locus-tag	class	description
GFS03_00055	ENOG4108IEG	Formate dehydrogenase Alpha subunit
GFS03_00065	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
GFS03_00080	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
GFS03_00085	ENOG4105C10	Electron transfer flavoprotein
GFS03_00090	ENOG4105DQU	oxidoreductase, subunit beta
GFS03_00095	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
GFS03_00125	ENOG4105CEY	Amp-dependent synthetase and ligase
GFS03_00145	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
GFS03_00165	ENOG4105CPQ	Dehydrogenase
GFS03_00190	ENOG4105D64	Mechanosensitive ion channel
GFS03_00195	ENOG4107ZTW	SNARE associated Golgi
GFS03_00200	ENOG4105CPP	Dehydrogenase, E1 component
GFS03_00205	ENOG4107RUY	(E1 component), alpha subunit
GFS03_00210	ENOG4105CV8	reductase
GFS03_00215	ENOG4107YZX	Universal stress protein
GFS03_00235	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
GFS03_00240	ENOG4105C7K	acetolactate synthase
GFS03_00255	ENOG4105DZC	cytosine deaminase
GFS03_00280	ENOG4105C3M	thioredoxin reductase
GFS03_00290	ENOG4105BZJ	Electron transfer flavoprotein
GFS03_00300	ENOG4105C1G	acyl-Coa dehydrogenase
GFS03_00315	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
GFS03_00320	ENOG4105EJ5	oxidoreductase gamma subunit
GFS03_00325	ENOG4105WGB	oxidoreductase, delta subunit
GFS03_00330	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
GFS03_00335	ENOG4105DDK	oxidoreductase, beta subunit
GFS03_00340	ENOG4107STW	synthase
GFS03_00345	ENOG4105BZP	glycoside hydrolase 15-related
GFS03_00405	ENOG4105BZP	glycoside hydrolase 15-related
GFS03_00415	ENOG41080XP	Cbs domain
GFS03_00425	ENOG4107QSE	Dipeptidase
GFS03_00455	ENOG4105CYW	agmatinase
GFS03_00490	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
GFS03_00495	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
GFS03_00510	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
GFS03_00535	ENOG4105NQG	DoxX
GFS03_00540	ENOG4105D5M	phosphate starvation-inducible protein
GFS03_00545	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
GFS03_00550	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
GFS03_00555	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
GFS03_00580	ENOG41086XE	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity)
GFS03_00595	ENOG4105CHU	acetyl-coa acetyltransferase
GFS03_00600	ENOG41067KJ	GYD family
GFS03_00605	ENOG4105D0M	Protease HtpX homolog
GFS03_00610	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
GFS03_00670	ENOG4107QHF	type ii secretion system protein e
GFS03_00710	ENOG4105CE4	GlcNAc 6-P deacetylase
GFS03_00715	ENOG4108JQ7	(ABC) transporter
GFS03_00720	ENOG4105C3U	ABC transporter
GFS03_00735	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
GFS03_00750	ENOG4105CXK	mandelate racemase muconate lactonizing
GFS03_00755	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
GFS03_00775	ENOG41081YG	arsenite oxidase, small subunit
GFS03_00815	ENOG4105C59	p-type ATPase
GFS03_00825	ENOG4108IUW	ABC transporter
GFS03_00850	ENOG4108RAC	Rubrerythrin
GFS03_00925	ENOG4105DZS	Phenylacetate-CoA ligase
GFS03_00935	ENOG4105CHU	acetyl-coa acetyltransferase
GFS03_00945	ENOG4108UKI	Enoyl-CoA hydratase
GFS03_00985	ENOG4108JQ7	(ABC) transporter
GFS03_01005	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GFS03_01030	ENOG41088YS	Glycosyl transferase (Group 1
GFS03_01070	ENOG4105DA5	(ABC) transporter
GFS03_01075	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
GFS03_01080	ENOG4105ETU	transcriptional activator (TenA
GFS03_01110	ENOG4105CP7	Triose-phosphate isomerase
GFS03_01125	ENOG4105BZN	citrate synthase
GFS03_01130	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
GFS03_01135	ENOG4105CR4	methylisocitrate lyase
GFS03_01140	ENOG4105DXD	2-methylcitrate dehydratase
GFS03_01145	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
GFS03_01230	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
GFS03_01235	ENOG4107QN2	dihydrolipoyl dehydrogenase
GFS03_01260	ENOG4105C5F	glutamine synthetase
GFS03_01385	ENOG410667J	hydrolase
GFS03_01390	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
GFS03_01395	ENOG4105U0R	haloacid dehalogenase-like hydrolase
GFS03_01435	ENOG4107Z60	histidine triad (HIT) protein
GFS03_01450	ENOG4108YZ4	nudix hydrolase
GFS03_01455	ENOG4107JTW	chlorite dismutase
GFS03_01470	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
GFS03_01475	ENOG4105C4K	Nad synthetase
GFS03_01500	ENOG4108D32	Methyltransferase
GFS03_01510	ENOG4107QK3	aspartate-semialdehyde dehydrogenase (EC 1.2.1.11
GFS03_01535	ENOG4108HMX	isocitrate dehydrogenase (NADP)
GFS03_01545	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
GFS03_01560	ENOG4105KZX	Pterin carbinolamine dehydratase
GFS03_01640	ENOG4105C7Z	Conserved Protein
GFS03_01650	ENOG4105ETU	transcriptional activator (TenA
GFS03_01660	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
GFS03_01685	ENOG4108K7V	UPF0284 protein
GFS03_01700	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
GFS03_01710	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
GFS03_01715	ENOG4105DXB	Major Facilitator superfamily
GFS03_01725	ENOG4105CAY	ferredoxin--nadp reductase
GFS03_01740	ENOG4105HBR	Rna-binding protein
GFS03_01785	ENOG4105K63	Thioredoxin
GFS03_01800	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
GFS03_01820	ENOG4105DU0	nucleoside hydrolase
GFS03_01835	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
GFS03_01870	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
GFS03_01875	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GFS03_01880	ENOG4108MYP	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
GFS03_01970	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
GFS03_01975	ENOG4105CHR	reductase
GFS03_02000	ENOG4105C8N	cysteinyl-tRNA synthetase
GFS03_02005	ENOG4107VCH	Bifunctional phosphoglucose phosphomannose isomerase
GFS03_02015	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
GFS03_02045	ENOG4105CHR	reductase
GFS03_02050	ENOG4105CGK	Exodeoxyribonuclease III
GFS03_02055	ENOG4105D9P	serine threonine protein kinase
GFS03_02080	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
GFS03_02090	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
GFS03_02095	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
GFS03_02100	ENOG4107XSI	cobalt-precorrin-6y C15-methyltransferase
GFS03_02110	ENOG4105E4R	Precorrin-3B C17-methyltransferase
GFS03_02115	ENOG41081F0	Precorrin-8x methylmutase
GFS03_02125	ENOG4105C5X	domain protein
GFS03_02245	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
GFS03_02250	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
GFS03_02265	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
GFS03_02285	ENOG4105D44	asparaginase
GFS03_02305	ENOG4108JIF	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
GFS03_02325	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
GFS03_02350	ENOG4107R4Q	Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity)
GFS03_02370	ENOG4107RDY	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
GFS03_02375	ENOG4105C28	cystathionine
GFS03_02420	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
GFS03_02460	ENOG4107QZ7	Cellulose synthase catalytic subunit
GFS03_02470	ENOG4105DK2	UPF0207 protein
GFS03_02475	ENOG4105DWF	phosphomethylpyrimidine kinase
GFS03_02480	ENOG4108ZAF	Molybdopterin
GFS03_02505	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
GFS03_02515	ENOG4105CJ1	ABC, transporter
GFS03_02540	ENOG4107T8T	UPF0173 metal-dependent hydrolase
GFS03_02545	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
GFS03_02575	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
GFS03_02590	ENOG4105C3M	thioredoxin reductase
GFS03_02595	ENOG4105ECY	inositol monophosphatase
GFS03_02600	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
GFS03_02640	ENOG4105EM7	Selenocysteine-specific translation elongation factor
GFS03_02675	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
GFS03_02695	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
GFS03_02720	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
GFS03_02730	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
GFS03_02735	ENOG4108RVA	ribokinase
GFS03_02740	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
GFS03_02745	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
GFS03_02750	ENOG4105EHU	Circadian clock protein KaiC
GFS03_02760	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
GFS03_02800	ENOG4105CQR	helicase
GFS03_02810	ENOG4105D8K	carboxyl transferase
GFS03_02820	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
GFS03_02840	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
GFS03_02845	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
GFS03_02850	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
GFS03_02895	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
GFS03_02915	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
GFS03_02920	ENOG4105C22	threonyL-tRNA synthetase
GFS03_02935	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
GFS03_02940	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
GFS03_02995	ENOG4105CPQ	Dehydrogenase
GFS03_03000	ENOG4105CHU	acetyl-coa acetyltransferase
GFS03_03005	ENOG4105C1G	acyl-Coa dehydrogenase
GFS03_03010	ENOG4108CCU	Ribonucleotide-diphosphate reductase subunit beta
GFS03_03015	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
GFS03_03040	ENOG4105C54	Major Facilitator superfamily
GFS03_03065	ENOG4105CEY	Amp-dependent synthetase and ligase
GFS03_03070	ENOG4105CC9	acyl-Coa dehydrogenase
GFS03_03075	ENOG4105E39	Enoyl-CoA hydratase
GFS03_03080	ENOG4105C5X	domain protein
GFS03_03105	ENOG4105ERH	Fumarylacetoacetate hydrolase
GFS03_03120	ENOG4105CEY	Amp-dependent synthetase and ligase
GFS03_03130	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
GFS03_03135	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
GFS03_03140	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
GFS03_03145	ENOG4105C54	Major Facilitator superfamily
GFS03_03155	ENOG4105CJ1	ABC, transporter
GFS03_03195	ENOG4105C26	Dehydrogenase
GFS03_03210	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
GFS03_03220	ENOG4108UKI	Enoyl-CoA hydratase
GFS03_03225	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
GFS03_03265	ENOG4105F7P	transcriptional regulator AsnC family
GFS03_03270	ENOG4105DDK	oxidoreductase, beta subunit
GFS03_03275	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
GFS03_03290	ENOG4105DAA	L-lactate
GFS03_03300	ENOG4105D3R	alkyl hydroperoxide reductase
GFS03_03325	ENOG4108JJB	ABC transporter
GFS03_03355	ENOG4105D3W	isochorismatase
GFS03_03395	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
GFS03_03400	ENOG410805Y	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
GFS03_03420	ENOG4105DDK	oxidoreductase, beta subunit
GFS03_03425	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
GFS03_03460	ENOG4105CQB	FAD linked oxidase domain protein
GFS03_03465	ENOG4105D7V	transposase
GFS03_03480	ENOG4105C26	Dehydrogenase
GFS03_03490	ENOG4105CPQ	Dehydrogenase
GFS03_03550	ENOG4105VG1	fes assembly suf system protein
GFS03_03555	ENOG4105C7K	acetolactate synthase
GFS03_03575	ENOG4105EUB	pirin domain protein
GFS03_03620	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
GFS03_03640	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
GFS03_03680	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
GFS03_03685	ENOG4105CI0	Citrate lyase
GFS03_03690	ENOG4105DRR	Transcriptional regulator, GntR family
GFS03_03715	ENOG4105DIA	mandelate racemase muconate lactonizing
GFS03_03720	ENOG4105CTX	dehydratase
GFS03_03725	ENOG4105CTX	dehydratase
GFS03_03750	ENOG4105CIG	ABC transporter
GFS03_03755	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
GFS03_03770	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
GFS03_03785	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
GFS03_03800	ENOG4108JQ7	(ABC) transporter
GFS03_03855	ENOG4105D1H	recombination factor protein RarA
GFS03_03900	ENOG4105C59	p-type ATPase
GFS03_03945	ENOG4105D7V	transposase
GFS03_03980	ENOG4108IAJ	Nad-dependent epimerase dehydratase
GFS03_03995	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
GFS03_04060	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
GFS03_04075	ENOG4105CS2	ec 3.2.1.21
GFS03_04185	ENOG4105E4P	ATPase (AAA
GFS03_04255	ENOG4107QP3	malate synthase g
GFS03_04275	ENOG4105D7V	transposase
GFS03_04315	ENOG4107RRZ	synthase
GFS03_04385	ENOG4105CH2	amidohydrolase
GFS03_04410	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
GFS03_04415	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
GFS03_04420	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
GFS03_04435	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
GFS03_04450	ENOG4105CIG	ABC transporter
GFS03_04500	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
GFS03_04555	ENOG4107PP3	Acetylornithine deacetylase
GFS03_04560	ENOG4105CSH	Transporter
GFS03_04570	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
GFS03_04575	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
GFS03_04610	ENOG4105CJ1	ABC, transporter
GFS03_04660	ENOG4105D82	Glutamate dehydrogenase
GFS03_04950	ENOG4105DTT	CRISPR-associated helicase, cas3
GFS03_04995	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
GFS03_05095	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
GFS03_05110	ENOG4108QBF	Transcriptional regulator
GFS03_05115	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
GFS03_05135	ENOG4105FUY	alpha subunit
GFS03_05140	ENOG4105FUY	alpha subunit
GFS03_05145	ENOG4108SBK	dioxygenase, subunit beta
GFS03_05155	ENOG4105JSC	dimethylmenaquinone methyltransferase
GFS03_05170	ENOG4105CSH	Transporter
GFS03_05175	ENOG4108JQ1	Dehydrogenase
GFS03_05180	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
GFS03_05230	ENOG4105E39	Enoyl-CoA hydratase
GFS03_05285	ENOG4105DSQ	Nitric oxide reductase
GFS03_05305	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
GFS03_05335	ENOG4105CEY	Amp-dependent synthetase and ligase
GFS03_05405	ENOG4105D7V	transposase
GFS03_05435	ENOG4105KRN	Transcriptional regulator, abrb family
GFS03_05455	ENOG4108JB8	alcohol dehydrogenase
GFS03_05465	ENOG4105CHR	reductase
GFS03_05475	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
GFS03_05480	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
GFS03_05490	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
GFS03_05500	ENOG4105D0M	Protease HtpX homolog
GFS03_05505	ENOG4105EHU	Circadian clock protein KaiC
GFS03_05520	ENOG4107YZX	Universal stress protein
GFS03_05525	ENOG4105VG1	fes assembly suf system protein
GFS03_05580	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
GFS03_05605	ENOG4105CD5	CoA-binding domain protein
GFS03_05625	ENOG4105DQQ	Major facilitator superfamily MFS_1
GFS03_05635	ENOG4108IUE	nitrate reductase beta subunit
GFS03_05640	ENOG4105R3A	Nitrate reductase
GFS03_05675	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
GFS03_05700	ENOG4105E39	Enoyl-CoA hydratase
GFS03_05765	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
GFS03_05770	ENOG4105PAD	Hydrolase
GFS03_05835	ENOG4105CSH	Transporter
GFS03_05840	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
GFS03_05850	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
GFS03_05855	ENOG4107QTZ	amino acid
GFS03_05860	ENOG4105D82	Glutamate dehydrogenase
GFS03_05870	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
GFS03_05910	ENOG4105EFA	4-hydroxyphenylacetate
GFS03_05935	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
GFS03_05940	ENOG4105C1G	acyl-Coa dehydrogenase
GFS03_05950	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
GFS03_05980	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
GFS03_05985	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GFS03_06000	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
GFS03_06050	ENOG4105CDZ	Carboxymethylenebutenolidase (EC 3.1.1.45)
GFS03_06090	ENOG4105D7V	transposase
GFS03_06100	ENOG4107RE3	peptidase, S41
GFS03_06105	ENOG4105WCJ	ec 1.1.1.193
GFS03_06110	ENOG4107QTZ	amino acid
GFS03_06130	ENOG4105CHM	Aminotransferase
GFS03_06145	ENOG4105FEU	K -dependent Na -Ca exchanger
GFS03_06170	ENOG4105EG2	ABC transporter, permease
GFS03_06185	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
GFS03_06200	ENOG4105C1G	acyl-Coa dehydrogenase
GFS03_06215	ENOG4105CC9	acyl-Coa dehydrogenase
GFS03_06250	ENOG4105CSH	Transporter
GFS03_06255	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
GFS03_06260	ENOG4105CJ1	ABC, transporter
GFS03_06300	ENOG41086B8	CoB-CoM heterodisulfide reductase
GFS03_06315	ENOG4107QN2	dihydrolipoyl dehydrogenase
GFS03_06330	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
GFS03_06335	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
GFS03_06345	ENOG4107QN2	dihydrolipoyl dehydrogenase
GFS03_06390	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
GFS03_06395	ENOG4105K4P	CoA-binding domain protein
GFS03_06430	ENOG4105RQ5	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
GFS03_06440	ENOG4105CSP	Major Facilitator Superfamily
GFS03_06480	ENOG4107QM5	aconitate hydratase
GFS03_06500	ENOG4108R1E	Serine threonine protein phosphatase 1
GFS03_06535	ENOG41090MY	MarR family Transcriptional regulator
GFS03_06540	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
GFS03_06550	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
GFS03_06555	ENOG4105C9Q	fumarate hydratase class II
GFS03_06565	ENOG41080XP	Cbs domain
GFS03_06570	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
GFS03_06575	ENOG4108Z0Z	intracellular protease Pfpi family
GFS03_06585	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
GFS03_06590	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
GFS03_06610	ENOG4108UR0	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
GFS03_06615	ENOG4105DF9	Lipoate-protein, ligase
GFS03_06645	ENOG4105BZU	Histidine kinase
GFS03_06670	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
GFS03_06715	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
GFS03_06730	ENOG4105M7V	2'-5' rna ligase
GFS03_06760	ENOG4107Z6A	sulfate abc transporter permease
GFS03_06785	ENOG4107TDF	Formate hydrogenlyase subunit 4
GFS03_06795	ENOG4108JPZ	Monovalent cation H antiporter subunit D
GFS03_06800	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GFS03_06805	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GFS03_06810	ENOG4108JPZ	Monovalent cation H antiporter subunit D
GFS03_06820	ENOG4105KHC	sulfurtransferase
GFS03_06825	ENOG4105D9G	High-affinity
GFS03_06895	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
GFS03_06900	ENOG4105I1K	ABC transporter
GFS03_06915	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
GFS03_06920	ENOG4108IYU	L-aspartate oxidase
GFS03_06925	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
GFS03_06955	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
GFS03_06965	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
GFS03_06975	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
GFS03_06985	ENOG4105CA9	Pyruvate kinase
GFS03_06995	ENOG4105E66	phosphoriboisomerase A
GFS03_07005	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
GFS03_07015	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
GFS03_07025	ENOG4105CHR	reductase
GFS03_07040	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GFS03_07055	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GFS03_07085	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
GFS03_07125	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
GFS03_07140	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
GFS03_07160	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
GFS03_07195	ENOG4108K3F	N(2),N(2)-dimethylguanosine tRNA methyltransferase
GFS03_07225	ENOG4105HDK	L-asparaginase
GFS03_07230	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
GFS03_07275	ENOG4105C3K	feS assembly ATPase SufC
GFS03_07295	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
GFS03_07310	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFS03_07350	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
GFS03_07355	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
GFS03_07370	ENOG4108JQ1	Dehydrogenase
GFS03_07375	ENOG4105GRF	N-glycosylase DNA lyase
GFS03_07415	ENOG4105CHM	Aminotransferase
GFS03_07420	ENOG4105DK0	Indole-3-glycerol phosphate synthase
GFS03_07425	ENOG4105DDQ	anthranilate synthase
GFS03_07430	ENOG4105CRQ	synthase (Component I)
GFS03_07435	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
GFS03_07440	ENOG4108I0Q	anthranilate phosphoribosyltransferase
GFS03_07445	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
GFS03_07450	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
GFS03_07455	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
GFS03_07460	ENOG4105CZA	synthase
GFS03_07470	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
GFS03_07485	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
GFS03_07490	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
GFS03_07495	ENOG4105CFH	Aspartokinase
GFS03_07500	ENOG4107QK3	aspartate-semialdehyde dehydrogenase (EC 1.2.1.11
GFS03_07515	ENOG4105DBV	ornithine carbamoyltransferase
GFS03_07610	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
GFS03_07670	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
GFS03_07675	ENOG4105D1H	recombination factor protein RarA
GFS03_07685	ENOG4108V1U	phospholipid-binding protein
GFS03_07690	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
GFS03_07695	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
GFS03_07700	ENOG4105CPQ	Dehydrogenase
GFS03_07725	ENOG4105CY0	Metallo-Beta-Lactamase
GFS03_07735	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
GFS03_07755	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
GFS03_07800	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
GFS03_07835	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
GFS03_07840	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
GFS03_07845	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
GFS03_07855	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
GFS03_07900	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
GFS03_07905	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
GFS03_07935	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
GFS03_07955	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
GFS03_07960	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
GFS03_07985	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GFS03_07990	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
GFS03_08000	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
GFS03_08005	ENOG4108FGF	50s ribosomal protein l29
GFS03_08015	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
GFS03_08020	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
GFS03_08025	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
GFS03_08035	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GFS03_08045	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
GFS03_08050	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
GFS03_08070	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
GFS03_08325	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
GFS03_08335	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
GFS03_08345	ENOG4105CBC	glutamate synthase
GFS03_08350	ENOG4105EYU	Glutamine amido-transferase
GFS03_08365	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
GFS03_08375	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
GFS03_08380	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
GFS03_08425	ENOG4105D1Z	hydroxypyruvate reductase
GFS03_08430	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GFS03_08435	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
GFS03_08440	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
GFS03_08455	ENOG4105MRR	Transcriptional regulator (By similarity)
GFS03_08470	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
GFS03_08480	ENOG4105E39	Enoyl-CoA hydratase
GFS03_08515	ENOG4105F35	Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity)
GFS03_08525	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
GFS03_08535	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
GFS03_08540	ENOG4105CH7	arginosuccinase
GFS03_08545	ENOG4105CDH	Citrulline--aspartate ligase
GFS03_08560	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
GFS03_08565	ENOG4105C12	Phosphoribosylglycinamide synthetase
GFS03_08580	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
GFS03_08585	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
GFS03_08595	ENOG4105C8V	SAICAR synthetase
GFS03_08600	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
GFS03_08605	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GFS03_08610	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
GFS03_08645	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
GFS03_08650	ENOG4107YIW	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
GFS03_08660	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
GFS03_08670	ENOG4105CD3	dihydroorotase
GFS03_08675	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
GFS03_08690	ENOG41081FY	multiple antibiotic resistance (MarC)-related
GFS03_08695	ENOG4108VVK	transcriptional Regulator, AsnC
GFS03_08710	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
GFS03_08715	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
GFS03_08720	ENOG4105VG1	fes assembly suf system protein
GFS03_08730	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
GFS03_08735	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
GFS03_08740	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
GFS03_08745	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
GFS03_08750	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
GFS03_08755	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
GFS03_08760	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
GFS03_08765	ENOG4105CIH	Imidazole acetol-phosphate transaminase
GFS03_08775	ENOG4105C8T	Leucyl-tRNA synthetase
GFS03_08780	ENOG4108WBT	adenosyltransferase
GFS03_08785	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
GFS03_08795	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
GFS03_08820	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
GFS03_08825	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
GFS03_08830	ENOG4105C7K	acetolactate synthase
GFS03_08840	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
GFS03_08855	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
GFS03_08860	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
GFS03_08870	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
GFS03_08885	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
GFS03_08890	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
GFS03_08895	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
GFS03_08915	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
GFS03_08945	ENOG4105CQ2	DNA polymerase
GFS03_08970	ENOG4105BZA	Phosphoglycerate kinase
GFS03_08980	ENOG4107YZX	Universal stress protein
GFS03_08985	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
GFS03_09005	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
GFS03_09010	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
GFS03_09065	ENOG4105C8T	Leucyl-tRNA synthetase
GFS03_09130	ENOG4105FDK	ABC transporter
GFS03_09145	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
GFS03_09170	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
GFS03_09180	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
GFS03_09190	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
GFS03_09195	ENOG4107QPD	alcohol dehydrogenase
GFS03_09205	ENOG4105EM7	Selenocysteine-specific translation elongation factor
GFS03_09225	ENOG4107ZCS	Phosphomethylpyrimidine kinase
GFS03_09230	ENOG4105EYF	MMPL domain protein
GFS03_09255	ENOG4105D1F	ATP-binding protein
GFS03_09290	ENOG4105C31	Tryptophanyl-tRNA synthetase
GFS03_09305	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
GFS03_09350	ENOG4105CYW	agmatinase
GFS03_09355	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
GFS03_09385	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
GFS03_09395	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
GFS03_09420	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
GFS03_09425	ENOG4105CPC	Aldo Keto reductase
GFS03_09470	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
GFS03_09475	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
GFS03_09480	ENOG4105E3H	phosphoglycerate mutase
GFS03_09505	ENOG4105EM7	Selenocysteine-specific translation elongation factor
GFS03_09515	ENOG4105DAT	cobalamin (vitamin b12) biosynthesis cbix protein
GFS03_09525	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
GFS03_09540	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
GFS03_09550	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
GFS03_09560	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
GFS03_09570	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
GFS03_09590	ENOG4107QRT	dEAD DEAH box helicase
GFS03_09600	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
GFS03_09605	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
GFS03_09610	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
GFS03_09620	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
GFS03_09655	ENOG4108SHN	Glycosyl transferase, family 2
GFS03_09675	ENOG4105CN5	Metallo-Beta-Lactamase
GFS03_09680	ENOG4105C22	threonyL-tRNA synthetase
GFS03_09690	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
GFS03_09695	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
GFS03_09720	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
GFS03_09730	ENOG4108Z0R	Transferase
GFS03_09735	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
GFS03_09745	ENOG4105CEY	Amp-dependent synthetase and ligase
GFS03_09750	ENOG4105K63	Thioredoxin
GFS03_09755	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
GFS03_09760	ENOG4105C5F	glutamine synthetase
GFS03_09780	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
GFS03_09795	ENOG4105C6T	cysteine synthase
GFS03_09860	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
GFS03_09875	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
GFS03_09885	ENOG41081WB	50s ribosomal protein L10
GFS03_09895	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
GFS03_09925	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
GFS03_09930	ENOG4105CZA	synthase
GFS03_09935	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GFS03_09940	ENOG4105D65	subunit l
GFS03_09945	ENOG41082X4	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GFS03_09955	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GFS03_09960	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
GFS03_09965	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GFS03_09970	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GFS03_09980	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
GFS03_10005	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
GFS03_10055	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
GFS03_10060	ENOG4105E2X	shikimate dehydrogenase
GFS03_10065	ENOG4105D49	3-dehydroquinate synthase
GFS03_10070	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
GFS03_10075	ENOG4105CQC	Prephenate dehydratase
GFS03_10080	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
GFS03_10085	ENOG4108HHA	Transketolase
GFS03_10110	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
GFS03_10145	ENOG41079KZ	Major Facilitator Superfamily
GFS03_10155	ENOG4105FDK	ABC transporter
GFS03_10160	ENOG4107NFR	Fructose-1,6-bisphosphatase
GFS03_10185	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
GFS03_10200	ENOG4105CUT	histidyl-tRNA synthetase
GFS03_10235	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
GFS03_10245	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
GFS03_10290	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
GFS03_10355	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
GFS03_10375	ENOG4105C7B	Threonine dehydratase
GFS03_10380	ENOG4105CQC	Prephenate dehydratase
GFS03_10385	ENOG4108UMR	transcriptional regulator AsnC family
GFS03_10395	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
GFS03_10410	ENOG4105C83	adenylosuccinate lyase
GFS03_10425	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
GFS03_10440	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
GFS03_10445	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
GFS03_10450	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
GFS03_10465	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
GFS03_10480	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
GFS03_10485	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
GFS03_10490	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
GFS03_10515	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
GFS03_10520	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
GFS03_10525	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
GFS03_10570	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
GFS03_10580	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
GFS03_10600	ENOG4108VA3	3-hexulose-6-phosphate synthase
GFS03_10605	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
GFS03_10620	ENOG4105DZH	s-adenosylmethionine synthetase (EC 2.5.1.6)
GFS03_10650	ENOG4105NBF	ammecr1 domain protein
GFS03_10665	ENOG4105DHP	deoxycytidine triphosphate deaminase
GFS03_10670	ENOG4107TRG	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
GFS03_10680	ENOG4108DN8	FAD dependent oxidoreductase
GFS03_10705	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
GFS03_10710	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
GFS03_10715	ENOG4105D52	delta-aminolevulinic acid dehydratase
GFS03_10720	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
GFS03_10740	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
GFS03_10760	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
GFS03_10765	ENOG4105C5S	asparaginyl-tRNA synthetase
GFS03_10790	ENOG4105C7K	acetolactate synthase
GFS03_10805	ENOG4108JJB	ABC transporter
GFS03_10830	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
GFS03_10835	ENOG4108KB0	deacetylase
GFS03_10840	ENOG4105C8Y	Acetylornithine aminotransferase
GFS03_10845	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
GFS03_10860	ENOG4107U4Q	acetylglutamate kinase
GFS03_10865	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
GFS03_10880	ENOG41080HJ	6-phospho 3-hexuloisomerase
GFS03_10945	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
GFS03_10950	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
GFS03_10965	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
GFS03_11000	ENOG4105CSM	endonuclease III
GFS03_11015	ENOG4107QRT	dEAD DEAH box helicase
GFS03_11025	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
GFS03_11050	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
GFS03_11055	ENOG4105CEV	competence damage-inducible protein
GFS03_11070	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
GFS03_11075	ENOG4105E8R	UPF0173 metal-dependent hydrolase
GFS03_11100	ENOG4105DCI	Phosphohydrolase
GFS03_11125	ENOG4105CRK	lysyL-tRNA synthetase
GFS03_11155	ENOG4108YM7	Gcn5-related n-acetyltransferase
GFS03_11170	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
GFS03_11185	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GFS03_11190	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
GFS03_11195	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
GFS03_11210	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
GFS03_11215	ENOG4108UJD	30S ribosomal protein S9
GFS03_11225	ENOG4105CE9	30S ribosomal protein S2
GFS03_11230	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
GFS03_11245	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
GFS03_11255	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
GFS03_11315	ENOG4105VUN	Transcriptional regulator
GFS03_11330	ENOG4105F8V	Hydrolase, tatD family
GFS03_11380	ENOG4107QJE	Chromosome Partitioning Protein
GFS03_11400	ENOG41080XQ	Signal transduction protein with cbs domains
GFS03_11405	ENOG4105DGU	Histone deacetylase
GFS03_11410	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
GFS03_11445	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
GFS03_11455	ENOG4107QRT	dEAD DEAH box helicase
GFS03_11465	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
GFS03_11490	ENOG4105EN6	Membrane
GFS03_11525	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
GFS03_11530	ENOG4108RVA	ribokinase
GFS03_11535	ENOG4105DWF	phosphomethylpyrimidine kinase
GFS03_11545	ENOG4105CND	Glycosyl transferase, family 2
GFS03_11615	ENOG4105CPQ	Dehydrogenase
GFS03_11620	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
GFS03_11630	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
GFS03_11635	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
GFS03_11640	ENOG4105D0M	Protease HtpX homolog
GFS03_11645	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
GFS03_11655	ENOG41061GT	Aldolase
GFS03_11680	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
GFS03_11695	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
GFS03_11710	ENOG4105C8Y	Acetylornithine aminotransferase
GFS03_11720	ENOG4108FN7	Aldo keto reductase
GFS03_11735	ENOG4105KME	endoribonuclease L-psp
GFS03_11740	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
GFS03_11745	ENOG4105E2A	Dehydrogenase
GFS03_11750	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
GFS03_11775	ENOG4105CXK	mandelate racemase muconate lactonizing
GFS03_11780	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
GFS03_11785	ENOG4105EDK	PfkB domain protein
GFS03_11790	ENOG4105C26	Dehydrogenase
GFS03_11795	ENOG4105FEU	K -dependent Na -Ca exchanger
GFS03_11800	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
GFS03_11835	ENOG4107YZX	Universal stress protein
GFS03_11840	ENOG4105D9P	serine threonine protein kinase
GFS03_11850	ENOG4107RGD	Major Facilitator superfamily
GFS03_11875	ENOG4105KVH	Transcriptional regulator
GFS03_11885	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
GFS03_11890	ENOG4108R96	Methyltransferase, YaeB family
GFS03_11940	ENOG4105CQB	FAD linked oxidase domain protein
GFS03_11945	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
GFS03_11950	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
GFS03_11955	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
GFS03_11970	ENOG4105CS1	NAD(P)H quinone oxidoreductase
GFS03_11990	ENOG4107QN2	dihydrolipoyl dehydrogenase
GFS03_11995	ENOG4105CSH	Transporter
GFS03_12045	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
GFS03_12055	ENOG4105C5X	domain protein
GFS03_12095	ENOG4105CXK	mandelate racemase muconate lactonizing
GFS03_12105	ENOG4105CSH	Transporter
GFS03_12110	ENOG4105C54	Major Facilitator superfamily
GFS03_12125	ENOG4107RCM	Releases the N-terminal proline from various substrates (By similarity)
GFS03_12135	ENOG4105CHR	reductase
GFS03_12165	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
GFS03_12180	ENOG4105CTD	carboxy-peptidase
GFS03_12220	ENOG4105EY8	ABC transporter
GFS03_12260	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
GFS03_12280	ENOG4105FDK	ABC transporter
GFS03_12325	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
GFS03_12335	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
GFS03_12345	ENOG4105HS6	binding-protein-dependent transport systems inner membrane Component
GFS03_12355	ENOG4105CEY	Amp-dependent synthetase and ligase
GFS03_12395	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
GFS03_12465	ENOG4108JQ7	(ABC) transporter
GFS03_12480	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
GFS03_12495	ENOG4105CNT	hydrolase family 2
GFS03_12500	ENOG4105DIA	mandelate racemase muconate lactonizing
GFS03_12505	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
GFS03_12515	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
GFS03_12555	ENOG4105EQX	glucarate dehydratase
GFS03_12560	ENOG4105D7V	transposase
GFS03_12605	ENOG4105CPC	Aldo Keto reductase
GFS03_12615	ENOG4105BZ1	(ABC) transporter
GFS03_12650	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
GFS03_12670	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
GFS03_12675	ENOG4105CXK	mandelate racemase muconate lactonizing
GFS03_12680	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
GFS03_12685	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
GFS03_12760	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
GFS03_12785	ENOG4105BZ9	Cytochrome C oxidase, subunit I
GFS03_12800	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
GFS03_12860	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
GFS03_12890	ENOG4105DHP	deoxycytidine triphosphate deaminase
GFS03_12915	ENOG4105RE0	Asp Glu hydantoin racemase
GFS03_12935	ENOG4107U7N	hydantoinase B oxoprolinase
GFS03_12960	ENOG4107RIQ	Sulfate adenylate transferase
GFS03_12970	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
GFS03_12975	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
GFS03_12980	ENOG4105KHC	sulfurtransferase
GFS03_13035	ENOG4108FN7	Aldo keto reductase
GFS03_13050	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
GFS03_13060	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
GFS03_13070	ENOG4105C1G	acyl-Coa dehydrogenase
GFS03_13075	ENOG4105CEY	Amp-dependent synthetase and ligase
GFS03_13080	ENOG4105CHU	acetyl-coa acetyltransferase
GFS03_13090	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
GFS03_13100	ENOG4105C6K	Malic enzyme
GFS03_13130	ENOG4106HK8	GPR1 FUN34 yaaH family protein
GFS03_13135	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
GFS03_13175	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
GFS03_13180	ENOG4105I1K	ABC transporter
GFS03_13200	ENOG4105C0Z	ABC transporter
GFS03_13205	ENOG4108IV0	ABC, transporter
GFS03_13230	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)