locus-tag class description FNV58_00155 ENOG4105FA0 parb-like partition protein FNV58_00170 ENOG4105VEQ Cold shock protein FNV58_00215 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FNV58_00260 ENOG4105CJ1 ABC, transporter FNV58_00305 ENOG4105K59 histidine triad (HIT) protein FNV58_00430 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FNV58_00455 ENOG4105CDU Replicative dna helicase FNV58_00475 ENOG4108VWQ crispr-associated protein FNV58_00480 ENOG41060M0 Crispr-associated protein, cse4 family FNV58_00635 ENOG4105K7W phage-related replication protein FNV58_00750 ENOG4105C0B DNA polymerase III (alpha subunit) FNV58_00765 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FNV58_01270 ENOG4105DHP deoxycytidine triphosphate deaminase FNV58_01315 ENOG4105QNJ serralysin (EC 3.4.24.40) FNV58_01315 ENOG4105QNJ serralysin (EC 3.4.24.40) FNV58_01505 ENOG4105VEQ Cold shock protein FNV58_01590 ENOG4105IIV Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) FNV58_01605 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_01650 ENOG4105CIR epoxide hydrolase FNV58_01705 ENOG4108YIQ Alpha beta hydrolase FNV58_01765 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FNV58_01975 ENOG4108Z40 Transcriptional regulator FNV58_02130 ENOG4106A3M Cytochrome p-450 FNV58_02200 ENOG4105KVH Transcriptional regulator FNV58_02205 ENOG4105CIS alcohol dehydrogenase FNV58_02220 ENOG4105FDF Could be involved in DNA repair (By similarity) FNV58_02320 ENOG4105CHH sulfate transporter FNV58_02330 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FNV58_02370 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV58_02410 ENOG4105K5X acetyltransferase FNV58_02490 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) FNV58_02495 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_02545 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FNV58_02615 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FNV58_02635 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FNV58_02655 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FNV58_02665 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FNV58_02680 ENOG4107RDB Major Facilitator FNV58_02720 ENOG4105FDF Could be involved in DNA repair (By similarity) FNV58_02725 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) FNV58_02790 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FNV58_02830 ENOG4105BZU Histidine kinase FNV58_02835 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_02855 ENOG4105VEQ Cold shock protein FNV58_02870 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FNV58_02875 ENOG4108N5B 2-phosphosulfolactate phosphatase FNV58_03085 ENOG4105DWV Homoserine O-trans-acetylase FNV58_03095 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FNV58_03110 ENOG4107RSM transcriptional regulator FNV58_03115 ENOG4105CHR reductase FNV58_03120 ENOG4105NAE bifunctional deaminase-reductase domain protein FNV58_03135 ENOG4105MP0 transposase FNV58_03150 ENOG4105MHT Transcriptional regulator, ARSR family FNV58_03170 ENOG4108YYQ gCN5-related N-acetyltransferase FNV58_03180 ENOG4105ETE Transcriptional regulator (LacI family FNV58_03185 ENOG4105CS2 ec 3.2.1.21 FNV58_03200 ENOG4105CNT hydrolase family 2 FNV58_03205 ENOG4105CNT hydrolase family 2 FNV58_03220 ENOG4105DSG hydrolase family 43 FNV58_03240 ENOG4105CHR reductase FNV58_03330 ENOG4105DA5 (ABC) transporter FNV58_03425 ENOG4105RKW reductase (By FNV58_03435 ENOG4108IND Tetr family transcriptional regulator FNV58_03485 ENOG4105KNA -acetyltransferase FNV58_03510 ENOG4105F44 Two component transcriptional regulator, winged helix family FNV58_03515 ENOG4106F60 Histidine kinase FNV58_03570 ENOG4108XG2 Histidine kinase FNV58_03575 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_03580 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FNV58_03585 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FNV58_03605 ENOG4105ECP epimerase FNV58_03610 ENOG4108KPJ rna polymerase sigma factor FNV58_03630 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) FNV58_03640 ENOG4105C1G acyl-Coa dehydrogenase FNV58_03645 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FNV58_03670 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) FNV58_03675 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FNV58_03680 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase FNV58_03710 ENOG4105CPQ Dehydrogenase FNV58_03715 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FNV58_03755 ENOG4108SGK Tetr family transcriptional regulator FNV58_03770 ENOG4105I1F Resistance protein FNV58_03785 ENOG4105EV9 Alpha Beta Hydrolase FNV58_03930 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth FNV58_03945 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) FNV58_03955 ENOG4107ETC gas vesicle protein FNV58_03960 ENOG4108XNA Gas vesicle FNV58_03970 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FNV58_03990 ENOG4105CBC glutamate synthase FNV58_03995 ENOG4105C7K acetolactate synthase FNV58_04000 ENOG4107R6F Alpha Beta Hydrolase Fold protein FNV58_04010 ENOG4105WN5 stage II sporulation protein FNV58_04020 ENOG4105E39 Enoyl-CoA hydratase FNV58_04055 ENOG4105E0A ABC, transporter FNV58_04060 ENOG4105EHG Permease protein FNV58_04070 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_04075 ENOG4105WQI isochorismatase FNV58_04095 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FNV58_04150 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV58_04190 ENOG4105EW9 transcriptional regulator AsnC family FNV58_04205 ENOG4107S5I aldo keto reductase FNV58_04245 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FNV58_04260 ENOG4105CWX Alpha-1,2-mannosidase FNV58_04265 ENOG4107SET aldo keto reductase FNV58_04275 ENOG4105XPP Protein of unknown function (DUF1275) FNV58_04280 ENOG4106NZI LysR family Transcriptional regulator FNV58_04285 ENOG4105EHZ conserved protein UCP016719 FNV58_04290 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FNV58_04300 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FNV58_04305 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FNV58_04320 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FNV58_04340 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FNV58_04355 ENOG4105EW6 flavin reductase domain protein, FMN-binding FNV58_04365 ENOG4105NTD Inherit from COG: Hydrolase FNV58_04370 ENOG4105E39 Enoyl-CoA hydratase FNV58_04380 ENOG4105C5I Dehydrogenase FNV58_04405 ENOG4105CHR reductase FNV58_04430 ENOG4105CS1 NAD(P)H quinone oxidoreductase FNV58_04440 ENOG4105KVH Transcriptional regulator FNV58_04455 ENOG41082JN Transcriptional regulator FNV58_04475 ENOG4105CC9 acyl-Coa dehydrogenase FNV58_04480 ENOG4105D2B acyl-CoA dehydrogenase FNV58_04490 ENOG4105DYW oxidoreductase FNV58_04495 ENOG4107YPT transcriptional regulator FNV58_04500 ENOG4105C1G acyl-Coa dehydrogenase FNV58_04510 ENOG4106YT9 Enoyl-CoA hydratase FNV58_04515 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_04525 ENOG4107SET aldo keto reductase FNV58_04530 ENOG4105CY0 Metallo-Beta-Lactamase FNV58_04555 ENOG4108UHU Aldolase FNV58_04565 ENOG4105CXK mandelate racemase muconate lactonizing FNV58_04585 ENOG4105DRS transport system, permease FNV58_04590 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FNV58_04600 ENOG4105EX0 alpha-galactosidase FNV58_04605 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FNV58_04625 ENOG4107QWG 2-Nitropropane dioxygenase FNV58_04665 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) FNV58_04675 ENOG4105R1U AraC Family Transcriptional Regulator FNV58_04680 ENOG4105EU0 Major facilitator Superfamily FNV58_04710 ENOG4105C26 Dehydrogenase FNV58_04730 ENOG4105D7V transposase FNV58_04740 ENOG4105ETE Transcriptional regulator (LacI family FNV58_04755 ENOG4105I1K ABC transporter FNV58_04870 ENOG4107QN2 dihydrolipoyl dehydrogenase FNV58_04890 ENOG4108ZHJ Organic hydroperoxide resistance protein FNV58_04930 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FNV58_04960 ENOG4105C0R drug resistance transporter emrb qaca subfamily FNV58_05000 ENOG4105EX0 alpha-galactosidase FNV58_05020 ENOG4105C6F GntR Family Transcriptional Regulator FNV58_05035 ENOG4105DRS transport system, permease FNV58_05055 ENOG4105CPQ Dehydrogenase FNV58_05060 ENOG4105CHR reductase FNV58_05065 ENOG4108UHU Aldolase FNV58_05080 ENOG4105ERH Fumarylacetoacetate hydrolase FNV58_05100 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FNV58_05140 ENOG4107U9B transcriptional regulator FNV58_05150 ENOG4105D7K pfkb domain protein FNV58_05155 ENOG4108UHU Aldolase FNV58_05160 ENOG4105CHR reductase FNV58_05165 ENOG4105CPQ Dehydrogenase FNV58_05180 ENOG4105DIA mandelate racemase muconate lactonizing FNV58_05185 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FNV58_05190 ENOG4105C2J ABC transporter FNV58_05205 ENOG4108PC0 lipolytic protein G-D-S-L family FNV58_05220 ENOG4105DSG hydrolase family 43 FNV58_05240 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FNV58_05255 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FNV58_05270 ENOG4105CJQ hydrolase, family 31 FNV58_05305 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FNV58_05315 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FNV58_05320 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FNV58_05335 ENOG4105E1F short-chain dehydrogenase reductase FNV58_05340 ENOG4108R85 Short chain dehydrogenase FNV58_05345 ENOG4105FDP GntR family transcriptional regulator FNV58_05365 ENOG4105E2D ec 3.2.1.52 FNV58_05370 ENOG4105D7V transposase FNV58_05375 ENOG4107QWR cellulase (EC 3.2.1.4) FNV58_05430 ENOG4105ESN nucleotide-binding protein FNV58_05440 ENOG4108PA7 Methyltransferase FNV58_05480 ENOG4106UDK Cellulose-binding, family II FNV58_05535 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FNV58_05540 ENOG4105CHR reductase FNV58_05550 ENOG4108ZHJ Organic hydroperoxide resistance protein FNV58_05590 ENOG4105CHU acetyl-coa acetyltransferase FNV58_05635 ENOG4107RSM transcriptional regulator FNV58_05650 ENOG4105CHR reductase FNV58_05675 ENOG4107S9F NmrA family FNV58_05685 ENOG4105C54 Major Facilitator superfamily FNV58_05690 ENOG4105EXC Acyl-transferase FNV58_05730 ENOG4105ETS cytosine purines uracil thiamine allantoin FNV58_05765 ENOG4105E2A Dehydrogenase FNV58_05775 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_05790 ENOG4105F0H myo-inositol catabolism protein FNV58_05800 ENOG4107QP6 Xylose isomerase domain protein TIM barrel FNV58_05825 ENOG4105JQZ Methyltransferase FNV58_05855 ENOG4105DFW ABC transporter FNV58_05865 ENOG4105DFW ABC transporter FNV58_05870 ENOG4105C2J ABC transporter FNV58_05875 ENOG4107RNG ABC transporter FNV58_05885 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FNV58_05890 ENOG4108K8U Glycerol operon regulatory protein FNV58_05920 ENOG4107YCR Transcriptional regulator, ARSR family FNV58_05930 ENOG4107R33 ppx gppa phosphatase FNV58_05940 ENOG4105ETE Transcriptional regulator (LacI family FNV58_05960 ENOG4105I1K ABC transporter FNV58_05985 ENOG4106A3M Cytochrome p-450 FNV58_06060 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FNV58_06065 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FNV58_06150 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FNV58_06160 ENOG4105DQ4 alcohol dehydrogenase FNV58_06190 ENOG4107RTD sua5 ycio yrdc ywlc family protein FNV58_06200 ENOG4105CFG Acts as a chaperone (By similarity) FNV58_06205 ENOG410827T Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FNV58_06220 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FNV58_06235 ENOG4107HP6 Transcriptional regulator FNV58_06240 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase FNV58_06245 ENOG4105C6Z Gluconate FNV58_06250 ENOG4105EQX glucarate dehydratase FNV58_06265 ENOG4105C19 ABC transporter FNV58_06270 ENOG4105BZU Histidine kinase FNV58_06275 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_06280 ENOG4105J7D transcriptional regulator FNV58_06285 ENOG4105CHR reductase FNV58_06295 ENOG4108KPJ rna polymerase sigma factor FNV58_06305 ENOG4108ME1 Peptidase M55 D-aminopeptidase FNV58_06335 ENOG4105D2S major facilitator superfamily FNV58_06350 ENOG4105JSC dimethylmenaquinone methyltransferase FNV58_06360 ENOG4108QBF Transcriptional regulator FNV58_06380 ENOG4107AQZ Membrane FNV58_06395 ENOG4105C0R drug resistance transporter emrb qaca subfamily FNV58_06460 ENOG4105D7V transposase FNV58_06555 ENOG4105E2R ROK family FNV58_06635 ENOG4105NAE bifunctional deaminase-reductase domain protein FNV58_06655 ENOG4105BZU Histidine kinase FNV58_06660 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_06705 ENOG4108V1U phospholipid-binding protein FNV58_06720 ENOG4105CHR reductase FNV58_06725 ENOG4107YCY Transcriptional regulator FNV58_06730 ENOG4105E39 Enoyl-CoA hydratase FNV58_06735 ENOG4105D2B acyl-CoA dehydrogenase FNV58_06740 ENOG4105CC9 acyl-Coa dehydrogenase FNV58_06745 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_06755 ENOG4105CGU Enoyl-CoA hydratase FNV58_06760 ENOG4105CHU acetyl-coa acetyltransferase FNV58_06765 ENOG4105C1G acyl-Coa dehydrogenase FNV58_06770 ENOG4105CHR reductase FNV58_06785 ENOG4105E39 Enoyl-CoA hydratase FNV58_06790 ENOG4105E39 Enoyl-CoA hydratase FNV58_06810 ENOG4108IV0 ABC, transporter FNV58_06815 ENOG4105C0Z ABC transporter FNV58_06840 ENOG4105CC9 acyl-Coa dehydrogenase FNV58_06850 ENOG4105D2B acyl-CoA dehydrogenase FNV58_06855 ENOG4105EBR Carboxylesterase FNV58_06860 ENOG4105E39 Enoyl-CoA hydratase FNV58_06875 ENOG4105CHU acetyl-coa acetyltransferase FNV58_06880 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_06900 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FNV58_06915 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_06925 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_06935 ENOG4105E39 Enoyl-CoA hydratase FNV58_06945 ENOG4108RZE Tetr family transcriptional regulator FNV58_06950 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FNV58_06985 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FNV58_06990 ENOG4105C26 Dehydrogenase FNV58_07005 ENOG4105CHR reductase FNV58_07015 ENOG4105DVW rieske (2Fe-2S) FNV58_07025 ENOG4105CI2 imidazolone-5-propionate hydrolase FNV58_07035 ENOG4105CC9 acyl-Coa dehydrogenase FNV58_07055 ENOG4105C1G acyl-Coa dehydrogenase FNV58_07060 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_07075 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase FNV58_07100 ENOG4108RZE Tetr family transcriptional regulator FNV58_07105 ENOG4105BZU Histidine kinase FNV58_07110 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_07130 ENOG4105EQ0 Major Facilitator superfamily FNV58_07180 ENOG4105DNP FAD linked oxidase domain protein FNV58_07195 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) FNV58_07205 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) FNV58_07210 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FNV58_07240 ENOG4107R39 (ABC) transporter FNV58_07340 ENOG4105E8G Major facilitator Superfamily FNV58_07365 ENOG4107VIJ nudix hydrolase FNV58_07380 ENOG4105D7V transposase FNV58_07395 ENOG4105CVR type I restriction-modification system FNV58_07450 ENOG4105ZXU NLP P60 protein FNV58_07495 ENOG4108EHY type IV secretion system FNV58_07530 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FNV58_07570 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FNV58_07585 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FNV58_07630 ENOG4107R7I amino acid FNV58_07640 ENOG4105CPF Cell wall formation (By similarity) FNV58_07660 ENOG4105DFU Cell wall formation (By similarity) FNV58_07730 ENOG4105K78 MarR family Transcriptional regulator FNV58_07795 ENOG4105C3K feS assembly ATPase SufC FNV58_07850 ENOG4105C0W non-ribosomal peptide synthetase FNV58_07995 ENOG4107SVN transposase FNV58_08055 ENOG4105CRK lysyL-tRNA synthetase FNV58_08270 ENOG4105DMQ Methyltransferase FNV58_08400 ENOG4105D5G Transposase FNV58_08410 ENOG4105FDF Could be involved in DNA repair (By similarity) FNV58_08450 ENOG4105F9F transposase FNV58_08530 ENOG4105VEQ Cold shock protein FNV58_08580 ENOG4105F5W AtP-binding protein FNV58_08585 ENOG4106IJN integrase catalytic domain-containing protein FNV58_08625 ENOG4105ETE Transcriptional regulator (LacI family FNV58_08630 ENOG4105EGE secreted protein FNV58_08645 ENOG4105EX0 alpha-galactosidase FNV58_08650 ENOG4105I1K ABC transporter FNV58_08655 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FNV58_08665 ENOG4105E2R ROK family FNV58_08680 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FNV58_08740 ENOG4105FDF Could be involved in DNA repair (By similarity) FNV58_08755 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FNV58_08780 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FNV58_08805 ENOG4107T8T UPF0173 metal-dependent hydrolase FNV58_08850 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FNV58_08855 ENOG4105CHR reductase FNV58_09120 ENOG410836F Transposase FNV58_09295 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FNV58_09305 ENOG4105KNA -acetyltransferase FNV58_09325 ENOG4107TRG DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) FNV58_09335 ENOG4105F9F transposase FNV58_09410 ENOG4105DQ6 Transposase FNV58_09445 ENOG4107SVN transposase FNV58_09460 ENOG4105CVR type I restriction-modification system FNV58_09520 ENOG4105BZP glycoside hydrolase 15-related FNV58_09545 ENOG4105CAY ferredoxin--nadp reductase FNV58_09565 ENOG4105EYF MMPL domain protein FNV58_09570 ENOG4105FQP Beta-lactamase FNV58_09580 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_09590 ENOG4105D7V transposase FNV58_09595 ENOG4108RS6 transposase FNV58_09620 ENOG4105VMP Transcriptional regulator FNV58_09685 ENOG4108RWI nicotinamidase FNV58_09695 ENOG4105D5G Transposase FNV58_09730 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FNV58_09770 ENOG4108YZ9 Urea amidohydrolase subunit gamma FNV58_09785 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) FNV58_09790 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FNV58_09800 ENOG4105VU5 Resolvase domain-containing protein FNV58_09820 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FNV58_09835 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein FNV58_09875 ENOG4107QQG Dehydrogenase FNV58_09885 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FNV58_09890 ENOG4108Z6Z Transcriptional regulator FNV58_09895 ENOG4105EMU Dehydrogenase FNV58_09915 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FNV58_09965 ENOG4105Q33 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency FNV58_10100 ENOG4105EFZ amidohydrolase FNV58_10150 ENOG4105C0D helicase FNV58_10205 ENOG4108YYH Nadph-dependent fmn reductase FNV58_10290 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FNV58_10345 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FNV58_10350 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FNV58_10355 ENOG4107QRA Extracellular solute-binding protein, family 5 FNV58_10385 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FNV58_10390 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FNV58_10395 ENOG4108XHQ (2Fe-2S)-binding domain protein FNV58_10420 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FNV58_10510 ENOG4105CIR epoxide hydrolase FNV58_10515 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FNV58_10520 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FNV58_10550 ENOG4105BZU Histidine kinase FNV58_10610 ENOG4105IDI abc transporter atp-binding protein FNV58_10630 ENOG4105E7U AraC family transcriptional regulator FNV58_10640 ENOG4105CPC Aldo Keto reductase FNV58_10645 ENOG4108M0I Transcriptional regulator FNV58_10660 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FNV58_10665 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FNV58_10670 ENOG410841Q phosphoesterase PA-phosphatase related protein FNV58_10685 ENOG4107S5I aldo keto reductase FNV58_10695 ENOG4105C26 Dehydrogenase FNV58_10700 ENOG4105CHP RNA polymerase FNV58_10715 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FNV58_10730 ENOG4105FBW Monooxygenase FNV58_10745 ENOG4105CGD Nad-dependent epimerase dehydratase FNV58_10750 ENOG4105CVP deoxyribo-dipyrimidine photolyase FNV58_10830 ENOG4107QTZ amino acid FNV58_10835 ENOG4105DKQ ROK family FNV58_10860 ENOG4105EX0 alpha-galactosidase FNV58_10865 ENOG4105C5X domain protein FNV58_10885 ENOG4105CPC Aldo Keto reductase FNV58_10915 ENOG4105CAQ asparagine synthetase FNV58_10920 ENOG4105CBC glutamate synthase FNV58_10925 ENOG4105CEU Arginine dihydrolase FNV58_10930 ENOG4105D5Q Arginine ornithine antiporter FNV58_10940 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FNV58_10995 ENOG4107SM8 Adenylate Guanylate cyclase FNV58_11035 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_11070 ENOG4105X7H acyl-CoA dehydrogenase FNV58_11095 ENOG4108JQ6 ABC transporter FNV58_11100 ENOG4108EU3 peptide transport system, permease FNV58_11110 ENOG4105DEF Extracellular solute-binding protein, family 5 FNV58_11135 ENOG4107QI1 Mate efflux family protein FNV58_11140 ENOG4105ETE Transcriptional regulator (LacI family FNV58_11145 ENOG4107RJ5 oxidoreductase FNV58_11155 ENOG4105FDP GntR family transcriptional regulator FNV58_11160 ENOG4105C26 Dehydrogenase FNV58_11165 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FNV58_11170 ENOG4105DH8 myo-inositol catabolism FNV58_11180 ENOG4105EDK PfkB domain protein FNV58_11190 ENOG4105CNN ABC, transporter FNV58_11195 ENOG4105C2J ABC transporter FNV58_11210 ENOG4105C7K acetolactate synthase FNV58_11215 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FNV58_11220 ENOG4107R5W Monooxygenase FNV58_11225 ENOG4105DVW rieske (2Fe-2S) FNV58_11230 ENOG4105CHR reductase FNV58_11240 ENOG4105C1G acyl-Coa dehydrogenase FNV58_11245 ENOG4105CC9 acyl-Coa dehydrogenase FNV58_11255 ENOG4105CC9 acyl-Coa dehydrogenase FNV58_11260 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FNV58_11270 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_11275 ENOG4105CYC Transferase FNV58_11305 ENOG4107YCY Transcriptional regulator FNV58_11310 ENOG4105CHR reductase FNV58_11320 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FNV58_11325 ENOG4105C1G acyl-Coa dehydrogenase FNV58_11385 ENOG41067SE Tetr family transcriptional regulator FNV58_11395 ENOG4105D3W isochorismatase FNV58_11405 ENOG4107YPT transcriptional regulator FNV58_11470 ENOG4105CT3 Monooxygenase FNV58_11495 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FNV58_11500 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FNV58_11505 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FNV58_11515 ENOG4105C0X amino acid FNV58_11565 ENOG4108JA1 polyketide synthase FNV58_11575 ENOG4105ENX hydrolase FNV58_11625 ENOG4108J5G 6-phosphogluconate dehydrogenase FNV58_11645 ENOG4105E66 phosphoriboisomerase A FNV58_11650 ENOG4105CMT Dihydroxyacetone kinase FNV58_11655 ENOG4108UTZ Dihydroxyacetone kinase FNV58_11670 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FNV58_11700 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FNV58_11705 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FNV58_11750 ENOG4105I82 acetyl xylan esterase FNV58_11765 ENOG4105FDP GntR family transcriptional regulator FNV58_11775 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV58_11780 ENOG4105CG3 alpha amylase, catalytic region FNV58_11785 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FNV58_11795 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FNV58_11800 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FNV58_11840 ENOG4105ERH Fumarylacetoacetate hydrolase FNV58_11855 ENOG4105CHP RNA polymerase FNV58_11865 ENOG4105GRZ Ycii-related protein FNV58_11875 ENOG4108UYE Lactoylglutathione lyase FNV58_11880 ENOG4105CHR reductase FNV58_11890 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FNV58_11900 ENOG4105DZ1 carboxypeptidase FNV58_11905 ENOG4108VJY integral membrane protein FNV58_11910 ENOG4107JC6 Membrane FNV58_11915 ENOG4105CSV Glutaminase FNV58_11920 ENOG4108IJ0 Aspartate ammonia-lyase FNV58_11940 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FNV58_11950 ENOG4105KJJ Uncharacterized ACR, COG1993 FNV58_11955 ENOG41083YR Protein CrcB homolog FNV58_11980 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FNV58_11990 ENOG4105ETE Transcriptional regulator (LacI family FNV58_12010 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) FNV58_12025 ENOG4108KC1 acyl-Coa dehydrogenase FNV58_12035 ENOG4105EDW glycosyl transferase, family 39 FNV58_12075 ENOG4107RRZ synthase FNV58_12090 ENOG4105QVC MOSC domain-containing protein FNV58_12110 ENOG4105MVE transcriptional regulator FNV58_12135 ENOG4107R34 abc transporter permease protein FNV58_12140 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FNV58_12165 ENOG4105DKQ ROK family FNV58_12170 ENOG4105CF1 Alkylated DNA repair protein FNV58_12175 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) FNV58_12200 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FNV58_12205 ENOG4105E98 transcriptional regulator DeoR family FNV58_12210 ENOG4105CWX Alpha-1,2-mannosidase FNV58_12215 ENOG4108IJ8 ABC transporter FNV58_12220 ENOG4105E90 ABC transporter FNV58_12240 ENOG4105GWZ Roadblock lc7 family protein FNV58_12260 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 FNV58_12270 ENOG4107P5I polyketide synthase FNV58_12280 ENOG4107RCI amp-dependent synthetase and ligase FNV58_12290 ENOG4108YIQ Alpha beta hydrolase FNV58_12295 ENOG4108MRH transcriptional regulatory protein FNV58_12300 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FNV58_12305 ENOG4105D7T ABC transporter FNV58_12310 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FNV58_12340 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FNV58_12345 ENOG4105C4M (Ubiquinol oxidase) subunit I FNV58_12400 ENOG4105BZP glycoside hydrolase 15-related FNV58_12420 ENOG4106UW1 Major Facilitator superfamily FNV58_12445 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_12450 ENOG4105BZU Histidine kinase FNV58_12465 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FNV58_12470 ENOG4107PP3 Acetylornithine deacetylase FNV58_12475 ENOG4105I1F Resistance protein FNV58_12505 ENOG4105I1K ABC transporter FNV58_12520 ENOG4105EX0 alpha-galactosidase FNV58_12530 ENOG41060NJ transcriptional regulator FNV58_12550 ENOG4105C10 Electron transfer flavoprotein FNV58_12575 ENOG4105PSQ Acyl-transferase FNV58_12605 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FNV58_12690 ENOG4105YVS arsR family transcriptional regulator FNV58_12695 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FNV58_12710 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_12715 ENOG4105BZU Histidine kinase FNV58_12730 ENOG4105DBE peroxidase FNV58_12735 ENOG410650H (LipO)protein FNV58_12745 ENOG4105CRK lysyL-tRNA synthetase FNV58_12755 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FNV58_12785 ENOG4105KKX ATPase associated with various cellular activities aaa_5 FNV58_12790 ENOG4105DEG Vwa containing coxe family protein FNV58_12820 ENOG4105EBM Alpha Beta Hydrolase Fold protein FNV58_12825 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FNV58_12830 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FNV58_12840 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FNV58_12855 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FNV58_12895 ENOG4105C7W Xanthine dehydrogenase FNV58_12900 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding FNV58_12905 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit FNV58_12915 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FNV58_12950 ENOG4108RQS Two component transcriptional regulator (Winged helix family FNV58_12985 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FNV58_13025 ENOG4105V9V Short-chain dehydrogenase reductase Sdr FNV58_13045 ENOG4105CHR reductase FNV58_13050 ENOG4107Z6X Transcriptional regulator FNV58_13075 ENOG4107S5I aldo keto reductase FNV58_13080 ENOG4105EMU Dehydrogenase FNV58_13100 ENOG4105C1J atp-dependent rna helicase FNV58_13110 ENOG4107ZED Uncharacterised protein family UPF0047 FNV58_13115 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FNV58_13120 ENOG4105E2Y ABC, transporter FNV58_13130 ENOG4105H3G oxidoreductase FNV58_13140 ENOG4105BZ1 (ABC) transporter FNV58_13150 ENOG4105CK2 sodium dicarboxylate symporter FNV58_13170 ENOG4105BZ1 (ABC) transporter FNV58_13195 ENOG4105C29 acyl-CoA thioesterase FNV58_13205 ENOG4105GWZ Roadblock lc7 family protein FNV58_13235 ENOG4105BZU Histidine kinase FNV58_13275 ENOG4105C0D helicase FNV58_13295 ENOG4105C93 Xylose Isomerase FNV58_13305 ENOG4105E2R ROK family FNV58_13310 ENOG4105C85 amino acid FNV58_13315 ENOG4107SCA Formamidase (EC 3.5.1.49) FNV58_13325 ENOG4107RR1 TRANSCRIPTIONal FNV58_13330 ENOG4105C26 Dehydrogenase FNV58_13370 ENOG4108UGD Serine Threonine protein kinase FNV58_13395 ENOG4105D2B acyl-CoA dehydrogenase FNV58_13400 ENOG4105D2B acyl-CoA dehydrogenase FNV58_13405 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FNV58_13415 ENOG4105C3M thioredoxin reductase FNV58_13420 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) FNV58_13430 ENOG4105C26 Dehydrogenase FNV58_13445 ENOG41065KQ synthase FNV58_13450 ENOG4106A3M Cytochrome p-450 FNV58_13460 ENOG4105C1G acyl-Coa dehydrogenase FNV58_13470 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FNV58_13480 ENOG4105F1K Glutamine amidotransferase FNV58_13485 ENOG4105CTQ phosphohexokinase FNV58_13500 ENOG4105D9P serine threonine protein kinase FNV58_13505 ENOG4108HRK Histidine kinase FNV58_13520 ENOG4108NEV two component transcriptional regulator, LytTR family FNV58_13530 ENOG4105CIK Amidinotransferase FNV58_13535 ENOG4105C8Y Acetylornithine aminotransferase FNV58_13545 ENOG410600Z Regulatory protein MarR FNV58_13555 ENOG4105KVH Transcriptional regulator FNV58_13580 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FNV58_13610 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) FNV58_13620 ENOG4105CQM Urea amidohydrolase subunit alpha FNV58_13625 ENOG4105KI2 Urea amidohydrolase subunit beta FNV58_13630 ENOG4108YZ9 Urea amidohydrolase subunit gamma FNV58_13680 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FNV58_13685 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FNV58_13690 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FNV58_13730 ENOG4105FBW Monooxygenase FNV58_13735 ENOG4108R6G acetyltransferase FNV58_13780 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase FNV58_13790 ENOG4105C83 adenylosuccinate lyase FNV58_13795 ENOG4108VCA G U mismatch-specific DNA glycosylase FNV58_13815 ENOG4105BZU Histidine kinase FNV58_13820 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_13825 ENOG4105DKQ ROK family FNV58_13830 ENOG4105FDP GntR family transcriptional regulator FNV58_13835 ENOG4108KPJ rna polymerase sigma factor FNV58_13840 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 FNV58_13850 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FNV58_13885 ENOG4107RSM transcriptional regulator FNV58_13900 ENOG4105EYH Exonuclease FNV58_13905 ENOG4107RFY SbcCD D subunit FNV58_13910 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FNV58_13930 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_13940 ENOG4105X7H acyl-CoA dehydrogenase FNV58_13955 ENOG4105K4P CoA-binding domain protein FNV58_13965 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FNV58_13995 ENOG4105CSR polyphosphate kinase 2 FNV58_14025 ENOG4108UW5 maltose o-acetyltransferase FNV58_14030 ENOG4108Z0R Transferase FNV58_14045 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FNV58_14060 ENOG4105ETE Transcriptional regulator (LacI family FNV58_14100 ENOG4105CVK Glutamate decarboxylase FNV58_14125 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FNV58_14140 ENOG4105CHU acetyl-coa acetyltransferase FNV58_14145 ENOG4107YPT transcriptional regulator FNV58_14165 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FNV58_14190 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FNV58_14210 ENOG4105DEN Luciferase family FNV58_14220 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FNV58_14225 ENOG4105EP9 oxidoreductase FNV58_14245 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FNV58_14250 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FNV58_14255 ENOG4105CHR reductase FNV58_14285 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FNV58_14295 ENOG4105EJQ L-serine dehydratase FNV58_14300 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FNV58_14305 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FNV58_14345 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FNV58_14365 ENOG4108IJ7 Glycine betaine FNV58_14370 ENOG4105C26 Dehydrogenase FNV58_14390 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FNV58_14400 ENOG4105DVW rieske (2Fe-2S) FNV58_14405 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase FNV58_14415 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FNV58_14455 ENOG4108Q5Y Membrane FNV58_14460 ENOG4105CSW GntR family transcriptional regulator FNV58_14500 ENOG4105JAB phenazine biosynthesis protein, phzf family FNV58_14530 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FNV58_14540 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FNV58_14560 ENOG4108UW8 fha domain-containing protein FNV58_14615 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FNV58_14630 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FNV58_14635 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FNV58_14645 ENOG4105E09 nadh pyrophosphatase FNV58_14650 ENOG4108UQS dipeptidase FNV58_14660 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FNV58_14665 ENOG4105BZU Histidine kinase FNV58_14670 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FNV58_14675 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FNV58_14695 ENOG4105GWZ Roadblock lc7 family protein FNV58_14745 ENOG4107RGD Major Facilitator superfamily FNV58_14750 ENOG4105CFM UPF0317 protein FNV58_14755 ENOG4105E7W lamb ycsf family protein FNV58_14760 ENOG4105P4J Allophanate hydrolase, subunit 1 FNV58_14765 ENOG4107R7A Allophanate hydrolase subunit 2 FNV58_14770 ENOG41090WU lipolytic protein G-D-S-L family FNV58_14775 ENOG4108MJN Glycosyl Transferase FNV58_14790 ENOG4105JXB ankyrin repeat-containing protein FNV58_14805 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FNV58_14820 ENOG4105DEU major facilitator superfamily FNV58_14825 ENOG4105Q70 FNV58_14835 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FNV58_14845 ENOG4105EW9 transcriptional regulator AsnC family FNV58_14870 ENOG4105C1G acyl-Coa dehydrogenase FNV58_14880 ENOG4107Z3H Transcriptional regulator, TetR family FNV58_14900 ENOG4107S03 uridine kinase FNV58_14925 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FNV58_14930 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase FNV58_14935 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FNV58_14940 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FNV58_14955 ENOG4105E2R ROK family FNV58_14960 ENOG4106UW1 Major Facilitator superfamily FNV58_14975 ENOG4105C2W permease FNV58_15020 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 FNV58_15025 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FNV58_15035 ENOG4105F38 ABC transporter, permease FNV58_15045 ENOG4108TZY GntR Family Transcriptional Regulator FNV58_15055 ENOG4105CUB amino acid FNV58_15075 ENOG4105DKT Transcriptional regulator FNV58_15080 ENOG4105DJV ribulose-phosphate 3-epimerase FNV58_15090 ENOG4107QN2 dihydrolipoyl dehydrogenase FNV58_15110 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FNV58_15125 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FNV58_15140 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FNV58_15150 ENOG4105SKN orotidine 5''-phosphate decarboxylase FNV58_15155 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FNV58_15160 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FNV58_15165 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FNV58_15175 ENOG4105CD3 dihydroorotase FNV58_15180 ENOG4105CXT aspartate transcarbamylase FNV58_15185 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FNV58_15195 ENOG410803B Involved in the transcription termination process (By similarity) FNV58_15200 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FNV58_15205 ENOG4105DC7 peptidase M24 FNV58_15215 ENOG4105D49 3-dehydroquinate synthase FNV58_15220 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FNV58_15225 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FNV58_15230 ENOG4105E2X shikimate dehydrogenase FNV58_15235 ENOG4105HHA aminodeoxychorismate lyase FNV58_15245 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FNV58_15250 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FNV58_15270 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FNV58_15285 ENOG4105CJ1 ABC, transporter FNV58_15295 ENOG4105BZU Histidine kinase FNV58_15300 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_15305 ENOG4105CUT histidyl-tRNA synthetase FNV58_15315 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) FNV58_15320 ENOG4105C99 atpase involved in dna repair FNV58_15325 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FNV58_15335 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FNV58_15340 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FNV58_15345 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FNV58_15355 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FNV58_15360 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FNV58_15365 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FNV58_15370 ENOG4105CDY transcriptional regulatory protein FNV58_15375 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FNV58_15380 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FNV58_15400 ENOG4105E2K Glycosyl transferase (Group 1 FNV58_15410 ENOG4108VTU Cdp-alcohol phosphatidyltransferase FNV58_15435 ENOG4105C22 threonyL-tRNA synthetase FNV58_15450 ENOG4108IRC dna polymerase iii FNV58_15470 ENOG4105EKC FNV58_15480 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FNV58_15485 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FNV58_15505 ENOG4105KF0 sporulation and cell division protein, SsgA FNV58_15530 ENOG4105F0I Aminotransferase FNV58_15595 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FNV58_15600 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FNV58_15615 ENOG4105D01 (LipO)protein FNV58_15620 ENOG4108UMI ABC transporter, permease FNV58_15625 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FNV58_15660 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_15665 ENOG4105C57 major facilitator superfamily FNV58_15670 ENOG4105RJZ Transcriptional regulator FNV58_15680 ENOG4105CH7 arginosuccinase FNV58_15685 ENOG4105CDH Citrulline--aspartate ligase FNV58_15705 ENOG4105BZU Histidine kinase FNV58_15710 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV58_15740 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FNV58_15745 ENOG4105C8Y Acetylornithine aminotransferase FNV58_15750 ENOG4105CAS nag kinase FNV58_15755 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FNV58_15760 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FNV58_15780 ENOG4105VUF Transcriptional regulator FNV58_15815 ENOG4105T38 integral membrane protein FNV58_15825 ENOG4105F32 YngK protein FNV58_15840 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FNV58_15855 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FNV58_15860 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FNV58_15865 ENOG4105BZU Histidine kinase FNV58_15870 ENOG4108RWN rrna methyltransferase FNV58_15875 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FNV58_15880 ENOG41084BS 50S ribosomal protein L35 FNV58_15885 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FNV58_15910 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FNV58_15940 ENOG4105C26 Dehydrogenase FNV58_15945 ENOG4105C5F glutamine synthetase FNV58_15955 ENOG4108Z86 Glutamine amidotransferase FNV58_15995 ENOG4108HQS Glycine betaine FNV58_16000 ENOG4108IJ7 Glycine betaine FNV58_16005 ENOG4105HFS 5'-3' exonuclease FNV58_16035 ENOG4105D3G Pseudouridine synthase FNV58_16065 ENOG4105MKU Transcriptional regulator FNV58_16105 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FNV58_16110 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FNV58_16140 ENOG4108V1T peptidylprolyl cis-trans isomerase FNV58_16145 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) FNV58_16155 ENOG4105ETE Transcriptional regulator (LacI family FNV58_16160 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) FNV58_16165 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) FNV58_16175 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) FNV58_16180 ENOG4105E5F proteasome FNV58_16185 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) FNV58_16220 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_16230 ENOG4108J59 Extracellular solute-binding protein, family 5 FNV58_16235 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FNV58_16240 ENOG4105C3R Methionine synthase FNV58_16245 ENOG4108K8U Glycerol operon regulatory protein FNV58_16250 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FNV58_16255 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FNV58_16265 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FNV58_16275 ENOG4105C2J ABC transporter FNV58_16285 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FNV58_16290 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) FNV58_16295 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FNV58_16300 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FNV58_16305 ENOG4105JXH GntR family transcriptional regulator FNV58_16330 ENOG4105C8N cysteinyl-tRNA synthetase FNV58_16350 ENOG4105D7N magnesium and cobalt transport protein CorA FNV58_16360 ENOG4105DYW oxidoreductase FNV58_16365 ENOG4105CPC Aldo Keto reductase FNV58_16395 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FNV58_16410 ENOG4105CD8 aminopeptidase N FNV58_16415 ENOG4105K5B UPF0225 protein FNV58_16420 ENOG4105C6F GntR Family Transcriptional Regulator FNV58_16425 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FNV58_16430 ENOG4105C6Z Gluconate FNV58_16435 ENOG4105CHR reductase FNV58_16440 ENOG4105CPQ Dehydrogenase FNV58_16465 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein FNV58_16475 ENOG4105PTV Nudix Hydrolase FNV58_16480 ENOG4105VG5 Membrane FNV58_16500 ENOG4105C1G acyl-Coa dehydrogenase FNV58_16505 ENOG4108IG5 Transcriptional regulator FNV58_16510 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_16520 ENOG4105EHZ conserved protein UCP016719 FNV58_16540 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FNV58_16545 ENOG4108Z4X TRANSCRIPTIONal FNV58_16565 ENOG4105C1G acyl-Coa dehydrogenase FNV58_16575 ENOG4108ZHR arsR family transcriptional regulator FNV58_16580 ENOG4107Y9U Membrane FNV58_16605 ENOG4105D4T Citrate transporter FNV58_16610 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FNV58_16615 ENOG4108SGK Tetr family transcriptional regulator FNV58_16625 ENOG4105F1J Homogentisate 1,2-dioxygenase FNV58_16630 ENOG4105FDP GntR family transcriptional regulator FNV58_16660 ENOG4105RNG membrane FNV58_16665 ENOG4105K6V RNA polymerase FNV58_16685 ENOG4105D9P serine threonine protein kinase FNV58_16690 ENOG4108TCJ secreted hydrolase FNV58_16710 ENOG4107BJW polysaccharide deacetylase FNV58_16735 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FNV58_16775 ENOG4108Z2K Cupin 2, conserved barrel domain protein FNV58_16780 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FNV58_16785 ENOG4105C0B DNA polymerase III (alpha subunit) FNV58_16800 ENOG4106NMR serine protease FNV58_16810 ENOG4105CPU Monooxygenase FNV58_16815 ENOG4105CPU Monooxygenase FNV58_16820 ENOG4105CDA abc transporter atp-binding protein FNV58_16835 ENOG4105EAB amino acid AbC transporter FNV58_16845 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FNV58_16850 ENOG4105C1G acyl-Coa dehydrogenase FNV58_16855 ENOG4105C57 major facilitator superfamily FNV58_16865 ENOG410841Q phosphoesterase PA-phosphatase related protein FNV58_16875 ENOG4105BZ9 Cytochrome C oxidase, subunit I FNV58_16905 ENOG4105C2J ABC transporter FNV58_16910 ENOG4108IV0 ABC, transporter FNV58_16935 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FNV58_16945 ENOG4105CAT Cytidine monophosphate kinase FNV58_16985 ENOG410756H nucleotidyltransferase FNV58_16990 ENOG41065RQ ADP-ribosylation crystallin J1 FNV58_17000 ENOG4105FE9 pseudouridine synthase FNV58_17005 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FNV58_17010 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FNV58_17025 ENOG4105DCF alanine dehydrogenase FNV58_17035 ENOG4108YZ4 nudix hydrolase FNV58_17040 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FNV58_17045 ENOG4105BZP glycoside hydrolase 15-related FNV58_17070 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FNV58_17075 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FNV58_17095 ENOG4105E0A ABC, transporter FNV58_17100 ENOG4105TVJ transport system, permease FNV58_17105 ENOG4105DQ5 transport system permease protein FNV58_17110 ENOG4105DSU hydrolase FNV58_17150 ENOG4108VX5 3-methyladenine DNA glycosylase FNV58_17160 ENOG4108V1U phospholipid-binding protein FNV58_17180 ENOG4105DKW ABC transporter FNV58_17205 ENOG4105CAN Short-chain dehydrogenase reductase Sdr FNV58_17210 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FNV58_17220 ENOG4105IDI abc transporter atp-binding protein FNV58_17230 ENOG4105EAC phosphoserine phosphatase FNV58_17235 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FNV58_17250 ENOG4107YCY Transcriptional regulator FNV58_17260 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FNV58_17265 ENOG4105CHR reductase FNV58_17280 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FNV58_17300 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FNV58_17305 ENOG4107QN1 sodium solute FNV58_17320 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FNV58_17325 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F FNV58_17375 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FNV58_17390 ENOG4105BZP glycoside hydrolase 15-related FNV58_17440 ENOG4105C5H ABC transporter FNV58_17470 ENOG4107W7X Aldolase FNV58_17490 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FNV58_17495 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FNV58_17500 ENOG4105CTK cobaltochelatase, cobn subunit FNV58_17510 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FNV58_17515 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FNV58_17530 ENOG4105CIA precorrin-4 C(11)-methyltransferase FNV58_17540 ENOG4105E4R Precorrin-3B C17-methyltransferase FNV58_17545 ENOG41081F0 Precorrin-8x methylmutase FNV58_17550 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FNV58_17580 ENOG4105EAD ABC transporter FNV58_17585 ENOG4105CT1 (ABC) transporter FNV58_17590 ENOG4105C5R Aminotransferase FNV58_17595 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase FNV58_17600 ENOG4108JPW Aminotransferase FNV58_17605 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) FNV58_17610 ENOG4105EV8 ectoine hydroxylase FNV58_17615 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FNV58_17640 ENOG4107HP6 Transcriptional regulator FNV58_17650 ENOG4105CJN penicillin-binding protein FNV58_17655 ENOG4105C7N Xanthine uracil vitamin C permease FNV58_17660 ENOG4105NAF rna polymerase sigma factor FNV58_17675 ENOG4108J21 pectate lyase FNV58_17720 ENOG4108J20 pectate lyase FNV58_17725 ENOG4107TDE lipolytic protein G-D-S-L family FNV58_17730 ENOG4107T3P ABC, transporter FNV58_17735 ENOG4105E4I Glycoside hydrolase family 28 FNV58_17765 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FNV58_17770 ENOG4105DRR Transcriptional regulator, GntR family FNV58_17795 ENOG4105E9Z Nad-dependent epimerase dehydratase FNV58_17800 ENOG4105E98 transcriptional regulator DeoR family FNV58_17820 ENOG4105CPQ Dehydrogenase FNV58_17830 ENOG4105XEA Tetr family transcriptional regulator FNV58_17845 ENOG4107XBN GntR Family Transcriptional Regulator FNV58_17885 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FNV58_17900 ENOG4105EEM helicase FNV58_17915 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) FNV58_17920 ENOG4108RFG Tetr family transcriptional regulator FNV58_17925 ENOG410814C multidrug resistance protein FNV58_17940 ENOG4105VG1 fes assembly suf system protein FNV58_17945 ENOG4108UNV SUF system FeS assembly protein, NifU family FNV58_17950 ENOG4105C9B Cysteine desulfurase FNV58_17955 ENOG4105C3K feS assembly ATPase SufC FNV58_17965 ENOG4105JRK feS assembly protein SufD FNV58_17980 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FNV58_17985 ENOG4105CJ1 ABC, transporter FNV58_18010 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FNV58_18025 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FNV58_18040 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) FNV58_18045 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component FNV58_18050 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component FNV58_18060 ENOG4105CG3 alpha amylase, catalytic region FNV58_18065 ENOG4107T3P ABC, transporter FNV58_18070 ENOG4105U3E Transcriptional regulator FNV58_18075 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV58_18090 ENOG4107QP8 phosphohexose isomerase FNV58_18110 ENOG4105CP7 Triose-phosphate isomerase FNV58_18115 ENOG4105BZA Phosphoglycerate kinase FNV58_18120 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FNV58_18130 ENOG4105CIE May be required for sporulation (By similarity) FNV58_18135 ENOG4105CHW UPF0052 protein FNV58_18140 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FNV58_18145 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FNV58_18160 ENOG4105ETE Transcriptional regulator (LacI family FNV58_18170 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FNV58_18185 ENOG4107R0W ABC transporter FNV58_18190 ENOG4105E5Q amino acid AbC transporter FNV58_18200 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FNV58_18205 ENOG4105CSH Transporter FNV58_18230 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FNV58_18235 ENOG4105BZU Histidine kinase FNV58_18240 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FNV58_18245 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FNV58_18265 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) FNV58_18275 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV58_18280 ENOG4105D7N magnesium and cobalt transport protein CorA FNV58_18310 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FNV58_18315 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FNV58_18355 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FNV58_18380 ENOG4107QRT dEAD DEAH box helicase FNV58_18430 ENOG4105M03 Domain of unknown function (DUF955) FNV58_18495 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FNV58_18500 ENOG4105DRR Transcriptional regulator, GntR family FNV58_18515 ENOG4105D9G High-affinity FNV58_18545 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FNV58_18565 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV58_18570 ENOG4105CQ7 ATP-dependent helicase FNV58_18610 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) FNV58_18620 ENOG4105C32 Amino acid ABC transporter (Permease) FNV58_18625 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FNV58_18630 ENOG4105C0Z ABC transporter FNV58_18635 ENOG4108IV0 ABC, transporter FNV58_18670 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FNV58_18690 ENOG4108ZXC Two component transcriptional regulator, luxr family FNV58_18695 ENOG4105EHE chorismate mutase- prephenate dehydrogenase FNV58_18700 ENOG41063TF transcriptional regulator (AraC FNV58_18730 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FNV58_18735 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FNV58_18740 ENOG41060WC Enoyl-CoA hydratase FNV58_18755 ENOG4105EA8 2-Nitropropane dioxygenase FNV58_18765 ENOG4105F2C Acetyl-CoA acetyltransferase FNV58_18770 ENOG4108RZE Tetr family transcriptional regulator FNV58_18780 ENOG4105CC9 acyl-Coa dehydrogenase FNV58_18785 ENOG4105C1G acyl-Coa dehydrogenase FNV58_18790 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FNV58_18795 ENOG41090B9 response to stress FNV58_18800 ENOG4105MUA Resistance protein FNV58_18815 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV58_18830 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FNV58_18840 ENOG4105CBC glutamate synthase FNV58_18850 ENOG41065RQ ADP-ribosylation crystallin J1 FNV58_18870 ENOG4108RVA ribokinase FNV58_18875 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FNV58_18880 ENOG4105CI0 Citrate lyase FNV58_18885 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FNV58_18895 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FNV58_18900 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FNV58_18910 ENOG4105DK0 Indole-3-glycerol phosphate synthase FNV58_18935 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FNV58_18955 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FNV58_18960 ENOG4108176 endoribonuclease L-psp FNV58_18965 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FNV58_18970 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FNV58_18975 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FNV58_18980 ENOG4105CIH Imidazole acetol-phosphate transaminase FNV58_18985 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FNV58_19005 ENOG4108Z66 YbaK ebsC protein FNV58_19030 ENOG4105C0B DNA polymerase III (alpha subunit) FNV58_19090 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FNV58_19095 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FNV58_19105 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FNV58_19110 ENOG4107VQS DivIVA family FNV58_19120 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FNV58_19125 ENOG4105DFA alanine racemase domain protein FNV58_19130 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FNV58_19135 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FNV58_19150 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FNV58_19160 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FNV58_19165 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FNV58_19175 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FNV58_19180 ENOG4105CJN penicillin-binding protein FNV58_19190 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FNV58_19200 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FNV58_19220 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FNV58_19230 ENOG4105CDA abc transporter atp-binding protein FNV58_19240 ENOG4107Z3H Transcriptional regulator, TetR family FNV58_19250 ENOG4105EWK phytoene FNV58_19265 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FNV58_19295 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FNV58_19305 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FNV58_19315 ENOG4108UQY Iron-storage protein FNV58_19325 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase FNV58_19345 ENOG4105CTQ phosphohexokinase FNV58_19355 ENOG4105ENE Histidine kinase FNV58_19380 ENOG4105DKQ ROK family FNV58_19390 ENOG4105D0U Arsenite-activated ATPase (ArsA) FNV58_19430 ENOG4105UQX Mate efflux family protein FNV58_19475 ENOG4105C9B Cysteine desulfurase FNV58_19480 ENOG4108I0Q anthranilate phosphoribosyltransferase FNV58_19485 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FNV58_19490 ENOG4107EUI c reductase, iron-sulfur FNV58_19495 ENOG4107UDY cytochrome C FNV58_19500 ENOG4105CCU oxidase (Subunit III) FNV58_19515 ENOG4105MCD Part of cytochrome c oxidase, its function is FNV58_19520 ENOG4105BZ9 Cytochrome C oxidase, subunit I FNV58_19525 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) FNV58_19530 ENOG4105C3J Cysteine desulfurase FNV58_19560 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FNV58_19565 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_19590 ENOG4105DXX methyltransferase FNV58_19595 ENOG4105C0H protease FNV58_19605 ENOG4108YZT Adenosylcobinamide kinase FNV58_19615 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FNV58_19620 ENOG4105CRK lysyL-tRNA synthetase FNV58_19635 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FNV58_19640 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FNV58_19665 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FNV58_19695 ENOG4105I4A GCN5-related N-acetyltransferase FNV58_19715 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FNV58_19720 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FNV58_19740 ENOG4105C5F glutamine synthetase FNV58_19750 ENOG4105D0M Protease HtpX homolog FNV58_19780 ENOG4108222 arsenate reductase FNV58_19785 ENOG4106SPC secreted protein FNV58_19795 ENOG4107R5B glutamine synthetase FNV58_19800 ENOG4107NHD transcriptional regulator FNV58_19815 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_19845 ENOG41060BG Tetr family transcriptional regulator FNV58_19885 ENOG4105EG2 ABC transporter, permease FNV58_19890 ENOG4105CG3 alpha amylase, catalytic region FNV58_19895 ENOG4105ETE Transcriptional regulator (LacI family FNV58_19905 ENOG4107RSM transcriptional regulator FNV58_19910 ENOG4105FDR Membrane FNV58_19915 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FNV58_19920 ENOG4105FBN Acid phosphatase FNV58_19960 ENOG4105C5F glutamine synthetase FNV58_19965 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FNV58_19970 ENOG41081JD Transcriptional regulator FNV58_19990 ENOG4105C4K Nad synthetase FNV58_19995 ENOG4105F27 Major Facilitator FNV58_20010 ENOG4105C57 major facilitator superfamily FNV58_20015 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FNV58_20035 ENOG4107XZ0 Peptidase M50 FNV58_20095 ENOG410650H (LipO)protein FNV58_20100 ENOG4105DBE peroxidase FNV58_20110 ENOG4106A0S FNV58_20115 ENOG4105C8T Leucyl-tRNA synthetase FNV58_20125 ENOG4105CIK Amidinotransferase FNV58_20140 ENOG4105C2C drug resistance transporter, Bcr CflA FNV58_20165 ENOG4105C19 ABC transporter FNV58_20170 ENOG4105CPC Aldo Keto reductase FNV58_20180 ENOG4108VGI doxx family FNV58_20195 ENOG4105GCF PGAM FNV58_20205 ENOG4105CHR reductase FNV58_20220 ENOG4106NZI LysR family Transcriptional regulator FNV58_20245 ENOG4105CY3 ABC transporter, permease FNV58_20330 ENOG4105E7U AraC family transcriptional regulator FNV58_20350 ENOG4107XFJ UPF0246 protein FNV58_20355 ENOG4108UHU Aldolase FNV58_20360 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FNV58_20370 ENOG4105CVJ phosphoglycerate mutase FNV58_20380 ENOG4105EGD dinuclear metal center protein, YbgI family FNV58_20395 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FNV58_20410 ENOG4108M15 ABC transporter FNV58_20420 ENOG4105BZU Histidine kinase FNV58_20475 ENOG4105DYW oxidoreductase FNV58_20500 ENOG4107QVI Methyltransferase, type 11 FNV58_20510 ENOG4108SGK Tetr family transcriptional regulator FNV58_20545 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase FNV58_20570 ENOG4105BZ1 (ABC) transporter FNV58_20590 ENOG4105XPP Protein of unknown function (DUF1275) FNV58_20615 ENOG4105F2C Acetyl-CoA acetyltransferase FNV58_20620 ENOG4106A3M Cytochrome p-450 FNV58_20635 ENOG4105CSH Transporter FNV58_20720 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FNV58_20725 ENOG4105D3W isochorismatase FNV58_20730 ENOG41080V3 Major Facilitator superfamily FNV58_20750 ENOG4105KVH Transcriptional regulator FNV58_20855 ENOG4105BZ4 penicillin-binding protein FNV58_20870 ENOG4105DAX Pfam:DUF2983 FNV58_20920 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FNV58_20925 ENOG4105EYW Ion transport protein FNV58_20950 ENOG4105CPC Aldo Keto reductase FNV58_20955 ENOG4105VUF Transcriptional regulator FNV58_20985 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FNV58_20990 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FNV58_21010 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FNV58_21020 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FNV58_21025 ENOG4108R86 Transcriptional regulator FNV58_21040 ENOG4106KE4 Dehydrogenase FNV58_21045 ENOG4105DUM transcriptional regulator, lysR family FNV58_21050 ENOG4105NGS secreted protein FNV58_21055 ENOG4105EXN Sulfate transport protein CysZ FNV58_21075 ENOG4108ZHJ Organic hydroperoxide resistance protein FNV58_21080 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FNV58_21110 ENOG4105DFW ABC transporter FNV58_21120 ENOG4108HWW ABC transporter FNV58_21125 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FNV58_21130 ENOG4105CIH Imidazole acetol-phosphate transaminase FNV58_21165 ENOG4108ZHJ Organic hydroperoxide resistance protein FNV58_21195 ENOG4108YIQ Alpha beta hydrolase FNV58_21240 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase FNV58_21245 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FNV58_21250 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FNV58_21260 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FNV58_21265 ENOG41069M3 Transcriptional regulator FNV58_21290 ENOG41073B4 coagulation factor 5 8 type domain-containing protein FNV58_21365 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_21370 ENOG4105D8K carboxyl transferase FNV58_21375 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FNV58_21380 ENOG4105DFF Rod shape-determining protein mreb FNV58_21425 ENOG4105C32 Amino acid ABC transporter (Permease) FNV58_21435 ENOG4108IV0 ABC, transporter FNV58_21440 ENOG4105C0Z ABC transporter FNV58_21445 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_21495 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FNV58_21500 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FNV58_21510 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FNV58_21520 ENOG4107GZ4 SanA protein FNV58_21585 ENOG4107QZF nitrite reductase NADPH large subunit FNV58_21595 ENOG4108XFH Transcriptional regulator FNV58_21600 ENOG4105CHR reductase FNV58_21615 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV58_21635 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FNV58_21640 ENOG4105E2R ROK family FNV58_21705 ENOG4105CPC Aldo Keto reductase FNV58_21715 ENOG4108SGK Tetr family transcriptional regulator FNV58_21720 ENOG4105E1F short-chain dehydrogenase reductase FNV58_21725 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FNV58_21730 ENOG4105DSE periplasmic solute binding protein FNV58_21735 ENOG4105FDK ABC transporter FNV58_21750 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FNV58_21755 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) FNV58_21765 ENOG4108762 serine threonine protein kinase FNV58_21805 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FNV58_21810 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_21815 ENOG4105BZU Histidine kinase FNV58_21820 ENOG4105CJ1 ABC, transporter FNV58_21835 ENOG4105JXH GntR family transcriptional regulator FNV58_21840 ENOG4105DEF Extracellular solute-binding protein, family 5 FNV58_21850 ENOG4105C3U ABC transporter FNV58_21855 ENOG4108JQ7 (ABC) transporter FNV58_21860 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FNV58_21875 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FNV58_21885 ENOG4105D4Y metalloprotease FNV58_21895 ENOG4105CS2 ec 3.2.1.21 FNV58_21940 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FNV58_21960 ENOG4105MSB protein, conserved in bacteria FNV58_21970 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FNV58_21995 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FNV58_22000 ENOG4107YU2 histidine triad (hIT) protein FNV58_22005 ENOG4107RE3 peptidase, S41 FNV58_22025 ENOG4107QWG 2-Nitropropane dioxygenase FNV58_22030 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FNV58_22035 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FNV58_22060 ENOG4105BZU Histidine kinase FNV58_22065 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FNV58_22075 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FNV58_22080 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FNV58_22140 ENOG4105KQC Competence protein FNV58_22145 ENOG4105EPR degv family FNV58_22155 ENOG4105C8T Leucyl-tRNA synthetase FNV58_22170 ENOG4107QIZ NADH dehydrogenase FNV58_22210 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FNV58_22225 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FNV58_22230 ENOG4105D0M Protease HtpX homolog FNV58_22245 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FNV58_22255 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FNV58_22265 ENOG4105CG5 Glycosyl transferase (Group 1 FNV58_22270 ENOG4107SJB teichoic acid biosynthesis FNV58_22275 ENOG4107SJB teichoic acid biosynthesis FNV58_22290 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FNV58_22295 ENOG4105K46 50S ribosomal protein l27 FNV58_22300 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FNV58_22305 ENOG4105C03 ribonuclease FNV58_22360 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FNV58_22365 ENOG41082YX Transcriptional regulator, arsr family FNV58_22370 ENOG41089UC methyltransferase, type 11 FNV58_22380 ENOG4105C57 major facilitator superfamily FNV58_22415 ENOG4105CNI cell division protein FtsW FNV58_22420 ENOG4105CJN penicillin-binding protein FNV58_22435 ENOG4105DFF Rod shape-determining protein mreb FNV58_22440 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FNV58_22450 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FNV58_22455 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FNV58_22465 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FNV58_22470 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FNV58_22475 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FNV58_22480 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FNV58_22505 ENOG4108TGC Acyltransferase FNV58_22535 ENOG4105C85 amino acid FNV58_22540 ENOG4108UGD Serine Threonine protein kinase FNV58_22555 ENOG4105E2R ROK family FNV58_22565 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FNV58_22570 ENOG4105E2Y ABC, transporter FNV58_22575 ENOG4105CPU Monooxygenase FNV58_22585 ENOG4105C85 amino acid FNV58_22590 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FNV58_22595 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FNV58_22605 ENOG4105MC2 DSBA oxidoreductase FNV58_22640 ENOG4108UYE Lactoylglutathione lyase FNV58_22720 ENOG4107SCK Monooxygenase FNV58_22745 ENOG4105F9F transposase FNV58_22750 ENOG4108JJB ABC transporter FNV58_22775 ENOG4105D8X mechanosensitive ion channel FNV58_22805 ENOG4105BZ7 extracellular solute-binding protein family 1 FNV58_22810 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component FNV58_22815 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FNV58_22820 ENOG4105F8D glycoside hydrolase family 4 FNV58_22835 ENOG4105CT1 (ABC) transporter FNV58_22865 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FNV58_22870 ENOG4108Z18 K06886 hemoglobin FNV58_22915 ENOG4108QV3 biosynthesis protein FNV58_22935 ENOG4105D3Q Sugar transferase FNV58_22990 ENOG4105C30 Nad-dependent epimerase dehydratase FNV58_23050 ENOG4105VHU single-stranded DNA-binding protein FNV58_23110 ENOG4105S2J secreted protein FNV58_23150 ENOG4105C26 Dehydrogenase FNV58_23155 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FNV58_23160 ENOG4105DH8 myo-inositol catabolism FNV58_23170 ENOG4105EDK PfkB domain protein FNV58_23175 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FNV58_23195 ENOG4107R13 MMPL domain protein FNV58_23225 ENOG4105C7H Helicase, RecD TraA family FNV58_23245 ENOG4105C2J ABC transporter FNV58_23250 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FNV58_23255 ENOG4108RVA ribokinase FNV58_23260 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FNV58_23285 ENOG4105ETE Transcriptional regulator (LacI family FNV58_23290 ENOG410645S MarR family Transcriptional regulator FNV58_23300 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FNV58_23305 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FNV58_23310 ENOG4105D17 glycoside hydrolase, family 3 domain protein FNV58_23350 ENOG4105EDW glycosyl transferase, family 39 FNV58_23355 ENOG4108K8S endonuclease I FNV58_23360 ENOG4105C7K acetolactate synthase FNV58_23370 ENOG4105CK7 Sodium proline symporter FNV58_23380 ENOG4108XFF FNV58_23390 ENOG4105C29 acyl-CoA thioesterase FNV58_23405 ENOG4107QX3 carboxylase FNV58_23415 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FNV58_23420 ENOG4105C1G acyl-Coa dehydrogenase FNV58_23455 ENOG4105DY8 decarboxylase FNV58_23460 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) FNV58_23470 ENOG4105DUU IucA IucC family protein FNV58_23475 ENOG4105E2D ec 3.2.1.52 FNV58_23495 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FNV58_23520 ENOG4105ECQ AraC Family Transcriptional Regulator FNV58_23525 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FNV58_23545 ENOG4105ETE Transcriptional regulator (LacI family FNV58_23560 ENOG4105DRS transport system, permease FNV58_23575 ENOG4108NNZ chitinase FNV58_23580 ENOG410804D Sensor Signal Transduction Histidine Kinase FNV58_23585 ENOG4108RQS Two component transcriptional regulator (Winged helix family FNV58_23610 ENOG4105CVJ phosphoglycerate mutase FNV58_23655 ENOG4105BZU Histidine kinase FNV58_23660 ENOG4105DEN Luciferase family FNV58_23680 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FNV58_23685 ENOG4105DV0 amidase (EC 3.5.1.4 FNV58_23725 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_23740 ENOG4105DFM M18 family aminopeptidase FNV58_23760 ENOG4105J5T Amp-dependent synthetase and ligase FNV58_23770 ENOG4108M1A Chitin-binding protein FNV58_23800 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) FNV58_23825 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FNV58_23835 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FNV58_23845 ENOG4105MWK D-amino acid dehydrogenase, small subunit FNV58_23850 ENOG4105FDP GntR family transcriptional regulator FNV58_23865 ENOG4105D9R oxidoreductase FNV58_23870 ENOG41090KN UPF0303 protein FNV58_23880 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FNV58_23890 ENOG4107YPT transcriptional regulator FNV58_23900 ENOG4108U4N (sortase) family FNV58_23910 ENOG4105CVA phosphate FNV58_23985 ENOG41067TZ transcriptional regulator, MarR family FNV58_24010 ENOG4107QNK )-transporter FNV58_24015 ENOG4106BRA Membrane FNV58_24030 ENOG4105CJ1 ABC, transporter FNV58_24045 ENOG4105BZ4 penicillin-binding protein FNV58_24080 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FNV58_24090 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FNV58_24095 ENOG4105CI1 PTS System FNV58_24120 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein FNV58_24165 ENOG4105C85 amino acid FNV58_24180 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FNV58_24190 ENOG4108RWI nicotinamidase FNV58_24200 ENOG4107G87 m6 family metalloprotease domain protein FNV58_24220 ENOG4105KF0 sporulation and cell division protein, SsgA FNV58_24225 ENOG4105CQB FAD linked oxidase domain protein FNV58_24235 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FNV58_24245 ENOG4105E90 ABC transporter FNV58_24265 ENOG41063PX domain protein FNV58_24270 ENOG4105DTQ mandelate racemase muconate lactonizing FNV58_24280 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FNV58_24300 ENOG4105CUB amino acid FNV58_24350 ENOG4105E2D ec 3.2.1.52 FNV58_24360 ENOG4105D56 permease protein FNV58_24365 ENOG4107T3P ABC, transporter FNV58_24375 ENOG4108UJU UPF0301 protein FNV58_24380 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FNV58_24385 ENOG4108426 dNA-binding protein FNV58_24395 ENOG4105EEM helicase FNV58_24425 ENOG4105DQQ Major facilitator superfamily MFS_1 FNV58_24445 ENOG4105EMY transcriptional regulator FNV58_24460 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FNV58_24465 ENOG4105I1K ABC transporter FNV58_24470 ENOG4105CJQ hydrolase, family 31 FNV58_24475 ENOG4105ETE Transcriptional regulator (LacI family FNV58_24480 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FNV58_24500 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FNV58_24505 ENOG4105CN1 protease FNV58_24515 ENOG4105CAK Cell division ATP-binding protein ftsE FNV58_24530 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) FNV58_24535 ENOG4108QVN serine threonine protein kinase FNV58_24540 ENOG4108UGD Serine Threonine protein kinase FNV58_24565 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component FNV58_24570 ENOG4107SJB teichoic acid biosynthesis FNV58_24575 ENOG4107SJB teichoic acid biosynthesis FNV58_24595 ENOG4108ZHJ Organic hydroperoxide resistance protein FNV58_24600 ENOG4105K56 Transcriptional regulator FNV58_24615 ENOG4105K64 Glycosyl transferase, family 2 FNV58_24640 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_24665 ENOG4105EY8 ABC transporter FNV58_24670 ENOG4105CG5 Glycosyl transferase (Group 1 FNV58_24675 ENOG4107SJB teichoic acid biosynthesis FNV58_24685 ENOG4105C7I Dehydrogenase FNV58_24710 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FNV58_24720 ENOG4105T0Z Conserved Protein FNV58_24725 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_24730 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea FNV58_24740 ENOG4105G3P Lipoprotein lpqB FNV58_24745 ENOG4105BZU Histidine kinase FNV58_24750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV58_24755 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FNV58_24770 ENOG4108WQ6 secreted protein FNV58_24775 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FNV58_24820 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FNV58_24830 ENOG4105EIP mannose-6-phosphate isomerase FNV58_24840 ENOG4105W49 UPF0434 protein FNV58_24845 ENOG4107QKV phosphomannomutase FNV58_24870 ENOG4106BQ7 Glycosyl Transferase FNV58_24875 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FNV58_24890 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase FNV58_24895 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) FNV58_24905 ENOG4108S0S Nucleotidyl transferase FNV58_24920 ENOG4108KGH TRANSCRIPTIONal FNV58_24925 ENOG4108KGH TRANSCRIPTIONal FNV58_24945 ENOG4108KGH TRANSCRIPTIONal FNV58_24955 ENOG4105PAD Hydrolase FNV58_24970 ENOG4105C6Y Udp-glucose 6-dehydrogenase FNV58_25015 ENOG41065SU Two-component system sensor kinase FNV58_25020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV58_25025 ENOG4105DUX Transporter FNV58_25050 ENOG4108Z4X TRANSCRIPTIONal FNV58_25080 ENOG41082AN stage II sporulation protein FNV58_25085 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FNV58_25095 ENOG4105CI2 imidazolone-5-propionate hydrolase FNV58_25110 ENOG4105CGP Urocanate hydratase FNV58_25155 ENOG4105C84 Histidine ammonia-lyase FNV58_25160 ENOG4108IJ8 ABC transporter FNV58_25165 ENOG4105E90 ABC transporter FNV58_25170 ENOG4105E90 ABC transporter FNV58_25180 ENOG41060NJ transcriptional regulator FNV58_25195 ENOG4108V9Q carbonic anhydrase FNV58_25215 ENOG4105CHU acetyl-coa acetyltransferase FNV58_25260 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FNV58_25265 ENOG4107RBB ABC transporter, permease FNV58_25270 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FNV58_25275 ENOG4105CEP NADH dehydrogenase FNV58_25295 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FNV58_25305 ENOG4105MS9 Resuscitation-promoting factor FNV58_25310 ENOG4106A3M Cytochrome p-450 FNV58_25375 ENOG4105XYF acetyltransferase FNV58_25430 ENOG4105EJ2 Transcriptional regulator FNV58_25445 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FNV58_25450 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FNV58_25455 ENOG4105C0R drug resistance transporter emrb qaca subfamily FNV58_25465 ENOG4107QN1 sodium solute FNV58_25495 ENOG4108ZGX Histidine kinase FNV58_25510 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FNV58_25515 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FNV58_25520 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FNV58_25525 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FNV58_25535 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FNV58_25545 ENOG41067SE Tetr family transcriptional regulator FNV58_25555 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FNV58_25560 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FNV58_25565 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_25575 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FNV58_25620 ENOG4105C5H ABC transporter FNV58_25630 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FNV58_25635 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FNV58_25645 ENOG4105F8V Hydrolase, tatD family FNV58_25675 ENOG4108ZFD Antibiotic biosynthesis monooxygenase FNV58_25680 ENOG4107Y2X deaminase FNV58_25685 ENOG4105CJN penicillin-binding protein FNV58_25710 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) FNV58_25720 ENOG4108JJB ABC transporter FNV58_25725 ENOG4105K56 Transcriptional regulator FNV58_25730 ENOG4108ZHJ Organic hydroperoxide resistance protein FNV58_25755 ENOG4105CPC Aldo Keto reductase FNV58_25760 ENOG4108RF4 Tetr family transcriptional regulator FNV58_25765 ENOG4105EYF MMPL domain protein FNV58_25785 ENOG4108R85 Short chain dehydrogenase FNV58_25790 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FNV58_25795 ENOG4105F95 Monooxygenase FNV58_25805 ENOG4105CGK Exodeoxyribonuclease III FNV58_25825 ENOG4108Z9I -acetyltransferase FNV58_25830 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FNV58_25835 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FNV58_25845 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FNV58_25850 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase FNV58_25860 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) FNV58_25880 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) FNV58_25890 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FNV58_25925 ENOG4105DM4 PTS System FNV58_25930 ENOG4105DE4 1-phosphofructokinase FNV58_25935 ENOG4105E98 transcriptional regulator DeoR family FNV58_25965 ENOG4108Z7F N-acetyltransferase FNV58_25970 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FNV58_26000 ENOG4107HP6 Transcriptional regulator FNV58_26005 ENOG4105C57 major facilitator superfamily FNV58_26060 ENOG4107QN1 sodium solute FNV58_26080 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_26085 ENOG4105BZU Histidine kinase FNV58_26145 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_26175 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_26180 ENOG4108ZGX Histidine kinase FNV58_26205 ENOG4105DNP FAD linked oxidase domain protein FNV58_26225 ENOG4105FDP GntR family transcriptional regulator FNV58_26250 ENOG4108V06 Glutathione peroxidase FNV58_26265 ENOG4105DZ1 carboxypeptidase FNV58_26320 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) FNV58_26340 ENOG4105KVH Transcriptional regulator FNV58_26350 ENOG4105EMU Dehydrogenase FNV58_26355 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FNV58_26360 ENOG41088PD hydrolase FNV58_26430 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_26450 ENOG4108762 serine threonine protein kinase FNV58_26460 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FNV58_26470 ENOG4105D2B acyl-CoA dehydrogenase FNV58_26480 ENOG4108I0C methyltransferase FNV58_26485 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FNV58_26530 ENOG4105CMV Succinyl-CoA synthetase subunit beta FNV58_26535 ENOG4105CGU Enoyl-CoA hydratase FNV58_26540 ENOG4105MXW flavin reductase domain protein, FMN-binding FNV58_26545 ENOG4105D2S major facilitator superfamily FNV58_26560 ENOG4105CC9 acyl-Coa dehydrogenase FNV58_26585 ENOG4105D2B acyl-CoA dehydrogenase FNV58_26590 ENOG4105CC9 acyl-Coa dehydrogenase FNV58_26600 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_26605 ENOG4107EG8 signal transduction protein with EFhand domain FNV58_26610 ENOG41082AN stage II sporulation protein FNV58_26615 ENOG4105K6V RNA polymerase FNV58_26665 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FNV58_26675 ENOG4108SU4 UPF0309 protein FNV58_26700 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FNV58_26710 ENOG4105CGU Enoyl-CoA hydratase FNV58_26715 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_26730 ENOG4107QX3 carboxylase FNV58_26765 ENOG4105BZ1 (ABC) transporter FNV58_26770 ENOG4105CQB FAD linked oxidase domain protein FNV58_26795 ENOG4106A3M Cytochrome p-450 FNV58_26805 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FNV58_26825 ENOG4108Z6Z Transcriptional regulator FNV58_26835 ENOG4105CPC Aldo Keto reductase FNV58_26850 ENOG4105XMC MarR family Transcriptional regulator FNV58_26860 ENOG4105C7N Xanthine uracil vitamin C permease FNV58_26870 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FNV58_26900 ENOG4108N0W Major Facilitator superfamily FNV58_26910 ENOG4108UIH futalosine nucleosidase FNV58_26915 ENOG4105E63 Pfam:DUF178 FNV58_26920 ENOG4105VEQ Cold shock protein FNV58_26945 ENOG4105CFI type iii restriction protein res subunit FNV58_26960 ENOG4105EEM helicase FNV58_26965 ENOG4106N3A copper homeostasis protein cutc FNV58_26985 ENOG4105KNA -acetyltransferase FNV58_27000 ENOG4105QEK Transcriptional regulator FNV58_27005 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FNV58_27010 ENOG4105C5Y PTS System FNV58_27045 ENOG4108Z6Z Transcriptional regulator FNV58_27050 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FNV58_27055 ENOG4105EBR Carboxylesterase FNV58_27065 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FNV58_27070 ENOG4105VEQ Cold shock protein FNV58_27085 ENOG4105C3Q Glycosyl transferase, family 2 FNV58_27115 ENOG4105CE4 GlcNAc 6-P deacetylase FNV58_27120 ENOG4105DE4 1-phosphofructokinase FNV58_27135 ENOG4105BZU Histidine kinase FNV58_27140 ENOG4105MXW flavin reductase domain protein, FMN-binding FNV58_27155 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) FNV58_27180 ENOG4105CD8 aminopeptidase N FNV58_27260 ENOG4108IJ9 (ABC) transporter FNV58_27280 ENOG4105C2N RNA methyltransferase TrmH family group 3 FNV58_27285 ENOG4105C8N cysteinyl-tRNA synthetase FNV58_27290 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FNV58_27295 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FNV58_27300 ENOG4108VJ1 Transcriptional regulator (CarD family FNV58_27320 ENOG4105BZU Histidine kinase FNV58_27360 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FNV58_27380 ENOG4105QNJ serralysin (EC 3.4.24.40) FNV58_27385 ENOG4108YZJ Pfam:DUF2596 FNV58_27390 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FNV58_27430 ENOG4105ECP epimerase FNV58_27435 ENOG4108KPJ rna polymerase sigma factor FNV58_27445 ENOG4105CHR reductase FNV58_27455 ENOG4108XFH Transcriptional regulator FNV58_27460 ENOG4105CPQ Dehydrogenase FNV58_27485 ENOG4105FDP GntR family transcriptional regulator FNV58_27495 ENOG4105FDP GntR family transcriptional regulator FNV58_27505 ENOG4105HHS UPF0256 protein FNV58_27520 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FNV58_27525 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FNV58_27530 ENOG41090R7 Ferric uptake FNV58_27535 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands FNV58_27570 ENOG4105PKJ carbohydrate binding FNV58_27575 ENOG4105KHC sulfurtransferase FNV58_27605 ENOG4107NHD transcriptional regulator FNV58_27610 ENOG4105ETE Transcriptional regulator (LacI family FNV58_27615 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap FNV58_27620 ENOG4105C0H protease FNV58_27635 ENOG4105ETX regulatoR FNV58_27645 ENOG4105ETX regulatoR FNV58_27650 ENOG4105BZ1 (ABC) transporter FNV58_27655 ENOG4105CGH 5'-nucleotidase FNV58_27660 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FNV58_27675 ENOG4105CJ1 ABC, transporter FNV58_27690 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FNV58_27695 ENOG4105CZV ABC transporter FNV58_27710 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FNV58_27740 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FNV58_27745 ENOG4105CJ3 phosphate transporter FNV58_27755 ENOG4105VPX protein, conserved in bacteria FNV58_27770 ENOG4105DNP FAD linked oxidase domain protein FNV58_27775 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FNV58_27780 ENOG4105E4C Lytic transglycosylase catalytic FNV58_27900 ENOG4105ESP cell wall surface anchor family protein FNV58_27920 ENOG4105D5U fad dependent oxidoreductase FNV58_27925 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FNV58_27935 ENOG4105CPC Aldo Keto reductase FNV58_27970 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) FNV58_27990 ENOG4105C1J atp-dependent rna helicase FNV58_28030 ENOG4105CQ7 ATP-dependent helicase FNV58_28050 ENOG4108TAC FNV58_28065 ENOG4105CXB phosphoribosylaminoimidazole synthetase FNV58_28085 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii FNV58_28090 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I FNV58_28095 ENOG410839H phosphoribosylformylglycinamidine synthase FNV58_28125 ENOG4105BZU Histidine kinase FNV58_28140 ENOG4105C8V SAICAR synthetase FNV58_28155 ENOG4105C12 Phosphoribosylglycinamide synthetase FNV58_28200 ENOG4105I6B RNA polymerase FNV58_28240 ENOG4105D7A ATP-binding protein FNV58_28255 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FNV58_28270 ENOG4108Z6B deaminase FNV58_28285 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein FNV58_28290 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FNV58_28295 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FNV58_28310 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FNV58_28325 ENOG410905P Pyridoxamine 5-phosphate FNV58_28335 ENOG4105C57 major facilitator superfamily FNV58_28340 ENOG4105EDW glycosyl transferase, family 39 FNV58_28350 ENOG4105BZU Histidine kinase FNV58_28355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV58_28365 ENOG4105KAC Antibiotic biosynthesis monooxygenase FNV58_28425 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_28430 ENOG4105NAF rna polymerase sigma factor FNV58_28445 ENOG4105C1G acyl-Coa dehydrogenase FNV58_28455 ENOG4105X7H acyl-CoA dehydrogenase FNV58_28515 ENOG4105C0H protease FNV58_28535 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FNV58_28555 ENOG4107T6F Xaa-Pro aminopeptidase FNV58_28570 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase FNV58_28590 ENOG4105EYF MMPL domain protein FNV58_28595 ENOG4105BZU Histidine kinase FNV58_28630 ENOG4105DBE peroxidase FNV58_28635 ENOG4105CQC Prephenate dehydratase FNV58_28640 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FNV58_28645 ENOG410667J hydrolase FNV58_28675 ENOG4105DA5 (ABC) transporter FNV58_28685 ENOG4107SWG transcriptional regulator MERR family FNV58_28690 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) FNV58_28700 ENOG410667J hydrolase FNV58_28710 ENOG4108JJ9 ABC, transporter FNV58_28715 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FNV58_28720 ENOG4105C4M (Ubiquinol oxidase) subunit I FNV58_28725 ENOG4105CIH Imidazole acetol-phosphate transaminase FNV58_28730 ENOG4107P2S Transcriptional regulator FNV58_28735 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FNV58_28750 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FNV58_28775 ENOG4106048 Cupin 2, conserved barrel domain protein FNV58_28780 ENOG41082T9 Membrane FNV58_28785 ENOG4105KJF protein tyrosine phosphatase FNV58_28790 ENOG4105C28 cystathionine FNV58_28825 ENOG4105F27 Major Facilitator FNV58_28845 ENOG4105CDU Replicative dna helicase FNV58_28860 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FNV58_28865 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FNV58_28870 ENOG4107YH6 single-stranded DNA-binding protein FNV58_28875 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) FNV58_28900 ENOG4108JQC penicillin-binding protein 1A FNV58_28925 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FNV58_28955 ENOG4105C3M thioredoxin reductase FNV58_28960 ENOG4105K63 Thioredoxin FNV58_28975 ENOG4107QJE Chromosome Partitioning Protein FNV58_28980 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FNV58_28990 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FNV58_28995 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FNV58_29000 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FNV58_29010 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FNV58_29020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FNV58_29025 ENOG4108J5G 6-phosphogluconate dehydrogenase FNV58_29030 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FNV58_29035 ENOG4105K7N UPF0232 protein FNV58_29040 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FNV58_29045 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FNV58_29080 ENOG4108UGD Serine Threonine protein kinase FNV58_29110 ENOG4105ZJT Cell division protein CrgA FNV58_29120 ENOG4108U4N (sortase) family FNV58_29135 ENOG4108U4N (sortase) family FNV58_29140 ENOG4108RN7 integral membrane protein FNV58_29155 ENOG4105CJN penicillin-binding protein FNV58_29170 ENOG4105HZM Fha domain containing protein FNV58_29175 ENOG4105TV9 FHA Domain-Containing protein FNV58_29195 ENOG41064MX Tetr family transcriptional regulator FNV58_29200 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV58_29215 ENOG4108JIK carboxylase FNV58_29230 ENOG4105CZS beta-ketoacyl synthase FNV58_29275 ENOG4105D8K carboxyl transferase FNV58_29315 ENOG4105KVH Transcriptional regulator FNV58_29320 ENOG4105C0R drug resistance transporter emrb qaca subfamily FNV58_29340 ENOG4105DNP FAD linked oxidase domain protein FNV58_29360 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FNV58_29400 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase FNV58_29410 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FNV58_29415 ENOG4108IG5 Transcriptional regulator FNV58_29435 ENOG4107QSN dihydrolipoamide acetyltransferase FNV58_29440 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FNV58_29470 ENOG4107QPV Serine Threonine protein kinase FNV58_29500 ENOG4105CPP Dehydrogenase, E1 component FNV58_29505 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 FNV58_29560 ENOG4105DFM M18 family aminopeptidase FNV58_29565 ENOG4105CSU acyl-Coa dehydrogenase FNV58_29575 ENOG4105EUB pirin domain protein FNV58_29590 ENOG4105C9M aspartyl-trna synthetase FNV58_29620 ENOG4108J20 pectate lyase FNV58_29630 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FNV58_29650 ENOG4105EM2 membrane FNV58_29660 ENOG4105F2Z 3-oxoadipate enol-lactonase FNV58_29665 ENOG4107SQD Transcriptional regulator, GntR family FNV58_29695 ENOG4105BZU Histidine kinase FNV58_29700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV58_29715 ENOG4107T3P ABC, transporter FNV58_29720 ENOG4105CH2 amidohydrolase FNV58_29735 ENOG4105EUZ Beta-lactamase domain protein FNV58_29745 ENOG4105BZ4 penicillin-binding protein FNV58_29785 ENOG4105VEQ Cold shock protein FNV58_29820 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FNV58_29870 ENOG4105D9P serine threonine protein kinase FNV58_29885 ENOG4105JVQ RNA Polymerase FNV58_29895 ENOG4108HCJ Hydrolase FNV58_29945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV58_29950 ENOG4105BZU Histidine kinase FNV58_29960 ENOG4105EYF MMPL domain protein FNV58_29965 ENOG4105BZU Histidine kinase FNV58_29970 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_29990 ENOG41082SX arsR family transcriptional regulator FNV58_29995 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FNV58_30010 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FNV58_30080 ENOG4105CSR polyphosphate kinase 2 FNV58_30085 ENOG4105BZP glycoside hydrolase 15-related FNV58_30090 ENOG4105C57 major facilitator superfamily FNV58_30120 ENOG4105E2A Dehydrogenase FNV58_30160 ENOG4108JQC penicillin-binding protein 1A FNV58_30180 ENOG4108762 serine threonine protein kinase FNV58_30235 ENOG4106F60 Histidine kinase FNV58_30240 ENOG4105ETX regulatoR FNV58_30310 ENOG4105DHP deoxycytidine triphosphate deaminase FNV58_30335 ENOG4105DF6 Fe-S oxidoreductase FNV58_30345 ENOG4105CFG Acts as a chaperone (By similarity) FNV58_30350 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FNV58_30355 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FNV58_30360 ENOG4105KNI merR family transcriptional Regulator FNV58_30370 ENOG4105DFW ABC transporter FNV58_30440 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FNV58_30475 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FNV58_30490 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FNV58_30495 ENOG4107RCW fructose-bisphosphate aldolase FNV58_30515 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FNV58_30540 ENOG4108ZGX Histidine kinase FNV58_30545 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_30550 ENOG4105BZU Histidine kinase FNV58_30555 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_30570 ENOG4105DIM ABC transporter FNV58_30575 ENOG4105CIG ABC transporter FNV58_30590 ENOG4105CPD ethanolamine ammonia-lyase FNV58_30595 ENOG4107FQ9 ethanolamine ammonia-lyase FNV58_30605 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FNV58_30610 ENOG4105CGH 5'-nucleotidase FNV58_30620 ENOG4108WYP Transcriptional regulator FNV58_30625 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FNV58_30630 ENOG4108V4B ThiJ pfpI FNV58_30660 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FNV58_30665 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FNV58_30700 ENOG4105BZU Histidine kinase FNV58_30710 ENOG4105CFH Aspartokinase FNV58_30750 ENOG4105D17 glycoside hydrolase, family 3 domain protein FNV58_30825 ENOG4108IUX (ABC) transporter FNV58_30885 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FNV58_30935 ENOG4105BZ4 penicillin-binding protein FNV58_30975 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FNV58_30990 ENOG4105P8F nudix hydrolase FNV58_31005 ENOG4105D74 hydrolase FNV58_31015 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FNV58_31020 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FNV58_31025 ENOG4105CHH sulfate transporter FNV58_31085 ENOG4108I5C dEAD DEAH box helicase FNV58_31090 ENOG4105WN5 stage II sporulation protein FNV58_31095 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FNV58_31100 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for FNV58_31115 ENOG4108DT4 serine threonine protein kinase FNV58_31125 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FNV58_31130 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FNV58_31135 ENOG4105C6E dna polymerase iii FNV58_31150 ENOG4107T65 Integrase FNV58_31215 ENOG41062IR nudix hydrolase FNV58_31265 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV58_31275 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_31350 ENOG4105C2M dna polymerase I FNV58_31375 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FNV58_31380 ENOG4105KDC 50s ribosomal protein l28 FNV58_31385 ENOG4105W0E 50S ribosomal protein L33 FNV58_31390 ENOG4105NRA 50s ribosomal protein l31 type b FNV58_31400 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FNV58_31420 ENOG4105C26 Dehydrogenase FNV58_31440 ENOG4105CVK Glutamate decarboxylase FNV58_31450 ENOG4107TXC Transcriptional regulator FNV58_31455 ENOG41082VC UPF0145 protein FNV58_31470 ENOG4105F0N pyrophosphate phospho-hydrolase FNV58_31485 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FNV58_31490 ENOG4108UGV hypoxanthine phosphoribosyltransferase FNV58_31500 ENOG4105EUJ GTP cyclohydrolase i FNV58_31510 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FNV58_31530 ENOG4105CRK lysyL-tRNA synthetase FNV58_31555 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV58_31575 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_31580 ENOG4105I1F Resistance protein FNV58_31605 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FNV58_31610 ENOG4108IYU L-aspartate oxidase FNV58_31620 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FNV58_31660 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FNV58_31670 ENOG4105DR5 peptidase FNV58_31675 ENOG4108IG5 Transcriptional regulator FNV58_31690 ENOG4108FKE two-component system sensor kinase FNV58_31695 ENOG4108PYU two-component system response regulator FNV58_31700 ENOG41075QH Lipoprotein CseA FNV58_31705 ENOG4105NAF rna polymerase sigma factor FNV58_31720 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) FNV58_31735 ENOG4108JWX FNV58_31740 ENOG4107R33 ppx gppa phosphatase FNV58_31745 ENOG4105EY0 Xylose isomerase domain protein TIM barrel FNV58_31750 ENOG4105XEA Tetr family transcriptional regulator FNV58_31755 ENOG4105C01 Dihydroxy-acid dehydratase FNV58_31760 ENOG4108762 serine threonine protein kinase FNV58_31770 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein FNV58_31780 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV58_31790 ENOG4105CJ1 ABC, transporter FNV58_31800 ENOG4105II7 pyrroline-5-carboxylate reductase FNV58_31805 ENOG4105C31 Tryptophanyl-tRNA synthetase FNV58_31845 ENOG4105DGU Histone deacetylase FNV58_31850 ENOG4108XFF FNV58_31885 ENOG4108RXW HAD-superfamily subfamily IB hydrolase FNV58_31895 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) FNV58_31900 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FNV58_31905 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FNV58_31910 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FNV58_31915 ENOG4105D52 delta-aminolevulinic acid dehydratase FNV58_31945 ENOG4105C75 arginyL-tRNA synthetase FNV58_31950 ENOG4105DK7 lysyl-tRNA synthetase FNV58_31970 ENOG4105E0Y RtcB Protein FNV58_31990 ENOG4105KK4 UPF0060 membrane protein FNV58_32005 ENOG4105KVH Transcriptional regulator FNV58_32035 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FNV58_32040 ENOG4108UZX fmn reductase FNV58_32045 ENOG4105ETX regulatoR FNV58_32050 ENOG41062D9 Histidine kinase FNV58_32065 ENOG4105C0X amino acid FNV58_32075 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV58_32085 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_32100 ENOG4105D0M Protease HtpX homolog FNV58_32110 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FNV58_32120 ENOG4108ZJ4 polysaccharide deacetylase FNV58_32135 ENOG4105C0X amino acid FNV58_32155 ENOG4105D7N magnesium and cobalt transport protein CorA FNV58_32160 ENOG4107XWI flavin reductase domain protein, FMN-binding FNV58_32175 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FNV58_32180 ENOG4108RH7 phosphoglycerate mutase FNV58_32200 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) FNV58_32205 ENOG4105CRE cytochrome C FNV58_32250 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV58_32260 ENOG4105YVS arsR family transcriptional regulator FNV58_32280 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FNV58_32285 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) FNV58_32290 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FNV58_32300 ENOG4105DVY radical SAM domain protein FNV58_32315 ENOG4108R86 Transcriptional regulator FNV58_32325 ENOG4105CHR reductase FNV58_32330 ENOG4105CHU acetyl-coa acetyltransferase FNV58_32340 ENOG4105VEQ Cold shock protein FNV58_32345 ENOG4105EV6 Pfam:DUF178 FNV58_32360 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) FNV58_32380 ENOG4108ZJ4 polysaccharide deacetylase FNV58_32390 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV58_32400 ENOG4105KNA -acetyltransferase FNV58_32410 ENOG41068JE domain protein FNV58_32420 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV58_32425 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FNV58_32430 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV58_32440 ENOG4107QIZ NADH dehydrogenase FNV58_32445 ENOG4108IEH NADH dehydrogenase subunit g FNV58_32450 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FNV58_32455 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV58_32460 ENOG4105DF2 NADH dehydrogenase subunit j FNV58_32465 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV58_32470 ENOG4105D65 subunit l FNV58_32480 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV58_32485 ENOG4105C9U ATP-dependent DNA helicase RecQ FNV58_32490 ENOG4108IYU L-aspartate oxidase FNV58_32495 ENOG4108IY8 ABC, transporter FNV58_32515 ENOG4105FDP GntR family transcriptional regulator FNV58_32535 ENOG4105CAY ferredoxin--nadp reductase FNV58_32545 ENOG4108FKH Transglycosylase SLT domain FNV58_32575 ENOG4105CJ1 ABC, transporter FNV58_32585 ENOG4108WS4 fmn reductase FNV58_32610 ENOG4105ECR NmrA family FNV58_32615 ENOG4105KVH Transcriptional regulator FNV58_32620 ENOG4105DQU oxidoreductase, subunit beta FNV58_32625 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FNV58_32645 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FNV58_32650 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV58_32655 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FNV58_32660 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FNV58_32665 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV58_32670 ENOG4107YX3 NADH dehydrogenase subunit j FNV58_32675 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV58_32685 ENOG4105C8S subunit m FNV58_32690 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV58_32695 ENOG4105D0M Protease HtpX homolog FNV58_32700 ENOG410901E Membrane FNV58_32720 ENOG4105Y3U Transglycosylase-associated protein FNV58_32725 ENOG4108VPT UPF0234 protein FNV58_32805 ENOG4105CZE histidine utilization repressor FNV58_32835 ENOG4105DZC cytosine deaminase FNV58_32850 ENOG4105WDJ 50S ribosomal protein L33 FNV58_32855 ENOG410900P UPF0336 protein FNV58_32875 ENOG4107R4N Cell wall formation (By similarity) FNV58_32880 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FNV58_32895 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FNV58_32915 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FNV58_32920 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FNV58_32925 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FNV58_32935 ENOG4105QCJ Lipoprotein FNV58_32940 ENOG4108VZM 50s ribosomal protein L10 FNV58_32945 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FNV58_32955 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FNV58_32960 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FNV58_32990 ENOG4107V6Q Cyclic nucleotide-binding domain FNV58_32995 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FNV58_33000 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FNV58_33005 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FNV58_33010 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FNV58_33025 ENOG4106A3M Cytochrome p-450 FNV58_33045 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FNV58_33080 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FNV58_33085 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FNV58_33090 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FNV58_33095 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FNV58_33100 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FNV58_33105 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FNV58_33110 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FNV58_33115 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FNV58_33120 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FNV58_33125 ENOG41082SA 50s ribosomal protein l29 FNV58_33130 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FNV58_33135 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FNV58_33140 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FNV58_33145 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FNV58_33150 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FNV58_33160 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FNV58_33165 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FNV58_33170 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FNV58_33175 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FNV58_33180 ENOG410849U 50S ribosomal protein L30 FNV58_33185 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FNV58_33195 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FNV58_33205 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FNV58_33210 ENOG41067V7 50S ribosomal protein L36 FNV58_33215 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FNV58_33220 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FNV58_33225 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FNV58_33230 ENOG4108ZT0 50S ribosomal protein l17 FNV58_33235 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FNV58_33245 ENOG4107QZ7 Cellulose synthase catalytic subunit FNV58_33250 ENOG4108K2F hydrolase Family 5 FNV58_33265 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FNV58_33275 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FNV58_33280 ENOG4108UJD 30S ribosomal protein S9 FNV58_33285 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FNV58_33290 ENOG4105CS9 pantothenic acid kinase FNV58_33295 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FNV58_33355 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FNV58_33360 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 FNV58_33365 ENOG4108097 ATP-binding protein FNV58_33385 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FNV58_33395 ENOG4105ETE Transcriptional regulator (LacI family FNV58_33410 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FNV58_33415 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FNV58_33420 ENOG4105ETE Transcriptional regulator (LacI family FNV58_33445 ENOG4105CHP RNA polymerase FNV58_33470 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FNV58_33480 ENOG4105EMU Dehydrogenase FNV58_33490 ENOG4105DND Transcriptional regulator FNV58_33495 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FNV58_33500 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_33505 ENOG4108MMM RNA Polymerase FNV58_33515 ENOG4107QVP Dehydrogenase FNV58_33525 ENOG4107QQG Dehydrogenase FNV58_33530 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FNV58_33550 ENOG4107TPY serine threonine protein kinase FNV58_33555 ENOG4105D9P serine threonine protein kinase FNV58_33560 ENOG4107TPY serine threonine protein kinase FNV58_33565 ENOG4105C26 Dehydrogenase FNV58_33590 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FNV58_33635 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_33670 ENOG4105DR5 peptidase FNV58_33695 ENOG4105KKX ATPase associated with various cellular activities aaa_5 FNV58_33700 ENOG4105RD5 FNV58_33705 ENOG4105DEG Vwa containing coxe family protein FNV58_33720 ENOG4105CMV Succinyl-CoA synthetase subunit beta FNV58_33755 ENOG4105DC1 bifunctional purine biosynthesis protein purh FNV58_33775 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FNV58_33800 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FNV58_33820 ENOG410645S MarR family Transcriptional regulator FNV58_33825 ENOG4105C26 Dehydrogenase FNV58_33835 ENOG4108IJ7 Glycine betaine FNV58_33840 ENOG4108HQS Glycine betaine FNV58_33855 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FNV58_33860 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FNV58_33870 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FNV58_33880 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase FNV58_33890 ENOG4108ES0 acetoacetyl-CoA synthetase FNV58_33900 ENOG4108ZFD Antibiotic biosynthesis monooxygenase FNV58_33920 ENOG4106032 Glutathionylspermidine synthase FNV58_33925 ENOG4105C8Y Acetylornithine aminotransferase FNV58_33930 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FNV58_33940 ENOG4105C31 Tryptophanyl-tRNA synthetase FNV58_33975 ENOG4107H3J ribonuclease FNV58_33990 ENOG4107RN3 metallophosphoesterase FNV58_34010 ENOG4105BZU Histidine kinase FNV58_34015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV58_34020 ENOG4105EYF MMPL domain protein FNV58_34065 ENOG4108J01 L-aspartate oxidase FNV58_34085 ENOG4105E2D ec 3.2.1.52 FNV58_34120 ENOG4108MMM RNA Polymerase FNV58_34125 ENOG4108MMM RNA Polymerase FNV58_34140 ENOG4105D5P Methylmalonyl-coA mutase FNV58_34150 ENOG4108NIW Leucine export protein LeuE FNV58_34165 ENOG4105K64 Glycosyl transferase, family 2 FNV58_34175 ENOG4105F0R Cytidylyltransferase FNV58_34180 ENOG4105D2T synthase FNV58_34195 ENOG4105C8U phosphate abc transporter FNV58_34230 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FNV58_34235 ENOG4105K7W phage-related replication protein FNV58_34290 ENOG4107RM1 amidohydrolase FNV58_34295 ENOG4105DIH basic membrane FNV58_34300 ENOG4105DIH basic membrane FNV58_34305 ENOG4108JQ9 ABC transporter FNV58_34345 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FNV58_34350 ENOG4105D94 Major Facilitator Superfamily FNV58_34355 ENOG4107RSM transcriptional regulator FNV58_34365 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FNV58_34390 ENOG41065SU Two-component system sensor kinase FNV58_34395 ENOG4108KXV response regulator FNV58_34400 ENOG4105NAF rna polymerase sigma factor FNV58_34415 ENOG4105C26 Dehydrogenase FNV58_34420 ENOG4105C26 Dehydrogenase FNV58_34480 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FNV58_34495 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain FNV58_34525 ENOG4108JIK carboxylase FNV58_34535 ENOG4107WR6 Maf-like protein FNV58_34550 ENOG4105D8K carboxyl transferase FNV58_34560 ENOG4108QER Adenylate cyclase FNV58_34570 ENOG4105E39 Enoyl-CoA hydratase FNV58_34575 ENOG4105KDM Diguanylate cyclase with gaf sensor FNV58_34580 ENOG4105C84 Histidine ammonia-lyase FNV58_34585 ENOG4105VEQ Cold shock protein FNV58_34590 ENOG4105C1J atp-dependent rna helicase FNV58_34620 ENOG4105C19 ABC transporter FNV58_34645 ENOG4105DQ4 alcohol dehydrogenase FNV58_34650 ENOG4105TVJ transport system, permease FNV58_34655 ENOG4105DQ5 transport system permease protein FNV58_34665 ENOG4107R16 Multicopper oxidase FNV58_34705 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FNV58_34740 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FNV58_34765 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FNV58_34770 ENOG4105C7B Threonine dehydratase FNV58_34815 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FNV58_34825 ENOG4105T1M mycothiol conjugate amidase mca FNV58_34850 ENOG4105C7Z Conserved Protein FNV58_34885 ENOG4105C57 major facilitator superfamily FNV58_34895 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) FNV58_34935 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FNV58_34995 ENOG4105CHM Aminotransferase FNV58_35025 ENOG4108FUF Transcriptional regulator, IclR family FNV58_35030 ENOG4105KME endoribonuclease L-psp FNV58_35035 ENOG4105C6Z Gluconate FNV58_35095 ENOG4107QMS site-determining protein FNV58_35125 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_35145 ENOG4107QKZ Ompa motb domain protein FNV58_35150 ENOG4105NAE bifunctional deaminase-reductase domain protein FNV58_35180 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FNV58_35190 ENOG4108IAB Phoh family FNV58_35205 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FNV58_35210 ENOG4105D3R alkyl hydroperoxide reductase FNV58_35225 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV58_35245 ENOG4105BZ4 penicillin-binding protein FNV58_35260 ENOG4105CH6 catalase FNV58_35275 ENOG4105C9Q fumarate hydratase class II FNV58_35295 ENOG4107GFK fumarate FNV58_35305 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FNV58_35320 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) FNV58_35325 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FNV58_35330 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FNV58_35335 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FNV58_35350 ENOG4105C3G gtp-binding protein FNV58_35365 ENOG4107T94 Endo-14-beta-xylanase FNV58_35440 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FNV58_35460 ENOG4105CI3 gtp-binding protein typa FNV58_35465 ENOG4105DEF Extracellular solute-binding protein, family 5 FNV58_35475 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FNV58_35485 ENOG4108JQ7 (ABC) transporter FNV58_35490 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase FNV58_35500 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FNV58_35505 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FNV58_35510 ENOG4105C3U ABC transporter FNV58_35515 ENOG4108JQ7 (ABC) transporter FNV58_35530 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) FNV58_35550 ENOG4108M15 ABC transporter FNV58_35560 ENOG4105BZU Histidine kinase FNV58_35565 ENOG4108S01 response regulator FNV58_35580 ENOG4108Z4U Ferredoxin FNV58_35600 ENOG4107R4C succinyl-diaminopimelate desuccinylase FNV58_35605 ENOG4108URH decarboxylase FNV58_35610 ENOG4105EEI dihydropteroate synthase FNV58_35620 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FNV58_35625 ENOG4105CGU Enoyl-CoA hydratase FNV58_35640 ENOG4105DU6 RNA polymerase FNV58_35655 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FNV58_35680 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FNV58_35690 ENOG4105D7N magnesium and cobalt transport protein CorA FNV58_35700 ENOG4105DXB Major Facilitator superfamily FNV58_35715 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FNV58_35730 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FNV58_35775 ENOG4105DEF Extracellular solute-binding protein, family 5 FNV58_35780 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FNV58_35825 ENOG4106JDR secreted FNV58_35845 ENOG4105C4R Atp-dependent dna helicase FNV58_35850 ENOG4107QSE Dipeptidase FNV58_35875 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FNV58_35945 ENOG41063PX domain protein FNV58_35955 ENOG4105DJZ UPF0182 protein FNV58_35985 ENOG4105C2X Arabinose 5-phosphate isomerase FNV58_35990 ENOG4107TK4 histidinol-phosphate phosphatase FNV58_36000 ENOG4105KPY Small multidrug resistance protein FNV58_36010 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FNV58_36020 ENOG4108RAV Conserved protein FNV58_36030 ENOG4105EMN RNA polymerase sigma factor FNV58_36035 ENOG4105WMN AntiSigma factor FNV58_36040 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FNV58_36055 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FNV58_36065 ENOG41068W2 Cytochrome p-450 FNV58_36085 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FNV58_36090 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FNV58_36110 ENOG4105FDP GntR family transcriptional regulator FNV58_36130 ENOG4105D17 glycoside hydrolase, family 3 domain protein FNV58_36135 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FNV58_36140 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FNV58_36155 ENOG4105CBD Diacylglycerol kinase FNV58_36200 ENOG4105ESN nucleotide-binding protein FNV58_36260 ENOG4108VEQ Superoxide dismutase FNV58_36275 ENOG4107RBS Methyltransferase FNV58_36280 ENOG4105CDA abc transporter atp-binding protein FNV58_36300 ENOG4105C6K Malic enzyme FNV58_36305 ENOG4105CB2 alcohol dehydrogenase FNV58_36340 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FNV58_36345 ENOG4105EB3 Histidine kinase FNV58_36350 ENOG4108PYU two-component system response regulator FNV58_36380 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FNV58_36440 ENOG4108IG5 Transcriptional regulator FNV58_36465 ENOG4108PJD permease FNV58_36470 ENOG4105CJN penicillin-binding protein FNV58_36475 ENOG4107QHZ cell cycle protein FNV58_36485 ENOG4108FKE two-component system sensor kinase FNV58_36510 ENOG4105FDF Could be involved in DNA repair (By similarity) FNV58_36515 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FNV58_36625 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FNV58_36720 ENOG4105C2M dna polymerase I FNV58_36755 ENOG4105ETX regulatoR FNV58_36760 ENOG4105C75 arginyL-tRNA synthetase FNV58_36765 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FNV58_36770 ENOG4105D6E homoserine dehydrogenase FNV58_36775 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FNV58_36780 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FNV58_36790 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap FNV58_36795 ENOG4108KGH TRANSCRIPTIONal FNV58_36800 ENOG4105VFB Binds the 23S rRNA (By similarity) FNV58_36805 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FNV58_36810 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FNV58_36820 ENOG4107ZF2 Phosphatase FNV58_36830 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FNV58_36835 ENOG4105ESV Glycosyl transferase, family 4 FNV58_36840 ENOG4105Z3P ATP synthase FNV58_36850 ENOG4105ZA1 atp synthase FNV58_36855 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FNV58_36860 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FNV58_36865 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FNV58_36870 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FNV58_36875 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FNV58_36880 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FNV58_36895 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_36905 ENOG4105IIP Membrane FNV58_36920 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FNV58_36940 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) FNV58_36985 ENOG4105CJ1 ABC, transporter FNV58_37005 ENOG4105CHU acetyl-coa acetyltransferase FNV58_37040 ENOG4105VCH membrane FNV58_37080 ENOG4105WX6 Membrane FNV58_37125 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FNV58_37130 ENOG4105C6K Malic enzyme FNV58_37135 ENOG4105CTQ phosphohexokinase FNV58_37150 ENOG4105I1K ABC transporter FNV58_37175 ENOG4105DQ4 alcohol dehydrogenase FNV58_37180 ENOG4108MRH transcriptional regulatory protein FNV58_37185 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FNV58_37190 ENOG4105CK2 sodium dicarboxylate symporter FNV58_37200 ENOG4105C57 major facilitator superfamily FNV58_37235 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FNV58_37240 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) FNV58_37250 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) FNV58_37255 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin FNV58_37260 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FNV58_37280 ENOG4105BZ1 (ABC) transporter FNV58_37285 ENOG4105BZ1 (ABC) transporter FNV58_37290 ENOG4105BZ1 (ABC) transporter FNV58_37295 ENOG4105BZ1 (ABC) transporter FNV58_37300 ENOG4105CJ1 ABC, transporter FNV58_37310 ENOG4105BZU Histidine kinase FNV58_37315 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_37325 ENOG4105S7A ErfK ybiS ycfS ynhG family protein FNV58_37330 ENOG41069FZ L,D-transpeptidase catalytic domain FNV58_37380 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) FNV58_37410 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_37430 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FNV58_37465 ENOG4105CHR reductase FNV58_37480 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FNV58_37490 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FNV58_37515 ENOG4105EWK phytoene FNV58_37525 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FNV58_37545 ENOG4105WQT MbtH domain protein FNV58_37550 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_37550 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_37560 ENOG4105DNP FAD linked oxidase domain protein FNV58_37575 ENOG4108JQ1 Dehydrogenase FNV58_37580 ENOG4105EJQ L-serine dehydratase FNV58_37585 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FNV58_37590 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FNV58_37595 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FNV58_37615 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FNV58_37635 ENOG4108JQ7 (ABC) transporter FNV58_37650 ENOG4105EN6 Membrane FNV58_37670 ENOG4105D29 Helix-turn-helix type 11 domain protein FNV58_37710 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FNV58_37720 ENOG4108URH decarboxylase FNV58_37725 ENOG4105EMU Dehydrogenase FNV58_37735 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FNV58_37740 ENOG4105BZU Histidine kinase FNV58_37745 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FNV58_37750 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FNV58_37760 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FNV58_37765 ENOG4105EYF MMPL domain protein FNV58_37770 ENOG4105D9U N-acetyltransferase FNV58_37785 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_37800 ENOG4105CPC Aldo Keto reductase FNV58_37820 ENOG4108ZP8 Acetolactate synthase small subunit FNV58_37825 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FNV58_37835 ENOG4107SM8 Adenylate Guanylate cyclase FNV58_37840 ENOG4105C57 major facilitator superfamily FNV58_37860 ENOG4105T0Z Conserved Protein FNV58_37875 ENOG4105C26 Dehydrogenase FNV58_37890 ENOG4105CGS Alpha-glucosidase FNV58_37900 ENOG4105C0R drug resistance transporter emrb qaca subfamily FNV58_37915 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FNV58_37920 ENOG4105CM2 brancheD-chain amino acid aminotransferase FNV58_37945 ENOG4105CQM Urea amidohydrolase subunit alpha FNV58_37950 ENOG4105DWY Agmatine deiminase FNV58_37960 ENOG4105CSH Transporter FNV58_37965 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FNV58_37980 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FNV58_37995 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_38005 ENOG4105CJ1 ABC, transporter FNV58_38040 ENOG4105BZU Histidine kinase FNV58_38050 ENOG4108YYC ycei family FNV58_38055 ENOG4105D8K carboxyl transferase FNV58_38075 ENOG4105GWZ Roadblock lc7 family protein FNV58_38095 ENOG4105GWZ Roadblock lc7 family protein FNV58_38110 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FNV58_38115 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FNV58_38165 ENOG41069M3 Transcriptional regulator FNV58_38170 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FNV58_38175 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FNV58_38185 ENOG4105K70 DNA-binding protein FNV58_38195 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) FNV58_38205 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FNV58_38210 ENOG4105CPF Cell wall formation (By similarity) FNV58_38235 ENOG4105VB9 50S ribosomal protein l28 FNV58_38240 ENOG4105DP4 dak2 domain fusion protein ylov FNV58_38250 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FNV58_38260 ENOG4106H78 methyltransferase FNV58_38265 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FNV58_38280 ENOG41084BZ 50S ribosomal protein L32 FNV58_38285 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FNV58_38290 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FNV58_38295 ENOG4105KVH Transcriptional regulator FNV58_38310 ENOG4105D9P serine threonine protein kinase FNV58_38330 ENOG4105K4I Scp-like extracellular FNV58_38335 ENOG4108375 Acylphosphatase (EC 3.6.1.7) FNV58_38390 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FNV58_38400 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FNV58_38410 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) FNV58_38420 ENOG4105K5M 30s ribosomal protein S16 FNV58_38425 ENOG41082KU UPF0109 protein FNV58_38430 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FNV58_38435 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FNV58_38440 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FNV58_38450 ENOG4107QYR Signal peptidase i FNV58_38465 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FNV58_38475 ENOG41080R2 UPF0102 protein FNV58_38480 ENOG4105C0P Mg chelatase subunit ChlI FNV58_38490 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FNV58_38505 ENOG4105CE9 30S ribosomal protein S2 FNV58_38510 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FNV58_38515 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FNV58_38520 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FNV58_38525 ENOG4105KNE Phosphatidate cytidylyltransferase FNV58_38540 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FNV58_38570 ENOG4105CNU cell division protein FtsK FNV58_38610 ENOG4105GFG DUF218 domain FNV58_38660 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FNV58_38670 ENOG4108I5D sulfate abc transporter FNV58_38675 ENOG4108UCS ABC, transporter FNV58_38705 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV58_38710 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FNV58_38720 ENOG4105C26 Dehydrogenase FNV58_38785 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FNV58_38810 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FNV58_38815 ENOG4105F38 ABC transporter, permease FNV58_38820 ENOG4105D38 putrescine abc transporter FNV58_38825 ENOG4105CJP fad dependent oxidoreductase FNV58_38855 ENOG4105G9B Transcriptional regulator FNV58_38855 ENOG4105G9B Transcriptional regulator FNV58_38865 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FNV58_38870 ENOG4105E0S extracellular solute-binding protein family 1 FNV58_38880 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FNV58_38915 ENOG4107P2S Transcriptional regulator FNV58_38935 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FNV58_38945 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FNV58_38950 ENOG4105DZP Membrane-associated zinc metalloprotease FNV58_38955 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FNV58_38970 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FNV58_39000 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase FNV58_39015 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) FNV58_39030 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FNV58_39040 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FNV58_39045 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FNV58_39065 ENOG4105C3U ABC transporter FNV58_39070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FNV58_39075 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FNV58_39105 ENOG4108PZM peptidase S8 and S53, subtilisin, kexin, sedolisin FNV58_39180 ENOG4105EC2 ftsk spoIIIe FNV58_39195 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FNV58_39200 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FNV58_39205 ENOG4105C1V Peptidase, M16 FNV58_39210 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FNV58_39235 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FNV58_39240 ENOG4105CN5 Metallo-Beta-Lactamase FNV58_39285 ENOG4105BZU Histidine kinase FNV58_39290 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FNV58_39295 ENOG4107QZI cell division protein FtsK FNV58_39305 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) FNV58_39315 ENOG4105CEV competence damage-inducible protein FNV58_39320 ENOG4105WBV Transcriptional regulator FNV58_39325 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction FNV58_39335 ENOG4105CHR reductase FNV58_39340 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) FNV58_39345 ENOG4107QRT dEAD DEAH box helicase FNV58_39375 ENOG4105DSF transport protein FNV58_39385 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FNV58_39405 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FNV58_39415 ENOG4107SCK Monooxygenase FNV58_39420 ENOG4105DRP amino acid AbC transporter FNV58_39425 ENOG4108Q1T ABC transporter FNV58_39430 ENOG4107UBR Extracellular solute-binding protein family 3 FNV58_39435 ENOG4105CDA abc transporter atp-binding protein FNV58_39440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV58_39445 ENOG4105EB3 Histidine kinase FNV58_39470 ENOG4105BZU Histidine kinase FNV58_39475 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_39505 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FNV58_39515 ENOG410836F Transposase FNV58_39530 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FNV58_39540 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FNV58_39545 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FNV58_39555 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FNV58_39595 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FNV58_39600 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FNV58_39605 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FNV58_39620 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FNV58_39640 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FNV58_39655 ENOG4105C9U ATP-dependent DNA helicase RecQ FNV58_39670 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FNV58_39675 ENOG4105CJ1 ABC, transporter FNV58_39680 ENOG4105DRR Transcriptional regulator, GntR family FNV58_39685 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FNV58_39690 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap FNV58_39700 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FNV58_39715 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_39725 ENOG4107QN1 sodium solute FNV58_39730 ENOG4108V9W transcriptional regulatory protein FNV58_39740 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FNV58_39750 ENOG4108MRH transcriptional regulatory protein FNV58_39770 ENOG4105BZN citrate synthase FNV58_39790 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FNV58_39805 ENOG41061JJ Peptidase family M23 FNV58_39810 ENOG4105DRR Transcriptional regulator, GntR family FNV58_39815 ENOG410849S phosphocarrier protein (HPr) FNV58_39825 ENOG4105CD5 CoA-binding domain protein FNV58_39840 ENOG4107W53 thymidine kinase FNV58_39875 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FNV58_39885 ENOG4105F44 Two component transcriptional regulator, winged helix family FNV58_39890 ENOG4106F60 Histidine kinase FNV58_39915 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FNV58_39930 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FNV58_39960 ENOG4107VEG TrkA-N domain protein FNV58_39965 ENOG4105C0X amino acid FNV58_39970 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FNV58_39975 ENOG4105C7K acetolactate synthase FNV58_40030 ENOG4105BZU Histidine kinase FNV58_40035 ENOG4105EYF MMPL domain protein FNV58_40050 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FNV58_40085 ENOG4107S1Q Phosphatase FNV58_40100 ENOG4105CEU Arginine dihydrolase FNV58_40105 ENOG4105DBV ornithine carbamoyltransferase FNV58_40110 ENOG4105CUB amino acid FNV58_40120 ENOG4105CGU Enoyl-CoA hydratase FNV58_40165 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FNV58_40185 ENOG4107QM5 aconitate hydratase FNV58_40195 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FNV58_40205 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV58_40210 ENOG4105BZU Histidine kinase FNV58_40225 ENOG4105CWX Alpha-1,2-mannosidase FNV58_40240 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FNV58_40250 ENOG4105E2R ROK family FNV58_40255 ENOG4105DFW ABC transporter FNV58_40260 ENOG4105C2J ABC transporter FNV58_40265 ENOG4107RNG ABC transporter FNV58_40270 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FNV58_40275 ENOG4105CUB amino acid FNV58_40310 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FNV58_40315 ENOG4105CHU acetyl-coa acetyltransferase FNV58_40325 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) FNV58_40340 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FNV58_40355 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FNV58_40365 ENOG4105C1Q protoporphyrinogen oxidase FNV58_40370 ENOG4107JTW chlorite dismutase FNV58_40390 ENOG4105E18 UPF0276 protein FNV58_40425 ENOG4105CSR polyphosphate kinase 2 FNV58_40430 ENOG4105C22 threonyL-tRNA synthetase FNV58_40445 ENOG4107B2H carbonic anhydrase FNV58_40470 ENOG4105DFU Cell wall formation (By similarity) FNV58_40475 ENOG4105E0X reductase FNV58_40485 ENOG4107TPY serine threonine protein kinase FNV58_40520 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding FNV58_40565 ENOG4105BZU Histidine kinase FNV58_40570 ENOG4105BZU Histidine kinase FNV58_40590 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FNV58_40605 ENOG4105EDW glycosyl transferase, family 39 FNV58_40630 ENOG4105DHQ Histidine kinase FNV58_40725 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FNV58_40730 ENOG4105DUM transcriptional regulator, lysR family FNV58_40740 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FNV58_40770 ENOG4105ZSU inhibitor FNV58_40865 ENOG4107S5I aldo keto reductase FNV58_40870 ENOG4105D7V transposase FNV58_40885 ENOG4105MC2 DSBA oxidoreductase FNV58_40900 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FNV58_40905 ENOG4108IY8 ABC, transporter FNV58_40935 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FNV58_40960 ENOG4107RR1 TRANSCRIPTIONal FNV58_40965 ENOG4105CSU acyl-Coa dehydrogenase FNV58_40980 ENOG4105E7U AraC family transcriptional regulator FNV58_41010 ENOG4105ETE Transcriptional regulator (LacI family FNV58_41035 ENOG4105EBR Carboxylesterase FNV58_41040 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FNV58_41050 ENOG4108J5H Homocysteine s-methyltransferase FNV58_41105 ENOG4105K4I Scp-like extracellular FNV58_41110 ENOG4108VQT Alpha beta hydrolase fold protein FNV58_41190 ENOG4105CJ1 ABC, transporter FNV58_41225 ENOG4105QE3 oxidoreductase FNV58_41300 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FNV58_41340 ENOG4105C7K acetolactate synthase FNV58_41360 ENOG4105DRR Transcriptional regulator, GntR family FNV58_41390 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FNV58_41395 ENOG4105C7N Xanthine uracil vitamin C permease FNV58_41425 ENOG4108ZJ4 polysaccharide deacetylase FNV58_41430 ENOG4105DDC Oxidoreductase domain protein FNV58_41450 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) FNV58_41455 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FNV58_41475 ENOG4105CJ2 (LipO)protein FNV58_41490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV58_41495 ENOG4105BZU Histidine kinase FNV58_41540 ENOG4105ECQ AraC Family Transcriptional Regulator FNV58_41575 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FNV58_41590 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FNV58_41595 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FNV58_41615 ENOG4107SCA Formamidase (EC 3.5.1.49) FNV58_41620 ENOG4105IW1 AmiS UreI transporter FNV58_41670 ENOG4105D9R oxidoreductase FNV58_41675 ENOG4105CPC Aldo Keto reductase FNV58_41725 ENOG4105D74 hydrolase FNV58_41745 ENOG4105D7N magnesium and cobalt transport protein CorA FNV58_41755 ENOG410829K Lysine exporter protein (Lyse ygga) FNV58_41760 ENOG4106NZI LysR family Transcriptional regulator FNV58_41770 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap FNV58_41785 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FNV58_41790 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_41800 ENOG41060W2 glyoxylate carboligase FNV58_41810 ENOG4105CH6 catalase FNV58_41815 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FNV58_41820 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FNV58_41840 ENOG4105VT2 5-hydroxyisourate hydrolase FNV58_41850 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FNV58_41870 ENOG4105KVH Transcriptional regulator FNV58_41885 ENOG4108ZM9 phosphoglycerate mutase FNV58_41890 ENOG4105CHM Aminotransferase FNV58_41895 ENOG4107YPT transcriptional regulator FNV58_41915 ENOG4105DUU IucA IucC family protein FNV58_41925 ENOG4105D9P serine threonine protein kinase FNV58_41945 ENOG4107R9S Malate synthase FNV58_41950 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FNV58_41960 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FNV58_41975 ENOG4107HP6 Transcriptional regulator FNV58_41990 ENOG4105D7N magnesium and cobalt transport protein CorA FNV58_42005 ENOG4105CPC Aldo Keto reductase FNV58_42010 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_42020 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FNV58_42025 ENOG4105FDP GntR family transcriptional regulator FNV58_42040 ENOG4105CNN ABC, transporter FNV58_42045 ENOG4105C2J ABC transporter FNV58_42050 ENOG4105DKQ ROK family FNV58_42060 ENOG4105C0D helicase FNV58_42100 ENOG4105CHR reductase FNV58_42105 ENOG4105CHR reductase FNV58_42125 ENOG41082BM Transcriptional regulator, arsr family FNV58_42210 ENOG4105C3K feS assembly ATPase SufC FNV58_42225 ENOG4105CFG Acts as a chaperone (By similarity) FNV58_42230 ENOG410827T Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FNV58_42235 ENOG4105DVC DnaJ domain protein FNV58_42245 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FNV58_42260 ENOG4108JU3 Alkyl hydroperoxide reductase FNV58_42285 ENOG4105F9F transposase FNV58_42345 ENOG4105D5G Transposase FNV58_42520 ENOG4108VHC Short-chain dehydrogenase reductase Sdr FNV58_42540 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FNV58_42550 ENOG4108HKT sucrose-6-phosphate hydrolase FNV58_42555 ENOG4105ETE Transcriptional regulator (LacI family FNV58_42570 ENOG4105DRS transport system, permease FNV58_42585 ENOG4105D74 hydrolase FNV58_42600 ENOG4105E1F short-chain dehydrogenase reductase FNV58_42615 ENOG4105ECB domain protein FNV58_42625 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FNV58_42650 ENOG4107R13 MMPL domain protein FNV58_42660 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) FNV58_42680 ENOG4105E1F short-chain dehydrogenase reductase FNV58_42765 ENOG4105EMU Dehydrogenase FNV58_42825 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FNV58_42830 ENOG4105E8R UPF0173 metal-dependent hydrolase FNV58_42845 ENOG4105CDA abc transporter atp-binding protein FNV58_42855 ENOG4105EAD ABC transporter FNV58_42860 ENOG4105DRP amino acid AbC transporter FNV58_42875 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FNV58_42900 ENOG4105C8Y Acetylornithine aminotransferase FNV58_42915 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) FNV58_42925 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FNV58_42935 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV58_42945 ENOG4105BZU Histidine kinase FNV58_42950 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_42965 ENOG4105ECY inositol monophosphatase FNV58_42980 ENOG4108UVJ appr-1-p processing domain protein FNV58_42990 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FNV58_42995 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FNV58_43005 ENOG4105K64 Glycosyl transferase, family 2 FNV58_43015 ENOG4105EQQ protein containing aminopeptidase domain FNV58_43030 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FNV58_43040 ENOG4105E2K Glycosyl transferase (Group 1 FNV58_43060 ENOG4107RRD Dehydrogenase FNV58_43065 ENOG4105CAQ asparagine synthetase FNV58_43085 ENOG4105C6Y Udp-glucose 6-dehydrogenase FNV58_43090 ENOG4105D3Q Sugar transferase FNV58_43105 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FNV58_43110 ENOG4106NZI LysR family Transcriptional regulator FNV58_43120 ENOG4105CBP Major Facilitator FNV58_43135 ENOG41060BG Tetr family transcriptional regulator FNV58_43185 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV58_43190 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV58_43200 ENOG4105EB3 Histidine kinase FNV58_43205 ENOG4106F60 Histidine kinase FNV58_43210 ENOG4105ETX regulatoR FNV58_43215 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FNV58_43235 ENOG41066UM arsR family transcriptional regulator FNV58_43255 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FNV58_43305 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FNV58_43310 ENOG4108Z6Z Transcriptional regulator FNV58_43315 ENOG4105C2U cobyrinic Acid a,c-diamide synthase FNV58_43345 ENOG4105BZW Glycerate kinase FNV58_43355 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme FNV58_43360 ENOG4105C1G acyl-Coa dehydrogenase FNV58_43370 ENOG4105CI0 Citrate lyase FNV58_43375 ENOG4105RFZ Methylmalonyl-coA mutase FNV58_43380 ENOG4105EE1 crotonyl-CoA reductase FNV58_43390 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FNV58_43400 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FNV58_43410 ENOG4106JDR secreted FNV58_43430 ENOG4108Q50 Histidine kinase FNV58_43475 ENOG4108ME1 Peptidase M55 D-aminopeptidase FNV58_43480 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FNV58_43490 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FNV58_43520 ENOG4105CV1 Transketolase (EC 2.2.1.1) FNV58_43525 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV58_43535 ENOG4105C5H ABC transporter FNV58_43545 ENOG4108Z0Z intracellular protease Pfpi family FNV58_43625 ENOG4105CFG Acts as a chaperone (By similarity) FNV58_43640 ENOG410842T Pterin carbinolamine dehydratase FNV58_43645 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV58_43660 ENOG4105D29 Helix-turn-helix type 11 domain protein FNV58_43665 ENOG4105CX8 fg-gap repeat protein FNV58_43675 ENOG4105CYP glycoside hydrolase, family FNV58_43680 ENOG41065HY 1,4-beta-cellobiosidase FNV58_43685 ENOG41065HY 1,4-beta-cellobiosidase FNV58_43705 ENOG4108HMN Caspase domain FNV58_43710 ENOG4105EMU Dehydrogenase FNV58_43720 ENOG4105CV8 reductase FNV58_43745 ENOG4105F5H Glycosyl Hydrolase Family 88 FNV58_43755 ENOG4106UDK Cellulose-binding, family II FNV58_43780 ENOG4105DUM transcriptional regulator, lysR family FNV58_43785 ENOG4105DHU Bile acid FNV58_43795 ENOG4108478 ec 3.2.1.18 FNV58_43805 ENOG4108VHT MarR family transcriptional regulator FNV58_43810 ENOG4105D3W isochorismatase FNV58_43820 ENOG4106NZI LysR family Transcriptional regulator FNV58_43825 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FNV58_43840 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FNV58_43845 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FNV58_43855 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FNV58_43890 ENOG4105DKQ ROK family FNV58_43895 ENOG4105C2J ABC transporter FNV58_43900 ENOG4105CNN ABC, transporter FNV58_43905 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FNV58_43950 ENOG4105F8V Hydrolase, tatD family FNV58_43975 ENOG4105FCD Major Facilitator FNV58_43995 ENOG4105CMV Succinyl-CoA synthetase subunit beta FNV58_44005 ENOG4105C26 Dehydrogenase FNV58_44065 ENOG4107TXC Transcriptional regulator FNV58_44105 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FNV58_44120 ENOG4105HFT AraC family transcriptional regulator FNV58_44135 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV58_44155 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands FNV58_44165 ENOG4105EMU Dehydrogenase FNV58_44180 ENOG4105KNA -acetyltransferase FNV58_44190 ENOG4105D9P serine threonine protein kinase FNV58_44210 ENOG4105NRA 50s ribosomal protein l31 type b FNV58_44225 ENOG4105BZU Histidine kinase FNV58_44230 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_44250 ENOG4105D7V transposase FNV58_44265 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FNV58_44270 ENOG4107S2E monooxygenase FNV58_44290 ENOG4105CPP Dehydrogenase, E1 component FNV58_44295 ENOG4108RZE Tetr family transcriptional regulator FNV58_44300 ENOG4105C1G acyl-Coa dehydrogenase FNV58_44305 ENOG4105CPQ Dehydrogenase FNV58_44315 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_44320 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FNV58_44325 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FNV58_44330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV58_44340 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FNV58_44370 ENOG4105C0R drug resistance transporter emrb qaca subfamily FNV58_44375 ENOG4105CHR reductase FNV58_44385 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FNV58_44410 ENOG4105C1G acyl-Coa dehydrogenase FNV58_44415 ENOG410846T CoA-transferase family III FNV58_44425 ENOG4108M9J MaoC like domain protein FNV58_44440 ENOG4105CPQ Dehydrogenase FNV58_44450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV58_44465 ENOG4106A3M Cytochrome p-450 FNV58_44500 ENOG4105D7V transposase FNV58_44535 ENOG4105DRP amino acid AbC transporter FNV58_44540 ENOG4105CDA abc transporter atp-binding protein FNV58_44545 ENOG4105EAB amino acid AbC transporter FNV58_44555 ENOG4105CPU Monooxygenase FNV58_44560 ENOG4105CPU Monooxygenase FNV58_44565 ENOG4105DEN Luciferase family FNV58_44570 ENOG4105DEN Luciferase family FNV58_44585 ENOG4107TTQ Alpha beta hydrolase fold FNV58_44595 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FNV58_44620 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FNV58_44640 ENOG4107QJN gtp cyclohydrolase ii FNV58_44680 ENOG410905P Pyridoxamine 5-phosphate FNV58_44695 ENOG4105CSH Transporter FNV58_44705 ENOG4107S9B Shikimate dehydrogenase FNV58_44725 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FNV58_44735 ENOG4107QP8 phosphohexose isomerase FNV58_44750 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FNV58_44785 ENOG4105CHR reductase FNV58_44810 ENOG41088CQ domain protein FNV58_44815 ENOG4105CNT hydrolase family 2 FNV58_44820 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FNV58_44835 ENOG4108MGF sugar kinase FNV58_44840 ENOG4105E98 transcriptional regulator DeoR family FNV58_44845 ENOG4105F8D glycoside hydrolase family 4 FNV58_44855 ENOG4106UDK Cellulose-binding, family II FNV58_44920 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FNV58_44925 ENOG4107TYH extracellular solute-binding protein family 1 FNV58_44930 ENOG4105D81 ABC transporter, permease FNV58_44935 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component FNV58_44950 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FNV58_44955 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FNV58_44960 ENOG4105CTU Proline racemase FNV58_44995 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FNV58_45000 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FNV58_45005 ENOG4105CG3 alpha amylase, catalytic region FNV58_45020 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FNV58_45290 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FNV58_45295 ENOG4105CSH Transporter FNV58_45310 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FNV58_45315 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FNV58_45330 ENOG4105CHU acetyl-coa acetyltransferase FNV58_45345 ENOG41067TZ transcriptional regulator, MarR family FNV58_45355 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FNV58_45390 ENOG4105DQE DNA ligase FNV58_45395 ENOG4105ETE Transcriptional regulator (LacI family FNV58_45410 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FNV58_45450 ENOG4106V2I dimethylaminohydrolase FNV58_45455 ENOG4105C5H ABC transporter FNV58_45465 ENOG4105CR4 methylisocitrate lyase FNV58_45470 ENOG4105KF0 sporulation and cell division protein, SsgA FNV58_45485 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) FNV58_45490 ENOG4105EG6 Saccharopine dehydrogenase FNV58_45495 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FNV58_45500 ENOG4105DYW oxidoreductase FNV58_45510 ENOG4105CHU acetyl-coa acetyltransferase FNV58_45515 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FNV58_45535 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FNV58_45560 ENOG4105C5H ABC transporter FNV58_45570 ENOG4105BZM domain protein FNV58_45590 ENOG4105E39 Enoyl-CoA hydratase FNV58_45605 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FNV58_45610 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FNV58_45635 ENOG4108MDK Dehydrogenase FNV58_45655 ENOG4105EY8 ABC transporter FNV58_45660 ENOG4105FBD synthase FNV58_45670 ENOG4107S11 squalene-associated FAD-dependent desaturase FNV58_45680 ENOG4105EWU Squalene--hopene cyclase FNV58_45695 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FNV58_45720 ENOG4105M2Z protein tyrosine serine phosphatase FNV58_45735 ENOG4105CX8 fg-gap repeat protein FNV58_45745 ENOG41090WU lipolytic protein G-D-S-L family FNV58_45760 ENOG4105D82 Glutamate dehydrogenase FNV58_45765 ENOG4105C7K acetolactate synthase FNV58_45805 ENOG4105CPQ Dehydrogenase FNV58_45810 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FNV58_45815 ENOG4106NZI LysR family Transcriptional regulator FNV58_45880 ENOG4105BZ1 (ABC) transporter FNV58_45910 ENOG4105C0F tryptophanase EC 4.1.99.1 FNV58_45930 ENOG4105XTG Pfam:DUF156 FNV58_45950 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) FNV58_45980 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold FNV58_46095 ENOG4105DWF phosphomethylpyrimidine kinase FNV58_46100 ENOG4105ECR NmrA family FNV58_46150 ENOG4108KPJ rna polymerase sigma factor FNV58_46160 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FNV58_46180 ENOG4108ZHJ Organic hydroperoxide resistance protein FNV58_46185 ENOG4108KPJ rna polymerase sigma factor FNV58_46245 ENOG41079R3 acyl carrier protein FNV58_46255 ENOG4105KTE polyketide synthesis cyclase FNV58_46270 ENOG4105E9K Isocitrate dehydrogenase FNV58_46275 ENOG4105D64 Mechanosensitive ion channel FNV58_46280 ENOG4105E39 Enoyl-CoA hydratase FNV58_46295 ENOG4105EYF MMPL domain protein FNV58_46305 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FNV58_46315 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FNV58_46330 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FNV58_46345 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FNV58_46365 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FNV58_46380 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FNV58_46405 ENOG4105CM2 brancheD-chain amino acid aminotransferase FNV58_46410 ENOG4105C5I Dehydrogenase FNV58_46425 ENOG4105CIH Imidazole acetol-phosphate transaminase FNV58_46430 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FNV58_46435 ENOG4105T38 integral membrane protein FNV58_46440 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FNV58_46450 ENOG4105D5U fad dependent oxidoreductase FNV58_46460 ENOG4108Z4U Ferredoxin FNV58_46465 ENOG4105C5Q Transcriptional regulator FNV58_46500 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FNV58_46520 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FNV58_46540 ENOG4107QPH glycogen) synthase FNV58_46545 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FNV58_46555 ENOG4107S4F acyltransferase, ws dgat mgat FNV58_46565 ENOG4105FQP Beta-lactamase FNV58_46570 ENOG4108R85 Short chain dehydrogenase FNV58_46580 ENOG4108M4U conserved membrane protein FNV58_46625 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FNV58_46645 ENOG41073TP transcriptional regulator FNV58_46655 ENOG4105C2J ABC transporter FNV58_46660 ENOG4105CNN ABC, transporter FNV58_46665 ENOG4105DIA mandelate racemase muconate lactonizing FNV58_46670 ENOG4105CHR reductase FNV58_46735 ENOG4105CRK lysyL-tRNA synthetase FNV58_46740 ENOG4108ZJ4 polysaccharide deacetylase FNV58_46785 ENOG4105BZU Histidine kinase FNV58_46790 ENOG4108R85 Short chain dehydrogenase FNV58_46795 ENOG4105C5Q Transcriptional regulator FNV58_46810 ENOG4105E33 succinate dehydrogenase FNV58_46830 ENOG4105DEN Luciferase family FNV58_46845 ENOG4105CPC Aldo Keto reductase FNV58_46880 ENOG4105DU6 RNA polymerase FNV58_46920 ENOG4105F27 Major Facilitator FNV58_46925 ENOG4108KB2 LysR family Transcriptional regulator FNV58_46930 ENOG4107RSM transcriptional regulator FNV58_46940 ENOG4105ENX hydrolase FNV58_46945 ENOG4105C7W Xanthine dehydrogenase FNV58_46950 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding FNV58_46955 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit FNV58_46970 ENOG4107SET aldo keto reductase FNV58_47000 ENOG41067HS methyltransferase FNV58_47005 ENOG4108V75 Glutamine amidotransferase FNV58_47010 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process FNV58_47015 ENOG4105D1K glutamate--cysteine ligase FNV58_47035 ENOG4105DZ6 Band 7 protein FNV58_47050 ENOG41060NJ transcriptional regulator FNV58_47055 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase FNV58_47065 ENOG41080RH Thioredoxin FNV58_47075 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FNV58_47120 ENOG4105EUB pirin domain protein FNV58_47145 ENOG41073TP transcriptional regulator FNV58_47155 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FNV58_47170 ENOG4107RN3 metallophosphoesterase FNV58_47225 ENOG4105D29 Helix-turn-helix type 11 domain protein FNV58_47250 ENOG4105ETE Transcriptional regulator (LacI family FNV58_47265 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FNV58_47310 ENOG4105FP9 thiamine pyrophosphate FNV58_47315 ENOG4105CHR reductase FNV58_47320 ENOG4108XG4 DNA-binding transcriptional regulator FNV58_47325 ENOG4105E1F short-chain dehydrogenase reductase FNV58_47335 ENOG4105DMF Dehydrogenase FNV58_47355 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FNV58_47360 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FNV58_47395 ENOG4105CR4 methylisocitrate lyase FNV58_47435 ENOG4105KVH Transcriptional regulator FNV58_47450 ENOG4105F6J Alpha beta hydrolase fold FNV58_47460 ENOG4105CIG ABC transporter FNV58_47500 ENOG4108M0I Transcriptional regulator FNV58_47505 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FNV58_47510 ENOG41073TP transcriptional regulator FNV58_47530 ENOG4105F95 Monooxygenase FNV58_47535 ENOG4105CPC Aldo Keto reductase FNV58_47540 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FNV58_47575 ENOG4105CHU acetyl-coa acetyltransferase FNV58_47605 ENOG41061ZR Transcriptional regulator FNV58_47630 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) FNV58_47685 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FNV58_47690 ENOG4105KNA -acetyltransferase FNV58_47705 ENOG4105CWX Alpha-1,2-mannosidase FNV58_47720 ENOG4108M8W Monooxygenase FNV58_47740 ENOG4105CSH Transporter FNV58_47760 ENOG4107T6F Xaa-Pro aminopeptidase FNV58_47765 ENOG4107MM9 BNR Asp-box repeat-containing protein FNV58_47775 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FNV58_47790 ENOG4105ETE Transcriptional regulator (LacI family FNV58_47795 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) FNV58_47820 ENOG4105J0Q Transcriptional regulator FNV58_47825 ENOG4105CIS alcohol dehydrogenase FNV58_47830 ENOG4108JJB ABC transporter FNV58_47835 ENOG4108JJB ABC transporter FNV58_47840 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FNV58_47865 ENOG410667J hydrolase FNV58_47940 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FNV58_47945 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FNV58_47950 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit FNV58_47955 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit FNV58_47960 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FNV58_47965 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FNV58_47975 ENOG4105CHU acetyl-coa acetyltransferase FNV58_47985 ENOG4108ZJI phenylacetic acid degradation protein FNV58_47995 ENOG4106T9R serine protease FNV58_48000 ENOG4107QTZ amino acid FNV58_48070 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FNV58_48095 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FNV58_48105 ENOG4105DPX Hydrogenase, large subunit FNV58_48135 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) FNV58_48155 ENOG4105CQS hydrogenase expression formation protein HypD FNV58_48175 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FNV58_48190 ENOG41084T3 4fe-4S ferredoxin iron-sulfur binding domain-containing protein FNV58_48220 ENOG4105C19 ABC transporter FNV58_48225 ENOG4105E90 ABC transporter FNV58_48230 ENOG4105E90 ABC transporter FNV58_48240 ENOG4108TM9 integral membrane protein FNV58_48250 ENOG4108IJ8 ABC transporter FNV58_48255 ENOG41080R8 Conserved Protein FNV58_48260 ENOG4107QR9 Iron-sulfur cluster binding protein FNV58_48265 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FNV58_48270 ENOG4105DET Rhamnulokinase FNV58_48285 ENOG4105C2J ABC transporter FNV58_48305 ENOG4105D4B ABC, transporter FNV58_48320 ENOG4105ETE Transcriptional regulator (LacI family FNV58_48330 ENOG4108KPJ rna polymerase sigma factor FNV58_48335 ENOG4105DDN Pentapeptide repeat-containing protein FNV58_48340 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FNV58_48345 ENOG4108R86 Transcriptional regulator FNV58_48355 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FNV58_48410 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FNV58_48415 ENOG4105D56 permease protein FNV58_48455 ENOG4105DCG PHP domain protein FNV58_48505 ENOG4105NAE bifunctional deaminase-reductase domain protein FNV58_48530 ENOG4107TPY serine threonine protein kinase FNV58_48580 ENOG41082SX arsR family transcriptional regulator FNV58_48590 ENOG4105CNI cell division protein FtsW FNV58_48620 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FNV58_48625 ENOG4107TB5 TRANSCRIPTIONal FNV58_48635 ENOG4105VEQ Cold shock protein FNV58_48670 ENOG4105CJA serine threonine protein kinase FNV58_48695 ENOG4107QTZ amino acid FNV58_48780 ENOG4105KF0 sporulation and cell division protein, SsgA FNV58_48830 ENOG4105ETE Transcriptional regulator (LacI family FNV58_48835 ENOG4105C2J ABC transporter FNV58_48840 ENOG4105CNN ABC, transporter FNV58_48845 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator FNV58_48855 ENOG4108HKT sucrose-6-phosphate hydrolase FNV58_48935 ENOG4108Q50 Histidine kinase FNV58_48965 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FNV58_49090 ENOG4105ETX regulatoR FNV58_49150 ENOG4107R16 Multicopper oxidase FNV58_49160 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV58_49175 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FNV58_49195 ENOG4105C26 Dehydrogenase FNV58_49210 ENOG4105ECQ AraC Family Transcriptional Regulator FNV58_49235 ENOG4107RCI amp-dependent synthetase and ligase FNV58_49245 ENOG4105CUB amino acid FNV58_49285 ENOG4106YKD Cytochrome p-450 FNV58_49325 ENOG4105EBM Alpha Beta Hydrolase Fold protein FNV58_49330 ENOG4107SM8 Adenylate Guanylate cyclase FNV58_49360 ENOG4105CNT hydrolase family 2 FNV58_49365 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FNV58_49390 ENOG41082BM Transcriptional regulator, arsr family FNV58_49425 ENOG4108JQ1 Dehydrogenase FNV58_49430 ENOG4105DMF Dehydrogenase FNV58_49455 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FNV58_49465 ENOG4106C4P Strong inhibitor of bacterial serine proteases such as subtilisin (By similarity) FNV58_49475 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FNV58_49485 ENOG41060NJ transcriptional regulator FNV58_49500 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FNV58_49520 ENOG4108JJA ABC, transporter FNV58_49525 ENOG4108JJA ABC, transporter FNV58_49560 ENOG4105EXC Acyl-transferase FNV58_49575 ENOG4105XRQ Xanthine dehydrogenase accessory factor FNV58_49625 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 FNV58_49640 ENOG4105BZ9 Cytochrome C oxidase, subunit I FNV58_49655 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FNV58_49690 ENOG4105DFW ABC transporter FNV58_49725 ENOG4105C5X domain protein FNV58_49730 ENOG4105CHR reductase FNV58_49760 ENOG4105E2R ROK family FNV58_49780 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FNV58_49805 ENOG4108KPJ rna polymerase sigma factor FNV58_49825 ENOG4108J20 pectate lyase FNV58_49850 ENOG4105EQX glucarate dehydratase FNV58_49860 ENOG4107RSM transcriptional regulator FNV58_49885 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FNV58_49965 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FNV58_49970 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FNV58_49980 ENOG4107R13 MMPL domain protein FNV58_50010 ENOG4105CHR reductase FNV58_50015 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FNV58_50030 ENOG41068HZ 50S ribosomal protein L32 FNV58_50075 ENOG4108PVQ transcriptional regulator FNV58_50135 ENOG4105JAB phenazine biosynthesis protein, phzf family FNV58_50145 ENOG4107RSM transcriptional regulator FNV58_50170 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FNV58_50220 ENOG4105VEQ Cold shock protein FNV58_50245 ENOG4105DEG Vwa containing coxe family protein FNV58_50250 ENOG4105KKX ATPase associated with various cellular activities aaa_5 FNV58_50280 ENOG4108JPW Aminotransferase FNV58_50290 ENOG4105FQP Beta-lactamase FNV58_50315 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FNV58_50330 ENOG41066F8 ROK family FNV58_50340 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FNV58_50345 ENOG4105DRS transport system, permease FNV58_50370 ENOG4105K4I Scp-like extracellular FNV58_50410 ENOG4105EGE secreted protein FNV58_50415 ENOG4106UDK Cellulose-binding, family II FNV58_50435 ENOG4107SET aldo keto reductase FNV58_50445 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FNV58_50450 ENOG4105CWX Alpha-1,2-mannosidase FNV58_50495 ENOG4108R85 Short chain dehydrogenase FNV58_50500 ENOG4105D2B acyl-CoA dehydrogenase FNV58_50505 ENOG4105E39 Enoyl-CoA hydratase FNV58_50520 ENOG4105CC9 acyl-Coa dehydrogenase FNV58_50530 ENOG4105C1G acyl-Coa dehydrogenase FNV58_50535 ENOG4105CHR reductase FNV58_50540 ENOG4105CHR reductase FNV58_50545 ENOG4108UKI Enoyl-CoA hydratase FNV58_50575 ENOG4105C5X domain protein FNV58_50590 ENOG4105CI2 imidazolone-5-propionate hydrolase FNV58_50595 ENOG4107TPY serine threonine protein kinase FNV58_50640 ENOG4108VCT Sulfite exporter TauE/SafE FNV58_50645 ENOG4105VPX protein, conserved in bacteria FNV58_50685 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FNV58_50700 ENOG4105ETE Transcriptional regulator (LacI family FNV58_50710 ENOG4105EX0 alpha-galactosidase FNV58_50720 ENOG4107S5I aldo keto reductase FNV58_50725 ENOG4105CHJ isochorismatase hydrolase FNV58_50745 ENOG4105CUX Signal transduction histidine kinase FNV58_50750 ENOG4105C3M thioredoxin reductase FNV58_50780 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FNV58_50790 ENOG4105F27 Major Facilitator FNV58_50815 ENOG4105IDI abc transporter atp-binding protein FNV58_50850 ENOG4105DR5 peptidase FNV58_50875 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FNV58_50895 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_50905 ENOG4105C4C beta-galactosidase FNV58_50930 ENOG4105D3W isochorismatase FNV58_50945 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FNV58_50965 ENOG4105BZU Histidine kinase FNV58_50975 ENOG4108U3T pfkb domain protein FNV58_50980 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein FNV58_51045 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) FNV58_51050 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FNV58_51075 ENOG4108KPJ rna polymerase sigma factor FNV58_51095 ENOG4108KXV response regulator FNV58_51135 ENOG4105C7W Xanthine dehydrogenase FNV58_51160 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_51185 ENOG4105BZU Histidine kinase FNV58_51195 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FNV58_51210 ENOG4105MP0 transposase FNV58_51245 ENOG4107YZX Universal stress protein FNV58_51250 ENOG4105CSR polyphosphate kinase 2 FNV58_51255 ENOG4107QRI Phosphoketolase FNV58_51260 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FNV58_51280 ENOG4105CD5 CoA-binding domain protein FNV58_51305 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FNV58_51320 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FNV58_51360 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FNV58_51380 ENOG4105CJW magnesium transporter FNV58_51425 ENOG41068KF Universal stress protein FNV58_51440 ENOG4105E2A Dehydrogenase FNV58_51455 ENOG4105D5Q Arginine ornithine antiporter FNV58_51460 ENOG4105CEU Arginine dihydrolase FNV58_51465 ENOG4105DBV ornithine carbamoyltransferase FNV58_51480 ENOG4105F1A Pyruvate formate-lyase FNV58_51515 ENOG4105E1F short-chain dehydrogenase reductase FNV58_51530 ENOG4105VEQ Cold shock protein FNV58_51535 ENOG4105C1J atp-dependent rna helicase FNV58_51560 ENOG4107SCK Monooxygenase FNV58_51585 ENOG4108JJA ABC, transporter FNV58_51620 ENOG4105D7V transposase FNV58_51630 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FNV58_51655 ENOG4105VUF Transcriptional regulator FNV58_51685 ENOG4105BZ1 (ABC) transporter FNV58_51720 ENOG4107RDT Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FNV58_51725 ENOG4107HP6 Transcriptional regulator FNV58_51735 ENOG4105CYP glycoside hydrolase, family FNV58_51740 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FNV58_51745 ENOG4105HSS phospholipase C FNV58_51770 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FNV58_51775 ENOG4105CHJ isochorismatase hydrolase FNV58_51805 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein FNV58_51870 ENOG4108MJI response regulator FNV58_51880 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FNV58_51885 ENOG41066YJ Beta-lactamase FNV58_51915 ENOG4105CHR reductase FNV58_51920 ENOG4105SKE transcriptional Regulator LysR family FNV58_51925 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FNV58_51960 ENOG4105EZR dyp-type peroxidase family protein FNV58_51970 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FNV58_51985 ENOG4105CF7 AraC family transcriptional regulator FNV58_51995 ENOG4108KXV response regulator FNV58_52000 ENOG41065SU Two-component system sensor kinase FNV58_52035 ENOG4108MP6 LysR family Transcriptional regulator FNV58_52095 ENOG41061H0 Monooxygenase FNV58_52100 ENOG4108IND Tetr family transcriptional regulator FNV58_52120 ENOG4105DQ4 alcohol dehydrogenase FNV58_52135 ENOG4105CNN ABC, transporter FNV58_52140 ENOG4105C2J ABC transporter FNV58_52150 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FNV58_52160 ENOG4105ETE Transcriptional regulator (LacI family FNV58_52165 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FNV58_52185 ENOG4107QN2 dihydrolipoyl dehydrogenase FNV58_52205 ENOG4105CHR reductase FNV58_52210 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FNV58_52240 ENOG4105C5X domain protein FNV58_52255 ENOG4105F7P transcriptional regulator AsnC family FNV58_52300 ENOG4105EUB pirin domain protein FNV58_52305 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FNV58_52330 ENOG4105EMN RNA polymerase sigma factor FNV58_52360 ENOG4105D74 hydrolase FNV58_52375 ENOG4105E5D amino acid FNV58_52385 ENOG4105E1F short-chain dehydrogenase reductase FNV58_52390 ENOG4107GJV short-chain dehydrogenase reductase FNV58_52415 ENOG4105CHP RNA polymerase FNV58_52420 ENOG4105GRZ Ycii-related protein FNV58_52465 ENOG4108JGH Tetr family transcriptional regulator FNV58_52470 ENOG4107S5I aldo keto reductase FNV58_52500 ENOG4106A3M Cytochrome p-450 FNV58_52525 ENOG4105BZU Histidine kinase FNV58_52530 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_52560 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_52565 ENOG4105BZU Histidine kinase FNV58_52570 ENOG4105HHS UPF0256 protein FNV58_52610 ENOG4108YIQ Alpha beta hydrolase FNV58_52630 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_52640 ENOG4105EMU Dehydrogenase FNV58_52645 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FNV58_52650 ENOG4105C26 Dehydrogenase FNV58_52655 ENOG4105C1B dTDP-glucose 4-6-dehydratase FNV58_52665 ENOG4105DEN Luciferase family FNV58_52670 ENOG4108IG5 Transcriptional regulator FNV58_52680 ENOG4107RSM transcriptional regulator FNV58_52685 ENOG4105FGE Short-chain dehydrogenase reductase Sdr FNV58_52705 ENOG4105ETX regulatoR FNV58_52805 ENOG4105XEA Tetr family transcriptional regulator FNV58_52815 ENOG4108JGH Tetr family transcriptional regulator FNV58_52880 ENOG4105C26 Dehydrogenase FNV58_52910 ENOG4105EE1 crotonyl-CoA reductase FNV58_52960 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FNV58_52970 ENOG4105EYF MMPL domain protein FNV58_52985 ENOG4105H3G oxidoreductase FNV58_52995 ENOG4105C26 Dehydrogenase FNV58_53000 ENOG4108ZX5 transcriptional regulator FNV58_53070 ENOG4105ECQ AraC Family Transcriptional Regulator FNV58_53080 ENOG4105C26 Dehydrogenase FNV58_53115 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV58_53135 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FNV58_53140 ENOG4105EJ2 Transcriptional regulator FNV58_53155 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FNV58_53160 ENOG4105EMU Dehydrogenase FNV58_53185 ENOG4105C57 major facilitator superfamily FNV58_53190 ENOG4105C57 major facilitator superfamily FNV58_53210 ENOG4105ETE Transcriptional regulator (LacI family FNV58_53235 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FNV58_53240 ENOG4105CPC Aldo Keto reductase FNV58_53275 ENOG4108W6C Dehydrogenase FNV58_53285 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FNV58_53310 ENOG4108WYP Transcriptional regulator FNV58_53315 ENOG4105BZU Histidine kinase FNV58_53320 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV58_53325 ENOG4105EYF MMPL domain protein FNV58_53410 ENOG4105Y3U Transglycosylase-associated protein FNV58_53415 ENOG41082SX arsR family transcriptional regulator FNV58_53425 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FNV58_53495 ENOG4105ERH Fumarylacetoacetate hydrolase FNV58_53510 ENOG41061H0 Monooxygenase FNV58_53530 ENOG4105D2S major facilitator superfamily FNV58_53535 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FNV58_53635 ENOG4105ECQ AraC Family Transcriptional Regulator FNV58_53675 ENOG4107SVN transposase FNV58_53685 ENOG4107SVN transposase FNV58_53690 ENOG4105BZU Histidine kinase FNV58_53695 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_53705 ENOG4105EBR Carboxylesterase FNV58_53895 ENOG4105EDW glycosyl transferase, family 39 FNV58_53965 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FNV58_54035 ENOG4105BZU Histidine kinase FNV58_54060 ENOG4108RAV Conserved protein FNV58_54070 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FNV58_54225 ENOG4108XXK NUDIX hydrolase FNV58_54270 ENOG4105K63 Thioredoxin FNV58_54295 ENOG4105C6Y Udp-glucose 6-dehydrogenase FNV58_54320 ENOG4105MWK D-amino acid dehydrogenase, small subunit FNV58_54325 ENOG4105ECY inositol monophosphatase FNV58_54330 ENOG4105G2Y Transcriptional regulator FNV58_54340 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FNV58_54380 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FNV58_54420 ENOG4105KHM amidohydrolase 2 FNV58_54445 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV58_54490 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_54495 ENOG4105BZU Histidine kinase FNV58_54585 ENOG4106IJN integrase catalytic domain-containing protein FNV58_54590 ENOG4105F5W AtP-binding protein FNV58_54650 ENOG41064MX Tetr family transcriptional regulator FNV58_54655 ENOG4108IG5 Transcriptional regulator FNV58_54705 ENOG4105D8K carboxyl transferase FNV58_54715 ENOG4105D7V transposase FNV58_54725 ENOG4107SQU synthase FNV58_54745 ENOG4105CEY Amp-dependent synthetase and ligase FNV58_54750 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_54775 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FNV58_54780 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FNV58_54785 ENOG4105CHR reductase FNV58_54790 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FNV58_54800 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FNV58_54805 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FNV58_54815 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FNV58_54825 ENOG4105CPC Aldo Keto reductase FNV58_54840 ENOG4108IQE Amp-dependent synthetase and ligase FNV58_54870 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FNV58_54925 ENOG4107V9E glucose-1-phosphate thymidylyltransferase FNV58_54945 ENOG4105D7V transposase FNV58_54960 ENOG4105CHJ isochorismatase hydrolase FNV58_54965 ENOG4105XPP Protein of unknown function (DUF1275) FNV58_55005 ENOG41085W3 Transposase FNV58_55050 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FNV58_55070 ENOG4105C9B Cysteine desulfurase FNV58_55100 ENOG4105D7V transposase FNV58_55135 ENOG4105BZP glycoside hydrolase 15-related FNV58_55140 ENOG410836F Transposase FNV58_55145 ENOG4105WH1 Two component transcriptional regulator luxr family FNV58_55150 ENOG4105BZU Histidine kinase FNV58_55180 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FNV58_55185 ENOG4108KPJ rna polymerase sigma factor FNV58_55250 ENOG4107R33 ppx gppa phosphatase FNV58_55360 ENOG4105EE1 crotonyl-CoA reductase FNV58_55435 ENOG4105ECQ AraC Family Transcriptional Regulator FNV58_55500 ENOG4105E7U AraC family transcriptional regulator FNV58_55525 ENOG4105F9F transposase FNV58_55665 ENOG4108KC1 acyl-Coa dehydrogenase FNV58_55670 ENOG4107RQ0 Maleylacetate reductase FNV58_55685 ENOG4107RSM transcriptional regulator FNV58_55690 ENOG4105CHU acetyl-coa acetyltransferase FNV58_55700 ENOG4107QNJ CoA-transferase subunit B FNV58_55715 ENOG4105H1N peptidase, M24 FNV58_55720 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FNV58_55730 ENOG4105D7V transposase FNV58_55735 ENOG4105ETE Transcriptional regulator (LacI family FNV58_55740 ENOG4105FDP GntR family transcriptional regulator FNV58_55750 ENOG4108JYK Dehydrogenase FNV58_55770 ENOG4105KNA -acetyltransferase FNV58_55780 ENOG4105ETE Transcriptional regulator (LacI family FNV58_55800 ENOG4105C0Z ABC transporter FNV58_55805 ENOG4105CJ1 ABC, transporter FNV58_55815 ENOG4105C32 Amino acid ABC transporter (Permease) FNV58_55830 ENOG4105CHJ isochorismatase hydrolase FNV58_55835 ENOG4105XPP Protein of unknown function (DUF1275) FNV58_55870 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FNV58_55880 ENOG4105D7T ABC transporter FNV58_55890 ENOG4108YYC ycei family FNV58_55895 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FNV58_55940 ENOG4105KF0 sporulation and cell division protein, SsgA FNV58_55970 ENOG4105KF0 sporulation and cell division protein, SsgA FNV58_56005 ENOG4105CBC glutamate synthase FNV58_56070 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FNV58_56075 ENOG4105CHR reductase FNV58_56095 ENOG4105CSH Transporter FNV58_56105 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F