locus-tag	class	description
HZZ00_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HZZ00_00010	COG0592	DNA-directed DNA polymerase activity
HZZ00_00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HZZ00_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZZ00_00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HZZ00_00030	COG0187	DNA topoisomerase II activity
HZZ00_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZZ00_00065	COG2319	Wd-40 repeat
HZZ00_00065	COG4249	Peptidase C14 caspase catalytic subunit p20
HZZ00_00095	COG0515	serine threonine protein kinase
HZZ00_00135	COG0705	Rhomboid family
HZZ00_00160	COG3764	Sortase (surface protein transpeptidase)
HZZ00_00165	COG3764	Sortase (surface protein transpeptidase)
HZZ00_00170	COG0515	serine threonine protein kinase
HZZ00_00190	COG1716	ATPase activity
HZZ00_00195	COG1716	ATPase activity
HZZ00_00205	COG0477	Major facilitator Superfamily
HZZ00_00230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZZ00_00235	COG2151	metal-sulfur cluster biosynthetic enzyme
HZZ00_00240	COG3396	Phenylacetate-CoA oxygenase
HZZ00_00245	COG3460	Phenylacetate-CoA oxygenase
HZZ00_00250	COG3396	Phenylacetate-CoA oxygenase
HZZ00_00275	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZZ00_00280	COG1309	transcriptional regulator
HZZ00_00285	COG1522	sequence-specific DNA binding
HZZ00_00315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZZ00_00320	COG3321	synthase
HZZ00_00320	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_00320	COG0604	alcohol dehydrogenase
HZZ00_00335	COG0515	serine threonine protein kinase
HZZ00_00340	COG0515	serine threonine protein kinase
HZZ00_00355	COG0022	dehydrogenase e1 component
HZZ00_00360	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZZ00_00430	COG2271	Major facilitator Superfamily
HZZ00_00465	COG1362	aminopeptidase activity
HZZ00_00470	COG1960	acyl-CoA dehydrogenase activity
HZZ00_00480	COG1741	Belongs to the pirin family
HZZ00_00495	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HZZ00_00505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZZ00_00515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZZ00_00520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZZ00_00545	COG1473	amidohydrolase
HZZ00_00565	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZZ00_00570	COG1957	nucleoside hydrolase
HZZ00_00575	COG0366	Alpha amylase catalytic
HZZ00_00590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HZZ00_00640	COG0701	Predicted permease
HZZ00_00665	COG2188	Transcriptional regulator
HZZ00_00675	COG1595	DNA-templated transcription, initiation
HZZ00_00680	COG1252	NADH dehydrogenase
HZZ00_00700	COG0640	Transcriptional regulator
HZZ00_00705	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZZ00_00725	COG1902	pentaerythritol trinitrate reductase activity
HZZ00_00735	COG0714	Associated with various cellular activities
HZZ00_00750	COG1278	Cold shock
HZZ00_00770	COG0513	Belongs to the DEAD box helicase family
HZZ00_00775	COG1278	Cold shock
HZZ00_00800	COG0038	chloride channel
HZZ00_00805	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZZ00_00805	COG0515	serine threonine protein kinase
HZZ00_00815	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_00820	COG1309	transcriptional regulator
HZZ00_00830	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_00840	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
HZZ00_00855	COG0717	Belongs to the dCTP deaminase family
HZZ00_00860	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HZZ00_00880	COG0247	lactate metabolic process
HZZ00_00880	COG2181	nitrate reductase activity
HZZ00_00885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZZ00_00890	COG0443	Heat shock 70 kDa protein
HZZ00_00895	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HZZ00_00900	COG0484	heat shock protein binding
HZZ00_00905	COG0789	Transcriptional regulator
HZZ00_00910	COG4213	ABC transporter substrate-binding protein
HZZ00_00945	COG0542	response to heat
HZZ00_00970	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HZZ00_00985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HZZ00_00995	COG0477	Major facilitator Superfamily
HZZ00_01010	COG3844	kynureninase activity
HZZ00_01030	COG4585	Histidine kinase
HZZ00_01035	COG2197	response regulator
HZZ00_01040	COG4585	Histidine kinase
HZZ00_01045	COG2197	response regulator
HZZ00_01060	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HZZ00_01065	COG0737	Belongs to the 5'-nucleotidase family
HZZ00_01075	COG1802	Transcriptional regulator
HZZ00_01085	COG0515	serine threonine protein kinase
HZZ00_01085	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZZ00_01100	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HZZ00_01105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HZZ00_01125	COG1595	DNA-templated transcription, initiation
HZZ00_01150	COG3883	PFAM NLP P60 protein
HZZ00_01150	COG0791	NLP P60 protein
HZZ00_01160	COG0438	transferase activity, transferring glycosyl groups
HZZ00_01190	COG0588	phosphoglycerate mutase activity
HZZ00_01200	COG2188	Transcriptional regulator
HZZ00_01235	COG5002	protein histidine kinase activity
HZZ00_01250	COG1329	Transcriptional regulator
HZZ00_01255	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HZZ00_01260	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HZZ00_01270	COG0215	cysteine-tRNA ligase activity
HZZ00_01285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HZZ00_01295	COG3842	ATPase activity
HZZ00_01315	COG0667	Aldo Keto reductase
HZZ00_01335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZZ00_01340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZZ00_01350	COG0583	DNA-binding transcription factor activity
HZZ00_01355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZZ00_01365	COG0662	Cupin 2, conserved barrel domain protein
HZZ00_01375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZZ00_01380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZZ00_01385	COG2867	negative regulation of translational initiation
HZZ00_01410	COG0723	plastoquinol--plastocyanin reductase activity
HZZ00_01410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZZ00_01450	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HZZ00_01470	COG3300	MHYT domain
HZZ00_01470	COG5001	Diguanylate cyclase
HZZ00_01515	COG0463	Glycosyl transferase, family 2
HZZ00_01530	COG1278	Cold shock
HZZ00_01535	COG0459	protein refolding
HZZ00_01550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZZ00_01555	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HZZ00_01560	COG1737	Transcriptional regulator
HZZ00_01595	COG2268	Band 7 protein
HZZ00_01605	COG3973	AAA domain
HZZ00_01645	COG1278	Cold shock
HZZ00_01650	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HZZ00_01655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HZZ00_01665	COG2814	Major facilitator Superfamily
HZZ00_01695	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZZ00_01705	COG2252	PERMEase
HZZ00_01735	COG0667	Aldo Keto reductase
HZZ00_01750	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HZZ00_01755	COG0247	lactate metabolic process
HZZ00_01755	COG0277	FAD linked oxidase domain protein
HZZ00_01765	COG5006	permease, DMT superfamily
HZZ00_01785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZZ00_01805	COG1309	transcriptional regulator
HZZ00_01820	COG0259	pyridoxamine-phosphate oxidase activity
HZZ00_01835	COG4821	SIS domain
HZZ00_01845	COG2945	thiolester hydrolase activity
HZZ00_01845	COG0596	Alpha beta hydrolase
HZZ00_01925	COG2072	flavoprotein involved in K transport
HZZ00_01935	COG0259	pyridoxamine-phosphate oxidase activity
HZZ00_01940	COG1280	lysine exporter protein (LysE YggA)
HZZ00_01945	COG1522	sequence-specific DNA binding
HZZ00_01960	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZZ00_01960	COG0515	serine threonine protein kinase
HZZ00_01970	COG3629	intracellular signal transduction
HZZ00_01970	COG3903	Transcriptional regulator
HZZ00_02010	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HZZ00_02045	COG3903	Transcriptional regulator
HZZ00_02045	COG3629	intracellular signal transduction
HZZ00_02070	COG1686	Belongs to the peptidase S11 family
HZZ00_02095	COG0386	Belongs to the glutathione peroxidase family
HZZ00_02120	COG0326	Molecular chaperone. Has ATPase activity
HZZ00_02135	COG0589	response to stress
HZZ00_02170	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZZ00_02210	COG0477	Major facilitator Superfamily
HZZ00_02230	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZZ00_02265	COG0366	Alpha amylase catalytic
HZZ00_02270	COG0366	Alpha amylase catalytic
HZZ00_02290	COG1309	transcriptional regulator
HZZ00_02310	COG1846	Transcriptional regulator
HZZ00_02315	COG3384	dioxygenase
HZZ00_02320	COG1247	-acetyltransferase
HZZ00_02350	COG1376	ErfK ybiS ycfS ynhG family protein
HZZ00_02370	COG1970	mechanosensitive ion channel activity
HZZ00_02380	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HZZ00_02400	COG2366	antibiotic biosynthetic process
HZZ00_02405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HZZ00_02410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HZZ00_02420	COG0315	cyclic pyranopterin monophosphate synthase activity
HZZ00_02425	COG0315	cyclic pyranopterin monophosphate synthase activity
HZZ00_02425	COG0521	Mo-molybdopterin cofactor biosynthetic process
HZZ00_02430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZZ00_02445	COG0454	-acetyltransferase
HZZ00_02460	COG2072	flavoprotein involved in K transport
HZZ00_02470	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_02480	COG0793	Belongs to the peptidase S41A family
HZZ00_02480	COG4946	Tricorn protease homolog
HZZ00_02490	COG2409	Drug exporters of the RND superfamily
HZZ00_02495	COG0442	prolyl-tRNA aminoacylation
HZZ00_02515	COG1122	ATPase activity
HZZ00_02525	COG0310	cobalt ion transport
HZZ00_02575	COG0084	hydrolase, TatD family'
HZZ00_02585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HZZ00_02590	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HZZ00_02595	COG0488	(ABC) transporter
HZZ00_02635	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HZZ00_02645	COG2197	response regulator
HZZ00_02655	COG4106	trans-aconitate 2-methyltransferase activity
HZZ00_02665	COG1309	transcriptional regulator
HZZ00_02675	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HZZ00_02685	COG0193	aminoacyl-tRNA hydrolase activity
HZZ00_02690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HZZ00_02695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HZZ00_02700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HZZ00_02710	COG4585	Histidine kinase
HZZ00_02740	COG1136	(ABC) transporter
HZZ00_02745	COG0577	efflux transmembrane transporter activity
HZZ00_02745	COG1136	(ABC) transporter
HZZ00_02805	COG2124	cytochrome p450
HZZ00_02820	COG0148	phosphopyruvate hydratase activity
HZZ00_02840	COG1252	NADH dehydrogenase
HZZ00_02845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZZ00_02850	COG0577	efflux transmembrane transporter activity
HZZ00_02855	COG1136	(ABC) transporter
HZZ00_02855	COG0577	efflux transmembrane transporter activity
HZZ00_02885	COG0183	Belongs to the thiolase family
HZZ00_02890	COG2755	lipolytic protein G-D-S-L family
HZZ00_02955	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HZZ00_02970	COG1228	amidohydrolase
HZZ00_02975	COG1191	sigma factor activity
HZZ00_02980	COG1366	Belongs to the anti-sigma-factor antagonist family
HZZ00_02990	COG3104	oligopeptide transport
HZZ00_02995	COG0745	RESPONSE REGULATOR receiver
HZZ00_03000	COG2205	protein histidine kinase activity
HZZ00_03040	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HZZ00_03055	COG2801	Transposase and inactivated derivatives
HZZ00_03055	COG3415	Transposase
HZZ00_03060	COG1316	TRANSCRIPTIONal
HZZ00_03065	COG1607	acyl-coa hydrolase
HZZ00_03070	COG1316	TRANSCRIPTIONal
HZZ00_03080	COG1316	TRANSCRIPTIONal
HZZ00_03085	COG1316	TRANSCRIPTIONal
HZZ00_03110	COG0778	Nitroreductase
HZZ00_03110	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HZZ00_03115	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HZZ00_03155	COG2835	tetraacyldisaccharide 4'-kinase activity
HZZ00_03165	COG1482	cell wall glycoprotein biosynthetic process
HZZ00_03175	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HZZ00_03215	COG0714	Associated with various cellular activities
HZZ00_03235	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HZZ00_03240	COG0745	RESPONSE REGULATOR receiver
HZZ00_03245	COG5002	protein histidine kinase activity
HZZ00_03245	COG5000	phosphorelay sensor kinase activity
HZZ00_03250	COG0823	Involved in the tonB-independent uptake of proteins
HZZ00_03260	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HZZ00_03265	COG2197	response regulator
HZZ00_03270	COG3214	Protein conserved in bacteria
HZZ00_03280	COG0653	protein targeting
HZZ00_03305	COG2902	Dehydrogenase
HZZ00_03315	COG1215	transferase activity, transferring glycosyl groups
HZZ00_03320	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HZZ00_03325	COG1134	teichoic acid transport
HZZ00_03325	COG1388	LysM domain
HZZ00_03350	COG1215	transferase activity, transferring glycosyl groups
HZZ00_03365	COG1846	Transcriptional regulator
HZZ00_03370	COG1764	response to oxidative stress
HZZ00_03375	COG1216	Glycosyl transferase, family 2
HZZ00_03380	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HZZ00_03385	COG1216	Glycosyl transferase, family 2
HZZ00_03390	COG0395	ABC-type sugar transport system, permease component
HZZ00_03395	COG1175	transmembrane transport
HZZ00_03400	COG1653	transport
HZZ00_03405	COG1674	ftsk spoiiie
HZZ00_03410	COG0515	serine threonine protein kinase
HZZ00_03415	COG0515	serine threonine protein kinase
HZZ00_03420	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HZZ00_03435	COG2884	Cell division ATP-binding protein ftsE
HZZ00_03440	COG2177	Part of the ABC transporter FtsEX involved in
HZZ00_03445	COG0793	Belongs to the peptidase S41A family
HZZ00_03450	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HZZ00_03465	COG2264	protein methyltransferase activity
HZZ00_03475	COG3973	AAA domain
HZZ00_03485	COG0776	regulation of translation
HZZ00_03490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZZ00_03495	COG1678	Uncharacterized ACR, COG1678
HZZ00_03505	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HZZ00_03565	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HZZ00_03575	COG0277	FAD linked oxidase domain protein
HZZ00_03610	COG1335	isochorismatase
HZZ00_03620	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HZZ00_03630	COG1113	amino acid transport
HZZ00_03665	COG1234	tRNA 3'-trailer cleavage
HZZ00_03670	COG1263	PTS System
HZZ00_03675	COG1263	PTS System
HZZ00_03680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZZ00_03685	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HZZ00_03700	COG4555	ABC transporter
HZZ00_03715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZZ00_03745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HZZ00_03755	COG2733	membrane
HZZ00_03765	COG1733	regulation of RNA biosynthetic process
HZZ00_03775	COG0071	Belongs to the small heat shock protein (HSP20) family
HZZ00_03785	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZZ00_03880	COG0477	Major facilitator Superfamily
HZZ00_03895	COG0706	membrane insertase activity
HZZ00_03910	COG4702	Belongs to the UPF0303 family
HZZ00_03915	COG0673	inositol 2-dehydrogenase activity
HZZ00_03920	COG1940	carbohydrate kinase activity
HZZ00_03940	COG2188	Transcriptional regulator
HZZ00_04005	COG3397	chitin binding
HZZ00_04020	COG1126	abc transporter atp-binding protein
HZZ00_04025	COG0765	amino acid transport
HZZ00_04030	COG0765	amino acid transport
HZZ00_04035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZZ00_04040	COG0154	amidase activity
HZZ00_04055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_04110	COG0406	alpha-ribazole phosphatase activity
HZZ00_04125	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HZZ00_04135	COG0745	RESPONSE REGULATOR receiver
HZZ00_04145	COG3979	chitinase
HZZ00_04170	COG0395	ABC-type sugar transport system, permease component
HZZ00_04190	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HZZ00_04195	COG4977	sequence-specific DNA binding
HZZ00_04205	COG0589	response to stress
HZZ00_04210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZZ00_04240	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HZZ00_04250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZZ00_04290	COG1960	acyl-CoA dehydrogenase activity
HZZ00_04305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZZ00_04310	COG1309	transcriptional regulator
HZZ00_04320	COG1946	Acyl-CoA thioesterase
HZZ00_04340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZZ00_04350	COG0028	Belongs to the TPP enzyme family
HZZ00_04390	COG1472	Belongs to the glycosyl hydrolase 3 family
HZZ00_04410	COG1609	Transcriptional regulator
HZZ00_04430	COG2207	Transcriptional regulator
HZZ00_04460	COG4941	Belongs to the sigma-70 factor family
HZZ00_04470	COG1869	D-ribose catabolic process
HZZ00_04475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZZ00_04485	COG1129	ABC transporter
HZZ00_04500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HZZ00_04535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZZ00_04545	COG3718	enzyme involved in inositol metabolism
HZZ00_04550	COG3962	Belongs to the TPP enzyme family
HZZ00_04565	COG1131	(ABC) transporter
HZZ00_04640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZZ00_04645	COG0515	serine threonine protein kinase
HZZ00_04645	COG2815	serine threonine protein kinase
HZZ00_04665	COG2318	DinB family
HZZ00_04670	COG1733	regulation of RNA biosynthetic process
HZZ00_04675	COG0667	Aldo Keto reductase
HZZ00_04695	COG0629	single-stranded DNA binding
HZZ00_04735	COG1136	(ABC) transporter
HZZ00_04755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZZ00_04785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZZ00_04805	COG1486	melibiose metabolic process
HZZ00_04810	COG0395	ABC-type sugar transport system, permease component
HZZ00_04815	COG1175	transmembrane transport
HZZ00_04825	COG1940	carbohydrate kinase activity
HZZ00_04835	COG0668	transmembrane transport
HZZ00_04850	COG1136	(ABC) transporter
HZZ00_04895	COG2226	methyltransferase
HZZ00_04925	COG2801	Transposase and inactivated derivatives
HZZ00_04925	COG3415	Transposase
HZZ00_04950	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HZZ00_04960	COG0588	phosphoglycerate mutase activity
HZZ00_04965	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HZZ00_04970	COG1113	amino acid transport
HZZ00_04985	COG1116	anion transmembrane transporter activity
HZZ00_04990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZZ00_05000	COG1940	carbohydrate kinase activity
HZZ00_05010	COG1113	amino acid transport
HZZ00_05025	COG4552	Acetyltransferase involved in intracellular survival and related
HZZ00_05040	COG3594	Acyltransferase
HZZ00_05085	COG2188	Transcriptional regulator
HZZ00_05105	COG0544	peptidyl-prolyl cis-trans isomerase activity
HZZ00_05110	COG0740	serine-type endopeptidase activity
HZZ00_05115	COG0740	serine-type endopeptidase activity
HZZ00_05120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HZZ00_05130	COG0525	valine-tRNA ligase activity
HZZ00_05135	COG0285	dihydrofolate synthase activity
HZZ00_05145	COG0105	UTP biosynthetic process
HZZ00_05150	COG1077	Cell shape determining protein MreB Mrl
HZZ00_05165	COG0768	penicillin binding
HZZ00_05170	COG0772	Belongs to the SEDS family
HZZ00_05190	COG1530	ribonuclease E activity
HZZ00_05195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HZZ00_05200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HZZ00_05205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HZZ00_05220	COG1215	transferase activity, transferring glycosyl groups
HZZ00_05230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HZZ00_05240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HZZ00_05255	COG0501	Belongs to the peptidase M48B family
HZZ00_05270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HZZ00_05280	COG0799	negative regulation of ribosome biogenesis
HZZ00_05285	COG0588	phosphoglycerate mutase activity
HZZ00_05305	COG0495	leucyl-tRNA aminoacylation
HZZ00_05315	COG1307	EDD domain protein, DegV family
HZZ00_05320	COG1555	photosystem II stabilization
HZZ00_05335	COG2353	YceI-like domain
HZZ00_05350	COG0268	Binds directly to 16S ribosomal RNA
HZZ00_05355	COG0481	GTPase activity
HZZ00_05360	COG1022	Amp-dependent synthetase and ligase
HZZ00_05385	COG1420	regulation of RNA biosynthetic process
HZZ00_05390	COG0484	heat shock protein binding
HZZ00_05415	COG4946	Tricorn protease homolog
HZZ00_05415	COG0793	Belongs to the peptidase S41A family
HZZ00_05420	COG0537	adenosine 5'-monophosphoramidase activity
HZZ00_05425	COG1234	tRNA 3'-trailer cleavage
HZZ00_05430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HZZ00_05445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HZZ00_05455	COG2315	Protein conserved in bacteria
HZZ00_05460	COG1619	proteins homologs of microcin C7 resistance protein MccF
HZZ00_05480	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HZZ00_05515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZZ00_05585	COG1381	Involved in DNA repair and RecF pathway recombination
HZZ00_05590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HZZ00_05600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZZ00_05605	COG1120	ATPase activity
HZZ00_05610	COG0803	Belongs to the bacterial solute-binding protein 9 family
HZZ00_05610	COG3443	Belongs to the bacterial solute-binding protein 9 family
HZZ00_05615	COG0423	glycine-tRNA ligase activity
HZZ00_05630	COG0667	Aldo Keto reductase
HZZ00_05635	COG1309	transcriptional regulator
HZZ00_05645	COG0477	Major facilitator Superfamily
HZZ00_05680	COG1940	carbohydrate kinase activity
HZZ00_05680	COG1846	Transcriptional regulator
HZZ00_05685	COG0574	Belongs to the PEP-utilizing enzyme family
HZZ00_05685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZZ00_05705	COG1653	transport
HZZ00_05710	COG1175	transmembrane transport
HZZ00_05715	COG0395	ABC-type sugar transport system, permease component
HZZ00_05750	COG4555	ABC transporter
HZZ00_05780	COG3458	cephalosporin-C deacetylase activity
HZZ00_05790	COG2258	MOSC domain
HZZ00_05800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZZ00_05815	COG2949	membrane
HZZ00_05820	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HZZ00_05830	COG0358	DNA primase activity
HZZ00_05835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZZ00_05850	COG1070	Carbohydrate kinase
HZZ00_05900	COG1077	Cell shape determining protein MreB Mrl
HZZ00_05925	COG1404	Belongs to the peptidase S8 family
HZZ00_05930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HZZ00_05930	COG0825	malonyl-CoA metabolic process
HZZ00_05935	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_05975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZZ00_05980	COG2130	NADP-dependent
HZZ00_06005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZZ00_06015	COG0156	8-amino-7-oxononanoate synthase activity
HZZ00_06070	COG1764	response to oxidative stress
HZZ00_06075	COG2130	NADP-dependent
HZZ00_06095	COG1335	isochorismatase
HZZ00_06100	COG1335	isochorismatase
HZZ00_06125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZZ00_06130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZZ00_06135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZZ00_06165	COG0789	Transcriptional regulator
HZZ00_06170	COG0667	Aldo Keto reductase
HZZ00_06185	COG1309	transcriptional regulator
HZZ00_06190	COG0477	Major facilitator Superfamily
HZZ00_06195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HZZ00_06240	COG1358	cellular component organization or biogenesis
HZZ00_06255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZZ00_06300	COG3973	AAA domain
HZZ00_06330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZZ00_06370	COG4122	O-methyltransferase activity
HZZ00_06380	COG0477	Major facilitator Superfamily
HZZ00_06385	COG0477	Major facilitator Superfamily
HZZ00_06395	COG3619	membrane
HZZ00_06415	COG3845	ABC transporter
HZZ00_06470	COG1309	transcriptional regulator
HZZ00_06475	COG0438	transferase activity, transferring glycosyl groups
HZZ00_06500	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZZ00_06510	COG0477	Major facilitator Superfamily
HZZ00_06520	COG2197	response regulator
HZZ00_06530	COG4585	Histidine kinase
HZZ00_06540	COG1131	(ABC) transporter
HZZ00_06545	COG2030	dehydratase
HZZ00_06560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HZZ00_06575	COG0800	Aldolase
HZZ00_06580	COG3022	response to hydroperoxide
HZZ00_06630	COG2259	Doxx family
HZZ00_06650	COG2814	Major facilitator Superfamily
HZZ00_06655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HZZ00_06675	COG0672	)-iron permease
HZZ00_06680	COG2837	iron assimilation
HZZ00_06695	COG0384	phenazine biosynthesis protein PhzF
HZZ00_06730	COG1994	Peptidase M50
HZZ00_06755	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HZZ00_06760	COG0477	Major facilitator Superfamily
HZZ00_06775	COG2814	Major facilitator Superfamily
HZZ00_06845	COG1959	2 iron, 2 sulfur cluster binding
HZZ00_06850	COG1017	nitric oxide dioxygenase activity
HZZ00_06850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZZ00_06855	COG0174	glutamine synthetase
HZZ00_06860	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HZZ00_06895	COG3511	phospholipase C
HZZ00_06910	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HZZ00_06920	COG1609	Transcriptional regulator
HZZ00_06930	COG1175	transmembrane transport
HZZ00_06935	COG3833	ABC-type maltose transport systems, permease component
HZZ00_06940	COG0366	Alpha amylase catalytic
HZZ00_06980	COG2197	response regulator
HZZ00_06995	COG0745	RESPONSE REGULATOR receiver
HZZ00_07030	COG0501	Belongs to the peptidase M48B family
HZZ00_07045	COG0174	glutamine synthetase
HZZ00_07065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HZZ00_07070	COG0321	lipoyl(octanoyl) transferase activity
HZZ00_07110	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HZZ00_07120	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZZ00_07125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZZ00_07130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HZZ00_07135	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HZZ00_07155	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HZZ00_07175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZZ00_07200	COG4585	Histidine kinase
HZZ00_07205	COG2197	response regulator
HZZ00_07210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZZ00_07215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HZZ00_07235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZZ00_07245	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HZZ00_07250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZZ00_07260	COG1376	ErfK ybiS ycfS ynhG family protein
HZZ00_07270	COG1845	cytochrome c oxidase, subunit III
HZZ00_07275	COG2010	Cytochrome c
HZZ00_07280	COG0723	plastoquinol--plastocyanin reductase activity
HZZ00_07285	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HZZ00_07290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZZ00_07295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZZ00_07325	COG0791	NLP P60 protein
HZZ00_07325	COG0741	lytic transglycosylase activity
HZZ00_07340	COG0534	Mate efflux family protein
HZZ00_07350	COG0438	transferase activity, transferring glycosyl groups
HZZ00_07370	COG0003	Pfam Anion-transporting ATPase
HZZ00_07380	COG1940	carbohydrate kinase activity
HZZ00_07405	COG4585	Histidine kinase
HZZ00_07415	COG0205	6-phosphofructokinase activity
HZZ00_07430	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HZZ00_07440	COG2193	ferroxidase activity
HZZ00_07445	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HZZ00_07450	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HZZ00_07455	COG2815	serine threonine protein kinase
HZZ00_07455	COG0515	serine threonine protein kinase
HZZ00_07460	COG2022	thiamine diphosphate biosynthetic process
HZZ00_07470	COG2022	thiamine diphosphate biosynthetic process
HZZ00_07470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZZ00_07490	COG0352	thiamine-phosphate diphosphorylase activity
HZZ00_07515	COG1309	transcriptional regulator
HZZ00_07555	COG0714	Associated with various cellular activities
HZZ00_07565	COG0275	rRNA processing
HZZ00_07575	COG0768	penicillin binding
HZZ00_07580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZZ00_07590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZZ00_07595	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HZZ00_07605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZZ00_07615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HZZ00_07630	COG1799	cell septum assembly
HZZ00_07640	COG3599	regulation of cell shape
HZZ00_07645	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HZZ00_07655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HZZ00_07665	COG2153	protein acetylation
HZZ00_07710	COG0587	DNA-directed DNA polymerase activity
HZZ00_07720	COG1432	Conserved Protein
HZZ00_07740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HZZ00_07745	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZZ00_07760	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HZZ00_07765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZZ00_07770	COG0131	Imidazoleglycerol-phosphate dehydratase
HZZ00_07780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HZZ00_07785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HZZ00_07790	COG0251	oxidation-reduction process
HZZ00_07795	COG0107	imidazoleglycerol-phosphate synthase activity
HZZ00_07810	COG0346	lactoylglutathione lyase activity
HZZ00_07820	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HZZ00_07850	COG0134	indole-3-glycerol-phosphate synthase activity
HZZ00_07855	COG0133	tryptophan synthase activity
HZZ00_07860	COG0159	tryptophan synthase activity
HZZ00_07870	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HZZ00_07875	COG2301	Belongs to the HpcH HpaI aldolase family
HZZ00_07880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZZ00_07885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZZ00_07905	COG1397	ADP-ribosylglycohydrolase
HZZ00_07915	COG0067	glutamate synthase
HZZ00_07915	COG0069	glutamate synthase activity
HZZ00_07915	COG0070	glutamate synthase
HZZ00_07945	COG0287	Prephenate dehydrogenase
HZZ00_07945	COG1605	Chorismate mutase
HZZ00_08010	COG0683	leucine binding
HZZ00_08015	COG2050	protein possibly involved in aromatic compounds catabolism
HZZ00_08040	COG1643	Atp-dependent helicase
HZZ00_08050	COG0539	negative regulation of cytoplasmic translation
HZZ00_08065	COG0237	dephospho-CoA kinase activity
HZZ00_08080	COG2226	methyltransferase
HZZ00_08160	COG0598	Magnesium transport protein CorA
HZZ00_08165	COG2226	methyltransferase
HZZ00_08170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HZZ00_08170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HZZ00_08175	COG2313	pseudouridylate synthase activity
HZZ00_08180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZZ00_08185	COG0584	glycerophosphoryl diester phosphodiesterase
HZZ00_08195	COG0556	nucleotide-excision repair
HZZ00_08215	COG0387	Pfam Sodium calcium exchanger
HZZ00_08220	COG0477	Major facilitator Superfamily
HZZ00_08225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HZZ00_08230	COG1126	abc transporter atp-binding protein
HZZ00_08235	COG0765	amino acid transport
HZZ00_08240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZZ00_08245	COG1733	regulation of RNA biosynthetic process
HZZ00_08250	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_08250	COG3321	synthase
HZZ00_08250	COG0604	alcohol dehydrogenase
HZZ00_08260	COG0583	DNA-binding transcription factor activity
HZZ00_08275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZZ00_08285	COG1609	Transcriptional regulator
HZZ00_08300	COG0322	excinuclease ABC activity
HZZ00_08305	COG1660	Displays ATPase and GTPase activities
HZZ00_08310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HZZ00_08315	COG1481	regulation of sporulation
HZZ00_08320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HZZ00_08325	COG0126	phosphoglycerate kinase activity
HZZ00_08330	COG0149	triose-phosphate isomerase activity
HZZ00_08335	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HZZ00_08345	COG0166	Belongs to the GPI family
HZZ00_08355	COG0363	glucosamine-6-phosphate deaminase activity
HZZ00_08370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZZ00_08380	COG0109	protoheme IX farnesyltransferase activity
HZZ00_08395	COG1612	heme a metabolic process
HZZ00_08405	COG1131	(ABC) transporter
HZZ00_08410	COG2746	aminoglycoside 3-N-acetyltransferase activity
HZZ00_08425	COG0719	Fe-S assembly protein
HZZ00_08435	COG0396	ATPase activity
HZZ00_08440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZZ00_08445	COG0822	iron-sulfur transferase activity
HZZ00_08455	COG2076	Multidrug Resistance protein
HZZ00_08460	COG3226	Transcriptional regulator
HZZ00_08465	COG2171	N-acyltransferase activity
HZZ00_08475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZZ00_08535	COG0395	ABC-type sugar transport system, permease component
HZZ00_08555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZZ00_08585	COG1414	Transcriptional regulator
HZZ00_08605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZZ00_08610	COG5285	phytanoyl-CoA dioxygenase
HZZ00_08615	COG1917	Cupin 2, conserved barrel domain protein
HZZ00_08620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HZZ00_08625	COG0456	acetyltransferase
HZZ00_08630	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HZZ00_08700	COG1797	cobyrinic acid a,c-diamide synthase activity
HZZ00_08720	COG1492	cobalamin metabolic process
HZZ00_08725	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HZZ00_08745	COG0235	Class ii aldolase
HZZ00_08765	COG0488	(ABC) transporter
HZZ00_08775	COG1024	Enoyl-CoA hydratase
HZZ00_08815	COG3387	PFAM Glycoside hydrolase 15-related
HZZ00_08830	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZZ00_08840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZZ00_08845	COG1404	Belongs to the peptidase S8 family
HZZ00_08855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZZ00_08860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HZZ00_08875	COG2261	transglycosylase associated protein
HZZ00_08880	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HZZ00_08910	COG2186	Transcriptional regulator
HZZ00_08925	COG0588	phosphoglycerate mutase activity
HZZ00_08930	COG0560	Phosphoserine phosphatase
HZZ00_08930	COG3830	Belongs to the UPF0237 family
HZZ00_08935	COG0842	Transport permease protein
HZZ00_08935	COG1131	(ABC) transporter
HZZ00_08935	COG1716	ATPase activity
HZZ00_08945	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HZZ00_08950	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_08960	COG2197	response regulator
HZZ00_08975	COG1119	ATPase activity
HZZ00_08995	COG1881	PFAM PEBP family protein
HZZ00_09005	COG2094	Belongs to the DNA glycosylase MPG family
HZZ00_09035	COG0647	UMP catabolic process
HZZ00_09040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZZ00_09045	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZZ00_09050	COG1120	ATPase activity
HZZ00_09070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZZ00_09075	COG2801	Transposase and inactivated derivatives
HZZ00_09075	COG3415	Transposase
HZZ00_09080	COG0497	DNA recombination
HZZ00_09090	COG0297	glycogen (starch) synthase activity
HZZ00_09105	COG3387	PFAM Glycoside hydrolase 15-related
HZZ00_09110	COG0504	CTP synthase activity
HZZ00_09115	COG0494	nUDIX hydrolase
HZZ00_09125	COG0686	Belongs to the AlaDH PNT family
HZZ00_09140	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HZZ00_09145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HZZ00_09150	COG1187	pseudouridine synthase activity
HZZ00_09155	COG1397	ADP-ribosylglycohydrolase
HZZ00_09160	COG3541	Predicted nucleotidyltransferase
HZZ00_09185	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HZZ00_09195	COG1160	GTP binding
HZZ00_09210	COG1652	LysM domain
HZZ00_09220	COG0671	phosphoesterase, PA-phosphatase related
HZZ00_09230	COG0477	Major facilitator Superfamily
HZZ00_09235	COG1960	acyl-CoA dehydrogenase activity
HZZ00_09240	COG1799	cell septum assembly
HZZ00_09250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZZ00_09255	COG0765	amino acid transport
HZZ00_09265	COG1126	abc transporter atp-binding protein
HZZ00_09285	COG0587	DNA-directed DNA polymerase activity
HZZ00_09310	COG2264	protein methyltransferase activity
HZZ00_09325	COG1725	Transcriptional regulator
HZZ00_09345	COG2755	lipolytic protein G-D-S-L family
HZZ00_09355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZZ00_09380	COG2188	Transcriptional regulator
HZZ00_09385	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HZZ00_09395	COG1309	transcriptional regulator
HZZ00_09420	COG0640	Transcriptional regulator
HZZ00_09430	COG1960	acyl-CoA dehydrogenase activity
HZZ00_09480	COG3876	Protein conserved in bacteria
HZZ00_09490	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_09500	COG0583	DNA-binding transcription factor activity
HZZ00_09515	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HZZ00_09545	COG3265	gluconokinase activity
HZZ00_09550	COG2186	Transcriptional regulator
HZZ00_09555	COG3012	SEC-C Motif Domain Protein
HZZ00_09580	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZZ00_09580	COG1796	DNA polymerase
HZZ00_09620	COG0667	Aldo Keto reductase
HZZ00_09625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_09635	COG0598	Magnesium transport protein CorA
HZZ00_09640	COG0406	alpha-ribazole phosphatase activity
HZZ00_09655	COG0215	cysteine-tRNA ligase activity
HZZ00_09665	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HZZ00_09670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HZZ00_09675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HZZ00_09680	COG1414	Transcriptional regulator
HZZ00_09685	COG1410	methionine synthase
HZZ00_09685	COG0646	methionine synthase
HZZ00_09695	COG0747	negative chemotaxis
HZZ00_09700	COG2197	response regulator
HZZ00_09710	COG0517	IMP dehydrogenase activity
HZZ00_09710	COG1994	Peptidase M50
HZZ00_09730	COG1222	aaa ATPase
HZZ00_09735	COG4122	O-methyltransferase activity
HZZ00_09750	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HZZ00_09755	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HZZ00_09760	COG1609	Transcriptional regulator
HZZ00_09770	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HZZ00_09810	COG0805	protein transport
HZZ00_09845	COG0564	pseudouridine synthase activity
HZZ00_09855	COG3629	intracellular signal transduction
HZZ00_09855	COG3903	Transcriptional regulator
HZZ00_09865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZZ00_09870	COG0517	IMP dehydrogenase activity
HZZ00_09870	COG4175	Glycine betaine
HZZ00_09875	COG4176	ABC-type proline glycine betaine transport system permease component
HZZ00_09885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZZ00_09900	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HZZ00_09905	COG2186	Transcriptional regulator
HZZ00_09910	COG0174	glutamine synthetase
HZZ00_09915	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_09950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HZZ00_09955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HZZ00_09960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HZZ00_09965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZZ00_09970	COG5002	protein histidine kinase activity
HZZ00_09975	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HZZ00_09980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZZ00_09980	COG0072	phenylalanine-tRNA ligase activity
HZZ00_09995	COG1051	belongs to the nudix hydrolase family
HZZ00_10015	COG0604	alcohol dehydrogenase
HZZ00_10025	COG1649	PFAM Uncharacterised BCR, COG1649
HZZ00_10055	COG0463	Glycosyl transferase, family 2
HZZ00_10065	COG3903	Transcriptional regulator
HZZ00_10065	COG2197	response regulator
HZZ00_10070	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HZZ00_10085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HZZ00_10090	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HZZ00_10095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HZZ00_10100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZZ00_10105	COG1438	arginine binding
HZZ00_10120	COG1132	(ABC) transporter
HZZ00_10130	COG1477	protein flavinylation
HZZ00_10140	COG1017	nitric oxide dioxygenase activity
HZZ00_10140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZZ00_10145	COG0745	RESPONSE REGULATOR receiver
HZZ00_10150	COG2205	protein histidine kinase activity
HZZ00_10165	COG0137	argininosuccinate synthase activity
HZZ00_10170	COG0165	Argininosuccinate lyase
HZZ00_10180	COG4977	sequence-specific DNA binding
HZZ00_10195	COG0477	Major facilitator Superfamily
HZZ00_10200	COG2132	Multicopper oxidase
HZZ00_10205	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_10205	COG0204	Acyl-transferase
HZZ00_10235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HZZ00_10240	COG2011	ABC-type metal ion transport system permease component
HZZ00_10245	COG1464	Belongs to the NlpA lipoprotein family
HZZ00_10260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HZZ00_10265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZZ00_10265	COG1648	precorrin-2 dehydrogenase activity
HZZ00_10320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HZZ00_10380	COG2176	DNA-directed DNA polymerase activity
HZZ00_10380	COG5002	protein histidine kinase activity
HZZ00_10395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZZ00_10415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZZ00_10420	COG1560	Kdo2-lipid A biosynthetic process
HZZ00_10425	COG0438	transferase activity, transferring glycosyl groups
HZZ00_10435	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HZZ00_10440	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HZZ00_10445	COG0217	transcriptional regulatory protein
HZZ00_10450	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HZZ00_10455	COG0632	four-way junction helicase activity
HZZ00_10460	COG2255	four-way junction helicase activity
HZZ00_10470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZZ00_10475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZZ00_10480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZZ00_10485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZZ00_10490	COG1196	nuclear chromosome segregation
HZZ00_10495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZZ00_10505	COG0124	histidyl-tRNA synthetase
HZZ00_10520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HZZ00_10540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZZ00_10545	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HZZ00_10555	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HZZ00_10560	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HZZ00_10565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HZZ00_10570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HZZ00_10580	COG0006	proline dipeptidase activity
HZZ00_10585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HZZ00_10590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZZ00_10600	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HZZ00_10605	COG0540	Belongs to the ATCase OTCase family
HZZ00_10610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZZ00_10620	COG0505	Belongs to the CarA family
HZZ00_10625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HZZ00_10630	COG0167	dihydroorotate dehydrogenase activity
HZZ00_10635	COG0284	orotidine-5'-phosphate decarboxylase activity
HZZ00_10645	COG0194	GDP metabolic process
HZZ00_10660	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HZZ00_10680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZZ00_10690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZZ00_10695	COG2390	Transcriptional regulator
HZZ00_10720	COG0531	amino acid
HZZ00_10730	COG2188	Transcriptional regulator
HZZ00_10755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZZ00_10775	COG2233	PERMEase
HZZ00_10785	COG0738	Major facilitator superfamily
HZZ00_10790	COG1846	Transcriptional regulator
HZZ00_10790	COG1940	carbohydrate kinase activity
HZZ00_10800	COG3201	nicotinamide mononucleotide transporter
HZZ00_10805	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZZ00_10805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZZ00_10810	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HZZ00_10815	COG0140	phosphoribosyl-ATP diphosphatase activity
HZZ00_10820	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HZZ00_11090	COG1660	Displays ATPase and GTPase activities
HZZ00_11285	COG1216	Glycosyl transferase, family 2
HZZ00_11290	COG3030	protein affecting phage T7 exclusion by the F plasmid
HZZ00_11305	COG2270	Major facilitator Superfamily
HZZ00_11315	COG2364	Membrane
HZZ00_11345	COG0438	transferase activity, transferring glycosyl groups
HZZ00_11350	COG0438	transferase activity, transferring glycosyl groups
HZZ00_11360	COG1984	allophanate hydrolase subunit 2
HZZ00_11365	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HZZ00_11370	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HZZ00_11375	COG4336	lyase activity
HZZ00_11380	COG2814	Major facilitator Superfamily
HZZ00_11405	COG1414	Transcriptional regulator
HZZ00_11420	COG2018	Roadblock/LC7 domain
HZZ00_11455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZZ00_11465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZZ00_11495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZZ00_11515	COG1716	ATPase activity
HZZ00_11535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZZ00_11545	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZZ00_11545	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZZ00_11650	COG0697	spore germination
HZZ00_11685	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_11690	COG0747	negative chemotaxis
HZZ00_11695	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HZZ00_11710	COG2318	DinB family
HZZ00_11715	COG0673	inositol 2-dehydrogenase activity
HZZ00_11720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HZZ00_11745	COG0183	Belongs to the thiolase family
HZZ00_11760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZZ00_11805	COG0110	maltose O-acetyltransferase activity
HZZ00_11815	COG1396	sequence-specific DNA binding
HZZ00_11815	COG1917	Cupin 2, conserved barrel domain protein
HZZ00_11830	COG0640	Transcriptional regulator
HZZ00_11835	COG0531	amino acid
HZZ00_11840	COG1832	CoA-binding protein
HZZ00_11855	COG1739	Uncharacterized protein family UPF0029
HZZ00_11860	COG0420	3'-5' exonuclease activity
HZZ00_11865	COG0419	ATPase involved in DNA repair
HZZ00_11875	COG2124	cytochrome p450
HZZ00_11900	COG0626	cystathionine gamma-synthase activity
HZZ00_11915	COG0596	Alpha beta hydrolase
HZZ00_11925	COG1595	DNA-templated transcription, initiation
HZZ00_11930	COG2188	Transcriptional regulator
HZZ00_11935	COG1940	carbohydrate kinase activity
HZZ00_11950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HZZ00_11970	COG0028	Belongs to the TPP enzyme family
HZZ00_11990	COG0456	acetyltransferase
HZZ00_12005	COG1136	(ABC) transporter
HZZ00_12005	COG0577	efflux transmembrane transporter activity
HZZ00_12020	COG2226	methyltransferase
HZZ00_12025	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HZZ00_12030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZZ00_12035	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZZ00_12070	COG0740	serine-type endopeptidase activity
HZZ00_12090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZZ00_12095	COG1834	amidinotransferase
HZZ00_12100	COG1522	sequence-specific DNA binding
HZZ00_12115	COG0205	6-phosphofructokinase activity
HZZ00_12120	COG3442	glutamine amidotransferase
HZZ00_12130	COG0242	peptide deformylase activity
HZZ00_12140	COG1960	acyl-CoA dehydrogenase activity
HZZ00_12150	COG2124	cytochrome p450
HZZ00_12155	COG3424	synthase
HZZ00_12165	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_12175	COG1793	dna ligase
HZZ00_12180	COG0492	ferredoxin-NADP+ reductase activity
HZZ00_12195	COG1960	acyl-CoA dehydrogenase activity
HZZ00_12200	COG1960	acyl-CoA dehydrogenase activity
HZZ00_12230	COG1063	alcohol dehydrogenase
HZZ00_12255	COG0586	Pfam SNARE associated Golgi protein
HZZ00_12335	COG0464	growth
HZZ00_12345	COG0823	Involved in the tonB-independent uptake of proteins
HZZ00_12345	COG1506	peptidase
HZZ00_12345	COG4946	Tricorn protease homolog
HZZ00_12360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZZ00_12375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZZ00_12410	COG3959	Transketolase, thiamine diphosphate binding domain
HZZ00_12420	COG0443	Heat shock 70 kDa protein
HZZ00_12425	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HZZ00_12440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZZ00_12465	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZZ00_12465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HZZ00_12475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZZ00_12480	COG3938	Belongs to the proline racemase family
HZZ00_12490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZZ00_12505	COG0513	Belongs to the DEAD box helicase family
HZZ00_12510	COG1408	metallophosphoesterase
HZZ00_12520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZZ00_12565	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_12590	COG1940	carbohydrate kinase activity
HZZ00_12590	COG1846	Transcriptional regulator
HZZ00_12640	COG2018	Roadblock/LC7 domain
HZZ00_12650	COG1946	Acyl-CoA thioesterase
HZZ00_12665	COG0254	rRNA binding
HZZ00_12675	COG1132	(ABC) transporter
HZZ00_12705	COG1132	(ABC) transporter
HZZ00_12710	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HZZ00_12715	COG2072	flavoprotein involved in K transport
HZZ00_12720	COG0432	Pfam Uncharacterised protein family UPF0047
HZZ00_12725	COG1119	ATPase activity
HZZ00_12760	COG4245	von Willebrand factor, type A
HZZ00_12785	COG0542	response to heat
HZZ00_12795	COG1100	Small GTP-binding protein
HZZ00_12820	COG0714	Associated with various cellular activities
HZZ00_12845	COG0477	Major facilitator Superfamily
HZZ00_12865	COG2706	6-phosphogluconolactonase activity
HZZ00_12880	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HZZ00_12895	COG1960	acyl-CoA dehydrogenase activity
HZZ00_12910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZZ00_12925	COG1309	transcriptional regulator
HZZ00_12965	COG0584	glycerophosphoryl diester phosphodiesterase
HZZ00_13015	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HZZ00_13050	COG1660	Displays ATPase and GTPase activities
HZZ00_13060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZZ00_13065	COG0445	tRNA wobble uridine modification
HZZ00_13090	COG3631	Ketosteroid isomerase-related protein
HZZ00_13095	COG0702	epimerase
HZZ00_13110	COG0180	Tryptophanyl-tRNA synthetase
HZZ00_13130	COG1349	DNA-binding transcription factor activity
HZZ00_13135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZZ00_13140	COG0191	fructose-bisphosphate aldolase activity
HZZ00_13150	COG0456	acetyltransferase
HZZ00_13155	COG2813	Specifically methylates the guanine in position
HZZ00_13165	COG1940	carbohydrate kinase activity
HZZ00_13200	COG2226	methyltransferase
HZZ00_13210	COG2192	nodulation
HZZ00_13225	COG0492	ferredoxin-NADP+ reductase activity
HZZ00_13230	COG0477	Major facilitator Superfamily
HZZ00_13260	COG1349	DNA-binding transcription factor activity
HZZ00_13295	COG1215	transferase activity, transferring glycosyl groups
HZZ00_13300	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HZZ00_13320	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_13330	COG4191	Histidine kinase
HZZ00_13345	COG3415	Transposase
HZZ00_13345	COG2801	Transposase and inactivated derivatives
HZZ00_13360	COG3469	chitinase activity
HZZ00_13365	COG2340	Cysteine-rich secretory protein family
HZZ00_13370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZZ00_13410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZZ00_13455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HZZ00_13460	COG1993	acr, cog1993
HZZ00_13465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HZZ00_13470	COG1968	undecaprenyl-diphosphatase activity
HZZ00_13490	COG2066	Belongs to the glutaminase family
HZZ00_13505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HZZ00_13510	COG4106	trans-aconitate 2-methyltransferase activity
HZZ00_13520	COG3458	cephalosporin-C deacetylase activity
HZZ00_13535	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HZZ00_13550	COG2890	protein-(glutamine-N5) methyltransferase activity
HZZ00_13570	COG1902	pentaerythritol trinitrate reductase activity
HZZ00_13570	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZZ00_13600	COG1461	Dihydroxyacetone kinase
HZZ00_13605	COG2376	Dihydroxyacetone kinase
HZZ00_13645	COG0464	growth
HZZ00_13665	COG1674	ftsk spoiiie
HZZ00_13680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZZ00_13685	COG2192	nodulation
HZZ00_13695	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HZZ00_13705	COG0438	transferase activity, transferring glycosyl groups
HZZ00_13710	COG0297	glycogen (starch) synthase activity
HZZ00_13715	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HZZ00_13720	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HZZ00_13720	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HZZ00_13775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZZ00_13785	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_13820	COG0510	thiamine kinase activity
HZZ00_13840	COG3511	phospholipase C
HZZ00_13845	COG0673	inositol 2-dehydrogenase activity
HZZ00_13855	COG0367	asparagine synthase
HZZ00_13900	COG3250	beta-galactosidase activity
HZZ00_13905	COG0531	amino acid
HZZ00_13920	COG0667	Aldo Keto reductase
HZZ00_13935	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HZZ00_13945	COG0583	DNA-binding transcription factor activity
HZZ00_13950	COG0667	Aldo Keto reductase
HZZ00_13975	COG1191	sigma factor activity
HZZ00_14000	COG0328	RNA-DNA hybrid ribonuclease activity
HZZ00_14005	COG0667	Aldo Keto reductase
HZZ00_14020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_14025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZZ00_14060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZZ00_14160	COG1252	NADH dehydrogenase
HZZ00_14175	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HZZ00_14180	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZZ00_14185	COG3281	Trehalose synthase
HZZ00_14195	COG0366	Alpha amylase catalytic
HZZ00_14235	COG0842	Transport permease protein
HZZ00_14245	COG0181	hydroxymethylbilane synthase activity
HZZ00_14265	COG1846	Transcriptional regulator
HZZ00_14275	COG4221	oxidoreductase activity
HZZ00_14295	COG0656	L-ascorbic acid biosynthetic process
HZZ00_14310	COG4251	negative regulation of phosphorylation
HZZ00_14320	COG0784	Response regulator, receiver
HZZ00_14340	COG0596	Alpha beta hydrolase
HZZ00_14370	COG0009	L-threonylcarbamoyladenylate synthase
HZZ00_14405	COG0473	3-isopropylmalate dehydrogenase activity
HZZ00_14415	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HZZ00_14510	COG0709	Synthesizes selenophosphate from selenide and ATP
HZZ00_14525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZZ00_14545	COG4106	trans-aconitate 2-methyltransferase activity
HZZ00_14560	COG0437	4 iron, 4 sulfur cluster binding
HZZ00_14565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HZZ00_14595	COG2814	Major facilitator Superfamily
HZZ00_14600	COG0586	Pfam SNARE associated Golgi protein
HZZ00_14610	COG0667	Aldo Keto reductase
HZZ00_14615	COG0477	Major facilitator Superfamily
HZZ00_14655	COG0438	transferase activity, transferring glycosyl groups
HZZ00_14665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZZ00_14670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZZ00_14675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZZ00_14730	COG2050	protein possibly involved in aromatic compounds catabolism
HZZ00_14740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZZ00_14745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZZ00_14750	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_14755	COG1032	radical SAM domain protein
HZZ00_14775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HZZ00_14800	COG1285	pathogenesis
HZZ00_14810	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZZ00_14810	COG1024	Enoyl-CoA hydratase
HZZ00_14815	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HZZ00_14820	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HZZ00_14825	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HZZ00_14830	COG0298	carbon dioxide binding
HZZ00_14845	COG0375	protein maturation
HZZ00_14870	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HZZ00_14905	COG0701	Predicted permease
HZZ00_14915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZZ00_14930	COG0517	IMP dehydrogenase activity
HZZ00_14945	COG0517	IMP dehydrogenase activity
HZZ00_14945	COG0516	GMP reductase activity
HZZ00_14960	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HZZ00_14970	COG2239	Acts as a magnesium transporter
HZZ00_14980	COG0516	GMP reductase activity
HZZ00_14980	COG0517	IMP dehydrogenase activity
HZZ00_15030	COG0640	Transcriptional regulator
HZZ00_15035	COG1316	TRANSCRIPTIONal
HZZ00_15050	COG1090	epimerase
HZZ00_15060	COG2409	Drug exporters of the RND superfamily
HZZ00_15075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZZ00_15125	COG0745	RESPONSE REGULATOR receiver
HZZ00_15130	COG5002	protein histidine kinase activity
HZZ00_15165	COG2080	2 iron, 2 sulfur cluster binding
HZZ00_15170	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HZZ00_15175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZZ00_15195	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZZ00_15210	COG2755	lipolytic protein G-D-S-L family
HZZ00_15215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZZ00_15245	COG1584	GPR1 FUN34 yaaH family protein
HZZ00_15275	COG2197	response regulator
HZZ00_15285	COG0583	DNA-binding transcription factor activity
HZZ00_15315	COG0517	IMP dehydrogenase activity
HZZ00_15315	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HZZ00_15315	COG0617	tRNA 3'-terminal CCA addition
HZZ00_15345	COG0531	amino acid
HZZ00_15430	COG2755	lipolytic protein G-D-S-L family
HZZ00_15470	COG3979	chitinase
HZZ00_15480	COG1177	transmembrane transport
HZZ00_15485	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZZ00_15490	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HZZ00_15495	COG3842	ATPase activity
HZZ00_15515	COG4221	oxidoreductase activity
HZZ00_15525	COG1132	(ABC) transporter
HZZ00_15555	COG0277	FAD linked oxidase domain protein
HZZ00_15560	COG1597	lipid kinase activity
HZZ00_15575	COG2837	iron assimilation
HZZ00_15580	COG0542	response to heat
HZZ00_15585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZZ00_15620	COG1396	sequence-specific DNA binding
HZZ00_15635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HZZ00_15645	COG1554	hydrolase, family 65, central catalytic
HZZ00_15670	COG0456	acetyltransferase
HZZ00_15795	COG1937	Protein conserved in bacteria
HZZ00_15840	COG0438	transferase activity, transferring glycosyl groups
HZZ00_15885	COG1410	methionine synthase
HZZ00_15885	COG0646	methionine synthase
HZZ00_15890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZZ00_15905	COG0736	holo-[acyl-carrier-protein] synthase activity
HZZ00_15920	COG4106	trans-aconitate 2-methyltransferase activity
HZZ00_15935	COG0626	cystathionine gamma-synthase activity
HZZ00_15955	COG2132	Multicopper oxidase
HZZ00_15960	COG1703	isobutyryl-CoA mutase activity
HZZ00_15960	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_15960	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_15980	COG0174	glutamine synthetase
HZZ00_15995	COG4689	acetoacetate decarboxylase
HZZ00_16000	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_16010	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZZ00_16015	COG1309	transcriptional regulator
HZZ00_16025	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_16030	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HZZ00_16035	COG1846	Transcriptional regulator
HZZ00_16040	COG0789	Transcriptional regulator
HZZ00_16050	COG0778	Nitroreductase
HZZ00_16050	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HZZ00_16165	COG0831	urea catabolic process
HZZ00_16170	COG0832	Belongs to the urease beta subunit family
HZZ00_16175	COG0804	urea catabolic process
HZZ00_16180	COG0830	nickel cation binding
HZZ00_16185	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HZZ00_16190	COG0829	nickel cation binding
HZZ00_16205	COG0492	ferredoxin-NADP+ reductase activity
HZZ00_16225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZZ00_16275	COG0477	Major facilitator Superfamily
HZZ00_16345	COG1971	Probably functions as a manganese efflux pump
HZZ00_16355	COG0535	radical SAM domain protein
HZZ00_16370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZZ00_16390	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HZZ00_16395	COG3284	Transcriptional regulator
HZZ00_16440	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_16445	COG1959	2 iron, 2 sulfur cluster binding
HZZ00_16450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZZ00_16455	COG2318	DinB family
HZZ00_16510	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HZZ00_16520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZZ00_16540	COG0667	Aldo Keto reductase
HZZ00_16570	COG0673	inositol 2-dehydrogenase activity
HZZ00_16580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZZ00_16600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZZ00_16610	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HZZ00_16615	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_16625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZZ00_16630	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_16640	COG0789	Transcriptional regulator
HZZ00_16645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZZ00_16650	COG2124	cytochrome p450
HZZ00_16655	COG0475	glutathione-regulated potassium exporter activity
HZZ00_16670	COG0492	ferredoxin-NADP+ reductase activity
HZZ00_16675	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_16680	COG0583	DNA-binding transcription factor activity
HZZ00_16690	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_16740	COG0384	phenazine biosynthesis protein PhzF
HZZ00_16755	COG2770	Histidine kinase
HZZ00_16755	COG2208	phosphoserine phosphatase activity
HZZ00_16780	COG5640	endopeptidase activity
HZZ00_16785	COG0583	DNA-binding transcription factor activity
HZZ00_16795	COG2308	Evidence 4 Homologs of previously reported genes of
HZZ00_16795	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HZZ00_16950	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HZZ00_16980	COG1609	Transcriptional regulator
HZZ00_16995	COG2160	L-arabinose isomerase activity
HZZ00_17005	COG1129	ABC transporter
HZZ00_17035	COG0596	Alpha beta hydrolase
HZZ00_17040	COG2770	Histidine kinase
HZZ00_17040	COG2208	phosphoserine phosphatase activity
HZZ00_17075	COG0745	RESPONSE REGULATOR receiver
HZZ00_17135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HZZ00_17145	COG2353	YceI-like domain
HZZ00_17155	COG4989	oxidoreductase activity
HZZ00_17175	COG0662	Cupin 2, conserved barrel domain protein
HZZ00_17180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HZZ00_17195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZZ00_17200	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HZZ00_17225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HZZ00_17230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HZZ00_17270	COG3833	ABC-type maltose transport systems, permease component
HZZ00_17275	COG0366	Alpha amylase catalytic
HZZ00_17280	COG1609	Transcriptional regulator
HZZ00_17285	COG0395	ABC-type sugar transport system, permease component
HZZ00_17290	COG1175	transmembrane transport
HZZ00_17305	COG1501	Belongs to the glycosyl hydrolase 31 family
HZZ00_17330	COG0604	alcohol dehydrogenase
HZZ00_17415	COG0009	L-threonylcarbamoyladenylate synthase
HZZ00_17425	COG0300	oxidoreductase activity
HZZ00_17470	COG1295	ribonuclease BN
HZZ00_17490	COG0477	Major facilitator Superfamily
HZZ00_17495	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_17520	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_17550	COG1846	Transcriptional regulator
HZZ00_17555	COG0789	Transcriptional regulator
HZZ00_17560	COG2807	transmembrane transport
HZZ00_17600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZZ00_17630	COG2197	response regulator
HZZ00_17640	COG2319	Wd-40 repeat
HZZ00_17640	COG4249	Peptidase C14 caspase catalytic subunit p20
HZZ00_17670	COG2267	carboxylic ester hydrolase activity
HZZ00_17690	COG0444	Belongs to the ABC transporter superfamily
HZZ00_17700	COG0747	negative chemotaxis
HZZ00_17710	COG3458	cephalosporin-C deacetylase activity
HZZ00_17720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZZ00_17730	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HZZ00_17745	COG3537	Alpha-1,2-mannosidase
HZZ00_17750	COG1335	isochorismatase
HZZ00_17815	COG3479	Phenolic acid decarboxylase
HZZ00_17825	COG1725	Transcriptional regulator
HZZ00_17830	COG1131	(ABC) transporter
HZZ00_17845	COG1073	alpha beta
HZZ00_17860	COG3940	Belongs to the glycosyl hydrolase 43 family
HZZ00_17875	COG1349	DNA-binding transcription factor activity
HZZ00_17880	COG2223	nitrite transmembrane transporter activity
HZZ00_17895	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HZZ00_17900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZZ00_17910	COG1737	Transcriptional regulator
HZZ00_17915	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HZZ00_17930	COG0300	oxidoreductase activity
HZZ00_17950	COG0488	(ABC) transporter
HZZ00_17980	COG3842	ATPase activity
HZZ00_17990	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZZ00_17995	COG1177	transmembrane transport
HZZ00_18005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZZ00_18090	COG1349	DNA-binding transcription factor activity
HZZ00_18100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZZ00_18100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZZ00_18100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZZ00_18170	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZZ00_18170	COG1902	pentaerythritol trinitrate reductase activity
HZZ00_18180	COG4249	Peptidase C14 caspase catalytic subunit p20
HZZ00_18180	COG2319	Wd-40 repeat
HZZ00_18185	COG3409	Peptidoglycan-binding domain 1 protein
HZZ00_18215	COG2124	cytochrome p450
HZZ00_18240	COG1335	isochorismatase
HZZ00_18280	COG3293	Transposase
HZZ00_18360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZZ00_18375	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZZ00_18400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZZ00_18405	COG2192	nodulation
HZZ00_18435	COG1132	(ABC) transporter
HZZ00_18440	COG1132	(ABC) transporter
HZZ00_18450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZZ00_18460	COG2124	cytochrome p450
HZZ00_18600	COG0142	geranyltranstransferase activity
HZZ00_19080	COG1278	Cold shock
HZZ00_19175	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZZ00_19190	COG1484	DNA-dependent DNA replication
HZZ00_19265	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_19265	COG3321	synthase
HZZ00_19265	COG0604	alcohol dehydrogenase
HZZ00_19280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZZ00_19305	COG2197	response regulator
HZZ00_19360	COG0484	heat shock protein binding
HZZ00_19420	COG0667	Aldo Keto reductase
HZZ00_19430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZZ00_19475	COG0477	Major facilitator Superfamily
HZZ00_19485	COG1414	Transcriptional regulator
HZZ00_19515	COG3485	protocatechuate 3,4-dioxygenase
HZZ00_19520	COG3485	protocatechuate 3,4-dioxygenase
HZZ00_19525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HZZ00_19530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZZ00_19540	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZZ00_19550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZZ00_19565	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZZ00_19590	COG1132	(ABC) transporter
HZZ00_19610	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZZ00_19620	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_19650	COG1609	Transcriptional regulator
HZZ00_19665	COG1175	transmembrane transport
HZZ00_19670	COG3833	ABC-type maltose transport systems, permease component
HZZ00_19675	COG1733	regulation of RNA biosynthetic process
HZZ00_19680	COG0702	epimerase
HZZ00_19705	COG1960	acyl-CoA dehydrogenase activity
HZZ00_19710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZZ00_19735	COG1228	amidohydrolase
HZZ00_19740	COG0300	oxidoreductase activity
HZZ00_19745	COG1309	transcriptional regulator
HZZ00_19760	COG0300	oxidoreductase activity
HZZ00_19775	COG1309	transcriptional regulator
HZZ00_19785	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_19790	COG2770	Histidine kinase
HZZ00_19790	COG2208	phosphoserine phosphatase activity
HZZ00_19830	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_19835	COG1482	cell wall glycoprotein biosynthetic process
HZZ00_19845	COG0028	Belongs to the TPP enzyme family
HZZ00_19850	COG0069	glutamate synthase activity
HZZ00_19910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_19930	COG0583	DNA-binding transcription factor activity
HZZ00_19960	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZZ00_19965	COG1129	ABC transporter
HZZ00_19970	COG1879	ABC-type sugar transport system periplasmic component
HZZ00_19990	COG1309	transcriptional regulator
HZZ00_20000	COG0583	DNA-binding transcription factor activity
HZZ00_20015	COG4249	Peptidase C14 caspase catalytic subunit p20
HZZ00_20015	COG2319	Wd-40 repeat
HZZ00_20025	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HZZ00_20045	COG0515	serine threonine protein kinase
HZZ00_20045	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZZ00_20050	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_20055	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_20065	COG1309	transcriptional regulator
HZZ00_20070	COG0583	DNA-binding transcription factor activity
HZZ00_20085	COG4257	antibiotic catabolic process
HZZ00_20140	COG1309	transcriptional regulator
HZZ00_20145	COG1609	Transcriptional regulator
HZZ00_20155	COG1175	transmembrane transport
HZZ00_20160	COG0395	ABC-type sugar transport system, permease component
HZZ00_20185	COG4941	Belongs to the sigma-70 factor family
HZZ00_20190	COG3795	YCII-related domain
HZZ00_20195	COG0477	Major facilitator Superfamily
HZZ00_20205	COG0366	Alpha amylase catalytic
HZZ00_20210	COG0395	ABC-type sugar transport system, permease component
HZZ00_20215	COG1175	transmembrane transport
HZZ00_20285	COG3629	intracellular signal transduction
HZZ00_20285	COG3903	Transcriptional regulator
HZZ00_20325	COG0596	Alpha beta hydrolase
HZZ00_20345	COG0589	response to stress
HZZ00_20355	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HZZ00_20360	COG0515	serine threonine protein kinase
HZZ00_20360	COG2815	serine threonine protein kinase
HZZ00_20365	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZZ00_20370	COG2770	Histidine kinase
HZZ00_20370	COG2208	phosphoserine phosphatase activity
HZZ00_20375	COG0488	(ABC) transporter
HZZ00_20380	COG0488	(ABC) transporter
HZZ00_20400	COG2267	carboxylic ester hydrolase activity
HZZ00_20405	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HZZ00_20435	COG2130	NADP-dependent
HZZ00_20445	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_20455	COG0583	DNA-binding transcription factor activity
HZZ00_20480	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZZ00_20500	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_20550	COG0405	Gamma-glutamyltransferase
HZZ00_20575	COG0667	Aldo Keto reductase
HZZ00_20580	COG0789	Transcriptional regulator
HZZ00_20585	COG0577	efflux transmembrane transporter activity
HZZ00_20585	COG1136	(ABC) transporter
HZZ00_20590	COG0577	efflux transmembrane transporter activity
HZZ00_20625	COG2318	DinB family
HZZ00_20660	COG0656	L-ascorbic acid biosynthetic process
HZZ00_20665	COG0438	transferase activity, transferring glycosyl groups
HZZ00_20670	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_20695	COG0789	Transcriptional regulator
HZZ00_20760	COG0589	response to stress
HZZ00_20765	COG2706	6-phosphogluconolactonase activity
HZZ00_20775	COG3387	PFAM Glycoside hydrolase 15-related
HZZ00_20780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZZ00_20785	COG3265	gluconokinase activity
HZZ00_20810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZZ00_20810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZZ00_20820	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZZ00_20825	COG4733	cellulase activity
HZZ00_20825	COG5297	Belongs to the glycosyl hydrolase family 6
HZZ00_20830	COG5297	Belongs to the glycosyl hydrolase family 6
HZZ00_20835	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZZ00_20850	COG0477	Major facilitator Superfamily
HZZ00_20860	COG0477	Major facilitator Superfamily
HZZ00_20865	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_20875	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_20895	COG2072	flavoprotein involved in K transport
HZZ00_20900	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_20915	COG1309	transcriptional regulator
HZZ00_20940	COG1846	Transcriptional regulator
HZZ00_20945	COG2814	Major facilitator Superfamily
HZZ00_20955	COG1366	Belongs to the anti-sigma-factor antagonist family
HZZ00_20960	COG1366	Belongs to the anti-sigma-factor antagonist family
HZZ00_20965	COG2172	sigma factor antagonist activity
HZZ00_20990	COG1982	Orn Lys Arg decarboxylase major
HZZ00_20995	COG1473	amidohydrolase
HZZ00_21020	COG0248	Ppx GppA phosphatase
HZZ00_21050	COG3469	chitinase activity
HZZ00_21070	COG1595	DNA-templated transcription, initiation
HZZ00_21080	COG2814	Major facilitator Superfamily
HZZ00_21135	COG2197	response regulator
HZZ00_21140	COG4585	Histidine kinase
HZZ00_21170	COG0726	polysaccharide deacetylase
HZZ00_21180	COG2264	protein methyltransferase activity
HZZ00_21230	COG0590	tRNA wobble adenosine to inosine editing
HZZ00_21245	COG0583	DNA-binding transcription factor activity
HZZ00_21255	COG3387	PFAM Glycoside hydrolase 15-related
HZZ00_21270	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HZZ00_21285	COG0586	Pfam SNARE associated Golgi protein
HZZ00_21290	COG0671	phosphoesterase, PA-phosphatase related
HZZ00_21305	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZZ00_21315	COG4948	Mandelate Racemase Muconate Lactonizing
HZZ00_21320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZZ00_21325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZZ00_21340	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HZZ00_21405	COG1609	Transcriptional regulator
HZZ00_21410	COG1309	transcriptional regulator
HZZ00_21430	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HZZ00_21455	COG0583	DNA-binding transcription factor activity
HZZ00_21465	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_21495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HZZ00_21520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZZ00_21575	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZZ00_21580	COG0655	NAD(P)H dehydrogenase (quinone) activity
HZZ00_21585	COG2814	Major facilitator Superfamily
HZZ00_21590	COG1309	transcriptional regulator
HZZ00_21605	COG0300	oxidoreductase activity
HZZ00_21615	COG0247	lactate metabolic process
HZZ00_21615	COG0277	FAD linked oxidase domain protein
HZZ00_21625	COG1335	isochorismatase
HZZ00_21685	COG4221	oxidoreductase activity
HZZ00_21705	COG2890	protein-(glutamine-N5) methyltransferase activity
HZZ00_21745	COG1595	DNA-templated transcription, initiation
HZZ00_21770	COG0667	Aldo Keto reductase
HZZ00_21780	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_21800	COG2124	cytochrome p450
HZZ00_21820	COG0435	Glutathione S-transferase
HZZ00_21850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HZZ00_21860	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZZ00_21900	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_21905	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZZ00_21905	COG1796	DNA polymerase
HZZ00_21910	COG0546	phosphoglycolate phosphatase activity
HZZ00_21960	COG2706	6-phosphogluconolactonase activity
HZZ00_21970	COG1309	transcriptional regulator
HZZ00_21980	COG1357	PFAM Pentapeptide repeats (8 copies)
HZZ00_22005	COG0247	lactate metabolic process
HZZ00_22010	COG1139	Iron-sulfur cluster binding protein
HZZ00_22015	COG1556	Lactate utilization protein
HZZ00_22020	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_22055	COG1174	glycine betaine transport
HZZ00_22070	COG0542	response to heat
HZZ00_22080	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HZZ00_22145	COG0596	Alpha beta hydrolase
HZZ00_22155	COG3251	PFAM MbtH domain protein
HZZ00_22175	COG2124	cytochrome p450
HZZ00_22195	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_22225	COG1175	transmembrane transport
HZZ00_22240	COG3507	Belongs to the glycosyl hydrolase 43 family
HZZ00_22265	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZZ00_22265	COG0515	serine threonine protein kinase
HZZ00_22285	COG0791	NLP P60 protein
HZZ00_22285	COG1388	LysM domain
HZZ00_22285	COG3103	Sh3 type 3 domain protein
HZZ00_22300	COG0640	Transcriptional regulator
HZZ00_22310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZZ00_22340	COG3629	intracellular signal transduction
HZZ00_22350	COG2124	cytochrome p450
HZZ00_22360	COG0604	alcohol dehydrogenase
HZZ00_22435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZZ00_22440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZZ00_22455	COG3251	PFAM MbtH domain protein
HZZ00_22465	COG3340	Belongs to the peptidase S51 family
HZZ00_22475	COG2197	response regulator
HZZ00_22500	COG2124	cytochrome p450
HZZ00_22515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZZ00_22525	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HZZ00_22530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZZ00_22535	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZZ00_22540	COG3251	PFAM MbtH domain protein
HZZ00_22545	COG0604	alcohol dehydrogenase
HZZ00_22565	COG1819	glycosyl
HZZ00_22575	COG1024	Enoyl-CoA hydratase
HZZ00_22600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZZ00_22615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZZ00_22620	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_22625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_22630	COG2197	response regulator
HZZ00_22635	COG4585	Histidine kinase
HZZ00_22660	COG3903	Transcriptional regulator
HZZ00_22660	COG3629	intracellular signal transduction
HZZ00_22690	COG0326	Molecular chaperone. Has ATPase activity
HZZ00_22695	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HZZ00_22700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_22735	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HZZ00_22735	COG3608	succinylglutamate desuccinylase aspartoacylase
HZZ00_22750	COG0242	peptide deformylase activity
HZZ00_22755	COG1132	(ABC) transporter
HZZ00_22785	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZZ00_22805	COG1940	carbohydrate kinase activity
HZZ00_22810	COG2814	Major facilitator Superfamily
HZZ00_22815	COG0673	inositol 2-dehydrogenase activity
HZZ00_22820	COG0673	inositol 2-dehydrogenase activity
HZZ00_22830	COG4214	carbohydrate transport
HZZ00_22840	COG4213	ABC transporter substrate-binding protein
HZZ00_22845	COG0596	Alpha beta hydrolase
HZZ00_22855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZZ00_22925	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HZZ00_22930	COG0121	glutamine amidotransferase
HZZ00_22935	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HZZ00_22940	COG2182	Extracellular solute-binding protein
HZZ00_22945	COG3360	Dodecin
HZZ00_22955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_22990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZZ00_23000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZZ00_23005	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HZZ00_23010	COG3971	2-oxopent-4-enoate hydratase activity
HZZ00_23015	COG1414	Transcriptional regulator
HZZ00_23020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HZZ00_23025	COG1053	succinate dehydrogenase
HZZ00_23035	COG0583	DNA-binding transcription factor activity
HZZ00_23100	COG0531	amino acid
HZZ00_23115	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HZZ00_23140	COG0154	amidase activity
HZZ00_23185	COG3537	Alpha-1,2-mannosidase
HZZ00_23205	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HZZ00_23210	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HZZ00_23215	COG2723	6-phospho-beta-galactosidase activity
HZZ00_23220	COG0395	ABC-type sugar transport system, permease component
HZZ00_23225	COG1175	transmembrane transport
HZZ00_23230	COG2182	Extracellular solute-binding protein
HZZ00_23275	COG4948	Mandelate Racemase Muconate Lactonizing
HZZ00_23280	COG0028	Belongs to the TPP enzyme family
HZZ00_23295	COG3387	PFAM Glycoside hydrolase 15-related
HZZ00_23300	COG0028	Belongs to the TPP enzyme family
HZZ00_23305	COG3550	peptidyl-serine autophosphorylation
HZZ00_23325	COG0583	DNA-binding transcription factor activity
HZZ00_23335	COG2814	Major facilitator Superfamily
HZZ00_23340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_23375	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_23460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZZ00_23470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_23480	COG0583	DNA-binding transcription factor activity
HZZ00_23495	COG2124	cytochrome p450
HZZ00_23500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HZZ00_23500	COG2070	2-Nitropropane dioxygenase
HZZ00_23505	COG0300	oxidoreductase activity
HZZ00_23505	COG3321	synthase
HZZ00_23505	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_23505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZZ00_23505	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_23520	COG0477	Major facilitator Superfamily
HZZ00_23535	COG0300	oxidoreductase activity
HZZ00_23535	COG3321	synthase
HZZ00_23535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZZ00_23535	COG4221	oxidoreductase activity
HZZ00_23545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_23570	COG0559	Belongs to the binding-protein-dependent transport system permease family
HZZ00_23610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZZ00_23625	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_23625	COG3321	synthase
HZZ00_23625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZZ00_23625	COG4221	oxidoreductase activity
HZZ00_23640	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_23645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZZ00_23655	COG0456	acetyltransferase
HZZ00_23660	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HZZ00_23680	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZZ00_23705	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZZ00_23710	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HZZ00_23715	COG2080	2 iron, 2 sulfur cluster binding
HZZ00_23720	COG1132	(ABC) transporter
HZZ00_23730	COG1024	Enoyl-CoA hydratase
HZZ00_23745	COG2022	thiamine diphosphate biosynthetic process
HZZ00_23745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZZ00_23750	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HZZ00_23760	COG0531	amino acid
HZZ00_23765	COG0668	transmembrane transport
HZZ00_23775	COG2838	Isocitrate dehydrogenase
HZZ00_23790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZZ00_23800	COG2124	cytochrome p450
HZZ00_23815	COG1404	Belongs to the peptidase S8 family
HZZ00_23845	COG3415	Transposase
HZZ00_23845	COG2801	Transposase and inactivated derivatives
HZZ00_23870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_23875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_23890	COG0765	amino acid transport
HZZ00_23910	COG0531	amino acid
HZZ00_23915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZZ00_23920	COG2197	response regulator
HZZ00_23925	COG4585	Histidine kinase
HZZ00_23975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZZ00_24020	COG3629	intracellular signal transduction
HZZ00_24020	COG3903	Transcriptional regulator
HZZ00_24115	COG1191	sigma factor activity
HZZ00_24130	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HZZ00_24160	COG1609	Transcriptional regulator
HZZ00_24165	COG0673	inositol 2-dehydrogenase activity
HZZ00_24170	COG0673	inositol 2-dehydrogenase activity
HZZ00_24180	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HZZ00_24215	COG0395	ABC-type sugar transport system, permease component
HZZ00_24230	COG1609	Transcriptional regulator
HZZ00_24250	COG1733	regulation of RNA biosynthetic process
HZZ00_24280	COG1011	Hydrolase
HZZ00_24290	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_24295	COG0183	Belongs to the thiolase family
HZZ00_24300	COG2267	carboxylic ester hydrolase activity
HZZ00_24320	COG0561	phosphatase activity
HZZ00_24355	COG0529	Catalyzes the synthesis of activated sulfate
HZZ00_24370	COG3629	intracellular signal transduction
HZZ00_24370	COG3903	Transcriptional regulator
HZZ00_24395	COG3959	Transketolase, thiamine diphosphate binding domain
HZZ00_24400	COG3958	Transketolase
HZZ00_24415	COG0583	DNA-binding transcription factor activity
HZZ00_24420	COG0156	8-amino-7-oxononanoate synthase activity
HZZ00_24425	COG1063	alcohol dehydrogenase
HZZ00_24460	COG2755	lipolytic protein G-D-S-L family
HZZ00_24490	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZZ00_24495	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HZZ00_24520	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HZZ00_24530	COG1562	ergosterol biosynthetic process
HZZ00_24535	COG1134	teichoic acid transport
HZZ00_24580	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HZZ00_24595	COG1024	Enoyl-CoA hydratase
HZZ00_24610	COG2183	response to ionizing radiation
HZZ00_24615	COG0488	(ABC) transporter
HZZ00_24625	COG2936	dipeptidyl-peptidase activity
HZZ00_24635	COG2223	nitrite transmembrane transporter activity
HZZ00_24645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZZ00_24645	COG2146	nitrite reductase [NAD(P)H] activity
HZZ00_24650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZZ00_24655	COG0243	molybdopterin cofactor binding
HZZ00_24660	COG0745	RESPONSE REGULATOR receiver
HZZ00_24675	COG1113	amino acid transport
HZZ00_24685	COG1024	Enoyl-CoA hydratase
HZZ00_24685	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZZ00_24690	COG0183	Belongs to the thiolase family
HZZ00_24695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZZ00_24710	COG1515	deoxyribonuclease V activity
HZZ00_24735	COG0488	(ABC) transporter
HZZ00_24740	COG1834	amidinotransferase
HZZ00_24770	COG1793	dna ligase
HZZ00_24820	COG3511	phospholipase C
HZZ00_24850	COG1486	melibiose metabolic process
HZZ00_24875	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZZ00_24890	COG0166	Belongs to the GPI family
HZZ00_24895	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HZZ00_24900	COG0406	alpha-ribazole phosphatase activity
HZZ00_24915	COG2084	Dehydrogenase
HZZ00_24920	COG3467	pyridoxamine 5'-phosphate
HZZ00_24980	COG0626	cystathionine gamma-synthase activity
HZZ00_24985	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HZZ00_25000	COG3275	phosphorelay sensor kinase activity
HZZ00_25015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZZ00_25020	COG1584	GPR1 FUN34 yaaH family protein
HZZ00_25025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZZ00_25040	COG1414	Transcriptional regulator
HZZ00_25050	COG3142	Participates in the control of copper homeostasis
HZZ00_25060	COG1940	carbohydrate kinase activity
HZZ00_25060	COG1846	Transcriptional regulator
HZZ00_25065	COG0747	negative chemotaxis
HZZ00_25100	COG2124	cytochrome p450
HZZ00_25135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZZ00_25140	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HZZ00_25160	COG0583	DNA-binding transcription factor activity
HZZ00_25170	COG0656	L-ascorbic acid biosynthetic process
HZZ00_25185	COG4221	oxidoreductase activity
HZZ00_25200	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HZZ00_25205	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HZZ00_25210	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HZZ00_25220	COG2226	methyltransferase
HZZ00_25225	COG2154	pterin-4-alpha-carbinolamine dehydratase
HZZ00_25280	COG0028	Belongs to the TPP enzyme family
HZZ00_25295	COG0693	protein deglycase activity
HZZ00_25310	COG0488	(ABC) transporter
HZZ00_25320	COG1597	lipid kinase activity
HZZ00_25380	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HZZ00_25415	COG1619	proteins homologs of microcin C7 resistance protein MccF
HZZ00_25425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZZ00_25430	COG2362	D-Aminopeptidase
HZZ00_25440	COG4106	trans-aconitate 2-methyltransferase activity
HZZ00_25480	COG1309	transcriptional regulator
HZZ00_25495	COG1309	transcriptional regulator
HZZ00_25505	COG2409	Drug exporters of the RND superfamily
HZZ00_25510	COG1063	alcohol dehydrogenase
HZZ00_25525	COG0183	Belongs to the thiolase family
HZZ00_25530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZZ00_25535	COG1024	Enoyl-CoA hydratase
HZZ00_25545	COG1960	acyl-CoA dehydrogenase activity
HZZ00_25550	COG1960	acyl-CoA dehydrogenase activity
HZZ00_25565	COG0604	alcohol dehydrogenase
HZZ00_25580	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_25590	COG1309	transcriptional regulator
HZZ00_25620	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_25630	COG1024	Enoyl-CoA hydratase
HZZ00_25650	COG1024	Enoyl-CoA hydratase
HZZ00_25685	COG0596	Alpha beta hydrolase
HZZ00_25695	COG1295	ribonuclease BN
HZZ00_25710	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZZ00_25720	COG0604	alcohol dehydrogenase
HZZ00_25725	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_25725	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_25730	COG2301	Belongs to the HpcH HpaI aldolase family
HZZ00_25740	COG1960	acyl-CoA dehydrogenase activity
HZZ00_25745	COG0688	phosphatidylethanolamine metabolic process
HZZ00_25755	COG1929	Belongs to the glycerate kinase type-1 family
HZZ00_25770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HZZ00_25785	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZZ00_25795	COG2124	cytochrome p450
HZZ00_25800	COG2124	cytochrome p450
HZZ00_25830	COG0477	Major facilitator Superfamily
HZZ00_25845	COG0483	inositol monophosphate 1-phosphatase activity
HZZ00_25895	COG1953	Uracil, thiamine, allantoin
HZZ00_25905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZZ00_25920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZZ00_25935	COG0542	response to heat
HZZ00_25940	COG0405	Gamma-glutamyltransferase
HZZ00_25955	COG0708	Exodeoxyribonuclease III
HZZ00_25965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZZ00_25970	COG0702	epimerase
HZZ00_26020	COG0783	Belongs to the Dps family
HZZ00_26030	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HZZ00_26035	COG1335	isochorismatase
HZZ00_26040	COG2259	Doxx family
HZZ00_26045	COG3619	membrane
HZZ00_26050	COG2814	Major facilitator Superfamily
HZZ00_26065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_26075	COG0028	Belongs to the TPP enzyme family
HZZ00_26105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZZ00_26110	COG0798	PFAM Bile acid sodium symporter
HZZ00_26115	COG0640	Transcriptional regulator
HZZ00_26120	COG2226	methyltransferase
HZZ00_26135	COG1937	Protein conserved in bacteria
HZZ00_26145	COG0730	response to heat
HZZ00_26155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZZ00_26160	COG2814	Major facilitator Superfamily
HZZ00_26180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZZ00_26190	COG1940	carbohydrate kinase activity
HZZ00_26195	COG1129	ABC transporter
HZZ00_26210	COG2188	Transcriptional regulator
HZZ00_26215	COG0673	inositol 2-dehydrogenase activity
HZZ00_26245	COG4266	Belongs to the allantoicase family
HZZ00_26250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZZ00_26255	COG1414	Transcriptional regulator
HZZ00_26280	COG2340	Cysteine-rich secretory protein family
HZZ00_26290	COG4264	IucA IucC family
HZZ00_26305	COG1733	regulation of RNA biosynthetic process
HZZ00_26310	COG0436	Aminotransferase
HZZ00_26320	COG0406	alpha-ribazole phosphatase activity
HZZ00_26335	COG2233	PERMEase
HZZ00_26350	COG2351	hydroxyisourate hydrolase activity
HZZ00_26370	COG3622	Belongs to the hyi family
HZZ00_26375	COG2084	Dehydrogenase
HZZ00_26380	COG0753	catalase activity
HZZ00_26395	COG3960	tartronate-semialdehyde synthase activity
HZZ00_26405	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_26410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZZ00_26415	COG2197	response regulator
HZZ00_26435	COG0583	DNA-binding transcription factor activity
HZZ00_26445	COG1653	transport
HZZ00_26460	COG0515	serine threonine protein kinase
HZZ00_26470	COG0726	polysaccharide deacetylase
HZZ00_26490	COG2252	PERMEase
HZZ00_26495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZZ00_26525	COG1802	Transcriptional regulator
HZZ00_26540	COG0028	Belongs to the TPP enzyme family
HZZ00_26560	COG2267	carboxylic ester hydrolase activity
HZZ00_26570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZZ00_26585	COG1162	GTPase activity
HZZ00_26605	COG0277	FAD linked oxidase domain protein
HZZ00_26630	COG2040	homocysteine
HZZ00_26645	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HZZ00_26675	COG1960	acyl-CoA dehydrogenase activity
HZZ00_26690	COG0456	acetyltransferase
HZZ00_26705	COG0175	sulfate reduction
HZZ00_26710	COG0529	Catalyzes the synthesis of activated sulfate
HZZ00_26735	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HZZ00_26755	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HZZ00_26795	COG0583	DNA-binding transcription factor activity
HZZ00_26800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZZ00_26830	COG3173	Aminoglycoside phosphotransferase
HZZ00_26890	COG1732	Glycine betaine
HZZ00_26895	COG1174	glycine betaine transport
HZZ00_26900	COG1174	glycine betaine transport
HZZ00_26910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZZ00_26915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZZ00_26955	COG0778	Nitroreductase
HZZ00_26965	COG2326	polyphosphate kinase activity
HZZ00_26970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZZ00_26970	COG0723	plastoquinol--plastocyanin reductase activity
HZZ00_26975	COG0726	polysaccharide deacetylase
HZZ00_26985	COG4152	abc transporter atp-binding protein
HZZ00_26995	COG3220	belongs to the UPF0276 family
HZZ00_27020	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZZ00_27055	COG2267	carboxylic ester hydrolase activity
HZZ00_27065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HZZ00_27080	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HZZ00_27085	COG0183	Belongs to the thiolase family
HZZ00_27090	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZZ00_27090	COG1024	Enoyl-CoA hydratase
HZZ00_27105	COG0531	amino acid
HZZ00_27110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZZ00_27115	COG4214	carbohydrate transport
HZZ00_27125	COG4213	ABC transporter substrate-binding protein
HZZ00_27130	COG1940	carbohydrate kinase activity
HZZ00_27135	COG0395	ABC-type sugar transport system, permease component
HZZ00_27140	COG1175	transmembrane transport
HZZ00_27145	COG1653	transport
HZZ00_27155	COG1556	Lactate utilization protein
HZZ00_27160	COG1139	Iron-sulfur cluster binding protein
HZZ00_27165	COG0247	lactate metabolic process
HZZ00_27170	COG1620	l-lactate permease
HZZ00_27175	COG2186	Transcriptional regulator
HZZ00_27180	COG3290	protein histidine kinase activity
HZZ00_27185	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HZZ00_27200	COG1522	sequence-specific DNA binding
HZZ00_27205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZZ00_27215	COG1309	transcriptional regulator
HZZ00_27260	COG1472	Belongs to the glycosyl hydrolase 3 family
HZZ00_27265	COG0395	ABC-type sugar transport system, permease component
HZZ00_27270	COG1175	transmembrane transport
HZZ00_27275	COG2182	Extracellular solute-binding protein
HZZ00_27280	COG2188	Transcriptional regulator
HZZ00_27295	COG1597	lipid kinase activity
HZZ00_27305	COG0477	Major facilitator Superfamily
HZZ00_27320	COG0477	Major facilitator Superfamily
HZZ00_27360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZZ00_27385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZZ00_27390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZZ00_27395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZZ00_27405	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZZ00_27410	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HZZ00_27415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HZZ00_27420	COG2814	Major facilitator Superfamily
HZZ00_27445	COG3629	intracellular signal transduction
HZZ00_27450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZZ00_27460	COG2801	Transposase and inactivated derivatives
HZZ00_27460	COG3415	Transposase
HZZ00_27495	COG1024	Enoyl-CoA hydratase
HZZ00_27505	COG0531	amino acid
HZZ00_27510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZZ00_27525	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HZZ00_27530	COG2890	protein-(glutamine-N5) methyltransferase activity
HZZ00_27535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_27560	COG1799	cell septum assembly
HZZ00_27605	COG1846	Transcriptional regulator
HZZ00_27625	COG0475	glutathione-regulated potassium exporter activity
HZZ00_27640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZZ00_27660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZZ00_27675	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_27705	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZZ00_27735	COG3629	intracellular signal transduction
HZZ00_27735	COG3903	Transcriptional regulator
HZZ00_27740	COG1136	(ABC) transporter
HZZ00_27750	COG3903	Transcriptional regulator
HZZ00_27750	COG3629	intracellular signal transduction
HZZ00_27755	COG2197	response regulator
HZZ00_27770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZZ00_27780	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZZ00_27795	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZZ00_27850	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HZZ00_27855	COG3845	ABC transporter
HZZ00_27860	COG1122	ATPase activity
HZZ00_27870	COG3345	alpha-galactosidase
HZZ00_27920	COG3654	unkown
HZZ00_27930	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZZ00_27935	COG0531	amino acid
HZZ00_27940	COG0569	domain protein
HZZ00_27970	COG1136	(ABC) transporter
HZZ00_27970	COG4591	ABC-type transport system involved in lipoprotein release permease component
HZZ00_27980	COG0756	dUTP diphosphatase activity
HZZ00_28005	COG2205	protein histidine kinase activity
HZZ00_28010	COG0745	RESPONSE REGULATOR receiver
HZZ00_28020	COG0483	inositol monophosphate 1-phosphatase activity
HZZ00_28060	COG1435	thymidine kinase activity
HZZ00_28080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZZ00_28085	COG1802	Transcriptional regulator
HZZ00_28100	COG0612	Peptidase, M16
HZZ00_28105	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZZ00_28115	COG0372	Belongs to the citrate synthase family
HZZ00_28130	COG3290	protein histidine kinase activity
HZZ00_28140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZZ00_28150	COG4565	transcriptional regulatory protein
HZZ00_28155	COG2801	Transposase and inactivated derivatives
HZZ00_28155	COG3415	Transposase
HZZ00_28160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZZ00_28170	COG2197	response regulator
HZZ00_28185	COG0187	DNA topoisomerase II activity
HZZ00_28210	COG1802	Transcriptional regulator
HZZ00_28215	COG1126	abc transporter atp-binding protein
HZZ00_28235	COG0514	ATP-dependent DNA helicase (RecQ)
HZZ00_28250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HZZ00_28275	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_28285	COG1013	pyruvate-flavodoxin oxidoreductase activity
HZZ00_28290	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HZZ00_28290	COG0674	pyruvate-flavodoxin oxidoreductase activity
HZZ00_28295	COG4865	methylaspartate mutase activity
HZZ00_28320	COG1309	transcriptional regulator
HZZ00_28330	COG0588	phosphoglycerate mutase activity
HZZ00_28345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZZ00_28350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZZ00_28355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZZ00_28385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HZZ00_28395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZZ00_28400	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HZZ00_28410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HZZ00_28430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZZ00_28450	COG2358	TRAP transporter, solute receptor (TAXI family
HZZ00_28455	COG2205	protein histidine kinase activity
HZZ00_28460	COG0745	RESPONSE REGULATOR receiver
HZZ00_28465	COG1126	abc transporter atp-binding protein
HZZ00_28470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZZ00_28475	COG0765	amino acid transport
HZZ00_28480	COG0765	amino acid transport
HZZ00_28495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZZ00_28535	COG1917	Cupin 2, conserved barrel domain protein
HZZ00_28535	COG2207	Transcriptional regulator
HZZ00_28540	COG1201	RNA secondary structure unwinding
HZZ00_28545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HZZ00_28560	COG1396	sequence-specific DNA binding
HZZ00_28565	COG1058	Belongs to the CinA family
HZZ00_28565	COG1546	Belongs to the CinA family
HZZ00_28575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZZ00_28585	COG1674	ftsk spoiiie
HZZ00_28595	COG2205	protein histidine kinase activity
HZZ00_28595	COG0784	Response regulator, receiver
HZZ00_28600	COG2770	Histidine kinase
HZZ00_28600	COG2208	phosphoserine phosphatase activity
HZZ00_28630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HZZ00_28635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZZ00_28640	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HZZ00_28660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HZZ00_28665	COG0612	Peptidase, M16
HZZ00_28670	COG1185	polyribonucleotide nucleotidyltransferase activity
HZZ00_28675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HZZ00_28695	COG1674	ftsk spoiiie
HZZ00_28710	COG1404	Belongs to the peptidase S8 family
HZZ00_28725	COG1404	Belongs to the peptidase S8 family
HZZ00_28745	COG0455	bacterial-type flagellum organization
HZZ00_28760	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HZZ00_28765	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HZZ00_28775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HZZ00_28790	COG0779	Required for maturation of 30S ribosomal subunits
HZZ00_28810	COG0442	prolyl-tRNA aminoacylation
HZZ00_28825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HZZ00_28830	COG0750	zinc metalloprotease
HZZ00_28835	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HZZ00_28880	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_28915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZZ00_28920	COG1177	transmembrane transport
HZZ00_28925	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZZ00_28930	COG3842	ATPase activity
HZZ00_28940	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_28955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HZZ00_28960	COG0584	glycerophosphoryl diester phosphodiesterase
HZZ00_28985	COG3876	Protein conserved in bacteria
HZZ00_29030	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_29040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZZ00_29070	COG3842	ATPase activity
HZZ00_29075	COG4208	sulfate ABC transporter
HZZ00_29085	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HZZ00_29095	COG1064	alcohol dehydrogenase
HZZ00_29105	COG0575	Belongs to the CDS family
HZZ00_29115	COG0233	cytoplasmic translational termination
HZZ00_29120	COG0528	UMP kinase activity
HZZ00_29125	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HZZ00_29130	COG0052	Belongs to the universal ribosomal protein uS2 family
HZZ00_29145	COG1191	sigma factor activity
HZZ00_29160	COG0792	nuclease activity
HZZ00_29180	COG0681	Belongs to the peptidase S26 family
HZZ00_29190	COG0681	Belongs to the peptidase S26 family
HZZ00_29195	COG0335	large ribosomal subunit rRNA binding
HZZ00_29200	COG0336	Belongs to the RNA methyltransferase TrmD family
HZZ00_29205	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HZZ00_29210	COG1837	Belongs to the UPF0109 family
HZZ00_29215	COG0228	four-way junction DNA binding
HZZ00_29225	COG4106	trans-aconitate 2-methyltransferase activity
HZZ00_29230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZZ00_29240	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HZZ00_29270	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HZZ00_29280	COG0477	Major facilitator Superfamily
HZZ00_29285	COG1196	nuclear chromosome segregation
HZZ00_29295	COG1254	Belongs to the acylphosphatase family
HZZ00_29310	COG1733	regulation of RNA biosynthetic process
HZZ00_29315	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HZZ00_29320	COG0571	ribonuclease III activity
HZZ00_29325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HZZ00_29340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HZZ00_29345	COG0742	ribosomal rna small subunit methyltransferase
HZZ00_29355	COG1461	Dihydroxyacetone kinase
HZZ00_29360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HZZ00_29365	COG0351	phosphomethylpyrimidine kinase
HZZ00_29385	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZZ00_29390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HZZ00_29400	COG1920	GTP binding
HZZ00_29410	COG0776	regulation of translation
HZZ00_29420	COG0066	3-isopropylmalate dehydratase activity
HZZ00_29425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZZ00_29430	COG1414	Transcriptional regulator
HZZ00_29475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZZ00_29480	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZZ00_29495	COG5002	protein histidine kinase activity
HZZ00_29500	COG2018	Roadblock/LC7 domain
HZZ00_29520	COG2018	Roadblock/LC7 domain
HZZ00_29540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZZ00_29545	COG2353	YceI-like domain
HZZ00_29575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZZ00_29580	COG0477	Major facilitator Superfamily
HZZ00_29595	COG2957	Belongs to the agmatine deiminase family
HZZ00_29600	COG0804	urea catabolic process
HZZ00_29605	COG0831	urea catabolic process
HZZ00_29605	COG0832	Belongs to the urease beta subunit family
HZZ00_29610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZZ00_29615	COG0473	3-isopropylmalate dehydrogenase activity
HZZ00_29625	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_29635	COG3835	regulator
HZZ00_29660	COG0477	Major facilitator Superfamily
HZZ00_29665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZZ00_29670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HZZ00_29675	COG0440	acetolactate synthase activity
HZZ00_29685	COG5001	Diguanylate cyclase
HZZ00_29685	COG3300	MHYT domain
HZZ00_29695	COG0667	Aldo Keto reductase
HZZ00_29700	COG2133	pyrroloquinoline quinone binding
HZZ00_29710	COG2197	response regulator
HZZ00_29725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZZ00_29730	COG2409	Drug exporters of the RND superfamily
HZZ00_29735	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZZ00_29745	COG0154	amidase activity
HZZ00_29750	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZZ00_29770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZZ00_29780	COG4221	oxidoreductase activity
HZZ00_29800	COG0482	sulfurtransferase activity
HZZ00_29825	COG2378	regulation of single-species biofilm formation
HZZ00_29845	COG2860	membrane
HZZ00_29855	COG4608	Belongs to the ABC transporter superfamily
HZZ00_29860	COG0444	Belongs to the ABC transporter superfamily
HZZ00_29865	COG0601	transmembrane transport
HZZ00_29870	COG0747	negative chemotaxis
HZZ00_29875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZZ00_29895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HZZ00_29900	COG0509	glycine decarboxylation via glycine cleavage system
HZZ00_29905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZZ00_29910	COG1760	l-serine dehydratase
HZZ00_29920	COG1733	regulation of RNA biosynthetic process
HZZ00_29925	COG3409	Peptidoglycan-binding domain 1 protein
HZZ00_29925	COG3757	hydrolase, family 25
HZZ00_29960	COG1024	Enoyl-CoA hydratase
HZZ00_29970	COG1376	ErfK ybiS ycfS ynhG family protein
HZZ00_29990	COG1215	transferase activity, transferring glycosyl groups
HZZ00_30005	COG1132	(ABC) transporter
HZZ00_30010	COG1132	(ABC) transporter
HZZ00_30015	COG1131	(ABC) transporter
HZZ00_30025	COG4585	Histidine kinase
HZZ00_30030	COG2197	response regulator
HZZ00_30035	COG1132	(ABC) transporter
HZZ00_30040	COG1132	(ABC) transporter
HZZ00_30060	COG0058	SHG alpha-glucan phosphorylase activity
HZZ00_30065	COG0366	Alpha amylase catalytic
HZZ00_30075	COG3281	Trehalose synthase
HZZ00_30080	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZZ00_30090	COG3118	belongs to the thioredoxin family
HZZ00_30090	COG0492	ferredoxin-NADP+ reductase activity
HZZ00_30095	COG0789	Transcriptional regulator
HZZ00_30105	COG0477	Major facilitator Superfamily
HZZ00_30115	COG1301	dicarboxylic acid transport
HZZ00_30120	COG3290	protein histidine kinase activity
HZZ00_30125	COG4565	transcriptional regulatory protein
HZZ00_30135	COG1175	transmembrane transport
HZZ00_30140	COG0395	ABC-type sugar transport system, permease component
HZZ00_30145	COG0205	6-phosphofructokinase activity
HZZ00_30150	COG0280	phosphate acetyltransferase
HZZ00_30150	COG0857	belongs to the CobB CobQ family
HZZ00_30155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HZZ00_30190	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_30190	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_30255	COG0183	Belongs to the thiolase family
HZZ00_30275	COG1131	(ABC) transporter
HZZ00_30310	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HZZ00_30315	COG0583	DNA-binding transcription factor activity
HZZ00_30325	COG2814	Major facilitator Superfamily
HZZ00_30350	COG0431	NADPH-dependent FMN reductase
HZZ00_30355	COG2986	histidine ammonia-lyase
HZZ00_30375	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZZ00_30410	COG4585	Histidine kinase
HZZ00_30415	COG2197	response regulator
HZZ00_30430	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HZZ00_30435	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HZZ00_30440	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HZZ00_30445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HZZ00_30450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZZ00_30455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HZZ00_30460	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZZ00_30475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZZ00_30480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZZ00_30485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZZ00_30495	COG2890	protein-(glutamine-N5) methyltransferase activity
HZZ00_30500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HZZ00_30505	COG0254	rRNA binding
HZZ00_30520	COG0083	homoserine kinase activity
HZZ00_30525	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HZZ00_30530	COG0460	homoserine dehydrogenase
HZZ00_30535	COG0019	diaminopimelate decarboxylase activity
HZZ00_30540	COG0018	arginyl-trna synthetase
HZZ00_30540	COG0018	arginyl-trna synthetase
HZZ00_30670	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HZZ00_30675	COG1793	dna ligase
HZZ00_30675	COG3285	dna ligase
HZZ00_30695	COG2205	protein histidine kinase activity
HZZ00_30705	COG0768	penicillin binding
HZZ00_30790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZZ00_30805	COG0745	RESPONSE REGULATOR receiver
HZZ00_30810	COG2205	protein histidine kinase activity
HZZ00_30815	COG0567	Dehydrogenase, E1 component
HZZ00_30815	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZZ00_30835	COG0604	alcohol dehydrogenase
HZZ00_30840	COG0281	malic enzyme
HZZ00_30855	COG1126	abc transporter atp-binding protein
HZZ00_30860	COG4106	trans-aconitate 2-methyltransferase activity
HZZ00_30900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZZ00_30905	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HZZ00_30920	COG2172	sigma factor antagonist activity
HZZ00_30935	COG1597	lipid kinase activity
HZZ00_30950	COG0363	glucosamine-6-phosphate deaminase activity
HZZ00_30955	COG2188	Transcriptional regulator
HZZ00_30990	COG4977	sequence-specific DNA binding
HZZ00_30995	COG2124	cytochrome p450
HZZ00_31005	COG0242	peptide deformylase activity
HZZ00_31015	COG5662	AntiSigma factor
HZZ00_31020	COG1595	DNA-templated transcription, initiation
HZZ00_31030	COG2135	peptidase activity
HZZ00_31040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HZZ00_31045	COG1162	GTPase activity
HZZ00_31050	COG2076	Multidrug Resistance protein
HZZ00_31060	COG0483	inositol monophosphate 1-phosphatase activity
HZZ00_31070	COG0753	catalase activity
HZZ00_31095	COG1615	UPF0182 protein
HZZ00_31105	COG3480	Lon protease (S16) C-terminal proteolytic domain
HZZ00_31160	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HZZ00_31195	COG2816	NAD+ diphosphatase activity
HZZ00_31200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZZ00_31205	COG0210	DNA helicase
HZZ00_31255	COG4172	Belongs to the ABC transporter superfamily
HZZ00_31260	COG0601	transmembrane transport
HZZ00_31265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZZ00_31270	COG0747	negative chemotaxis
HZZ00_31310	COG0513	Belongs to the DEAD box helicase family
HZZ00_31320	COG1432	Conserved Protein
HZZ00_31330	COG2095	MarC family integral membrane protein
HZZ00_31345	COG2814	Major facilitator Superfamily
HZZ00_31355	COG0598	Magnesium transport protein CorA
HZZ00_31390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZZ00_31395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZZ00_31405	COG1595	DNA-templated transcription, initiation
HZZ00_31420	COG1024	Enoyl-CoA hydratase
HZZ00_31425	COG0519	Catalyzes the synthesis of GMP from XMP
HZZ00_31435	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HZZ00_31440	COG1611	Belongs to the LOG family
HZZ00_31445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZZ00_31480	COG2197	response regulator
HZZ00_31485	COG4585	Histidine kinase
HZZ00_31495	COG1131	(ABC) transporter
HZZ00_31510	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HZZ00_31525	COG4608	Belongs to the ABC transporter superfamily
HZZ00_31530	COG0444	Belongs to the ABC transporter superfamily
HZZ00_31540	COG0601	transmembrane transport
HZZ00_31545	COG4166	transmembrane transport
HZZ00_31555	COG0747	negative chemotaxis
HZZ00_31565	COG0444	Belongs to the ABC transporter superfamily
HZZ00_31570	COG4608	Belongs to the ABC transporter superfamily
HZZ00_31580	COG4608	Belongs to the ABC transporter superfamily
HZZ00_31585	COG0444	Belongs to the ABC transporter superfamily
HZZ00_31590	COG0601	transmembrane transport
HZZ00_31595	COG4166	transmembrane transport
HZZ00_31625	COG1053	succinate dehydrogenase
HZZ00_31695	COG0515	serine threonine protein kinase
HZZ00_31730	COG1454	alcohol dehydrogenase
HZZ00_31735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZZ00_31750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_31780	COG0745	RESPONSE REGULATOR receiver
HZZ00_31785	COG2205	protein histidine kinase activity
HZZ00_31815	COG1192	Involved in chromosome partitioning
HZZ00_31845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZZ00_31860	COG0012	GTP binding
HZZ00_31875	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZZ00_31880	COG1570	exodeoxyribonuclease VII activity
HZZ00_31885	COG1722	exodeoxyribonuclease VII activity
HZZ00_31890	COG0778	Nitroreductase
HZZ00_31915	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HZZ00_31915	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HZZ00_31920	COG0114	fumarate hydratase activity
HZZ00_31935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZZ00_31945	COG1136	(ABC) transporter
HZZ00_31960	COG0450	alkyl hydroperoxide reductase
HZZ00_31965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZZ00_31980	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HZZ00_31985	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HZZ00_31990	COG2226	methyltransferase
HZZ00_32000	COG2885	chlorophyll binding
HZZ00_32015	COG2197	response regulator
HZZ00_32020	COG3850	Histidine kinase
HZZ00_32050	COG2894	cell division
HZZ00_32085	COG2610	gluconate transmembrane transporter activity
HZZ00_32090	COG0251	oxidation-reduction process
HZZ00_32095	COG1414	Transcriptional regulator
HZZ00_32110	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HZZ00_32125	COG0436	Aminotransferase
HZZ00_32135	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HZZ00_32140	COG1272	protein, Hemolysin III
HZZ00_32145	COG1309	transcriptional regulator
HZZ00_32160	COG1331	Highly conserved protein containing a thioredoxin domain
HZZ00_32185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HZZ00_32195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZZ00_32200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZZ00_32240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZZ00_32245	COG1064	alcohol dehydrogenase
HZZ00_32255	COG1136	(ABC) transporter
HZZ00_32285	COG2986	histidine ammonia-lyase
HZZ00_32295	COG1024	Enoyl-CoA hydratase
HZZ00_32305	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HZZ00_32315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZZ00_32325	COG0424	maF-like protein
HZZ00_32335	COG4770	biotin carboxylase activity
HZZ00_32365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZZ00_32410	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_32415	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_32445	COG1595	DNA-templated transcription, initiation
HZZ00_32450	COG0745	RESPONSE REGULATOR receiver
HZZ00_32455	COG2205	protein histidine kinase activity
HZZ00_32480	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HZZ00_32490	COG0583	DNA-binding transcription factor activity
HZZ00_32495	COG2814	Major facilitator Superfamily
HZZ00_32500	COG0592	DNA-directed DNA polymerase activity
HZZ00_32545	COG1473	amidohydrolase
HZZ00_32545	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HZZ00_32585	COG2089	acid synthase
HZZ00_32600	COG1216	Glycosyl transferase, family 2
HZZ00_32630	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_32630	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_32640	COG1595	DNA-templated transcription, initiation
HZZ00_32670	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HZZ00_32680	COG2009	succinate dehydrogenase
HZZ00_32690	COG1053	succinate dehydrogenase
HZZ00_32710	COG1309	transcriptional regulator
HZZ00_32730	COG1295	ribonuclease BN
HZZ00_32745	COG0180	Tryptophanyl-tRNA synthetase
HZZ00_32750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZZ00_32760	COG0754	glutathionylspermidine amidase activity
HZZ00_32780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZZ00_32785	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZZ00_32800	COG4176	ABC-type proline glycine betaine transport system permease component
HZZ00_32805	COG4175	Glycine betaine
HZZ00_32805	COG0517	IMP dehydrogenase activity
HZZ00_32815	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_32820	COG0039	L-malate dehydrogenase activity
HZZ00_32835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HZZ00_32845	COG0138	bifunctional purine biosynthesis protein purh
HZZ00_32875	COG0045	succinate-CoA ligase (ADP-forming) activity
HZZ00_32880	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HZZ00_32890	COG0714	Associated with various cellular activities
HZZ00_32905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_32905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_32910	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HZZ00_32935	COG0791	NLP P60 protein
HZZ00_32940	COG2197	response regulator
HZZ00_32980	COG0519	Catalyzes the synthesis of GMP from XMP
HZZ00_32980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZZ00_32995	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_33000	COG0515	serine threonine protein kinase
HZZ00_33005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZZ00_33015	COG0515	serine threonine protein kinase
HZZ00_33020	COG0515	serine threonine protein kinase
HZZ00_33025	COG0515	serine threonine protein kinase
HZZ00_33025	COG2815	serine threonine protein kinase
HZZ00_33035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HZZ00_33050	COG0516	GMP reductase activity
HZZ00_33060	COG1595	DNA-templated transcription, initiation
HZZ00_33065	COG2197	response regulator
HZZ00_33075	COG0583	DNA-binding transcription factor activity
HZZ00_33085	COG4221	oxidoreductase activity
HZZ00_33100	COG0459	protein refolding
HZZ00_33110	COG0726	polysaccharide deacetylase
HZZ00_33115	COG0726	polysaccharide deacetylase
HZZ00_33130	COG1609	Transcriptional regulator
HZZ00_33135	COG1653	transport
HZZ00_33140	COG1175	transmembrane transport
HZZ00_33150	COG1472	Belongs to the glycosyl hydrolase 3 family
HZZ00_33165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HZZ00_33185	COG0802	atpase or kinase
HZZ00_33195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZZ00_33205	COG0736	holo-[acyl-carrier-protein] synthase activity
HZZ00_33210	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_33215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZZ00_33220	COG1072	(Pantothenic acid kinase))
HZZ00_33230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZZ00_33235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HZZ00_33240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HZZ00_33250	COG0101	tRNA pseudouridine synthase activity
HZZ00_33255	COG0203	ribosomal protein L17
HZZ00_33260	COG0202	RNA polymerase activity
HZZ00_33265	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HZZ00_33270	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HZZ00_33275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HZZ00_33280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HZZ00_33290	COG0563	adenylate kinase activity
HZZ00_33300	COG0200	Binds to the 23S rRNA
HZZ00_33305	COG1841	ribosomal large subunit assembly
HZZ00_33310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HZZ00_33315	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HZZ00_33320	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HZZ00_33325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HZZ00_33330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HZZ00_33335	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HZZ00_33340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HZZ00_33345	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HZZ00_33350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HZZ00_33355	COG0255	Belongs to the universal ribosomal protein uL29 family
HZZ00_33360	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HZZ00_33365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HZZ00_33370	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HZZ00_33375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HZZ00_33380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HZZ00_33385	COG0089	rRNA binding
HZZ00_33390	COG0088	Forms part of the polypeptide exit tunnel
HZZ00_33395	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HZZ00_33400	COG0051	transcription antitermination factor activity, RNA binding
HZZ00_33460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZZ00_33465	COG0049	tRNA binding
HZZ00_33470	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HZZ00_33475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZZ00_33505	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HZZ00_33510	COG0085	RNA polymerase activity
HZZ00_33520	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HZZ00_33530	COG0081	regulation of translation
HZZ00_33540	COG0250	Participates in transcription elongation, termination and antitermination
HZZ00_33555	COG0436	Aminotransferase
HZZ00_33560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HZZ00_33565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HZZ00_33600	COG2030	dehydratase
HZZ00_33605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZZ00_33625	COG0702	epimerase
HZZ00_33640	COG4191	Histidine kinase
HZZ00_33690	COG1666	GTP binding
HZZ00_33695	COG2261	transglycosylase associated protein
HZZ00_33710	COG0501	Belongs to the peptidase M48B family
HZZ00_33715	COG1007	ATP synthesis coupled electron transport
HZZ00_33725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZZ00_33730	COG0713	ATP synthesis coupled electron transport
HZZ00_33735	COG0839	Belongs to the complex I subunit 6 family
HZZ00_33740	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZZ00_33745	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HZZ00_33750	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZZ00_33755	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZZ00_33760	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZZ00_33780	COG0674	pyruvate-flavodoxin oxidoreductase activity
HZZ00_33780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HZZ00_33785	COG1013	pyruvate-flavodoxin oxidoreductase activity
HZZ00_33810	COG3953	SLT domain
HZZ00_33810	COG5412	phage tail tape measure protein
HZZ00_33815	COG0561	phosphatase activity
HZZ00_33830	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HZZ00_33835	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HZZ00_33855	COG1007	ATP synthesis coupled electron transport
HZZ00_33865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZZ00_33870	COG0713	ATP synthesis coupled electron transport
HZZ00_33875	COG0839	Belongs to the complex I subunit 6 family
HZZ00_33880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZZ00_33885	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HZZ00_33890	COG1034	ATP synthesis coupled electron transport
HZZ00_33895	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HZZ00_33905	COG0649	NAD binding
HZZ00_33910	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZZ00_33915	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZZ00_33930	COG0242	peptide deformylase activity
HZZ00_33950	COG2226	methyltransferase
HZZ00_33960	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HZZ00_33975	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HZZ00_33985	COG2226	methyltransferase
HZZ00_34000	COG3629	intracellular signal transduction
HZZ00_34040	COG1309	transcriptional regulator
HZZ00_34055	COG1573	uracil-dna glycosylase
HZZ00_34060	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HZZ00_34070	COG0163	prenyltransferase activity
HZZ00_34075	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HZZ00_34080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HZZ00_34125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZZ00_34130	COG1333	cytochrome c biogenesis protein
HZZ00_34135	COG0785	Cytochrome C biogenesis protein
HZZ00_34150	COG0406	alpha-ribazole phosphatase activity
HZZ00_34155	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZZ00_34175	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_34195	COG2362	D-Aminopeptidase
HZZ00_34205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZZ00_34205	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HZZ00_34210	COG2205	protein histidine kinase activity
HZZ00_34225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_34230	COG1742	UPF0060 membrane protein
HZZ00_34255	COG1690	Belongs to the RtcB family
HZZ00_34275	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HZZ00_34280	COG0018	arginyl-trna synthetase
HZZ00_34320	COG2910	NAD(P)H-binding
HZZ00_34325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_34330	COG0113	porphobilinogen synthase activity
HZZ00_34345	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HZZ00_34370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZZ00_34370	COG1648	precorrin-2 dehydrogenase activity
HZZ00_34375	COG0181	hydroxymethylbilane synthase activity
HZZ00_34380	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HZZ00_34385	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HZZ00_34435	COG0123	including yeast histone deacetylase and acetoin utilization protein
HZZ00_34440	COG2223	nitrite transmembrane transporter activity
HZZ00_34470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HZZ00_34485	COG4991	sh3 domain protein
HZZ00_34490	COG0515	serine threonine protein kinase
HZZ00_34490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZZ00_34495	COG0129	dihydroxy-acid dehydratase activity
HZZ00_34505	COG1082	Xylose isomerase domain protein TIM barrel
HZZ00_34510	COG0248	Ppx GppA phosphatase
HZZ00_34530	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HZZ00_34540	COG1194	a g-specific adenine glycosylase
HZZ00_34545	COG1595	DNA-templated transcription, initiation
HZZ00_34555	COG0745	RESPONSE REGULATOR receiver
HZZ00_34560	COG2205	protein histidine kinase activity
HZZ00_34580	COG0477	Major facilitator Superfamily
HZZ00_34590	COG0739	heme binding
HZZ00_34620	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HZZ00_34640	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HZZ00_34650	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HZZ00_34655	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HZZ00_34665	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HZZ00_34680	COG2197	response regulator
HZZ00_34695	COG0649	NAD binding
HZZ00_34710	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZZ00_34710	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HZZ00_34725	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HZZ00_34740	COG0302	gtp cyclohydrolase
HZZ00_34755	COG0037	tRNA processing
HZZ00_34765	COG2027	D-alanyl-D-alanine carboxypeptidase
HZZ00_34770	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HZZ00_34785	COG0393	Putative heavy-metal-binding
HZZ00_34790	COG0789	Transcriptional regulator
HZZ00_34795	COG0076	glutamate decarboxylase activity
HZZ00_34800	COG2318	DinB family
HZZ00_34805	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_34845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZZ00_34845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZZ00_34850	COG3629	intracellular signal transduction
HZZ00_34850	COG3903	Transcriptional regulator
HZZ00_34860	COG0673	inositol 2-dehydrogenase activity
HZZ00_34865	COG5297	Belongs to the glycosyl hydrolase family 6
HZZ00_34875	COG0604	alcohol dehydrogenase
HZZ00_34895	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
HZZ00_34905	COG0406	alpha-ribazole phosphatase activity
HZZ00_34910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZZ00_35025	COG4974	Belongs to the 'phage' integrase family
HZZ00_35045	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZZ00_35050	COG1754	DNA topoisomerase type I activity
HZZ00_35050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZZ00_35070	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HZZ00_35075	COG2172	sigma factor antagonist activity
HZZ00_35080	COG1366	Belongs to the anti-sigma-factor antagonist family
HZZ00_35085	COG1111	helicase
HZZ00_35085	COG1205	dead DEAH box helicase
HZZ00_35145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZZ00_35160	COG2267	carboxylic ester hydrolase activity
HZZ00_35195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZZ00_35220	COG0003	Pfam Anion-transporting ATPase
HZZ00_35240	COG1408	metallophosphoesterase
HZZ00_35295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZZ00_35310	COG1937	Protein conserved in bacteria
HZZ00_35370	COG0583	DNA-binding transcription factor activity
HZZ00_35380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZZ00_35390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HZZ00_35400	COG1309	transcriptional regulator
HZZ00_35415	COG1802	Transcriptional regulator
HZZ00_35420	COG4552	Acetyltransferase involved in intracellular survival and related
HZZ00_35430	COG1490	D-aminoacyl-tRNA deacylase activity
HZZ00_35445	COG3485	protocatechuate 3,4-dioxygenase
HZZ00_35470	COG2897	thiosulfate sulfurtransferase activity
HZZ00_35535	COG0745	RESPONSE REGULATOR receiver
HZZ00_35540	COG1609	Transcriptional regulator
HZZ00_35545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZZ00_35555	COG0745	RESPONSE REGULATOR receiver
HZZ00_35565	COG0456	acetyltransferase
HZZ00_35570	COG1725	Transcriptional regulator
HZZ00_35575	COG3842	ATPase activity
HZZ00_35585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HZZ00_35615	COG1937	Protein conserved in bacteria
HZZ00_35625	COG0306	phosphate transporter
HZZ00_35630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZZ00_35650	COG0277	FAD linked oxidase domain protein
HZZ00_35655	COG0671	phosphoesterase, PA-phosphatase related
HZZ00_35660	COG0791	NLP P60 protein
HZZ00_35685	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_35690	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_35780	COG1252	NADH dehydrogenase
HZZ00_35810	COG0579	oxidoreductase
HZZ00_35815	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HZZ00_35840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZZ00_35840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZZ00_35875	COG0513	Belongs to the DEAD box helicase family
HZZ00_35920	COG1643	Atp-dependent helicase
HZZ00_35950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HZZ00_35970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZZ00_35975	COG0047	phosphoribosylformylglycinamidine synthase activity
HZZ00_35980	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZZ00_36005	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HZZ00_36020	COG0151	Belongs to the GarS family
HZZ00_36060	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_36100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HZZ00_36135	COG1191	sigma factor activity
HZZ00_36140	COG1191	sigma factor activity
HZZ00_36170	COG3467	pyridoxamine 5'-phosphate
HZZ00_36180	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HZZ00_36190	COG2205	protein histidine kinase activity
HZZ00_36195	COG0745	RESPONSE REGULATOR receiver
HZZ00_36235	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_36240	COG1595	DNA-templated transcription, initiation
HZZ00_36310	COG0653	protein targeting
HZZ00_36330	COG0006	proline dipeptidase activity
HZZ00_36355	COG1999	signal sequence binding
HZZ00_36370	COG2837	iron assimilation
HZZ00_36380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZZ00_36385	COG0561	phosphatase activity
HZZ00_36410	COG1131	(ABC) transporter
HZZ00_36425	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HZZ00_36435	COG0561	phosphatase activity
HZZ00_36440	COG4988	ABC transporter
HZZ00_36445	COG1294	oxidase, subunit
HZZ00_36450	COG1271	oxidase subunit
HZZ00_36455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZZ00_36460	COG1609	Transcriptional regulator
HZZ00_36475	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HZZ00_36500	COG0662	Cupin 2, conserved barrel domain protein
HZZ00_36505	COG1950	PFAM Membrane protein of
HZZ00_36510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZZ00_36515	COG0626	cystathionine gamma-synthase activity
HZZ00_36540	COG2814	Major facilitator Superfamily
HZZ00_36565	COG0305	Participates in initiation and elongation during chromosome replication
HZZ00_36575	COG0359	binds to the 23S rRNA
HZZ00_36580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HZZ00_36585	COG0629	single-stranded DNA binding
HZZ00_36590	COG0360	Binds together with S18 to 16S ribosomal RNA
HZZ00_36615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZZ00_36635	COG0617	tRNA 3'-terminal CCA addition
HZZ00_36660	COG1473	amidohydrolase
HZZ00_36685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZZ00_36690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZZ00_36700	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZZ00_36710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HZZ00_36725	COG1741	Belongs to the pirin family
HZZ00_36735	COG1960	acyl-CoA dehydrogenase activity
HZZ00_36740	COG1362	aminopeptidase activity
HZZ00_36775	COG2271	Major facilitator Superfamily
HZZ00_36845	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZZ00_36850	COG0022	dehydrogenase e1 component
HZZ00_36865	COG0515	serine threonine protein kinase
HZZ00_36870	COG0515	serine threonine protein kinase
HZZ00_36885	COG0604	alcohol dehydrogenase
HZZ00_36885	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_36885	COG3321	synthase
HZZ00_36890	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZZ00_36920	COG1522	sequence-specific DNA binding
HZZ00_36925	COG1309	transcriptional regulator
HZZ00_36930	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZZ00_36955	COG3396	Phenylacetate-CoA oxygenase
HZZ00_36960	COG3460	Phenylacetate-CoA oxygenase
HZZ00_36965	COG3396	Phenylacetate-CoA oxygenase
HZZ00_36970	COG2151	metal-sulfur cluster biosynthetic enzyme
HZZ00_36975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZZ00_37000	COG0477	Major facilitator Superfamily
HZZ00_37010	COG1716	ATPase activity
HZZ00_37015	COG1716	ATPase activity
HZZ00_37035	COG0515	serine threonine protein kinase
HZZ00_37040	COG3764	Sortase (surface protein transpeptidase)
HZZ00_37045	COG3764	Sortase (surface protein transpeptidase)
HZZ00_37070	COG0705	Rhomboid family
HZZ00_37110	COG0515	serine threonine protein kinase
HZZ00_37140	COG4249	Peptidase C14 caspase catalytic subunit p20
HZZ00_37140	COG2319	Wd-40 repeat
HZZ00_37170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZZ00_37175	COG0187	DNA topoisomerase II activity
HZZ00_37180	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HZZ00_37185	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZZ00_37190	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HZZ00_37195	COG0592	DNA-directed DNA polymerase activity
HZZ00_37260	COG2188	Transcriptional regulator
HZZ00_37370	COG2188	Transcriptional regulator
HZZ00_37750	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HZZ00_37845	COG0629	single-stranded DNA binding
HZZ00_38000	COG0305	Participates in initiation and elongation during chromosome replication