locus-tag class description F3L20_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) F3L20_00015 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) F3L20_00020 ENOG4108J5G 6-phosphogluconate dehydrogenase F3L20_00025 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) F3L20_00030 ENOG4105K7N UPF0232 protein F3L20_00035 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F3L20_00040 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F3L20_00045 ENOG4108ZED Transmembrane domain of unknown function (DUF3566) F3L20_00075 ENOG4108UGD Serine Threonine protein kinase F3L20_00105 ENOG4105ZJT Cell division protein CrgA F3L20_00125 ENOG4108U4N (sortase) family F3L20_00130 ENOG4108RN7 integral membrane protein F3L20_00140 ENOG4105CJN penicillin-binding protein F3L20_00155 ENOG4105HZM Fha domain containing protein F3L20_00160 ENOG4105TV9 FHA Domain-Containing protein F3L20_00180 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) F3L20_00185 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F3L20_00190 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit F3L20_00195 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit F3L20_00200 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit F3L20_00205 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit F3L20_00230 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase F3L20_00235 ENOG4108IG5 Transcriptional regulator F3L20_00260 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) F3L20_00265 ENOG4105CVM Molybdenum cofactor synthesis domain protein F3L20_00295 ENOG4108VC7 Protein of unknown function (DUF2587) F3L20_00300 ENOG4107QPV Serine Threonine protein kinase F3L20_00315 ENOG4105CPP Dehydrogenase, E1 component F3L20_00320 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 F3L20_00365 ENOG4105DFM M18 family aminopeptidase F3L20_00370 ENOG4105CSU acyl-Coa dehydrogenase F3L20_00380 ENOG4105EUB pirin domain protein F3L20_00390 ENOG4105C9M aspartyl-trna synthetase F3L20_00405 ENOG4105KWG Pfam:DUF1696 F3L20_00410 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) F3L20_00420 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) F3L20_00435 ENOG4108KXM LysR family Transcriptional regulator F3L20_00480 ENOG4107T3P ABC, transporter F3L20_00505 ENOG4105C22 threonyL-tRNA synthetase F3L20_00515 ENOG4105CG3 alpha amylase, catalytic region F3L20_00530 ENOG4105EYF MMPL domain protein F3L20_00555 ENOG4105VEQ Cold shock protein F3L20_00565 ENOG4106NZI LysR family Transcriptional regulator F3L20_00590 ENOG4105DFW ABC transporter F3L20_00600 ENOG4108KPJ rna polymerase sigma factor F3L20_00615 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_00625 ENOG4108Q50 Histidine kinase F3L20_00685 ENOG4108KXV response regulator F3L20_00690 ENOG41065SU Two-component system sensor kinase F3L20_00705 ENOG41090G8 Toxic component of a toxin-antitoxin (TA) module. A F3L20_00725 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) F3L20_00870 ENOG4105DHP deoxycytidine triphosphate deaminase F3L20_00875 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) F3L20_00885 ENOG4108Z4X TRANSCRIPTIONal F3L20_00985 ENOG4105DF6 Fe-S oxidoreductase F3L20_00995 ENOG4105CFG Acts as a chaperone (By similarity) F3L20_01000 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ F3L20_01005 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) F3L20_01010 ENOG4105KNI merR family transcriptional Regulator F3L20_01015 ENOG4105DFW ABC transporter F3L20_01050 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F3L20_01095 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) F3L20_01110 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) F3L20_01115 ENOG4107RCW fructose-bisphosphate aldolase F3L20_01130 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) F3L20_01135 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) F3L20_01155 ENOG4105BZU Histidine kinase F3L20_01160 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_01165 ENOG4105BZU Histidine kinase F3L20_01170 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_01185 ENOG4105DIM ABC transporter F3L20_01190 ENOG4105CIG ABC transporter F3L20_01205 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis F3L20_01220 ENOG4105DRR Transcriptional regulator, GntR family F3L20_01225 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F3L20_01230 ENOG4108V4B ThiJ pfpI F3L20_01255 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) F3L20_01260 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) F3L20_01290 ENOG4105NAF rna polymerase sigma factor F3L20_01325 ENOG4107S91 Sodium hydrogen exchanger F3L20_01385 ENOG4105BZ4 penicillin-binding protein F3L20_01445 ENOG4105P8F nudix hydrolase F3L20_01460 ENOG4105D74 hydrolase F3L20_01470 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) F3L20_01475 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) F3L20_01480 ENOG4105CHH sulfate transporter F3L20_01540 ENOG4108I5C dEAD DEAH box helicase F3L20_01545 ENOG4105WN5 stage II sporulation protein F3L20_01550 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) F3L20_01555 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for F3L20_01565 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) F3L20_01575 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) F3L20_01580 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) F3L20_01600 ENOG4107T65 Integrase F3L20_01710 ENOG4105C2M dna polymerase I F3L20_01750 ENOG4105C26 Dehydrogenase F3L20_01770 ENOG4105CVK Glutamate decarboxylase F3L20_01780 ENOG4107TXC Transcriptional regulator F3L20_01785 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN F3L20_01795 ENOG4105F0N pyrophosphate phospho-hydrolase F3L20_01810 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) F3L20_01815 ENOG4108UGV hypoxanthine phosphoribosyltransferase F3L20_01825 ENOG4105EUJ GTP cyclohydrolase i F3L20_01835 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase F3L20_01870 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F3L20_01885 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_01890 ENOG4105I1F Resistance protein F3L20_01915 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) F3L20_01920 ENOG4108IYU L-aspartate oxidase F3L20_01930 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) F3L20_01970 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F3L20_01980 ENOG4105DR5 peptidase F3L20_01990 ENOG4108IG5 Transcriptional regulator F3L20_02000 ENOG4108FKE two-component system sensor kinase F3L20_02005 ENOG4108PYU two-component system response regulator F3L20_02010 ENOG41075QH Lipoprotein CseA F3L20_02015 ENOG4105NAF rna polymerase sigma factor F3L20_02020 ENOG4105CEN a g-specific adenine glycosylase F3L20_02045 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) F3L20_02060 ENOG4108JWX F3L20_02065 ENOG4107R33 ppx gppa phosphatase F3L20_02070 ENOG4105EY0 Xylose isomerase domain protein TIM barrel F3L20_02075 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) F3L20_02080 ENOG4105C01 Dihydroxy-acid dehydratase F3L20_02085 ENOG4108762 serine threonine protein kinase F3L20_02090 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein F3L20_02105 ENOG4105CJ1 ABC, transporter F3L20_02115 ENOG4105II7 pyrroline-5-carboxylate reductase F3L20_02130 ENOG4105C31 Tryptophanyl-tRNA synthetase F3L20_02155 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 F3L20_02165 ENOG4105DGU Histone deacetylase F3L20_02205 ENOG4108RXW HAD-superfamily subfamily IB hydrolase F3L20_02215 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) F3L20_02220 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) F3L20_02225 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) F3L20_02230 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) F3L20_02250 ENOG4107U9B transcriptional regulator F3L20_02260 ENOG410829K Lysine exporter protein (Lyse ygga) F3L20_02265 ENOG4108JQ1 Dehydrogenase F3L20_02275 ENOG4105D52 delta-aminolevulinic acid dehydratase F3L20_02290 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F3L20_02300 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase F3L20_02310 ENOG4105C75 arginyL-tRNA synthetase F3L20_02315 ENOG4105DK7 lysyl-tRNA synthetase F3L20_02335 ENOG4105E0Y RtcB Protein F3L20_02340 ENOG4105NAE bifunctional deaminase-reductase domain protein F3L20_02350 ENOG4105KK4 UPF0060 membrane protein F3L20_02360 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone F3L20_02375 ENOG4105ETX regulatoR F3L20_02380 ENOG41062D9 Histidine kinase F3L20_02385 ENOG4107S4Y M20 DapE family protein YgeY F3L20_02390 ENOG4105E2Y ABC, transporter F3L20_02410 ENOG4105EBM Alpha Beta Hydrolase Fold protein F3L20_02460 ENOG4105CHR reductase F3L20_02465 ENOG41082YX Transcriptional regulator, arsr family F3L20_02480 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase F3L20_02485 ENOG4108RH7 phosphoglycerate mutase F3L20_02500 ENOG4107QIV Cytochrome c biogenesis protein F3L20_02505 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) F3L20_02510 ENOG4105CRE cytochrome C F3L20_02535 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) F3L20_02540 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) F3L20_02550 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase F3L20_02560 ENOG4105DVY radical SAM domain protein F3L20_02565 ENOG4108UN4 phage SPO1 DNA polymerase-related protein F3L20_02580 ENOG4107QJT sodium dicarboxylate symporter F3L20_02600 ENOG4108R86 Transcriptional regulator F3L20_02610 ENOG4105CHR reductase F3L20_02615 ENOG4105CHU acetyl-coa acetyltransferase F3L20_02645 ENOG4105VEQ Cold shock protein F3L20_02655 ENOG4105EV6 Pfam:DUF178 F3L20_02805 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) F3L20_02815 ENOG4108NNZ chitinase F3L20_02820 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) F3L20_02845 ENOG41068JE domain protein F3L20_02855 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F3L20_02860 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain F3L20_02865 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F3L20_02875 ENOG4107QIZ NADH dehydrogenase F3L20_02880 ENOG4108IEH NADH dehydrogenase subunit g F3L20_02885 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) F3L20_02890 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F3L20_02895 ENOG41087XN oxidoreductase F3L20_02900 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F3L20_02905 ENOG4105D65 subunit l F3L20_02915 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F3L20_02920 ENOG4105C9U ATP-dependent DNA helicase RecQ F3L20_02935 ENOG410667J hydrolase F3L20_02955 ENOG4105CJ1 ABC, transporter F3L20_03005 ENOG4105ECR NmrA family F3L20_03015 ENOG4105DQU oxidoreductase, subunit beta F3L20_03020 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein F3L20_03040 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain F3L20_03045 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F3L20_03050 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain F3L20_03055 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) F3L20_03060 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F3L20_03070 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F3L20_03075 ENOG4105D65 subunit l F3L20_03080 ENOG4105C8S subunit m F3L20_03085 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F3L20_03090 ENOG4105D0M Protease HtpX homolog F3L20_03095 ENOG410901E Membrane F3L20_03105 ENOG4105Y3U Transglycosylase-associated protein F3L20_03110 ENOG4108VPT UPF0234 protein F3L20_03150 ENOG4105WDJ 50S ribosomal protein L33 F3L20_03155 ENOG410900P UPF0336 protein F3L20_03165 ENOG4107R4N Cell wall formation (By similarity) F3L20_03175 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) F3L20_03195 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) F3L20_03200 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) F3L20_03205 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) F3L20_03230 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) F3L20_03235 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) F3L20_03245 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) F3L20_03250 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) F3L20_03255 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) F3L20_03260 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) F3L20_03270 ENOG4105CPC Aldo Keto reductase F3L20_03275 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) F3L20_03280 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) F3L20_03300 ENOG4105D82 Glutamate dehydrogenase F3L20_03340 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) F3L20_03345 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) F3L20_03350 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) F3L20_03355 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) F3L20_03360 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity F3L20_03365 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) F3L20_03370 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) F3L20_03375 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) F3L20_03380 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) F3L20_03385 ENOG41082SA 50s ribosomal protein l29 F3L20_03390 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal F3L20_03395 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) F3L20_03400 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) F3L20_03405 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits F3L20_03410 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) F3L20_03420 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) F3L20_03425 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) F3L20_03430 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) F3L20_03435 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) F3L20_03440 ENOG410849U 50S ribosomal protein L30 F3L20_03445 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) F3L20_03455 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) F3L20_03465 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) F3L20_03470 ENOG41067V7 50S ribosomal protein L36 F3L20_03475 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits F3L20_03480 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) F3L20_03485 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) F3L20_03490 ENOG4108ZT0 50S ribosomal protein l17 F3L20_03495 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) F3L20_03510 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) F3L20_03515 ENOG4108UJD 30S ribosomal protein S9 F3L20_03520 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) F3L20_03530 ENOG4105CS9 pantothenic acid kinase F3L20_03540 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) F3L20_03550 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L20_03560 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) F3L20_03565 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 F3L20_03570 ENOG4108097 ATP-binding protein F3L20_03590 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) F3L20_03615 ENOG4105CHP RNA polymerase F3L20_03640 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) F3L20_03645 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) F3L20_03665 ENOG4105EMU Dehydrogenase F3L20_03675 ENOG4105DND Transcriptional regulator F3L20_03680 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) F3L20_03685 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_03690 ENOG4108MMM RNA Polymerase F3L20_03700 ENOG4107QVP Dehydrogenase F3L20_03705 ENOG4107QQG Dehydrogenase F3L20_03710 ENOG4105C6V Glycerol-3-phosphate dehydrogenase F3L20_03730 ENOG4108UGD Serine Threonine protein kinase F3L20_03740 ENOG4105C26 Dehydrogenase F3L20_03760 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) F3L20_03805 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_03810 ENOG4105K4H Nlp p60 protein F3L20_03820 ENOG4106611 bacteriocin immunity F3L20_03835 ENOG4105DR5 peptidase F3L20_03860 ENOG4105KKX ATPase associated with various cellular activities aaa_5 F3L20_03870 ENOG4105DEG Vwa containing coxe family protein F3L20_03880 ENOG4105CMV Succinyl-CoA synthetase subunit beta F3L20_03910 ENOG4105DC1 bifunctional purine biosynthesis protein purh F3L20_03920 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) F3L20_03935 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) F3L20_03955 ENOG4105C26 Dehydrogenase F3L20_03970 ENOG4108HQS Glycine betaine F3L20_03980 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) F3L20_03985 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F3L20_03995 ENOG4106032 Glutathionylspermidine synthase F3L20_04000 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) F3L20_04015 ENOG4105EMN RNA polymerase sigma factor F3L20_04020 ENOG4105C31 Tryptophanyl-tRNA synthetase F3L20_04070 ENOG4107RN3 metallophosphoesterase F3L20_04075 ENOG4105BZU Histidine kinase F3L20_04080 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L20_04085 ENOG4105EYF MMPL domain protein F3L20_04115 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_04130 ENOG4108J01 L-aspartate oxidase F3L20_04150 ENOG4105E2D ec 3.2.1.52 F3L20_04205 ENOG4108NIW Leucine export protein LeuE F3L20_04210 ENOG4107SCK Monooxygenase F3L20_04225 ENOG4107QRS glycosyltransferase group 2 family protein F3L20_04240 ENOG4105K64 Glycosyl transferase, family 2 F3L20_04250 ENOG4105F0R Cytidylyltransferase F3L20_04255 ENOG4105D2T synthase F3L20_04265 ENOG4107RM1 amidohydrolase F3L20_04270 ENOG4105DIH basic membrane F3L20_04275 ENOG4105DIH basic membrane F3L20_04280 ENOG4108JQ9 ABC transporter F3L20_04285 ENOG4105UIB (ABC) transporter F3L20_04320 ENOG4105D94 Major Facilitator Superfamily F3L20_04325 ENOG4107RSM transcriptional regulator F3L20_04335 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) F3L20_04360 ENOG41065SU Two-component system sensor kinase F3L20_04365 ENOG4108KXV response regulator F3L20_04370 ENOG4105NAF rna polymerase sigma factor F3L20_04390 ENOG4105C26 Dehydrogenase F3L20_04395 ENOG4105C26 Dehydrogenase F3L20_04410 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain F3L20_04435 ENOG4108JIK carboxylase F3L20_04445 ENOG4107WR6 Maf-like protein F3L20_04455 ENOG4105D8K carboxyl transferase F3L20_04465 ENOG4108QER Adenylate cyclase F3L20_04470 ENOG4105E39 Enoyl-CoA hydratase F3L20_04475 ENOG4105KDM Diguanylate cyclase with gaf sensor F3L20_04480 ENOG4105C84 Histidine ammonia-lyase F3L20_04510 ENOG4105DQ4 alcohol dehydrogenase F3L20_04520 ENOG4108762 serine threonine protein kinase F3L20_04545 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) F3L20_04550 ENOG4105C7B Threonine dehydratase F3L20_04565 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) F3L20_04575 ENOG4105T1M mycothiol conjugate amidase mca F3L20_04590 ENOG4105C7Z Conserved Protein F3L20_04610 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) F3L20_04635 ENOG4105CHM Aminotransferase F3L20_04665 ENOG4108FUF Transcriptional regulator, IclR family F3L20_04670 ENOG4105KME endoribonuclease L-psp F3L20_04675 ENOG4105C6Z Gluconate F3L20_04720 ENOG4107QMS site-determining protein F3L20_04750 ENOG4105RAK Histidine kinase F3L20_04755 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_04810 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) F3L20_04815 ENOG4108IAB Phoh family F3L20_04835 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) F3L20_04840 ENOG4105D3R alkyl hydroperoxide reductase F3L20_04855 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) F3L20_04875 ENOG4105BZ4 penicillin-binding protein F3L20_04890 ENOG4105C9Q fumarate hydratase class II F3L20_04900 ENOG4107GFK fumarate F3L20_04910 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) F3L20_04925 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) F3L20_04945 ENOG4105DFK Polyphosphate glucokinase F3L20_04955 ENOG4105C3G gtp-binding protein F3L20_04960 ENOG4105C0D helicase F3L20_04975 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin F3L20_05015 ENOG4105E33 succinate dehydrogenase F3L20_05020 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) F3L20_05035 ENOG4107USK Extracellular solute-binding protein, family 5 F3L20_05040 ENOG4105CI3 gtp-binding protein typa F3L20_05045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F3L20_05050 ENOG4105DEF Extracellular solute-binding protein, family 5 F3L20_05065 ENOG4108JQ7 (ABC) transporter F3L20_05075 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F3L20_05080 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F3L20_05085 ENOG4105C3U ABC transporter F3L20_05090 ENOG4108JQ7 (ABC) transporter F3L20_05105 ENOG4105DV0 amidase (EC 3.5.1.4 F3L20_05125 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein F3L20_05155 ENOG4108M15 ABC transporter F3L20_05165 ENOG4108ZGX Histidine kinase F3L20_05170 ENOG4108S01 response regulator F3L20_05185 ENOG4108Z4U Ferredoxin F3L20_05205 ENOG4107R4C succinyl-diaminopimelate desuccinylase F3L20_05210 ENOG4108URH decarboxylase F3L20_05225 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) F3L20_05230 ENOG4105CGU Enoyl-CoA hydratase F3L20_05245 ENOG4105DU6 RNA polymerase F3L20_05255 ENOG4105C0H protease F3L20_05260 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) F3L20_05295 ENOG4105D7N magnesium and cobalt transport protein CorA F3L20_05305 ENOG4105DXB Major Facilitator superfamily F3L20_05320 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein F3L20_05340 ENOG4105C1J atp-dependent rna helicase F3L20_05410 ENOG4106JDR secreted F3L20_05415 ENOG4106JDR secreted F3L20_05435 ENOG4105C4R Atp-dependent dna helicase F3L20_05440 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) F3L20_05445 ENOG4105E09 nadh pyrophosphatase F3L20_05465 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) F3L20_05530 ENOG41063PX domain protein F3L20_05540 ENOG4105DJZ UPF0182 protein F3L20_05575 ENOG4107TK4 histidinol-phosphate phosphatase F3L20_05585 ENOG4105KPY Small multidrug resistance protein F3L20_05595 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase F3L20_05605 ENOG4108RAV Conserved protein F3L20_05615 ENOG4105EMN RNA polymerase sigma factor F3L20_05620 ENOG4105WMN AntiSigma factor F3L20_05640 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) F3L20_05650 ENOG41068W2 Cytochrome p-450 F3L20_05655 ENOG4105ECQ AraC Family Transcriptional Regulator F3L20_05665 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F3L20_05690 ENOG4105FDP GntR family transcriptional regulator F3L20_05695 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) F3L20_05710 ENOG4105CBD Diacylglycerol kinase F3L20_05750 ENOG4105ESN nucleotide-binding protein F3L20_05760 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) F3L20_05770 ENOG4105ECQ AraC Family Transcriptional Regulator F3L20_05775 ENOG4108VEQ Superoxide dismutase F3L20_05790 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) F3L20_05795 ENOG4105CDA abc transporter atp-binding protein F3L20_05800 ENOG4105E5Q amino acid AbC transporter F3L20_05815 ENOG4105C6K Malic enzyme F3L20_05820 ENOG4105CB2 alcohol dehydrogenase F3L20_05850 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 F3L20_05860 ENOG4105EB3 Histidine kinase F3L20_05865 ENOG4108PYU two-component system response regulator F3L20_05875 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) F3L20_05920 ENOG4105ZXU NLP P60 protein F3L20_05940 ENOG4105CJN penicillin-binding protein F3L20_05965 ENOG4105DQE DNA ligase F3L20_05970 ENOG4105FDF Could be involved in DNA repair (By similarity) F3L20_05975 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F3L20_05980 ENOG4105EMN RNA polymerase sigma factor F3L20_05990 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_05995 ENOG4105BZU Histidine kinase F3L20_06005 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component F3L20_06015 ENOG4105E0S extracellular solute-binding protein family 1 F3L20_06020 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) F3L20_06050 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F3L20_06055 ENOG4105C75 arginyL-tRNA synthetase F3L20_06060 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) F3L20_06065 ENOG4105D6E homoserine dehydrogenase F3L20_06070 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) F3L20_06085 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap F3L20_06090 ENOG4105VFB Binds the 23S rRNA (By similarity) F3L20_06095 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) F3L20_06100 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) F3L20_06110 ENOG4107ZF2 Phosphatase F3L20_06120 ENOG4105ESV Glycosyl transferase, family 4 F3L20_06125 ENOG4105Z3P ATP synthase F3L20_06135 ENOG4105ZA1 atp synthase F3L20_06140 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) F3L20_06145 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) F3L20_06150 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) F3L20_06155 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) F3L20_06160 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) F3L20_06165 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) F3L20_06180 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_06185 ENOG4105BZU Histidine kinase F3L20_06195 ENOG4105EMU Dehydrogenase F3L20_06220 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase F3L20_06235 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) F3L20_06290 ENOG4105CHU acetyl-coa acetyltransferase F3L20_06310 ENOG4106F60 Histidine kinase F3L20_06350 ENOG4105WX6 Membrane F3L20_06395 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) F3L20_06400 ENOG4105C6K Malic enzyme F3L20_06405 ENOG4105CTQ phosphohexokinase F3L20_06415 ENOG4108MRH transcriptional regulatory protein F3L20_06420 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism F3L20_06425 ENOG4107QJT sodium dicarboxylate symporter F3L20_06445 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) F3L20_06450 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) F3L20_06465 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) F3L20_06485 ENOG4105BZ1 (ABC) transporter F3L20_06490 ENOG4105BZ1 (ABC) transporter F3L20_06500 ENOG4105BZ1 (ABC) transporter F3L20_06505 ENOG4105BZ1 (ABC) transporter F3L20_06510 ENOG4105CJ1 ABC, transporter F3L20_06520 ENOG4105BZU Histidine kinase F3L20_06525 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_06560 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) F3L20_06565 ENOG4107YXZ hydrolase, family 25 F3L20_06575 ENOG4105EJQ L-serine dehydratase F3L20_06580 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) F3L20_06585 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) F3L20_06590 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) F3L20_06615 ENOG4108J59 Extracellular solute-binding protein, family 5 F3L20_06620 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F3L20_06635 ENOG4105EN6 Membrane F3L20_06670 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) F3L20_06690 ENOG4105EMU Dehydrogenase F3L20_06700 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) F3L20_06705 ENOG4105BZU Histidine kinase F3L20_06710 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) F3L20_06715 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) F3L20_06725 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) F3L20_06740 ENOG4105EYF MMPL domain protein F3L20_06745 ENOG4105D9U N-acetyltransferase F3L20_06760 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_06775 ENOG4105CPC Aldo Keto reductase F3L20_06795 ENOG4108ZP8 Acetolactate synthase small subunit F3L20_06800 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase F3L20_06805 ENOG4108JQ1 Dehydrogenase F3L20_06810 ENOG4105C57 major facilitator superfamily F3L20_06820 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR F3L20_06830 ENOG4105C26 Dehydrogenase F3L20_06840 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) F3L20_06845 ENOG4105CM2 brancheD-chain amino acid aminotransferase F3L20_06860 ENOG4105CQM Urea amidohydrolase subunit alpha F3L20_06865 ENOG4105DWY Agmatine deiminase F3L20_06880 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) F3L20_06895 ENOG4105EPH radical SAM domain protein F3L20_06900 ENOG4108W6C Dehydrogenase F3L20_06905 ENOG4105D8K carboxyl transferase F3L20_06925 ENOG4105GWZ Roadblock lc7 family protein F3L20_06945 ENOG4105GWZ Roadblock lc7 family protein F3L20_06960 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase F3L20_06965 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) F3L20_07005 ENOG41069M3 Transcriptional regulator F3L20_07010 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) F3L20_07015 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) F3L20_07025 ENOG4105K70 DNA-binding protein F3L20_07035 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) F3L20_07045 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase F3L20_07050 ENOG4105CPF Cell wall formation (By similarity) F3L20_07070 ENOG4105DWF phosphomethylpyrimidine kinase F3L20_07075 ENOG4105VB9 50S ribosomal protein l28 F3L20_07080 ENOG4105DP4 dak2 domain fusion protein ylov F3L20_07090 ENOG4106H78 methyltransferase F3L20_07095 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) F3L20_07110 ENOG41084BZ 50S ribosomal protein L32 F3L20_07115 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) F3L20_07120 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) F3L20_07125 ENOG4105KVH Transcriptional regulator F3L20_07130 ENOG4105K4I Scp-like extracellular F3L20_07135 ENOG4108375 Acylphosphatase (EC 3.6.1.7) F3L20_07145 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) F3L20_07180 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) F3L20_07200 ENOG4105K5M 30s ribosomal protein S16 F3L20_07205 ENOG41082KU UPF0109 protein F3L20_07210 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) F3L20_07215 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) F3L20_07220 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) F3L20_07235 ENOG4107QYR Signal peptidase i F3L20_07245 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) F3L20_07255 ENOG41080R2 UPF0102 protein F3L20_07260 ENOG4105C0P Mg chelatase subunit ChlI F3L20_07285 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F3L20_07300 ENOG4105CFF transcriptional regulator F3L20_07350 ENOG4108C33 Resolvase F3L20_07355 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L20_07365 ENOG41063SB peptidase F3L20_07370 ENOG4105CE9 30S ribosomal protein S2 F3L20_07375 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) F3L20_07380 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) F3L20_07385 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) F3L20_07390 ENOG4105KNE Phosphatidate cytidylyltransferase F3L20_07400 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs F3L20_07410 ENOG4108I5D sulfate abc transporter F3L20_07415 ENOG4108UCS ABC, transporter F3L20_07440 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) F3L20_07445 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F3L20_07455 ENOG4105C26 Dehydrogenase F3L20_07470 ENOG4108QXE glycerophosphoryl diester phosphodiesterase F3L20_07475 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) F3L20_07500 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F3L20_07505 ENOG4105F38 ABC transporter, permease F3L20_07510 ENOG4105D38 putrescine abc transporter F3L20_07515 ENOG4105CJP fad dependent oxidoreductase F3L20_07540 ENOG4105G9B Transcriptional regulator F3L20_07560 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) F3L20_07565 ENOG4105DZP Membrane-associated zinc metalloprotease F3L20_07570 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) F3L20_07585 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) F3L20_07600 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase F3L20_07615 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) F3L20_07630 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) F3L20_07640 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) F3L20_07645 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) F3L20_07670 ENOG4105C3U ABC transporter F3L20_07680 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F3L20_07685 ENOG4105DEF Extracellular solute-binding protein, family 5 F3L20_07705 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) F3L20_07710 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) F3L20_07715 ENOG4105C1V Peptidase, M16 F3L20_07720 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) F3L20_07745 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F3L20_07750 ENOG4105CN5 Metallo-Beta-Lactamase F3L20_07795 ENOG4105BZU Histidine kinase F3L20_07800 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase F3L20_07815 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) F3L20_07825 ENOG4105CEV competence damage-inducible protein F3L20_07830 ENOG4105WBV Transcriptional regulator F3L20_07835 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction F3L20_07845 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) F3L20_07850 ENOG4107QRT dEAD DEAH box helicase F3L20_07855 ENOG4106AXJ AraC family transcriptional regulator F3L20_07880 ENOG4105DSF transport protein F3L20_07890 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) F3L20_07900 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) F3L20_07915 ENOG4105DRP amino acid AbC transporter F3L20_07920 ENOG4108Q1T ABC transporter F3L20_07925 ENOG4107UBR Extracellular solute-binding protein family 3 F3L20_07930 ENOG4105CDA abc transporter atp-binding protein F3L20_07935 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L20_07940 ENOG4105EB3 Histidine kinase F3L20_07960 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) F3L20_07980 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) F3L20_07990 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) F3L20_07995 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) F3L20_08005 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) F3L20_08020 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) F3L20_08025 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) F3L20_08030 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F3L20_08050 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) F3L20_08070 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) F3L20_08085 ENOG4105C9U ATP-dependent DNA helicase RecQ F3L20_08095 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) F3L20_08105 ENOG4105DRR Transcriptional regulator, GntR family F3L20_08110 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L20_08115 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap F3L20_08125 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F3L20_08135 ENOG4107QN1 sodium solute F3L20_08140 ENOG4108V9W transcriptional regulatory protein F3L20_08170 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F3L20_08190 ENOG4105DRR Transcriptional regulator, GntR family F3L20_08195 ENOG410849S phosphocarrier protein (HPr) F3L20_08205 ENOG4105CD5 CoA-binding domain protein F3L20_08220 ENOG4107W53 thymidine kinase F3L20_08230 ENOG4105KVH Transcriptional regulator F3L20_08275 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) F3L20_08295 ENOG4105E98 transcriptional regulator DeoR family F3L20_08300 ENOG4105E9Z Nad-dependent epimerase dehydratase F3L20_08325 ENOG4105DRR Transcriptional regulator, GntR family F3L20_08340 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component F3L20_08345 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component F3L20_08360 ENOG4105E4I Glycoside hydrolase family 28 F3L20_08370 ENOG4108J20 pectate lyase F3L20_08375 ENOG4105NBR Pectinesterase F3L20_08385 ENOG4105C7N Xanthine uracil vitamin C permease F3L20_08400 ENOG4105CJN penicillin-binding protein F3L20_08410 ENOG4107HP6 Transcriptional regulator F3L20_08420 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_08425 ENOG4105BZU Histidine kinase F3L20_08445 ENOG4105C9B Cysteine desulfurase F3L20_08450 ENOG4105EV8 ectoine hydroxylase F3L20_08455 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) F3L20_08460 ENOG4108JPW Aminotransferase F3L20_08465 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase F3L20_08475 ENOG4105C5R Aminotransferase F3L20_08480 ENOG4106PMH Extracellular solute-binding protein family 3 F3L20_08485 ENOG4105EAD ABC transporter F3L20_08490 ENOG4105CDA abc transporter atp-binding protein F3L20_08510 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein F3L20_08515 ENOG41081F0 Precorrin-8x methylmutase F3L20_08520 ENOG4105E4R Precorrin-3B C17-methyltransferase F3L20_08530 ENOG4105CIA precorrin-4 C(11)-methyltransferase F3L20_08550 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase F3L20_08560 ENOG4105CTK cobaltochelatase, cobn subunit F3L20_08565 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) F3L20_08570 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) F3L20_08585 ENOG4107W7X Aldolase F3L20_08605 ENOG4105C5H ABC transporter F3L20_08655 ENOG4105BZP glycoside hydrolase 15-related F3L20_08685 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) F3L20_08695 ENOG410846T CoA-transferase family III F3L20_08715 ENOG4107QN1 sodium solute F3L20_08720 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) F3L20_08740 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) F3L20_08755 ENOG4105CHR reductase F3L20_08770 ENOG4105JXH GntR family transcriptional regulator F3L20_08790 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) F3L20_08795 ENOG4105EAC phosphoserine phosphatase F3L20_08805 ENOG4105IDI abc transporter atp-binding protein F3L20_08815 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) F3L20_08825 ENOG4108XG2 Histidine kinase F3L20_08830 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_08840 ENOG4108UF8 F3L20_08845 ENOG4105DKW ABC transporter F3L20_08865 ENOG4108V1U phospholipid-binding protein F3L20_08875 ENOG4108VX5 3-methyladenine DNA glycosylase F3L20_08910 ENOG4105DSU hydrolase F3L20_08915 ENOG4105DQ5 transport system permease protein F3L20_08920 ENOG4105TVJ transport system, permease F3L20_08925 ENOG4105E0A ABC, transporter F3L20_08945 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) F3L20_08950 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) F3L20_08955 ENOG4107QPH glycogen) synthase F3L20_08965 ENOG4105BZP glycoside hydrolase 15-related F3L20_08970 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) F3L20_08985 ENOG4105DCF alanine dehydrogenase F3L20_09000 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) F3L20_09005 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) F3L20_09010 ENOG4105FE9 pseudouridine synthase F3L20_09020 ENOG41065RQ ADP-ribosylation crystallin J1 F3L20_09025 ENOG410756H nucleotidyltransferase F3L20_09035 ENOG4108UDB Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) F3L20_09050 ENOG4105CAT Cytidine monophosphate kinase F3L20_09060 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) F3L20_09080 ENOG410841Q phosphoesterase PA-phosphatase related protein F3L20_09090 ENOG4105C57 major facilitator superfamily F3L20_09095 ENOG4105C1G acyl-Coa dehydrogenase F3L20_09100 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) F3L20_09110 ENOG4106NMR serine protease F3L20_09125 ENOG4105C0B DNA polymerase III (alpha subunit) F3L20_09180 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family F3L20_09195 ENOG4108TCJ secreted hydrolase F3L20_09200 ENOG4105D9P serine threonine protein kinase F3L20_09220 ENOG4105K6V RNA polymerase F3L20_09225 ENOG4105RNG membrane F3L20_09260 ENOG4105FDP GntR family transcriptional regulator F3L20_09265 ENOG4105F1J Homogentisate 1,2-dioxygenase F3L20_09275 ENOG4108SGK Tetr family transcriptional regulator F3L20_09280 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) F3L20_09285 ENOG4105D4T Citrate transporter F3L20_09330 ENOG4108ZHR arsR family transcriptional regulator F3L20_09340 ENOG4105C1G acyl-Coa dehydrogenase F3L20_09360 ENOG4108Z4X TRANSCRIPTIONal F3L20_09375 ENOG4105EHZ conserved protein UCP016719 F3L20_09380 ENOG4105CHR reductase F3L20_09385 ENOG4108IG5 Transcriptional regulator F3L20_09400 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein F3L20_09410 ENOG4105VG5 Membrane F3L20_09415 ENOG4105PTV Nudix Hydrolase F3L20_09440 ENOG4105C6Z Gluconate F3L20_09450 ENOG4105C6F GntR Family Transcriptional Regulator F3L20_09455 ENOG4105K5B UPF0225 protein F3L20_09465 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) F3L20_09475 ENOG4105S2J secreted protein F3L20_09495 ENOG4105CPC Aldo Keto reductase F3L20_09500 ENOG4105DYW oxidoreductase F3L20_09510 ENOG4105D7N magnesium and cobalt transport protein CorA F3L20_09530 ENOG4105C8N cysteinyl-tRNA synthetase F3L20_09540 ENOG4105C6V Glycerol-3-phosphate dehydrogenase F3L20_09545 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) F3L20_09550 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) F3L20_09560 ENOG4105C3R Methionine synthase F3L20_09565 ENOG4107URF beta-phospho-glucomutase F3L20_09570 ENOG4108J59 Extracellular solute-binding protein, family 5 F3L20_09575 ENOG4108J59 Extracellular solute-binding protein, family 5 F3L20_09580 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_09615 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) F3L20_09620 ENOG4105E5F proteasome F3L20_09625 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) F3L20_09635 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) F3L20_09640 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) F3L20_09655 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) F3L20_09660 ENOG4108V1T peptidylprolyl cis-trans isomerase F3L20_09690 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) F3L20_09695 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) F3L20_09735 ENOG4105D3G Pseudouridine synthase F3L20_09745 ENOG4105HFS 5'-3' exonuclease F3L20_09750 ENOG4108IJ7 Glycine betaine F3L20_09755 ENOG4108HQS Glycine betaine F3L20_09775 ENOG4108Z86 Glutamine amidotransferase F3L20_09780 ENOG4105CUB amino acid F3L20_09845 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) F3L20_09850 ENOG41084BS 50S ribosomal protein L35 F3L20_09855 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) F3L20_09860 ENOG4108RWN rrna methyltransferase F3L20_09865 ENOG4105BZU Histidine kinase F3L20_09870 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) F3L20_09875 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) F3L20_09890 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) F3L20_09900 ENOG4105F32 YngK protein F3L20_09940 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase F3L20_09945 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) F3L20_09950 ENOG4105CAS nag kinase F3L20_09955 ENOG4105C8Y Acetylornithine aminotransferase F3L20_09960 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) F3L20_09995 ENOG4105CDH Citrulline--aspartate ligase F3L20_10000 ENOG4105CH7 arginosuccinase F3L20_10010 ENOG4105RJZ Transcriptional regulator F3L20_10015 ENOG4105C57 major facilitator superfamily F3L20_10020 ENOG4105CEY Amp-dependent synthetase and ligase F3L20_10025 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase F3L20_10055 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) F3L20_10060 ENOG4108UMI ABC transporter, permease F3L20_10065 ENOG4105D01 (LipO)protein F3L20_10085 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) F3L20_10150 ENOG4105F0I Aminotransferase F3L20_10175 ENOG4105KF0 sporulation and cell division protein, SsgA F3L20_10205 ENOG4108IRC dna polymerase iii F3L20_10220 ENOG4105C22 threonyL-tRNA synthetase F3L20_10240 ENOG4108VTU Cdp-alcohol phosphatidyltransferase F3L20_10245 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase F3L20_10250 ENOG4105E2K Glycosyl transferase (Group 1 F3L20_10260 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) F3L20_10265 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) F3L20_10270 ENOG4105CDY transcriptional regulatory protein F3L20_10275 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) F3L20_10280 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) F3L20_10285 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) F3L20_10295 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) F3L20_10300 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) F3L20_10305 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) F3L20_10315 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) F3L20_10320 ENOG4105C99 atpase involved in dna repair F3L20_10325 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) F3L20_10335 ENOG4105CUT histidyl-tRNA synthetase F3L20_10350 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) F3L20_10365 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) F3L20_10370 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) F3L20_10385 ENOG4105E2X shikimate dehydrogenase F3L20_10395 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase F3L20_10400 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) F3L20_10405 ENOG4105D49 3-dehydroquinate synthase F3L20_10415 ENOG4105DC7 peptidase M24 F3L20_10420 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) F3L20_10425 ENOG410803B Involved in the transcription termination process (By similarity) F3L20_10435 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) F3L20_10440 ENOG4105CXT aspartate transcarbamylase F3L20_10445 ENOG4105CD3 dihydroorotase F3L20_10455 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain F3L20_10465 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) F3L20_10470 ENOG4105SKN orotidine 5''-phosphate decarboxylase F3L20_10480 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) F3L20_10485 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) F3L20_10495 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP F3L20_10510 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) F3L20_10520 ENOG4105DJV ribulose-phosphate 3-epimerase F3L20_10525 ENOG4105DKT Transcriptional regulator F3L20_10545 ENOG4105CUB amino acid F3L20_10560 ENOG4108ZJ4 polysaccharide deacetylase F3L20_10570 ENOG4105KVH Transcriptional regulator F3L20_10595 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) F3L20_10600 ENOG4105C2W permease F3L20_10610 ENOG4106UW1 Major Facilitator superfamily F3L20_10615 ENOG4105E2R ROK family F3L20_10635 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) F3L20_10640 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) F3L20_10645 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase F3L20_10650 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) F3L20_10700 ENOG4105C1G acyl-Coa dehydrogenase F3L20_10715 ENOG4105EW9 transcriptional regulator AsnC family F3L20_10725 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) F3L20_10730 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 F3L20_10735 ENOG4105Q70 F3L20_10740 ENOG4105DEU major facilitator superfamily F3L20_10750 ENOG4108VW9 Membrane F3L20_10755 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F3L20_10770 ENOG4105JXB ankyrin repeat-containing protein F3L20_10780 ENOG4107R7A Allophanate hydrolase subunit 2 F3L20_10785 ENOG4105P4J Allophanate hydrolase, subunit 1 F3L20_10790 ENOG4105E7W lamb ycsf family protein F3L20_10795 ENOG4105CFM UPF0317 protein F3L20_10800 ENOG4107RGD Major Facilitator superfamily F3L20_10825 ENOG41069M3 Transcriptional regulator F3L20_10840 ENOG4105GWZ Roadblock lc7 family protein F3L20_10860 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) F3L20_10865 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) F3L20_10870 ENOG4108UQS dipeptidase F3L20_10885 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) F3L20_10895 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) F3L20_10950 ENOG4108UW8 fha domain-containing protein F3L20_10970 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) F3L20_10980 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor F3L20_11000 ENOG4105X1Q TOBE domain protein F3L20_11025 ENOG4105JAB phenazine biosynthesis protein, phzf family F3L20_11060 ENOG4105CSW GntR family transcriptional regulator F3L20_11065 ENOG4108Q5Y Membrane F3L20_11105 ENOG4105CHR reductase F3L20_11115 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) F3L20_11150 ENOG4105EP9 oxidoreductase F3L20_11155 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) F3L20_11165 ENOG4105CYX Short-chain dehydrogenase reductase Sdr F3L20_11175 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) F3L20_11180 ENOG4107YPT transcriptional regulator F3L20_11185 ENOG4105CHU acetyl-coa acetyltransferase F3L20_11200 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) F3L20_11230 ENOG4108Z0R Transferase F3L20_11235 ENOG4108UW5 maltose o-acetyltransferase F3L20_11255 ENOG4105K4P CoA-binding domain protein F3L20_11270 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein F3L20_11280 ENOG4105EYH Exonuclease F3L20_11300 ENOG4108PSK reductase F3L20_11350 ENOG4106HB6 Alpha beta hydrolase F3L20_11355 ENOG4108KPJ rna polymerase sigma factor F3L20_11360 ENOG4105FDP GntR family transcriptional regulator F3L20_11365 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) F3L20_11385 ENOG4108VCA G U mismatch-specific DNA glycosylase F3L20_11390 ENOG4105C83 adenylosuccinate lyase F3L20_11415 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) F3L20_11440 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) F3L20_11445 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F3L20_11450 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) F3L20_11500 ENOG4108Q5F Tetr family transcriptional regulator F3L20_11505 ENOG4108YZ9 Urea amidohydrolase subunit gamma F3L20_11510 ENOG4105KI2 Urea amidohydrolase subunit beta F3L20_11515 ENOG4105CQM Urea amidohydrolase subunit alpha F3L20_11525 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) F3L20_11540 ENOG4105F6E Acyl-transferase F3L20_11545 ENOG4108YZG isomerase F3L20_11560 ENOG4105F44 Two component transcriptional regulator, winged helix family F3L20_11565 ENOG4106F60 Histidine kinase F3L20_11590 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) F3L20_11600 ENOG4107WMG L,D-carboxypeptidase F3L20_11610 ENOG4105C19 ABC transporter F3L20_11640 ENOG4107VEG TrkA-N domain protein F3L20_11645 ENOG4105C0X amino acid F3L20_11650 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) F3L20_11720 ENOG41082AN stage II sporulation protein F3L20_11740 ENOG4105CVP deoxyribo-dipyrimidine photolyase F3L20_11750 ENOG4105DTD Dehydrogenase F3L20_11775 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase F3L20_11790 ENOG4105K64 Glycosyl transferase, family 2 F3L20_11845 ENOG4107RRD Dehydrogenase F3L20_11850 ENOG4105CAQ asparagine synthetase F3L20_11870 ENOG4105C6Y Udp-glucose 6-dehydrogenase F3L20_11885 ENOG4105EC3 peptidase S51, dipeptidase E F3L20_11890 ENOG4105FDP GntR family transcriptional regulator F3L20_11900 ENOG4105D56 permease protein F3L20_11910 ENOG4105D17 glycoside hydrolase, family 3 domain protein F3L20_11955 ENOG4107S1Q Phosphatase F3L20_11960 ENOG4105CEU Arginine dihydrolase F3L20_11965 ENOG4105DBV ornithine carbamoyltransferase F3L20_11975 ENOG4105CGU Enoyl-CoA hydratase F3L20_12035 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) F3L20_12040 ENOG4108TCJ secreted hydrolase F3L20_12050 ENOG4107RSM transcriptional regulator F3L20_12060 ENOG4106UW1 Major Facilitator superfamily F3L20_12065 ENOG4108RFG Tetr family transcriptional regulator F3L20_12070 ENOG4108JJB ABC transporter F3L20_12085 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) F3L20_12100 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F3L20_12110 ENOG4105C3U ABC transporter F3L20_12115 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) F3L20_12165 ENOG4107QN1 sodium solute F3L20_12180 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) F3L20_12190 ENOG4107QM5 aconitate hydratase F3L20_12220 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component F3L20_12230 ENOG4105E2R ROK family F3L20_12235 ENOG4105DFW ABC transporter F3L20_12240 ENOG4105C2J ABC transporter F3L20_12245 ENOG4107RNG ABC transporter F3L20_12250 ENOG4105N14 lysine exporter protein LysE YggA F3L20_12255 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) F3L20_12260 ENOG4105CUB amino acid F3L20_12275 ENOG4107TB5 TRANSCRIPTIONal F3L20_12285 ENOG4105C39 capsular polysaccharide phosphotransferase F3L20_12295 ENOG4108I69 Glycosyl transferases group 1 F3L20_12305 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase F3L20_12310 ENOG4105CHU acetyl-coa acetyltransferase F3L20_12325 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) F3L20_12340 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) F3L20_12345 ENOG4107FKK extracellular solute-binding protein family 1 F3L20_12350 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component F3L20_12355 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component F3L20_12370 ENOG4105DSG hydrolase family 43 F3L20_12385 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase F3L20_12395 ENOG4105C1Q protoporphyrinogen oxidase F3L20_12400 ENOG4107JTW chlorite dismutase F3L20_12420 ENOG4105E18 UPF0276 protein F3L20_12425 ENOG4107R72 Ceramidase F3L20_12440 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth F3L20_12485 ENOG4105DFU Cell wall formation (By similarity) F3L20_12490 ENOG4105E0X reductase F3L20_12530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L20_12535 ENOG4105BZU Histidine kinase F3L20_12545 ENOG4105BZU Histidine kinase F3L20_12550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L20_12555 ENOG4108IJ8 ABC transporter F3L20_12560 ENOG4105E90 ABC transporter F3L20_12565 ENOG4105E90 ABC transporter F3L20_12600 ENOG41064MX Tetr family transcriptional regulator F3L20_12610 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein F3L20_12620 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) F3L20_12735 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) F3L20_12740 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) F3L20_12765 ENOG4107RR1 TRANSCRIPTIONal F3L20_12770 ENOG4105CSU acyl-Coa dehydrogenase F3L20_12785 ENOG4105E7U AraC family transcriptional regulator F3L20_12815 ENOG4105C5Q Transcriptional regulator F3L20_12825 ENOG4105EBR Carboxylesterase F3L20_12860 ENOG4108J5H Homocysteine s-methyltransferase F3L20_12865 ENOG41086KC Transcriptional regulator F3L20_12895 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) F3L20_12920 ENOG4105QE3 oxidoreductase F3L20_12930 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) F3L20_12945 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) F3L20_12950 ENOG4108Z6Z Transcriptional regulator F3L20_12965 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) F3L20_12980 ENOG4105C7K acetolactate synthase F3L20_13040 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding F3L20_13045 ENOG4105C7N Xanthine uracil vitamin C permease F3L20_13075 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase F3L20_13080 ENOG4105DKP glycosyl transferase, family 9 F3L20_13130 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) F3L20_13135 ENOG4105CEY Amp-dependent synthetase and ligase F3L20_13140 ENOG4108W5M transcriptional regulator F3L20_13145 ENOG4105CHR reductase F3L20_13155 ENOG4105XYF acetyltransferase F3L20_13165 ENOG41060W2 glyoxylate carboligase F3L20_13180 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase F3L20_13185 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) F3L20_13205 ENOG4105VT2 5-hydroxyisourate hydrolase F3L20_13215 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) F3L20_13295 ENOG4105CHM Aminotransferase F3L20_13325 ENOG4105DUU IucA IucC family protein F3L20_13335 ENOG4105DU1 integral membrane protein, terc F3L20_13350 ENOG4107R9S Malate synthase F3L20_13365 ENOG4107HP6 Transcriptional regulator F3L20_13375 ENOG4105DHG Allantoate amidinohydrolase F3L20_13400 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_13410 ENOG4106448 streptomycin biosynthesis protein strI F3L20_13415 ENOG4105FDP GntR family transcriptional regulator F3L20_13420 ENOG4105DKQ ROK family F3L20_13430 ENOG4105C0D helicase F3L20_13465 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase F3L20_13470 ENOG4105E8R UPF0173 metal-dependent hydrolase F3L20_13475 ENOG4105CGK Exodeoxyribonuclease III F3L20_13485 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) F3L20_13490 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) F3L20_13520 ENOG4105C8Y Acetylornithine aminotransferase F3L20_13535 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) F3L20_13540 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone F3L20_13545 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease F3L20_13570 ENOG4105C3U ABC transporter F3L20_13580 ENOG4105DEF Extracellular solute-binding protein, family 5 F3L20_13590 ENOG4105I82 acetyl xylan esterase F3L20_13600 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F3L20_13610 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) F3L20_13615 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 F3L20_13625 ENOG4105ECY inositol monophosphatase F3L20_13635 ENOG4108UVJ appr-1-p processing domain protein F3L20_13660 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) F3L20_13685 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) F3L20_13710 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme F3L20_13715 ENOG4105C1G acyl-Coa dehydrogenase F3L20_13730 ENOG4105RFZ Methylmalonyl-coA mutase F3L20_13735 ENOG4105EE1 crotonyl-CoA reductase F3L20_13745 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase F3L20_13795 ENOG4105C32 Amino acid ABC transporter (Permease) F3L20_13800 ENOG4108IV0 ABC, transporter F3L20_13805 ENOG4105C0Z ABC transporter F3L20_13815 ENOG4105CHR reductase F3L20_13820 ENOG4108ME1 Peptidase M55 D-aminopeptidase F3L20_13825 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) F3L20_13835 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A F3L20_13860 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone F3L20_13875 ENOG4105DQE DNA ligase F3L20_13885 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth F3L20_13910 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) F3L20_13920 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) F3L20_13925 ENOG4108XNA Gas vesicle F3L20_13935 ENOG4105C5H ABC transporter F3L20_13950 ENOG4108Z0Z intracellular protease Pfpi family F3L20_14030 ENOG4105CFG Acts as a chaperone (By similarity) F3L20_14050 ENOG4106GCT Dehydratase F3L20_14060 ENOG4105CYP glycoside hydrolase, family F3L20_14065 ENOG41065HY 1,4-beta-cellobiosidase F3L20_14080 ENOG4105CV8 reductase F3L20_14090 ENOG4105EMY transcriptional regulator F3L20_14095 ENOG4105DHU Bile acid F3L20_14100 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) F3L20_14115 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) F3L20_14120 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) F3L20_14130 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) F3L20_14145 ENOG4105C2J ABC transporter F3L20_14150 ENOG4105CNN ABC, transporter F3L20_14155 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator F3L20_14215 ENOG4105FCD Major Facilitator F3L20_14220 ENOG4105CMV Succinyl-CoA synthetase subunit beta F3L20_14235 ENOG4105CMV Succinyl-CoA synthetase subunit beta F3L20_14245 ENOG4105C26 Dehydrogenase F3L20_14305 ENOG4105CSH Transporter F3L20_14310 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) F3L20_14315 ENOG4108IJG ABC transporter substrate-binding protein F3L20_14320 ENOG4105D56 permease protein F3L20_14325 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component F3L20_14340 ENOG4105CYX Short-chain dehydrogenase reductase Sdr F3L20_14355 ENOG4105KKX ATPase associated with various cellular activities aaa_5 F3L20_14360 ENOG4105DEG Vwa containing coxe family protein F3L20_14375 ENOG4108HQ0 Exopolysaccharide biosynthesis protein F3L20_14445 ENOG41061JJ Peptidase family M23 F3L20_14450 ENOG41061AU MarR family Transcriptional regulator F3L20_14475 ENOG4105C26 Dehydrogenase F3L20_14485 ENOG4105C94 Transporter F3L20_14515 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) F3L20_14535 ENOG4107QJN gtp cyclohydrolase ii F3L20_14545 ENOG410905P Pyridoxamine 5-phosphate F3L20_14550 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) F3L20_14555 ENOG4107TB6 phosphoglycerate mutase F3L20_14560 ENOG4108J5G 6-phosphogluconate dehydrogenase F3L20_14580 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) F3L20_14600 ENOG4105F8D glycoside hydrolase family 4 F3L20_14640 ENOG4105MWK D-amino acid dehydrogenase, small subunit F3L20_14650 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein F3L20_14660 ENOG4105CTU Proline racemase F3L20_14680 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component F3L20_14685 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component F3L20_14690 ENOG4105CG3 alpha amylase, catalytic region F3L20_14700 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component F3L20_14710 ENOG4107UWC ABC, transporter F3L20_14730 ENOG4107NHD transcriptional regulator F3L20_14740 ENOG4105CHF Glutathione S-transferase F3L20_14765 ENOG4107SM8 Adenylate Guanylate cyclase F3L20_14770 ENOG4108R5T secreted protein F3L20_14785 ENOG4105DQE DNA ligase F3L20_14805 ENOG4105ETE Transcriptional regulator (LacI family F3L20_14815 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) F3L20_14825 ENOG4106V2I dimethylaminohydrolase F3L20_14830 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) F3L20_14835 ENOG4105C5H ABC transporter F3L20_14845 ENOG4105KF0 sporulation and cell division protein, SsgA F3L20_14860 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) F3L20_14870 ENOG4105EG6 Saccharopine dehydrogenase F3L20_14880 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F F3L20_14885 ENOG4105CHU acetyl-coa acetyltransferase F3L20_14890 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase F3L20_14920 ENOG4105C94 Transporter F3L20_14935 ENOG4105C5H ABC transporter F3L20_14945 ENOG4105E39 Enoyl-CoA hydratase F3L20_14960 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) F3L20_14985 ENOG4108MDK Dehydrogenase F3L20_15005 ENOG4105EY8 ABC transporter F3L20_15010 ENOG4105FBD synthase F3L20_15020 ENOG4107S11 squalene-associated FAD-dependent desaturase F3L20_15030 ENOG4105EWU Squalene--hopene cyclase F3L20_15050 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) F3L20_15080 ENOG41090WU lipolytic protein G-D-S-L family F3L20_15095 ENOG4105VEQ Cold shock protein F3L20_15100 ENOG4105C1J atp-dependent rna helicase F3L20_15115 ENOG4105CN5 Metallo-Beta-Lactamase F3L20_15125 ENOG4105GAK amidohydrolase 2 F3L20_15135 ENOG4105KHM amidohydrolase 2 F3L20_15175 ENOG4105CPQ Dehydrogenase F3L20_15180 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) F3L20_15185 ENOG4106NZI LysR family Transcriptional regulator F3L20_15190 ENOG4108R86 Transcriptional regulator F3L20_15320 ENOG4105FDP GntR family transcriptional regulator F3L20_15325 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) F3L20_15330 ENOG4105DH8 myo-inositol catabolism F3L20_15340 ENOG4105EDK PfkB domain protein F3L20_15350 ENOG4105CNN ABC, transporter F3L20_15355 ENOG4105C2J ABC transporter F3L20_15360 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) F3L20_15365 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) F3L20_15400 ENOG4105CHR reductase F3L20_15420 ENOG41089GP Oxidoreductase domain protein F3L20_15430 ENOG410905P Pyridoxamine 5-phosphate F3L20_15470 ENOG4105E9K Isocitrate dehydrogenase F3L20_15475 ENOG4105D64 Mechanosensitive ion channel F3L20_15480 ENOG4105E39 Enoyl-CoA hydratase F3L20_15490 ENOG4105BZ1 (ABC) transporter F3L20_15495 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) F3L20_15505 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_15510 ENOG4105BZU Histidine kinase F3L20_15540 ENOG4107T94 Endo-14-beta-xylanase F3L20_15555 ENOG4105ETE Transcriptional regulator (LacI family F3L20_15560 ENOG4105XN3 extracellular solute-binding protein family 1 F3L20_15565 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component F3L20_15575 ENOG4107QK4 glycoside hydrolase, family 3 domain protein F3L20_15620 ENOG4105C1J atp-dependent rna helicase F3L20_15640 ENOG4108KPJ rna polymerase sigma factor F3L20_15655 ENOG4105DWV Homoserine O-trans-acetylase F3L20_15670 ENOG4105FBW Monooxygenase F3L20_15700 ENOG4105CHR reductase F3L20_15710 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase F3L20_15740 ENOG4105D2S major facilitator superfamily F3L20_15745 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) F3L20_15750 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) F3L20_15770 ENOG4105D17 glycoside hydrolase, family 3 domain protein F3L20_15780 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) F3L20_15785 ENOG4105EHG Permease protein F3L20_15790 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) F3L20_15800 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) F3L20_15815 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) F3L20_15835 ENOG4107QPH glycogen) synthase F3L20_15840 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) F3L20_15895 ENOG4105C8Y Acetylornithine aminotransferase F3L20_15900 ENOG4107P5I polyketide synthase F3L20_15920 ENOG4107R13 MMPL domain protein F3L20_15970 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase F3L20_15980 ENOG4105WQI isochorismatase F3L20_15985 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase F3L20_15990 ENOG4105CI2 imidazolone-5-propionate hydrolase F3L20_16000 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase F3L20_16025 ENOG4105C57 major facilitator superfamily F3L20_16055 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) F3L20_16070 ENOG4105C1G acyl-Coa dehydrogenase F3L20_16165 ENOG4105CUB amino acid F3L20_16175 ENOG4108ZJ4 polysaccharide deacetylase F3L20_16195 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin F3L20_16220 ENOG4105BZU Histidine kinase F3L20_16225 ENOG4105C5Q Transcriptional regulator F3L20_16240 ENOG4105E33 succinate dehydrogenase F3L20_16250 ENOG4105DEN Luciferase family F3L20_16260 ENOG4105WKW Pfam:DUF1458 F3L20_16270 ENOG41067HS methyltransferase F3L20_16275 ENOG4108V75 Glutamine amidotransferase F3L20_16280 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process F3L20_16305 ENOG4105GTG Isochorismatase F3L20_16315 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) F3L20_16320 ENOG4105EMU Dehydrogenase F3L20_16335 ENOG41080XP Cbs domain F3L20_16350 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F F3L20_16360 ENOG4107RSM transcriptional regulator F3L20_16370 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit F3L20_16375 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding F3L20_16380 ENOG4105C7W Xanthine dehydrogenase F3L20_16400 ENOG41060NJ transcriptional regulator F3L20_16410 ENOG41080RH Thioredoxin F3L20_16465 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) F3L20_16470 ENOG41080R8 Conserved Protein F3L20_16475 ENOG4107QR9 Iron-sulfur cluster binding protein F3L20_16480 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) F3L20_16485 ENOG4105DET Rhamnulokinase F3L20_16500 ENOG4105C2J ABC transporter F3L20_16510 ENOG4105F5R ABC transporter F3L20_16515 ENOG4105D4B ABC, transporter F3L20_16525 ENOG4105ETE Transcriptional regulator (LacI family F3L20_16540 ENOG4108KPJ rna polymerase sigma factor F3L20_16555 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) F3L20_16560 ENOG4108R86 Transcriptional regulator F3L20_16570 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) F3L20_16610 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 F3L20_16615 ENOG4105DCG PHP domain protein F3L20_16620 ENOG4105H9W Short-chain dehydrogenase reductase Sdr F3L20_16655 ENOG4105CHF Glutathione S-transferase F3L20_16685 ENOG4105CPC Aldo Keto reductase F3L20_16715 ENOG4105DMF Dehydrogenase F3L20_16760 ENOG4108JJA ABC, transporter F3L20_16765 ENOG4108JJA ABC, transporter F3L20_16795 ENOG41080XP Cbs domain F3L20_16820 ENOG4105XRQ Xanthine dehydrogenase accessory factor F3L20_16850 ENOG4105EMU Dehydrogenase F3L20_16860 ENOG4106NZI LysR family Transcriptional regulator F3L20_16885 ENOG4105CHR reductase F3L20_16915 ENOG4105C87 Aminotransferase class I and II F3L20_16920 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) F3L20_16940 ENOG4108PYU two-component system response regulator F3L20_16945 ENOG4108FKE two-component system sensor kinase F3L20_16950 ENOG4105DZ1 carboxypeptidase F3L20_17010 ENOG4105C71 hydrolase family 65, central catalytic F3L20_17040 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase F3L20_17045 ENOG4107SET aldo keto reductase F3L20_17050 ENOG4105BZ1 (ABC) transporter F3L20_17060 ENOG4105ECQ AraC Family Transcriptional Regulator F3L20_17195 ENOG4105G9B Transcriptional regulator F3L20_17200 ENOG4108IV0 ABC, transporter F3L20_17205 ENOG4105C0Z ABC transporter F3L20_17210 ENOG4105C32 Amino acid ABC transporter (Permease) F3L20_17230 ENOG4105CPC Aldo Keto reductase F3L20_17245 ENOG4106T9R serine protease F3L20_17270 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) F3L20_17280 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase F3L20_17285 ENOG4107R6F Alpha Beta Hydrolase Fold protein F3L20_17300 ENOG4105C0I Conserved Protein F3L20_17325 ENOG4105E2R ROK family F3L20_17335 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) F3L20_17350 ENOG4105EGE secreted protein F3L20_17365 ENOG4105E0A ABC, transporter F3L20_17370 ENOG4105J76 Periplasmic binding protein F3L20_17375 ENOG4105S6R Iron-hydroxamate transporter permease subunit F3L20_17400 ENOG4105C4C beta-galactosidase F3L20_17410 ENOG4105DRS transport system, permease F3L20_17420 ENOG4105ETE Transcriptional regulator (LacI family F3L20_17445 ENOG4105C1J atp-dependent rna helicase F3L20_17460 ENOG4107SMB hydrolase Family 5 F3L20_17465 ENOG4105EWI Short-chain dehydrogenase reductase Sdr F3L20_17470 ENOG4105CSR polyphosphate kinase 2 F3L20_17475 ENOG4105CJQ hydrolase, family 31 F3L20_17490 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component F3L20_17495 ENOG4105CS2 ec 3.2.1.21 F3L20_17510 ENOG4105CWX Alpha-1,2-mannosidase F3L20_17520 ENOG4105FDP GntR family transcriptional regulator F3L20_17555 ENOG4105EGE secreted protein F3L20_17560 ENOG4107YPT transcriptional regulator F3L20_17585 ENOG4105ETE Transcriptional regulator (LacI family F3L20_17600 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase F3L20_17605 ENOG41082SX arsR family transcriptional regulator F3L20_17610 ENOG4105NQG DoxX F3L20_17695 ENOG41090E6 transcriptional regulator MERR family F3L20_17710 ENOG4105ETE Transcriptional regulator (LacI family F3L20_17725 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component F3L20_17750 ENOG4105CD3 dihydroorotase F3L20_17790 ENOG4107Z6X Transcriptional regulator F3L20_17860 ENOG4105CHP RNA polymerase F3L20_17865 ENOG4105GRZ Ycii-related protein F3L20_17870 ENOG4107RWR Sodium hydrogen exchanger F3L20_17900 ENOG4105EBM Alpha Beta Hydrolase Fold protein F3L20_17920 ENOG4105EXU Membrane F3L20_17930 ENOG4105D5Q Arginine ornithine antiporter F3L20_17980 ENOG4108UW5 maltose o-acetyltransferase F3L20_17990 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) F3L20_18025 ENOG4105KVH Transcriptional regulator F3L20_18040 ENOG4108YRB methyltransferase F3L20_18060 ENOG4108N5B 2-phosphosulfolactate phosphatase F3L20_18120 ENOG4105F27 Major Facilitator F3L20_18125 ENOG4105D2N Aldolase F3L20_18130 ENOG4105DE4 1-phosphofructokinase F3L20_18135 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) F3L20_18140 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component F3L20_18155 ENOG4105E98 transcriptional regulator DeoR family F3L20_18170 ENOG4105C0R drug resistance transporter emrb qaca subfamily F3L20_18180 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A F3L20_18210 ENOG41086D8 Transcriptional regulator F3L20_18270 ENOG4107TXC Transcriptional regulator F3L20_18275 ENOG4105DR5 peptidase F3L20_18285 ENOG4108QXE glycerophosphoryl diester phosphodiesterase F3L20_18295 ENOG4108KPJ rna polymerase sigma factor F3L20_18305 ENOG4107SCK Monooxygenase F3L20_18320 ENOG4108JGH Tetr family transcriptional regulator F3L20_18360 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_18365 ENOG4105BZU Histidine kinase F3L20_18390 ENOG4105E98 transcriptional regulator DeoR family F3L20_18395 ENOG4106UW1 Major Facilitator superfamily F3L20_18400 ENOG4108KPJ rna polymerase sigma factor F3L20_18440 ENOG4105ETE Transcriptional regulator (LacI family F3L20_18490 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) F3L20_18500 ENOG4105WZW rhodanese family F3L20_18505 ENOG4105VPX protein, conserved in bacteria F3L20_18515 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) F3L20_18530 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 F3L20_18555 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) F3L20_18560 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) F3L20_18565 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) F3L20_18580 ENOG4107QN2 dihydrolipoyl dehydrogenase F3L20_18585 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) F3L20_18590 ENOG41068WN F3L20_18595 ENOG41066UM arsR family transcriptional regulator F3L20_18610 ENOG4105E0A ABC, transporter F3L20_18615 ENOG4105CC5 ABC transporter F3L20_18650 ENOG4108U1V ABC transporter, permease F3L20_18655 ENOG4108U1V ABC transporter, permease F3L20_18660 ENOG4105E0A ABC, transporter F3L20_18685 ENOG4105BZ1 (ABC) transporter F3L20_18690 ENOG4105BZ1 (ABC) transporter F3L20_18705 ENOG4105C9B Cysteine desulfurase F3L20_18715 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) F3L20_18725 ENOG4105NRA 50s ribosomal protein l31 type b F3L20_18730 ENOG4105W0E 50S ribosomal protein L33 F3L20_18735 ENOG4105KDC 50s ribosomal protein l28 F3L20_18740 ENOG41082R9 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) F3L20_18755 ENOG4105H9W Short-chain dehydrogenase reductase Sdr F3L20_18765 ENOG4105EMN RNA polymerase sigma factor F3L20_18785 ENOG4105EE1 crotonyl-CoA reductase F3L20_18800 ENOG4105CEY Amp-dependent synthetase and ligase F3L20_18810 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit F3L20_18820 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit F3L20_18825 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit F3L20_18830 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F3L20_18835 ENOG4105CHR reductase F3L20_18840 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) F3L20_18850 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) F3L20_18870 ENOG4105D0M Protease HtpX homolog F3L20_18905 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) F3L20_18950 ENOG4105H3G oxidoreductase F3L20_18955 ENOG41082YX Transcriptional regulator, arsr family F3L20_18975 ENOG4105D8K carboxyl transferase F3L20_18990 ENOG41064MX Tetr family transcriptional regulator F3L20_19110 ENOG4105CJA serine threonine protein kinase F3L20_19125 ENOG4107RSM transcriptional regulator F3L20_19160 ENOG4108R5S membrane F3L20_19175 ENOG41082JN Transcriptional regulator F3L20_19180 ENOG4105DQ4 alcohol dehydrogenase F3L20_19215 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) F3L20_19280 ENOG4107VXM glycerophosphoryl diester phosphodiesterase F3L20_19310 ENOG4105KJJ Uncharacterized ACR, COG1993 F3L20_19325 ENOG4105CHH sulfate transporter F3L20_19330 ENOG4107RSM transcriptional regulator F3L20_19375 ENOG4105ECQ AraC Family Transcriptional Regulator F3L20_19385 ENOG4105C9U ATP-dependent DNA helicase RecQ F3L20_19415 ENOG4107YPT transcriptional regulator F3L20_19425 ENOG4108ZJ4 polysaccharide deacetylase F3L20_19440 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_19460 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) F3L20_19525 ENOG4105E2R ROK family F3L20_19535 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component F3L20_19545 ENOG4105EX0 alpha-galactosidase F3L20_19560 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) F3L20_19575 ENOG4105U5Y Transcriptional regulator F3L20_19580 ENOG4108VQR secreted hydrolase F3L20_19590 ENOG4105CQB FAD linked oxidase domain protein F3L20_19600 ENOG4105DTQ mandelate racemase muconate lactonizing F3L20_19615 ENOG4108JQ7 (ABC) transporter F3L20_19625 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F3L20_19630 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F3L20_19635 ENOG4105DEF Extracellular solute-binding protein, family 5 F3L20_19645 ENOG4107S1E Beta-lactamase F3L20_19650 ENOG4108R85 Short chain dehydrogenase F3L20_19660 ENOG4107T8T UPF0173 metal-dependent hydrolase F3L20_19690 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein F3L20_19705 ENOG4105CXK mandelate racemase muconate lactonizing F3L20_19710 ENOG4105JXH GntR family transcriptional regulator F3L20_19725 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component F3L20_19730 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component F3L20_19740 ENOG4105EX0 alpha-galactosidase F3L20_19750 ENOG4107TXC Transcriptional regulator F3L20_19760 ENOG4107ZHV Transcriptional regulator F3L20_19765 ENOG4105BZU Histidine kinase F3L20_19770 ENOG4107T5V SNARE associated Golgi F3L20_19815 ENOG4108RPX mosc domain containing protein F3L20_19820 ENOG4105H9W Short-chain dehydrogenase reductase Sdr F3L20_19875 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr F3L20_19880 ENOG4108IND Tetr family transcriptional regulator F3L20_19975 ENOG4105ETE Transcriptional regulator (LacI family F3L20_19990 ENOG4108SIC Transcriptional regulator F3L20_20010 ENOG4105CGD Nad-dependent epimerase dehydratase F3L20_20020 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction F3L20_20055 ENOG4105BZ9 Cytochrome C oxidase, subunit I F3L20_20070 ENOG4105WN5 stage II sporulation protein F3L20_20095 ENOG4107YUH hydrolase F3L20_20125 ENOG4105E8R UPF0173 metal-dependent hydrolase F3L20_20140 ENOG4105EMU Dehydrogenase F3L20_20150 ENOG4108ZJ4 polysaccharide deacetylase F3L20_20185 ENOG4105DRS transport system, permease F3L20_20190 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component F3L20_20200 ENOG4105ETE Transcriptional regulator (LacI family F3L20_20225 ENOG4108638 50S ribosomal protein L36 F3L20_20230 ENOG4105NRA 50s ribosomal protein l31 type b F3L20_20255 ENOG4105CSH Transporter F3L20_20300 ENOG4108FN7 Aldo keto reductase F3L20_20345 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) F3L20_20355 ENOG4107EJG GntR family transcriptional regulator F3L20_20360 ENOG4105C01 Dihydroxy-acid dehydratase F3L20_20370 ENOG4107QK4 glycoside hydrolase, family 3 domain protein F3L20_20380 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component F3L20_20390 ENOG4105ETE Transcriptional regulator (LacI family F3L20_20395 ENOG41062D9 Histidine kinase F3L20_20400 ENOG4105ETX regulatoR F3L20_20415 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) F3L20_20420 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) F3L20_20430 ENOG4105CQM Urea amidohydrolase subunit alpha F3L20_20435 ENOG4108F09 Urease subunit gamma beta F3L20_20460 ENOG41083TI Protein CrcB homolog F3L20_20470 ENOG4105EUB pirin domain protein F3L20_20490 ENOG4105DRS transport system, permease F3L20_20495 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component F3L20_20515 ENOG4105ETE Transcriptional regulator (LacI family F3L20_20520 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator F3L20_20525 ENOG4105C2J ABC transporter F3L20_20530 ENOG4107R9N ABC transporter F3L20_20535 ENOG4105CNN ABC, transporter F3L20_20590 ENOG41080HT Transcriptional regulator, arsr family F3L20_20620 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) F3L20_20625 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin F3L20_20645 ENOG4108VGI doxx family F3L20_20660 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) F3L20_20665 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_20680 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) F3L20_20690 ENOG4107NA1 Endonuclease Exonuclease phosphatase F3L20_20715 ENOG4108KPJ rna polymerase sigma factor F3L20_20725 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) F3L20_20760 ENOG4108KPJ rna polymerase sigma factor F3L20_20770 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate F3L20_20825 ENOG4106A3M Cytochrome p-450 F3L20_20835 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase F3L20_20840 ENOG4105CHR reductase F3L20_20850 ENOG4105DDN Pentapeptide repeat-containing protein F3L20_20895 ENOG4105P3N Membrane F3L20_20925 ENOG4105CBD Diacylglycerol kinase F3L20_20950 ENOG4105CGS Alpha-glucosidase F3L20_20995 ENOG4108JQ1 Dehydrogenase F3L20_21000 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component F3L20_21005 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component F3L20_21065 ENOG4107SGM protein serine threonine phosphatase F3L20_21075 ENOG4105CVN desaturase F3L20_21105 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) F3L20_21110 ENOG4108KEZ Dehydrogenase F3L20_21195 ENOG41089UC methyltransferase, type 11 F3L20_21210 ENOG4105E2A Dehydrogenase F3L20_21215 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic F3L20_21240 ENOG4105DGI Alkaline phosphatase F3L20_21245 ENOG4106T9R serine protease F3L20_21275 ENOG4107E6A Cytochrome p-450 F3L20_21290 ENOG4105CH6 catalase F3L20_21300 ENOG4107RTD sua5 ycio yrdc ywlc family protein F3L20_21320 ENOG4105CV8 reductase F3L20_21325 ENOG4105DQE DNA ligase F3L20_21350 ENOG4105DQE DNA ligase F3L20_21360 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) F3L20_21420 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) F3L20_21425 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) F3L20_21450 ENOG4105BZU Histidine kinase F3L20_21465 ENOG4107MMM Anti-sigma-factor antagonist F3L20_21470 ENOG4105FUA antagonist F3L20_21475 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase F3L20_21490 ENOG4105CEP NADH dehydrogenase F3L20_21535 ENOG4105E8G Major facilitator Superfamily F3L20_21545 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) F3L20_21595 ENOG4105C5X domain protein F3L20_21615 ENOG4105CUX Signal transduction histidine kinase F3L20_21625 ENOG4105K4I Scp-like extracellular F3L20_21635 ENOG4105C7B Threonine dehydratase F3L20_21640 ENOG4107QPV Serine Threonine protein kinase F3L20_21650 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone F3L20_21655 ENOG4105KF0 sporulation and cell division protein, SsgA F3L20_21670 ENOG4107SET aldo keto reductase F3L20_21675 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) F3L20_21695 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) F3L20_21700 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) F3L20_21705 ENOG4105WBV Transcriptional regulator F3L20_21710 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L20_21745 ENOG4105CPC Aldo Keto reductase F3L20_21750 ENOG4108M0I Transcriptional regulator F3L20_21760 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) F3L20_21765 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase F3L20_21870 ENOG4107S1E Beta-lactamase F3L20_21895 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) F3L20_21935 ENOG4107QRI Phosphoketolase F3L20_21945 ENOG4105CK7 Sodium proline symporter F3L20_21960 ENOG4105WZW rhodanese family F3L20_21965 ENOG4105XTG Pfam:DUF156 F3L20_21970 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) F3L20_21985 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L20_21995 ENOG4105CMT Dihydroxyacetone kinase F3L20_22000 ENOG4108UTZ Dihydroxyacetone kinase F3L20_22030 ENOG4108R85 Short chain dehydrogenase F3L20_22040 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F3L20_22060 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) F3L20_22080 ENOG4105I82 acetyl xylan esterase F3L20_22095 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) F3L20_22110 ENOG41073TP transcriptional regulator F3L20_22180 ENOG4105KTE polyketide synthesis cyclase F3L20_22215 ENOG4105CYX Short-chain dehydrogenase reductase Sdr F3L20_22230 ENOG4105CHR reductase F3L20_22240 ENOG4107QN2 dihydrolipoyl dehydrogenase F3L20_22265 ENOG4105C7K acetolactate synthase F3L20_22310 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) F3L20_22340 ENOG4106F1P AAA ATPase, central domain protein F3L20_22350 ENOG4105MVE transcriptional regulator F3L20_22385 ENOG410905P Pyridoxamine 5-phosphate F3L20_22390 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase F3L20_22395 ENOG4105E2R ROK family F3L20_22400 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) F3L20_22405 ENOG4105BZP glycoside hydrolase 15-related F3L20_22425 ENOG4106YYS transcriptional regulatory protein F3L20_22460 ENOG4105CYX Short-chain dehydrogenase reductase Sdr F3L20_22475 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_22480 ENOG4105BZU Histidine kinase F3L20_22500 ENOG4107PP3 Acetylornithine deacetylase F3L20_22530 ENOG41060NJ transcriptional regulator F3L20_22540 ENOG4105VMP Transcriptional regulator F3L20_22555 ENOG4105C10 Electron transfer flavoprotein F3L20_22575 ENOG4105E9Q Acyl-transferase F3L20_22610 ENOG4108QXE glycerophosphoryl diester phosphodiesterase F3L20_22645 ENOG410841Q phosphoesterase PA-phosphatase related protein F3L20_22650 ENOG41082JN Transcriptional regulator F3L20_22680 ENOG4105YVS arsR family transcriptional regulator F3L20_22685 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F3L20_22690 ENOG4108E16 pectate lyase F3L20_22700 ENOG4105CSU acyl-Coa dehydrogenase F3L20_22710 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) F3L20_22735 ENOG4107VXZ Hydrolase F3L20_22765 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) F3L20_22790 ENOG4105H3G oxidoreductase F3L20_22800 ENOG4105BZ1 (ABC) transporter F3L20_22815 ENOG4105BZ1 (ABC) transporter F3L20_22825 ENOG4105NRA 50s ribosomal protein l31 type b F3L20_22840 ENOG4105C29 acyl-CoA thioesterase F3L20_22850 ENOG4105GWZ Roadblock lc7 family protein F3L20_22880 ENOG4105BZU Histidine kinase F3L20_22930 ENOG4105D2B acyl-CoA dehydrogenase F3L20_22935 ENOG4105D2B acyl-CoA dehydrogenase F3L20_22940 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein F3L20_22945 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR F3L20_22955 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) F3L20_22965 ENOG4105C26 Dehydrogenase F3L20_22975 ENOG4105C1G acyl-Coa dehydrogenase F3L20_22985 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) F3L20_22990 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) F3L20_22995 ENOG4105F1K Glutamine amidotransferase F3L20_23000 ENOG4105CTQ phosphohexokinase F3L20_23015 ENOG4108HRK Histidine kinase F3L20_23020 ENOG4107QN1 sodium solute F3L20_23030 ENOG4108NEV two component transcriptional regulator, LytTR family F3L20_23040 ENOG4105CIK Amidinotransferase F3L20_23045 ENOG4105C8Y Acetylornithine aminotransferase F3L20_23060 ENOG4105CPQ Dehydrogenase F3L20_23100 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F3L20_23110 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) F3L20_23115 ENOG4108RFG Tetr family transcriptional regulator F3L20_23125 ENOG4105VG1 fes assembly suf system protein F3L20_23130 ENOG4108UNV SUF system FeS assembly protein, NifU family F3L20_23135 ENOG4105C9B Cysteine desulfurase F3L20_23140 ENOG4105C3K feS assembly ATPase SufC F3L20_23150 ENOG4105JRK feS assembly protein SufD F3L20_23165 ENOG4105CJ1 ABC, transporter F3L20_23175 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) F3L20_23195 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) F3L20_23210 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) F3L20_23225 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) F3L20_23230 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component F3L20_23235 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component F3L20_23245 ENOG4105CG3 alpha amylase, catalytic region F3L20_23260 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) F3L20_23285 ENOG4105CP7 Triose-phosphate isomerase F3L20_23290 ENOG4105BZA Phosphoglycerate kinase F3L20_23295 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase F3L20_23305 ENOG4105CIE May be required for sporulation (By similarity) F3L20_23310 ENOG4105CHW UPF0052 protein F3L20_23315 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) F3L20_23320 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) F3L20_23335 ENOG4105ETE Transcriptional regulator (LacI family F3L20_23345 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) F3L20_23355 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) F3L20_23360 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) F3L20_23385 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) F3L20_23390 ENOG4105BZU Histidine kinase F3L20_23395 ENOG4108QXE glycerophosphoryl diester phosphodiesterase F3L20_23400 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) F3L20_23410 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) F3L20_23420 ENOG4105D7N magnesium and cobalt transport protein CorA F3L20_23480 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) F3L20_23495 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) F3L20_23500 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) F3L20_23510 ENOG4105E2A Dehydrogenase F3L20_23525 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) F3L20_23530 ENOG4108D32 Methyltransferase F3L20_23545 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) F3L20_23555 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) F3L20_23565 ENOG4105CQ7 ATP-dependent helicase F3L20_23595 ENOG4105KA0 thioesterase Superfamily protein F3L20_23615 ENOG4105C32 Amino acid ABC transporter (Permease) F3L20_23620 ENOG4105CF8 branched-chain amino acid ABC transporter, permease F3L20_23625 ENOG4105C0Z ABC transporter F3L20_23630 ENOG4108IV0 ABC, transporter F3L20_23655 ENOG4105CGH 5'-nucleotidase F3L20_23665 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L20_23670 ENOG4105EHE chorismate mutase- prephenate dehydrogenase F3L20_23695 ENOG4105CBC glutamate synthase F3L20_23705 ENOG41065RQ ADP-ribosylation crystallin J1 F3L20_23725 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F F3L20_23730 ENOG4105CI0 Citrate lyase F3L20_23735 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) F3L20_23745 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) F3L20_23750 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) F3L20_23760 ENOG4105DK0 Indole-3-glycerol phosphate synthase F3L20_23785 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase F3L20_23795 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase F3L20_23800 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) F3L20_23805 ENOG4108176 endoribonuclease L-psp F3L20_23810 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase F3L20_23815 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) F3L20_23820 ENOG4105ECC imidazole-glycerol-phosphate dehydratase F3L20_23825 ENOG4105CIH Imidazole acetol-phosphate transaminase F3L20_23830 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) F3L20_23850 ENOG4108Z66 YbaK ebsC protein F3L20_23880 ENOG4105C0B DNA polymerase III (alpha subunit) F3L20_23935 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) F3L20_23940 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters F3L20_23945 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) F3L20_23950 ENOG4107VQS DivIVA family F3L20_23960 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) F3L20_23965 ENOG4105DFA alanine racemase domain protein F3L20_23970 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase F3L20_23975 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) F3L20_23980 ENOG4105ME9 cell division protein FtsQ F3L20_23985 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) F3L20_23995 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) F3L20_24000 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) F3L20_24010 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) F3L20_24015 ENOG4105CJN penicillin-binding protein F3L20_24025 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) F3L20_24035 ENOG4105C7R Atpase associated with various cellular activities aaa_3 F3L20_24055 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) F3L20_24065 ENOG4105C2J ABC transporter F3L20_24075 ENOG4107Z3H Transcriptional regulator, TetR family F3L20_24080 ENOG4105EWK phytoene F3L20_24120 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) F3L20_24130 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) F3L20_24140 ENOG4108UQY Iron-storage protein F3L20_24150 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase F3L20_24170 ENOG4105CTQ phosphohexokinase F3L20_24180 ENOG4105ENE Histidine kinase F3L20_24205 ENOG4105DKQ ROK family F3L20_24215 ENOG4105D0U Arsenite-activated ATPase (ArsA) F3L20_24280 ENOG4105C9B Cysteine desulfurase F3L20_24285 ENOG4108I0Q anthranilate phosphoribosyltransferase F3L20_24290 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) F3L20_24295 ENOG4107EUI c reductase, iron-sulfur F3L20_24300 ENOG4107UDY cytochrome C F3L20_24305 ENOG4105CCU oxidase (Subunit III) F3L20_24320 ENOG4105MCD Part of cytochrome c oxidase, its function is F3L20_24325 ENOG4105BZ9 Cytochrome C oxidase, subunit I F3L20_24330 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) F3L20_24335 ENOG4105C3J Cysteine desulfurase F3L20_24365 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) F3L20_24375 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_24380 ENOG4105BZU Histidine kinase F3L20_24410 ENOG4108YZT Adenosylcobinamide kinase F3L20_24420 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) F3L20_24430 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) F3L20_24445 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) F3L20_24465 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) F3L20_24510 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) F3L20_24515 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) F3L20_24535 ENOG4105C5F glutamine synthetase F3L20_24540 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F3L20_24590 ENOG4105E4C Lytic transglycosylase catalytic F3L20_24665 ENOG4108222 arsenate reductase F3L20_24670 ENOG4106SPC secreted protein F3L20_24675 ENOG4107R5B glutamine synthetase F3L20_24680 ENOG4107NHD transcriptional regulator F3L20_24695 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_24715 ENOG41060BG Tetr family transcriptional regulator F3L20_24740 ENOG4105CG3 alpha amylase, catalytic region F3L20_24745 ENOG4105EG2 ABC transporter, permease F3L20_24750 ENOG4105D56 permease protein F3L20_24755 ENOG4107FKK extracellular solute-binding protein family 1 F3L20_24760 ENOG4105ETE Transcriptional regulator (LacI family F3L20_24770 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) F3L20_24800 ENOG4108J20 pectate lyase F3L20_24810 ENOG4105C5F glutamine synthetase F3L20_24815 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F3L20_24820 ENOG41081JD Transcriptional regulator F3L20_24835 ENOG4105C4K Nad synthetase F3L20_24875 ENOG4107XZ0 Peptidase M50 F3L20_24930 ENOG4106A0S F3L20_24940 ENOG4107T6V glycerophosphoryl diester phosphodiesterase F3L20_24960 ENOG4107S1E Beta-lactamase F3L20_24965 ENOG4105C2C drug resistance transporter, Bcr CflA F3L20_24975 ENOG4105DGI Alkaline phosphatase F3L20_24980 ENOG41061TZ Short-chain dehydrogenase reductase Sdr F3L20_24985 ENOG4105CPC Aldo Keto reductase F3L20_25035 ENOG4105E7U AraC family transcriptional regulator F3L20_25050 ENOG4107XFJ UPF0246 protein F3L20_25055 ENOG4108UHU Aldolase F3L20_25060 ENOG4105CVJ phosphoglycerate mutase F3L20_25070 ENOG4105EGD dinuclear metal center protein, YbgI family F3L20_25085 ENOG4105BZU Histidine kinase F3L20_25110 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase F3L20_25130 ENOG4107QVI Methyltransferase, type 11 F3L20_25135 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) F3L20_25140 ENOG4108SGK Tetr family transcriptional regulator F3L20_25160 ENOG4108JJB ABC transporter F3L20_25205 ENOG4105CSH Transporter F3L20_25315 ENOG4107T5V SNARE associated Golgi F3L20_25325 ENOG4105DAX Pfam:DUF2983 F3L20_25375 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) F3L20_25405 ENOG4105CPC Aldo Keto reductase F3L20_25410 ENOG4105VUF Transcriptional regulator F3L20_25440 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin F3L20_25480 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) F3L20_25485 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) F3L20_25505 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) F3L20_25510 ENOG4105NGS secreted protein F3L20_25515 ENOG4105N14 lysine exporter protein LysE YggA F3L20_25525 ENOG4105C57 major facilitator superfamily F3L20_25535 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein F3L20_25550 ENOG4105CXK mandelate racemase muconate lactonizing F3L20_25565 ENOG4105DFW ABC transporter F3L20_25575 ENOG4108HWW ABC transporter F3L20_25580 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) F3L20_25585 ENOG4105CIH Imidazole acetol-phosphate transaminase F3L20_25710 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein F3L20_25715 ENOG4105J4Q Transcriptional regulator F3L20_25785 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L20_25790 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) F3L20_25800 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein F3L20_25810 ENOG4108UB4 uncharacterized protein ygjQ F3L20_25815 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) F3L20_25850 ENOG4107QZF nitrite reductase NADPH large subunit F3L20_25880 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) F3L20_25915 ENOG4105CPC Aldo Keto reductase F3L20_25920 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) F3L20_25925 ENOG4105DSE periplasmic solute binding protein F3L20_25930 ENOG4105FDK ABC transporter F3L20_25935 ENOG4105FAV ABC, transporter F3L20_25945 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) F3L20_25950 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) F3L20_25990 ENOG4106JDR secreted F3L20_26005 ENOG4105BZU Histidine kinase F3L20_26010 ENOG4105EYF MMPL domain protein F3L20_26055 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) F3L20_26060 ENOG4105D4Y metalloprotease F3L20_26075 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) F3L20_26085 ENOG4105MSB protein, conserved in bacteria F3L20_26095 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) F3L20_26105 ENOG4107UEK pfkb domain protein F3L20_26110 ENOG4105EQX glucarate dehydratase F3L20_26120 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) F3L20_26125 ENOG4107YU2 histidine triad (hIT) protein F3L20_26130 ENOG4107RE3 peptidase, S41 F3L20_26145 ENOG4107QWG 2-Nitropropane dioxygenase F3L20_26150 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) F3L20_26155 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) F3L20_26180 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein F3L20_26190 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) F3L20_26200 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) F3L20_26225 ENOG4105KQC Competence protein F3L20_26230 ENOG4105EPR degv family F3L20_26240 ENOG4105C8T Leucyl-tRNA synthetase F3L20_26255 ENOG4107QIZ NADH dehydrogenase F3L20_26280 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) F3L20_26285 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) F3L20_26295 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) F3L20_26300 ENOG4105D0M Protease HtpX homolog F3L20_26315 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) F3L20_26325 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) F3L20_26335 ENOG4105C39 capsular polysaccharide phosphotransferase F3L20_26350 ENOG4105EXC Acyl-transferase F3L20_26355 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control F3L20_26360 ENOG4105K46 50S ribosomal protein l27 F3L20_26365 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) F3L20_26375 ENOG4105C03 ribonuclease F3L20_26405 ENOG4105CNI cell division protein FtsW F3L20_26410 ENOG4105CJN penicillin-binding protein F3L20_26425 ENOG4105DFF Rod shape-determining protein mreb F3L20_26430 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) F3L20_26440 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase F3L20_26450 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) F3L20_26465 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) F3L20_26470 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) F3L20_26475 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) F3L20_26480 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation F3L20_26500 ENOG4108TGC Acyltransferase F3L20_26530 ENOG4105C85 amino acid F3L20_26545 ENOG4105GVF (ABC) transporter F3L20_26555 ENOG4105E2Y ABC, transporter F3L20_26570 ENOG4105C85 amino acid F3L20_26580 ENOG4105MC2 DSBA oxidoreductase F3L20_26640 ENOG4105U5Y Transcriptional regulator F3L20_26655 ENOG4108ZT1 Transcriptional regulator F3L20_26670 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_26690 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 F3L20_26700 ENOG4105D8X mechanosensitive ion channel F3L20_26710 ENOG4105BZ7 extracellular solute-binding protein family 1 F3L20_26720 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component F3L20_26725 ENOG4105F8D glycoside hydrolase family 4 F3L20_26740 ENOG4107UBR Extracellular solute-binding protein family 3 F3L20_26770 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) F3L20_26790 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) F3L20_26825 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) F3L20_26900 ENOG4105D3Q Sugar transferase F3L20_26910 ENOG4105CJR Integral membrane protein (MviN F3L20_26920 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) F3L20_26940 ENOG4105C3M thioredoxin reductase F3L20_26945 ENOG4105S2J secreted protein F3L20_26955 ENOG4105CJ1 ABC, transporter F3L20_26960 ENOG4105C26 Dehydrogenase F3L20_27005 ENOG4105CIR epoxide hydrolase F3L20_27040 ENOG4105ETE Transcriptional regulator (LacI family F3L20_27045 ENOG4105C2J ABC transporter F3L20_27050 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator F3L20_27055 ENOG4108RVA ribokinase F3L20_27060 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) F3L20_27080 ENOG4105ETE Transcriptional regulator (LacI family F3L20_27110 ENOG4108594 Permease of the drug metabolite transporter F3L20_27120 ENOG4105D17 glycoside hydrolase, family 3 domain protein F3L20_27145 ENOG4108K8S endonuclease I F3L20_27160 ENOG4105C7K acetolactate synthase F3L20_27170 ENOG4105CK7 Sodium proline symporter F3L20_27190 ENOG4108XFF F3L20_27200 ENOG4105C29 acyl-CoA thioesterase F3L20_27215 ENOG4107QX3 carboxylase F3L20_27225 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase F3L20_27230 ENOG4105C1G acyl-Coa dehydrogenase F3L20_27255 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) F3L20_27265 ENOG4105DUU IucA IucC family protein F3L20_27280 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) F3L20_27295 ENOG4105ECQ AraC Family Transcriptional Regulator F3L20_27300 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) F3L20_27310 ENOG4105ETE Transcriptional regulator (LacI family F3L20_27325 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component F3L20_27335 ENOG4108NNZ chitinase F3L20_27340 ENOG4105BZU Histidine kinase F3L20_27380 ENOG4108ZM9 phosphoglycerate mutase F3L20_27405 ENOG4105DEN Luciferase family F3L20_27410 ENOG4105BZU Histidine kinase F3L20_27480 ENOG4108M1A Chitin-binding protein F3L20_27510 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) F3L20_27540 ENOG4105D9R oxidoreductase F3L20_27545 ENOG41090KN UPF0303 protein F3L20_27560 ENOG4105ERH Fumarylacetoacetate hydrolase F3L20_27565 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins F3L20_27665 ENOG4108RFG Tetr family transcriptional regulator F3L20_27670 ENOG4108UW5 maltose o-acetyltransferase F3L20_27690 ENOG4107QNK )-transporter F3L20_27695 ENOG4106BRA Membrane F3L20_27715 ENOG4108IUW ABC transporter F3L20_27730 ENOG4105BZ4 penicillin-binding protein F3L20_27770 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) F3L20_27780 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) F3L20_27785 ENOG4105CI1 PTS System F3L20_27795 ENOG4105CI1 PTS System F3L20_27800 ENOG4108RQ5 Beta-lactamase domain-containing protein F3L20_27825 ENOG4105C85 amino acid F3L20_27835 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) F3L20_27845 ENOG4108RWI nicotinamidase F3L20_27855 ENOG4107G87 m6 family metalloprotease domain protein F3L20_27875 ENOG4105CQB FAD linked oxidase domain protein F3L20_27885 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase F3L20_27895 ENOG4105E90 ABC transporter F3L20_27900 ENOG4108IJ8 ABC transporter F3L20_27905 ENOG4105E90 ABC transporter F3L20_27910 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system F3L20_27930 ENOG41086VY Fic/DOC family F3L20_27940 ENOG4105C0R drug resistance transporter emrb qaca subfamily F3L20_27960 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding F3L20_27975 ENOG4105E2D ec 3.2.1.52 F3L20_28000 ENOG4108UJU UPF0301 protein F3L20_28005 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) F3L20_28010 ENOG4108426 dNA-binding protein F3L20_28020 ENOG4105EEM helicase F3L20_28050 ENOG4105DQQ Major facilitator superfamily MFS_1 F3L20_28065 ENOG4108ZJ4 polysaccharide deacetylase F3L20_28105 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) F3L20_28110 ENOG4105CN1 protease F3L20_28120 ENOG4105CAK Cell division ATP-binding protein ftsE F3L20_28135 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) F3L20_28140 ENOG4108QVN serine threonine protein kinase F3L20_28145 ENOG4108UGD Serine Threonine protein kinase F3L20_28165 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component F3L20_28170 ENOG4105K64 Glycosyl transferase, family 2 F3L20_28175 ENOG4107SJB teichoic acid biosynthesis F3L20_28180 ENOG4105K64 Glycosyl transferase, family 2 F3L20_28195 ENOG4108ZHJ Organic hydroperoxide resistance protein F3L20_28200 ENOG4105K56 Transcriptional regulator F3L20_28220 ENOG4105EY8 ABC transporter F3L20_28225 ENOG4107SJB teichoic acid biosynthesis F3L20_28230 ENOG4105K64 Glycosyl transferase, family 2 F3L20_28240 ENOG4105C7I Dehydrogenase F3L20_28260 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving F3L20_28270 ENOG4105T0Z Conserved Protein F3L20_28275 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_28280 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea F3L20_28295 ENOG4105G3P Lipoprotein lpqB F3L20_28300 ENOG4105BZU Histidine kinase F3L20_28305 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L20_28310 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) F3L20_28325 ENOG4108WQ6 secreted protein F3L20_28330 ENOG4105C7R Atpase associated with various cellular activities aaa_3 F3L20_28375 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) F3L20_28390 ENOG4105EIP mannose-6-phosphate isomerase F3L20_28400 ENOG4105W49 UPF0434 protein F3L20_28405 ENOG4107QKV phosphomannomutase F3L20_28410 ENOG4105DAA L-lactate F3L20_28430 ENOG4107RGC Glycosyl transferase, family 2 F3L20_28435 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) F3L20_28445 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase F3L20_28450 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) F3L20_28460 ENOG4107V9E glucose-1-phosphate thymidylyltransferase F3L20_28475 ENOG4108KGH TRANSCRIPTIONal F3L20_28480 ENOG4108KGH TRANSCRIPTIONal F3L20_28485 ENOG4107TB5 TRANSCRIPTIONal F3L20_28500 ENOG4108KGH TRANSCRIPTIONal F3L20_28505 ENOG4108S4H thioesterase Superfamily protein F3L20_28510 ENOG4108KGH TRANSCRIPTIONal F3L20_28520 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) F3L20_28535 ENOG4105C6Y Udp-glucose 6-dehydrogenase F3L20_28565 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) F3L20_28580 ENOG41065SU Two-component system sensor kinase F3L20_28585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L20_28590 ENOG4105DUX Transporter F3L20_28600 ENOG41082AN stage II sporulation protein F3L20_28605 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L20_28610 ENOG4105CI2 imidazolone-5-propionate hydrolase F3L20_28625 ENOG4105CGP Urocanate hydratase F3L20_28645 ENOG4108KGH TRANSCRIPTIONal F3L20_28665 ENOG4105CHU acetyl-coa acetyltransferase F3L20_28705 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) F3L20_28710 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) F3L20_28715 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase F3L20_28720 ENOG4105CEP NADH dehydrogenase F3L20_28740 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) F3L20_28765 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) F3L20_28810 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) F3L20_28815 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) F3L20_28825 ENOG4107QN1 sodium solute F3L20_28870 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) F3L20_28875 ENOG4105C5T Phosphoribosyl pyrophosphate synthase F3L20_28880 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) F3L20_28885 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) F3L20_28895 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) F3L20_28905 ENOG41067SE Tetr family transcriptional regulator F3L20_28915 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) F3L20_28920 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes F3L20_28925 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_28940 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) F3L20_28980 ENOG4105C5H ABC transporter F3L20_28985 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) F3L20_28990 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) F3L20_29000 ENOG4105F8V Hydrolase, tatD family F3L20_29035 ENOG4105G01 cobalamin (vitamin B12) biosynthesis CbiM protein F3L20_29045 ENOG4108JJB ABC transporter F3L20_29070 ENOG4105EYF MMPL domain protein F3L20_29090 ENOG4105CHR reductase F3L20_29095 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) F3L20_29100 ENOG4105F95 Monooxygenase F3L20_29110 ENOG4105CGK Exodeoxyribonuclease III F3L20_29140 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) F3L20_29145 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) F3L20_29160 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase F3L20_29195 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) F3L20_29220 ENOG4105DM4 PTS System F3L20_29225 ENOG4105DE4 1-phosphofructokinase F3L20_29230 ENOG4105E98 transcriptional regulator DeoR family F3L20_29260 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b F3L20_29300 ENOG4105FDP GntR family transcriptional regulator F3L20_29310 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F3L20_29370 ENOG4108V06 Glutathione peroxidase F3L20_29395 ENOG4105DZ1 carboxypeptidase F3L20_29425 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) F3L20_29475 ENOG4108762 serine threonine protein kinase F3L20_29485 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) F3L20_29495 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) F3L20_29505 ENOG4105H3G oxidoreductase F3L20_29510 ENOG4105DCM major facilitator superfamily F3L20_29535 ENOG4105WN5 stage II sporulation protein F3L20_29595 ENOG4108XEP Alpha Beta Hydrolase Fold protein F3L20_29605 ENOG4108SU4 UPF0309 protein F3L20_29625 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) F3L20_29640 ENOG4105CEY Amp-dependent synthetase and ligase F3L20_29655 ENOG4107QX3 carboxylase F3L20_29670 ENOG4107AQZ Membrane F3L20_29690 ENOG4105CQB FAD linked oxidase domain protein F3L20_29730 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) F3L20_29760 ENOG4105CPC Aldo Keto reductase F3L20_29790 ENOG4105C7N Xanthine uracil vitamin C permease F3L20_29800 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic F3L20_29805 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) F3L20_29820 ENOG4105DR5 peptidase F3L20_29850 ENOG4108N0W Major Facilitator superfamily F3L20_29860 ENOG4108UIH futalosine nucleosidase F3L20_29865 ENOG4105E63 Pfam:DUF178 F3L20_29870 ENOG4105VEQ Cold shock protein F3L20_29895 ENOG4105CFI type iii restriction protein res subunit F3L20_29925 ENOG4107S5I aldo keto reductase F3L20_29935 ENOG4105EEM helicase F3L20_29940 ENOG4106N3A copper homeostasis protein cutc F3L20_29955 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid F3L20_29980 ENOG4105QEK Transcriptional regulator F3L20_29985 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate F3L20_30005 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) F3L20_30010 ENOG4105VEQ Cold shock protein F3L20_30025 ENOG4105C3Q Glycosyl transferase, family 2 F3L20_30055 ENOG4105CE4 GlcNAc 6-P deacetylase F3L20_30070 ENOG4105BZU Histidine kinase F3L20_30085 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) F3L20_30140 ENOG4105D29 Helix-turn-helix type 11 domain protein F3L20_30145 ENOG4108IJ9 (ABC) transporter F3L20_30155 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) F3L20_30165 ENOG4105C2N RNA methyltransferase TrmH family group 3 F3L20_30170 ENOG4105C8N cysteinyl-tRNA synthetase F3L20_30175 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) F3L20_30180 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) F3L20_30190 ENOG4108VJ1 Transcriptional regulator (CarD family F3L20_30210 ENOG4105BZU Histidine kinase F3L20_30225 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) F3L20_30250 ENOG4105ECQ AraC Family Transcriptional Regulator F3L20_30265 ENOG4108YZJ Pfam:DUF2596 F3L20_30270 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) F3L20_30290 ENOG4105TT9 Protein of unknown function (DUF2516) F3L20_30325 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component F3L20_30340 ENOG41073TP transcriptional regulator F3L20_30350 ENOG41073TP transcriptional regulator F3L20_30365 ENOG4105FDP GntR family transcriptional regulator F3L20_30385 ENOG4105HHS UPF0256 protein F3L20_30395 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) F3L20_30400 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) F3L20_30405 ENOG41090R7 Ferric uptake F3L20_30410 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands F3L20_30430 ENOG4105PKJ carbohydrate binding F3L20_30435 ENOG4105KHC sulfurtransferase F3L20_30460 ENOG4107NHD transcriptional regulator F3L20_30465 ENOG4105ETE Transcriptional regulator (LacI family F3L20_30470 ENOG4105C0H protease F3L20_30475 ENOG4105ETX regulatoR F3L20_30490 ENOG4105CGH 5'-nucleotidase F3L20_30495 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) F3L20_30510 ENOG4105CJ1 ABC, transporter F3L20_30530 ENOG4105CZV ABC transporter F3L20_30540 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) F3L20_30575 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) F3L20_30580 ENOG4105CJ3 phosphate transporter F3L20_30590 ENOG4105VPX protein, conserved in bacteria F3L20_30605 ENOG4105DNP FAD linked oxidase domain protein F3L20_30610 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase F3L20_30615 ENOG4105E4C Lytic transglycosylase catalytic F3L20_30720 ENOG4105D5U fad dependent oxidoreductase F3L20_30725 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) F3L20_30750 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_30755 ENOG4105BZU Histidine kinase F3L20_30770 ENOG4105C1J atp-dependent rna helicase F3L20_30805 ENOG4105CQ7 ATP-dependent helicase F3L20_30825 ENOG4108TAC F3L20_30830 ENOG4107RDP Dehydrogenase F3L20_30840 ENOG4105CXB phosphoribosylaminoimidazole synthetase F3L20_30860 ENOG4108K5P (LipO)protein F3L20_30870 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii F3L20_30875 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I F3L20_30880 ENOG410839H phosphoribosylformylglycinamidine synthase F3L20_30910 ENOG4105BZU Histidine kinase F3L20_30925 ENOG4105C8V SAICAR synthetase F3L20_30940 ENOG4105C12 Phosphoribosylglycinamide synthetase F3L20_30960 ENOG4105C4R Atp-dependent dna helicase F3L20_30975 ENOG4105CHR reductase F3L20_31015 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) F3L20_31030 ENOG4108Z6B deaminase F3L20_31040 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein F3L20_31045 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L20_31050 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L20_31060 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes F3L20_31070 ENOG4108YYC ycei family F3L20_31085 ENOG410905P Pyridoxamine 5-phosphate F3L20_31095 ENOG4105C57 major facilitator superfamily F3L20_31100 ENOG4105EDW glycosyl transferase, family 39 F3L20_31110 ENOG4105BZU Histidine kinase F3L20_31115 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L20_31145 ENOG4105EYW Ion transport protein F3L20_31150 ENOG4105DNP FAD linked oxidase domain protein F3L20_31175 ENOG4108UXN response regulator F3L20_31180 ENOG4105CEY Amp-dependent synthetase and ligase F3L20_31185 ENOG4105NAF rna polymerase sigma factor F3L20_31230 ENOG4105C0H protease F3L20_31250 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving F3L20_31270 ENOG4107T6F Xaa-Pro aminopeptidase F3L20_31305 ENOG4105DBE peroxidase F3L20_31315 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) F3L20_31320 ENOG410667J hydrolase F3L20_31345 ENOG4105DA5 (ABC) transporter F3L20_31355 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) F3L20_31370 ENOG4108KP7 hydrolase F3L20_31375 ENOG41061JJ Peptidase family M23 F3L20_31380 ENOG4108JJ9 ABC, transporter F3L20_31385 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F3L20_31390 ENOG4105C4M (Ubiquinol oxidase) subunit I F3L20_31395 ENOG4105CIH Imidazole acetol-phosphate transaminase F3L20_31400 ENOG4107P2S Transcriptional regulator F3L20_31405 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) F3L20_31420 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) F3L20_31445 ENOG4106048 Cupin 2, conserved barrel domain protein F3L20_31450 ENOG41082T9 Membrane F3L20_31455 ENOG4105KJF protein tyrosine phosphatase F3L20_31460 ENOG4105C28 cystathionine F3L20_31485 ENOG4105F27 Major Facilitator F3L20_31490 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) F3L20_31510 ENOG4105CDU Replicative dna helicase F3L20_31520 ENOG4105K9Q Binds to the 23S rRNA (By similarity) F3L20_31525 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) F3L20_31530 ENOG4107YH6 single-stranded DNA-binding protein F3L20_31535 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) F3L20_31560 ENOG4105BZ4 penicillin-binding protein F3L20_31570 ENOG4105CZA synthase F3L20_31585 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate F3L20_31615 ENOG4105C3M thioredoxin reductase F3L20_31620 ENOG4105K63 Thioredoxin F3L20_31635 ENOG4107QJE Chromosome Partitioning Protein F3L20_31640 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) F3L20_31650 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins F3L20_31655 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) F3L20_31660 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) F3L20_31665 ENOG41084CH 50S ribosomal protein l34 F3L20_31705 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) F3L20_31730 ENOG4105I6B RNA polymerase F3L20_31760 ENOG41060BG Tetr family transcriptional regulator F3L20_31765 ENOG4107YPT transcriptional regulator F3L20_31770 ENOG4105CHR reductase F3L20_31785 ENOG4105CS1 NAD(P)H quinone oxidoreductase F3L20_31795 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone F3L20_31800 ENOG4108UZX fmn reductase F3L20_31810 ENOG4105M4P Tetr family transcriptional regulator F3L20_31815 ENOG4105E39 Enoyl-CoA hydratase F3L20_31850 ENOG4107QN2 dihydrolipoyl dehydrogenase F3L20_31855 ENOG4105CBP Major Facilitator F3L20_31860 ENOG4108WUH Transcriptional regulator, TetR family F3L20_31875 ENOG4107QJE Chromosome Partitioning Protein F3L20_31925 ENOG4105CS1 NAD(P)H quinone oxidoreductase F3L20_31955 ENOG4106NZI LysR family Transcriptional regulator F3L20_31980 ENOG4105CIR epoxide hydrolase F3L20_31985 ENOG4105CYX Short-chain dehydrogenase reductase Sdr F3L20_31990 ENOG4105MC2 DSBA oxidoreductase F3L20_32005 ENOG4105CEP NADH dehydrogenase F3L20_32020 ENOG4105KF0 sporulation and cell division protein, SsgA F3L20_32045 ENOG4105EQ0 Major Facilitator superfamily F3L20_32070 ENOG4105K56 Transcriptional regulator F3L20_32080 ENOG4105E1F short-chain dehydrogenase reductase F3L20_32085 ENOG4105CHR reductase F3L20_32100 ENOG41061TZ Short-chain dehydrogenase reductase Sdr F3L20_32150 ENOG4108ZHJ Organic hydroperoxide resistance protein F3L20_32180 ENOG4105NDK ethanolamine utilization protein F3L20_32230 ENOG41061TZ Short-chain dehydrogenase reductase Sdr F3L20_32245 ENOG4105EBM Alpha Beta Hydrolase Fold protein F3L20_32300 ENOG4108MP6 LysR family Transcriptional regulator F3L20_32315 ENOG4105CHR reductase F3L20_32325 ENOG4105EMN RNA polymerase sigma factor F3L20_32410 ENOG4107SET aldo keto reductase F3L20_32420 ENOG4105ETE Transcriptional regulator (LacI family F3L20_32425 ENOG4105DKQ ROK family F3L20_32440 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component F3L20_32445 ENOG4105I1K ABC transporter F3L20_32560 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) F3L20_32565 ENOG4105EUB pirin domain protein F3L20_32575 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr F3L20_32620 ENOG4106UDK Cellulose-binding, family II F3L20_32660 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F3L20_32670 ENOG4107QN2 dihydrolipoyl dehydrogenase F3L20_32695 ENOG4105WH1 Two component transcriptional regulator luxr family F3L20_32755 ENOG4106IBS oxygenase F3L20_32785 ENOG4105MIR Phenylalanine 4-monooxygenase F3L20_32955 ENOG4105BZN citrate synthase F3L20_32960 ENOG4105MC2 DSBA oxidoreductase F3L20_32980 ENOG4105CHR reductase F3L20_32985 ENOG4105EQK -acetyltransferase F3L20_33030 ENOG4105ECQ AraC Family Transcriptional Regulator F3L20_33035 ENOG4108X0B nad(p)h dehydrogenase (quinone) F3L20_33120 ENOG4105CZV ABC transporter F3L20_33125 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family F3L20_33140 ENOG4105MC2 DSBA oxidoreductase F3L20_33160 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F3L20_33165 ENOG4107TTQ Alpha beta hydrolase fold F3L20_33220 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F3L20_33250 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F3L20_33300 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) F3L20_33315 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) F3L20_33340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L20_33345 ENOG4105BZU Histidine kinase F3L20_33360 ENOG4105ES4 Nitrilase F3L20_33365 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) F3L20_33370 ENOG4105C6F GntR Family Transcriptional Regulator F3L20_33375 ENOG4105EQK -acetyltransferase F3L20_33450 ENOG410836F Transposase F3L20_33525 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) F3L20_33555 ENOG4105CHR reductase F3L20_33560 ENOG4105E1F short-chain dehydrogenase reductase F3L20_33690 ENOG4108C33 Resolvase F3L20_33700 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)