU35_04000 ENOG4105CMT Dihydroxyacetone kinase GJU35_04010 ENOG4108UTZ Dihydroxyacetone kinase GJU35_04055 ENOG4105CHR reductase GJU35_04065 ENOG4105CYP glycoside hydrolase, family GJU35_04085 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GJU35_04105 ENOG4107S91 Sodium hydrogen exchanger GJU35_04150 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GJU35_04185 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GJU35_04190 ENOG4105I82 acetyl xylan esterase GJU35_04200 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) GJU35_04215 ENOG4105F76 Sarcosine oxidase GJU35_04220 ENOG4107W6X Transcriptional regulator GJU35_04240 ENOG4105DZ1 carboxypeptidase GJU35_04245 ENOG4108VJY integral membrane protein GJU35_04250 ENOG4107JC6 Membrane GJU35_04255 ENOG4105CSV Glutaminase GJU35_04260 ENOG4108IJ0 Aspartate ammonia-lyase GJU35_04275 ENOG41073TP transcriptional regulator GJU35_04280 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GJU35_04290 ENOG4105KJJ Uncharacterized ACR, COG1993 GJU35_04295 ENOG41083YR Protein CrcB homolog GJU35_04315 ENOG4105ETE Transcriptional regulator (LacI family GJU35_04330 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) GJU35_04345 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GJU35_04360 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GJU35_04375 ENOG4105CQB FAD linked oxidase domain protein GJU35_04390 ENOG4108KC1 acyl-Coa dehydrogenase GJU35_04440 ENOG4105CFG Acts as a chaperone (By similarity) GJU35_04485 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein GJU35_04495 ENOG4108UHU Aldolase GJU35_04515 ENOG4105C01 Dihydroxy-acid dehydratase GJU35_04520 ENOG4105CPQ Dehydrogenase GJU35_04565 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GJU35_04575 ENOG4105ETE Transcriptional regulator (LacI family GJU35_04585 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) GJU35_04605 ENOG4105EEM helicase GJU35_04610 ENOG4105EQ0 Major Facilitator superfamily GJU35_04620 ENOG4105GVJ transcriptional regulator GJU35_04625 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GJU35_04640 ENOG4105VPX protein, conserved in bacteria GJU35_04665 ENOG4105JXH GntR family transcriptional regulator GJU35_04675 ENOG4105DK0 Indole-3-glycerol phosphate synthase GJU35_04690 ENOG4107SET aldo keto reductase GJU35_04705 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GJU35_04720 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GJU35_04730 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase GJU35_04755 ENOG4105CQB FAD linked oxidase domain protein GJU35_04760 ENOG4108JPW Aminotransferase GJU35_04780 ENOG4107R13 MMPL domain protein GJU35_04795 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_04800 ENOG4105BZU Histidine kinase GJU35_04805 ENOG4105EYF MMPL domain protein GJU35_04810 ENOG4105W1Y Transcriptional regulator GJU35_04825 ENOG41082YX Transcriptional regulator, arsr family GJU35_04830 ENOG4105H3G oxidoreductase GJU35_04865 ENOG4105ECP epimerase GJU35_04880 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family GJU35_04890 ENOG4105FDP GntR family transcriptional regulator GJU35_04895 ENOG4105MWK D-amino acid dehydrogenase, small subunit GJU35_04905 ENOG4105CIR epoxide hydrolase GJU35_04920 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GJU35_04930 ENOG4105CHR reductase GJU35_04935 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GJU35_04955 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GJU35_05000 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GJU35_05040 ENOG4105MVE transcriptional regulator GJU35_05055 ENOG4108Q50 Histidine kinase GJU35_05065 ENOG4105C6T cysteine synthase GJU35_05080 ENOG4107R34 abc transporter permease protein GJU35_05120 ENOG4108YZG isomerase GJU35_05125 ENOG4105D1H recombination factor protein RarA GJU35_05140 ENOG4105DKQ ROK family GJU35_05150 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) GJU35_05170 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GJU35_05175 ENOG4105E98 transcriptional regulator DeoR family GJU35_05180 ENOG4105BZP glycoside hydrolase 15-related GJU35_05185 ENOG4105E8G Major facilitator Superfamily GJU35_05205 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GJU35_05210 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GJU35_05250 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_05275 ENOG4108MRH transcriptional regulatory protein GJU35_05300 ENOG4108KGH TRANSCRIPTIONal GJU35_05350 ENOG4105MWK D-amino acid dehydrogenase, small subunit GJU35_05355 ENOG4105CDA abc transporter atp-binding protein GJU35_05365 ENOG4105EAB amino acid AbC transporter GJU35_05380 ENOG4106IPI cyclase, family GJU35_05395 ENOG4105ETE Transcriptional regulator (LacI family GJU35_05400 ENOG4105CPC Aldo Keto reductase GJU35_05415 ENOG41061H0 Monooxygenase GJU35_05435 ENOG41073TP transcriptional regulator GJU35_05460 ENOG4105C3U ABC transporter GJU35_05465 ENOG4108JQ7 (ABC) transporter GJU35_05495 ENOG4107W6X Transcriptional regulator GJU35_05530 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GJU35_05535 ENOG41080V6 ABC-3 protein GJU35_05545 ENOG4105DBE peroxidase GJU35_05550 ENOG4105E98 transcriptional regulator DeoR family GJU35_05565 ENOG4105D9P serine threonine protein kinase GJU35_05590 ENOG4105DXI Major Facilitator superfamily GJU35_05595 ENOG4105EQX glucarate dehydratase GJU35_05600 ENOG4105C6Z Gluconate GJU35_05605 ENOG4107HP6 Transcriptional regulator GJU35_05625 ENOG4106UW1 Major Facilitator superfamily GJU35_05645 ENOG4106HB6 Alpha beta hydrolase GJU35_05660 ENOG4105W1Y Transcriptional regulator GJU35_05665 ENOG4105CHH sulfate transporter GJU35_05675 ENOG4105GRZ Ycii-related protein GJU35_05680 ENOG4105CHP RNA polymerase GJU35_05705 ENOG4108WYP Transcriptional regulator GJU35_05755 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) GJU35_05760 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GJU35_05765 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GJU35_05780 ENOG4105F44 Two component transcriptional regulator, winged helix family GJU35_05785 ENOG4106F60 Histidine kinase GJU35_05795 ENOG4108762 serine threonine protein kinase GJU35_05825 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) GJU35_05830 ENOG4105ETE Transcriptional regulator (LacI family GJU35_05900 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GJU35_05910 ENOG4105F6U Short-chain dehydrogenase reductase Sdr GJU35_05925 ENOG4105CPT Alpha beta hydrolase GJU35_05935 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GJU35_05950 ENOG4108RNG Permease of the drug metabolite transporter GJU35_05955 ENOG4106T9R serine protease GJU35_05965 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GJU35_05970 ENOG4105CI0 Citrate lyase GJU35_05975 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GJU35_05980 ENOG4105F04 LysR family Transcriptional regulator GJU35_05985 ENOG4105D4T Citrate transporter GJU35_06025 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_06030 ENOG4105BZU Histidine kinase GJU35_06035 ENOG4107R13 MMPL domain protein GJU35_06055 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GJU35_06060 ENOG4107PP3 Acetylornithine deacetylase GJU35_06070 ENOG4108JQ7 (ABC) transporter GJU35_06075 ENOG4105C3U ABC transporter GJU35_06080 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GJU35_06085 ENOG4105DEF Extracellular solute-binding protein, family 5 GJU35_06090 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GJU35_06095 ENOG4105I1F Resistance protein GJU35_06105 ENOG4105ECP epimerase GJU35_06115 ENOG41060NJ transcriptional regulator GJU35_06125 ENOG4108DT4 serine threonine protein kinase GJU35_06140 ENOG4105C10 Electron transfer flavoprotein GJU35_06165 ENOG4105PSQ Acyl-transferase GJU35_06200 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GJU35_06250 ENOG410841Q phosphoesterase PA-phosphatase related protein GJU35_06280 ENOG4105EQH reductase GJU35_06290 ENOG4105YVS arsR family transcriptional regulator GJU35_06295 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GJU35_06300 ENOG4107S46 esterase, PHB depolymerase GJU35_06315 ENOG4105CSU acyl-Coa dehydrogenase GJU35_06350 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GJU35_06365 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GJU35_06380 ENOG4107VXZ Hydrolase GJU35_06390 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GJU35_06400 ENOG4107SM8 Adenylate Guanylate cyclase GJU35_06440 ENOG4105E0S extracellular solute-binding protein family 1 GJU35_06445 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component GJU35_06450 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GJU35_06460 ENOG4105EQX glucarate dehydratase GJU35_06530 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GJU35_06550 ENOG4105DEI Mannitol dehydrogenase GJU35_06560 ENOG4105CPQ Dehydrogenase GJU35_06580 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GJU35_06620 ENOG4105DV0 amidase (EC 3.5.1.4 GJU35_06625 ENOG4105MWK D-amino acid dehydrogenase, small subunit GJU35_06680 ENOG4107ZED Uncharacterised protein family UPF0047 GJU35_06685 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GJU35_06690 ENOG4105E2Y ABC, transporter GJU35_06700 ENOG4105H3G oxidoreductase GJU35_06710 ENOG4105BZ1 (ABC) transporter GJU35_06720 ENOG4105CK2 sodium dicarboxylate symporter GJU35_06735 ENOG4105BZ1 (ABC) transporter GJU35_06740 ENOG4105BZ1 (ABC) transporter GJU35_06750 ENOG4105NRA 50s ribosomal protein l31 type b GJU35_06765 ENOG4105C29 acyl-CoA thioesterase GJU35_06775 ENOG4105GWZ Roadblock lc7 family protein GJU35_06805 ENOG4105BZU Histidine kinase GJU35_06835 ENOG4105C0D helicase GJU35_06855 ENOG4105C93 Xylose Isomerase GJU35_06865 ENOG4105E2R ROK family GJU35_06870 ENOG4107SCA Formamidase (EC 3.5.1.49) GJU35_06875 ENOG4107RR1 TRANSCRIPTIONal GJU35_06880 ENOG4105C26 Dehydrogenase GJU35_06900 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GJU35_06905 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) GJU35_06925 ENOG4105ETE Transcriptional regulator (LacI family GJU35_06935 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GJU35_06955 ENOG4105C01 Dihydroxy-acid dehydratase GJU35_07035 ENOG4105C9B Cysteine desulfurase GJU35_07040 ENOG4108MIC Mg-protoporphyrin IX methyl transferase GJU35_07050 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GJU35_07055 ENOG4105C0W non-ribosomal peptide synthetase GJU35_07060 ENOG4105C0W non-ribosomal peptide synthetase GJU35_07105 ENOG4105C57 major facilitator superfamily GJU35_07115 ENOG4108JQ6 ABC transporter GJU35_07130 ENOG4105D5P Methylmalonyl-coA mutase GJU35_07140 ENOG4105EG2 ABC transporter, permease GJU35_07150 ENOG4107FKK extracellular solute-binding protein family 1 GJU35_07155 ENOG4105ETE Transcriptional regulator (LacI family GJU35_07170 ENOG4105BZU Histidine kinase GJU35_07200 ENOG4105D2B acyl-CoA dehydrogenase GJU35_07205 ENOG4105D2B acyl-CoA dehydrogenase GJU35_07210 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GJU35_07220 ENOG4105C3M thioredoxin reductase GJU35_07225 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) GJU35_07245 ENOG41065KQ synthase GJU35_07250 ENOG4106A3M Cytochrome p-450 GJU35_07260 ENOG4105C1G acyl-Coa dehydrogenase GJU35_07270 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GJU35_07275 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GJU35_07280 ENOG4105F1K Glutamine amidotransferase GJU35_07285 ENOG4105CTQ phosphohexokinase GJU35_07300 ENOG4105D9P serine threonine protein kinase GJU35_07310 ENOG4108HRK Histidine kinase GJU35_07325 ENOG4108NEV two component transcriptional regulator, LytTR family GJU35_07335 ENOG4105CIK Amidinotransferase GJU35_07340 ENOG4105C8Y Acetylornithine aminotransferase GJU35_07390 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) GJU35_07400 ENOG4105CQM Urea amidohydrolase subunit alpha GJU35_07405 ENOG4105KI2 Urea amidohydrolase subunit beta GJU35_07410 ENOG4108YZ9 Urea amidohydrolase subunit gamma GJU35_07415 ENOG4108Q5F Tetr family transcriptional regulator GJU35_07445 ENOG4105E2R ROK family GJU35_07465 ENOG4105CUV Homoserine Kinase GJU35_07485 ENOG4105CDA abc transporter atp-binding protein GJU35_07490 ENOG4108HW4 amino acid AbC transporter GJU35_07495 ENOG4105EAB amino acid AbC transporter GJU35_07500 ENOG4105CHR reductase GJU35_07510 ENOG4105KME endoribonuclease L-psp GJU35_07525 ENOG4105CHR reductase GJU35_07530 ENOG4105CJP fad dependent oxidoreductase GJU35_07570 ENOG4105N14 lysine exporter protein LysE YggA GJU35_07575 ENOG4105DDW LysR family Transcriptional regulator GJU35_07595 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GJU35_07600 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GJU35_07605 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GJU35_07610 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GJU35_07625 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GJU35_07645 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GJU35_07650 ENOG4105FBW Monooxygenase GJU35_07660 ENOG4108R6G acetyltransferase GJU35_07685 ENOG4105C83 adenylosuccinate lyase GJU35_07690 ENOG4108VCA G U mismatch-specific DNA glycosylase GJU35_07710 ENOG4105BZU Histidine kinase GJU35_07715 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_07720 ENOG4105DKQ ROK family GJU35_07725 ENOG4105FDP GntR family transcriptional regulator GJU35_07730 ENOG4108KPJ rna polymerase sigma factor GJU35_07735 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 GJU35_07740 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GJU35_07750 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GJU35_07760 ENOG4108PSK reductase GJU35_07780 ENOG4105EYH Exonuclease GJU35_07785 ENOG4107RH8 nuclease SbcCD subunit D GJU35_07820 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GJU35_07830 ENOG4105C8N cysteinyl-tRNA synthetase GJU35_07835 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 GJU35_07850 ENOG4105F38 ABC transporter, permease GJU35_07860 ENOG4108TZY GntR Family Transcriptional Regulator GJU35_07870 ENOG4105VEQ Cold shock protein GJU35_07880 ENOG4105K4P CoA-binding domain protein GJU35_07885 ENOG4107QTZ amino acid GJU35_07895 ENOG41082SX arsR family transcriptional regulator GJU35_07920 ENOG4108UW5 maltose o-acetyltransferase GJU35_07925 ENOG4108Z0R Transferase GJU35_07960 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GJU35_07970 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GJU35_07995 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GJU35_08010 ENOG4105CHU acetyl-coa acetyltransferase GJU35_08020 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GJU35_08040 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GJU35_08045 ENOG4105EP9 oxidoreductase GJU35_08065 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GJU35_08070 ENOG4105DEF Extracellular solute-binding protein, family 5 GJU35_08075 ENOG4105CHR reductase GJU35_08110 ENOG4105JQN Transcriptional regulator GJU35_08115 ENOG4108Q5Y Membrane GJU35_08120 ENOG4105CSW GntR family transcriptional regulator GJU35_08155 ENOG4105NTW Transcriptional regulator GJU35_08160 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GJU35_08165 ENOG4105JAB phenazine biosynthesis protein, phzf family GJU35_08195 ENOG4105ETE Transcriptional regulator (LacI family GJU35_08220 ENOG4105DSG hydrolase family 43 GJU35_08250 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GJU35_08260 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GJU35_08325 ENOG4105C5Y PTS System GJU35_08330 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GJU35_08345 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GJU35_08350 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GJU35_08375 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GJU35_08380 ENOG4105BZU Histidine kinase GJU35_08385 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GJU35_08390 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GJU35_08425 ENOG4105CUB amino acid GJU35_08455 ENOG4105CFM UPF0317 protein GJU35_08460 ENOG4105E7W lamb ycsf family protein GJU35_08465 ENOG4105P4J Allophanate hydrolase, subunit 1 GJU35_08475 ENOG41090WU lipolytic protein G-D-S-L family GJU35_08480 ENOG4108MJN Glycosyl Transferase GJU35_08495 ENOG4105JXB ankyrin repeat-containing protein GJU35_08510 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GJU35_08515 ENOG4108VW9 Membrane GJU35_08525 ENOG4105DEU major facilitator superfamily GJU35_08530 ENOG4105Q70 GJU35_08540 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GJU35_08550 ENOG4105EW9 transcriptional regulator AsnC family GJU35_08560 ENOG4105C1G acyl-Coa dehydrogenase GJU35_08610 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GJU35_08615 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase GJU35_08620 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GJU35_08625 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GJU35_08640 ENOG4105E2R ROK family GJU35_08650 ENOG4105C2W permease GJU35_08655 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) GJU35_08695 ENOG4105CUB amino acid GJU35_08730 ENOG4105DKT Transcriptional regulator GJU35_08735 ENOG4105DJV ribulose-phosphate 3-epimerase GJU35_08740 ENOG4105EYF MMPL domain protein GJU35_08750 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GJU35_08765 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GJU35_08775 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GJU35_08780 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GJU35_08790 ENOG4105SKN orotidine 5''-phosphate decarboxylase GJU35_08795 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) GJU35_08800 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GJU35_08805 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GJU35_08815 ENOG4105CD3 dihydroorotase GJU35_08820 ENOG4105CXT aspartate transcarbamylase GJU35_08825 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GJU35_08835 ENOG410803B Involved in the transcription termination process (By similarity) GJU35_08840 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GJU35_08845 ENOG4105DC7 peptidase M24 GJU35_08855 ENOG4105D49 3-dehydroquinate synthase GJU35_08860 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GJU35_08865 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GJU35_08870 ENOG4105E2X shikimate dehydrogenase GJU35_08885 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GJU35_08890 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GJU35_08910 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GJU35_08925 ENOG4105CJ1 ABC, transporter GJU35_08935 ENOG4105BZU Histidine kinase GJU35_08940 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_08945 ENOG4105CUT histidyl-tRNA synthetase GJU35_08955 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) GJU35_08960 ENOG4105C99 atpase involved in dna repair GJU35_08965 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GJU35_08975 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GJU35_08980 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GJU35_08985 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GJU35_08995 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GJU35_09000 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GJU35_09005 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GJU35_09010 ENOG4105CDY transcriptional regulatory protein GJU35_09015 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GJU35_09020 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GJU35_09030 ENOG4105E2K Glycosyl transferase (Group 1 GJU35_09035 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase GJU35_09060 ENOG4105C22 threonyL-tRNA synthetase GJU35_09075 ENOG4108IRC dna polymerase iii GJU35_09095 ENOG4105EKC GJU35_09105 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GJU35_09110 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GJU35_09115 ENOG410769Z extracellular solute-binding protein family 1 GJU35_09130 ENOG4105KF0 sporulation and cell division protein, SsgA GJU35_09160 ENOG4105CRQ synthase (Component I) GJU35_09220 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GJU35_09225 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GJU35_09240 ENOG4105D01 (LipO)protein GJU35_09245 ENOG4108UMI ABC transporter, permease GJU35_09250 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GJU35_09275 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GJU35_09280 ENOG4105CEY Amp-dependent synthetase and ligase GJU35_09285 ENOG4106F60 Histidine kinase GJU35_09290 ENOG4105F44 Two component transcriptional regulator, winged helix family GJU35_09300 ENOG4107QVM von Willebrand factor, type A GJU35_09310 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GJU35_09315 ENOG4105C57 major facilitator superfamily GJU35_09320 ENOG4105RJZ Transcriptional regulator GJU35_09330 ENOG4105CH7 arginosuccinase GJU35_09365 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GJU35_09370 ENOG4105C8Y Acetylornithine aminotransferase GJU35_09375 ENOG4105CAS nag kinase GJU35_09380 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GJU35_09385 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GJU35_09390 ENOG4105E0A ABC, transporter GJU35_09395 ENOG4105CC5 ABC transporter GJU35_09420 ENOG41086D8 Transcriptional regulator GJU35_09450 ENOG4105T38 integral membrane protein GJU35_09460 ENOG4105F32 YngK protein GJU35_09490 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GJU35_09495 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GJU35_09500 ENOG4105BZU Histidine kinase GJU35_09505 ENOG4108RWN rrna methyltransferase GJU35_09510 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GJU35_09515 ENOG41084BS 50S ribosomal protein L35 GJU35_09520 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GJU35_09570 ENOG4105C26 Dehydrogenase GJU35_09575 ENOG4105C5F glutamine synthetase GJU35_09585 ENOG4108Z86 Glutamine amidotransferase GJU35_09610 ENOG4108HQS Glycine betaine GJU35_09620 ENOG4105HFS 5'-3' exonuclease GJU35_09650 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GJU35_09685 ENOG4105JZI cytochrome P450 GJU35_09695 ENOG4105C34 Pseudouridine synthase GJU35_09755 ENOG4108UQS dipeptidase GJU35_09760 ENOG4105CPF Cell wall formation (By similarity) GJU35_09780 ENOG4106F60 Histidine kinase GJU35_09785 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GJU35_09790 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GJU35_09820 ENOG4108V1T peptidylprolyl cis-trans isomerase GJU35_09825 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) GJU35_09835 ENOG4105ETE Transcriptional regulator (LacI family GJU35_09840 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GJU35_09845 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GJU35_09855 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) GJU35_09860 ENOG4105E5F proteasome GJU35_09865 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) GJU35_09900 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_09910 ENOG4108J59 Extracellular solute-binding protein, family 5 GJU35_09915 ENOG4107URF beta-phospho-glucomutase GJU35_09920 ENOG4105C3R Methionine synthase GJU35_09925 ENOG4108K8U Glycerol operon regulatory protein GJU35_09930 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GJU35_09935 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GJU35_09940 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GJU35_09945 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) GJU35_09955 ENOG4105C2J ABC transporter GJU35_09965 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GJU35_09970 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) GJU35_09975 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) GJU35_09980 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GJU35_09990 ENOG4105JXH GntR family transcriptional regulator GJU35_10005 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin GJU35_10015 ENOG4105C8N cysteinyl-tRNA synthetase GJU35_10030 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GJU35_10035 ENOG4105D7N magnesium and cobalt transport protein CorA GJU35_10045 ENOG4105DYW oxidoreductase GJU35_10050 ENOG4105CPC Aldo Keto reductase GJU35_10070 ENOG4105S2J secreted protein GJU35_10080 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GJU35_10095 ENOG4105CD8 aminopeptidase N GJU35_10100 ENOG4105K5B UPF0225 protein GJU35_10105 ENOG4105C6F GntR Family Transcriptional Regulator GJU35_10110 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GJU35_10115 ENOG4105C6Z Gluconate GJU35_10120 ENOG4105CHR reductase GJU35_10125 ENOG4105CPQ Dehydrogenase GJU35_10165 ENOG4105PTV Nudix Hydrolase GJU35_10170 ENOG4105VG5 Membrane GJU35_10195 ENOG4108IG5 Transcriptional regulator GJU35_10200 ENOG4105CEY Amp-dependent synthetase and ligase GJU35_10210 ENOG4105EHZ conserved protein UCP016719 GJU35_10245 ENOG4108Z4X TRANSCRIPTIONal GJU35_10265 ENOG4105C1G acyl-Coa dehydrogenase GJU35_10275 ENOG4108ZHR arsR family transcriptional regulator GJU35_10285 ENOG4105CSH Transporter GJU35_10315 ENOG4105D4T Citrate transporter GJU35_10320 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GJU35_10335 ENOG4108SGK Tetr family transcriptional regulator GJU35_10345 ENOG4105F1J Homogentisate 1,2-dioxygenase GJU35_10380 ENOG4105RNG membrane GJU35_10385 ENOG4105K6V RNA polymerase GJU35_10400 ENOG41061MD high-affinity nickel-transporter GJU35_10405 ENOG4105D9P serine threonine protein kinase GJU35_10410 ENOG4108TCJ secreted hydrolase GJU35_10415 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin GJU35_10435 ENOG4105K64 Glycosyl transferase, family 2 GJU35_10440 ENOG4107BJW polysaccharide deacetylase GJU35_10465 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GJU35_10515 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GJU35_10520 ENOG4105C0B DNA polymerase III (alpha subunit) GJU35_10540 ENOG4106NMR serine protease GJU35_10565 ENOG4105EAB amino acid AbC transporter GJU35_10575 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GJU35_10580 ENOG4105C1G acyl-Coa dehydrogenase GJU35_10585 ENOG4105C57 major facilitator superfamily GJU35_10595 ENOG410841Q phosphoesterase PA-phosphatase related protein GJU35_10635 ENOG4105C2J ABC transporter GJU35_10640 ENOG4108IV0 ABC, transporter GJU35_10645 ENOG4105MS9 Resuscitation-promoting factor GJU35_10660 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GJU35_10670 ENOG4105CAT Cytidine monophosphate kinase GJU35_10700 ENOG41065RQ ADP-ribosylation crystallin J1 GJU35_10725 ENOG4105FE9 pseudouridine synthase GJU35_10730 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GJU35_10735 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GJU35_10750 ENOG4105DCF alanine dehydrogenase GJU35_10760 ENOG4108YZ4 nudix hydrolase GJU35_10765 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GJU35_10770 ENOG4105BZP glycoside hydrolase 15-related GJU35_10785 ENOG4108MJN Glycosyl Transferase GJU35_10790 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GJU35_10795 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GJU35_10815 ENOG4105E0A ABC, transporter GJU35_10820 ENOG4105TVJ transport system, permease GJU35_10825 ENOG4105DQ5 transport system permease protein GJU35_10835 ENOG4105DSU hydrolase GJU35_10865 ENOG4108VX5 3-methyladenine DNA glycosylase GJU35_10875 ENOG4108V1U phospholipid-binding protein GJU35_10895 ENOG4105DKW ABC transporter GJU35_10915 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_10925 ENOG4105CAN Short-chain dehydrogenase reductase Sdr GJU35_10930 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GJU35_10940 ENOG4105IDI abc transporter atp-binding protein GJU35_10950 ENOG4105EAC phosphoserine phosphatase GJU35_10970 ENOG4107YCY Transcriptional regulator GJU35_10985 ENOG4105CHR reductase GJU35_10990 ENOG4105D1U peptidase U62 modulator of DNA gyrase GJU35_11000 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GJU35_11020 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GJU35_11025 ENOG4107QN1 sodium solute GJU35_11045 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F GJU35_11055 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GJU35_11070 ENOG4105BZP glycoside hydrolase 15-related GJU35_11100 ENOG4105VBF alkaline shock protein GJU35_11110 ENOG41060WC Enoyl-CoA hydratase GJU35_11120 ENOG4105C5H ABC transporter GJU35_11140 ENOG4107W7X Aldolase GJU35_11160 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GJU35_11165 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GJU35_11170 ENOG4105CTK cobaltochelatase, cobn subunit GJU35_11180 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GJU35_11185 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GJU35_11200 ENOG4105CIA precorrin-4 C(11)-methyltransferase GJU35_11210 ENOG4105E4R Precorrin-3B C17-methyltransferase GJU35_11215 ENOG41081F0 Precorrin-8x methylmutase GJU35_11220 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GJU35_11245 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GJU35_11255 ENOG4105EAD ABC transporter GJU35_11260 ENOG4106PMH Extracellular solute-binding protein family 3 GJU35_11265 ENOG4105C5R Aminotransferase GJU35_11270 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase GJU35_11275 ENOG4108JPW Aminotransferase GJU35_11280 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) GJU35_11285 ENOG4105EV8 ectoine hydroxylase GJU35_11295 ENOG4105K6V RNA polymerase GJU35_11300 ENOG4105C9B Cysteine desulfurase GJU35_11310 ENOG4105ECQ AraC Family Transcriptional Regulator GJU35_11330 ENOG4107258 Transcriptional regulator GJU35_11340 ENOG4105BZU Histidine kinase GJU35_11345 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_11355 ENOG4105C7N Xanthine uracil vitamin C permease GJU35_11360 ENOG4105NAF rna polymerase sigma factor GJU35_11390 ENOG4108J21 pectate lyase GJU35_11405 ENOG4105NBR Pectinesterase GJU35_11410 ENOG4105NBR Pectinesterase GJU35_11420 ENOG4107TDE lipolytic protein G-D-S-L family GJU35_11450 ENOG4108J20 pectate lyase GJU35_11465 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GJU35_11475 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase GJU35_11480 ENOG4105DRR Transcriptional regulator, GntR family GJU35_11510 ENOG4105E9Z Nad-dependent epimerase dehydratase GJU35_11515 ENOG4105E98 transcriptional regulator DeoR family GJU35_11535 ENOG4105CPQ Dehydrogenase GJU35_11560 ENOG4105DRS transport system, permease GJU35_11575 ENOG4105ETE Transcriptional regulator (LacI family GJU35_11585 ENOG4107XBN GntR Family Transcriptional Regulator GJU35_11640 ENOG4107S2Z UPF0761 membrane protein GJU35_11660 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GJU35_11670 ENOG4105NAF rna polymerase sigma factor GJU35_11680 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) GJU35_11685 ENOG4108RFG Tetr family transcriptional regulator GJU35_11690 ENOG410814C multidrug resistance protein GJU35_11700 ENOG4105VG1 fes assembly suf system protein GJU35_11705 ENOG4108UNV SUF system FeS assembly protein, NifU family GJU35_11710 ENOG4105C9B Cysteine desulfurase GJU35_11715 ENOG4105C3K feS assembly ATPase SufC GJU35_11725 ENOG4105JRK feS assembly protein SufD GJU35_11740 ENOG4108AQF aminoglycoside N(3)-acetyltransferase GJU35_11780 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GJU35_11790 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GJU35_11805 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) GJU35_11810 ENOG4107QP8 phosphohexose isomerase GJU35_11830 ENOG4105CP7 Triose-phosphate isomerase GJU35_11835 ENOG4105BZA Phosphoglycerate kinase GJU35_11840 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GJU35_11850 ENOG4105CIE May be required for sporulation (By similarity) GJU35_11855 ENOG4105CHW UPF0052 protein GJU35_11860 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GJU35_11865 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GJU35_11870 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_11875 ENOG4105BZU Histidine kinase GJU35_11885 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_11905 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GJU35_11920 ENOG4107R0W ABC transporter GJU35_11925 ENOG4105E5Q amino acid AbC transporter GJU35_11935 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GJU35_11940 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GJU35_11945 ENOG4105CSH Transporter GJU35_11975 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GJU35_11980 ENOG4105BZU Histidine kinase GJU35_11985 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GJU35_11990 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GJU35_11995 ENOG4105E2A Dehydrogenase GJU35_12005 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) GJU35_12010 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) GJU35_12015 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GJU35_12020 ENOG4105D7N magnesium and cobalt transport protein CorA GJU35_12050 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GJU35_12055 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GJU35_12095 ENOG4105BZ1 (ABC) transporter GJU35_12110 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GJU35_12150 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GJU35_12155 ENOG4105DRR Transcriptional regulator, GntR family GJU35_12195 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GJU35_12210 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GJU35_12215 ENOG4105CQ7 ATP-dependent helicase GJU35_12250 ENOG4105KA0 thioesterase Superfamily protein GJU35_12265 ENOG4105C32 Amino acid ABC transporter (Permease) GJU35_12270 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GJU35_12275 ENOG4105C0Z ABC transporter GJU35_12280 ENOG4108IV0 ABC, transporter GJU35_12310 ENOG4105CGH 5'-nucleotidase GJU35_12330 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GJU35_12335 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GJU35_12355 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GJU35_12365 ENOG4105E39 Enoyl-CoA hydratase GJU35_12380 ENOG4105EA8 2-Nitropropane dioxygenase GJU35_12385 ENOG4105F2C Acetyl-CoA acetyltransferase GJU35_12390 ENOG4108RZE Tetr family transcriptional regulator GJU35_12395 ENOG4105CHR reductase GJU35_12400 ENOG4105D2B acyl-CoA dehydrogenase GJU35_12405 ENOG4105C1G acyl-Coa dehydrogenase GJU35_12410 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GJU35_12415 ENOG4105MUA Resistance protein GJU35_12425 ENOG4105CBC glutamate synthase GJU35_12455 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GJU35_12460 ENOG4105CI0 Citrate lyase GJU35_12465 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GJU35_12475 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GJU35_12480 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GJU35_12485 ENOG4105DK0 Indole-3-glycerol phosphate synthase GJU35_12505 ENOG4105CRQ synthase (Component I) GJU35_12510 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GJU35_12530 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GJU35_12535 ENOG4108176 endoribonuclease L-psp GJU35_12540 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GJU35_12545 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GJU35_12550 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GJU35_12555 ENOG4105CIH Imidazole acetol-phosphate transaminase GJU35_12560 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GJU35_12580 ENOG4108Z66 YbaK ebsC protein GJU35_12605 ENOG4105C0B DNA polymerase III (alpha subunit) GJU35_12640 ENOG4105CHR reductase GJU35_12660 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GJU35_12675 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GJU35_12680 ENOG4107VQS DivIVA family GJU35_12690 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GJU35_12695 ENOG4105DFA alanine racemase domain protein GJU35_12700 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GJU35_12705 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GJU35_12710 ENOG4105ME9 cell division protein FtsQ GJU35_12715 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GJU35_12725 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GJU35_12730 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GJU35_12740 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GJU35_12745 ENOG4105CJN penicillin-binding protein GJU35_12755 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GJU35_12765 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GJU35_12785 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GJU35_12795 ENOG4107T0D ABC, transporter GJU35_12805 ENOG4107Z3H Transcriptional regulator, TetR family GJU35_12825 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GJU35_12855 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GJU35_12865 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GJU35_12875 ENOG4108UQY Iron-storage protein GJU35_12885 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase GJU35_12900 ENOG4105CTQ phosphohexokinase GJU35_12910 ENOG4105ENE Histidine kinase GJU35_12935 ENOG4105DKQ ROK family GJU35_12945 ENOG4105D0U Arsenite-activated ATPase (ArsA) GJU35_12960 ENOG4108IQE Amp-dependent synthetase and ligase GJU35_13020 ENOG4105GR3 Histidine kinase GJU35_13025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GJU35_13035 ENOG4105BZW Glycerate kinase GJU35_13040 ENOG4105C9B Cysteine desulfurase GJU35_13045 ENOG4108I0Q anthranilate phosphoribosyltransferase GJU35_13050 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GJU35_13055 ENOG4107EUI c reductase, iron-sulfur GJU35_13060 ENOG4107UDY cytochrome C GJU35_13065 ENOG4105CCU oxidase (Subunit III) GJU35_13075 ENOG4107UBC ErfK ybiS ycfS ynhG family protein GJU35_13080 ENOG4105MCD Part of cytochrome c oxidase, its function is GJU35_13085 ENOG4105BZ9 Cytochrome C oxidase, subunit I GJU35_13090 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) GJU35_13100 ENOG4107T4Z adenosine kinase GJU35_13125 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GJU35_13130 ENOG4108762 serine threonine protein kinase GJU35_13140 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_13145 ENOG4105BZU Histidine kinase GJU35_13185 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GJU35_13200 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GJU35_13230 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GJU35_13255 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GJU35_13295 ENOG4105ECP epimerase GJU35_13310 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GJU35_13315 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GJU35_13335 ENOG4105C5F glutamine synthetase GJU35_13345 ENOG4105D0M Protease HtpX homolog GJU35_13375 ENOG4108222 arsenate reductase GJU35_13380 ENOG4106SPC secreted protein GJU35_13385 ENOG4107R5B glutamine synthetase GJU35_13395 ENOG4107NHD transcriptional regulator GJU35_13405 ENOG4108XG2 Histidine kinase GJU35_13410 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_13435 ENOG41060BG Tetr family transcriptional regulator GJU35_13470 ENOG4105CG3 alpha amylase, catalytic region GJU35_13475 ENOG4105EG2 ABC transporter, permease GJU35_13490 ENOG4105ETE Transcriptional regulator (LacI family GJU35_13500 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GJU35_13525 ENOG4105C5F glutamine synthetase GJU35_13550 ENOG4105C4K Nad synthetase GJU35_13555 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GJU35_13585 ENOG4108JGH Tetr family transcriptional regulator GJU35_13590 ENOG4105C57 major facilitator superfamily GJU35_13595 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GJU35_13620 ENOG4107XZ0 Peptidase M50 GJU35_13665 ENOG4105EHG Permease protein GJU35_13670 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GJU35_13680 ENOG4105DBE peroxidase GJU35_13690 ENOG4106A0S GJU35_13700 ENOG4107T6V glycerophosphoryl diester phosphodiesterase GJU35_13715 ENOG4107S1E Beta-lactamase GJU35_13720 ENOG4105C2C drug resistance transporter, Bcr CflA GJU35_13730 ENOG4105DGI Alkaline phosphatase GJU35_13750 ENOG4108VGI doxx family GJU35_13770 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GJU35_13775 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GJU35_13850 ENOG4105E7U AraC family transcriptional regulator GJU35_13865 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GJU35_13870 ENOG4107XFJ UPF0246 protein GJU35_13875 ENOG4108UHU Aldolase GJU35_13890 ENOG4105EGD dinuclear metal center protein, YbgI family GJU35_13900 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr GJU35_13915 ENOG4105BZU Histidine kinase GJU35_13920 ENOG4108S01 response regulator GJU35_13930 ENOG4105C0R drug resistance transporter emrb qaca subfamily GJU35_13940 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase GJU35_13950 ENOG4105DYW oxidoreductase GJU35_13980 ENOG4107QVI Methyltransferase, type 11 GJU35_13985 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GJU35_13990 ENOG4108SGK Tetr family transcriptional regulator GJU35_14030 ENOG4108JJB ABC transporter GJU35_14045 ENOG4105XPP Protein of unknown function (DUF1275) GJU35_14060 ENOG4105MHT Transcriptional regulator, ARSR family GJU35_14085 ENOG4105F2C Acetyl-CoA acetyltransferase GJU35_14090 ENOG4106A3M Cytochrome p-450 GJU35_14180 ENOG4105NQG DoxX GJU35_14205 ENOG4105F27 Major Facilitator GJU35_14265 ENOG4107T5V SNARE associated Golgi GJU35_14275 ENOG4105DAX Pfam:DUF2983 GJU35_14320 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GJU35_14325 ENOG4105EYW Ion transport protein GJU35_14360 ENOG4105CPC Aldo Keto reductase GJU35_14365 ENOG4105VUF Transcriptional regulator GJU35_14400 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GJU35_14420 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GJU35_14425 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GJU35_14440 ENOG4105C5Q Transcriptional regulator GJU35_14445 ENOG4105NGS secreted protein GJU35_14470 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GJU35_14490 ENOG4105CXK mandelate racemase muconate lactonizing GJU35_14510 ENOG4105C2J ABC transporter GJU35_14515 ENOG4108HWW ABC transporter GJU35_14520 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GJU35_14530 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) GJU35_14535 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase GJU35_14600 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase GJU35_14605 ENOG4105DRS transport system, permease GJU35_14610 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GJU35_14640 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein GJU35_14645 ENOG4105J4Q Transcriptional regulator GJU35_14675 ENOG41073B4 coagulation factor 5 8 type domain-containing protein GJU35_14720 ENOG4105C6F GntR Family Transcriptional Regulator GJU35_14730 ENOG4105CEY Amp-dependent synthetase and ligase GJU35_14735 ENOG4105D8K carboxyl transferase GJU35_14750 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GJU35_14755 ENOG4106PBJ Serine threonine-protein kinase Pkn6 GJU35_14760 ENOG4105DFF Rod shape-determining protein mreb GJU35_14830 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GJU35_14855 ENOG4105D9P serine threonine protein kinase GJU35_14885 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_14890 ENOG4105BZU Histidine kinase GJU35_14910 ENOG4108UZX fmn reductase GJU35_14930 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) GJU35_14940 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component GJU35_14960 ENOG4105ETX regulatoR GJU35_14965 ENOG41062D9 Histidine kinase GJU35_14970 ENOG4105EYF MMPL domain protein GJU35_15030 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GJU35_15035 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GJU35_15045 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GJU35_15055 ENOG4107GZ4 SanA protein GJU35_15065 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GJU35_15110 ENOG4105KVH Transcriptional regulator GJU35_15135 ENOG4107QZF nitrite reductase NADPH large subunit GJU35_15145 ENOG4105M4P Tetr family transcriptional regulator GJU35_15150 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GJU35_15155 ENOG410829K Lysine exporter protein (Lyse ygga) GJU35_15165 ENOG4105CHH sulfate transporter GJU35_15170 ENOG4107B2H carbonic anhydrase GJU35_15175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GJU35_15200 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GJU35_15205 ENOG4105E2R ROK family GJU35_15235 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GJU35_15260 ENOG4108FN7 Aldo keto reductase GJU35_15265 ENOG410829K Lysine exporter protein (Lyse ygga) GJU35_15270 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GJU35_15275 ENOG4105DSE periplasmic solute binding protein GJU35_15280 ENOG4105FDK ABC transporter GJU35_15285 ENOG4105FAV ABC, transporter GJU35_15295 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GJU35_15300 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) GJU35_15345 ENOG4105NAF rna polymerase sigma factor GJU35_15365 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GJU35_15380 ENOG4105BZU Histidine kinase GJU35_15385 ENOG4105EYF MMPL domain protein GJU35_15395 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GJU35_15400 ENOG4105D4Y metalloprotease GJU35_15430 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GJU35_15455 ENOG4105MSB protein, conserved in bacteria GJU35_15465 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GJU35_15480 ENOG4105EQX glucarate dehydratase GJU35_15485 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase GJU35_15490 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region GJU35_15500 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GJU35_15505 ENOG4107YU2 histidine triad (hIT) protein GJU35_15510 ENOG4107RE3 peptidase, S41 GJU35_15535 ENOG4107QWG 2-Nitropropane dioxygenase GJU35_15540 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GJU35_15545 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GJU35_15570 ENOG4105BZU Histidine kinase GJU35_15575 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GJU35_15585 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GJU35_15590 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GJU35_15615 ENOG4108YYC ycei family GJU35_15620 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GJU35_15625 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GJU35_15630 ENOG4105KQC Competence protein GJU35_15635 ENOG4105EPR degv family GJU35_15645 ENOG4105C8T Leucyl-tRNA synthetase GJU35_15655 ENOG4107QIZ NADH dehydrogenase GJU35_15690 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GJU35_15695 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GJU35_15705 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GJU35_15715 ENOG4105D0M Protease HtpX homolog GJU35_15730 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GJU35_15740 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GJU35_15765 ENOG4105DGI Alkaline phosphatase GJU35_15775 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GJU35_15780 ENOG4105K46 50S ribosomal protein l27 GJU35_15785 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GJU35_15790 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase GJU35_15800 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase GJU35_15810 ENOG4107V9E glucose-1-phosphate thymidylyltransferase GJU35_15815 ENOG4105C03 ribonuclease GJU35_15835 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GJU35_15840 ENOG4105CFC Transporter GJU35_15880 ENOG4105CNI cell division protein FtsW GJU35_15885 ENOG4105CJN penicillin-binding protein GJU35_15900 ENOG4105DFF Rod shape-determining protein mreb GJU35_15905 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GJU35_15915 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GJU35_15920 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GJU35_15930 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GJU35_15935 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GJU35_15940 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GJU35_15945 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GJU35_15965 ENOG4108TGC Acyltransferase GJU35_15980 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GJU35_16000 ENOG4108YZG isomerase GJU35_16005 ENOG4105C85 amino acid GJU35_16010 ENOG4108UGD Serine Threonine protein kinase GJU35_16030 ENOG4105C85 amino acid GJU35_16040 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GJU35_16050 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GJU35_16055 ENOG4105CMG Carbohydrate kinase GJU35_16080 ENOG4105MC2 DSBA oxidoreductase GJU35_16170 ENOG4108ZT1 Transcriptional regulator GJU35_16175 ENOG4107SCK Monooxygenase GJU35_16210 ENOG4105CJ1 ABC, transporter GJU35_16230 ENOG4105D8X mechanosensitive ion channel GJU35_16250 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GJU35_16255 ENOG4105F8D glycoside hydrolase family 4 GJU35_16270 ENOG4106PMH Extracellular solute-binding protein family 3 GJU35_16300 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GJU35_16320 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GJU35_16355 ENOG4105VEQ Cold shock protein GJU35_16370 ENOG4105VHU single-stranded DNA-binding protein GJU35_16430 ENOG4105C5I Dehydrogenase GJU35_16485 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GJU35_16500 ENOG4105CJR Integral membrane protein (MviN GJU35_16510 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GJU35_16535 ENOG4105S2J secreted protein GJU35_16570 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids GJU35_16595 ENOG4105C26 Dehydrogenase GJU35_16600 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GJU35_16605 ENOG4105DH8 myo-inositol catabolism GJU35_16615 ENOG4105EDK PfkB domain protein GJU35_16620 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) GJU35_16645 ENOG4105C7H Helicase, RecD TraA family GJU35_16660 ENOG4105ETE Transcriptional regulator (LacI family GJU35_16665 ENOG4105C2J ABC transporter GJU35_16670 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GJU35_16675 ENOG4108RVA ribokinase GJU35_16680 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GJU35_16705 ENOG4105ETE Transcriptional regulator (LacI family GJU35_16735 ENOG410645S MarR family Transcriptional regulator GJU35_16755 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GJU35_16760 ENOG4105D17 glycoside hydrolase, family 3 domain protein GJU35_16795 ENOG4105EDW glycosyl transferase, family 39 GJU35_16800 ENOG4108K8S endonuclease I GJU35_16805 ENOG4105C7K acetolactate synthase GJU35_16825 ENOG4108XFF GJU35_16830 ENOG4105C29 acyl-CoA thioesterase GJU35_16845 ENOG4107QX3 carboxylase GJU35_16855 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GJU35_16860 ENOG4105C1G acyl-Coa dehydrogenase GJU35_16880 ENOG4105ESF Peptidoglycan binding domain protein GJU35_16910 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) GJU35_16940 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GJU35_16960 ENOG4105ECQ AraC Family Transcriptional Regulator GJU35_16965 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GJU35_16985 ENOG4105ETE Transcriptional regulator (LacI family GJU35_17000 ENOG4105DRS transport system, permease GJU35_17010 ENOG4105BZU Histidine kinase GJU35_17040 ENOG4108ZM9 phosphoglycerate mutase GJU35_17085 ENOG4105BZU Histidine kinase GJU35_17090 ENOG4105DEN Luciferase family GJU35_17110 ENOG4105DV0 amidase (EC 3.5.1.4 GJU35_17150 ENOG4105J5T Amp-dependent synthetase and ligase GJU35_17160 ENOG4108M1A Chitin-binding protein GJU35_17180 ENOG4105JXH GntR family transcriptional regulator GJU35_17195 ENOG4105EMN RNA polymerase sigma factor GJU35_17215 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GJU35_17235 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GJU35_17240 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GJU35_17245 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GJU35_17260 ENOG4108HQS Glycine betaine GJU35_17265 ENOG4108IJ7 Glycine betaine GJU35_17305 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GJU35_17325 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GJU35_17350 ENOG4105D9P serine threonine protein kinase GJU35_17370 ENOG4105DC1 bifunctional purine biosynthesis protein purh GJU35_17400 ENOG4105CMV Succinyl-CoA synthetase subunit beta GJU35_17415 ENOG4105DEG Vwa containing coxe family protein GJU35_17425 ENOG4105RD5 GJU35_17430 ENOG4105KKX ATPase associated with various cellular activities aaa_5 GJU35_17455 ENOG4105DR5 peptidase GJU35_17480 ENOG4105K4H Nlp p60 protein GJU35_17485 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_17525 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GJU35_17555 ENOG4105C26 Dehydrogenase GJU35_17560 ENOG4108UGD Serine Threonine protein kinase GJU35_17565 ENOG4107TPY serine threonine protein kinase GJU35_17570 ENOG4108UGD Serine Threonine protein kinase GJU35_17575 ENOG4107TPY serine threonine protein kinase GJU35_17580 ENOG4105D9P serine threonine protein kinase GJU35_17595 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GJU35_17600 ENOG4107QQG Dehydrogenase GJU35_17610 ENOG4107QVP Dehydrogenase GJU35_17620 ENOG4108MMM RNA Polymerase GJU35_17630 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GJU35_17635 ENOG4105DND Transcriptional regulator GJU35_17645 ENOG4105EMU Dehydrogenase GJU35_17655 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GJU35_17660 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GJU35_17680 ENOG4105CHP RNA polymerase GJU35_17705 ENOG4105ETE Transcriptional regulator (LacI family GJU35_17710 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GJU35_17725 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GJU35_17745 ENOG4108097 ATP-binding protein GJU35_17750 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 GJU35_17755 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GJU35_17780 ENOG4108YUY GJU35_17795 ENOG41064E2 Xylose isomerase-like TIM barrel GJU35_17800 ENOG4107VXZ Hydrolase GJU35_17815 ENOG4105EQ2 LysR family Transcriptional regulator GJU35_17835 ENOG4105F27 Major Facilitator GJU35_17840 ENOG4108Z6Z Transcriptional regulator GJU35_17905 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GJU35_17910 ENOG4105CS9 pantothenic acid kinase GJU35_17920 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GJU35_17925 ENOG4108UJD 30S ribosomal protein S9 GJU35_17930 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GJU35_17945 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GJU35_17950 ENOG4108ZT0 50S ribosomal protein l17 GJU35_17955 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GJU35_17960 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GJU35_17965 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GJU35_17970 ENOG41067V7 50S ribosomal protein L36 GJU35_17975 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GJU35_17985 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GJU35_17995 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GJU35_18000 ENOG410849U 50S ribosomal protein L30 GJU35_18005 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GJU35_18010 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GJU35_18015 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GJU35_18020 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GJU35_18030 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GJU35_18035 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GJU35_18040 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GJU35_18045 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GJU35_18050 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GJU35_18055 ENOG41082SA 50s ribosomal protein l29 GJU35_18060 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GJU35_18065 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GJU35_18070 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GJU35_18075 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GJU35_18080 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GJU35_18085 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GJU35_18090 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GJU35_18095 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GJU35_18100 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GJU35_18115 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GJU35_18120 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GJU35_18125 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GJU35_18130 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GJU35_18170 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GJU35_18175 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GJU35_18180 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GJU35_18185 ENOG4108VZM 50s ribosomal protein L10 GJU35_18190 ENOG4105QCJ Lipoprotein GJU35_18200 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GJU35_18205 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GJU35_18210 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GJU35_18230 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GJU35_18240 ENOG4107R4N Cell wall formation (By similarity) GJU35_18260 ENOG410900P UPF0336 protein GJU35_18265 ENOG4105WDJ 50S ribosomal protein L33 GJU35_18305 ENOG4108VPT UPF0234 protein GJU35_18310 ENOG4105Y3U Transglycosylase-associated protein GJU35_18325 ENOG410901E Membrane GJU35_18330 ENOG4105D0M Protease HtpX homolog GJU35_18335 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GJU35_18345 ENOG4105D65 subunit l GJU35_18350 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GJU35_18355 ENOG4107YX3 NADH dehydrogenase subunit j GJU35_18360 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GJU35_18365 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GJU35_18370 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GJU35_18375 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GJU35_18380 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GJU35_18400 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GJU35_18405 ENOG4105DQU oxidoreductase, subunit beta GJU35_18420 ENOG4105ECR NmrA family GJU35_18435 ENOG4105KVH Transcriptional regulator GJU35_18475 ENOG4105CJ1 ABC, transporter GJU35_18495 ENOG4105DUX Transporter GJU35_18505 ENOG4108FKH Transglycosylase SLT domain GJU35_18510 ENOG410667J hydrolase GJU35_18515 ENOG4105ETE Transcriptional regulator (LacI family GJU35_18520 ENOG4105DRS transport system, permease GJU35_18550 ENOG4105C9U ATP-dependent DNA helicase RecQ GJU35_18555 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GJU35_18565 ENOG4105D65 subunit l GJU35_18570 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GJU35_18575 ENOG41087XN oxidoreductase GJU35_18580 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GJU35_18585 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GJU35_18590 ENOG4108IEH NADH dehydrogenase subunit g GJU35_18595 ENOG4107QIZ NADH dehydrogenase GJU35_18605 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GJU35_18610 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GJU35_18615 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GJU35_18650 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GJU35_18655 ENOG4108NNZ chitinase GJU35_18665 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GJU35_18675 ENOG4108762 serine threonine protein kinase GJU35_18680 ENOG4105EV6 Pfam:DUF178 GJU35_18685 ENOG4105VEQ Cold shock protein GJU35_18690 ENOG4108IMY Transcriptional regulator GJU35_18710 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein GJU35_18755 ENOG4105CHR reductase GJU35_18765 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GJU35_18780 ENOG4108KPJ rna polymerase sigma factor GJU35_18790 ENOG4108UN4 phage SPO1 DNA polymerase-related protein GJU35_18795 ENOG4105DVY radical SAM domain protein GJU35_18805 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GJU35_18820 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GJU35_18830 ENOG4107V2S Transcriptional regulator GJU35_18845 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GJU35_18850 ENOG4108Z6Z Transcriptional regulator GJU35_18875 ENOG4105CRE cytochrome C GJU35_18880 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) GJU35_18885 ENOG4107QIV Cytochrome c biogenesis protein GJU35_18890 ENOG4107ZT5 Thiol disulfide interchange protein GJU35_18900 ENOG4108RH7 phosphoglycerate mutase GJU35_18905 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GJU35_18950 ENOG4105CSH Transporter GJU35_18995 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) GJU35_19050 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GJU35_19090 ENOG4108UZX fmn reductase GJU35_19095 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GJU35_19120 ENOG4105E0Y RtcB Protein GJU35_19140 ENOG4105DK7 lysyl-tRNA synthetase GJU35_19145 ENOG4105C75 arginyL-tRNA synthetase GJU35_19160 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GJU35_19175 ENOG4105D52 delta-aminolevulinic acid dehydratase GJU35_19185 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GJU35_19190 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GJU35_19195 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GJU35_19200 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GJU35_19245 ENOG4108XFF GJU35_19250 ENOG4105DGU Histone deacetylase GJU35_19265 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 GJU35_19285 ENOG4105C31 Tryptophanyl-tRNA synthetase GJU35_19290 ENOG4105II7 pyrroline-5-carboxylate reductase GJU35_19300 ENOG4105CJ1 ABC, transporter GJU35_19315 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein GJU35_19325 ENOG4105C01 Dihydroxy-acid dehydratase GJU35_19330 ENOG4105XEA Tetr family transcriptional regulator GJU35_19335 ENOG4105EY0 Xylose isomerase domain protein TIM barrel GJU35_19340 ENOG4105CWX Alpha-1,2-mannosidase GJU35_19345 ENOG4107R33 ppx gppa phosphatase GJU35_19350 ENOG4108JWX GJU35_19365 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) GJU35_19385 ENOG4105BZU Histidine kinase GJU35_19390 ENOG4105CEN a g-specific adenine glycosylase GJU35_19395 ENOG4105NAF rna polymerase sigma factor GJU35_19400 ENOG41075QH Lipoprotein CseA GJU35_19405 ENOG4108PYU two-component system response regulator GJU35_19410 ENOG4108FKE two-component system sensor kinase GJU35_19425 ENOG4105C0R drug resistance transporter emrb qaca subfamily GJU35_19430 ENOG4108IG5 Transcriptional regulator GJU35_19435 ENOG4105DR5 peptidase GJU35_19495 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) GJU35_19505 ENOG4108IYU L-aspartate oxidase GJU35_19510 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GJU35_19520 ENOG4105C5W Aldolase GJU35_19535 ENOG4105I1F Resistance protein GJU35_19555 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GJU35_19580 ENOG4105CRK lysyL-tRNA synthetase GJU35_19600 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GJU35_19610 ENOG4105EUJ GTP cyclohydrolase i GJU35_19620 ENOG4108UGV hypoxanthine phosphoribosyltransferase GJU35_19625 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GJU35_19640 ENOG4105F0N pyrophosphate phospho-hydrolase GJU35_19650 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN GJU35_19660 ENOG4107TXC Transcriptional regulator GJU35_19665 ENOG4105CVK Glutamate decarboxylase GJU35_19690 ENOG4105C26 Dehydrogenase GJU35_19710 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GJU35_19720 ENOG4105NRA 50s ribosomal protein l31 type b GJU35_19725 ENOG4105W0E 50S ribosomal protein L33 GJU35_19730 ENOG4105KDC 50s ribosomal protein l28 GJU35_19735 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GJU35_19765 ENOG4105C2M dna polymerase I GJU35_19810 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_19840 ENOG4105KVH Transcriptional regulator GJU35_19855 ENOG4105R0I Feruloyl esterase GJU35_19925 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GJU35_19930 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GJU35_19955 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for GJU35_19960 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GJU35_19965 ENOG4105WN5 stage II sporulation protein GJU35_19970 ENOG4108I5C dEAD DEAH box helicase GJU35_20030 ENOG4107B2H carbonic anhydrase GJU35_20035 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GJU35_20040 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GJU35_20050 ENOG4105D74 hydrolase GJU35_20065 ENOG4105P8F nudix hydrolase GJU35_20080 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GJU35_20120 ENOG4105BZ4 penicillin-binding protein GJU35_20195 ENOG4108HMN Caspase domain GJU35_20215 ENOG4105D9P serine threonine protein kinase GJU35_20220 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF GJU35_20235 ENOG4108PJD permease GJU35_20265 ENOG4105NAF rna polymerase sigma factor GJU35_20275 ENOG4105CFH Aspartokinase GJU35_20280 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GJU35_20285 ENOG4105EB3 Histidine kinase GJU35_20345 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GJU35_20350 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GJU35_20375 ENOG4108V4B ThiJ pfpI GJU35_20380 ENOG4108JPW Aminotransferase GJU35_20385 ENOG4105DRR Transcriptional regulator, GntR family GJU35_20405 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic GJU35_20410 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GJU35_20420 ENOG4107FQ9 ethanolamine ammonia-lyase GJU35_20425 ENOG4105CPD ethanolamine ammonia-lyase GJU35_20455 ENOG4105CIG ABC transporter GJU35_20460 ENOG4105DIM ABC transporter GJU35_20475 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_20480 ENOG4105BZU Histidine kinase GJU35_20485 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_20490 ENOG4105BZU Histidine kinase GJU35_20510 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) GJU35_20530 ENOG4107RCW fructose-bisphosphate aldolase GJU35_20535 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GJU35_20550 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GJU35_20580 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GJU35_20620 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_20635 ENOG4105CJ1 ABC, transporter GJU35_20665 ENOG4105DFW ABC transporter GJU35_20695 ENOG4105KNI merR family transcriptional Regulator GJU35_20700 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GJU35_20705 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GJU35_20710 ENOG4105CFG Acts as a chaperone (By similarity) GJU35_20720 ENOG4105DF6 Fe-S oxidoreductase GJU35_20755 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) GJU35_20760 ENOG4105DHP deoxycytidine triphosphate deaminase GJU35_20840 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GJU35_20860 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GJU35_20865 ENOG4107S1E Beta-lactamase GJU35_20935 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GJU35_21005 ENOG4105D9P serine threonine protein kinase GJU35_21030 ENOG4105CVR type I restriction-modification system GJU35_21060 ENOG4105BZU Histidine kinase GJU35_21075 ENOG4105BZU Histidine kinase GJU35_21080 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_21095 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit GJU35_21100 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding GJU35_21105 ENOG4105C7W Xanthine dehydrogenase GJU35_21120 ENOG4105E1F short-chain dehydrogenase reductase GJU35_21160 ENOG41065SU Two-component system sensor kinase GJU35_21165 ENOG4108KXV response regulator GJU35_21180 ENOG4105FF0 ErfK YbiS YcfS YnhG GJU35_21245 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GJU35_21260 ENOG4105VEQ Cold shock protein GJU35_21265 ENOG4105C1J atp-dependent rna helicase GJU35_21290 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GJU35_21295 ENOG4105J7D transcriptional regulator GJU35_21305 ENOG4107T5V SNARE associated Golgi GJU35_21310 ENOG4105BZU Histidine kinase GJU35_21385 ENOG4108KPJ rna polymerase sigma factor GJU35_21390 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GJU35_21455 ENOG4105EMN RNA polymerase sigma factor GJU35_21470 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase GJU35_21485 ENOG4105CSH Transporter GJU35_21490 ENOG41061GT Aldolase GJU35_21495 ENOG4106M32 3-dehydroquinate synthase GJU35_21500 ENOG4105CEY Amp-dependent synthetase and ligase GJU35_21505 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GJU35_21545 ENOG4105CHR reductase GJU35_21550 ENOG4105DFW ABC transporter GJU35_21565 ENOG4105BZU Histidine kinase GJU35_21590 ENOG4105VEQ Cold shock protein GJU35_21645 ENOG4105CG3 alpha amylase, catalytic region GJU35_21705 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GJU35_21740 ENOG4105DU0 nucleoside hydrolase GJU35_21745 ENOG4105C22 threonyL-tRNA synthetase GJU35_21765 ENOG4108PJD permease GJU35_21800 ENOG4105CH2 amidohydrolase GJU35_21840 ENOG4107U9B transcriptional regulator GJU35_21845 ENOG4105F2Z 3-oxoadipate enol-lactonase GJU35_21855 ENOG410613R integral membrane protein, YccS YhfK family GJU35_21870 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GJU35_21900 ENOG4108J20 pectate lyase GJU35_21905 ENOG4105KWG Pfam:DUF1696 GJU35_21920 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GJU35_21945 ENOG4105C9M aspartyl-trna synthetase GJU35_21960 ENOG4105EUB pirin domain protein GJU35_21965 ENOG4105C57 major facilitator superfamily GJU35_21985 ENOG4105CSU acyl-Coa dehydrogenase GJU35_21990 ENOG4105DFM M18 family aminopeptidase GJU35_22005 ENOG4105ECQ AraC Family Transcriptional Regulator GJU35_22055 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 GJU35_22060 ENOG4105CPP Dehydrogenase, E1 component GJU35_22090 ENOG4107QPV Serine Threonine protein kinase GJU35_22120 ENOG4105EYW Ion transport protein GJU35_22125 ENOG4105CVM Molybdenum cofactor synthesis domain protein GJU35_22135 ENOG4107QSN dihydrolipoamide acetyltransferase GJU35_22155 ENOG4108IG5 Transcriptional regulator GJU35_22160 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GJU35_22170 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GJU35_22190 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GJU35_22205 ENOG4105KVH Transcriptional regulator GJU35_22210 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GJU35_22220 ENOG4105TV9 FHA Domain-Containing protein GJU35_22225 ENOG4105HZM Fha domain containing protein GJU35_22240 ENOG4105CJN penicillin-binding protein GJU35_22250 ENOG4108RN7 integral membrane protein GJU35_22255 ENOG4108U4N (sortase) family GJU35_22270 ENOG4108U4N (sortase) family GJU35_22280 ENOG4105ZJT Cell division protein CrgA GJU35_22340 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GJU35_22345 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GJU35_22350 ENOG4105K7N UPF0232 protein GJU35_22355 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GJU35_22360 ENOG4108J5G 6-phosphogluconate dehydrogenase GJU35_22365 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GJU35_22370 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GJU35_22380 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GJU35_22385 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GJU35_22390 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GJU35_22400 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GJU35_22405 ENOG4107QJE Chromosome Partitioning Protein GJU35_22420 ENOG4105K63 Thioredoxin GJU35_22425 ENOG4105C3M thioredoxin reductase GJU35_22440 ENOG4105D9P serine threonine protein kinase GJU35_22455 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GJU35_22475 ENOG4105BZ4 penicillin-binding protein GJU35_22505 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) GJU35_22510 ENOG4107YH6 single-stranded DNA-binding protein GJU35_22515 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GJU35_22520 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GJU35_22530 ENOG4105CDU Replicative dna helicase GJU35_22575 ENOG4105F27 Major Facilitator GJU35_22605 ENOG4105C28 cystathionine GJU35_22610 ENOG4105KJF protein tyrosine phosphatase GJU35_22615 ENOG41082T9 Membrane GJU35_22620 ENOG4106048 Cupin 2, conserved barrel domain protein GJU35_22645 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GJU35_22660 ENOG4107P2S Transcriptional regulator GJU35_22665 ENOG4105CIH Imidazole acetol-phosphate transaminase GJU35_22670 ENOG4105C4M (Ubiquinol oxidase) subunit I GJU35_22675 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GJU35_22680 ENOG4108JJ9 ABC, transporter GJU35_22695 ENOG410667J hydrolase GJU35_22710 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) GJU35_22715 ENOG4107SWG transcriptional regulator MERR family GJU35_22765 ENOG410667J hydrolase GJU35_22770 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GJU35_22775 ENOG4105CQC Prephenate dehydratase GJU35_22785 ENOG4105DBE peroxidase GJU35_22820 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase GJU35_22830 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GJU35_22835 ENOG4107T6F Xaa-Pro aminopeptidase GJU35_22855 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GJU35_22920 ENOG4105NAF rna polymerase sigma factor GJU35_22930 ENOG4105CEY Amp-dependent synthetase and ligase GJU35_23005 ENOG4108KPJ rna polymerase sigma factor GJU35_23010 ENOG4105ECP epimerase GJU35_23020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GJU35_23025 ENOG4105BZU Histidine kinase GJU35_23035 ENOG4105EDW glycosyl transferase, family 39 GJU35_23040 ENOG4105C57 major facilitator superfamily GJU35_23050 ENOG410905P Pyridoxamine 5-phosphate GJU35_23075 ENOG4108YYC ycei family GJU35_23080 ENOG4105C0R drug resistance transporter emrb qaca subfamily GJU35_23085 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GJU35_23095 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GJU35_23100 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GJU35_23105 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein GJU35_23135 ENOG4108Z6B deaminase GJU35_23150 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GJU35_23205 ENOG4105CHR reductase GJU35_23210 ENOG4108T5E Copper resistance protein GJU35_23230 ENOG4105BZU Histidine kinase GJU35_23235 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_23240 ENOG4105EYF MMPL domain protein GJU35_23265 ENOG4108HMN Caspase domain GJU35_23285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GJU35_23375 ENOG4105FDP GntR family transcriptional regulator GJU35_23385 ENOG4105CZE histidine utilization repressor GJU35_23435 ENOG4106CY5 excisionase GJU35_23440 ENOG4107T65 Integrase GJU35_23460 ENOG4105C12 Phosphoribosylglycinamide synthetase GJU35_23475 ENOG4105C8V SAICAR synthetase GJU35_23520 ENOG410839H phosphoribosylformylglycinamidine synthase GJU35_23525 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GJU35_23530 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii GJU35_23565 ENOG4105CXB phosphoribosylaminoimidazole synthetase GJU35_23575 ENOG4107RDP Dehydrogenase GJU35_23580 ENOG4108TAC GJU35_23600 ENOG4105CQ7 ATP-dependent helicase GJU35_23635 ENOG4105C1J atp-dependent rna helicase GJU35_23660 ENOG4105VBF alkaline shock protein GJU35_23670 ENOG4105VEQ Cold shock protein GJU35_23675 ENOG4105C1J atp-dependent rna helicase GJU35_23695 ENOG4105VEQ Cold shock protein GJU35_23745 ENOG4105ESF Peptidoglycan binding domain protein GJU35_23755 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_23760 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) GJU35_23800 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GJU35_23805 ENOG4105D5U fad dependent oxidoreductase GJU35_23870 ENOG4108VB1 regulatoR GJU35_23875 ENOG4105BZU Histidine kinase GJU35_23925 ENOG4105PDP Short chain dehydrogenase GJU35_23945 ENOG4108762 serine threonine protein kinase GJU35_23950 ENOG4105E4C Lytic transglycosylase catalytic GJU35_23955 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GJU35_23960 ENOG4105DNP FAD linked oxidase domain protein GJU35_23975 ENOG4105VPX protein, conserved in bacteria GJU35_23985 ENOG4105CJ3 phosphate transporter GJU35_23995 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GJU35_24025 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GJU35_24040 ENOG4105D5T phosphonate abc transporter GJU35_24045 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GJU35_24060 ENOG4105CIG ABC transporter GJU35_24075 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GJU35_24080 ENOG4105CGH 5'-nucleotidase GJU35_24090 ENOG4105BZ1 (ABC) transporter GJU35_24105 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GJU35_24115 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GJU35_24145 ENOG4105ETX regulatoR GJU35_24160 ENOG4105ETE Transcriptional regulator (LacI family GJU35_24165 ENOG4107NHD transcriptional regulator GJU35_24190 ENOG4105PKJ carbohydrate binding GJU35_24195 ENOG4105KHC sulfurtransferase GJU35_24230 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands GJU35_24235 ENOG41090R7 Ferric uptake GJU35_24240 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GJU35_24245 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GJU35_24255 ENOG4105HHS UPF0256 protein GJU35_24280 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GJU35_24305 ENOG4105EEM helicase GJU35_24315 ENOG4105JSC dimethylmenaquinone methyltransferase GJU35_24330 ENOG4108IXY short-chain dehydrogenase reductase GJU35_24335 ENOG4105EMU Dehydrogenase GJU35_24350 ENOG4105DXX methyltransferase GJU35_24365 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GJU35_24395 ENOG4105K4H Nlp p60 protein GJU35_24410 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GJU35_24415 ENOG4108YZJ Pfam:DUF2596 GJU35_24440 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GJU35_24535 ENOG4108VJ1 Transcriptional regulator (CarD family GJU35_24540 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GJU35_24545 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GJU35_24550 ENOG4105C8N cysteinyl-tRNA synthetase GJU35_24580 ENOG4105D7V transposase GJU35_24685 ENOG4105BZU Histidine kinase GJU35_24695 ENOG4105DE4 1-phosphofructokinase GJU35_24700 ENOG4105CI2 imidazolone-5-propionate hydrolase GJU35_24710 ENOG4108IJG ABC transporter substrate-binding protein GJU35_24730 ENOG4105C3Q Glycosyl transferase, family 2 GJU35_24750 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GJU35_24760 ENOG4105EBR Carboxylesterase GJU35_24780 ENOG4108HMN Caspase domain GJU35_24810 ENOG4107S5I aldo keto reductase GJU35_24830 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GJU35_24835 ENOG4105QEK Transcriptional regulator GJU35_24855 ENOG4105KNA -acetyltransferase GJU35_24860 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GJU35_24880 ENOG4106N3A copper homeostasis protein cutc GJU35_24885 ENOG4105EEM helicase GJU35_24895 ENOG4105CFI type iii restriction protein res subunit GJU35_24910 ENOG4105CVA phosphate GJU35_24930 ENOG4105VEQ Cold shock protein GJU35_24935 ENOG4105E63 Pfam:DUF178 GJU35_24940 ENOG4108UIH futalosine nucleosidase GJU35_24950 ENOG4108N0W Major Facilitator superfamily GJU35_24990 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GJU35_25000 ENOG4105C7N Xanthine uracil vitamin C permease GJU35_25030 ENOG4105CPC Aldo Keto reductase GJU35_25045 ENOG4106JUT Streptomycin 3''-adenylyltransferase GJU35_25075 ENOG4106R7G Glycoside hydrolase family 5 GJU35_25080 ENOG4106JDR secreted GJU35_25085 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GJU35_25090 ENOG4105CQB FAD linked oxidase domain protein GJU35_25125 ENOG4105DXX methyltransferase GJU35_25130 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap GJU35_25180 ENOG4107QX3 carboxylase GJU35_25195 ENOG4105CEY Amp-dependent synthetase and ligase GJU35_25210 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GJU35_25235 ENOG4108SU4 UPF0309 protein GJU35_25245 ENOG4108XEP Alpha Beta Hydrolase Fold protein GJU35_25295 ENOG4105K6V RNA polymerase GJU35_25300 ENOG41082AN stage II sporulation protein GJU35_25305 ENOG4107EG8 signal transduction protein with EFhand domain GJU35_25320 ENOG4105CC9 acyl-Coa dehydrogenase GJU35_25325 ENOG4105D2B acyl-CoA dehydrogenase GJU35_25340 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr GJU35_25345 ENOG4105CC9 acyl-Coa dehydrogenase GJU35_25365 ENOG4105D2S major facilitator superfamily GJU35_25375 ENOG4105CGU Enoyl-CoA hydratase GJU35_25385 ENOG4105H3G oxidoreductase GJU35_25415 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GJU35_25430 ENOG4105D2B acyl-CoA dehydrogenase GJU35_25440 ENOG4105N14 lysine exporter protein LysE YggA GJU35_25445 ENOG4108ZRZ Transcriptional regulator (AsnC family) GJU35_25450 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GJU35_25460 ENOG4108762 serine threonine protein kinase GJU35_25490 ENOG4105CEY Amp-dependent synthetase and ligase GJU35_25515 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_25550 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GJU35_25575 ENOG41082YX Transcriptional regulator, arsr family GJU35_25645 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GJU35_25670 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GJU35_25695 ENOG4105DZ1 carboxypeptidase GJU35_25720 ENOG4108V06 Glutathione peroxidase GJU35_25765 ENOG4105BZU Histidine kinase GJU35_25770 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_25790 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator GJU35_25795 ENOG4105C2J ABC transporter GJU35_25800 ENOG4107R9N ABC transporter GJU35_25805 ENOG41062B0 ABC transporter, permease GJU35_25850 ENOG4105C3M thioredoxin reductase GJU35_25855 ENOG4105CUX Signal transduction histidine kinase GJU35_25910 ENOG4105E1F short-chain dehydrogenase reductase GJU35_25925 ENOG4108J2P Alpha beta hydrolase fold GJU35_25945 ENOG41060BG Tetr family transcriptional regulator GJU35_25955 ENOG4105C57 major facilitator superfamily GJU35_25980 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GJU35_25990 ENOG4107HP6 Transcriptional regulator GJU35_26015 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GJU35_26020 ENOG4105I8R Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GJU35_26035 ENOG410804X Transcriptional regulator GJU35_26045 ENOG4105DM4 PTS System GJU35_26060 ENOG4105FF0 ErfK YbiS YcfS YnhG GJU35_26065 ENOG4105KXX peptidase s58 dmpa GJU35_26075 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GJU35_26085 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) GJU35_26110 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase GJU35_26115 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GJU35_26125 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GJU35_26130 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GJU35_26155 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GJU35_26160 ENOG4105ENE Histidine kinase GJU35_26165 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_26170 ENOG4105VEV -acetyltransferase GJU35_26175 ENOG4105CGK Exodeoxyribonuclease III GJU35_26190 ENOG4105F95 Monooxygenase GJU35_26195 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GJU35_26200 ENOG4108R85 Short chain dehydrogenase GJU35_26220 ENOG4105EYF MMPL domain protein GJU35_26235 ENOG4108ZBR Gcn5-related n-acetyltransferase GJU35_26250 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GJU35_26270 ENOG4108JJB ABC transporter GJU35_26280 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GJU35_26285 ENOG4105KF0 sporulation and cell division protein, SsgA GJU35_26320 ENOG4105F8V Hydrolase, tatD family GJU35_26325 ENOG41069ER domain protein GJU35_26330 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GJU35_26335 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GJU35_26340 ENOG4105C5H ABC transporter GJU35_26380 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GJU35_26415 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_26420 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GJU35_26425 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GJU35_26440 ENOG41067SE Tetr family transcriptional regulator GJU35_26450 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) GJU35_26465 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GJU35_26470 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GJU35_26475 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GJU35_26480 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GJU35_26495 ENOG4105BZU Histidine kinase GJU35_26525 ENOG4107QN1 sodium solute GJU35_26550 ENOG4105C0R drug resistance transporter emrb qaca subfamily GJU35_26555 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GJU35_26560 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GJU35_26605 ENOG4106A3M Cytochrome p-450 GJU35_26610 ENOG4105MS9 Resuscitation-promoting factor GJU35_26620 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GJU35_26640 ENOG4105CEP NADH dehydrogenase GJU35_26645 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GJU35_26650 ENOG4107RBB ABC transporter, permease GJU35_26655 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GJU35_26690 ENOG4105CHU acetyl-coa acetyltransferase GJU35_26715 ENOG4105E90 ABC transporter GJU35_26720 ENOG4105R40 Glycine betaine carnitine choline GJU35_26725 ENOG4108IJ8 ABC transporter GJU35_26770 ENOG4105CGP Urocanate hydratase GJU35_26785 ENOG4105CI2 imidazolone-5-propionate hydrolase GJU35_26815 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GJU35_26820 ENOG41082AN stage II sporulation protein GJU35_26845 ENOG4105DUX Transporter GJU35_26850 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GJU35_26855 ENOG41065SU Two-component system sensor kinase GJU35_26870 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GJU35_26880 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GJU35_26920 ENOG4108PG2 copper resistance GJU35_26930 ENOG4105C6Y Udp-glucose 6-dehydrogenase GJU35_26955 ENOG4108KGH TRANSCRIPTIONal GJU35_26965 ENOG4108KGH TRANSCRIPTIONal GJU35_26970 ENOG4105K64 Glycosyl transferase, family 2 GJU35_26975 ENOG4108KGH TRANSCRIPTIONal GJU35_26980 ENOG4107TB5 TRANSCRIPTIONal GJU35_27005 ENOG4107V9E glucose-1-phosphate thymidylyltransferase GJU35_27015 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) GJU35_27030 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GJU35_27035 ENOG4107RGC Glycosyl transferase, family 2 GJU35_27055 ENOG4105DAA L-lactate GJU35_27060 ENOG4107QKV phosphomannomutase GJU35_27065 ENOG4105W49 UPF0434 protein GJU35_27075 ENOG4105EIP mannose-6-phosphate isomerase GJU35_27090 ENOG4105DM4 PTS System GJU35_27095 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) GJU35_27135 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GJU35_27140 ENOG4108WQ6 secreted protein GJU35_27155 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GJU35_27160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GJU35_27165 ENOG4105BZU Histidine kinase GJU35_27170 ENOG4105G3P Lipoprotein lpqB GJU35_27180 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea GJU35_27185 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_27190 ENOG4105T0Z Conserved Protein GJU35_27200 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GJU35_27225 ENOG4105C7I Dehydrogenase GJU35_27230 ENOG4105EY8 ABC transporter GJU35_27260 ENOG4105K56 Transcriptional regulator GJU35_27265 ENOG4108ZHJ Organic hydroperoxide resistance protein GJU35_27280 ENOG4105K64 Glycosyl transferase, family 2 GJU35_27285 ENOG4107SJB teichoic acid biosynthesis GJU35_27290 ENOG4107SJB teichoic acid biosynthesis GJU35_27295 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GJU35_27315 ENOG4108UGD Serine Threonine protein kinase GJU35_27320 ENOG4108QVN serine threonine protein kinase GJU35_27325 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GJU35_27340 ENOG4105CAK Cell division ATP-binding protein ftsE GJU35_27350 ENOG4105CN1 protease GJU35_27355 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GJU35_27380 ENOG4105CJQ hydrolase, family 31 GJU35_27405 ENOG4105CN8 Transcriptional regulator GJU35_27425 ENOG4105DQQ Major facilitator superfamily MFS_1 GJU35_27455 ENOG4105EEM helicase GJU35_27465 ENOG4108426 dNA-binding protein GJU35_27470 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GJU35_27475 ENOG4108UJU UPF0301 protein GJU35_27500 ENOG4105E2D ec 3.2.1.52 GJU35_27515 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GJU35_27535 ENOG4105C0R drug resistance transporter emrb qaca subfamily GJU35_27545 ENOG41086VY Fic/DOC family GJU35_27580 ENOG4108IJ8 ABC transporter GJU35_27585 ENOG4105E90 ABC transporter GJU35_27595 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GJU35_27620 ENOG4105CQB FAD linked oxidase domain protein GJU35_27625 ENOG4105KF0 sporulation and cell division protein, SsgA GJU35_27655 ENOG4108RWI nicotinamidase GJU35_27665 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GJU35_27675 ENOG4105C85 amino acid GJU35_27685 ENOG4105ETE Transcriptional regulator (LacI family GJU35_27710 ENOG4108RQ5 Beta-lactamase domain-containing protein GJU35_27730 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GJU35_27740 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GJU35_27775 ENOG4105KPY Small multidrug resistance protein GJU35_27780 ENOG4105BZ4 penicillin-binding protein GJU35_27810 ENOG4106BRA Membrane GJU35_27815 ENOG4107QNK )-transporter GJU35_27840 ENOG41087EV Hsp20/alpha crystallin family GJU35_27950 ENOG4107R4E Membrane GJU35_27965 ENOG41090KN UPF0303 protein GJU35_27970 ENOG4105D9R oxidoreductase GJU35_27975 ENOG4105DKQ ROK family GJU35_28005 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) GJU35_28050 ENOG4107H3J ribonuclease GJU35_28065 ENOG4107RN3 metallophosphoesterase GJU35_28085 ENOG4105BZU Histidine kinase GJU35_28090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GJU35_28095 ENOG4105EYF MMPL domain protein GJU35_28150 ENOG4108J01 L-aspartate oxidase GJU35_28170 ENOG4105E2D ec 3.2.1.52 GJU35_28205 ENOG4108MMM RNA Polymerase GJU35_28220 ENOG4105D5P Methylmalonyl-coA mutase GJU35_28270 ENOG4105CKK Glycosyl transferase, family 2 GJU35_28285 ENOG4105K64 Glycosyl transferase, family 2 GJU35_28295 ENOG4105F0R Cytidylyltransferase GJU35_28300 ENOG4105D2T synthase GJU35_28310 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GJU35_28320 ENOG4107RM1 amidohydrolase GJU35_28325 ENOG4105DIH basic membrane GJU35_28330 ENOG4108JQ9 ABC transporter GJU35_28335 ENOG4105UIB (ABC) transporter GJU35_28375 ENOG4105D94 Major Facilitator Superfamily GJU35_28380 ENOG4107RSM transcriptional regulator GJU35_28390 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GJU35_28415 ENOG41065SU Two-component system sensor kinase GJU35_28420 ENOG4108KXV response regulator GJU35_28425 ENOG4105NAF rna polymerase sigma factor GJU35_28430 ENOG4105DBI uridine monophosphokinase GJU35_28445 ENOG4105C26 Dehydrogenase GJU35_28465 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain GJU35_28495 ENOG4108JIK carboxylase GJU35_28505 ENOG4107WR6 Maf-like protein GJU35_28520 ENOG4105D8K carboxyl transferase GJU35_28530 ENOG4108QER Adenylate cyclase GJU35_28540 ENOG4105E39 Enoyl-CoA hydratase GJU35_28545 ENOG4105KDM Diguanylate cyclase with gaf sensor GJU35_28550 ENOG4105C84 Histidine ammonia-lyase GJU35_28580 ENOG4105C19 ABC transporter GJU35_28600 ENOG4105DQ4 alcohol dehydrogenase GJU35_28605 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GJU35_28610 ENOG4105TVJ transport system, permease GJU35_28615 ENOG4105DQ5 transport system permease protein GJU35_28655 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GJU35_28670 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GJU35_28695 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GJU35_28700 ENOG4105C7B Threonine dehydratase GJU35_28715 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GJU35_28725 ENOG4105T1M mycothiol conjugate amidase mca GJU35_28735 ENOG4107R3N Filamentation induced by cAMP protein fic GJU35_28740 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GJU35_28745 ENOG4105C7Z Conserved Protein GJU35_28760 ENOG4105CND Glycosyl transferase, family 2 GJU35_28775 ENOG4105C57 major facilitator superfamily GJU35_28785 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) GJU35_28845 ENOG4108FUF Transcriptional regulator, IclR family GJU35_28850 ENOG4105KME endoribonuclease L-psp GJU35_28855 ENOG4105C6Z Gluconate GJU35_28955 ENOG4108N5B 2-phosphosulfolactate phosphatase GJU35_29025 ENOG4105BZU Histidine kinase GJU35_29075 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GJU35_29080 ENOG4108IAB Phoh family GJU35_29085 ENOG4106770 Is able to cleave peptidoglycan (By similarity) GJU35_29105 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GJU35_29125 ENOG4105BZ4 penicillin-binding protein GJU35_29170 ENOG4105C9Q fumarate hydratase class II GJU35_29175 ENOG4107GFK fumarate GJU35_29185 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GJU35_29200 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) GJU35_29210 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GJU35_29225 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GJU35_29240 ENOG4105C3G gtp-binding protein GJU35_29255 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GJU35_29260 ENOG4107T4Z adenosine kinase GJU35_29265 ENOG4105C3R Methionine synthase GJU35_29310 ENOG4106IBR Cupin domain GJU35_29325 ENOG4107SM8 Adenylate Guanylate cyclase GJU35_29335 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) GJU35_29350 ENOG41061GT Aldolase GJU35_29355 ENOG4106M32 3-dehydroquinate synthase GJU35_29365 ENOG4105DZS Phenylacetate-CoA ligase GJU35_29375 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GJU35_29390 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GJU35_29410 ENOG4105DYW oxidoreductase GJU35_29420 ENOG4108S01 response regulator GJU35_29430 ENOG4105CHR reductase GJU35_29440 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin GJU35_29495 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GJU35_29520 ENOG4105CI3 gtp-binding protein typa GJU35_29525 ENOG4107QSI ABC, transporter GJU35_29535 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GJU35_29540 ENOG4105C3U ABC transporter GJU35_29545 ENOG4108JQ7 (ABC) transporter GJU35_29555 ENOG4108JQ7 (ABC) transporter GJU35_29565 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GJU35_29570 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GJU35_29575 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GJU35_29615 ENOG4108M15 ABC transporter GJU35_29625 ENOG4105BZU Histidine kinase GJU35_29630 ENOG4108S01 response regulator GJU35_29645 ENOG4108Z4U Ferredoxin GJU35_29665 ENOG4107R4C succinyl-diaminopimelate desuccinylase GJU35_29670 ENOG4108URH decarboxylase GJU35_29675 ENOG4105EEI dihydropteroate synthase GJU35_29685 ENOG4108R3E Dna-3-methyladenine glycosylase i GJU35_29690 ENOG4105CGU Enoyl-CoA hydratase GJU35_29705 ENOG4105DU6 RNA polymerase GJU35_29720 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GJU35_29755 ENOG4105D7N magnesium and cobalt transport protein CorA GJU35_29765 ENOG4105DXB Major Facilitator superfamily GJU35_29780 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GJU35_29840 ENOG4105DEF Extracellular solute-binding protein, family 5 GJU35_29845 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GJU35_29860 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GJU35_29910 ENOG4105C4R Atp-dependent dna helicase GJU35_29915 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GJU35_29940 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GJU35_30005 ENOG41063PX domain protein GJU35_30015 ENOG4105DJZ UPF0182 protein GJU35_30060 ENOG4107TK4 histidinol-phosphate phosphatase GJU35_30075 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GJU35_30080 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GJU35_30090 ENOG4108RAV Conserved protein GJU35_30100 ENOG4105EMN RNA polymerase sigma factor GJU35_30105 ENOG4105WMN AntiSigma factor GJU35_30130 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GJU35_30145 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GJU35_30155 ENOG41068W2 Cytochrome p-450 GJU35_30160 ENOG4105ECQ AraC Family Transcriptional Regulator GJU35_30175 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GJU35_30180 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GJU35_30205 ENOG4105D22 carbon starvation protein GJU35_30210 ENOG4105FDP GntR family transcriptional regulator GJU35_30230 ENOG4105D17 glycoside hydrolase, family 3 domain protein GJU35_30235 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GJU35_30240 ENOG4105CHR reductase GJU35_30260 ENOG4105CBD Diacylglycerol kinase GJU35_30290 ENOG4105K6H D-cysteine desulfhydrase GJU35_30300 ENOG4105ESN nucleotide-binding protein GJU35_30335 ENOG4105CHP RNA polymerase GJU35_30355 ENOG4105ECQ AraC Family Transcriptional Regulator GJU35_30370 ENOG4105CSR polyphosphate kinase 2 GJU35_30380 ENOG4108VEQ Superoxide dismutase GJU35_30415 ENOG4105C19 ABC transporter GJU35_30420 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GJU35_30425 ENOG4105CDA abc transporter atp-binding protein GJU35_30440 ENOG4105C6K Malic enzyme GJU35_30445 ENOG4105CB2 alcohol dehydrogenase GJU35_30525 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GJU35_30530 ENOG4105EB3 Histidine kinase GJU35_30535 ENOG4108PYU two-component system response regulator GJU35_30550 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GJU35_30630 ENOG41060BG Tetr family transcriptional regulator GJU35_30660 ENOG4108FKE two-component system sensor kinase GJU35_30685 ENOG4105DQE DNA ligase GJU35_30690 ENOG4105FDF Could be involved in DNA repair (By similarity) GJU35_30765 ENOG4105E09 nadh pyrophosphatase GJU35_30880 ENOG4105ETX regulatoR GJU35_30885 ENOG4105C75 arginyL-tRNA synthetase GJU35_30890 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GJU35_30895 ENOG4105D6E homoserine dehydrogenase GJU35_30900 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GJU35_30905 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GJU35_30915 ENOG4108RCF TRANSCRIPTIONal GJU35_30920 ENOG4105VFB Binds the 23S rRNA (By similarity) GJU35_30925 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GJU35_30930 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GJU35_30940 ENOG4107ZF2 Phosphatase GJU35_30945 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GJU35_30955 ENOG4105Z3P ATP synthase GJU35_30965 ENOG4105ZA1 atp synthase GJU35_30970 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) GJU35_30975 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GJU35_30980 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GJU35_30985 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GJU35_30990 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GJU35_30995 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GJU35_31010 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_31015 ENOG4105BZU Histidine kinase GJU35_31020 ENOG4105IIP Membrane GJU35_31035 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GJU35_31050 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) GJU35_31085 ENOG4105CJ1 ABC, transporter GJU35_31105 ENOG4108ZVT methylmalonyl-coA epimerase GJU35_31110 ENOG4105CHU acetyl-coa acetyltransferase GJU35_31125 ENOG4105ETX regulatoR GJU35_31195 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) GJU35_31205 ENOG4105WX6 Membrane GJU35_31250 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GJU35_31255 ENOG4105C6K Malic enzyme GJU35_31260 ENOG4105CTQ phosphohexokinase GJU35_31300 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GJU35_31305 ENOG4105WEM extracellular solute-binding protein GJU35_31310 ENOG4108MRH transcriptional regulatory protein GJU35_31315 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GJU35_31320 ENOG4107QJT sodium dicarboxylate symporter GJU35_31410 ENOG4105C57 major facilitator superfamily GJU35_31445 ENOG4108FN7 Aldo keto reductase GJU35_31465 ENOG4105C3M thioredoxin reductase GJU35_31480 ENOG4106A3M Cytochrome p-450 GJU35_31495 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GJU35_31500 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) GJU35_31510 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) GJU35_31520 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GJU35_31540 ENOG4105BZ1 (ABC) transporter GJU35_31545 ENOG4105BZ1 (ABC) transporter GJU35_31550 ENOG4105BZ1 (ABC) transporter GJU35_31555 ENOG4105BZ1 (ABC) transporter GJU35_31570 ENOG4105BZU Histidine kinase GJU35_31575 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_31655 ENOG4107YXZ hydrolase, family 25 GJU35_31660 ENOG4105C0W non-ribosomal peptide synthetase GJU35_31680 ENOG4105C0W non-ribosomal peptide synthetase GJU35_31710 ENOG4105EJQ L-serine dehydratase GJU35_31715 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GJU35_31720 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GJU35_31725 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GJU35_31745 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GJU35_31760 ENOG4105C3U ABC transporter GJU35_31765 ENOG4108JQ7 (ABC) transporter GJU35_31770 ENOG4105EN6 Membrane GJU35_31785 ENOG4105D29 Helix-turn-helix type 11 domain protein GJU35_31815 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GJU35_31820 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GJU35_31830 ENOG4108URH decarboxylase GJU35_31835 ENOG4105EMU Dehydrogenase GJU35_31845 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GJU35_31850 ENOG4105BZU Histidine kinase GJU35_31855 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GJU35_31860 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GJU35_31870 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GJU35_31875 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GJU35_31885 ENOG4105EYF MMPL domain protein GJU35_31890 ENOG4105D9U N-acetyltransferase GJU35_31905 ENOG4107SM8 Adenylate Guanylate cyclase GJU35_31920 ENOG4105CPC Aldo Keto reductase GJU35_31945 ENOG4108ZP8 Acetolactate synthase small subunit GJU35_31950 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GJU35_31955 ENOG4108JQ1 Dehydrogenase GJU35_31960 ENOG4105C57 major facilitator superfamily GJU35_31970 ENOG4108JQ7 (ABC) transporter GJU35_31980 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GJU35_32010 ENOG41062BK proline dehydrogenase GJU35_32015 ENOG4105C26 Dehydrogenase GJU35_32035 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GJU35_32040 ENOG4105CM2 brancheD-chain amino acid aminotransferase GJU35_32045 ENOG4105FQP Beta-lactamase GJU35_32065 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GJU35_32075 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GJU35_32085 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap GJU35_32100 ENOG4108HMN Caspase domain GJU35_32110 ENOG4108YYC ycei family GJU35_32115 ENOG4106AM8 polysaccharide lyase family 8 GJU35_32120 ENOG4105D8K carboxyl transferase GJU35_32140 ENOG4105GWZ Roadblock lc7 family protein GJU35_32160 ENOG4105GWZ Roadblock lc7 family protein GJU35_32175 ENOG4105ERH Fumarylacetoacetate hydrolase GJU35_32180 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GJU35_32220 ENOG41069M3 Transcriptional regulator GJU35_32225 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GJU35_32230 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GJU35_32240 ENOG4105K70 DNA-binding protein GJU35_32260 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GJU35_32265 ENOG4105CPF Cell wall formation (By similarity) GJU35_32285 ENOG4105DWF phosphomethylpyrimidine kinase GJU35_32290 ENOG4105VB9 50S ribosomal protein l28 GJU35_32295 ENOG4105DP4 dak2 domain fusion protein ylov GJU35_32320 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GJU35_32335 ENOG41084BZ 50S ribosomal protein L32 GJU35_32340 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GJU35_32345 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GJU35_32350 ENOG4105KVH Transcriptional regulator GJU35_32355 ENOG4105K4I Scp-like extracellular GJU35_32360 ENOG4108375 Acylphosphatase (EC 3.6.1.7) GJU35_32370 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GJU35_32410 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GJU35_32420 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GJU35_32430 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) GJU35_32440 ENOG4105K5M 30s ribosomal protein S16 GJU35_32445 ENOG41082KU UPF0109 protein GJU35_32450 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GJU35_32455 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GJU35_32460 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GJU35_32470 ENOG4107QYR Signal peptidase i GJU35_32475 ENOG4107QYR Signal peptidase i GJU35_32495 ENOG41080R2 UPF0102 protein GJU35_32510 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GJU35_32525 ENOG4105CE9 30S ribosomal protein S2 GJU35_32530 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GJU35_32535 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GJU35_32540 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GJU35_32545 ENOG4105KNE Phosphatidate cytidylyltransferase GJU35_32595 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GJU35_32605 ENOG4108I5D sulfate abc transporter GJU35_32610 ENOG4108UCS ABC, transporter GJU35_32640 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GJU35_32645 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GJU35_32655 ENOG4105C26 Dehydrogenase GJU35_32695 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GJU35_32700 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GJU35_32730 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GJU35_32735 ENOG4105F38 ABC transporter, permease GJU35_32740 ENOG4105D38 putrescine abc transporter GJU35_32745 ENOG4105CJP fad dependent oxidoreductase GJU35_32775 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GJU35_32780 ENOG4105E0S extracellular solute-binding protein family 1 GJU35_32790 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component GJU35_32835 ENOG4108762 serine threonine protein kinase GJU35_32845 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GJU35_32850 ENOG4105DZP Membrane-associated zinc metalloprotease GJU35_32855 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GJU35_32870 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GJU35_32875 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase GJU35_32890 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) GJU35_32905 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GJU35_32915 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GJU35_32920 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GJU35_33015 ENOG4105EC2 ftsk spoIIIe GJU35_33030 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GJU35_33035 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GJU35_33040 ENOG4105C1V Peptidase, M16 GJU35_33045 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GJU35_33070 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GJU35_33110 ENOG4105BZU Histidine kinase GJU35_33115 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GJU35_33120 ENOG4107QZI cell division protein FtsK GJU35_33130 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) GJU35_33140 ENOG4105CEV competence damage-inducible protein GJU35_33145 ENOG4105WBV Transcriptional regulator GJU35_33150 ENOG4105CHR reductase GJU35_33155 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) GJU35_33160 ENOG4107QRT dEAD DEAH box helicase GJU35_33185 ENOG4105DSF transport protein GJU35_33220 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase GJU35_33225 ENOG4105DRP amino acid AbC transporter GJU35_33230 ENOG4108Q1T ABC transporter GJU35_33235 ENOG4107UBR Extracellular solute-binding protein family 3 GJU35_33240 ENOG4105CDA abc transporter atp-binding protein GJU35_33245 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GJU35_33250 ENOG4105EB3 Histidine kinase GJU35_33255 ENOG4105H1G trap transporter solute receptor taxi family GJU35_33270 ENOG4105BZU Histidine kinase GJU35_33275 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_33290 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) GJU35_33300 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GJU35_33320 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GJU35_33330 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GJU35_33335 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GJU35_33345 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GJU35_33385 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GJU35_33390 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GJU35_33395 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GJU35_33430 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GJU35_33445 ENOG4105C9U ATP-dependent DNA helicase RecQ GJU35_33460 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GJU35_33470 ENOG4105DRR Transcriptional regulator, GntR family GJU35_33475 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GJU35_33490 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GJU35_33505 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_33515 ENOG4107QN1 sodium solute GJU35_33520 ENOG4108V9W transcriptional regulatory protein GJU35_33535 ENOG4105BZN citrate synthase GJU35_33540 ENOG4105BZN citrate synthase GJU35_33560 ENOG4107QRP cobalamin biosynthesis protein CobW GJU35_33565 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GJU35_33585 ENOG4105DRR Transcriptional regulator, GntR family GJU35_33590 ENOG410849S phosphocarrier protein (HPr) GJU35_33595 ENOG4105CD5 CoA-binding domain protein GJU35_33610 ENOG4107W53 thymidine kinase GJU35_33640 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GJU35_33650 ENOG4105F44 Two component transcriptional regulator, winged helix family GJU35_33655 ENOG4106F60 Histidine kinase GJU35_33680 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GJU35_33695 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GJU35_33725 ENOG4107VEG TrkA-N domain protein GJU35_33730 ENOG4105C0X amino acid GJU35_33735 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GJU35_33755 ENOG4107QRT dEAD DEAH box helicase GJU35_33800 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GJU35_33830 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GJU35_33835 ENOG4108RVA ribokinase GJU35_33840 ENOG4105C2J ABC transporter GJU35_33845 ENOG4105CNN ABC, transporter GJU35_33850 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GJU35_33905 ENOG41082BM Transcriptional regulator, arsr family GJU35_33955 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GJU35_33995 ENOG4105K64 Glycosyl transferase, family 2 GJU35_34005 ENOG4105CJ1 ABC, transporter GJU35_34055 ENOG4105CAQ asparagine synthetase GJU35_34060 ENOG4108IAJ Nad-dependent epimerase dehydratase GJU35_34065 ENOG4105BZ1 (ABC) transporter GJU35_34075 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GJU35_34080 ENOG4105CEY Amp-dependent synthetase and ligase GJU35_34090 ENOG4107S1Q Phosphatase GJU35_34100 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GJU35_34135 ENOG4105CEU Arginine dihydrolase GJU35_34140 ENOG4105DBV ornithine carbamoyltransferase GJU35_34150 ENOG4105CGU Enoyl-CoA hydratase GJU35_34155 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GJU35_34200 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GJU35_34210 ENOG4108D32 Methyltransferase GJU35_34220 ENOG4107QM5 aconitate hydratase GJU35_34230 ENOG4105BZU Histidine kinase GJU35_34240 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) GJU35_34245 ENOG4105NX3 Membrane GJU35_34255 ENOG4105I82 acetyl xylan esterase GJU35_34265 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component GJU35_34270 ENOG4105E0S extracellular solute-binding protein family 1 GJU35_34305 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GJU35_34315 ENOG4105E2R ROK family GJU35_34320 ENOG4105DFW ABC transporter GJU35_34325 ENOG4105C2J ABC transporter GJU35_34330 ENOG4108HWW ABC transporter GJU35_34335 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GJU35_34340 ENOG4105CUB amino acid GJU35_34350 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GJU35_34360 ENOG4107QQG Dehydrogenase GJU35_34375 ENOG4106R7G Glycoside hydrolase family 5 GJU35_34380 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GJU35_34385 ENOG4105CHU acetyl-coa acetyltransferase GJU35_34390 ENOG4105ETE Transcriptional regulator (LacI family GJU35_34405 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GJU35_34415 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GJU35_34430 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GJU35_34435 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_34440 ENOG4105E39 Enoyl-CoA hydratase GJU35_34450 ENOG4105DXX methyltransferase GJU35_34475 ENOG4105CHR reductase GJU35_34485 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GJU35_34490 ENOG4105CHR reductase GJU35_34495 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GJU35_34500 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GJU35_34520 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GJU35_34525 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GJU35_34530 ENOG4105C57 major facilitator superfamily GJU35_34540 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_34545 ENOG4105BZU Histidine kinase GJU35_34570 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GJU35_34585 ENOG4107JTW chlorite dismutase GJU35_34605 ENOG4105E18 UPF0276 protein GJU35_34615 ENOG4108IUX (ABC) transporter GJU35_34630 ENOG4108ZJ4 polysaccharide deacetylase GJU35_34655 ENOG4107B2H carbonic anhydrase GJU35_34680 ENOG4105DFU Cell wall formation (By similarity) GJU35_34685 ENOG4105E0X reductase GJU35_34690 ENOG4105E5M Multidrug resistance protein D GJU35_34695 ENOG4105YVS arsR family transcriptional regulator GJU35_34710 ENOG4105D17 glycoside hydrolase, family 3 domain protein GJU35_34725 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GJU35_34730 ENOG4105DRS transport system, permease GJU35_34755 ENOG4105QEK Transcriptional regulator GJU35_34760 ENOG4108SU4 UPF0309 protein GJU35_34765 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 GJU35_34785 ENOG4105DEF Extracellular solute-binding protein, family 5 GJU35_34835 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GJU35_34840 ENOG4105BZU Histidine kinase GJU35_34845 ENOG4105CMR udp-glucose 4-epimerase GJU35_34850 ENOG4105BZU Histidine kinase GJU35_34855 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GJU35_34880 ENOG4106A3M Cytochrome p-450 GJU35_34895 ENOG4108IJ8 ABC transporter GJU35_34900 ENOG4105E90 ABC transporter GJU35_34920 ENOG4105GWZ Roadblock lc7 family protein GJU35_34940 ENOG4105DKQ ROK family GJU35_34945 ENOG4108JQ6 ABC transporter GJU35_35005 ENOG41082SX arsR family transcriptional regulator GJU35_35010 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GJU35_35015 ENOG4108KGH TRANSCRIPTIONal GJU35_35020 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GJU35_35045 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GJU35_35055 ENOG41064MX Tetr family transcriptional regulator GJU35_35065 ENOG4108XG4 DNA-binding transcriptional regulator GJU35_35100 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein GJU35_35105 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GJU35_35115 ENOG4105C0H protease GJU35_35150 ENOG4105ZSU inhibitor GJU35_35245 ENOG4108KXV response regulator GJU35_35250 ENOG41065SU Two-component system sensor kinase GJU35_35305 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GJU35_35340 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GJU35_35365 ENOG4107RR1 TRANSCRIPTIONal GJU35_35370 ENOG4105CSU acyl-Coa dehydrogenase GJU35_35380 ENOG4105CIF Ornithine Cyclodeaminase GJU35_35485 ENOG4105ETE Transcriptional regulator (LacI family GJU35_35490 ENOG4105DSG hydrolase family 43 GJU35_35510 ENOG4105ETE Transcriptional regulator (LacI family GJU35_35515 ENOG4108JQ1 Dehydrogenase GJU35_35525 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GJU35_35530 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GJU35_35550 ENOG4105EBR Carboxylesterase GJU35_35555 ENOG4105ETE Transcriptional regulator (LacI family GJU35_35560 ENOG4108J5H Homocysteine s-methyltransferase GJU35_35565 ENOG4105D5Q Arginine ornithine antiporter GJU35_35600 ENOG4107TDE lipolytic protein G-D-S-L family GJU35_35665 ENOG4105CJ1 ABC, transporter GJU35_35695 ENOG4105QE3 oxidoreductase GJU35_35710 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) GJU35_35715 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GJU35_35725 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GJU35_35770 ENOG4105DRR Transcriptional regulator, GntR family GJU35_35795 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GJU35_35800 ENOG4105C7N Xanthine uracil vitamin C permease GJU35_35820 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GJU35_35825 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) GJU35_35830 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) GJU35_35840 ENOG4105EQ2 LysR family Transcriptional regulator GJU35_35860 ENOG4105KK4 UPF0060 membrane protein GJU35_35875 ENOG4105C09 Bile acid GJU35_35900 ENOG4108KEZ Dehydrogenase GJU35_35905 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GJU35_35940 ENOG4105D7N magnesium and cobalt transport protein CorA GJU35_35960 ENOG4108TM9 integral membrane protein GJU35_36030 ENOG4107RSM transcriptional regulator GJU35_36040 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap GJU35_36055 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GJU35_36060 ENOG4105CEY Amp-dependent synthetase and ligase GJU35_36065 ENOG4105ETE Transcriptional regulator (LacI family GJU35_36070 ENOG4106R7G Glycoside hydrolase family 5 GJU35_36080 ENOG41065HY 1,4-beta-cellobiosidase GJU35_36095 ENOG41060W2 glyoxylate carboligase GJU35_36100 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GJU35_36105 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GJU35_36125 ENOG4105VT2 5-hydroxyisourate hydrolase GJU35_36135 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GJU35_36160 ENOG4105KVH Transcriptional regulator GJU35_36175 ENOG4105CHM Aminotransferase GJU35_36195 ENOG4105DUU IucA IucC family protein GJU35_36220 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GJU35_36230 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GJU35_36255 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GJU35_36275 ENOG4105BZ1 (ABC) transporter GJU35_36305 ENOG4107R9S Malate synthase GJU35_36310 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GJU35_36325 ENOG4107HP6 Transcriptional regulator GJU35_36340 ENOG4105F6U Short-chain dehydrogenase reductase Sdr GJU35_36365 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_36375 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GJU35_36385 ENOG4105DKQ ROK family GJU35_36395 ENOG4105C0D helicase GJU35_36405 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GJU35_36410 ENOG4105E8R UPF0173 metal-dependent hydrolase GJU35_36430 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) GJU35_36440 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GJU35_36465 ENOG4107RSM transcriptional regulator GJU35_36470 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GJU35_36495 ENOG4105C8Y Acetylornithine aminotransferase GJU35_36510 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) GJU35_36520 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GJU35_36535 ENOG4105BZU Histidine kinase GJU35_36540 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_36545 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GJU35_36555 ENOG4105ECY inositol monophosphatase GJU35_36565 ENOG4108UVJ appr-1-p processing domain protein GJU35_36590 ENOG4107YBY Hydrolase GJU35_36615 ENOG4105ECQ AraC Family Transcriptional Regulator GJU35_36630 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_36645 ENOG4108EU3 peptide transport system, permease GJU35_36650 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GJU35_36655 ENOG4105DEF Extracellular solute-binding protein, family 5 GJU35_36660 ENOG4107QI1 Mate efflux family protein GJU35_36670 ENOG41066UM arsR family transcriptional regulator GJU35_36690 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GJU35_36705 ENOG4105BZW Glycerate kinase GJU35_36715 ENOG4108IV0 ABC, transporter GJU35_36720 ENOG4105C0Z ABC transporter GJU35_36725 ENOG4105C32 Amino acid ABC transporter (Permease) GJU35_36730 ENOG4105C32 Amino acid ABC transporter (Permease) GJU35_36750 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme GJU35_36755 ENOG4105C1G acyl-Coa dehydrogenase GJU35_36785 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GJU35_36805 ENOG4106JDR secreted GJU35_36825 ENOG4108Q50 Histidine kinase GJU35_36895 ENOG4106ARF phosphopantetheine-binding protein GJU35_36900 ENOG4105CZS beta-ketoacyl synthase GJU35_36935 ENOG4105C0R drug resistance transporter emrb qaca subfamily GJU35_36945 ENOG4108ME1 Peptidase M55 D-aminopeptidase GJU35_36950 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GJU35_36955 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein GJU35_36960 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GJU35_36990 ENOG4107JEE Short-chain dehydrogenase reductase Sdr GJU35_36995 ENOG4105DIA mandelate racemase muconate lactonizing GJU35_37000 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GJU35_37010 ENOG4105CV1 Transketolase (EC 2.2.1.1) GJU35_37015 ENOG4105DQE DNA ligase GJU35_37025 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth GJU35_37050 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) GJU35_37060 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) GJU35_37085 ENOG4105C5H ABC transporter GJU35_37100 ENOG4105CH6 catalase GJU35_37105 ENOG4107R7Y intracellular protease Pfpi family GJU35_37115 ENOG4105C2X Arabinose 5-phosphate isomerase GJU35_37165 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein GJU35_37205 ENOG4105CFG Acts as a chaperone (By similarity) GJU35_37235 ENOG410842T Pterin carbinolamine dehydratase GJU35_37240 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GJU35_37255 ENOG4105D29 Helix-turn-helix type 11 domain protein GJU35_37260 ENOG4105CX8 fg-gap repeat protein GJU35_37270 ENOG4105CYP glycoside hydrolase, family GJU35_37275 ENOG41065HY 1,4-beta-cellobiosidase GJU35_37285 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GJU35_37310 ENOG4105DUM transcriptional regulator, lysR family GJU35_37315 ENOG4105DHU Bile acid GJU35_37325 ENOG4108478 ec 3.2.1.18 GJU35_37330 ENOG4105D3W isochorismatase GJU35_37335 ENOG4105CHR reductase GJU35_37340 ENOG4106NZI LysR family Transcriptional regulator GJU35_37345 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GJU35_37355 ENOG4107QIZ NADH dehydrogenase GJU35_37360 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GJU35_37365 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GJU35_37380 ENOG4105EYF MMPL domain protein GJU35_37390 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GJU35_37405 ENOG4105DKQ ROK family GJU35_37410 ENOG4105C2J ABC transporter GJU35_37415 ENOG4105CNN ABC, transporter GJU35_37420 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GJU35_37450 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase GJU35_37490 ENOG4105FCD Major Facilitator GJU35_37510 ENOG4105CMV Succinyl-CoA synthetase subunit beta GJU35_37520 ENOG4105C26 Dehydrogenase GJU35_37540 ENOG4105DQ5 transport system permease protein GJU35_37545 ENOG4105TVJ transport system, permease GJU35_37550 ENOG4105E0A ABC, transporter GJU35_37555 ENOG4105J76 Periplasmic binding protein GJU35_37560 ENOG4105BZ1 (ABC) transporter GJU35_37570 ENOG4105BZ1 (ABC) transporter GJU35_37600 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GJU35_37635 ENOG4107RRN ABC transporter substrate-binding protein GJU35_37670 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GJU35_37690 ENOG4107QJN gtp cyclohydrolase ii GJU35_37695 ENOG4105F84 Ornithine cyclodeaminase GJU35_37725 ENOG410905P Pyridoxamine 5-phosphate GJU35_37730 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase GJU35_37740 ENOG4105CSH Transporter GJU35_37750 ENOG4107S9B Shikimate dehydrogenase GJU35_37765 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GJU35_37770 ENOG4108J5G 6-phosphogluconate dehydrogenase GJU35_37775 ENOG4107QP8 phosphohexose isomerase GJU35_37790 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GJU35_37815 ENOG4107R13 MMPL domain protein GJU35_37825 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_37830 ENOG4105BZU Histidine kinase GJU35_37845 ENOG4105CHR reductase GJU35_37870 ENOG41088CQ domain protein GJU35_37875 ENOG4105CNT hydrolase family 2 GJU35_37905 ENOG4105F8D glycoside hydrolase family 4 GJU35_37960 ENOG4105MWK D-amino acid dehydrogenase, small subunit GJU35_37975 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GJU35_37980 ENOG4105CTU Proline racemase GJU35_37995 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GJU35_38000 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GJU35_38010 ENOG4107HP6 Transcriptional regulator GJU35_38030 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_38080 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GJU35_38085 ENOG4105DRS transport system, permease GJU35_38110 ENOG4105CSH Transporter GJU35_38150 ENOG4107SM8 Adenylate Guanylate cyclase GJU35_38160 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GJU35_38165 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase GJU35_38170 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha GJU35_38180 ENOG4105CHU acetyl-coa acetyltransferase GJU35_38215 ENOG4105DQE DNA ligase GJU35_38240 ENOG4105ETE Transcriptional regulator (LacI family GJU35_38250 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GJU35_38260 ENOG4106V2I dimethylaminohydrolase GJU35_38265 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GJU35_38270 ENOG4105C5H ABC transporter GJU35_38295 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) GJU35_38300 ENOG4105EG6 Saccharopine dehydrogenase GJU35_38310 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GJU35_38315 ENOG4105C1G acyl-Coa dehydrogenase GJU35_38320 ENOG4105CHU acetyl-coa acetyltransferase GJU35_38325 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GJU35_38335 ENOG4108KEZ Dehydrogenase GJU35_38355 ENOG4108U3T pfkb domain protein GJU35_38375 ENOG4105C94 Transporter GJU35_38390 ENOG4105C5H ABC transporter GJU35_38400 ENOG4105BZM domain protein GJU35_38420 ENOG4105E39 Enoyl-CoA hydratase GJU35_38435 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GJU35_38460 ENOG4108MDK Dehydrogenase GJU35_38480 ENOG4105EY8 ABC transporter GJU35_38485 ENOG4105FBD synthase GJU35_38495 ENOG4107S11 squalene-associated FAD-dependent desaturase GJU35_38505 ENOG4105EWU Squalene--hopene cyclase GJU35_38520 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GJU35_38575 ENOG4105D82 Glutamate dehydrogenase GJU35_38620 ENOG4105CPQ Dehydrogenase GJU35_38625 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GJU35_38630 ENOG4106NZI LysR family Transcriptional regulator GJU35_38680 ENOG4105C5F glutamine synthetase GJU35_38695 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_38720 ENOG4105H1N peptidase, M24 GJU35_38725 ENOG4107RUY (E1 component), alpha subunit GJU35_38735 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GJU35_38740 ENOG4105YKW GJU35_38745 ENOG4105K6S Short-chain dehydrogenase reductase Sdr GJU35_38775 ENOG4105KME endoribonuclease L-psp GJU35_38825 ENOG4105BZ1 (ABC) transporter GJU35_38845 ENOG4107VIJ nudix hydrolase GJU35_38855 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) GJU35_38865 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GJU35_38880 ENOG4105CNN ABC, transporter GJU35_38885 ENOG4105C2J ABC transporter GJU35_38895 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GJU35_38900 ENOG4105EE0 oxidoreductase GJU35_38915 ENOG4105CHR reductase GJU35_38925 ENOG41060NJ transcriptional regulator GJU35_38935 ENOG4105ETE Transcriptional regulator (LacI family GJU35_38950 ENOG4105CPQ Dehydrogenase GJU35_38955 ENOG4108QBF Transcriptional regulator GJU35_38965 ENOG4105JSC dimethylmenaquinone methyltransferase GJU35_38985 ENOG4105C57 major facilitator superfamily GJU35_39015 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GJU35_39025 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GJU35_39040 ENOG4105D65 subunit l GJU35_39050 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GJU35_39080 ENOG4106S2D Transcriptional regulator GJU35_39105 ENOG4106A3M Cytochrome p-450 GJU35_39120 ENOG4105E9K Isocitrate dehydrogenase GJU35_39125 ENOG4105D64 Mechanosensitive ion channel GJU35_39140 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GJU35_39145 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein GJU35_39155 ENOG4105E39 Enoyl-CoA hydratase GJU35_39165 ENOG4105BZ1 (ABC) transporter GJU35_39205 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GJU35_39235 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GJU35_39255 ENOG4107QPH glycogen) synthase GJU35_39260 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GJU35_39280 ENOG4105CHR reductase GJU35_39330 ENOG41073TP transcriptional regulator GJU35_39340 ENOG4105C2J ABC transporter GJU35_39345 ENOG4105CNN ABC, transporter GJU35_39355 ENOG4105CHR reductase GJU35_39425 ENOG4108XEP Alpha Beta Hydrolase Fold protein GJU35_39430 ENOG4105CUB amino acid GJU35_39440 ENOG4105CRK lysyL-tRNA synthetase GJU35_39445 ENOG4108ZJ4 polysaccharide deacetylase GJU35_39480 ENOG4105BZU Histidine kinase GJU35_39485 ENOG4105C5Q Transcriptional regulator GJU35_39500 ENOG4105E33 succinate dehydrogenase GJU35_39515 ENOG4108Z20 Acyl-transferase GJU35_39525 ENOG4105DEN Luciferase family GJU35_39535 ENOG4105CKI cobalamin synthesis protein GJU35_39540 ENOG41068HZ 50S ribosomal protein L32 GJU35_39560 ENOG4105KVH Transcriptional regulator GJU35_39570 ENOG4105WKW Pfam:DUF1458 GJU35_39575 ENOG41067HS methyltransferase GJU35_39580 ENOG4108V75 Glutamine amidotransferase GJU35_39585 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process GJU35_39605 ENOG4105DZ6 Band 7 protein GJU35_39625 ENOG4108J2P Alpha beta hydrolase fold GJU35_39630 ENOG4105J4Q Transcriptional regulator GJU35_39635 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase GJU35_39690 ENOG4108KEZ Dehydrogenase GJU35_39735 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_39740 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr GJU35_39750 ENOG4105C26 Dehydrogenase GJU35_39790 ENOG4105ESF Peptidoglycan binding domain protein GJU35_39810 ENOG4107RN3 metallophosphoesterase GJU35_39825 ENOG4105BZU Histidine kinase GJU35_39830 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_39835 ENOG4105DRR Transcriptional regulator, GntR family GJU35_39870 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GJU35_39895 ENOG410880H cysteine synthase GJU35_39905 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GJU35_39910 ENOG4107XKF NMT1 THI5 Like Domain Protein GJU35_39945 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GJU35_39950 ENOG4105C1G acyl-Coa dehydrogenase GJU35_39960 ENOG4105C10 Electron transfer flavoprotein GJU35_39970 ENOG4107RSM transcriptional regulator GJU35_39975 ENOG4107QPD alcohol dehydrogenase GJU35_39990 ENOG4108N3Q Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GJU35_40000 ENOG4105ETE Transcriptional regulator (LacI family GJU35_40005 ENOG4105ERH Fumarylacetoacetate hydrolase GJU35_40010 ENOG4105D2S major facilitator superfamily GJU35_40015 ENOG4108JQ1 Dehydrogenase GJU35_40055 ENOG4108ZJ4 polysaccharide deacetylase GJU35_40060 ENOG4108HMN Caspase domain GJU35_40065 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GJU35_40075 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_40095 ENOG4105C57 major facilitator superfamily GJU35_40100 ENOG4108W6C Dehydrogenase GJU35_40140 ENOG4105XYF acetyltransferase GJU35_40150 ENOG4105CHR reductase GJU35_40155 ENOG4105VEQ Cold shock protein GJU35_40170 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GJU35_40180 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GJU35_40210 ENOG41081JD Transcriptional regulator GJU35_40215 ENOG4105ECB domain protein GJU35_40245 ENOG4105CHR reductase GJU35_40250 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GJU35_40260 ENOG4108KPJ rna polymerase sigma factor GJU35_40290 ENOG4105EYF MMPL domain protein GJU35_40305 ENOG4105BZU Histidine kinase GJU35_40310 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_40320 ENOG4108TGC Acyltransferase GJU35_40335 ENOG4105ETE Transcriptional regulator (LacI family GJU35_40345 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GJU35_40350 ENOG4105DRS transport system, permease GJU35_40365 ENOG4105EMU Dehydrogenase GJU35_40415 ENOG4107RSM transcriptional regulator GJU35_40425 ENOG4108YYH Nadph-dependent fmn reductase GJU35_40435 ENOG41060NJ transcriptional regulator GJU35_40445 ENOG41080RH Thioredoxin GJU35_40465 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GJU35_40485 ENOG4105EUB pirin domain protein GJU35_40495 ENOG4105CJ1 ABC, transporter GJU35_40520 ENOG4105EYF MMPL domain protein GJU35_40525 ENOG4105BZU Histidine kinase GJU35_40530 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_40560 ENOG4105ETE Transcriptional regulator (LacI family GJU35_40605 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein GJU35_40610 ENOG4105C32 Amino acid ABC transporter (Permease) GJU35_40620 ENOG4105C0Z ABC transporter GJU35_40625 ENOG4108IV0 ABC, transporter GJU35_40630 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GJU35_40645 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GJU35_40650 ENOG4105C3U ABC transporter GJU35_40655 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) GJU35_40660 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GJU35_40665 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit GJU35_40670 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit GJU35_40675 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit GJU35_40680 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GJU35_40685 ENOG4105ETE Transcriptional regulator (LacI family GJU35_40760 ENOG4105C19 ABC transporter GJU35_40770 ENOG41080R8 Conserved Protein GJU35_40775 ENOG4107QR9 Iron-sulfur cluster binding protein GJU35_40780 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GJU35_40785 ENOG4105DET Rhamnulokinase GJU35_40820 ENOG4105C2J ABC transporter GJU35_40825 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GJU35_40830 ENOG4105F5R ABC transporter GJU35_40835 ENOG4105D4B ABC, transporter GJU35_40850 ENOG4105ETE Transcriptional regulator (LacI family GJU35_40865 ENOG4108KPJ rna polymerase sigma factor GJU35_40880 ENOG4105DDN Pentapeptide repeat-containing protein GJU35_40885 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GJU35_40890 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GJU35_40900 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GJU35_40920 ENOG4108HMN Caspase domain GJU35_40925 ENOG4106NZI LysR family Transcriptional regulator GJU35_40955 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GJU35_41005 ENOG4105DCG PHP domain protein GJU35_41010 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GJU35_41035 ENOG4106A3M Cytochrome p-450 GJU35_41045 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GJU35_41065 ENOG4105C26 Dehydrogenase GJU35_41105 ENOG4105CUB amino acid GJU35_41125 ENOG4105CHF Glutathione S-transferase GJU35_41140 ENOG4106YKD Cytochrome p-450 GJU35_41155 ENOG4107XEY Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GJU35_41175 ENOG4105CPC Aldo Keto reductase GJU35_41210 ENOG4105CNT hydrolase family 2 GJU35_41240 ENOG4105CJA serine threonine protein kinase GJU35_41250 ENOG41080XP Cbs domain GJU35_41295 ENOG4108UGD Serine Threonine protein kinase GJU35_41300 ENOG4108KC1 acyl-Coa dehydrogenase GJU35_41350 ENOG4105XRQ Xanthine dehydrogenase accessory factor GJU35_41390 ENOG4107TXC Transcriptional regulator GJU35_41410 ENOG4107EMZ glycosyl transferase family GJU35_41435 ENOG4105C6X Major Facilitator GJU35_41450 ENOG4108MES Periplasmic binding protein GJU35_41455 ENOG4105E0A ABC, transporter GJU35_41460 ENOG4105TVJ transport system, permease GJU35_41465 ENOG4105DQ5 transport system permease protein GJU35_41495 ENOG4105PDP Short chain dehydrogenase GJU35_41500 ENOG4105CHR reductase GJU35_41520 ENOG4107FKK extracellular solute-binding protein family 1 GJU35_41525 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GJU35_41530 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GJU35_41535 ENOG4105E2R ROK family GJU35_41555 ENOG4105C87 Aminotransferase class I and II GJU35_41570 ENOG4105DDC Oxidoreductase domain protein GJU35_41580 ENOG41067SE Tetr family transcriptional regulator GJU35_41635 ENOG41066F8 ROK family GJU35_41645 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component GJU35_41650 ENOG4105DRS transport system, permease GJU35_41670 ENOG4105CS9 pantothenic acid kinase GJU35_41705 ENOG4105D9G High-affinity GJU35_41755 ENOG4108FN7 Aldo keto reductase GJU35_41785 ENOG4105EUB pirin domain protein GJU35_41795 ENOG4105ECQ AraC Family Transcriptional Regulator GJU35_41830 ENOG4105C7W Xanthine dehydrogenase GJU35_41835 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding GJU35_41840 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit GJU35_41850 ENOG4105QCJ Lipoprotein GJU35_41885 ENOG4107SVN transposase GJU35_41895 ENOG4105MSY salicylate hydroxylase GJU35_41910 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GJU35_41920 ENOG4105CSH Transporter GJU35_41925 ENOG4105HSS phospholipase C GJU35_41945 ENOG4108HMN Caspase domain GJU35_41945 ENOG4108HMN Caspase domain GJU35_41960 ENOG4105C4C beta-galactosidase GJU35_41995 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B GJU35_42030 ENOG4107QRI Phosphoketolase GJU35_42045 ENOG4105F1A Pyruvate formate-lyase GJU35_42060 ENOG4105C0A alcohol dehydrogenase GJU35_42100 ENOG4105CD5 CoA-binding domain protein GJU35_42125 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GJU35_42145 ENOG4105WN5 stage II sporulation protein GJU35_42150 ENOG4105E2A Dehydrogenase GJU35_42185 ENOG4105CPC Aldo Keto reductase GJU35_42200 ENOG4105E6M Sulphatase-modifying factor protein GJU35_42320 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GJU35_42330 ENOG4105BZU Histidine kinase GJU35_42335 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GJU35_42365 ENOG4105C5I Dehydrogenase GJU35_42420 ENOG410834F Transcriptional regulator GJU35_42430 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GJU35_42440 ENOG4105CSR polyphosphate kinase 2 GJU35_42455 ENOG4105C3M thioredoxin reductase GJU35_42475 ENOG4105C5X domain protein GJU35_42495 ENOG4105K78 MarR family Transcriptional regulator GJU35_42510 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GJU35_42515 ENOG4105BZU Histidine kinase GJU35_42550 ENOG4105E8G Major facilitator Superfamily GJU35_42560 ENOG4105CXN decarboxylase GJU35_42585 ENOG4108TM9 integral membrane protein GJU35_42605 ENOG4105CEP NADH dehydrogenase GJU35_42620 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GJU35_42625 ENOG4105FUA antagonist GJU35_42630 ENOG4107MMM Anti-sigma-factor antagonist GJU35_42665 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) GJU35_42670 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GJU35_42675 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) GJU35_42685 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) GJU35_42735 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GJU35_42760 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) GJU35_42765 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GJU35_42775 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_42790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GJU35_42825 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GJU35_42835 ENOG4108HKT sucrose-6-phosphate hydrolase GJU35_42870 ENOG4105BZU Histidine kinase GJU35_42880 ENOG4107RTD sua5 ycio yrdc ywlc family protein GJU35_42885 ENOG4107SWG transcriptional regulator MERR family GJU35_42905 ENOG4105EBM Alpha Beta Hydrolase Fold protein GJU35_42930 ENOG4105F0K SARP family transcriptional regulator GJU35_42955 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GJU35_42960 ENOG4105EHG Permease protein GJU35_42975 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_42980 ENOG4105BZU Histidine kinase GJU35_42985 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GJU35_42995 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GJU35_43000 ENOG4105CYW agmatinase GJU35_43015 ENOG4107QN1 sodium solute GJU35_43020 ENOG4108YYC ycei family GJU35_43095 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein GJU35_43105 ENOG4105CEP NADH dehydrogenase GJU35_43115 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GJU35_43125 ENOG4108JQ7 (ABC) transporter GJU35_43130 ENOG4105C3U ABC transporter GJU35_43145 ENOG4105DEF Extracellular solute-binding protein, family 5 GJU35_43150 ENOG4105KVH Transcriptional regulator GJU35_43185 ENOG4107UH8 sugar kinase GJU35_43190 ENOG4105CDA abc transporter atp-binding protein GJU35_43195 ENOG4105DRP amino acid AbC transporter GJU35_43210 ENOG41069M3 Transcriptional regulator GJU35_43245 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GJU35_43275 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase GJU35_43290 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GJU35_43300 ENOG41062IR nudix hydrolase GJU35_43305 ENOG4105EYF MMPL domain protein GJU35_43310 ENOG4105BZU Histidine kinase GJU35_43325 ENOG4108KPJ rna polymerase sigma factor GJU35_43360 ENOG4105VUN Transcriptional regulator GJU35_43365 ENOG4105WH1 Two component transcriptional regulator luxr family GJU35_43370 ENOG4105BZU Histidine kinase GJU35_43395 ENOG4105C5H ABC transporter GJU35_43405 ENOG4105DYW oxidoreductase GJU35_43410 ENOG4105JAB phenazine biosynthesis protein, phzf family GJU35_43440 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GJU35_43445 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GJU35_43450 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GJU35_43480 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GJU35_43485 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GJU35_43505 ENOG4105T1M mycothiol conjugate amidase mca GJU35_43565 ENOG4105KVH Transcriptional regulator GJU35_43615 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GJU35_43660 ENOG4105EHG Permease protein GJU35_43665 ENOG4105E0A ABC, transporter GJU35_43680 ENOG4105KVH Transcriptional regulator GJU35_43690 ENOG4105EB3 Histidine kinase GJU35_43695 ENOG4105E3W Two component transcriptional regulator (Winged helix family GJU35_43710 ENOG4105C19 ABC transporter GJU35_43715 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GJU35_43720 ENOG4105ETE Transcriptional regulator (LacI family GJU35_43735 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component GJU35_43765 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GJU35_43770 ENOG4108IND Tetr family transcriptional regulator GJU35_43800 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GJU35_43805 ENOG4108KPJ rna polymerase sigma factor GJU35_43820 ENOG4108KPJ rna polymerase sigma factor GJU35_43860 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GJU35_43915 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) GJU35_44035 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GJU35_44075 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GJU35_44105 ENOG4105CHR reductase GJU35_44110 ENOG4107RSM transcriptional regulator GJU35_44140 ENOG4106R7G Glycoside hydrolase family 5 GJU35_44285 ENOG4105D7V transposase GJU35_44290 ENOG4107S9F NmrA family GJU35_44305 ENOG4107QPV Serine Threonine protein kinase GJU35_44370 ENOG4105ETE Transcriptional regulator (LacI family GJU35_44375 ENOG4107TTA Xylose isomerase domain protein TIM barrel GJU35_44385 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GJU35_44390 ENOG4107QP6 Xylose isomerase domain protein TIM barrel GJU35_44410 ENOG4108VHC Short-chain dehydrogenase reductase Sdr GJU35_44415 ENOG41060BG Tetr family transcriptional regulator GJU35_44425 ENOG4105C26 Dehydrogenase GJU35_44430 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GJU35_44445 ENOG4105D5G Transposase GJU35_44455 ENOG4105C1J atp-dependent rna helicase GJU35_44460 ENOG4105F27 Major Facilitator GJU35_44625 ENOG4105E98 transcriptional regulator DeoR family GJU35_44630 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) GJU35_44635 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate GJU35_44645 ENOG4105CPQ Dehydrogenase GJU35_44695 ENOG4105CEY Amp-dependent synthetase and ligase GJU35_44705 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GJU35_44715 ENOG4105CHR reductase GJU35_44730 ENOG4105DYW oxidoreductase GJU35_44740 ENOG4105C1G acyl-Coa dehydrogenase GJU35_44745 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GJU35_44750 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GJU35_44755 ENOG41067SE Tetr family transcriptional regulator GJU35_44780 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GJU35_44835 ENOG4105ETE Transcriptional regulator (LacI family GJU35_44845 ENOG4108IG5 Transcriptional regulator GJU35_44870 ENOG4108IG5 Transcriptional regulator