locus-tag	class	description
SPRI_0005	COG0305	Participates in initiation and elongation during chromosome replication
SPRI_0017	COG0420	3'-5' exonuclease activity
SPRI_0018	COG0419	ATPase involved in DNA repair
SPRI_0037	COG0419	ATPase involved in DNA repair
SPRI_0038	COG0420	3'-5' exonuclease activity
SPRI_0054	COG0305	Participates in initiation and elongation during chromosome replication
SPRI_0055	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SPRI_0067	COG2318	DinB family
SPRI_0072	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SPRI_0077	COG0395	ABC-type sugar transport system, permease component
SPRI_0084	COG1278	Cold shock
SPRI_0091	COG0789	Transcriptional regulator
SPRI_0094	COG1695	Transcriptional regulator
SPRI_0097	COG1309	transcriptional regulator
SPRI_0112	COG4941	Belongs to the sigma-70 factor family
SPRI_0113	COG3795	YCII-related domain
SPRI_0114	COG2207	Transcriptional regulator
SPRI_0115	COG2223	nitrite transmembrane transporter activity
SPRI_0118	COG0513	Belongs to the DEAD box helicase family
SPRI_0122	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SPRI_0125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPRI_0130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SPRI_0142	COG0110	maltose O-acetyltransferase activity
SPRI_0145	COG2132	Multicopper oxidase
SPRI_0150	COG0134	indole-3-glycerol-phosphate synthase activity
SPRI_0152	COG1960	acyl-CoA dehydrogenase activity
SPRI_0153	COG0662	Cupin 2, conserved barrel domain protein
SPRI_0154	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SPRI_0157	COG2030	dehydratase
SPRI_0159	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_0160	COG0156	8-amino-7-oxononanoate synthase activity
SPRI_0163	COG2072	flavoprotein involved in K transport
SPRI_0166	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPRI_0169	COG0596	Alpha beta hydrolase
SPRI_0180	COG1410	methionine synthase
SPRI_0180	COG0646	methionine synthase
SPRI_0182	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SPRI_0188	COG3251	PFAM MbtH domain protein
SPRI_0192	COG1024	Enoyl-CoA hydratase
SPRI_0194	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPRI_0195	COG2197	response regulator
SPRI_0203	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_0211	COG3265	gluconokinase activity
SPRI_0212	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPRI_0215	COG2706	6-phosphogluconolactonase activity
SPRI_0218	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPRI_0220	COG1063	alcohol dehydrogenase
SPRI_0223	COG0135	phosphoribosylanthranilate isomerase activity
SPRI_0225	COG1960	acyl-CoA dehydrogenase activity
SPRI_0226	COG0662	Cupin 2, conserved barrel domain protein
SPRI_0227	COG0159	tryptophan synthase activity
SPRI_0228	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SPRI_0230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPRI_0235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPRI_0240	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SPRI_0244	COG1024	Enoyl-CoA hydratase
SPRI_0246	COG3425	synthase
SPRI_0247	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_0262	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPRI_0264	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPRI_0267	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_0271	COG1960	acyl-CoA dehydrogenase activity
SPRI_0278	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_0287	COG3629	intracellular signal transduction
SPRI_0293	COG3321	synthase
SPRI_0293	COG4221	oxidoreductase activity
SPRI_0293	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_0293	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPRI_0294	COG1024	Enoyl-CoA hydratase
SPRI_0296	COG3425	synthase
SPRI_0297	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_0298	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_0299	COG3321	synthase
SPRI_0299	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_0299	COG4221	oxidoreductase activity
SPRI_0299	COG0300	oxidoreductase activity
SPRI_0300	COG4221	oxidoreductase activity
SPRI_0300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_0300	COG0300	oxidoreductase activity
SPRI_0300	COG3321	synthase
SPRI_0301	COG0022	dehydrogenase e1 component
SPRI_0303	COG2890	protein-(glutamine-N5) methyltransferase activity
SPRI_0304	COG1605	Chorismate mutase
SPRI_0305	COG0287	Prephenate dehydrogenase
SPRI_0306	COG0512	Glutamine amidotransferase of anthranilate synthase
SPRI_0306	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPRI_0307	COG2124	cytochrome p450
SPRI_0308	COG2423	ornithine cyclodeaminase activity
SPRI_0309	COG1021	2,3-dihydroxybenzoate-AMP ligase
SPRI_0310	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPRI_0312	COG0477	Major facilitator Superfamily
SPRI_0314	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPRI_0325	COG0789	Transcriptional regulator
SPRI_0327	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SPRI_0332	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SPRI_0336	COG0531	amino acid
SPRI_0337	COG0667	Aldo Keto reductase
SPRI_0349	COG0277	FAD linked oxidase domain protein
SPRI_0350	COG1597	lipid kinase activity
SPRI_0352	COG0346	lactoylglutathione lyase activity
SPRI_0357	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_0359	COG1982	Orn Lys Arg decarboxylase major
SPRI_0367	COG1609	Transcriptional regulator
SPRI_0376	COG0463	Glycosyl transferase, family 2
SPRI_0379	COG1309	transcriptional regulator
SPRI_0381	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_0382	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_0389	COG4770	biotin carboxylase activity
SPRI_0392	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPRI_0394	COG1309	transcriptional regulator
SPRI_0396	COG1309	transcriptional regulator
SPRI_0398	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_0400	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_0401	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_0403	COG2030	dehydratase
SPRI_0404	COG0183	Belongs to the thiolase family
SPRI_0407	COG1309	transcriptional regulator
SPRI_0409	COG1024	Enoyl-CoA hydratase
SPRI_0410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPRI_0415	COG0804	urea catabolic process
SPRI_0422	COG2226	methyltransferase
SPRI_0426	COG3693	PFAM glycoside hydrolase, family 10
SPRI_0436	COG1309	transcriptional regulator
SPRI_0444	COG0765	amino acid transport
SPRI_0445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPRI_0447	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPRI_0447	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPRI_0449	COG2814	Major facilitator Superfamily
SPRI_0455	COG0583	DNA-binding transcription factor activity
SPRI_0456	COG0156	8-amino-7-oxononanoate synthase activity
SPRI_0457	COG1063	alcohol dehydrogenase
SPRI_0459	COG2018	Roadblock/LC7 domain
SPRI_0470	COG3239	Fatty acid desaturase
SPRI_0471	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPRI_0477	COG1124	(ABC) transporter
SPRI_0478	COG0444	Belongs to the ABC transporter superfamily
SPRI_0479	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPRI_0480	COG0601	transmembrane transport
SPRI_0482	COG1960	acyl-CoA dehydrogenase activity
SPRI_0483	COG1960	acyl-CoA dehydrogenase activity
SPRI_0489	COG3458	cephalosporin-C deacetylase activity
SPRI_0494	COG4989	oxidoreductase activity
SPRI_0500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SPRI_0501	COG1609	Transcriptional regulator
SPRI_0505	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SPRI_0507	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_0509	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPRI_0510	COG1349	DNA-binding transcription factor activity
SPRI_0512	COG0673	inositol 2-dehydrogenase activity
SPRI_0514	COG1473	amidohydrolase
SPRI_0516	COG1309	transcriptional regulator
SPRI_0520	COG3540	Alkaline phosphatase
SPRI_0521	COG0300	oxidoreductase activity
SPRI_0523	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SPRI_0527	COG2208	phosphoserine phosphatase activity
SPRI_0531	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SPRI_0534	COG1090	epimerase
SPRI_0536	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPRI_0543	COG1874	Beta-galactosidase
SPRI_0543	COG0366	Alpha amylase catalytic
SPRI_0545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPRI_0546	COG1132	(ABC) transporter
SPRI_0548	COG1175	transmembrane transport
SPRI_0551	COG1609	Transcriptional regulator
SPRI_0555	COG1733	regulation of RNA biosynthetic process
SPRI_0557	COG0181	hydroxymethylbilane synthase activity
SPRI_0558	COG1032	radical SAM domain protein
SPRI_0560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SPRI_0561	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPRI_0565	COG1609	Transcriptional regulator
SPRI_0566	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPRI_0568	COG1129	ABC transporter
SPRI_0569	COG1879	ABC-type sugar transport system periplasmic component
SPRI_0572	COG1609	Transcriptional regulator
SPRI_0584	COG1940	carbohydrate kinase activity
SPRI_0587	COG0395	ABC-type sugar transport system, permease component
SPRI_0588	COG2723	6-phospho-beta-galactosidase activity
SPRI_0589	COG0366	Alpha amylase catalytic
SPRI_0590	COG0395	ABC-type sugar transport system, permease component
SPRI_0591	COG1175	transmembrane transport
SPRI_0592	COG1653	transport
SPRI_0596	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SPRI_0598	COG2255	four-way junction helicase activity
SPRI_0601	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_0609	COG0494	nUDIX hydrolase
SPRI_0613	COG1619	proteins homologs of microcin C7 resistance protein MccF
SPRI_0614	COG0328	RNA-DNA hybrid ribonuclease activity
SPRI_0625	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_0626	COG2072	flavoprotein involved in K transport
SPRI_0633	COG1733	regulation of RNA biosynthetic process
SPRI_0644	COG0583	DNA-binding transcription factor activity
SPRI_0654	COG0598	Magnesium transport protein CorA
SPRI_0655	COG3226	Transcriptional regulator
SPRI_0656	COG0110	maltose O-acetyltransferase activity
SPRI_0659	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SPRI_0672	COG0523	cobalamin synthesis protein
SPRI_0676	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPRI_0677	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPRI_0678	COG0640	Transcriptional regulator
SPRI_0679	COG0346	lactoylglutathione lyase activity
SPRI_0692	COG0455	bacterial-type flagellum organization
SPRI_0696	COG3387	PFAM Glycoside hydrolase 15-related
SPRI_0697	COG1595	DNA-templated transcription, initiation
SPRI_0700	COG0148	phosphopyruvate hydratase activity
SPRI_0705	COG0235	Class ii aldolase
SPRI_0706	COG3395	kinase activity
SPRI_0707	COG0473	3-isopropylmalate dehydrogenase activity
SPRI_0708	COG1082	Xylose isomerase domain protein TIM barrel
SPRI_0711	COG2851	Citrate transporter
SPRI_0724	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPRI_0728	COG3572	ergothioneine biosynthetic process
SPRI_0729	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPRI_0730	COG0121	glutamine amidotransferase
SPRI_0731	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SPRI_0736	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPRI_0738	COG1175	transmembrane transport
SPRI_0740	COG2188	Transcriptional regulator
SPRI_0742	COG4585	Histidine kinase
SPRI_0743	COG2197	response regulator
SPRI_0745	COG2409	Drug exporters of the RND superfamily
SPRI_0746	COG2188	Transcriptional regulator
SPRI_0747	COG3360	Dodecin
SPRI_0749	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPRI_0752	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPRI_0753	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SPRI_0754	COG1053	succinate dehydrogenase
SPRI_0756	COG0583	DNA-binding transcription factor activity
SPRI_0760	COG2267	carboxylic ester hydrolase activity
SPRI_0770	COG3275	phosphorelay sensor kinase activity
SPRI_0771	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPRI_0776	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPRI_0777	COG3618	amidohydrolase
SPRI_0792	COG1063	alcohol dehydrogenase
SPRI_0793	COG0395	ABC-type sugar transport system, permease component
SPRI_0797	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPRI_0800	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SPRI_0801	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_0803	COG3246	L-lysine catabolic process to acetate
SPRI_0805	COG2175	clavaminate synthase activity
SPRI_0806	COG2271	Major facilitator Superfamily
SPRI_0808	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPRI_0810	COG1796	DNA polymerase
SPRI_0810	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SPRI_0812	COG3866	Pectate lyase
SPRI_0814	COG0456	acetyltransferase
SPRI_0818	COG3655	Transcriptional regulator
SPRI_0821	COG1846	Transcriptional regulator
SPRI_0822	COG1733	regulation of RNA biosynthetic process
SPRI_0830	COG0284	orotidine-5'-phosphate decarboxylase activity
SPRI_0837	COG1595	DNA-templated transcription, initiation
SPRI_0841	COG3629	intracellular signal transduction
SPRI_0841	COG3903	Transcriptional regulator
SPRI_0846	COG2207	Transcriptional regulator
SPRI_0846	COG3708	Transcriptional regulator
SPRI_0849	COG1881	PFAM PEBP family protein
SPRI_0850	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPRI_0853	COG1960	acyl-CoA dehydrogenase activity
SPRI_0855	COG1733	regulation of RNA biosynthetic process
SPRI_0862	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SPRI_0865	COG1802	Transcriptional regulator
SPRI_0868	COG1175	transmembrane transport
SPRI_0869	COG0395	ABC-type sugar transport system, permease component
SPRI_0873	COG1653	transport
SPRI_0874	COG2755	lipolytic protein G-D-S-L family
SPRI_0875	COG3866	Pectate lyase
SPRI_0876	COG4677	pectinesterase activity
SPRI_0879	COG1595	DNA-templated transcription, initiation
SPRI_0881	COG5297	Belongs to the glycosyl hydrolase family 6
SPRI_0883	COG5297	Belongs to the glycosyl hydrolase family 6
SPRI_0883	COG4733	cellulase activity
SPRI_0894	COG0754	glutathionylspermidine amidase activity
SPRI_0901	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPRI_0901	COG0515	serine threonine protein kinase
SPRI_0903	COG1609	Transcriptional regulator
SPRI_0904	COG3896	Chloramphenicol phosphotransferase-like protein
SPRI_0906	COG0395	ABC-type sugar transport system, permease component
SPRI_0907	COG1175	transmembrane transport
SPRI_0910	COG1070	Carbohydrate kinase
SPRI_0920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPRI_0930	COG1120	ATPase activity
SPRI_0931	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_0932	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_0934	COG1132	(ABC) transporter
SPRI_0937	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPRI_0938	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SPRI_0944	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPRI_0945	COG3959	Transketolase, thiamine diphosphate binding domain
SPRI_0946	COG3958	Transketolase
SPRI_0952	COG3507	Belongs to the glycosyl hydrolase 43 family
SPRI_0954	COG1116	anion transmembrane transporter activity
SPRI_0956	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPRI_0964	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPRI_0971	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPRI_0973	COG2755	lipolytic protein G-D-S-L family
SPRI_0974	COG0739	heme binding
SPRI_0982	COG1657	PFAM Prenyltransferase squalene oxidase
SPRI_0984	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SPRI_0986	COG1562	ergosterol biosynthetic process
SPRI_0987	COG1388	LysM domain
SPRI_0987	COG1134	teichoic acid transport
SPRI_0991	COG0371	Dehydrogenase
SPRI_0997	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SPRI_1000	COG1024	Enoyl-CoA hydratase
SPRI_1002	COG4977	sequence-specific DNA binding
SPRI_1007	COG2183	response to ionizing radiation
SPRI_1012	COG4608	Belongs to the ABC transporter superfamily
SPRI_1013	COG0444	Belongs to the ABC transporter superfamily
SPRI_1014	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPRI_1019	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SPRI_1025	COG0395	ABC-type sugar transport system, permease component
SPRI_1029	COG3568	Endonuclease Exonuclease Phosphatase
SPRI_1034	COG0789	Transcriptional regulator
SPRI_1036	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPRI_1036	COG1024	Enoyl-CoA hydratase
SPRI_1037	COG0183	Belongs to the thiolase family
SPRI_1038	COG1960	acyl-CoA dehydrogenase activity
SPRI_1040	COG3268	Saccharopine dehydrogenase
SPRI_1043	COG1515	deoxyribonuclease V activity
SPRI_1048	COG0488	(ABC) transporter
SPRI_1050	COG3415	Transposase
SPRI_1050	COG2801	Transposase and inactivated derivatives
SPRI_1060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPRI_1062	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_1067	COG3285	dna ligase
SPRI_1067	COG1793	dna ligase
SPRI_1068	COG1793	dna ligase
SPRI_1080	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SPRI_1087	COG3012	SEC-C Motif Domain Protein
SPRI_1089	COG1486	melibiose metabolic process
SPRI_1095	COG0431	NADPH-dependent FMN reductase
SPRI_1099	COG0477	Major facilitator Superfamily
SPRI_1100	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SPRI_1106	COG2318	DinB family
SPRI_1108	COG1396	sequence-specific DNA binding
SPRI_1123	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPRI_1124	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SPRI_1125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPRI_1126	COG0583	DNA-binding transcription factor activity
SPRI_1129	COG0477	Major facilitator Superfamily
SPRI_1135	COG2855	membrane
SPRI_1137	COG0583	DNA-binding transcription factor activity
SPRI_1140	COG0475	glutathione-regulated potassium exporter activity
SPRI_1144	COG0789	Transcriptional regulator
SPRI_1146	COG0789	Transcriptional regulator
SPRI_1150	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SPRI_1150	COG0515	serine threonine protein kinase
SPRI_1157	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPRI_1166	COG1132	(ABC) transporter
SPRI_1174	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SPRI_1191	COG3401	FG-GAP repeat protein
SPRI_1198	COG1595	DNA-templated transcription, initiation
SPRI_1199	COG1802	Transcriptional regulator
SPRI_1200	COG3938	Belongs to the proline racemase family
SPRI_1203	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPRI_1213	COG4977	sequence-specific DNA binding
SPRI_1218	COG1869	D-ribose catabolic process
SPRI_1219	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPRI_1220	COG1879	ABC-type sugar transport system periplasmic component
SPRI_1221	COG1129	ABC transporter
SPRI_1225	COG4325	translation initiation factor activity
SPRI_1228	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_1230	COG0045	succinate-CoA ligase (ADP-forming) activity
SPRI_1232	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPRI_1233	COG0045	succinate-CoA ligase (ADP-forming) activity
SPRI_1233	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPRI_1233	COG1042	CoA-binding domain protein
SPRI_1234	COG2223	nitrite transmembrane transporter activity
SPRI_1236	COG0789	Transcriptional regulator
SPRI_1244	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SPRI_1248	COG0673	inositol 2-dehydrogenase activity
SPRI_1249	COG4213	ABC transporter substrate-binding protein
SPRI_1250	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPRI_1251	COG1129	ABC transporter
SPRI_1252	COG1940	carbohydrate kinase activity
SPRI_1257	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPRI_1258	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SPRI_1259	COG3383	formate dehydrogenase (NAD+) activity
SPRI_1262	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SPRI_1264	COG0477	Major facilitator Superfamily
SPRI_1275	COG0656	L-ascorbic acid biosynthetic process
SPRI_1280	COG2154	pterin-4-alpha-carbinolamine dehydratase
SPRI_1282	COG1793	dna ligase
SPRI_1290	COG0531	amino acid
SPRI_1292	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPRI_1297	COG2226	methyltransferase
SPRI_1302	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SPRI_1303	COG1619	proteins homologs of microcin C7 resistance protein MccF
SPRI_1304	COG4946	Tricorn protease homolog
SPRI_1304	COG1506	peptidase
SPRI_1304	COG0823	Involved in the tonB-independent uptake of proteins
SPRI_1305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPRI_1306	COG2362	D-Aminopeptidase
SPRI_1307	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SPRI_1308	COG1834	amidinotransferase
SPRI_1317	COG2814	Major facilitator Superfamily
SPRI_1322	COG0659	secondary active sulfate transmembrane transporter activity
SPRI_1324	COG0745	RESPONSE REGULATOR receiver
SPRI_1325	COG2205	protein histidine kinase activity
SPRI_1326	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPRI_1328	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPRI_1334	COG1960	acyl-CoA dehydrogenase activity
SPRI_1335	COG0688	phosphatidylethanolamine metabolic process
SPRI_1340	COG0559	Belongs to the binding-protein-dependent transport system permease family
SPRI_1343	COG1929	Belongs to the glycerate kinase type-1 family
SPRI_1344	COG0494	nUDIX hydrolase
SPRI_1346	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SPRI_1347	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPRI_1353	COG0483	inositol monophosphate 1-phosphatase activity
SPRI_1354	COG0405	Gamma-glutamyltransferase
SPRI_1356	COG2986	histidine ammonia-lyase
SPRI_1358	COG1846	Transcriptional regulator
SPRI_1360	COG2197	response regulator
SPRI_1361	COG4585	Histidine kinase
SPRI_1366	COG0300	oxidoreductase activity
SPRI_1368	COG1953	Uracil, thiamine, allantoin
SPRI_1370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPRI_1371	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SPRI_1377	COG0405	Gamma-glutamyltransferase
SPRI_1380	COG1126	abc transporter atp-binding protein
SPRI_1384	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPRI_1385	COG1132	(ABC) transporter
SPRI_1404	COG0739	heme binding
SPRI_1413	COG1940	carbohydrate kinase activity
SPRI_1417	COG1879	ABC-type sugar transport system periplasmic component
SPRI_1419	COG0673	inositol 2-dehydrogenase activity
SPRI_1423	COG2197	response regulator
SPRI_1429	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_1430	COG4266	Belongs to the allantoicase family
SPRI_1431	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPRI_1432	COG1414	Transcriptional regulator
SPRI_1433	COG3537	Alpha-1,2-mannosidase
SPRI_1437	COG2197	response regulator
SPRI_1445	COG2267	carboxylic ester hydrolase activity
SPRI_1447	COG1733	regulation of RNA biosynthetic process
SPRI_1449	COG2226	methyltransferase
SPRI_1450	COG0154	amidase activity
SPRI_1453	COG1733	regulation of RNA biosynthetic process
SPRI_1469	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPRI_1477	COG4977	sequence-specific DNA binding
SPRI_1479	COG0477	Major facilitator Superfamily
SPRI_1481	COG0714	Associated with various cellular activities
SPRI_1484	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPRI_1486	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPRI_1493	COG0628	permease
SPRI_1498	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPRI_1498	COG3291	Pkd domain containing protein
SPRI_1506	COG2367	Beta-lactamase
SPRI_1507	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SPRI_1512	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPRI_1512	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPRI_1515	COG2208	phosphoserine phosphatase activity
SPRI_1521	COG2318	DinB family
SPRI_1523	COG2340	Cysteine-rich secretory protein family
SPRI_1524	COG0515	serine threonine protein kinase
SPRI_1524	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SPRI_1525	COG2205	protein histidine kinase activity
SPRI_1526	COG0745	RESPONSE REGULATOR receiver
SPRI_1529	COG3866	Pectate lyase
SPRI_1531	COG2272	Belongs to the type-B carboxylesterase lipase family
SPRI_1540	COG2249	NAD(P)H dehydrogenase (quinone) activity
SPRI_1546	COG2356	endonuclease I
SPRI_1547	COG1063	alcohol dehydrogenase
SPRI_1549	COG2233	PERMEase
SPRI_1551	COG2233	PERMEase
SPRI_1553	COG2351	hydroxyisourate hydrolase activity
SPRI_1561	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SPRI_1571	COG3622	Belongs to the hyi family
SPRI_1572	COG2084	Dehydrogenase
SPRI_1573	COG0753	catalase activity
SPRI_1575	COG3960	tartronate-semialdehyde synthase activity
SPRI_1578	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_1579	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPRI_1580	COG2197	response regulator
SPRI_1582	COG2326	polyphosphate kinase activity
SPRI_1583	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPRI_1589	COG1595	DNA-templated transcription, initiation
SPRI_1594	COG2252	PERMEase
SPRI_1595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SPRI_1599	COG1132	(ABC) transporter
SPRI_1606	COG1120	ATPase activity
SPRI_1607	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_1608	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_1615	COG1802	Transcriptional regulator
SPRI_1619	COG0028	Belongs to the TPP enzyme family
SPRI_1622	COG1404	Belongs to the peptidase S8 family
SPRI_1625	COG1162	GTPase activity
SPRI_1627	COG1796	DNA polymerase
SPRI_1627	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SPRI_1630	COG2304	oxidoreductase activity
SPRI_1642	COG0475	glutathione-regulated potassium exporter activity
SPRI_1646	COG1063	alcohol dehydrogenase
SPRI_1647	COG2130	NADP-dependent
SPRI_1648	COG1733	regulation of RNA biosynthetic process
SPRI_1649	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SPRI_1651	COG5002	protein histidine kinase activity
SPRI_1652	COG0745	RESPONSE REGULATOR receiver
SPRI_1656	COG1960	acyl-CoA dehydrogenase activity
SPRI_1660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SPRI_1662	COG0175	sulfate reduction
SPRI_1667	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPRI_1668	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SPRI_1669	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPRI_1671	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SPRI_1672	COG2132	Multicopper oxidase
SPRI_1675	COG2409	Drug exporters of the RND superfamily
SPRI_1680	COG1175	transmembrane transport
SPRI_1687	COG0583	DNA-binding transcription factor activity
SPRI_1688	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPRI_1696	COG0346	lactoylglutathione lyase activity
SPRI_1697	COG2706	6-phosphogluconolactonase activity
SPRI_1710	COG3469	chitinase activity
SPRI_1714	COG2318	DinB family
SPRI_1718	COG2197	response regulator
SPRI_1719	COG4585	Histidine kinase
SPRI_1732	COG1073	alpha beta
SPRI_1733	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
SPRI_1733	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPRI_1740	COG1131	(ABC) transporter
SPRI_1741	COG4585	Histidine kinase
SPRI_1742	COG2197	response regulator
SPRI_1744	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPRI_1745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SPRI_1752	COG1764	response to oxidative stress
SPRI_1753	COG1846	Transcriptional regulator
SPRI_1754	COG0395	ABC-type sugar transport system, permease component
SPRI_1755	COG1175	transmembrane transport
SPRI_1757	COG0366	Alpha amylase catalytic
SPRI_1758	COG1653	transport
SPRI_1760	COG1136	(ABC) transporter
SPRI_1769	COG4152	abc transporter atp-binding protein
SPRI_1775	COG4977	sequence-specific DNA binding
SPRI_1778	COG3220	belongs to the UPF0276 family
SPRI_1780	COG0596	Alpha beta hydrolase
SPRI_1784	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPRI_1786	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SPRI_1790	COG0583	DNA-binding transcription factor activity
SPRI_1792	COG0183	Belongs to the thiolase family
SPRI_1795	COG0438	transferase activity, transferring glycosyl groups
SPRI_1797	COG0438	transferase activity, transferring glycosyl groups
SPRI_1802	COG0531	amino acid
SPRI_1803	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPRI_1804	COG4214	carbohydrate transport
SPRI_1806	COG4213	ABC transporter substrate-binding protein
SPRI_1807	COG1940	carbohydrate kinase activity
SPRI_1810	COG3226	Transcriptional regulator
SPRI_1811	COG2267	carboxylic ester hydrolase activity
SPRI_1813	COG1175	transmembrane transport
SPRI_1818	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SPRI_1822	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPRI_1825	COG1959	2 iron, 2 sulfur cluster binding
SPRI_1829	COG2267	carboxylic ester hydrolase activity
SPRI_1838	COG1024	Enoyl-CoA hydratase
SPRI_1840	COG0531	amino acid
SPRI_1841	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SPRI_1853	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPRI_1856	COG2040	homocysteine
SPRI_1861	COG1799	cell septum assembly
SPRI_1865	COG0366	Alpha amylase catalytic
SPRI_1867	COG1175	transmembrane transport
SPRI_1868	COG2182	Extracellular solute-binding protein
SPRI_1869	COG1609	Transcriptional regulator
SPRI_1871	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPRI_1872	COG3833	ABC-type maltose transport systems, permease component
SPRI_1873	COG1175	transmembrane transport
SPRI_1877	COG3250	beta-galactosidase activity
SPRI_1877	COG5297	Belongs to the glycosyl hydrolase family 6
SPRI_1878	COG2723	6-phospho-beta-galactosidase activity
SPRI_1879	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_1880	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_1882	COG0859	PFAM glycosyl transferase family 9
SPRI_1883	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SPRI_1883	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SPRI_1884	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SPRI_1885	COG0438	transferase activity, transferring glycosyl groups
SPRI_1887	COG0859	PFAM glycosyl transferase family 9
SPRI_1888	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPRI_1890	COG2192	nodulation
SPRI_1891	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPRI_1893	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPRI_1898	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_1899	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_1902	COG2867	negative regulation of translational initiation
SPRI_1902	COG2226	methyltransferase
SPRI_1908	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SPRI_1927	COG2132	Multicopper oxidase
SPRI_1929	COG1830	Aldolase
SPRI_1930	COG1465	3-dehydroquinate synthase
SPRI_1931	COG2197	response regulator
SPRI_1941	COG0739	heme binding
SPRI_1941	COG0741	lytic transglycosylase activity
SPRI_1941	COG1196	nuclear chromosome segregation
SPRI_1948	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SPRI_1951	COG0477	Major facilitator Superfamily
SPRI_1952	COG0456	acetyltransferase
SPRI_1955	COG1984	allophanate hydrolase subunit 2
SPRI_1956	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SPRI_1957	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SPRI_1959	COG0640	Transcriptional regulator
SPRI_1962	COG2205	protein histidine kinase activity
SPRI_1963	COG0745	RESPONSE REGULATOR receiver
SPRI_1968	COG0513	Belongs to the DEAD box helicase family
SPRI_1969	COG1278	Cold shock
SPRI_1970	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SPRI_1976	COG3387	PFAM Glycoside hydrolase 15-related
SPRI_1978	COG0702	epimerase
SPRI_1987	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SPRI_1999	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPRI_2000	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SPRI_2004	COG0367	asparagine synthase
SPRI_2009	COG0438	transferase activity, transferring glycosyl groups
SPRI_2011	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SPRI_2014	COG4310	Domain of unknown function (DUF2172)
SPRI_2016	COG1215	transferase activity, transferring glycosyl groups
SPRI_2019	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SPRI_2026	COG0590	tRNA wobble adenosine to inosine editing
SPRI_2028	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPRI_2029	COG0531	amino acid
SPRI_2030	COG0569	domain protein
SPRI_2036	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPRI_2036	COG1136	(ABC) transporter
SPRI_2038	COG0756	dUTP diphosphatase activity
SPRI_2043	COG2205	protein histidine kinase activity
SPRI_2044	COG0745	RESPONSE REGULATOR receiver
SPRI_2059	COG1435	thymidine kinase activity
SPRI_2063	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPRI_2064	COG1802	Transcriptional regulator
SPRI_2065	COG0739	heme binding
SPRI_2067	COG0612	Peptidase, M16
SPRI_2068	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPRI_2073	COG3290	protein histidine kinase activity
SPRI_2075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPRI_2077	COG2197	response regulator
SPRI_2078	COG4585	Histidine kinase
SPRI_2079	COG0187	DNA topoisomerase II activity
SPRI_2082	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPRI_2083	COG1802	Transcriptional regulator
SPRI_2090	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPRI_2095	COG0488	(ABC) transporter
SPRI_2110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPRI_2112	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SPRI_2113	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SPRI_2115	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SPRI_2119	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPRI_2121	COG2205	protein histidine kinase activity
SPRI_2122	COG0745	RESPONSE REGULATOR receiver
SPRI_2123	COG1126	abc transporter atp-binding protein
SPRI_2124	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPRI_2125	COG0765	amino acid transport
SPRI_2126	COG0765	amino acid transport
SPRI_2134	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPRI_2136	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SPRI_2143	COG1201	RNA secondary structure unwinding
SPRI_2144	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPRI_2145	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_2148	COG1396	sequence-specific DNA binding
SPRI_2149	COG1058	Belongs to the CinA family
SPRI_2149	COG1546	Belongs to the CinA family
SPRI_2151	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPRI_2153	COG1674	ftsk spoiiie
SPRI_2155	COG2205	protein histidine kinase activity
SPRI_2155	COG0784	Response regulator, receiver
SPRI_2156	COG2208	phosphoserine phosphatase activity
SPRI_2156	COG2770	Histidine kinase
SPRI_2157	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SPRI_2158	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPRI_2159	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SPRI_2163	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SPRI_2164	COG0612	Peptidase, M16
SPRI_2165	COG1185	polyribonucleotide nucleotidyltransferase activity
SPRI_2166	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SPRI_2168	COG1674	ftsk spoiiie
SPRI_2172	COG1404	Belongs to the peptidase S8 family
SPRI_2176	COG0455	bacterial-type flagellum organization
SPRI_2178	COG0601	transmembrane transport
SPRI_2179	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPRI_2180	COG0444	Belongs to the ABC transporter superfamily
SPRI_2181	COG4608	Belongs to the ABC transporter superfamily
SPRI_2182	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SPRI_2185	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPRI_2186	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SPRI_2188	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SPRI_2191	COG0779	Required for maturation of 30S ribosomal subunits
SPRI_2195	COG0442	prolyl-tRNA aminoacylation
SPRI_2198	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SPRI_2199	COG0750	zinc metalloprotease
SPRI_2200	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SPRI_2205	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_2206	COG0697	spore germination
SPRI_2207	COG2508	Transcriptional regulator
SPRI_2213	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPRI_2214	COG1177	transmembrane transport
SPRI_2215	COG1176	ABC-type spermidine putrescine transport system, permease component I
SPRI_2216	COG3842	ATPase activity
SPRI_2217	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SPRI_2221	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SPRI_2224	COG4585	Histidine kinase
SPRI_2225	COG2197	response regulator
SPRI_2226	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPRI_2227	COG0300	oxidoreductase activity
SPRI_2229	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_2231	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SPRI_2232	COG1136	(ABC) transporter
SPRI_2235	COG3842	ATPase activity
SPRI_2238	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SPRI_2241	COG0575	Belongs to the CDS family
SPRI_2242	COG0233	cytoplasmic translational termination
SPRI_2243	COG0528	UMP kinase activity
SPRI_2244	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SPRI_2245	COG0052	Belongs to the universal ribosomal protein uS2 family
SPRI_2248	COG1191	sigma factor activity
SPRI_2250	COG0606	chelatase, subunit chli
SPRI_2251	COG0792	nuclease activity
SPRI_2253	COG1051	belongs to the nudix hydrolase family
SPRI_2254	COG0681	Belongs to the peptidase S26 family
SPRI_2255	COG0681	Belongs to the peptidase S26 family
SPRI_2257	COG0681	Belongs to the peptidase S26 family
SPRI_2258	COG0335	large ribosomal subunit rRNA binding
SPRI_2259	COG0336	Belongs to the RNA methyltransferase TrmD family
SPRI_2260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SPRI_2261	COG1837	Belongs to the UPF0109 family
SPRI_2262	COG0228	four-way junction DNA binding
SPRI_2264	COG0442	prolyl-tRNA aminoacylation
SPRI_2267	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SPRI_2273	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SPRI_2275	COG0477	Major facilitator Superfamily
SPRI_2276	COG1196	nuclear chromosome segregation
SPRI_2278	COG1254	Belongs to the acylphosphatase family
SPRI_2279	COG2340	Cysteine-rich secretory protein family
SPRI_2282	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPRI_2283	COG0571	ribonuclease III activity
SPRI_2284	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SPRI_2287	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SPRI_2288	COG0742	ribosomal rna small subunit methyltransferase
SPRI_2290	COG0326	Molecular chaperone. Has ATPase activity
SPRI_2292	COG1461	Dihydroxyacetone kinase
SPRI_2293	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPRI_2294	COG0351	phosphomethylpyrimidine kinase
SPRI_2298	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPRI_2299	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SPRI_2303	COG0776	regulation of translation
SPRI_2305	COG0066	3-isopropylmalate dehydratase activity
SPRI_2306	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SPRI_2307	COG1414	Transcriptional regulator
SPRI_2311	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPRI_2312	COG0179	Fumarylacetoacetate (FAA) hydrolase
SPRI_2314	COG5002	protein histidine kinase activity
SPRI_2315	COG2018	Roadblock/LC7 domain
SPRI_2319	COG2018	Roadblock/LC7 domain
SPRI_2325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPRI_2326	COG0366	Alpha amylase catalytic
SPRI_2326	COG1470	cell adhesion involved in biofilm formation
SPRI_2329	COG2353	YceI-like domain
SPRI_2332	COG1472	Belongs to the glycosyl hydrolase 3 family
SPRI_2333	COG1609	Transcriptional regulator
SPRI_2335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SPRI_2337	COG2957	Belongs to the agmatine deiminase family
SPRI_2338	COG0804	urea catabolic process
SPRI_2339	COG0832	Belongs to the urease beta subunit family
SPRI_2339	COG0831	urea catabolic process
SPRI_2341	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPRI_2342	COG0473	3-isopropylmalate dehydrogenase activity
SPRI_2344	COG1695	Transcriptional regulator
SPRI_2348	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_2349	COG0506	proline dehydrogenase activity
SPRI_2352	COG0477	Major facilitator Superfamily
SPRI_2355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SPRI_2356	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SPRI_2357	COG0440	acetolactate synthase activity
SPRI_2361	COG0667	Aldo Keto reductase
SPRI_2362	COG2133	pyrroloquinoline quinone binding
SPRI_2364	COG2197	response regulator
SPRI_2369	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPRI_2370	COG2409	Drug exporters of the RND superfamily
SPRI_2374	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPRI_2376	COG0154	amidase activity
SPRI_2377	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPRI_2379	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPRI_2381	COG4221	oxidoreductase activity
SPRI_2385	COG0482	sulfurtransferase activity
SPRI_2393	COG2860	membrane
SPRI_2394	COG4608	Belongs to the ABC transporter superfamily
SPRI_2395	COG0444	Belongs to the ABC transporter superfamily
SPRI_2398	COG0747	negative chemotaxis
SPRI_2402	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SPRI_2403	COG0509	glycine decarboxylation via glycine cleavage system
SPRI_2404	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SPRI_2405	COG1760	l-serine dehydratase
SPRI_2410	COG2197	response regulator
SPRI_2411	COG1132	(ABC) transporter
SPRI_2412	COG1132	(ABC) transporter
SPRI_2414	COG0515	serine threonine protein kinase
SPRI_2415	COG1024	Enoyl-CoA hydratase
SPRI_2419	COG2197	response regulator
SPRI_2420	COG4585	Histidine kinase
SPRI_2422	COG1131	(ABC) transporter
SPRI_2424	COG1132	(ABC) transporter
SPRI_2428	COG4585	Histidine kinase
SPRI_2429	COG2252	PERMEase
SPRI_2441	COG0058	SHG alpha-glucan phosphorylase activity
SPRI_2442	COG0366	Alpha amylase catalytic
SPRI_2445	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPRI_2446	COG3973	AAA domain
SPRI_2448	COG2205	protein histidine kinase activity
SPRI_2450	COG0745	RESPONSE REGULATOR receiver
SPRI_2452	COG1595	DNA-templated transcription, initiation
SPRI_2453	COG3118	belongs to the thioredoxin family
SPRI_2455	COG1301	dicarboxylic acid transport
SPRI_2456	COG3290	protein histidine kinase activity
SPRI_2457	COG4565	transcriptional regulatory protein
SPRI_2459	COG1175	transmembrane transport
SPRI_2460	COG0395	ABC-type sugar transport system, permease component
SPRI_2465	COG0205	6-phosphofructokinase activity
SPRI_2466	COG0857	belongs to the CobB CobQ family
SPRI_2466	COG0280	phosphate acetyltransferase
SPRI_2467	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SPRI_2470	COG2188	Transcriptional regulator
SPRI_2491	COG2205	protein histidine kinase activity
SPRI_2492	COG0745	RESPONSE REGULATOR receiver
SPRI_2495	COG0183	Belongs to the thiolase family
SPRI_2506	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SPRI_2507	COG1136	(ABC) transporter
SPRI_2509	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPRI_2512	COG4585	Histidine kinase
SPRI_2513	COG2197	response regulator
SPRI_2516	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SPRI_2517	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SPRI_2518	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SPRI_2519	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SPRI_2520	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPRI_2521	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SPRI_2522	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPRI_2526	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SPRI_2527	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPRI_2529	COG2890	protein-(glutamine-N5) methyltransferase activity
SPRI_2530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SPRI_2531	COG0254	rRNA binding
SPRI_2532	COG1316	TRANSCRIPTIONal
SPRI_2534	COG0083	homoserine kinase activity
SPRI_2535	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SPRI_2536	COG0460	homoserine dehydrogenase
SPRI_2537	COG0019	diaminopimelate decarboxylase activity
SPRI_2538	COG0018	arginyl-trna synthetase
SPRI_2563	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_2569	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SPRI_2570	COG3285	dna ligase
SPRI_2570	COG1793	dna ligase
SPRI_2576	COG0768	penicillin binding
SPRI_2583	COG0791	NLP P60 protein
SPRI_2583	COG3883	PFAM NLP P60 protein
SPRI_2592	COG1357	PFAM Pentapeptide repeats (8 copies)
SPRI_2593	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SPRI_2597	COG0745	RESPONSE REGULATOR receiver
SPRI_2598	COG2205	protein histidine kinase activity
SPRI_2599	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPRI_2599	COG0567	Dehydrogenase, E1 component
SPRI_2609	COG0604	alcohol dehydrogenase
SPRI_2610	COG3540	Alkaline phosphatase
SPRI_2614	COG0765	amino acid transport
SPRI_2615	COG1126	abc transporter atp-binding protein
SPRI_2616	COG4106	trans-aconitate 2-methyltransferase activity
SPRI_2628	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPRI_2629	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SPRI_2635	COG1597	lipid kinase activity
SPRI_2640	COG1472	Belongs to the glycosyl hydrolase 3 family
SPRI_2642	COG1175	transmembrane transport
SPRI_2644	COG2188	Transcriptional regulator
SPRI_2651	COG0242	peptide deformylase activity
SPRI_2654	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SPRI_2654	COG2199	diguanylate cyclase activity
SPRI_2655	COG5662	AntiSigma factor
SPRI_2656	COG1595	DNA-templated transcription, initiation
SPRI_2658	COG2135	peptidase activity
SPRI_2660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SPRI_2661	COG1162	GTPase activity
SPRI_2662	COG2076	Multidrug Resistance protein
SPRI_2664	COG0483	inositol monophosphate 1-phosphatase activity
SPRI_2666	COG0753	catalase activity
SPRI_2669	COG1615	UPF0182 protein
SPRI_2671	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPRI_2682	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SPRI_2690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPRI_2710	COG0513	Belongs to the DEAD box helicase family
SPRI_2713	COG1432	Conserved Protein
SPRI_2715	COG2095	MarC family integral membrane protein
SPRI_2719	COG0598	Magnesium transport protein CorA
SPRI_2726	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SPRI_2728	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPRI_2730	COG1595	DNA-templated transcription, initiation
SPRI_2733	COG1024	Enoyl-CoA hydratase
SPRI_2734	COG2818	Glycosylase
SPRI_2736	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPRI_2737	COG1611	Belongs to the LOG family
SPRI_2738	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPRI_2746	COG3209	COG3209 Rhs family protein
SPRI_2752	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SPRI_2756	COG4608	Belongs to the ABC transporter superfamily
SPRI_2758	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPRI_2759	COG0601	transmembrane transport
SPRI_2763	COG4608	Belongs to the ABC transporter superfamily
SPRI_2764	COG0444	Belongs to the ABC transporter superfamily
SPRI_2765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPRI_2766	COG0601	transmembrane transport
SPRI_2767	COG4166	transmembrane transport
SPRI_2776	COG1842	Phage shock protein A
SPRI_2787	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_2790	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SPRI_2791	COG0732	type I restriction modification DNA specificity domain
SPRI_2808	COG4974	Belongs to the 'phage' integrase family
SPRI_2809	COG0012	GTP binding
SPRI_2812	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SPRI_2814	COG1570	exodeoxyribonuclease VII activity
SPRI_2815	COG1722	exodeoxyribonuclease VII activity
SPRI_2816	COG0778	Nitroreductase
SPRI_2823	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SPRI_2823	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SPRI_2825	COG1595	DNA-templated transcription, initiation
SPRI_2827	COG0114	fumarate hydratase activity
SPRI_2830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPRI_2837	COG0450	alkyl hydroperoxide reductase
SPRI_2838	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPRI_2842	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SPRI_2843	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPRI_2844	COG0667	Aldo Keto reductase
SPRI_2850	COG2885	chlorophyll binding
SPRI_2859	COG0489	protein tyrosine kinase activity
SPRI_2868	COG2610	gluconate transmembrane transporter activity
SPRI_2869	COG0251	oxidation-reduction process
SPRI_2870	COG1414	Transcriptional regulator
SPRI_2873	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SPRI_2888	COG0438	transferase activity, transferring glycosyl groups
SPRI_2890	COG0728	peptidoglycan biosynthetic process
SPRI_2893	COG0438	transferase activity, transferring glycosyl groups
SPRI_2900	COG2890	protein-(glutamine-N5) methyltransferase activity
SPRI_2904	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SPRI_2906	COG0477	Major facilitator Superfamily
SPRI_2907	COG1309	transcriptional regulator
SPRI_2910	COG0463	Glycosyl transferase, family 2
SPRI_2913	COG1331	Highly conserved protein containing a thioredoxin domain
SPRI_2918	COG0583	DNA-binding transcription factor activity
SPRI_2921	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SPRI_2923	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SPRI_2926	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPRI_2928	COG1595	DNA-templated transcription, initiation
SPRI_2933	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPRI_2936	COG0488	(ABC) transporter
SPRI_2943	COG2986	histidine ammonia-lyase
SPRI_2945	COG1024	Enoyl-CoA hydratase
SPRI_2948	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPRI_2953	COG0424	maF-like protein
SPRI_2955	COG4770	biotin carboxylase activity
SPRI_2962	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPRI_2965	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_2969	COG1595	DNA-templated transcription, initiation
SPRI_2970	COG0745	RESPONSE REGULATOR receiver
SPRI_2971	COG2205	protein histidine kinase activity
SPRI_2976	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SPRI_2979	COG0583	DNA-binding transcription factor activity
SPRI_2980	COG2814	Major facilitator Superfamily
SPRI_2989	COG1473	amidohydrolase
SPRI_2989	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SPRI_2992	COG2089	acid synthase
SPRI_2995	COG1216	Glycosyl transferase, family 2
SPRI_3001	COG1595	DNA-templated transcription, initiation
SPRI_3013	COG0681	Belongs to the peptidase S26 family
SPRI_3028	COG2009	succinate dehydrogenase
SPRI_3030	COG1053	succinate dehydrogenase
SPRI_3031	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SPRI_3036	COG0596	Alpha beta hydrolase
SPRI_3039	COG1309	transcriptional regulator
SPRI_3040	COG1408	metallophosphoesterase
SPRI_3045	COG0180	Tryptophanyl-tRNA synthetase
SPRI_3046	COG1595	DNA-templated transcription, initiation
SPRI_3049	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SPRI_3050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SPRI_3051	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPRI_3052	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPRI_3056	COG4176	ABC-type proline glycine betaine transport system permease component
SPRI_3057	COG0517	IMP dehydrogenase activity
SPRI_3057	COG4175	Glycine betaine
SPRI_3065	COG0039	L-malate dehydrogenase activity
SPRI_3067	COG0538	isocitrate dehydrogenase activity
SPRI_3069	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPRI_3075	COG0138	bifunctional purine biosynthesis protein purh
SPRI_3081	COG0045	succinate-CoA ligase (ADP-forming) activity
SPRI_3084	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SPRI_3085	COG2425	protein containing a von Willebrand factor type A (vWA) domain
SPRI_3086	COG0714	Associated with various cellular activities
SPRI_3090	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SPRI_3096	COG0791	NLP P60 protein
SPRI_3098	COG2197	response regulator
SPRI_3104	COG0519	Catalyzes the synthesis of GMP from XMP
SPRI_3104	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SPRI_3108	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_3109	COG0515	serine threonine protein kinase
SPRI_3112	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPRI_3115	COG0516	GMP reductase activity
SPRI_3117	COG1595	DNA-templated transcription, initiation
SPRI_3118	COG2197	response regulator
SPRI_3120	COG0583	DNA-binding transcription factor activity
SPRI_3122	COG4221	oxidoreductase activity
SPRI_3124	COG0459	protein refolding
SPRI_3126	COG0726	polysaccharide deacetylase
SPRI_3136	COG4941	Belongs to the sigma-70 factor family
SPRI_3139	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SPRI_3144	COG0802	atpase or kinase
SPRI_3146	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SPRI_3149	COG0736	holo-[acyl-carrier-protein] synthase activity
SPRI_3150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPRI_3154	COG1072	(Pantothenic acid kinase))
SPRI_3156	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPRI_3157	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SPRI_3158	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPRI_3159	COG0488	(ABC) transporter
SPRI_3162	COG0101	tRNA pseudouridine synthase activity
SPRI_3163	COG0203	ribosomal protein L17
SPRI_3164	COG0202	RNA polymerase activity
SPRI_3165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPRI_3166	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SPRI_3167	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPRI_3168	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPRI_3170	COG0563	adenylate kinase activity
SPRI_3172	COG0200	Binds to the 23S rRNA
SPRI_3173	COG1841	ribosomal large subunit assembly
SPRI_3174	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPRI_3175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SPRI_3176	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SPRI_3177	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SPRI_3178	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SPRI_3179	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SPRI_3180	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SPRI_3181	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SPRI_3182	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPRI_3183	COG0255	Belongs to the universal ribosomal protein uL29 family
SPRI_3184	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SPRI_3185	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SPRI_3186	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SPRI_3187	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPRI_3188	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SPRI_3189	COG0089	rRNA binding
SPRI_3190	COG0088	Forms part of the polypeptide exit tunnel
SPRI_3191	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SPRI_3192	COG0051	transcription antitermination factor activity, RNA binding
SPRI_3196	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SPRI_3197	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SPRI_3199	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SPRI_3200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SPRI_3201	COG0085	RNA polymerase activity
SPRI_3202	COG0222	ribosome binding
SPRI_3203	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SPRI_3206	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SPRI_3208	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SPRI_3209	COG0436	Aminotransferase
SPRI_3210	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SPRI_3213	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SPRI_3214	COG0477	Major facilitator Superfamily
SPRI_3217	COG2030	dehydratase
SPRI_3218	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPRI_3219	COG0402	S-adenosylhomocysteine deaminase activity
SPRI_3224	COG1666	GTP binding
SPRI_3225	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPRI_3226	COG3145	DNA-N1-methyladenine dioxygenase activity
SPRI_3227	COG2261	transglycosylase associated protein
SPRI_3228	COG3304	Inner membrane component domain
SPRI_3229	COG0501	Belongs to the peptidase M48B family
SPRI_3230	COG1007	ATP synthesis coupled electron transport
SPRI_3233	COG0713	ATP synthesis coupled electron transport
SPRI_3234	COG0839	Belongs to the complex I subunit 6 family
SPRI_3235	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPRI_3236	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SPRI_3237	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPRI_3238	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPRI_3244	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SPRI_3244	COG0674	pyruvate-flavodoxin oxidoreductase activity
SPRI_3245	COG1013	pyruvate-flavodoxin oxidoreductase activity
SPRI_3246	COG1733	regulation of RNA biosynthetic process
SPRI_3247	COG0702	epimerase
SPRI_3253	COG4935	Belongs to the peptidase S8 family
SPRI_3253	COG2234	aminopeptidase activity
SPRI_3255	COG1131	(ABC) transporter
SPRI_3261	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPRI_3261	COG2207	Transcriptional regulator
SPRI_3262	COG1007	ATP synthesis coupled electron transport
SPRI_3264	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SPRI_3265	COG0713	ATP synthesis coupled electron transport
SPRI_3266	COG0839	Belongs to the complex I subunit 6 family
SPRI_3267	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPRI_3268	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SPRI_3269	COG1034	ATP synthesis coupled electron transport
SPRI_3270	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SPRI_3272	COG0649	NAD binding
SPRI_3273	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPRI_3274	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPRI_3281	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPRI_3286	COG2066	Belongs to the glutaminase family
SPRI_3287	COG2226	methyltransferase
SPRI_3289	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SPRI_3291	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SPRI_3296	COG1309	transcriptional regulator
SPRI_3299	COG1301	dicarboxylic acid transport
SPRI_3302	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SPRI_3305	COG0163	prenyltransferase activity
SPRI_3307	COG0109	protoheme IX farnesyltransferase activity
SPRI_3309	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SPRI_3311	COG0583	DNA-binding transcription factor activity
SPRI_3312	COG0697	spore germination
SPRI_3315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SPRI_3316	COG1333	cytochrome c biogenesis protein
SPRI_3318	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPRI_3320	COG0406	alpha-ribazole phosphatase activity
SPRI_3321	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SPRI_3331	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SPRI_3335	COG1690	Belongs to the RtcB family
SPRI_3340	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SPRI_3341	COG0018	arginyl-trna synthetase
SPRI_3345	COG2272	Belongs to the type-B carboxylesterase lipase family
SPRI_3351	COG0113	porphobilinogen synthase activity
SPRI_3352	COG2226	methyltransferase
SPRI_3353	COG1648	precorrin-2 dehydrogenase activity
SPRI_3353	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPRI_3354	COG0181	hydroxymethylbilane synthase activity
SPRI_3355	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SPRI_3356	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SPRI_3358	COG0560	Phosphoserine phosphatase
SPRI_3359	COG1595	DNA-templated transcription, initiation
SPRI_3366	COG0123	including yeast histone deacetylase and acetoin utilization protein
SPRI_3368	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPRI_3369	COG0180	Tryptophanyl-tRNA synthetase
SPRI_3370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPRI_3372	COG0842	Transport permease protein
SPRI_3372	COG1129	ABC transporter
SPRI_3374	COG4991	sh3 domain protein
SPRI_3376	COG0129	dihydroxy-acid dehydratase activity
SPRI_3378	COG1082	Xylose isomerase domain protein TIM barrel
SPRI_3379	COG0248	Ppx GppA phosphatase
SPRI_3383	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SPRI_3385	COG0671	phosphoesterase, PA-phosphatase related
SPRI_3386	COG1194	a g-specific adenine glycosylase
SPRI_3387	COG1595	DNA-templated transcription, initiation
SPRI_3389	COG0745	RESPONSE REGULATOR receiver
SPRI_3390	COG2205	protein histidine kinase activity
SPRI_3391	COG0739	heme binding
SPRI_3392	COG2027	D-alanyl-D-alanine carboxypeptidase
SPRI_3393	COG0542	response to heat
SPRI_3396	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SPRI_3400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SPRI_3402	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SPRI_3403	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SPRI_3407	COG0640	Transcriptional regulator
SPRI_3408	COG2197	response regulator
SPRI_3411	COG0649	NAD binding
SPRI_3413	COG1732	Glycine betaine
SPRI_3414	COG1174	glycine betaine transport
SPRI_3416	COG0517	IMP dehydrogenase activity
SPRI_3416	COG1125	glycine betaine transport
SPRI_3418	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SPRI_3418	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SPRI_3421	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPRI_3424	COG0667	Aldo Keto reductase
SPRI_3425	COG0302	gtp cyclohydrolase
SPRI_3428	COG0037	tRNA processing
SPRI_3431	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SPRI_3433	COG0586	Pfam SNARE associated Golgi protein
SPRI_3434	COG0393	Putative heavy-metal-binding
SPRI_3435	COG0789	Transcriptional regulator
SPRI_3436	COG0076	glutamate decarboxylase activity
SPRI_3440	COG2318	DinB family
SPRI_3441	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_3445	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPRI_3447	COG0254	rRNA binding
SPRI_3448	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPRI_3449	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPRI_3450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SPRI_3454	COG1136	(ABC) transporter
SPRI_3454	COG0577	efflux transmembrane transporter activity
SPRI_3455	COG0577	efflux transmembrane transporter activity
SPRI_3457	COG0110	maltose O-acetyltransferase activity
SPRI_3458	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPRI_3458	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPRI_3461	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPRI_3463	COG0583	DNA-binding transcription factor activity
SPRI_3466	COG2175	clavaminate synthase activity
SPRI_3467	COG0527	aspartate kinase activity
SPRI_3468	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPRI_3469	COG0697	spore germination
SPRI_3470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPRI_3471	COG4865	methylaspartate mutase activity
SPRI_3474	COG0439	Biotin carboxylase
SPRI_3475	COG0511	ligase activity, forming carbon-carbon bonds
SPRI_3476	COG0825	malonyl-CoA metabolic process
SPRI_3476	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPRI_3484	COG1960	acyl-CoA dehydrogenase activity
SPRI_3485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPRI_3485	COG2070	2-Nitropropane dioxygenase
SPRI_3487	COG0604	alcohol dehydrogenase
SPRI_3487	COG3321	synthase
SPRI_3492	COG0477	Major facilitator Superfamily
SPRI_3494	COG0475	glutathione-regulated potassium exporter activity
SPRI_3498	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SPRI_3507	COG0470	DNA polymerase III
SPRI_3508	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SPRI_3509	COG1754	DNA topoisomerase type I activity
SPRI_3509	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPRI_3511	COG2890	protein-(glutamine-N5) methyltransferase activity
SPRI_3513	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SPRI_3514	COG2172	sigma factor antagonist activity
SPRI_3515	COG1366	Belongs to the anti-sigma-factor antagonist family
SPRI_3516	COG1111	helicase
SPRI_3516	COG1205	dead DEAH box helicase
SPRI_3528	COG0659	secondary active sulfate transmembrane transporter activity
SPRI_3529	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPRI_3530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SPRI_3532	COG2267	carboxylic ester hydrolase activity
SPRI_3538	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPRI_3543	COG0003	Pfam Anion-transporting ATPase
SPRI_3545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPRI_3546	COG1610	YqeY-like protein
SPRI_3549	COG1408	metallophosphoesterase
SPRI_3560	COG1595	DNA-templated transcription, initiation
SPRI_3564	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SPRI_3565	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SPRI_3568	COG1802	Transcriptional regulator
SPRI_3571	COG0693	protein deglycase activity
SPRI_3577	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPRI_3580	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SPRI_3583	COG1131	(ABC) transporter
SPRI_3584	COG3559	Exporter of polyketide antibiotics
SPRI_3585	COG2124	cytochrome p450
SPRI_3586	COG2197	response regulator
SPRI_3587	COG4585	Histidine kinase
SPRI_3590	COG3844	kynureninase activity
SPRI_3594	COG0477	Major facilitator Superfamily
SPRI_3595	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPRI_3596	COG0191	fructose-bisphosphate aldolase activity
SPRI_3597	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPRI_3600	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPRI_3604	COG0542	response to heat
SPRI_3610	COG0789	Transcriptional regulator
SPRI_3611	COG0484	heat shock protein binding
SPRI_3612	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SPRI_3613	COG0443	Heat shock 70 kDa protein
SPRI_3614	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPRI_3615	COG2181	nitrate reductase activity
SPRI_3615	COG0247	lactate metabolic process
SPRI_3619	COG0717	Belongs to the dCTP deaminase family
SPRI_3622	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPRI_3635	COG2197	response regulator
SPRI_3639	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SPRI_3640	COG3958	Transketolase
SPRI_3641	COG3959	Transketolase, thiamine diphosphate binding domain
SPRI_3642	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPRI_3643	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SPRI_3646	COG0189	ligase activity
SPRI_3650	COG1115	amino acid carrier protein
SPRI_3659	COG3509	depolymerase
SPRI_3662	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPRI_3666	COG1902	pentaerythritol trinitrate reductase activity
SPRI_3666	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPRI_3677	COG1289	transmembrane transporter activity
SPRI_3682	COG2304	oxidoreductase activity
SPRI_3683	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPRI_3687	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SPRI_3690	COG1741	Belongs to the pirin family
SPRI_3692	COG1960	acyl-CoA dehydrogenase activity
SPRI_3693	COG1362	aminopeptidase activity
SPRI_3700	COG2271	Major facilitator Superfamily
SPRI_3702	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPRI_3703	COG0022	dehydrogenase e1 component
SPRI_3708	COG0515	serine threonine protein kinase
SPRI_3709	COG0515	serine threonine protein kinase
SPRI_3712	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPRI_3712	COG1136	(ABC) transporter
SPRI_3715	COG0604	alcohol dehydrogenase
SPRI_3716	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPRI_3722	COG1522	sequence-specific DNA binding
SPRI_3724	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPRI_3729	COG3396	Phenylacetate-CoA oxygenase
SPRI_3730	COG3460	Phenylacetate-CoA oxygenase
SPRI_3731	COG3396	Phenylacetate-CoA oxygenase
SPRI_3732	COG2151	metal-sulfur cluster biosynthetic enzyme
SPRI_3733	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPRI_3734	COG1960	acyl-CoA dehydrogenase activity
SPRI_3735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPRI_3738	COG1716	ATPase activity
SPRI_3739	COG1716	ATPase activity
SPRI_3742	COG0768	penicillin binding
SPRI_3743	COG0515	serine threonine protein kinase
SPRI_3744	COG3764	Sortase (surface protein transpeptidase)
SPRI_3745	COG3764	Sortase (surface protein transpeptidase)
SPRI_3748	COG3764	Sortase (surface protein transpeptidase)
SPRI_3751	COG0457	Tetratricopeptide repeat
SPRI_3751	COG0705	Rhomboid family
SPRI_3760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPRI_3761	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPRI_3762	COG1132	(ABC) transporter
SPRI_3764	COG4152	abc transporter atp-binding protein
SPRI_3773	COG0515	serine threonine protein kinase
SPRI_3778	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPRI_3780	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SPRI_3781	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SPRI_3782	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SPRI_3783	COG0592	DNA-directed DNA polymerase activity
SPRI_3784	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SPRI_3785	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SPRI_3786	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SPRI_3787	COG0706	membrane insertase activity
SPRI_3789	COG0357	Ribosomal RNA small subunit methyltransferase G
SPRI_3790	COG1192	Involved in chromosome partitioning
SPRI_3793	COG3118	belongs to the thioredoxin family
SPRI_3794	COG0492	ferredoxin-NADP+ reductase activity
SPRI_3796	COG1595	DNA-templated transcription, initiation
SPRI_3797	COG0515	serine threonine protein kinase
SPRI_3797	COG2815	serine threonine protein kinase
SPRI_3800	COG0617	tRNA 3'-terminal CCA addition
SPRI_3805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPRI_3810	COG0360	Binds together with S18 to 16S ribosomal RNA
SPRI_3811	COG0629	single-stranded DNA binding
SPRI_3812	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPRI_3813	COG0359	binds to the 23S rRNA
SPRI_3815	COG0305	Participates in initiation and elongation during chromosome replication
SPRI_3817	COG2814	Major facilitator Superfamily
SPRI_3824	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPRI_3832	COG0626	cystathionine gamma-synthase activity
SPRI_3833	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPRI_3834	COG1950	PFAM Membrane protein of
SPRI_3835	COG0662	Cupin 2, conserved barrel domain protein
SPRI_3840	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SPRI_3843	COG1609	Transcriptional regulator
SPRI_3844	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPRI_3845	COG1271	oxidase subunit
SPRI_3846	COG1294	oxidase, subunit
SPRI_3847	COG4988	ABC transporter
SPRI_3849	COG0739	heme binding
SPRI_3849	COG1196	nuclear chromosome segregation
SPRI_3849	COG0741	lytic transglycosylase activity
SPRI_3850	COG0561	phosphatase activity
SPRI_3852	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SPRI_3853	COG0789	Transcriptional regulator
SPRI_3855	COG1131	(ABC) transporter
SPRI_3860	COG0561	phosphatase activity
SPRI_3861	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SPRI_3863	COG2837	iron assimilation
SPRI_3864	COG2372	response to copper ion
SPRI_3866	COG1999	signal sequence binding
SPRI_3870	COG0006	proline dipeptidase activity
SPRI_3877	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPRI_3879	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SPRI_3885	COG1595	DNA-templated transcription, initiation
SPRI_3886	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_3887	COG0784	Response regulator, receiver
SPRI_3893	COG1404	Belongs to the peptidase S8 family
SPRI_3895	COG0745	RESPONSE REGULATOR receiver
SPRI_3896	COG2205	protein histidine kinase activity
SPRI_3898	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SPRI_3898	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SPRI_3899	COG0477	Major facilitator Superfamily
SPRI_3901	COG3467	pyridoxamine 5'-phosphate
SPRI_3902	COG2353	YceI-like domain
SPRI_3904	COG1846	Transcriptional regulator
SPRI_3907	COG1191	sigma factor activity
SPRI_3908	COG1191	sigma factor activity
SPRI_3914	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPRI_3919	COG4941	Belongs to the sigma-70 factor family
SPRI_3925	COG0151	Belongs to the GarS family
SPRI_3928	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SPRI_3930	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPRI_3931	COG0047	phosphoribosylformylglycinamidine synthase activity
SPRI_3932	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPRI_3934	COG0739	heme binding
SPRI_3938	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SPRI_3940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPRI_3944	COG1643	Atp-dependent helicase
SPRI_3946	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SPRI_3946	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SPRI_3947	COG0785	Cytochrome C biogenesis protein
SPRI_3950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPRI_3951	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPRI_3956	COG2226	methyltransferase
SPRI_3957	COG1959	2 iron, 2 sulfur cluster binding
SPRI_3958	COG1017	nitric oxide dioxygenase activity
SPRI_3958	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPRI_3960	COG1196	nuclear chromosome segregation
SPRI_3960	COG0739	heme binding
SPRI_3960	COG0741	lytic transglycosylase activity
SPRI_3961	COG0667	Aldo Keto reductase
SPRI_3963	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SPRI_3964	COG0579	oxidoreductase
SPRI_3969	COG1252	NADH dehydrogenase
SPRI_3972	COG1846	Transcriptional regulator
SPRI_3973	COG2197	response regulator
SPRI_3974	COG4585	Histidine kinase
SPRI_3976	COG1131	(ABC) transporter
SPRI_3986	COG0739	heme binding
SPRI_3986	COG0741	lytic transglycosylase activity
SPRI_3986	COG1196	nuclear chromosome segregation
SPRI_3987	COG0671	phosphoesterase, PA-phosphatase related
SPRI_3988	COG0277	FAD linked oxidase domain protein
SPRI_3991	COG1937	Protein conserved in bacteria
SPRI_3993	COG0306	phosphate transporter
SPRI_3995	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPRI_3998	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPRI_4001	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SPRI_4003	COG1131	(ABC) transporter
SPRI_4004	COG1725	Transcriptional regulator
SPRI_4005	COG0456	acetyltransferase
SPRI_4006	COG0737	Belongs to the 5'-nucleotidase family
SPRI_4008	COG0488	(ABC) transporter
SPRI_4011	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPRI_4012	COG1609	Transcriptional regulator
SPRI_4013	COG0745	RESPONSE REGULATOR receiver
SPRI_4018	COG2897	thiosulfate sulfurtransferase activity
SPRI_4026	COG3485	protocatechuate 3,4-dioxygenase
SPRI_4028	COG0354	folic acid binding
SPRI_4029	COG1490	D-aminoacyl-tRNA deacylase activity
SPRI_4036	COG2188	Transcriptional regulator
SPRI_4043	COG0667	Aldo Keto reductase
SPRI_4052	COG0438	transferase activity, transferring glycosyl groups
SPRI_4058	COG0588	phosphoglycerate mutase activity
SPRI_4060	COG4974	Belongs to the 'phage' integrase family
SPRI_4070	COG5002	protein histidine kinase activity
SPRI_4073	COG1329	Transcriptional regulator
SPRI_4074	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SPRI_4075	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SPRI_4076	COG0215	cysteine-tRNA ligase activity
SPRI_4079	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPRI_4081	COG3842	ATPase activity
SPRI_4083	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPRI_4090	COG2197	response regulator
SPRI_4091	COG4191	Histidine kinase
SPRI_4095	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SPRI_4099	COG1105	Belongs to the carbohydrate kinase PfkB family
SPRI_4100	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SPRI_4104	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPRI_4104	COG1877	trehalose-phosphatase activity
SPRI_4107	COG0463	Glycosyl transferase, family 2
SPRI_4120	COG1136	(ABC) transporter
SPRI_4124	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SPRI_4125	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SPRI_4131	COG3142	Participates in the control of copper homeostasis
SPRI_4132	COG3973	AAA domain
SPRI_4133	COG1131	(ABC) transporter
SPRI_4137	COG1061	Type III restriction enzyme res subunit
SPRI_4141	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SPRI_4142	COG1120	ATPase activity
SPRI_4143	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_4144	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_4147	COG1278	Cold shock
SPRI_4148	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SPRI_4149	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPRI_4151	COG2814	Major facilitator Superfamily
SPRI_4161	COG1136	(ABC) transporter
SPRI_4161	COG0577	efflux transmembrane transporter activity
SPRI_4162	COG4585	Histidine kinase
SPRI_4163	COG2197	response regulator
SPRI_4168	COG1366	Belongs to the anti-sigma-factor antagonist family
SPRI_4170	COG0596	Alpha beta hydrolase
SPRI_4174	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPRI_4176	COG2252	PERMEase
SPRI_4182	COG0667	Aldo Keto reductase
SPRI_4200	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SPRI_4202	COG0277	FAD linked oxidase domain protein
SPRI_4202	COG0247	lactate metabolic process
SPRI_4203	COG0259	pyridoxamine-phosphate oxidase activity
SPRI_4204	COG0583	DNA-binding transcription factor activity
SPRI_4205	COG5006	permease, DMT superfamily
SPRI_4210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPRI_4213	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_4214	COG1024	Enoyl-CoA hydratase
SPRI_4217	COG0259	pyridoxamine-phosphate oxidase activity
SPRI_4220	COG4821	SIS domain
SPRI_4222	COG0596	Alpha beta hydrolase
SPRI_4222	COG2945	thiolester hydrolase activity
SPRI_4233	COG1653	transport
SPRI_4244	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_4246	COG1960	acyl-CoA dehydrogenase activity
SPRI_4247	COG1960	acyl-CoA dehydrogenase activity
SPRI_4250	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_4251	COG1960	acyl-CoA dehydrogenase activity
SPRI_4252	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SPRI_4256	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SPRI_4257	COG1024	Enoyl-CoA hydratase
SPRI_4260	COG2072	flavoprotein involved in K transport
SPRI_4263	COG0259	pyridoxamine-phosphate oxidase activity
SPRI_4265	COG1960	acyl-CoA dehydrogenase activity
SPRI_4270	COG1309	transcriptional regulator
SPRI_4272	COG1024	Enoyl-CoA hydratase
SPRI_4275	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_4293	COG0531	amino acid
SPRI_4306	COG3209	COG3209 Rhs family protein
SPRI_4310	COG0789	Transcriptional regulator
SPRI_4317	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SPRI_4320	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_4325	COG1686	Belongs to the peptidase S11 family
SPRI_4330	COG0456	acetyltransferase
SPRI_4335	COG1309	transcriptional regulator
SPRI_4337	COG0582	viral genome integration into host DNA
SPRI_4338	COG0582	viral genome integration into host DNA
SPRI_4344	COG1846	Transcriptional regulator
SPRI_4345	COG3384	dioxygenase
SPRI_4346	COG1247	-acetyltransferase
SPRI_4349	COG0477	Major facilitator Superfamily
SPRI_4352	COG1970	mechanosensitive ion channel activity
SPRI_4354	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPRI_4359	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPRI_4360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPRI_4362	COG0315	cyclic pyranopterin monophosphate synthase activity
SPRI_4363	COG0521	Mo-molybdopterin cofactor biosynthetic process
SPRI_4364	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPRI_4373	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_4374	COG2267	carboxylic ester hydrolase activity
SPRI_4375	COG2072	flavoprotein involved in K transport
SPRI_4377	COG0793	Belongs to the peptidase S41A family
SPRI_4377	COG4946	Tricorn protease homolog
SPRI_4379	COG2409	Drug exporters of the RND superfamily
SPRI_4381	COG0310	cobalt ion transport
SPRI_4383	COG1122	ATPase activity
SPRI_4385	COG1764	response to oxidative stress
SPRI_4389	COG0442	prolyl-tRNA aminoacylation
SPRI_4395	COG0084	hydrolase, TatD family'
SPRI_4397	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SPRI_4398	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SPRI_4400	COG0488	(ABC) transporter
SPRI_4406	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPRI_4407	COG2197	response regulator
SPRI_4408	COG1846	Transcriptional regulator
SPRI_4409	COG4106	trans-aconitate 2-methyltransferase activity
SPRI_4413	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPRI_4417	COG0193	aminoacyl-tRNA hydrolase activity
SPRI_4418	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SPRI_4419	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPRI_4420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SPRI_4426	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPRI_4429	COG0477	Major facilitator Superfamily
SPRI_4430	COG1136	(ABC) transporter
SPRI_4431	COG1136	(ABC) transporter
SPRI_4431	COG0577	efflux transmembrane transporter activity
SPRI_4442	COG0463	Glycosyl transferase, family 2
SPRI_4444	COG0596	Alpha beta hydrolase
SPRI_4446	COG1215	transferase activity, transferring glycosyl groups
SPRI_4449	COG2124	cytochrome p450
SPRI_4452	COG0148	phosphopyruvate hydratase activity
SPRI_4457	COG1252	NADH dehydrogenase
SPRI_4458	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SPRI_4459	COG0577	efflux transmembrane transporter activity
SPRI_4459	COG1136	(ABC) transporter
SPRI_4460	COG1136	(ABC) transporter
SPRI_4465	COG0183	Belongs to the thiolase family
SPRI_4477	COG0019	diaminopimelate decarboxylase activity
SPRI_4478	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPRI_4481	COG1228	amidohydrolase
SPRI_4483	COG1794	racemase activity, acting on amino acids and derivatives
SPRI_4487	COG1191	sigma factor activity
SPRI_4496	COG0745	RESPONSE REGULATOR receiver
SPRI_4497	COG2205	protein histidine kinase activity
SPRI_4500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPRI_4506	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SPRI_4507	COG1960	acyl-CoA dehydrogenase activity
SPRI_4509	COG1316	TRANSCRIPTIONal
SPRI_4510	COG1607	acyl-coa hydrolase
SPRI_4511	COG1316	TRANSCRIPTIONal
SPRI_4514	COG1316	TRANSCRIPTIONal
SPRI_4520	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SPRI_4520	COG0778	Nitroreductase
SPRI_4528	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPRI_4529	COG2835	tetraacyldisaccharide 4'-kinase activity
SPRI_4531	COG1482	cell wall glycoprotein biosynthetic process
SPRI_4533	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SPRI_4538	COG0714	Associated with various cellular activities
SPRI_4542	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SPRI_4543	COG0745	RESPONSE REGULATOR receiver
SPRI_4544	COG5002	protein histidine kinase activity
SPRI_4544	COG5000	phosphorelay sensor kinase activity
SPRI_4545	COG0823	Involved in the tonB-independent uptake of proteins
SPRI_4547	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SPRI_4549	COG3214	Protein conserved in bacteria
SPRI_4551	COG0653	protein targeting
SPRI_4557	COG2902	Dehydrogenase
SPRI_4559	COG1388	LysM domain
SPRI_4559	COG1134	teichoic acid transport
SPRI_4561	COG1309	transcriptional regulator
SPRI_4565	COG0395	ABC-type sugar transport system, permease component
SPRI_4568	COG1674	ftsk spoiiie
SPRI_4569	COG0515	serine threonine protein kinase
SPRI_4570	COG0515	serine threonine protein kinase
SPRI_4571	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPRI_4574	COG2884	Cell division ATP-binding protein ftsE
SPRI_4576	COG0793	Belongs to the peptidase S41A family
SPRI_4576	COG3409	Peptidoglycan-binding domain 1 protein
SPRI_4577	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SPRI_4579	COG0583	DNA-binding transcription factor activity
SPRI_4581	COG0726	polysaccharide deacetylase
SPRI_4589	COG3973	AAA domain
SPRI_4591	COG0776	regulation of translation
SPRI_4593	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPRI_4594	COG1678	Uncharacterized ACR, COG1678
SPRI_4598	COG0395	ABC-type sugar transport system, permease component
SPRI_4599	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPRI_4605	COG1404	Belongs to the peptidase S8 family
SPRI_4623	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SPRI_4625	COG0277	FAD linked oxidase domain protein
SPRI_4630	COG3291	Pkd domain containing protein
SPRI_4630	COG4412	M6 family metalloprotease domain protein
SPRI_4632	COG1335	isochorismatase
SPRI_4634	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SPRI_4636	COG1113	amino acid transport
SPRI_4640	COG1234	tRNA 3'-trailer cleavage
SPRI_4641	COG1263	PTS System
SPRI_4641	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPRI_4641	COG2190	(PTS) system
SPRI_4642	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPRI_4642	COG1263	PTS System
SPRI_4643	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPRI_4643	COG1263	PTS System
SPRI_4644	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SPRI_4646	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPRI_4649	COG0477	Major facilitator Superfamily
SPRI_4652	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SPRI_4653	COG2076	Multidrug Resistance protein
SPRI_4654	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPRI_4657	COG4555	ABC transporter
SPRI_4660	COG2733	membrane
SPRI_4671	COG1074	ATP-dependent DNA helicase activity
SPRI_4684	COG3764	Sortase (surface protein transpeptidase)
SPRI_4685	COG4213	ABC transporter substrate-binding protein
SPRI_4688	COG1742	UPF0060 membrane protein
SPRI_4690	COG4702	Belongs to the UPF0303 family
SPRI_4691	COG0673	inositol 2-dehydrogenase activity
SPRI_4705	COG1126	abc transporter atp-binding protein
SPRI_4706	COG0765	amino acid transport
SPRI_4707	COG0765	amino acid transport
SPRI_4708	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPRI_4710	COG0154	amidase activity
SPRI_4714	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPRI_4716	COG1175	transmembrane transport
SPRI_4719	COG1349	DNA-binding transcription factor activity
SPRI_4721	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPRI_4739	COG0395	ABC-type sugar transport system, permease component
SPRI_4740	COG1175	transmembrane transport
SPRI_4743	COG0789	Transcriptional regulator
SPRI_4746	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPRI_4747	COG1595	DNA-templated transcription, initiation
SPRI_4749	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SPRI_4750	COG4977	sequence-specific DNA binding
SPRI_4752	COG0589	response to stress
SPRI_4754	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPRI_4759	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SPRI_4761	COG2375	cellular response to nickel ion
SPRI_4763	COG1960	acyl-CoA dehydrogenase activity
SPRI_4766	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPRI_4767	COG1309	transcriptional regulator
SPRI_4770	COG2197	response regulator
SPRI_4771	COG4585	Histidine kinase
SPRI_4772	COG1946	Acyl-CoA thioesterase
SPRI_4777	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPRI_4779	COG0028	Belongs to the TPP enzyme family
SPRI_4780	COG2197	response regulator
SPRI_4781	COG4585	Histidine kinase
SPRI_4782	COG1131	(ABC) transporter
SPRI_4791	COG1472	Belongs to the glycosyl hydrolase 3 family
SPRI_4797	COG0456	acetyltransferase
SPRI_4797	COG1846	Transcriptional regulator
SPRI_4800	COG1609	Transcriptional regulator
SPRI_4801	COG0673	inositol 2-dehydrogenase activity
SPRI_4811	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPRI_4817	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPRI_4819	COG3718	enzyme involved in inositol metabolism
SPRI_4820	COG3962	Belongs to the TPP enzyme family
SPRI_4825	COG1131	(ABC) transporter
SPRI_4837	COG0629	single-stranded DNA binding
SPRI_4842	COG1136	(ABC) transporter
SPRI_4842	COG0577	efflux transmembrane transporter activity
SPRI_4852	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPRI_4855	COG1486	melibiose metabolic process
SPRI_4856	COG0395	ABC-type sugar transport system, permease component
SPRI_4857	COG1175	transmembrane transport
SPRI_4860	COG0668	transmembrane transport
SPRI_4862	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPRI_4868	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPRI_4872	COG5002	protein histidine kinase activity
SPRI_4877	COG0494	nUDIX hydrolase
SPRI_4880	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SPRI_4881	COG1113	amino acid transport
SPRI_4882	COG1113	amino acid transport
SPRI_4884	COG1113	amino acid transport
SPRI_4887	COG4552	Acetyltransferase involved in intracellular survival and related
SPRI_4889	COG0475	glutathione-regulated potassium exporter activity
SPRI_4890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SPRI_4891	COG3594	Acyltransferase
SPRI_4898	COG0544	peptidyl-prolyl cis-trans isomerase activity
SPRI_4900	COG0740	serine-type endopeptidase activity
SPRI_4901	COG0740	serine-type endopeptidase activity
SPRI_4902	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SPRI_4904	COG0525	valine-tRNA ligase activity
SPRI_4905	COG0285	dihydrofolate synthase activity
SPRI_4907	COG0105	UTP biosynthetic process
SPRI_4908	COG1077	Cell shape determining protein MreB Mrl
SPRI_4911	COG0768	penicillin binding
SPRI_4912	COG0772	Belongs to the SEDS family
SPRI_4919	COG1530	ribonuclease E activity
SPRI_4920	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SPRI_4921	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPRI_4922	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SPRI_4923	COG0438	transferase activity, transferring glycosyl groups
SPRI_4924	COG0438	transferase activity, transferring glycosyl groups
SPRI_4926	COG0438	transferase activity, transferring glycosyl groups
SPRI_4929	COG1216	Glycosyl transferase, family 2
SPRI_4934	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SPRI_4936	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SPRI_4938	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SPRI_4941	COG0501	Belongs to the peptidase M48B family
SPRI_4943	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPRI_4945	COG0799	negative regulation of ribosome biogenesis
SPRI_4949	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SPRI_4951	COG0495	leucyl-tRNA aminoacylation
SPRI_4953	COG1307	EDD domain protein, DegV family
SPRI_4954	COG1555	photosystem II stabilization
SPRI_4954	COG1596	polysaccharide export
SPRI_4957	COG2162	N-hydroxyarylamine O-acetyltransferase activity
SPRI_4960	COG0268	Binds directly to 16S ribosomal RNA
SPRI_4961	COG0481	GTPase activity
SPRI_4967	COG1420	regulation of RNA biosynthetic process
SPRI_4968	COG0484	heat shock protein binding
SPRI_4973	COG4946	Tricorn protease homolog
SPRI_4973	COG0793	Belongs to the peptidase S41A family
SPRI_4974	COG0537	adenosine 5'-monophosphoramidase activity
SPRI_4975	COG1234	tRNA 3'-trailer cleavage
SPRI_4980	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SPRI_4982	COG2315	Protein conserved in bacteria
SPRI_4986	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SPRI_4989	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SPRI_4991	COG2409	Drug exporters of the RND superfamily
SPRI_4992	COG4585	Histidine kinase
SPRI_4993	COG2197	response regulator
SPRI_4997	COG1381	Involved in DNA repair and RecF pathway recombination
SPRI_4998	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPRI_5009	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPRI_5010	COG1121	(ABC) transporter
SPRI_5011	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPRI_5011	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPRI_5012	COG0423	glycine-tRNA ligase activity
SPRI_5017	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPRI_5017	COG0574	Belongs to the PEP-utilizing enzyme family
SPRI_5022	COG2146	nitrite reductase [NAD(P)H] activity
SPRI_5022	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SPRI_5023	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SPRI_5034	COG0243	molybdopterin cofactor binding
SPRI_5036	COG2949	membrane
SPRI_5039	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SPRI_5041	COG0358	DNA primase activity
SPRI_5044	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPRI_5047	COG1070	Carbohydrate kinase
SPRI_5053	COG1404	Belongs to the peptidase S8 family
SPRI_5054	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPRI_5054	COG0825	malonyl-CoA metabolic process
SPRI_5055	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_5057	COG1077	Cell shape determining protein MreB Mrl
SPRI_5061	COG2130	NADP-dependent
SPRI_5062	COG1764	response to oxidative stress
SPRI_5069	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_5070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_5071	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPRI_5074	COG1741	Belongs to the pirin family
SPRI_5076	COG2249	NAD(P)H dehydrogenase (quinone) activity
SPRI_5085	COG0745	RESPONSE REGULATOR receiver
SPRI_5086	COG2205	protein histidine kinase activity
SPRI_5090	COG0789	Transcriptional regulator
SPRI_5091	COG0667	Aldo Keto reductase
SPRI_5094	COG2197	response regulator
SPRI_5095	COG4585	Histidine kinase
SPRI_5098	COG1309	transcriptional regulator
SPRI_5099	COG0477	Major facilitator Superfamily
SPRI_5101	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPRI_5102	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SPRI_5111	COG1358	cellular component organization or biogenesis
SPRI_5113	COG0586	Pfam SNARE associated Golgi protein
SPRI_5114	COG4585	Histidine kinase
SPRI_5131	COG0500	methyltransferase
SPRI_5143	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SPRI_5152	COG0390	transport system, permease component
SPRI_5154	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPRI_5168	COG2124	cytochrome p450
SPRI_5169	COG0183	Belongs to the thiolase family
SPRI_5171	COG3845	ABC transporter
SPRI_5174	COG1657	PFAM Prenyltransferase squalene oxidase
SPRI_5180	COG1309	transcriptional regulator
SPRI_5181	COG0438	transferase activity, transferring glycosyl groups
SPRI_5185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPRI_5187	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPRI_5188	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SPRI_5197	COG0789	Transcriptional regulator
SPRI_5200	COG2197	response regulator
SPRI_5201	COG4585	Histidine kinase
SPRI_5204	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_5206	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPRI_5207	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPRI_5209	COG0406	alpha-ribazole phosphatase activity
SPRI_5209	COG0328	RNA-DNA hybrid ribonuclease activity
SPRI_5212	COG0800	Aldolase
SPRI_5213	COG3022	response to hydroperoxide
SPRI_5214	COG0557	exoribonuclease II activity
SPRI_5219	COG0515	serine threonine protein kinase
SPRI_5219	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SPRI_5220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPRI_5233	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_5234	COG3540	Alkaline phosphatase
SPRI_5236	COG2814	Major facilitator Superfamily
SPRI_5250	COG1994	Peptidase M50
SPRI_5258	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SPRI_5260	COG2814	Major facilitator Superfamily
SPRI_5261	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SPRI_5261	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPRI_5267	COG2409	Drug exporters of the RND superfamily
SPRI_5270	COG0174	glutamine synthetase
SPRI_5273	COG2226	methyltransferase
SPRI_5275	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SPRI_5277	COG1609	Transcriptional regulator
SPRI_5281	COG2365	Tyrosine phosphatase family
SPRI_5285	COG2197	response regulator
SPRI_5290	COG0745	RESPONSE REGULATOR receiver
SPRI_5298	COG0577	efflux transmembrane transporter activity
SPRI_5299	COG1136	(ABC) transporter
SPRI_5306	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SPRI_5307	COG0321	lipoyl(octanoyl) transferase activity
SPRI_5313	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_5316	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SPRI_5318	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPRI_5319	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPRI_5320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SPRI_5324	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SPRI_5326	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SPRI_5329	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPRI_5330	COG4106	trans-aconitate 2-methyltransferase activity
SPRI_5335	COG2197	response regulator
SPRI_5336	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPRI_5337	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SPRI_5343	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SPRI_5344	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SPRI_5348	COG1845	cytochrome c oxidase, subunit III
SPRI_5349	COG2010	Cytochrome c
SPRI_5350	COG0723	plastoquinol--plastocyanin reductase activity
SPRI_5351	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SPRI_5352	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SPRI_5353	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPRI_5354	COG1929	Belongs to the glycerate kinase type-1 family
SPRI_5356	COG0745	RESPONSE REGULATOR receiver
SPRI_5357	COG2205	protein histidine kinase activity
SPRI_5367	COG0438	transferase activity, transferring glycosyl groups
SPRI_5371	COG0003	Pfam Anion-transporting ATPase
SPRI_5373	COG1940	carbohydrate kinase activity
SPRI_5378	COG4585	Histidine kinase
SPRI_5379	COG2197	response regulator
SPRI_5380	COG0205	6-phosphofructokinase activity
SPRI_5381	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPRI_5384	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SPRI_5386	COG2193	ferroxidase activity
SPRI_5387	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SPRI_5389	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SPRI_5390	COG2815	serine threonine protein kinase
SPRI_5390	COG0515	serine threonine protein kinase
SPRI_5391	COG2022	thiamine diphosphate biosynthetic process
SPRI_5393	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPRI_5393	COG2022	thiamine diphosphate biosynthetic process
SPRI_5397	COG0352	thiamine-phosphate diphosphorylase activity
SPRI_5402	COG1309	transcriptional regulator
SPRI_5404	COG1121	(ABC) transporter
SPRI_5410	COG0714	Associated with various cellular activities
SPRI_5412	COG0275	rRNA processing
SPRI_5415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPRI_5417	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPRI_5418	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SPRI_5420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPRI_5421	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPRI_5424	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPRI_5425	COG1799	cell septum assembly
SPRI_5427	COG3599	regulation of cell shape
SPRI_5428	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SPRI_5429	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SPRI_5430	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPRI_5441	COG0587	DNA-directed DNA polymerase activity
SPRI_5443	COG1432	Conserved Protein
SPRI_5451	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SPRI_5452	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPRI_5453	COG0131	Imidazoleglycerol-phosphate dehydratase
SPRI_5455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SPRI_5456	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SPRI_5457	COG0251	oxidation-reduction process
SPRI_5458	COG0107	imidazoleglycerol-phosphate synthase activity
SPRI_5461	COG2508	Transcriptional regulator
SPRI_5462	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPRI_5464	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SPRI_5469	COG0134	indole-3-glycerol-phosphate synthase activity
SPRI_5471	COG0133	tryptophan synthase activity
SPRI_5472	COG0159	tryptophan synthase activity
SPRI_5474	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SPRI_5476	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPRI_5477	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPRI_5481	COG1397	ADP-ribosylglycohydrolase
SPRI_5483	COG0069	glutamate synthase activity
SPRI_5483	COG0070	glutamate synthase
SPRI_5483	COG0067	glutamate synthase
SPRI_5487	COG1960	acyl-CoA dehydrogenase activity
SPRI_5488	COG1960	acyl-CoA dehydrogenase activity
SPRI_5489	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_5490	COG1309	transcriptional regulator
SPRI_5491	COG0183	Belongs to the thiolase family
SPRI_5492	COG1278	Cold shock
SPRI_5494	COG4941	Belongs to the sigma-70 factor family
SPRI_5495	COG3795	YCII-related domain
SPRI_5499	COG1024	Enoyl-CoA hydratase
SPRI_5501	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_5503	COG2732	(Barnase) inhibitor
SPRI_5509	COG1605	Chorismate mutase
SPRI_5509	COG0287	Prephenate dehydrogenase
SPRI_5513	COG0737	Belongs to the 5'-nucleotidase family
SPRI_5518	COG0683	leucine binding
SPRI_5519	COG0559	Belongs to the binding-protein-dependent transport system permease family
SPRI_5521	COG0411	ABC transporter
SPRI_5523	COG3903	Transcriptional regulator
SPRI_5523	COG3629	intracellular signal transduction
SPRI_5524	COG0681	Belongs to the peptidase S26 family
SPRI_5529	COG1132	(ABC) transporter
SPRI_5530	COG2050	protein possibly involved in aromatic compounds catabolism
SPRI_5537	COG1643	Atp-dependent helicase
SPRI_5538	COG2226	methyltransferase
SPRI_5539	COG0539	negative regulation of cytoplasmic translation
SPRI_5542	COG0237	dephospho-CoA kinase activity
SPRI_5546	COG0330	HflC and HflK could
SPRI_5547	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPRI_5550	COG0402	S-adenosylhomocysteine deaminase activity
SPRI_5553	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPRI_5558	COG2313	pseudouridylate synthase activity
SPRI_5562	COG0477	Major facilitator Superfamily
SPRI_5563	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPRI_5564	COG0584	glycerophosphoryl diester phosphodiesterase
SPRI_5566	COG0556	nucleotide-excision repair
SPRI_5570	COG0861	Integral membrane protein TerC family
SPRI_5574	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPRI_5577	COG0322	excinuclease ABC activity
SPRI_5578	COG1660	Displays ATPase and GTPase activities
SPRI_5579	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPRI_5580	COG1481	regulation of sporulation
SPRI_5582	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SPRI_5583	COG0126	phosphoglycerate kinase activity
SPRI_5584	COG0149	triose-phosphate isomerase activity
SPRI_5585	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SPRI_5587	COG0166	Belongs to the GPI family
SPRI_5591	COG1846	Transcriptional regulator
SPRI_5592	COG2197	response regulator
SPRI_5593	COG4585	Histidine kinase
SPRI_5594	COG1131	(ABC) transporter
SPRI_5596	COG0363	glucosamine-6-phosphate deaminase activity
SPRI_5599	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPRI_5601	COG0109	protoheme IX farnesyltransferase activity
SPRI_5610	COG0719	Fe-S assembly protein
SPRI_5612	COG0396	ATPase activity
SPRI_5613	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPRI_5614	COG0822	iron-sulfur transferase activity
SPRI_5618	COG2171	N-acyltransferase activity
SPRI_5620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPRI_5628	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPRI_5629	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPRI_5633	COG0768	penicillin binding
SPRI_5634	COG2197	response regulator
SPRI_5635	COG4585	Histidine kinase
SPRI_5638	COG1414	Transcriptional regulator
SPRI_5646	COG1902	pentaerythritol trinitrate reductase activity
SPRI_5648	COG1917	Cupin 2, conserved barrel domain protein
SPRI_5651	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SPRI_5658	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPRI_5661	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SPRI_5662	COG0736	holo-[acyl-carrier-protein] synthase activity
SPRI_5664	COG1595	DNA-templated transcription, initiation
SPRI_5669	COG1797	cobyrinic acid a,c-diamide synthase activity
SPRI_5672	COG1492	cobalamin metabolic process
SPRI_5673	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SPRI_5676	COG0235	Class ii aldolase
SPRI_5680	COG0488	(ABC) transporter
SPRI_5690	COG3387	PFAM Glycoside hydrolase 15-related
SPRI_5693	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPRI_5697	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPRI_5700	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPRI_5701	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SPRI_5705	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SPRI_5709	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_5712	COG2186	Transcriptional regulator
SPRI_5713	COG2807	transmembrane transport
SPRI_5717	COG3830	Belongs to the UPF0237 family
SPRI_5717	COG0560	Phosphoserine phosphatase
SPRI_5718	COG1716	ATPase activity
SPRI_5718	COG0842	Transport permease protein
SPRI_5718	COG1131	(ABC) transporter
SPRI_5720	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SPRI_5721	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_5722	COG4585	Histidine kinase
SPRI_5723	COG2197	response regulator
SPRI_5726	COG1119	ATPase activity
SPRI_5731	COG1881	PFAM PEBP family protein
SPRI_5733	COG2094	Belongs to the DNA glycosylase MPG family
SPRI_5736	COG0647	UMP catabolic process
SPRI_5737	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_5738	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_5739	COG1120	ATPase activity
SPRI_5743	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SPRI_5744	COG0497	DNA recombination
SPRI_5747	COG3387	PFAM Glycoside hydrolase 15-related
SPRI_5748	COG0504	CTP synthase activity
SPRI_5749	COG0494	nUDIX hydrolase
SPRI_5752	COG0686	Belongs to the AlaDH PNT family
SPRI_5755	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SPRI_5756	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SPRI_5757	COG1187	pseudouridine synthase activity
SPRI_5766	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SPRI_5768	COG1160	GTP binding
SPRI_5776	COG0438	transferase activity, transferring glycosyl groups
SPRI_5781	COG0477	Major facilitator Superfamily
SPRI_5782	COG1960	acyl-CoA dehydrogenase activity
SPRI_5783	COG1799	cell septum assembly
SPRI_5790	COG0641	radical SAM
SPRI_5793	COG3629	intracellular signal transduction
SPRI_5793	COG3903	Transcriptional regulator
SPRI_5797	COG1309	transcriptional regulator
SPRI_5798	COG0477	Major facilitator Superfamily
SPRI_5799	COG0587	DNA-directed DNA polymerase activity
SPRI_5806	COG0789	Transcriptional regulator
SPRI_5808	COG4565	transcriptional regulatory protein
SPRI_5814	COG1725	Transcriptional regulator
SPRI_5817	COG2755	lipolytic protein G-D-S-L family
SPRI_5820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPRI_5827	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SPRI_5828	COG1309	transcriptional regulator
SPRI_5829	COG0243	molybdopterin cofactor binding
SPRI_5830	COG2851	Citrate transporter
SPRI_5834	COG3842	ATPase activity
SPRI_5837	COG0477	Major facilitator Superfamily
SPRI_5839	COG0640	Transcriptional regulator
SPRI_5841	COG1960	acyl-CoA dehydrogenase activity
SPRI_5844	COG0789	Transcriptional regulator
SPRI_5850	COG3876	Protein conserved in bacteria
SPRI_5851	COG0300	oxidoreductase activity
SPRI_5852	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_5854	COG1960	acyl-CoA dehydrogenase activity
SPRI_5859	COG2149	membrane
SPRI_5860	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SPRI_5865	COG3265	gluconokinase activity
SPRI_5866	COG2186	Transcriptional regulator
SPRI_5867	COG1113	amino acid transport
SPRI_5870	COG0564	pseudouridine synthase activity
SPRI_5874	COG0156	8-amino-7-oxononanoate synthase activity
SPRI_5881	COG0667	Aldo Keto reductase
SPRI_5882	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPRI_5885	COG0598	Magnesium transport protein CorA
SPRI_5889	COG0215	cysteine-tRNA ligase activity
SPRI_5892	COG4948	Mandelate Racemase Muconate Lactonizing
SPRI_5893	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_5894	COG2186	Transcriptional regulator
SPRI_5895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPRI_5896	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SPRI_5897	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPRI_5898	COG1414	Transcriptional regulator
SPRI_5899	COG0646	methionine synthase
SPRI_5899	COG1410	methionine synthase
SPRI_5901	COG0747	negative chemotaxis
SPRI_5902	COG2197	response regulator
SPRI_5904	COG0517	IMP dehydrogenase activity
SPRI_5904	COG1994	Peptidase M50
SPRI_5908	COG1222	aaa ATPase
SPRI_5909	COG4122	O-methyltransferase activity
SPRI_5911	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SPRI_5912	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SPRI_5913	COG1609	Transcriptional regulator
SPRI_5915	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SPRI_5916	COG0545	Peptidyl-prolyl cis-trans isomerase
SPRI_5918	COG2378	regulation of single-species biofilm formation
SPRI_5922	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SPRI_5923	COG0805	protein transport
SPRI_5932	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPRI_5933	COG4175	Glycine betaine
SPRI_5933	COG0517	IMP dehydrogenase activity
SPRI_5939	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPRI_5940	COG0531	amino acid
SPRI_5942	COG0174	glutamine synthetase
SPRI_5943	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_5944	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_5951	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SPRI_5952	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SPRI_5953	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SPRI_5954	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPRI_5955	COG5002	protein histidine kinase activity
SPRI_5956	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SPRI_5957	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPRI_5957	COG0072	phenylalanine-tRNA ligase activity
SPRI_5962	COG1649	PFAM Uncharacterised BCR, COG1649
SPRI_5964	COG0697	spore germination
SPRI_5972	COG0697	spore germination
SPRI_5974	COG4106	trans-aconitate 2-methyltransferase activity
SPRI_5976	COG0477	Major facilitator Superfamily
SPRI_5978	COG0697	spore germination
SPRI_5982	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SPRI_5983	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SPRI_5984	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SPRI_5985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SPRI_5986	COG1438	arginine binding
SPRI_5989	COG0137	argininosuccinate synthase activity
SPRI_5990	COG0165	Argininosuccinate lyase
SPRI_5991	COG3973	AAA domain
SPRI_5995	COG3629	intracellular signal transduction
SPRI_5995	COG3903	Transcriptional regulator
SPRI_5997	COG0477	Major facilitator Superfamily
SPRI_5998	COG0204	Acyl-transferase
SPRI_5998	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_5999	COG0584	glycerophosphoryl diester phosphodiesterase
SPRI_6006	COG2011	ABC-type metal ion transport system permease component
SPRI_6007	COG1464	Belongs to the NlpA lipoprotein family
SPRI_6010	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SPRI_6011	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPRI_6011	COG1648	precorrin-2 dehydrogenase activity
SPRI_6018	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPRI_6020	COG0456	acetyltransferase
SPRI_6029	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPRI_6032	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SPRI_6037	COG1560	Kdo2-lipid A biosynthetic process
SPRI_6038	COG0438	transferase activity, transferring glycosyl groups
SPRI_6040	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SPRI_6041	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SPRI_6042	COG0217	transcriptional regulatory protein
SPRI_6043	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SPRI_6044	COG0632	four-way junction helicase activity
SPRI_6045	COG2255	four-way junction helicase activity
SPRI_6047	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPRI_6048	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPRI_6049	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPRI_6050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SPRI_6051	COG2815	serine threonine protein kinase
SPRI_6051	COG0515	serine threonine protein kinase
SPRI_6054	COG1196	nuclear chromosome segregation
SPRI_6057	COG0124	histidyl-tRNA synthetase
SPRI_6061	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SPRI_6065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SPRI_6066	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SPRI_6068	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPRI_6070	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SPRI_6071	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPRI_6072	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SPRI_6073	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SPRI_6076	COG0006	proline dipeptidase activity
SPRI_6077	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SPRI_6078	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPRI_6080	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SPRI_6081	COG0540	Belongs to the ATCase OTCase family
SPRI_6082	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPRI_6084	COG0505	Belongs to the CarA family
SPRI_6085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SPRI_6086	COG0167	dihydroorotate dehydrogenase activity
SPRI_6087	COG0284	orotidine-5'-phosphate decarboxylase activity
SPRI_6092	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SPRI_6095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SPRI_6097	COG0604	alcohol dehydrogenase
SPRI_6099	COG2409	Drug exporters of the RND superfamily
SPRI_6100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SPRI_6101	COG2390	Transcriptional regulator
SPRI_6103	COG1191	sigma factor activity
SPRI_6105	COG0531	amino acid
SPRI_6107	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPRI_6110	COG2233	PERMEase
SPRI_6111	COG0738	Major facilitator superfamily
SPRI_6112	COG1846	Transcriptional regulator
SPRI_6112	COG1940	carbohydrate kinase activity
SPRI_6113	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPRI_6119	COG3201	nicotinamide mononucleotide transporter
SPRI_6120	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPRI_6120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPRI_6121	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SPRI_6122	COG0140	phosphoribosyl-ATP diphosphatase activity
SPRI_6123	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SPRI_6127	COG0464	growth
SPRI_6128	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SPRI_6131	COG1960	acyl-CoA dehydrogenase activity
SPRI_6135	COG1216	Glycosyl transferase, family 2
SPRI_6136	COG3030	protein affecting phage T7 exclusion by the F plasmid
SPRI_6138	COG2270	Major facilitator Superfamily
SPRI_6147	COG0438	transferase activity, transferring glycosyl groups
SPRI_6148	COG0438	transferase activity, transferring glycosyl groups
SPRI_6156	COG2018	Roadblock/LC7 domain
SPRI_6159	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SPRI_6160	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPRI_6161	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPRI_6164	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SPRI_6167	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPRI_6169	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPRI_6172	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SPRI_6176	COG1716	ATPase activity
SPRI_6180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPRI_6182	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SPRI_6182	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SPRI_6187	COG0384	phenazine biosynthesis protein PhzF
SPRI_6202	COG0484	heat shock protein binding
SPRI_6203	COG0443	Heat shock 70 kDa protein
SPRI_6204	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SPRI_6210	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SPRI_6212	COG2072	flavoprotein involved in K transport
SPRI_6213	COG0640	Transcriptional regulator
SPRI_6214	COG0640	Transcriptional regulator
SPRI_6222	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_6224	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SPRI_6226	COG2318	DinB family
SPRI_6230	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SPRI_6232	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SPRI_6233	COG2813	Specifically methylates the guanine in position
SPRI_6235	COG1968	undecaprenyl-diphosphatase activity
SPRI_6238	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SPRI_6245	COG2124	cytochrome p450
SPRI_6252	COG0110	maltose O-acetyltransferase activity
SPRI_6256	COG1832	CoA-binding protein
SPRI_6257	COG1739	Uncharacterized protein family UPF0029
SPRI_6258	COG0420	3'-5' exonuclease activity
SPRI_6259	COG0419	ATPase involved in DNA repair
SPRI_6260	COG1522	sequence-specific DNA binding
SPRI_6263	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_6266	COG0626	cystathionine gamma-synthase activity
SPRI_6271	COG1595	DNA-templated transcription, initiation
SPRI_6272	COG2188	Transcriptional regulator
SPRI_6273	COG1940	carbohydrate kinase activity
SPRI_6276	COG3397	chitin binding
SPRI_6278	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPRI_6289	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SPRI_6290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SPRI_6291	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SPRI_6294	COG0791	NLP P60 protein
SPRI_6296	COG0740	serine-type endopeptidase activity
SPRI_6299	COG1309	transcriptional regulator
SPRI_6300	COG0831	urea catabolic process
SPRI_6301	COG0832	Belongs to the urease beta subunit family
SPRI_6302	COG0804	urea catabolic process
SPRI_6303	COG0830	nickel cation binding
SPRI_6304	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SPRI_6305	COG0829	nickel cation binding
SPRI_6307	COG0204	Acyl-transferase
SPRI_6308	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPRI_6313	COG1957	nucleoside hydrolase
SPRI_6318	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPRI_6320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPRI_6324	COG3458	cephalosporin-C deacetylase activity
SPRI_6326	COG0747	negative chemotaxis
SPRI_6328	COG0444	Belongs to the ABC transporter superfamily
SPRI_6334	COG0205	6-phosphofructokinase activity
SPRI_6335	COG3442	glutamine amidotransferase
SPRI_6337	COG0242	peptide deformylase activity
SPRI_6339	COG1960	acyl-CoA dehydrogenase activity
SPRI_6342	COG0386	Belongs to the glutathione peroxidase family
SPRI_6343	COG1946	Acyl-CoA thioesterase
SPRI_6346	COG1132	(ABC) transporter
SPRI_6347	COG1132	(ABC) transporter
SPRI_6349	COG1132	(ABC) transporter
SPRI_6350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPRI_6351	COG2072	flavoprotein involved in K transport
SPRI_6355	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPRI_6360	COG0596	Alpha beta hydrolase
SPRI_6362	COG2835	tetraacyldisaccharide 4'-kinase activity
SPRI_6366	COG4981	capsule polysaccharide biosynthetic process
SPRI_6367	COG0500	methyltransferase
SPRI_6379	COG2706	6-phosphogluconolactonase activity
SPRI_6381	COG2971	BadF BadG BcrA BcrD
SPRI_6382	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SPRI_6386	COG1902	pentaerythritol trinitrate reductase activity
SPRI_6387	COG0640	Transcriptional regulator
SPRI_6391	COG1309	transcriptional regulator
SPRI_6393	COG0671	phosphoesterase, PA-phosphatase related
SPRI_6397	COG0584	glycerophosphoryl diester phosphodiesterase
SPRI_6403	COG0204	Acyl-transferase
SPRI_6407	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SPRI_6414	COG1175	transmembrane transport
SPRI_6418	COG1846	Transcriptional regulator
SPRI_6419	COG2409	Drug exporters of the RND superfamily
SPRI_6420	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_6427	COG1660	Displays ATPase and GTPase activities
SPRI_6429	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPRI_6430	COG0644	oxidoreductase
SPRI_6433	COG4585	Histidine kinase
SPRI_6434	COG2197	response regulator
SPRI_6438	COG2223	nitrite transmembrane transporter activity
SPRI_6439	COG1940	carbohydrate kinase activity
SPRI_6444	COG1136	(ABC) transporter
SPRI_6445	COG0577	efflux transmembrane transporter activity
SPRI_6451	COG1349	DNA-binding transcription factor activity
SPRI_6453	COG0464	growth
SPRI_6458	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SPRI_6463	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_6472	COG1764	response to oxidative stress
SPRI_6477	COG0488	(ABC) transporter
SPRI_6478	COG0488	(ABC) transporter
SPRI_6479	COG0302	gtp cyclohydrolase
SPRI_6487	COG1609	Transcriptional regulator
SPRI_6491	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPRI_6492	COG1129	ABC transporter
SPRI_6494	COG3347	Dehydrogenase
SPRI_6494	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_6495	COG1070	Carbohydrate kinase
SPRI_6498	COG0247	lactate metabolic process
SPRI_6499	COG1139	Iron-sulfur cluster binding protein
SPRI_6500	COG1556	Lactate utilization protein
SPRI_6502	COG0187	DNA topoisomerase II activity
SPRI_6506	COG1621	beta-fructofuranosidase activity
SPRI_6511	COG1609	Transcriptional regulator
SPRI_6515	COG2318	DinB family
SPRI_6516	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_6518	COG0640	Transcriptional regulator
SPRI_6521	COG1595	DNA-templated transcription, initiation
SPRI_6527	COG0640	Transcriptional regulator
SPRI_6528	COG0798	PFAM Bile acid sodium symporter
SPRI_6529	COG2072	flavoprotein involved in K transport
SPRI_6531	COG0667	Aldo Keto reductase
SPRI_6536	COG1063	alcohol dehydrogenase
SPRI_6538	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPRI_6539	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SPRI_6539	COG1672	PFAM Archaeal ATPase
SPRI_6540	COG0456	acetyltransferase
SPRI_6541	COG0435	Glutathione S-transferase
SPRI_6546	COG1454	alcohol dehydrogenase
SPRI_6556	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SPRI_6558	COG0346	lactoylglutathione lyase activity
SPRI_6560	COG2814	Major facilitator Superfamily
SPRI_6562	COG1846	Transcriptional regulator
SPRI_6575	COG1175	transmembrane transport
SPRI_6576	COG0395	ABC-type sugar transport system, permease component
SPRI_6580	COG0673	inositol 2-dehydrogenase activity
SPRI_6583	COG4214	carbohydrate transport
SPRI_6584	COG1129	ABC transporter
SPRI_6585	COG4213	ABC transporter substrate-binding protein
SPRI_6587	COG1414	Transcriptional regulator
SPRI_6588	COG3386	PFAM SMP-30 Gluconolaconase
SPRI_6592	COG1175	transmembrane transport
SPRI_6593	COG0395	ABC-type sugar transport system, permease component
SPRI_6594	COG3507	Belongs to the glycosyl hydrolase 43 family
SPRI_6599	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPRI_6601	COG1686	Belongs to the peptidase S11 family
SPRI_6603	COG0659	secondary active sulfate transmembrane transporter activity
SPRI_6610	COG2197	response regulator
SPRI_6612	COG2838	Isocitrate dehydrogenase
SPRI_6614	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPRI_6617	COG2205	protein histidine kinase activity
SPRI_6625	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SPRI_6625	COG5297	Belongs to the glycosyl hydrolase family 6
SPRI_6628	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SPRI_6629	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SPRI_6630	COG0655	NAD(P)H dehydrogenase (quinone) activity
SPRI_6631	COG0028	Belongs to the TPP enzyme family
SPRI_6632	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SPRI_6636	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_6643	COG1609	Transcriptional regulator
SPRI_6645	COG1175	transmembrane transport
SPRI_6660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SPRI_6661	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SPRI_6662	COG2080	2 iron, 2 sulfur cluster binding
SPRI_6663	COG0723	plastoquinol--plastocyanin reductase activity
SPRI_6663	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPRI_6669	COG2197	response regulator
SPRI_6670	COG4585	Histidine kinase
SPRI_6671	COG0667	Aldo Keto reductase
SPRI_6674	COG1175	transmembrane transport
SPRI_6675	COG0395	ABC-type sugar transport system, permease component
SPRI_6688	COG0842	Transport permease protein
SPRI_6688	COG1131	(ABC) transporter
SPRI_6688	COG1716	ATPase activity
SPRI_6692	COG0477	Major facilitator Superfamily
SPRI_6693	COG3387	PFAM Glycoside hydrolase 15-related
SPRI_6698	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPRI_6702	COG2197	response regulator
SPRI_6704	COG0477	Major facilitator Superfamily
SPRI_6723	COG1222	aaa ATPase
SPRI_6731	COG0363	glucosamine-6-phosphate deaminase activity
SPRI_6733	COG1595	DNA-templated transcription, initiation
SPRI_6744	COG1653	transport
SPRI_6745	COG4209	transmembrane transport
SPRI_6746	COG0395	ABC-type sugar transport system, permease component
SPRI_6754	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_6755	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_6758	COG2045	Belongs to the ComB family
SPRI_6762	COG1733	regulation of RNA biosynthetic process
SPRI_6764	COG2318	DinB family
SPRI_6774	COG2124	cytochrome p450
SPRI_6784	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SPRI_6784	COG2010	Cytochrome c
SPRI_6790	COG1295	ribonuclease BN
SPRI_6796	COG0640	Transcriptional regulator
SPRI_6799	COG4552	Acetyltransferase involved in intracellular survival and related
SPRI_6800	COG2936	dipeptidyl-peptidase activity
SPRI_6808	COG2132	Multicopper oxidase
SPRI_6812	COG1122	ATPase activity
SPRI_6814	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
SPRI_6815	COG0310	cobalt ion transport
SPRI_6816	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPRI_6817	COG1461	Dihydroxyacetone kinase
SPRI_6818	COG2376	Dihydroxyacetone kinase
SPRI_6829	COG0739	heme binding
SPRI_6829	COG0741	lytic transglycosylase activity
SPRI_6829	COG1196	nuclear chromosome segregation
SPRI_6839	COG0747	negative chemotaxis
SPRI_6843	COG0783	Belongs to the Dps family
SPRI_6844	COG0009	L-threonylcarbamoyladenylate synthase
SPRI_6848	COG2084	Dehydrogenase
SPRI_6855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SPRI_6856	COG0243	molybdopterin cofactor binding
SPRI_6858	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_6859	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPRI_6861	COG0726	polysaccharide deacetylase
SPRI_6862	COG1349	DNA-binding transcription factor activity
SPRI_6863	COG1105	Belongs to the carbohydrate kinase PfkB family
SPRI_6865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPRI_6866	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPRI_6869	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPRI_6880	COG2890	protein-(glutamine-N5) methyltransferase activity
SPRI_6884	COG2124	cytochrome p450
SPRI_6893	COG1191	sigma factor activity
SPRI_6904	COG0693	protein deglycase activity
SPRI_6905	COG0517	IMP dehydrogenase activity
SPRI_6911	COG3958	Transketolase
SPRI_6917	COG1024	Enoyl-CoA hydratase
SPRI_6919	COG1960	acyl-CoA dehydrogenase activity
SPRI_6924	COG3548	integral membrane protein
SPRI_6927	COG0730	response to heat
SPRI_6928	COG1937	Protein conserved in bacteria
SPRI_6929	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPRI_6930	COG0515	serine threonine protein kinase
SPRI_6932	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPRI_6934	COG0667	Aldo Keto reductase
SPRI_6935	COG2815	serine threonine protein kinase
SPRI_6935	COG0515	serine threonine protein kinase
SPRI_6936	COG2070	2-Nitropropane dioxygenase
SPRI_6938	COG2226	methyltransferase
SPRI_6944	COG0387	Pfam Sodium calcium exchanger
SPRI_6949	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_6956	COG0483	inositol monophosphate 1-phosphatase activity
SPRI_6958	COG1024	Enoyl-CoA hydratase
SPRI_6971	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPRI_6977	COG3290	protein histidine kinase activity
SPRI_6982	COG1573	uracil-dna glycosylase
SPRI_7003	COG1309	transcriptional regulator
SPRI_7010	COG1191	sigma factor activity
SPRI_7014	COG2205	protein histidine kinase activity
SPRI_7014	COG0784	Response regulator, receiver
SPRI_7014	COG5002	protein histidine kinase activity
SPRI_7015	COG5002	protein histidine kinase activity
SPRI_7015	COG3447	MASE1 domain protein
SPRI_7015	COG5001	Diguanylate cyclase
SPRI_7039	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPRI_7041	COG0477	Major facilitator Superfamily
SPRI_7043	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPRI_7044	COG1021	2,3-dihydroxybenzoate-AMP ligase
SPRI_7045	COG2423	ornithine cyclodeaminase activity
SPRI_7046	COG2124	cytochrome p450
SPRI_7047	COG0512	Glutamine amidotransferase of anthranilate synthase
SPRI_7047	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPRI_7048	COG0287	Prephenate dehydrogenase
SPRI_7049	COG1605	Chorismate mutase
SPRI_7050	COG2890	protein-(glutamine-N5) methyltransferase activity
SPRI_7052	COG0022	dehydrogenase e1 component
SPRI_7053	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_7053	COG0300	oxidoreductase activity
SPRI_7053	COG3321	synthase
SPRI_7053	COG4221	oxidoreductase activity
SPRI_7054	COG4221	oxidoreductase activity
SPRI_7054	COG3321	synthase
SPRI_7054	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_7054	COG0300	oxidoreductase activity
SPRI_7055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_7056	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_7057	COG3425	synthase
SPRI_7059	COG1024	Enoyl-CoA hydratase
SPRI_7060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPRI_7060	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_7060	COG3321	synthase
SPRI_7060	COG4221	oxidoreductase activity
SPRI_7066	COG3629	intracellular signal transduction
SPRI_7075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_7082	COG1960	acyl-CoA dehydrogenase activity
SPRI_7086	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_7089	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPRI_7091	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPRI_7106	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_7107	COG3425	synthase
SPRI_7109	COG1024	Enoyl-CoA hydratase
SPRI_7113	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SPRI_7118	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPRI_7123	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPRI_7125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SPRI_7126	COG0159	tryptophan synthase activity
SPRI_7127	COG0662	Cupin 2, conserved barrel domain protein
SPRI_7128	COG1960	acyl-CoA dehydrogenase activity
SPRI_7130	COG0135	phosphoribosylanthranilate isomerase activity
SPRI_7133	COG1063	alcohol dehydrogenase
SPRI_7135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPRI_7138	COG2706	6-phosphogluconolactonase activity
SPRI_7141	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPRI_7142	COG3265	gluconokinase activity
SPRI_7150	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_7158	COG2197	response regulator
SPRI_7159	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPRI_7161	COG1024	Enoyl-CoA hydratase
SPRI_7165	COG3251	PFAM MbtH domain protein
SPRI_7171	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SPRI_7173	COG0646	methionine synthase
SPRI_7173	COG1410	methionine synthase
SPRI_7184	COG0596	Alpha beta hydrolase
SPRI_7187	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPRI_7190	COG2072	flavoprotein involved in K transport
SPRI_7193	COG0156	8-amino-7-oxononanoate synthase activity
SPRI_7194	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_7196	COG2030	dehydratase
SPRI_7199	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SPRI_7200	COG0662	Cupin 2, conserved barrel domain protein
SPRI_7201	COG1960	acyl-CoA dehydrogenase activity
SPRI_7203	COG0134	indole-3-glycerol-phosphate synthase activity
SPRI_7208	COG2132	Multicopper oxidase
SPRI_7211	COG0110	maltose O-acetyltransferase activity
SPRI_7223	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SPRI_7228	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPRI_7231	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SPRI_7235	COG0513	Belongs to the DEAD box helicase family
SPRI_7238	COG2223	nitrite transmembrane transporter activity
SPRI_7239	COG2207	Transcriptional regulator
SPRI_7240	COG3795	YCII-related domain
SPRI_7241	COG4941	Belongs to the sigma-70 factor family
SPRI_7256	COG1309	transcriptional regulator
SPRI_7259	COG1695	Transcriptional regulator
SPRI_7262	COG0789	Transcriptional regulator
SPRI_7269	COG1278	Cold shock
SPRI_7276	COG0395	ABC-type sugar transport system, permease component
SPRI_7281	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SPRI_7286	COG2318	DinB family
SPRI_7298	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SPRI_7299	COG0305	Participates in initiation and elongation during chromosome replication
SPRI_7315	COG0420	3'-5' exonuclease activity
SPRI_7316	COG0419	ATPase involved in DNA repair
SPRI_7335	COG0419	ATPase involved in DNA repair
SPRI_7336	COG0420	3'-5' exonuclease activity
SPRI_7348	COG0305	Participates in initiation and elongation during chromosome replication