locus-tag	class	description
GQS52_00110	COG3795	YCII-related domain
GQS52_00115	COG4941	Belongs to the sigma-70 factor family
GQS52_00120	COG4977	sequence-specific DNA binding
GQS52_00195	COG2814	Major facilitator Superfamily
GQS52_00215	COG1309	transcriptional regulator
GQS52_00220	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_00225	COG1802	Transcriptional regulator
GQS52_00230	COG0697	spore germination
GQS52_00320	COG2249	NAD(P)H dehydrogenase (quinone) activity
GQS52_00325	COG2838	Isocitrate dehydrogenase
GQS52_00345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GQS52_00350	COG1216	Glycosyl transferase, family 2
GQS52_00365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GQS52_00400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GQS52_00450	COG0596	Alpha beta hydrolase
GQS52_00465	COG1592	Rubrerythrin
GQS52_00470	COG2308	Evidence 4 Homologs of previously reported genes of
GQS52_00470	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GQS52_00500	COG0318	PFAM AMP-dependent synthetase and ligase
GQS52_00545	COG0446	pyridine nucleotide-disulphide oxidoreductase
GQS52_00545	COG1902	pentaerythritol trinitrate reductase activity
GQS52_00625	COG0437	4 iron, 4 sulfur cluster binding
GQS52_00630	COG0243	molybdopterin cofactor binding
GQS52_00630	COG3383	formate dehydrogenase (NAD+) activity
GQS52_00635	COG3012	SEC-C Motif Domain Protein
GQS52_00650	COG5002	protein histidine kinase activity
GQS52_00650	COG2205	protein histidine kinase activity
GQS52_00650	COG0784	Response regulator, receiver
GQS52_00690	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GQS52_00730	COG1653	transport
GQS52_00780	COG2259	Doxx family
GQS52_00810	COG2514	catechol 2,3-dioxygenase activity
GQS52_00815	COG0475	glutathione-regulated potassium exporter activity
GQS52_00825	COG0475	glutathione-regulated potassium exporter activity
GQS52_00835	COG1960	acyl-CoA dehydrogenase activity
GQS52_00845	COG0242	peptide deformylase activity
GQS52_00855	COG3442	glutamine amidotransferase
GQS52_00860	COG0205	6-phosphofructokinase activity
GQS52_00890	COG0740	serine-type endopeptidase activity
GQS52_00910	COG0156	8-amino-7-oxononanoate synthase activity
GQS52_00915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GQS52_00925	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GQS52_00930	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GQS52_00960	COG0488	(ABC) transporter
GQS52_00965	COG0586	Pfam SNARE associated Golgi protein
GQS52_00980	COG3663	DNA glycosylase
GQS52_00985	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GQS52_00995	COG2188	Transcriptional regulator
GQS52_01000	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_01005	COG0477	Major facilitator Superfamily
GQS52_01020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GQS52_01025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GQS52_01030	COG0508	dehydrogenase complex catalyzes the overall conversion of
GQS52_01030	COG0596	Alpha beta hydrolase
GQS52_01035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GQS52_01040	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GQS52_01045	COG2080	2 iron, 2 sulfur cluster binding
GQS52_01070	COG2814	Major facilitator Superfamily
GQS52_01115	COG0583	DNA-binding transcription factor activity
GQS52_01130	COG0419	ATPase involved in DNA repair
GQS52_01135	COG0420	3'-5' exonuclease activity
GQS52_01165	COG1832	CoA-binding protein
GQS52_01170	COG2267	carboxylic ester hydrolase activity
GQS52_01185	COG2223	nitrite transmembrane transporter activity
GQS52_01190	COG0110	maltose O-acetyltransferase activity
GQS52_01205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GQS52_01235	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GQS52_01240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GQS52_01270	COG0477	Major facilitator Superfamily
GQS52_01275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GQS52_01280	COG1968	undecaprenyl-diphosphatase activity
GQS52_01285	COG0183	Belongs to the thiolase family
GQS52_01290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GQS52_01300	COG0179	Fumarylacetoacetate (FAA) hydrolase
GQS52_01315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GQS52_01330	COG1136	(ABC) transporter
GQS52_01330	COG0577	efflux transmembrane transporter activity
GQS52_01350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GQS52_01365	COG0697	spore germination
GQS52_01370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GQS52_01380	COG0110	maltose O-acetyltransferase activity
GQS52_01385	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GQS52_01435	COG0529	Catalyzes the synthesis of activated sulfate
GQS52_01490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GQS52_01505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GQS52_01510	COG0542	response to heat
GQS52_01550	COG1132	(ABC) transporter
GQS52_01585	COG1309	transcriptional regulator
GQS52_01695	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GQS52_01710	COG2318	DinB family
GQS52_01715	COG2378	regulation of single-species biofilm formation
GQS52_01725	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GQS52_01775	COG0006	proline dipeptidase activity
GQS52_01780	COG0006	proline dipeptidase activity
GQS52_01795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GQS52_01800	COG0601	transmembrane transport
GQS52_01815	COG3291	Pkd domain containing protein
GQS52_01825	COG3938	Belongs to the proline racemase family
GQS52_01830	COG3938	Belongs to the proline racemase family
GQS52_01835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GQS52_01845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GQS52_01845	COG0446	pyridine nucleotide-disulphide oxidoreductase
GQS52_01850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GQS52_01880	COG0697	spore germination
GQS52_01895	COG0697	spore germination
GQS52_01905	COG0259	pyridoxamine-phosphate oxidase activity
GQS52_01910	COG0384	phenazine biosynthesis protein PhzF
GQS52_01935	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GQS52_01935	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GQS52_02020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GQS52_02030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GQS52_02035	COG1501	Belongs to the glycosyl hydrolase 31 family
GQS52_02040	COG2816	NAD+ diphosphatase activity
GQS52_02045	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GQS52_02060	COG2018	Roadblock/LC7 domain
GQS52_02090	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GQS52_02095	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GQS52_02100	COG1984	allophanate hydrolase subunit 2
GQS52_02140	COG0589	response to stress
GQS52_02170	COG0589	response to stress
GQS52_02190	COG0640	Transcriptional regulator
GQS52_02200	COG0492	ferredoxin-NADP+ reductase activity
GQS52_02205	COG2072	flavoprotein involved in K transport
GQS52_02210	COG0798	PFAM Bile acid sodium symporter
GQS52_02220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GQS52_02225	COG0492	ferredoxin-NADP+ reductase activity
GQS52_02235	COG1518	maintenance of DNA repeat elements
GQS52_02250	COG1857	crispr-associated protein
GQS52_02270	COG2376	Dihydroxyacetone kinase
GQS52_02275	COG1461	Dihydroxyacetone kinase
GQS52_02280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GQS52_02280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GQS52_02280	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GQS52_02315	COG1024	Enoyl-CoA hydratase
GQS52_02320	COG0318	PFAM AMP-dependent synthetase and ligase
GQS52_02370	COG0633	Ferredoxin
GQS52_02370	COG3217	Mosc domain protein beta barrel domain protein
GQS52_02390	COG1349	DNA-binding transcription factor activity
GQS52_02420	COG1846	Transcriptional regulator
GQS52_02445	COG1940	carbohydrate kinase activity
GQS52_02465	COG1846	Transcriptional regulator
GQS52_02470	COG2409	Drug exporters of the RND superfamily
GQS52_02480	COG2826	transposase and inactivated derivatives, IS30 family
GQS52_02500	COG0445	tRNA wobble uridine modification
GQS52_02505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GQS52_02510	COG1605	Chorismate mutase
GQS52_02510	COG0287	Prephenate dehydrogenase
GQS52_02515	COG2124	cytochrome p450
GQS52_02515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GQS52_02525	COG3458	cephalosporin-C deacetylase activity
GQS52_02535	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GQS52_02575	COG0584	glycerophosphoryl diester phosphodiesterase
GQS52_02600	COG0671	phosphoesterase, PA-phosphatase related
GQS52_02605	COG0584	glycerophosphoryl diester phosphodiesterase
GQS52_02630	COG0640	Transcriptional regulator
GQS52_02635	COG1902	pentaerythritol trinitrate reductase activity
GQS52_02645	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GQS52_02655	COG2971	BadF BadG BcrA BcrD
GQS52_02675	COG1522	sequence-specific DNA binding
GQS52_02680	COG1063	alcohol dehydrogenase
GQS52_02685	COG0432	Pfam Uncharacterised protein family UPF0047
GQS52_02695	COG1609	Transcriptional regulator
GQS52_02705	COG0523	cobalamin synthesis protein
GQS52_02745	COG1132	(ABC) transporter
GQS52_02755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GQS52_02815	COG2018	Roadblock/LC7 domain
GQS52_02835	COG3360	Dodecin
GQS52_02850	COG0446	pyridine nucleotide-disulphide oxidoreductase
GQS52_02895	COG3467	pyridoxamine 5'-phosphate
GQS52_02900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GQS52_02950	COG2183	response to ionizing radiation
GQS52_03000	COG3634	alkyl hydroperoxide reductase activity
GQS52_03100	COG2223	nitrite transmembrane transporter activity
GQS52_03115	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_03120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GQS52_03150	COG2356	endonuclease I
GQS52_03160	COG0583	DNA-binding transcription factor activity
GQS52_03180	COG2755	lipolytic protein G-D-S-L family
GQS52_03205	COG0326	Molecular chaperone. Has ATPase activity
GQS52_03215	COG2226	methyltransferase
GQS52_03270	COG4977	sequence-specific DNA binding
GQS52_03355	COG1819	glycosyl
GQS52_03405	COG0179	Fumarylacetoacetate (FAA) hydrolase
GQS52_03410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GQS52_03415	COG1012	belongs to the aldehyde dehydrogenase family
GQS52_03470	COG3209	COG3209 Rhs family protein
GQS52_03520	COG2197	response regulator
GQS52_03540	COG3959	Transketolase, thiamine diphosphate binding domain
GQS52_03545	COG3958	Transketolase
GQS52_03565	COG2018	Roadblock/LC7 domain
GQS52_03600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GQS52_03670	COG2345	Transcriptional regulator
GQS52_03700	COG3959	Transketolase, thiamine diphosphate binding domain
GQS52_03730	COG2365	Tyrosine phosphatase family
GQS52_03750	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GQS52_03760	COG1562	ergosterol biosynthetic process
GQS52_03765	COG1134	teichoic acid transport
GQS52_03810	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GQS52_03815	COG1024	Enoyl-CoA hydratase
GQS52_03955	COG1222	aaa ATPase
GQS52_04000	COG0626	cystathionine gamma-synthase activity
GQS52_04005	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GQS52_04010	COG0488	(ABC) transporter
GQS52_04050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GQS52_04055	COG1960	acyl-CoA dehydrogenase activity
GQS52_04060	COG0183	Belongs to the thiolase family
GQS52_04065	COG1250	3-hydroxyacyl-CoA dehydrogenase
GQS52_04065	COG1024	Enoyl-CoA hydratase
GQS52_04135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GQS52_04165	COG4932	domain protein
GQS52_04165	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GQS52_04165	COG3266	domain, Protein
GQS52_04205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GQS52_04220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GQS52_04230	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_04270	COG0443	Heat shock 70 kDa protein
GQS52_04275	COG0071	Belongs to the small heat shock protein (HSP20) family
GQS52_04305	COG2843	Capsule synthesis protein
GQS52_04320	COG0515	serine threonine protein kinase
GQS52_04320	COG2815	serine threonine protein kinase
GQS52_04325	COG1472	Belongs to the glycosyl hydrolase 3 family
GQS52_04330	COG3876	Protein conserved in bacteria
GQS52_04335	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GQS52_04375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GQS52_04380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GQS52_04420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GQS52_04420	COG1017	nitric oxide dioxygenase activity
GQS52_04425	COG1959	2 iron, 2 sulfur cluster binding
GQS52_04450	COG1733	regulation of RNA biosynthetic process
GQS52_04455	COG2084	Dehydrogenase
GQS52_04465	COG0534	Mate efflux family protein
GQS52_04495	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GQS52_04500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GQS52_04575	COG1404	Belongs to the peptidase S8 family
GQS52_04590	COG1404	Belongs to the peptidase S8 family
GQS52_04710	COG2815	serine threonine protein kinase
GQS52_04710	COG0515	serine threonine protein kinase
GQS52_04775	COG0656	L-ascorbic acid biosynthetic process
GQS52_04800	COG0477	Major facilitator Superfamily
GQS52_04845	COG2770	Histidine kinase
GQS52_04845	COG2208	phosphoserine phosphatase activity
GQS52_04850	COG1366	Belongs to the anti-sigma-factor antagonist family
GQS52_04855	COG2382	esterase
GQS52_04885	COG1960	acyl-CoA dehydrogenase activity
GQS52_04905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GQS52_04955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GQS52_04970	COG3629	intracellular signal transduction
GQS52_04980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GQS52_04990	COG2271	Major facilitator Superfamily
GQS52_05005	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GQS52_05030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GQS52_05030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GQS52_05035	COG3433	isochorismatase activity
GQS52_05035	COG1535	isochorismatase
GQS52_05040	COG1021	2,3-dihydroxybenzoate-AMP ligase
GQS52_05045	COG1169	isochorismate synthase
GQS52_05050	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_05060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GQS52_05100	COG0583	DNA-binding transcription factor activity
GQS52_05105	COG1960	acyl-CoA dehydrogenase activity
GQS52_05115	COG1619	proteins homologs of microcin C7 resistance protein MccF
GQS52_05125	COG4946	Tricorn protease homolog
GQS52_05125	COG1506	peptidase
GQS52_05125	COG0823	Involved in the tonB-independent uptake of proteins
GQS52_05130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GQS52_05135	COG2362	D-Aminopeptidase
GQS52_05165	COG1366	Belongs to the anti-sigma-factor antagonist family
GQS52_05170	COG1366	Belongs to the anti-sigma-factor antagonist family
GQS52_05175	COG2172	sigma factor antagonist activity
GQS52_05185	COG1250	3-hydroxyacyl-CoA dehydrogenase
GQS52_05200	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GQS52_05200	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GQS52_05210	COG1960	acyl-CoA dehydrogenase activity
GQS52_05215	COG0688	phosphatidylethanolamine metabolic process
GQS52_05225	COG1929	Belongs to the glycerate kinase type-1 family
GQS52_05230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GQS52_05235	COG1278	Cold shock
GQS52_05240	COG0598	Magnesium transport protein CorA
GQS52_05250	COG0483	inositol monophosphate 1-phosphatase activity
GQS52_05255	COG0405	Gamma-glutamyltransferase
GQS52_05265	COG2936	dipeptidyl-peptidase activity
GQS52_05315	COG0708	Exodeoxyribonuclease III
GQS52_05325	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GQS52_05330	COG0477	Major facilitator Superfamily
GQS52_05340	COG2267	carboxylic ester hydrolase activity
GQS52_05345	COG3971	2-oxopent-4-enoate hydratase activity
GQS52_05365	COG1309	transcriptional regulator
GQS52_05370	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_05380	COG1940	carbohydrate kinase activity
GQS52_05385	COG1129	ABC transporter
GQS52_05400	COG1082	Xylose isomerase domain protein TIM barrel
GQS52_05410	COG0800	Aldolase
GQS52_05415	COG1414	Transcriptional regulator
GQS52_05440	COG0259	pyridoxamine-phosphate oxidase activity
GQS52_05465	COG0318	PFAM AMP-dependent synthetase and ligase
GQS52_05470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GQS52_05475	COG2197	response regulator
GQS52_05485	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GQS52_05495	COG1773	rubredoxin
GQS52_05500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GQS52_05525	COG3608	succinylglutamate desuccinylase aspartoacylase
GQS52_05525	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GQS52_05570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GQS52_05575	COG1162	GTPase activity
GQS52_05585	COG1960	acyl-CoA dehydrogenase activity
GQS52_05590	COG3284	Transcriptional regulator
GQS52_05600	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GQS52_05610	COG0175	sulfate reduction
GQS52_05615	COG0529	Catalyzes the synthesis of activated sulfate
GQS52_05640	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GQS52_05645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GQS52_05700	COG0515	serine threonine protein kinase
GQS52_05700	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GQS52_05710	COG3226	Transcriptional regulator
GQS52_05715	COG0154	amidase activity
GQS52_05775	COG2197	response regulator
GQS52_05780	COG4585	Histidine kinase
GQS52_05790	COG0702	epimerase
GQS52_05820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GQS52_05835	COG3220	belongs to the UPF0276 family
GQS52_05840	COG3220	belongs to the UPF0276 family
GQS52_05860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GQS52_05880	COG0183	Belongs to the thiolase family
GQS52_05885	COG1250	3-hydroxyacyl-CoA dehydrogenase
GQS52_05885	COG1024	Enoyl-CoA hydratase
GQS52_05910	COG0531	amino acid
GQS52_05915	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GQS52_05920	COG4214	carbohydrate transport
GQS52_05930	COG4213	ABC transporter substrate-binding protein
GQS52_05935	COG1940	carbohydrate kinase activity
GQS52_05940	COG0395	ABC-type sugar transport system, permease component
GQS52_05945	COG1175	transmembrane transport
GQS52_05950	COG1653	transport
GQS52_05955	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GQS52_05960	COG0531	amino acid
GQS52_05965	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GQS52_05975	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GQS52_05990	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GQS52_05995	COG0121	glutamine amidotransferase
GQS52_06000	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GQS52_06005	COG3572	ergothioneine biosynthetic process
GQS52_06025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GQS52_06040	COG3654	unkown
GQS52_06085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GQS52_06095	COG0531	amino acid
GQS52_06100	COG0569	domain protein
GQS52_06135	COG0756	dUTP diphosphatase activity
GQS52_06145	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_06160	COG2205	protein histidine kinase activity
GQS52_06165	COG0745	RESPONSE REGULATOR receiver
GQS52_06170	COG0483	inositol monophosphate 1-phosphatase activity
GQS52_06205	COG1435	thymidine kinase activity
GQS52_06225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GQS52_06230	COG1802	Transcriptional regulator
GQS52_06240	COG0612	Peptidase, M16
GQS52_06245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GQS52_06260	COG0187	DNA topoisomerase II activity
GQS52_06275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GQS52_06280	COG2186	Transcriptional regulator
GQS52_06315	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GQS52_06360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GQS52_06385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GQS52_06390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GQS52_06395	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GQS52_06405	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GQS52_06420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GQS52_06425	COG2358	TRAP transporter, solute receptor (TAXI family
GQS52_06430	COG0515	serine threonine protein kinase
GQS52_06435	COG2205	protein histidine kinase activity
GQS52_06440	COG0745	RESPONSE REGULATOR receiver
GQS52_06445	COG1126	abc transporter atp-binding protein
GQS52_06455	COG0765	amino acid transport
GQS52_06460	COG0765	amino acid transport
GQS52_06470	COG1418	mRNA catabolic process
GQS52_06470	COG1566	PFAM secretion protein HlyD family protein
GQS52_06480	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GQS52_06485	COG0628	permease
GQS52_06510	COG1201	RNA secondary structure unwinding
GQS52_06520	COG0783	Belongs to the Dps family
GQS52_06525	COG1396	sequence-specific DNA binding
GQS52_06530	COG1058	Belongs to the CinA family
GQS52_06530	COG1546	Belongs to the CinA family
GQS52_06540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GQS52_06550	COG1674	ftsk spoiiie
GQS52_06560	COG2205	protein histidine kinase activity
GQS52_06560	COG0784	Response regulator, receiver
GQS52_06565	COG2770	Histidine kinase
GQS52_06565	COG2208	phosphoserine phosphatase activity
GQS52_06575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GQS52_06595	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GQS52_06600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GQS52_06605	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GQS52_06625	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GQS52_06630	COG0612	Peptidase, M16
GQS52_06635	COG1185	polyribonucleotide nucleotidyltransferase activity
GQS52_06640	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GQS52_06650	COG1674	ftsk spoiiie
GQS52_06670	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GQS52_06670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GQS52_06690	COG1404	Belongs to the peptidase S8 family
GQS52_06710	COG1404	Belongs to the peptidase S8 family
GQS52_06725	COG3266	domain, Protein
GQS52_06740	COG0455	bacterial-type flagellum organization
GQS52_06750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GQS52_06760	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GQS52_06770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GQS52_06785	COG0779	Required for maturation of 30S ribosomal subunits
GQS52_06800	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
GQS52_06810	COG0442	prolyl-tRNA aminoacylation
GQS52_06825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GQS52_06830	COG0750	zinc metalloprotease
GQS52_06835	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GQS52_06840	COG1595	DNA-templated transcription, initiation
GQS52_06850	COG1012	belongs to the aldehyde dehydrogenase family
GQS52_06855	COG2508	Transcriptional regulator
GQS52_06875	COG2318	DinB family
GQS52_06885	COG2072	flavoprotein involved in K transport
GQS52_06890	COG1177	transmembrane transport
GQS52_06895	COG1176	ABC-type spermidine putrescine transport system, permease component I
GQS52_06900	COG3842	ATPase activity
GQS52_06930	COG1404	Belongs to the peptidase S8 family
GQS52_06940	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GQS52_06945	COG1012	belongs to the aldehyde dehydrogenase family
GQS52_06955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GQS52_06970	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GQS52_06975	COG1122	ATPase activity
GQS52_06980	COG4721	ABC-type cobalt transport system, permease component
GQS52_06985	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GQS52_06990	COG0575	Belongs to the CDS family
GQS52_06995	COG0233	cytoplasmic translational termination
GQS52_07000	COG0528	UMP kinase activity
GQS52_07005	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GQS52_07010	COG0052	Belongs to the universal ribosomal protein uS2 family
GQS52_07025	COG1191	sigma factor activity
GQS52_07040	COG0792	nuclease activity
GQS52_07050	COG1051	belongs to the nudix hydrolase family
GQS52_07055	COG0681	Belongs to the peptidase S26 family
GQS52_07060	COG0681	Belongs to the peptidase S26 family
GQS52_07065	COG0681	Belongs to the peptidase S26 family
GQS52_07075	COG0335	large ribosomal subunit rRNA binding
GQS52_07080	COG0336	Belongs to the RNA methyltransferase TrmD family
GQS52_07085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GQS52_07090	COG1837	Belongs to the UPF0109 family
GQS52_07095	COG0228	four-way junction DNA binding
GQS52_07120	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GQS52_07155	COG1072	(Pantothenic acid kinase))
GQS52_07160	COG0477	Major facilitator Superfamily
GQS52_07165	COG1196	nuclear chromosome segregation
GQS52_07175	COG1254	Belongs to the acylphosphatase family
GQS52_07180	COG2340	Cysteine-rich secretory protein family
GQS52_07190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GQS52_07200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GQS52_07215	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GQS52_07220	COG0742	ribosomal rna small subunit methyltransferase
GQS52_07230	COG1461	Dihydroxyacetone kinase
GQS52_07235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GQS52_07240	COG0351	phosphomethylpyrimidine kinase
GQS52_07260	COG1181	Belongs to the D-alanine--D-alanine ligase family
GQS52_07265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GQS52_07275	COG1920	GTP binding
GQS52_07280	COG0776	regulation of translation
GQS52_07290	COG0066	3-isopropylmalate dehydratase activity
GQS52_07295	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GQS52_07300	COG1414	Transcriptional regulator
GQS52_07340	COG0179	Fumarylacetoacetate (FAA) hydrolase
GQS52_07350	COG0642	Histidine kinase
GQS52_07355	COG2018	Roadblock/LC7 domain
GQS52_07375	COG2018	Roadblock/LC7 domain
GQS52_07395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GQS52_07400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GQS52_07405	COG0473	3-isopropylmalate dehydrogenase activity
GQS52_07420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GQS52_07425	COG0440	acetolactate synthase activity
GQS52_07445	COG0667	Aldo Keto reductase
GQS52_07470	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GQS52_07485	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GQS52_07495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GQS52_07505	COG4221	oxidoreductase activity
GQS52_07510	COG0482	sulfurtransferase activity
GQS52_07535	COG3540	Alkaline phosphatase
GQS52_07540	COG2860	membrane
GQS52_07545	COG4608	Belongs to the ABC transporter superfamily
GQS52_07550	COG0444	Belongs to the ABC transporter superfamily
GQS52_07560	COG4166	transmembrane transport
GQS52_07595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GQS52_07600	COG0509	glycine decarboxylation via glycine cleavage system
GQS52_07605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GQS52_07610	COG1760	l-serine dehydratase
GQS52_07615	COG0569	domain protein
GQS52_07620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GQS52_07675	COG1024	Enoyl-CoA hydratase
GQS52_07690	COG1132	(ABC) transporter
GQS52_07695	COG1132	(ABC) transporter
GQS52_07705	COG0058	SHG alpha-glucan phosphorylase activity
GQS52_07710	COG0366	Alpha amylase catalytic
GQS52_07725	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GQS52_07730	COG1301	dicarboxylic acid transport
GQS52_07740	COG4565	transcriptional regulatory protein
GQS52_07745	COG0205	6-phosphofructokinase activity
GQS52_07750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GQS52_07755	COG0857	belongs to the CobB CobQ family
GQS52_07755	COG0280	phosphate acetyltransferase
GQS52_07760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GQS52_07800	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GQS52_07800	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GQS52_07850	COG0183	Belongs to the thiolase family
GQS52_07870	COG1131	(ABC) transporter
GQS52_07895	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GQS52_07910	COG1250	3-hydroxyacyl-CoA dehydrogenase
GQS52_07925	COG4585	Histidine kinase
GQS52_07930	COG2197	response regulator
GQS52_07940	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GQS52_07945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GQS52_07950	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GQS52_07955	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GQS52_07960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GQS52_07965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GQS52_07975	COG0356	it plays a direct role in the translocation of protons across the membrane
GQS52_07990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GQS52_08005	COG2890	protein-(glutamine-N5) methyltransferase activity
GQS52_08010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GQS52_08015	COG0254	rRNA binding
GQS52_08020	COG1316	TRANSCRIPTIONal
GQS52_08030	COG0083	homoserine kinase activity
GQS52_08035	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GQS52_08040	COG0460	homoserine dehydrogenase
GQS52_08045	COG0019	diaminopimelate decarboxylase activity
GQS52_08050	COG0018	arginyl-trna synthetase
GQS52_08055	COG0745	RESPONSE REGULATOR receiver
GQS52_08070	COG0464	growth
GQS52_08095	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GQS52_08100	COG1733	regulation of RNA biosynthetic process
GQS52_08140	COG0768	penicillin binding
GQS52_08205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GQS52_08245	COG0745	RESPONSE REGULATOR receiver
GQS52_08250	COG2205	protein histidine kinase activity
GQS52_08255	COG0508	dehydrogenase complex catalyzes the overall conversion of
GQS52_08255	COG0567	Dehydrogenase, E1 component
GQS52_08265	COG0604	alcohol dehydrogenase
GQS52_08285	COG0281	malic enzyme
GQS52_08290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GQS52_08300	COG1126	abc transporter atp-binding protein
GQS52_08305	COG4106	trans-aconitate 2-methyltransferase activity
GQS52_08355	COG2124	cytochrome p450
GQS52_08380	COG5002	protein histidine kinase activity
GQS52_08400	COG0583	DNA-binding transcription factor activity
GQS52_08405	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GQS52_08430	COG1597	lipid kinase activity
GQS52_08445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GQS52_08450	COG1472	Belongs to the glycosyl hydrolase 3 family
GQS52_08455	COG0395	ABC-type sugar transport system, permease component
GQS52_08460	COG1175	transmembrane transport
GQS52_08470	COG2188	Transcriptional regulator
GQS52_08475	COG1966	Carbon starvation protein
GQS52_08495	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GQS52_08505	COG0242	peptide deformylase activity
GQS52_08515	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GQS52_08520	COG5662	AntiSigma factor
GQS52_08525	COG1595	DNA-templated transcription, initiation
GQS52_08535	COG2135	peptidase activity
GQS52_08545	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GQS52_08550	COG1162	GTPase activity
GQS52_08560	COG0483	inositol monophosphate 1-phosphatase activity
GQS52_08570	COG0753	catalase activity
GQS52_08595	COG1615	UPF0182 protein
GQS52_08605	COG3480	Lon protease (S16) C-terminal proteolytic domain
GQS52_08640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GQS52_08670	COG0483	inositol monophosphate 1-phosphatase activity
GQS52_08680	COG4106	trans-aconitate 2-methyltransferase activity
GQS52_08690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GQS52_08695	COG0210	DNA helicase
GQS52_08710	COG1088	dTDP-glucose 4,6-dehydratase activity
GQS52_08730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GQS52_08830	COG1432	Conserved Protein
GQS52_08835	COG2095	MarC family integral membrane protein
GQS52_08855	COG0598	Magnesium transport protein CorA
GQS52_08870	COG2239	Acts as a magnesium transporter
GQS52_08895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GQS52_08900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GQS52_08910	COG1595	DNA-templated transcription, initiation
GQS52_08925	COG1024	Enoyl-CoA hydratase
GQS52_08930	COG0519	Catalyzes the synthesis of GMP from XMP
GQS52_08950	COG1611	Belongs to the LOG family
GQS52_08955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GQS52_08990	COG1309	transcriptional regulator
GQS52_08995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GQS52_09010	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GQS52_09025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GQS52_09045	COG4608	Belongs to the ABC transporter superfamily
GQS52_09055	COG1105	Belongs to the carbohydrate kinase PfkB family
GQS52_09060	COG4608	Belongs to the ABC transporter superfamily
GQS52_09065	COG0444	Belongs to the ABC transporter superfamily
GQS52_09070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GQS52_09075	COG0601	transmembrane transport
GQS52_09080	COG4166	transmembrane transport
GQS52_09090	COG4608	Belongs to the ABC transporter superfamily
GQS52_09095	COG0444	Belongs to the ABC transporter superfamily
GQS52_09105	COG0601	transmembrane transport
GQS52_09110	COG4166	transmembrane transport
GQS52_09180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GQS52_09195	COG0012	GTP binding
GQS52_09210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GQS52_09215	COG1570	exodeoxyribonuclease VII activity
GQS52_09220	COG1722	exodeoxyribonuclease VII activity
GQS52_09245	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GQS52_09245	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GQS52_09250	COG0114	fumarate hydratase activity
GQS52_09260	COG2226	methyltransferase
GQS52_09305	COG0450	alkyl hydroperoxide reductase
GQS52_09310	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GQS52_09325	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GQS52_09330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GQS52_09335	COG0667	Aldo Keto reductase
GQS52_09380	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GQS52_09400	COG2885	chlorophyll binding
GQS52_09420	COG2197	response regulator
GQS52_09425	COG3920	Histidine kinase
GQS52_09450	COG2894	cell division
GQS52_09475	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GQS52_09485	COG1309	transcriptional regulator
GQS52_09515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GQS52_09525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GQS52_09540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GQS52_09570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GQS52_09580	COG2824	Alkylphosphonate utilization operon protein PhnA
GQS52_09585	COG0501	Belongs to the peptidase M48B family
GQS52_09615	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GQS52_09630	COG1404	Belongs to the peptidase S8 family
GQS52_09635	COG1940	carbohydrate kinase activity
GQS52_09650	COG1316	TRANSCRIPTIONal
GQS52_09685	COG2986	histidine ammonia-lyase
GQS52_09690	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GQS52_09700	COG1024	Enoyl-CoA hydratase
GQS52_09705	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GQS52_09715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GQS52_09725	COG0424	maF-like protein
GQS52_09735	COG0477	Major facilitator Superfamily
GQS52_09750	COG4770	biotin carboxylase activity
GQS52_09775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GQS52_09795	COG1012	belongs to the aldehyde dehydrogenase family
GQS52_09800	COG1012	belongs to the aldehyde dehydrogenase family
GQS52_09825	COG1595	DNA-templated transcription, initiation
GQS52_09830	COG0745	RESPONSE REGULATOR receiver
GQS52_09835	COG2205	protein histidine kinase activity
GQS52_09860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GQS52_09870	COG0583	DNA-binding transcription factor activity
GQS52_09875	COG2814	Major facilitator Superfamily
GQS52_09885	COG0745	RESPONSE REGULATOR receiver
GQS52_09890	COG5002	protein histidine kinase activity
GQS52_09940	COG1473	amidohydrolase
GQS52_09940	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GQS52_09965	COG2089	acid synthase
GQS52_09980	COG1216	Glycosyl transferase, family 2
GQS52_09995	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GQS52_09995	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GQS52_10005	COG1595	DNA-templated transcription, initiation
GQS52_10045	COG2009	succinate dehydrogenase
GQS52_10060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GQS52_10075	COG1408	metallophosphoesterase
GQS52_10100	COG0180	Tryptophanyl-tRNA synthetase
GQS52_10115	COG0477	Major facilitator Superfamily
GQS52_10120	COG0754	glutathionylspermidine amidase activity
GQS52_10140	COG0039	L-malate dehydrogenase activity
GQS52_10150	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GQS52_10165	COG0138	bifunctional purine biosynthesis protein purh
GQS52_10190	COG0045	succinate-CoA ligase (ADP-forming) activity
GQS52_10205	COG3552	Protein containing von Willebrand factor type A (VWA) domain
GQS52_10215	COG0714	Associated with various cellular activities
GQS52_10235	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GQS52_10235	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GQS52_10270	COG2197	response regulator
GQS52_10300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GQS52_10300	COG0519	Catalyzes the synthesis of GMP from XMP
GQS52_10360	COG5650	phosphatidylinositol metabolic process
GQS52_10365	COG3973	AAA domain
GQS52_10385	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GQS52_10395	COG1278	Cold shock
GQS52_10410	COG0463	Glycosyl transferase, family 2
GQS52_10435	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GQS52_10475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GQS52_10520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GQS52_10525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GQS52_10530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GQS52_10535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GQS52_10555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GQS52_10565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GQS52_10570	COG3251	PFAM MbtH domain protein
GQS52_10575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GQS52_10580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GQS52_10595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GQS52_10595	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GQS52_10660	COG2154	pterin-4-alpha-carbinolamine dehydratase
GQS52_10725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GQS52_10730	COG1522	sequence-specific DNA binding
GQS52_10735	COG1063	alcohol dehydrogenase
GQS52_10755	COG3842	ATPase activity
GQS52_10765	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GQS52_10775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GQS52_10780	COG0215	cysteine-tRNA ligase activity
GQS52_10785	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GQS52_10790	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GQS52_10795	COG1329	Transcriptional regulator
GQS52_10815	COG5002	protein histidine kinase activity
GQS52_10830	COG2826	transposase and inactivated derivatives, IS30 family
GQS52_10845	COG1129	ABC transporter
GQS52_10935	COG4974	Belongs to the 'phage' integrase family
GQS52_10940	COG0588	phosphoglycerate mutase activity
GQS52_10955	COG0438	transferase activity, transferring glycosyl groups
GQS52_10990	COG0583	DNA-binding transcription factor activity
GQS52_11010	COG1490	D-aminoacyl-tRNA deacylase activity
GQS52_11025	COG3485	protocatechuate 3,4-dioxygenase
GQS52_11065	COG2897	thiosulfate sulfurtransferase activity
GQS52_11090	COG0745	RESPONSE REGULATOR receiver
GQS52_11095	COG1609	Transcriptional regulator
GQS52_11100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GQS52_11105	COG0737	Belongs to the 5'-nucleotidase family
GQS52_11110	COG2271	Major facilitator Superfamily
GQS52_11115	COG0456	acetyltransferase
GQS52_11150	COG0306	phosphate transporter
GQS52_11160	COG1937	Protein conserved in bacteria
GQS52_11180	COG0671	phosphoesterase, PA-phosphatase related
GQS52_11185	COG0741	lytic transglycosylase activity
GQS52_11185	COG0739	heme binding
GQS52_11185	COG1196	nuclear chromosome segregation
GQS52_11220	COG0456	acetyltransferase
GQS52_11255	COG1252	NADH dehydrogenase
GQS52_11280	COG0579	oxidoreductase
GQS52_11295	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GQS52_11390	COG1742	UPF0060 membrane protein
GQS52_11395	COG0592	DNA-directed DNA polymerase activity
GQS52_11415	COG1196	nuclear chromosome segregation
GQS52_11415	COG0741	lytic transglycosylase activity
GQS52_11415	COG0739	heme binding
GQS52_11420	COG2814	Major facilitator Superfamily
GQS52_11455	COG1366	Belongs to the anti-sigma-factor antagonist family
GQS52_11465	COG0277	FAD linked oxidase domain protein
GQS52_11475	COG1733	regulation of RNA biosynthetic process
GQS52_11490	COG0513	Belongs to the DEAD box helicase family
GQS52_11500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GQS52_11505	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GQS52_11535	COG1643	Atp-dependent helicase
GQS52_11555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GQS52_11565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GQS52_11580	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GQS52_11585	COG0047	phosphoribosylformylglycinamidine synthase activity
GQS52_11590	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GQS52_11610	COG1131	(ABC) transporter
GQS52_11625	COG2197	response regulator
GQS52_11635	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GQS52_11650	COG0151	Belongs to the GarS family
GQS52_11675	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GQS52_11685	COG1131	(ABC) transporter
GQS52_11690	COG3559	Exporter of polyketide antibiotics
GQS52_11720	COG1396	sequence-specific DNA binding
GQS52_11725	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
GQS52_11730	COG1556	Lactate utilization protein
GQS52_11735	COG1139	Iron-sulfur cluster binding protein
GQS52_11740	COG0247	lactate metabolic process
GQS52_11745	COG1620	l-lactate permease
GQS52_11750	COG2186	Transcriptional regulator
GQS52_11755	COG2197	response regulator
GQS52_11760	COG4585	Histidine kinase
GQS52_11770	COG1695	Transcriptional regulator
GQS52_11785	COG0191	fructose-bisphosphate aldolase activity
GQS52_11790	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GQS52_11805	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GQS52_11840	COG0542	response to heat
GQS52_11865	COG0789	Transcriptional regulator
GQS52_11870	COG0484	heat shock protein binding
GQS52_11875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GQS52_11880	COG0443	Heat shock 70 kDa protein
GQS52_11885	COG0247	lactate metabolic process
GQS52_11885	COG2181	nitrate reductase activity
GQS52_11925	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_11975	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GQS52_11980	COG0717	Belongs to the dCTP deaminase family
GQS52_12005	COG0464	growth
GQS52_12125	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GQS52_12130	COG2124	cytochrome p450
GQS52_12135	COG1309	transcriptional regulator
GQS52_12155	COG1278	Cold shock
GQS52_12160	COG0513	Belongs to the DEAD box helicase family
GQS52_12165	COG0477	Major facilitator Superfamily
GQS52_12190	COG2197	response regulator
GQS52_12205	COG1131	(ABC) transporter
GQS52_12255	COG0577	efflux transmembrane transporter activity
GQS52_12255	COG1136	(ABC) transporter
GQS52_12320	COG2132	Multicopper oxidase
GQS52_12330	COG0659	secondary active sulfate transmembrane transporter activity
GQS52_12350	COG1741	Belongs to the pirin family
GQS52_12360	COG1960	acyl-CoA dehydrogenase activity
GQS52_12365	COG1362	aminopeptidase activity
GQS52_12370	COG3903	Transcriptional regulator
GQS52_12370	COG3629	intracellular signal transduction
GQS52_12405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GQS52_12415	COG0477	Major facilitator Superfamily
GQS52_12425	COG0508	dehydrogenase complex catalyzes the overall conversion of
GQS52_12430	COG0022	dehydrogenase e1 component
GQS52_12445	COG0515	serine threonine protein kinase
GQS52_12450	COG0515	serine threonine protein kinase
GQS52_12465	COG0604	alcohol dehydrogenase
GQS52_12465	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_12465	COG3321	synthase
GQS52_12470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GQS52_12500	COG1522	sequence-specific DNA binding
GQS52_12505	COG1309	transcriptional regulator
GQS52_12565	COG1716	ATPase activity
GQS52_12570	COG1716	ATPase activity
GQS52_12590	COG0515	serine threonine protein kinase
GQS52_12595	COG3764	Sortase (surface protein transpeptidase)
GQS52_12600	COG3764	Sortase (surface protein transpeptidase)
GQS52_12620	COG0457	Tetratricopeptide repeat
GQS52_12620	COG0705	Rhomboid family
GQS52_12645	COG0515	serine threonine protein kinase
GQS52_12675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GQS52_12685	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GQS52_12690	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GQS52_12695	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GQS52_12700	COG0592	DNA-directed DNA polymerase activity
GQS52_12710	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GQS52_12720	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GQS52_12725	COG0706	membrane insertase activity
GQS52_12735	COG0357	Ribosomal RNA small subunit methyltransferase G
GQS52_12740	COG1192	Involved in chromosome partitioning
GQS52_12755	COG3118	belongs to the thioredoxin family
GQS52_12760	COG0492	ferredoxin-NADP+ reductase activity
GQS52_12770	COG1595	DNA-templated transcription, initiation
GQS52_12790	COG0617	tRNA 3'-terminal CCA addition
GQS52_12805	COG1260	myo-inositol-1-phosphate synthase
GQS52_12815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GQS52_12840	COG0360	Binds together with S18 to 16S ribosomal RNA
GQS52_12845	COG0629	single-stranded DNA binding
GQS52_12850	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GQS52_12855	COG0359	binds to the 23S rRNA
GQS52_12860	COG0534	Mate efflux family protein
GQS52_12865	COG0305	Participates in initiation and elongation during chromosome replication
GQS52_12910	COG0626	cystathionine gamma-synthase activity
GQS52_12925	COG1950	PFAM Membrane protein of
GQS52_12930	COG0662	Cupin 2, conserved barrel domain protein
GQS52_12945	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GQS52_12975	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GQS52_12985	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GQS52_13000	COG1609	Transcriptional regulator
GQS52_13005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GQS52_13010	COG1271	oxidase subunit
GQS52_13015	COG1294	oxidase, subunit
GQS52_13020	COG4988	ABC transporter
GQS52_13025	COG0561	phosphatase activity
GQS52_13030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GQS52_13055	COG1131	(ABC) transporter
GQS52_13065	COG1131	(ABC) transporter
GQS52_13075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GQS52_13080	COG0561	phosphatase activity
GQS52_13085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GQS52_13095	COG2837	iron assimilation
GQS52_13100	COG2372	response to copper ion
GQS52_13100	COG1276	copper resistance
GQS52_13130	COG0006	proline dipeptidase activity
GQS52_13145	COG0653	protein targeting
GQS52_13160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GQS52_13185	COG1595	DNA-templated transcription, initiation
GQS52_13190	COG0318	PFAM AMP-dependent synthetase and ligase
GQS52_13195	COG5000	phosphorelay sensor kinase activity
GQS52_13215	COG3842	ATPase activity
GQS52_13220	COG1178	ABC-type Fe3 transport system permease component
GQS52_13225	COG1840	ABC-type Fe3 transport system, periplasmic component
GQS52_13230	COG2353	YceI-like domain
GQS52_13250	COG1191	sigma factor activity
GQS52_13255	COG1191	sigma factor activity
GQS52_13285	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GQS52_13330	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GQS52_13335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GQS52_13355	COG1595	DNA-templated transcription, initiation
GQS52_13445	COG1408	metallophosphoesterase
GQS52_13455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GQS52_13465	COG0003	Pfam Anion-transporting ATPase
GQS52_13595	COG1205	dead DEAH box helicase
GQS52_13595	COG1111	helicase
GQS52_13600	COG1366	Belongs to the anti-sigma-factor antagonist family
GQS52_13605	COG2172	sigma factor antagonist activity
GQS52_13610	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GQS52_13620	COG2890	protein-(glutamine-N5) methyltransferase activity
GQS52_13630	COG1754	DNA topoisomerase type I activity
GQS52_13630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GQS52_13635	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GQS52_13640	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GQS52_13685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GQS52_13770	COG0514	ATP-dependent DNA helicase (RecQ)
GQS52_13800	COG1136	(ABC) transporter
GQS52_13800	COG0577	efflux transmembrane transporter activity
GQS52_13805	COG0577	efflux transmembrane transporter activity
GQS52_13815	COG2197	response regulator
GQS52_13830	COG0439	Biotin carboxylase
GQS52_13835	COG0511	ligase activity, forming carbon-carbon bonds
GQS52_13840	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GQS52_13840	COG0825	malonyl-CoA metabolic process
GQS52_13890	COG0673	inositol 2-dehydrogenase activity
GQS52_13895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GQS52_13900	COG3718	enzyme involved in inositol metabolism
GQS52_13905	COG3962	Belongs to the TPP enzyme family
GQS52_13950	COG0789	Transcriptional regulator
GQS52_13955	COG0586	Pfam SNARE associated Golgi protein
GQS52_13965	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GQS52_13970	COG2027	D-alanyl-D-alanine carboxypeptidase
GQS52_13980	COG0037	tRNA processing
GQS52_13995	COG0302	gtp cyclohydrolase
GQS52_14010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GQS52_14015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GQS52_14035	COG1174	glycine betaine transport
GQS52_14055	COG0649	NAD binding
GQS52_14065	COG4585	Histidine kinase
GQS52_14070	COG2197	response regulator
GQS52_14080	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GQS52_14085	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GQS52_14095	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GQS52_14110	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GQS52_14110	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GQS52_14125	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GQS52_14175	COG0739	heme binding
GQS52_14190	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GQS52_14210	COG0248	Ppx GppA phosphatase
GQS52_14220	COG1082	Xylose isomerase domain protein TIM barrel
GQS52_14225	COG0129	dihydroxy-acid dehydratase activity
GQS52_14240	COG2326	polyphosphate kinase activity
GQS52_14250	COG0659	secondary active sulfate transmembrane transporter activity
GQS52_14265	COG0506	proline dehydrogenase activity
GQS52_14270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GQS52_14325	COG0123	including yeast histone deacetylase and acetoin utilization protein
GQS52_14375	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GQS52_14380	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GQS52_14385	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GQS52_14390	COG0181	hydroxymethylbilane synthase activity
GQS52_14395	COG1587	Uroporphyrinogen-III synthase
GQS52_14395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GQS52_14400	COG0113	porphobilinogen synthase activity
GQS52_14415	COG1690	Belongs to the RtcB family
GQS52_14430	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GQS52_14430	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GQS52_14445	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GQS52_14450	COG0406	alpha-ribazole phosphatase activity
GQS52_14455	COG0693	protein deglycase activity
GQS52_14460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GQS52_14465	COG0785	Cytochrome C biogenesis protein
GQS52_14470	COG1333	cytochrome c biogenesis protein
GQS52_14475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GQS52_14490	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GQS52_14495	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GQS52_14505	COG0163	prenyltransferase activity
GQS52_14510	COG1522	sequence-specific DNA binding
GQS52_14515	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GQS52_14540	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GQS52_14545	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GQS52_14550	COG1228	amidohydrolase
GQS52_14555	COG2226	methyltransferase
GQS52_14570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GQS52_14595	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GQS52_14605	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GQS52_14610	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GQS52_14615	COG0649	NAD binding
GQS52_14625	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GQS52_14630	COG1034	ATP synthesis coupled electron transport
GQS52_14635	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GQS52_14640	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GQS52_14650	COG0713	ATP synthesis coupled electron transport
GQS52_14655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GQS52_14665	COG1007	ATP synthesis coupled electron transport
GQS52_14670	COG1733	regulation of RNA biosynthetic process
GQS52_14680	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GQS52_14700	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
GQS52_14705	COG1396	sequence-specific DNA binding
GQS52_14710	COG0488	(ABC) transporter
GQS52_14715	COG4257	antibiotic catabolic process
GQS52_14725	COG1013	pyruvate-flavodoxin oxidoreductase activity
GQS52_14730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GQS52_14730	COG0674	pyruvate-flavodoxin oxidoreductase activity
GQS52_14740	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GQS52_14745	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GQS52_14750	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GQS52_14755	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GQS52_14760	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GQS52_14770	COG0713	ATP synthesis coupled electron transport
GQS52_14775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GQS52_14785	COG1007	ATP synthesis coupled electron transport
GQS52_14790	COG0501	Belongs to the peptidase M48B family
GQS52_14795	COG3304	Inner membrane component domain
GQS52_14830	COG1666	GTP binding
GQS52_14865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GQS52_14870	COG0702	epimerase
GQS52_14875	COG0402	S-adenosylhomocysteine deaminase activity
GQS52_14890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GQS52_14895	COG2030	dehydratase
GQS52_14905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GQS52_14910	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GQS52_14915	COG0436	Aminotransferase
GQS52_14930	COG0250	Participates in transcription elongation, termination and antitermination
GQS52_14935	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GQS52_14940	COG0081	regulation of translation
GQS52_14945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GQS52_14950	COG0222	ribosome binding
GQS52_14955	COG0085	RNA polymerase activity
GQS52_14960	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GQS52_14970	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GQS52_14975	COG0049	tRNA binding
GQS52_14980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GQS52_14985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GQS52_14995	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GQS52_15010	COG0051	transcription antitermination factor activity, RNA binding
GQS52_15015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GQS52_15020	COG0088	Forms part of the polypeptide exit tunnel
GQS52_15025	COG0089	rRNA binding
GQS52_15030	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GQS52_15035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GQS52_15040	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GQS52_15045	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GQS52_15050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GQS52_15055	COG0255	Belongs to the universal ribosomal protein uL29 family
GQS52_15060	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GQS52_15065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GQS52_15070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GQS52_15075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GQS52_15080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GQS52_15085	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GQS52_15090	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GQS52_15095	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GQS52_15100	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GQS52_15110	COG0200	Binds to the 23S rRNA
GQS52_15115	COG0201	protein transport
GQS52_15120	COG0563	adenylate kinase activity
GQS52_15130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GQS52_15135	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GQS52_15140	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GQS52_15145	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GQS52_15155	COG0203	ribosomal protein L17
GQS52_15160	COG0101	tRNA pseudouridine synthase activity
GQS52_15170	COG1309	transcriptional regulator
GQS52_15180	COG0488	(ABC) transporter
GQS52_15185	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GQS52_15190	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GQS52_15195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GQS52_15215	COG1072	(Pantothenic acid kinase))
GQS52_15225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GQS52_15230	COG0736	holo-[acyl-carrier-protein] synthase activity
GQS52_15240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GQS52_15250	COG0802	atpase or kinase
GQS52_15275	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GQS52_15290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GQS52_15310	COG2197	response regulator
GQS52_15315	COG1595	DNA-templated transcription, initiation
GQS52_15325	COG0516	GMP reductase activity
GQS52_15335	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GQS52_15355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GQS52_15360	COG1012	belongs to the aldehyde dehydrogenase family
GQS52_15375	COG0494	nUDIX hydrolase
GQS52_15400	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GQS52_15405	COG1120	ATPase activity
GQS52_15410	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GQS52_15415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GQS52_15430	COG1278	Cold shock
GQS52_15435	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GQS52_15440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GQS52_15475	COG2252	PERMEase
GQS52_15490	COG2814	Major facilitator Superfamily
GQS52_15505	COG2855	membrane
GQS52_15510	COG0583	DNA-binding transcription factor activity
GQS52_15515	COG0667	Aldo Keto reductase
GQS52_15530	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GQS52_15540	COG0259	pyridoxamine-phosphate oxidase activity
GQS52_15550	COG4821	SIS domain
GQS52_15560	COG0596	Alpha beta hydrolase
GQS52_15560	COG2945	thiolester hydrolase activity
GQS52_15605	COG1366	Belongs to the anti-sigma-factor antagonist family
GQS52_15615	COG2301	Belongs to the HpcH HpaI aldolase family
GQS52_15620	COG2301	Belongs to the HpcH HpaI aldolase family
GQS52_15625	COG1309	transcriptional regulator
GQS52_15635	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GQS52_15635	COG0515	serine threonine protein kinase
GQS52_15645	COG3629	intracellular signal transduction
GQS52_15645	COG3903	Transcriptional regulator
GQS52_15660	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GQS52_15725	COG0582	viral genome integration into host DNA
GQS52_15775	COG2188	Transcriptional regulator
GQS52_15825	COG1280	lysine exporter protein (LysE YggA)
GQS52_15855	COG0446	pyridine nucleotide-disulphide oxidoreductase
GQS52_15860	COG2409	Drug exporters of the RND superfamily
GQS52_15870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GQS52_15875	COG0450	alkyl hydroperoxide reductase
GQS52_15880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GQS52_15910	COG1846	Transcriptional regulator
GQS52_15940	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GQS52_15955	COG3263	regulation of cellular component size
GQS52_15965	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GQS52_15970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GQS52_15980	COG0315	cyclic pyranopterin monophosphate synthase activity
GQS52_15985	COG0315	cyclic pyranopterin monophosphate synthase activity
GQS52_15985	COG0521	Mo-molybdopterin cofactor biosynthetic process
GQS52_15990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GQS52_16005	COG0667	Aldo Keto reductase
GQS52_16015	COG2175	clavaminate synthase activity
GQS52_16025	COG0137	argininosuccinate synthase activity
GQS52_16030	COG2175	clavaminate synthase activity
GQS52_16040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GQS52_16050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GQS52_16060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GQS52_16090	COG2175	clavaminate synthase activity
GQS52_16140	COG0531	amino acid
GQS52_16160	COG1404	Belongs to the peptidase S8 family
GQS52_16165	COG1672	PFAM Archaeal ATPase
GQS52_16165	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GQS52_16185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GQS52_16205	COG1396	sequence-specific DNA binding
GQS52_16225	COG0789	Transcriptional regulator
GQS52_16230	COG2072	flavoprotein involved in K transport
GQS52_16240	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_16250	COG0793	Belongs to the peptidase S41A family
GQS52_16250	COG4946	Tricorn protease homolog
GQS52_16265	COG1122	ATPase activity
GQS52_16305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GQS52_16310	COG0084	hydrolase, TatD family'
GQS52_16315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GQS52_16320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GQS52_16340	COG0488	(ABC) transporter
GQS52_16360	COG2197	response regulator
GQS52_16370	COG4106	trans-aconitate 2-methyltransferase activity
GQS52_16390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GQS52_16395	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GQS52_16400	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GQS52_16405	COG0193	aminoacyl-tRNA hydrolase activity
GQS52_16420	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GQS52_16515	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GQS52_16565	COG1515	deoxyribonuclease V activity
GQS52_16570	COG2124	cytochrome p450
GQS52_16580	COG1652	LysM domain
GQS52_16590	COG0148	phosphopyruvate hydratase activity
GQS52_16630	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GQS52_16635	COG1136	(ABC) transporter
GQS52_16635	COG0577	efflux transmembrane transporter activity
GQS52_16640	COG0577	efflux transmembrane transporter activity
GQS52_16640	COG1136	(ABC) transporter
GQS52_16665	COG0183	Belongs to the thiolase family
GQS52_16670	COG2755	lipolytic protein G-D-S-L family
GQS52_16680	COG0318	PFAM AMP-dependent synthetase and ligase
GQS52_16700	COG1113	amino acid transport
GQS52_16705	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GQS52_16720	COG1228	amidohydrolase
GQS52_16725	COG1191	sigma factor activity
GQS52_16740	COG3104	oligopeptide transport
GQS52_16745	COG0745	RESPONSE REGULATOR receiver
GQS52_16750	COG2205	protein histidine kinase activity
GQS52_16775	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GQS52_16785	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GQS52_16790	COG1595	DNA-templated transcription, initiation
GQS52_16800	COG1316	TRANSCRIPTIONal
GQS52_16850	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GQS52_16875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GQS52_16895	COG0312	modulator of DNA gyrase
GQS52_16920	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GQS52_16935	COG1316	TRANSCRIPTIONal
GQS52_16945	COG1316	TRANSCRIPTIONal
GQS52_16950	COG1316	TRANSCRIPTIONal
GQS52_16980	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GQS52_16980	COG0778	Nitroreductase
GQS52_16985	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GQS52_17020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GQS52_17025	COG2835	tetraacyldisaccharide 4'-kinase activity
GQS52_17035	COG1482	cell wall glycoprotein biosynthetic process
GQS52_17045	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GQS52_17105	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GQS52_17110	COG0745	RESPONSE REGULATOR receiver
GQS52_17115	COG5002	protein histidine kinase activity
GQS52_17120	COG0823	Involved in the tonB-independent uptake of proteins
GQS52_17130	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GQS52_17135	COG2197	response regulator
GQS52_17140	COG3214	Protein conserved in bacteria
GQS52_17150	COG0653	protein targeting
GQS52_17170	COG1012	belongs to the aldehyde dehydrogenase family
GQS52_17175	COG2902	Dehydrogenase
GQS52_17185	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GQS52_17190	COG0671	phosphoesterase, PA-phosphatase related
GQS52_17195	COG0277	FAD linked oxidase domain protein
GQS52_17220	COG0395	ABC-type sugar transport system, permease component
GQS52_17225	COG1175	transmembrane transport
GQS52_17235	COG1716	ATPase activity
GQS52_17240	COG0515	serine threonine protein kinase
GQS52_17245	COG0515	serine threonine protein kinase
GQS52_17250	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GQS52_17265	COG2884	Cell division ATP-binding protein ftsE
GQS52_17275	COG0793	Belongs to the peptidase S41A family
GQS52_17280	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GQS52_17290	COG2223	nitrite transmembrane transporter activity
GQS52_17305	COG3973	AAA domain
GQS52_17315	COG0776	regulation of translation
GQS52_17320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GQS52_17325	COG1678	Uncharacterized ACR, COG1678
GQS52_17345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GQS52_17360	COG2409	Drug exporters of the RND superfamily
GQS52_17405	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GQS52_17410	COG0277	FAD linked oxidase domain protein
GQS52_17445	COG1335	isochorismatase
GQS52_17455	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GQS52_17465	COG1115	amino acid carrier protein
GQS52_17485	COG1234	tRNA 3'-trailer cleavage
GQS52_17490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GQS52_17495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GQS52_17500	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GQS52_17530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GQS52_17535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GQS52_17550	COG2733	membrane
GQS52_17560	COG0706	membrane insertase activity
GQS52_17565	COG4702	Belongs to the UPF0303 family
GQS52_17570	COG0673	inositol 2-dehydrogenase activity
GQS52_17575	COG1940	carbohydrate kinase activity
GQS52_17595	COG0318	PFAM AMP-dependent synthetase and ligase
GQS52_17600	COG2508	Transcriptional regulator
GQS52_17600	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GQS52_17605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GQS52_17625	COG1126	abc transporter atp-binding protein
GQS52_17630	COG0765	amino acid transport
GQS52_17640	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GQS52_17645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GQS52_17660	COG2018	Roadblock/LC7 domain
GQS52_17670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GQS52_17725	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GQS52_17740	COG1175	transmembrane transport
GQS52_17790	COG1960	acyl-CoA dehydrogenase activity
GQS52_17805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GQS52_17810	COG1309	transcriptional regulator
GQS52_17835	COG0183	Belongs to the thiolase family
GQS52_17840	COG1946	Acyl-CoA thioesterase
GQS52_17845	COG2208	phosphoserine phosphatase activity
GQS52_17845	COG2770	Histidine kinase
GQS52_17875	COG1132	(ABC) transporter
GQS52_17900	COG1869	D-ribose catabolic process
GQS52_17905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GQS52_17915	COG1129	ABC transporter
GQS52_17925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GQS52_17955	COG0019	diaminopimelate decarboxylase activity
GQS52_17960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GQS52_17960	COG4651	solute:proton antiporter activity
GQS52_17970	COG0501	Belongs to the peptidase M48B family
GQS52_18000	COG1215	transferase activity, transferring glycosyl groups
GQS52_18040	COG1051	belongs to the nudix hydrolase family
GQS52_18095	COG1674	ftsk spoiiie
GQS52_18195	COG2346	COG2346, Truncated hemoglobins
GQS52_18220	COG1486	melibiose metabolic process
GQS52_18225	COG0668	transmembrane transport
GQS52_18240	COG1136	(ABC) transporter
GQS52_18250	COG3291	Pkd domain containing protein
GQS52_18250	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GQS52_18340	COG0583	DNA-binding transcription factor activity
GQS52_18355	COG4865	methylaspartate mutase activity
GQS52_18365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GQS52_18415	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GQS52_18420	COG1113	amino acid transport
GQS52_18430	COG1113	amino acid transport
GQS52_18435	COG0698	ribose 5-phosphate isomerase
GQS52_18445	COG4552	Acetyltransferase involved in intracellular survival and related
GQS52_18455	COG3594	Acyltransferase
GQS52_18480	COG0544	peptidyl-prolyl cis-trans isomerase activity
GQS52_18485	COG0740	serine-type endopeptidase activity
GQS52_18490	COG0740	serine-type endopeptidase activity
GQS52_18495	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GQS52_18505	COG0525	valine-tRNA ligase activity
GQS52_18510	COG0285	dihydrofolate synthase activity
GQS52_18520	COG0105	UTP biosynthetic process
GQS52_18525	COG1077	Cell shape determining protein MreB Mrl
GQS52_18540	COG0768	penicillin binding
GQS52_18545	COG0772	Belongs to the SEDS family
GQS52_18565	COG1530	ribonuclease E activity
GQS52_18570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GQS52_18580	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GQS52_18590	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GQS52_18600	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GQS52_18615	COG0501	Belongs to the peptidase M48B family
GQS52_18620	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GQS52_18655	COG0495	leucyl-tRNA aminoacylation
GQS52_18665	COG1307	EDD domain protein, DegV family
GQS52_18690	COG0268	Binds directly to 16S ribosomal RNA
GQS52_18695	COG0481	GTPase activity
GQS52_18700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GQS52_18705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GQS52_18710	COG1120	ATPase activity
GQS52_18740	COG1420	regulation of RNA biosynthetic process
GQS52_18745	COG0484	heat shock protein binding
GQS52_18750	COG2070	2-Nitropropane dioxygenase
GQS52_18760	COG1012	belongs to the aldehyde dehydrogenase family
GQS52_18770	COG0517	IMP dehydrogenase activity
GQS52_18770	COG4175	Glycine betaine
GQS52_18775	COG4176	ABC-type proline glycine betaine transport system permease component
GQS52_18785	COG0793	Belongs to the peptidase S41A family
GQS52_18785	COG4946	Tricorn protease homolog
GQS52_18840	COG1160	GTP binding
GQS52_18865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GQS52_18880	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
GQS52_18950	COG2197	response regulator
GQS52_18955	COG4585	Histidine kinase
GQS52_18975	COG0662	Cupin 2, conserved barrel domain protein
GQS52_18995	COG0590	tRNA wobble adenosine to inosine editing
GQS52_19000	COG2313	pseudouridylate synthase activity
GQS52_19005	COG0546	phosphoglycolate phosphatase activity
GQS52_19030	COG0537	adenosine 5'-monophosphoramidase activity
GQS52_19035	COG1234	tRNA 3'-trailer cleavage
GQS52_19040	COG1486	melibiose metabolic process
GQS52_19055	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GQS52_19070	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GQS52_19085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GQS52_19095	COG1381	Involved in DNA repair and RecF pathway recombination
GQS52_19100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GQS52_19125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GQS52_19125	COG1321	iron dependent repressor
GQS52_19130	COG1121	(ABC) transporter
GQS52_19140	COG0423	glycine-tRNA ligase activity
GQS52_19160	COG1175	transmembrane transport
GQS52_19165	COG0395	ABC-type sugar transport system, permease component
GQS52_19170	COG0574	Belongs to the PEP-utilizing enzyme family
GQS52_19170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GQS52_19180	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GQS52_19190	COG0277	FAD linked oxidase domain protein
GQS52_19200	COG4552	Acetyltransferase involved in intracellular survival and related
GQS52_19210	COG1309	transcriptional regulator
GQS52_19220	COG2814	Major facilitator Superfamily
GQS52_19225	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_19240	COG0076	glutamate decarboxylase activity
GQS52_19245	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GQS52_19245	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GQS52_19260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GQS52_19260	COG2146	nitrite reductase [NAD(P)H] activity
GQS52_19265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GQS52_19275	COG0243	molybdopterin cofactor binding
GQS52_19280	COG2949	membrane
GQS52_19295	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GQS52_19305	COG0358	DNA primase activity
GQS52_19310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GQS52_19315	COG1070	Carbohydrate kinase
GQS52_19350	COG1012	belongs to the aldehyde dehydrogenase family
GQS52_19385	COG2130	NADP-dependent
GQS52_19405	COG2197	response regulator
GQS52_19425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GQS52_19430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GQS52_19435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GQS52_19460	COG0789	Transcriptional regulator
GQS52_19465	COG0667	Aldo Keto reductase
GQS52_19490	COG2197	response regulator
GQS52_19495	COG4585	Histidine kinase
GQS52_19510	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GQS52_19555	COG1358	cellular component organization or biogenesis
GQS52_19590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GQS52_19595	COG0444	Belongs to the ABC transporter superfamily
GQS52_19600	COG1124	(ABC) transporter
GQS52_19625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GQS52_19635	COG0745	RESPONSE REGULATOR receiver
GQS52_19670	COG0730	response to heat
GQS52_19700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GQS52_19710	COG1396	sequence-specific DNA binding
GQS52_19805	COG3845	ABC transporter
GQS52_19820	COG1657	PFAM Prenyltransferase squalene oxidase
GQS52_19830	COG1309	transcriptional regulator
GQS52_19835	COG0438	transferase activity, transferring glycosyl groups
GQS52_19840	COG2226	methyltransferase
GQS52_19875	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GQS52_19905	COG3022	response to hydroperoxide
GQS52_19925	COG1132	(ABC) transporter
GQS52_19935	COG3540	Alkaline phosphatase
GQS52_19945	COG2814	Major facilitator Superfamily
GQS52_19950	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_19960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GQS52_19980	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GQS52_19985	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GQS52_19990	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GQS52_20010	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GQS52_20020	COG0254	rRNA binding
GQS52_20025	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GQS52_20030	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GQS52_20035	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GQS52_20040	COG1834	amidinotransferase
GQS52_20055	COG0672	)-iron permease
GQS52_20060	COG2837	iron assimilation
GQS52_20090	COG1994	Peptidase M50
GQS52_20100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GQS52_20120	COG0596	Alpha beta hydrolase
GQS52_20140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GQS52_20145	COG0477	Major facilitator Superfamily
GQS52_20160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GQS52_20165	COG0587	DNA-directed DNA polymerase activity
GQS52_20170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GQS52_20170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GQS52_20175	COG2909	trisaccharide binding
GQS52_20190	COG0174	glutamine synthetase
GQS52_20200	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GQS52_20210	COG1609	Transcriptional regulator
GQS52_20215	COG0366	Alpha amylase catalytic
GQS52_20220	COG3833	ABC-type maltose transport systems, permease component
GQS52_20225	COG1175	transmembrane transport
GQS52_20245	COG0142	geranyltranstransferase activity
GQS52_20265	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GQS52_20280	COG0702	epimerase
GQS52_20335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GQS52_20340	COG0321	lipoyl(octanoyl) transferase activity
GQS52_20355	COG1309	transcriptional regulator
GQS52_20405	COG2856	Zn peptidase
GQS52_20430	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_20440	COG0508	dehydrogenase complex catalyzes the overall conversion of
GQS52_20445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GQS52_20455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GQS52_20460	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GQS52_20465	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GQS52_20480	COG0667	Aldo Keto reductase
GQS52_20485	COG2226	methyltransferase
GQS52_20505	COG4585	Histidine kinase
GQS52_20510	COG2197	response regulator
GQS52_20515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GQS52_20520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GQS52_20540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GQS52_20550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GQS52_20565	COG1376	ErfK ybiS ycfS ynhG family protein
GQS52_20575	COG1845	cytochrome c oxidase, subunit III
GQS52_20580	COG2010	Cytochrome c
GQS52_20585	COG0723	plastoquinol--plastocyanin reductase activity
GQS52_20590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GQS52_20600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GQS52_20635	COG0501	Belongs to the peptidase M48B family
GQS52_20645	COG0438	transferase activity, transferring glycosyl groups
GQS52_20665	COG0003	Pfam Anion-transporting ATPase
GQS52_20675	COG1940	carbohydrate kinase activity
GQS52_20705	COG2197	response regulator
GQS52_20720	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GQS52_20730	COG2193	ferroxidase activity
GQS52_20735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GQS52_20740	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GQS52_20745	COG2815	serine threonine protein kinase
GQS52_20745	COG0515	serine threonine protein kinase
GQS52_20750	COG2022	thiamine diphosphate biosynthetic process
GQS52_20760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GQS52_20760	COG2022	thiamine diphosphate biosynthetic process
GQS52_20780	COG0352	thiamine-phosphate diphosphorylase activity
GQS52_20795	COG1233	COG1233 Phytoene dehydrogenase and related
GQS52_20800	COG1309	transcriptional regulator
GQS52_20810	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GQS52_20845	COG0714	Associated with various cellular activities
GQS52_20855	COG2001	Belongs to the MraZ family
GQS52_20860	COG0275	rRNA processing
GQS52_20875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GQS52_20885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GQS52_20890	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GQS52_20900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GQS52_20905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GQS52_20910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GQS52_20925	COG1799	cell septum assembly
GQS52_20935	COG3599	regulation of cell shape
GQS52_20945	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GQS52_20955	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GQS52_20970	COG0025	NhaP-type Na H and K H
GQS52_21040	COG0587	DNA-directed DNA polymerase activity
GQS52_21065	COG1653	transport
GQS52_21070	COG1175	transmembrane transport
GQS52_21075	COG0395	ABC-type sugar transport system, permease component
GQS52_21090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GQS52_21115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GQS52_21120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GQS52_21125	COG0131	Imidazoleglycerol-phosphate dehydratase
GQS52_21130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GQS52_21135	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GQS52_21140	COG0251	oxidation-reduction process
GQS52_21145	COG0107	imidazoleglycerol-phosphate synthase activity
GQS52_21185	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GQS52_21190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GQS52_21210	COG0134	indole-3-glycerol-phosphate synthase activity
GQS52_21220	COG0133	tryptophan synthase activity
GQS52_21225	COG0159	tryptophan synthase activity
GQS52_21235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GQS52_21245	COG0070	glutamate synthase
GQS52_21245	COG0069	glutamate synthase activity
GQS52_21245	COG0067	glutamate synthase
GQS52_21260	COG1473	amidohydrolase
GQS52_21300	COG0411	ABC transporter
GQS52_21320	COG2050	protein possibly involved in aromatic compounds catabolism
GQS52_21345	COG1643	Atp-dependent helicase
GQS52_21370	COG0237	dephospho-CoA kinase activity
GQS52_21405	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GQS52_21410	COG0556	nucleotide-excision repair
GQS52_21435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GQS52_21445	COG0322	excinuclease ABC activity
GQS52_21450	COG1660	Displays ATPase and GTPase activities
GQS52_21460	COG1481	regulation of sporulation
GQS52_21465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GQS52_21470	COG0126	phosphoglycerate kinase activity
GQS52_21475	COG0149	triose-phosphate isomerase activity
GQS52_21480	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GQS52_21490	COG0363	glucosamine-6-phosphate deaminase activity
GQS52_21505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GQS52_21515	COG0109	protoheme IX farnesyltransferase activity
GQS52_21525	COG1612	heme a metabolic process
GQS52_21535	COG1131	(ABC) transporter
GQS52_21550	COG0719	Fe-S assembly protein
GQS52_21560	COG0396	ATPase activity
GQS52_21565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GQS52_21570	COG0822	iron-sulfur transferase activity
GQS52_21580	COG2171	N-acyltransferase activity
GQS52_21585	COG1295	ribonuclease BN
GQS52_21630	COG0564	pseudouridine synthase activity
GQS52_21650	COG1917	Cupin 2, conserved barrel domain protein
GQS52_21655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GQS52_21670	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GQS52_21695	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GQS52_21725	COG1797	cobyrinic acid a,c-diamide synthase activity
GQS52_21745	COG1492	cobalamin metabolic process
GQS52_21750	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GQS52_21755	COG2826	transposase and inactivated derivatives, IS30 family
GQS52_21775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GQS52_21780	COG0235	Class ii aldolase
GQS52_21795	COG1793	dna ligase
GQS52_21795	COG3285	dna ligase
GQS52_21800	COG0488	(ABC) transporter
GQS52_21810	COG1024	Enoyl-CoA hydratase
GQS52_21820	COG3387	PFAM Glycoside hydrolase 15-related
GQS52_21835	COG1199	ATP-dependent helicase activity
GQS52_21835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GQS52_21850	COG1404	Belongs to the peptidase S8 family
GQS52_21860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GQS52_21865	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GQS52_21885	COG2261	transglycosylase associated protein
GQS52_21890	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
GQS52_21905	COG2208	phosphoserine phosphatase activity
GQS52_21905	COG2770	Histidine kinase
GQS52_21910	COG0640	Transcriptional regulator
GQS52_21975	COG4942	peptidase
GQS52_21995	COG1136	(ABC) transporter
GQS52_22005	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_22010	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GQS52_22015	COG2186	Transcriptional regulator
GQS52_22035	COG0560	Phosphoserine phosphatase
GQS52_22035	COG3830	Belongs to the UPF0237 family
GQS52_22040	COG1716	ATPase activity
GQS52_22040	COG0842	Transport permease protein
GQS52_22040	COG1131	(ABC) transporter
GQS52_22050	COG4585	Histidine kinase
GQS52_22055	COG2197	response regulator
GQS52_22065	COG1119	ATPase activity
GQS52_22090	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GQS52_22100	COG1881	PFAM PEBP family protein
GQS52_22110	COG2094	Belongs to the DNA glycosylase MPG family
GQS52_22115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GQS52_22150	COG0647	UMP catabolic process
GQS52_22180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GQS52_22185	COG0497	DNA recombination
GQS52_22200	COG3387	PFAM Glycoside hydrolase 15-related
GQS52_22205	COG0504	CTP synthase activity
GQS52_22210	COG0494	nUDIX hydrolase
GQS52_22220	COG0686	Belongs to the AlaDH PNT family
GQS52_22235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GQS52_22240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GQS52_22245	COG1187	pseudouridine synthase activity
GQS52_22265	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GQS52_22275	COG1160	GTP binding
GQS52_22290	COG0438	transferase activity, transferring glycosyl groups
GQS52_22360	COG0671	phosphoesterase, PA-phosphatase related
GQS52_22365	COG0477	Major facilitator Superfamily
GQS52_22370	COG1960	acyl-CoA dehydrogenase activity
GQS52_22375	COG1799	cell septum assembly
GQS52_22390	COG0330	HflC and HflK could
GQS52_22420	COG1725	Transcriptional regulator
GQS52_22440	COG2755	lipolytic protein G-D-S-L family
GQS52_22475	COG2267	carboxylic ester hydrolase activity
GQS52_22500	COG0318	PFAM AMP-dependent synthetase and ligase
GQS52_22515	COG1309	transcriptional regulator
GQS52_22530	COG1960	acyl-CoA dehydrogenase activity
GQS52_22550	COG3265	gluconokinase activity
GQS52_22565	COG2149	membrane
GQS52_22570	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GQS52_22580	COG1309	transcriptional regulator
GQS52_22585	COG1960	acyl-CoA dehydrogenase activity
GQS52_22590	COG1960	acyl-CoA dehydrogenase activity
GQS52_22605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GQS52_22630	COG0667	Aldo Keto reductase
GQS52_22635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GQS52_22645	COG0598	Magnesium transport protein CorA
GQS52_22665	COG4585	Histidine kinase
GQS52_22680	COG0215	cysteine-tRNA ligase activity
GQS52_22695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GQS52_22710	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GQS52_22730	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GQS52_22750	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GQS52_22755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GQS52_22760	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GQS52_22765	COG1414	Transcriptional regulator
GQS52_22770	COG1410	methionine synthase
GQS52_22770	COG0646	methionine synthase
GQS52_22785	COG4166	transmembrane transport
GQS52_22790	COG2197	response regulator
GQS52_22800	COG1994	Peptidase M50
GQS52_22800	COG0517	IMP dehydrogenase activity
GQS52_22820	COG1222	aaa ATPase
GQS52_22825	COG4122	O-methyltransferase activity
GQS52_22835	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GQS52_22845	COG1609	Transcriptional regulator
GQS52_22855	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GQS52_22870	COG2378	regulation of single-species biofilm formation
GQS52_22890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GQS52_22895	COG0805	protein transport
GQS52_22910	COG2391	methyltransferase activity
GQS52_22915	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GQS52_22920	COG4412	M6 family metalloprotease domain protein
GQS52_22920	COG1404	Belongs to the peptidase S8 family
GQS52_22935	COG3284	Transcriptional regulator
GQS52_22975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GQS52_22980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GQS52_22985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GQS52_22990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GQS52_22995	COG5002	protein histidine kinase activity
GQS52_23000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GQS52_23005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GQS52_23005	COG0072	phenylalanine-tRNA ligase activity
GQS52_23020	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GQS52_23060	COG1649	PFAM Uncharacterised BCR, COG1649
GQS52_23075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GQS52_23080	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GQS52_23085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GQS52_23090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GQS52_23095	COG1438	arginine binding
GQS52_23100	COG0165	Argininosuccinate lyase
GQS52_23105	COG0318	PFAM AMP-dependent synthetase and ligase
GQS52_23105	COG0204	Acyl-transferase
GQS52_23110	COG0584	glycerophosphoryl diester phosphodiesterase
GQS52_23135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GQS52_23140	COG2011	ABC-type metal ion transport system permease component
GQS52_23145	COG1464	Belongs to the NlpA lipoprotein family
GQS52_23165	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GQS52_23170	COG1648	precorrin-2 dehydrogenase activity
GQS52_23170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GQS52_23180	COG1959	2 iron, 2 sulfur cluster binding
GQS52_23250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GQS52_23255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GQS52_23260	COG0454	-acetyltransferase
GQS52_23260	COG0456	acetyltransferase
GQS52_23305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GQS52_23325	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GQS52_23330	COG1560	Kdo2-lipid A biosynthetic process
GQS52_23335	COG0438	transferase activity, transferring glycosyl groups
GQS52_23345	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GQS52_23350	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GQS52_23355	COG0217	transcriptional regulatory protein
GQS52_23360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GQS52_23365	COG0632	four-way junction helicase activity
GQS52_23370	COG2255	four-way junction helicase activity
GQS52_23380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GQS52_23385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GQS52_23390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GQS52_23395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GQS52_23400	COG1196	nuclear chromosome segregation
GQS52_23405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GQS52_23415	COG0124	histidyl-tRNA synthetase
GQS52_23420	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GQS52_23440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GQS52_23455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GQS52_23460	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GQS52_23465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GQS52_23470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GQS52_23475	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GQS52_23480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GQS52_23485	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GQS52_23490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GQS52_23500	COG0006	proline dipeptidase activity
GQS52_23505	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GQS52_23510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GQS52_23515	COG0076	glutamate decarboxylase activity
GQS52_23540	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GQS52_23545	COG0540	Belongs to the ATCase OTCase family
GQS52_23550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GQS52_23560	COG0505	Belongs to the CarA family
GQS52_23565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GQS52_23570	COG0167	dihydroorotate dehydrogenase activity
GQS52_23575	COG0284	orotidine-5'-phosphate decarboxylase activity
GQS52_23600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GQS52_23615	COG0242	peptide deformylase activity
GQS52_23620	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GQS52_23630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GQS52_23635	COG2390	Transcriptional regulator
GQS52_23655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GQS52_23660	COG1937	Protein conserved in bacteria
GQS52_23665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GQS52_23690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GQS52_23705	COG2233	PERMEase
GQS52_23730	COG3201	nicotinamide mononucleotide transporter
GQS52_23735	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GQS52_23735	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GQS52_23740	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GQS52_23745	COG0140	phosphoribosyl-ATP diphosphatase activity
GQS52_23750	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GQS52_23795	COG0166	Belongs to the GPI family
GQS52_23825	COG2030	dehydratase
GQS52_23870	COG2226	methyltransferase
GQS52_23875	COG2217	Heavy metal translocating P-type atpase
GQS52_23945	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GQS52_23950	COG0514	ATP-dependent DNA helicase (RecQ)
GQS52_23955	COG0517	IMP dehydrogenase activity
GQS52_23975	COG0784	Response regulator, receiver
GQS52_23980	COG4251	negative regulation of phosphorylation
GQS52_23985	COG0784	Response regulator, receiver
GQS52_23985	COG2205	protein histidine kinase activity
GQS52_23985	COG5002	protein histidine kinase activity
GQS52_24180	COG2318	DinB family
GQS52_24195	COG0583	DNA-binding transcription factor activity
GQS52_24210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GQS52_24220	COG2815	serine threonine protein kinase
GQS52_24220	COG0515	serine threonine protein kinase
GQS52_24245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GQS52_24255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GQS52_24255	COG0574	Belongs to the PEP-utilizing enzyme family
GQS52_24265	COG0517	IMP dehydrogenase activity
GQS52_24265	COG0516	GMP reductase activity
GQS52_24275	COG1063	alcohol dehydrogenase
GQS52_24280	COG0516	GMP reductase activity
GQS52_24280	COG0517	IMP dehydrogenase activity
GQS52_24305	COG1250	3-hydroxyacyl-CoA dehydrogenase
GQS52_24310	COG2261	transglycosylase associated protein
GQS52_24325	COG1595	DNA-templated transcription, initiation
GQS52_24370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GQS52_24385	COG2318	DinB family
GQS52_24410	COG2197	response regulator
GQS52_24440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GQS52_24495	COG1280	lysine exporter protein (LysE YggA)
GQS52_24510	COG3396	Phenylacetate-CoA oxygenase
GQS52_24515	COG3460	Phenylacetate-CoA oxygenase
GQS52_24520	COG3396	Phenylacetate-CoA oxygenase
GQS52_24525	COG2151	metal-sulfur cluster biosynthetic enzyme
GQS52_24530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GQS52_24535	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GQS52_24540	COG0310	cobalt ion transport
GQS52_24545	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
GQS52_24555	COG1122	ATPase activity
GQS52_24600	COG1278	Cold shock
GQS52_24640	COG1335	isochorismatase
GQS52_24670	COG1216	Glycosyl transferase, family 2
GQS52_24675	COG3030	protein affecting phage T7 exclusion by the F plasmid
GQS52_24685	COG2270	Major facilitator Superfamily
GQS52_24695	COG0584	glycerophosphoryl diester phosphodiesterase
GQS52_24705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GQS52_24855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GQS52_24890	COG1914	H( )-stimulated, divalent metal cation uptake system
GQS52_24905	COG1063	alcohol dehydrogenase
GQS52_24930	COG1252	NADH dehydrogenase
GQS52_24955	COG1595	DNA-templated transcription, initiation
GQS52_24990	COG1357	PFAM Pentapeptide repeats (8 copies)
GQS52_24995	COG0596	Alpha beta hydrolase
GQS52_25025	COG0506	proline dehydrogenase activity
GQS52_25030	COG1012	belongs to the aldehyde dehydrogenase family
GQS52_25035	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GQS52_25040	COG1191	sigma factor activity
GQS52_25070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GQS52_25120	COG2890	protein-(glutamine-N5) methyltransferase activity
GQS52_25135	COG1846	Transcriptional regulator
GQS52_25140	COG1764	response to oxidative stress
GQS52_25145	COG0723	plastoquinol--plastocyanin reductase activity
GQS52_25180	COG0753	catalase activity
GQS52_25185	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_25215	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
GQS52_25230	COG0531	amino acid
GQS52_25255	COG0574	Belongs to the PEP-utilizing enzyme family
GQS52_25255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GQS52_25300	COG0028	Belongs to the TPP enzyme family
GQS52_25320	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GQS52_25345	COG0375	protein maturation
GQS52_25350	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GQS52_25355	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GQS52_25365	COG0409	Hydrogenase expression formation protein
GQS52_25370	COG0309	Hydrogenase expression formation protein (HypE)
GQS52_25380	COG2267	carboxylic ester hydrolase activity
GQS52_25440	COG1140	nitrate reductase beta subunit
GQS52_25470	COG2124	cytochrome p450
GQS52_25475	COG3903	Transcriptional regulator
GQS52_25475	COG3629	intracellular signal transduction
GQS52_25490	COG3383	formate dehydrogenase (NAD+) activity
GQS52_25500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GQS52_25505	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GQS52_25510	COG0508	dehydrogenase complex catalyzes the overall conversion of
GQS52_25510	COG0022	dehydrogenase e1 component
GQS52_25515	COG0508	dehydrogenase complex catalyzes the overall conversion of
GQS52_25545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GQS52_25560	COG3844	kynureninase activity
GQS52_25570	COG1522	sequence-specific DNA binding
GQS52_25580	COG3795	YCII-related domain
GQS52_25585	COG1309	transcriptional regulator
GQS52_25620	COG2124	cytochrome p450
GQS52_25680	COG0523	cobalamin synthesis protein
GQS52_25695	COG0789	Transcriptional regulator
GQS52_25720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GQS52_25770	COG0778	Nitroreductase
GQS52_25775	COG0697	spore germination
GQS52_25785	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GQS52_25790	COG0569	domain protein
GQS52_25805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GQS52_25825	COG3971	2-oxopent-4-enoate hydratase activity
GQS52_25845	COG0346	lactoylglutathione lyase activity
GQS52_25870	COG1960	acyl-CoA dehydrogenase activity
GQS52_25890	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_25895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GQS52_25905	COG0183	Belongs to the thiolase family
GQS52_25915	COG0183	Belongs to the thiolase family
GQS52_25920	COG2030	dehydratase
GQS52_25955	COG0318	PFAM AMP-dependent synthetase and ligase
GQS52_25960	COG1902	pentaerythritol trinitrate reductase activity
GQS52_25960	COG0446	pyridine nucleotide-disulphide oxidoreductase
GQS52_25970	COG1960	acyl-CoA dehydrogenase activity
GQS52_25975	COG2030	dehydratase
GQS52_25980	COG1960	acyl-CoA dehydrogenase activity
GQS52_25990	COG0183	Belongs to the thiolase family
GQS52_26000	COG2318	DinB family
GQS52_26030	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
GQS52_26040	COG0831	urea catabolic process
GQS52_26040	COG0832	Belongs to the urease beta subunit family
GQS52_26045	COG0804	urea catabolic process
GQS52_26055	COG0477	Major facilitator Superfamily
GQS52_26155	COG1619	proteins homologs of microcin C7 resistance protein MccF
GQS52_26235	COG1309	transcriptional regulator
GQS52_26255	COG2070	2-Nitropropane dioxygenase
GQS52_26260	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_26270	COG1960	acyl-CoA dehydrogenase activity
GQS52_26280	COG1024	Enoyl-CoA hydratase
GQS52_26285	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_26290	COG1960	acyl-CoA dehydrogenase activity
GQS52_26295	COG1960	acyl-CoA dehydrogenase activity
GQS52_26300	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_26305	COG0183	Belongs to the thiolase family
GQS52_26310	COG0318	PFAM AMP-dependent synthetase and ligase
GQS52_26330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GQS52_26335	COG1028	Short-chain dehydrogenase reductase Sdr
GQS52_26370	COG0596	Alpha beta hydrolase
GQS52_26375	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GQS52_26400	COG2813	Specifically methylates the guanine in position
GQS52_26420	COG0583	DNA-binding transcription factor activity
GQS52_26425	COG2315	Protein conserved in bacteria
GQS52_26450	COG0640	Transcriptional regulator
GQS52_26475	COG0596	Alpha beta hydrolase
GQS52_26480	COG0831	urea catabolic process
GQS52_26480	COG0832	Belongs to the urease beta subunit family
GQS52_26485	COG0804	urea catabolic process
GQS52_26535	COG2197	response regulator
GQS52_26575	COG0655	NAD(P)H dehydrogenase (quinone) activity
GQS52_26615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GQS52_26620	COG0137	argininosuccinate synthase activity
GQS52_26635	COG1012	belongs to the aldehyde dehydrogenase family
GQS52_26660	COG0318	PFAM AMP-dependent synthetase and ligase
GQS52_26685	COG1309	transcriptional regulator
GQS52_26690	COG1960	acyl-CoA dehydrogenase activity
GQS52_26695	COG5640	endopeptidase activity
GQS52_26705	COG0513	Belongs to the DEAD box helicase family
GQS52_26735	COG1819	glycosyl
GQS52_26745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form