locus-tag	class	description
D1869_00020	ENOG4105CB5	ATP-dependent DNA helicase recG
D1869_00085	ENOG4105C5F	glutamine synthetase
D1869_00195	ENOG4105DA5	(ABC) transporter
D1869_00270	ENOG4105CIH	Imidazole acetol-phosphate transaminase
D1869_00280	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
D1869_00325	ENOG4105D1F	ATP-binding protein
D1869_00365	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
D1869_00370	ENOG4107TSN	permease
D1869_00390	ENOG4108IAJ	Nad-dependent epimerase dehydratase
D1869_00415	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
D1869_00420	ENOG4108KB0	deacetylase
D1869_00425	ENOG4105C8Y	Acetylornithine aminotransferase
D1869_00430	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
D1869_00445	ENOG4105CAS	nag kinase
D1869_00450	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
D1869_00465	ENOG41080HJ	6-phospho 3-hexuloisomerase
D1869_00505	ENOG4105C7K	acetolactate synthase
D1869_00530	ENOG4105C5S	asparaginyl-tRNA synthetase
D1869_00535	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
D1869_00555	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
D1869_00570	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
D1869_00575	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
D1869_00580	ENOG4105D52	delta-aminolevulinic acid dehydratase
D1869_00585	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
D1869_00590	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
D1869_00615	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
D1869_00625	ENOG4107TRG	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
D1869_00630	ENOG4105DHP	deoxycytidine triphosphate deaminase
D1869_00645	ENOG4105NBF	ammecr1 domain protein
D1869_00675	ENOG4105DZH	s-adenosylmethionine synthetase (EC 2.5.1.6)
D1869_00690	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
D1869_00695	ENOG4108VA3	3-hexulose-6-phosphate synthase
D1869_00715	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
D1869_00725	ENOG4105VUC	UPF0237 protein
D1869_00730	ENOG4105CAG	UPF0210 protein
D1869_00785	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
D1869_00830	ENOG4105CIG	ABC transporter
D1869_00855	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
D1869_00860	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
D1869_00865	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
D1869_00885	ENOG4105XPM	ribosomal protein
D1869_00890	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
D1869_00895	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
D1869_00900	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
D1869_00910	ENOG4105C6K	Malic enzyme
D1869_00915	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
D1869_00920	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
D1869_00935	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
D1869_00940	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
D1869_00945	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
D1869_00960	ENOG4105WCJ	ec 1.1.1.193
D1869_00965	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
D1869_00980	ENOG4105C83	adenylosuccinate lyase
D1869_00995	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
D1869_01000	ENOG4105DZ0	fad dependent oxidoreductase
D1869_01010	ENOG4105CQC	Prephenate dehydratase
D1869_01015	ENOG4105C7B	Threonine dehydratase
D1869_01035	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
D1869_01055	ENOG4105NAU	thioesterase Superfamily protein
D1869_01095	ENOG4108RTE	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity)
D1869_01130	ENOG4108FPN	Integrase
D1869_01180	ENOG4105FDK	ABC transporter
D1869_01185	ENOG4107NFR	Fructose-1,6-bisphosphatase
D1869_01210	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
D1869_01225	ENOG4105CUT	histidyl-tRNA synthetase
D1869_01245	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
D1869_01260	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
D1869_01270	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
D1869_01300	ENOG4105CSH	Transporter
D1869_01310	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
D1869_01335	ENOG4105CY0	Metallo-Beta-Lactamase
D1869_01340	ENOG4108MDK	Dehydrogenase
D1869_01345	ENOG4108YZY	peptidylprolyl cis-trans isomerase
D1869_01355	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
D1869_01410	ENOG4108IUX	(ABC) transporter
D1869_01435	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
D1869_01440	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
D1869_01445	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
D1869_01470	ENOG4108ZJT	translation initiation factor, Sui1
D1869_01485	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
D1869_01515	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
D1869_01525	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
D1869_01540	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
D1869_01550	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
D1869_01555	ENOG4105CPC	Aldo Keto reductase
D1869_01600	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
D1869_01605	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
D1869_01610	ENOG4105E3H	phosphoglycerate mutase
D1869_01635	ENOG4105EM7	Selenocysteine-specific translation elongation factor
D1869_01645	ENOG4105DAT	cobalamin (vitamin b12) biosynthesis cbix protein
D1869_01655	ENOG4107QYE	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
D1869_01660	ENOG4107QYE	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
D1869_01670	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
D1869_01690	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
D1869_01720	ENOG4107QRT	dEAD DEAH box helicase
D1869_01735	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
D1869_01740	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
D1869_01750	ENOG41088YS	Glycosyl transferase (Group 1
D1869_01795	ENOG4105CAT	Cytidine monophosphate kinase
D1869_01820	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
D1869_01830	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
D1869_01850	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
D1869_01855	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
D1869_01865	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1869_01880	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
D1869_01900	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
D1869_01905	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
D1869_01910	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
D1869_01915	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1869_01920	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
D1869_01925	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
D1869_01945	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
D1869_01965	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
D1869_01970	ENOG4105C3M	thioredoxin reductase
D1869_01975	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
D1869_02005	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
D1869_02045	ENOG4105C3G	gtp-binding protein
D1869_02050	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
D1869_02060	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
D1869_02065	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
D1869_02070	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
D1869_02120	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
D1869_02180	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
D1869_02185	ENOG4105D1H	recombination factor protein RarA
D1869_02195	ENOG4108V1U	phospholipid-binding protein
D1869_02200	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
D1869_02205	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
D1869_02215	ENOG4105CPQ	Dehydrogenase
D1869_02240	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
D1869_02245	ENOG4107USC	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
D1869_02255	ENOG4105EAH	synthase
D1869_02260	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
D1869_02265	ENOG4108VVK	transcriptional Regulator, AsnC
D1869_02295	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
D1869_02325	ENOG41086B8	CoB-CoM heterodisulfide reductase
D1869_02340	ENOG4107R4Q	Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity)
D1869_02355	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
D1869_02360	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
D1869_02365	ENOG4105C28	cystathionine
D1869_02410	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
D1869_02470	ENOG4108ZAF	Molybdopterin
D1869_02535	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
D1869_02585	ENOG4105ECY	inositol monophosphatase
D1869_02590	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
D1869_02605	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
D1869_02630	ENOG4105EM7	Selenocysteine-specific translation elongation factor
D1869_02645	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
D1869_02665	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
D1869_02710	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
D1869_02720	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
D1869_02725	ENOG4108RVA	ribokinase
D1869_02735	ENOG4108Z4K	mutator MutT protein
D1869_02740	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
D1869_02745	ENOG4105EHU	Circadian clock protein KaiC
D1869_02755	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
D1869_02760	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
D1869_02770	ENOG4105D3R	alkyl hydroperoxide reductase
D1869_02785	ENOG4105BZN	citrate synthase
D1869_02805	ENOG4105CQR	helicase
D1869_02815	ENOG4105D8K	carboxyl transferase
D1869_02825	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
D1869_02835	ENOG4105D7T	ABC transporter
D1869_02850	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
D1869_02855	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
D1869_02860	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
D1869_02865	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
D1869_02895	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
D1869_02920	ENOG4105BZ9	Cytochrome C oxidase, subunit I
D1869_02995	ENOG4105C8T	Leucyl-tRNA synthetase
D1869_03005	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
D1869_03025	ENOG4107R56	PP-loop domain protein
D1869_03035	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
D1869_03070	ENOG4108JB9	formate dehydrogenase
D1869_03115	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
D1869_03120	ENOG4105CQB	FAD linked oxidase domain protein
D1869_03130	ENOG4105CEP	NADH dehydrogenase
D1869_03180	ENOG4105BZU	Histidine kinase
D1869_03205	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
D1869_03220	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
D1869_03290	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
D1869_03305	ENOG4107QPV	Serine Threonine protein kinase
D1869_03310	ENOG4107QN2	dihydrolipoyl dehydrogenase
D1869_03350	ENOG4107QNK	)-transporter
D1869_03390	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
D1869_03405	ENOG4108JQ7	(ABC) transporter
D1869_03410	ENOG4105C3U	ABC transporter
D1869_03415	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
D1869_03435	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
D1869_03470	ENOG4108M14	stage v sporulation protein t
D1869_03480	ENOG4105D2S	major facilitator superfamily
D1869_03525	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1869_03545	ENOG4105EFA	4-hydroxyphenylacetate
D1869_03560	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
D1869_03565	ENOG4106HK8	GPR1 FUN34 yaaH family protein
D1869_03570	ENOG41067KJ	GYD family
D1869_03585	ENOG4105C8Y	Acetylornithine aminotransferase
D1869_03620	ENOG4105VG1	fes assembly suf system protein
D1869_03675	ENOG4105C7K	acetolactate synthase
D1869_03680	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
D1869_03705	ENOG4108IUW	ABC transporter
D1869_03785	ENOG41080XP	Cbs domain
D1869_03800	ENOG4105CS2	ec 3.2.1.21
D1869_03810	ENOG41089UC	methyltransferase, type 11
D1869_03830	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
D1869_03850	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
D1869_03885	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
D1869_03895	ENOG4105DIK	(ABC) transporter
D1869_03925	ENOG4107QM5	aconitate hydratase
D1869_03955	ENOG4105T58	Dithiol-disulfide isomerase
D1869_03985	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
D1869_03995	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
D1869_04005	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
D1869_04020	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
D1869_04030	ENOG4105KME	endoribonuclease L-psp
D1869_04040	ENOG4105D9P	serine threonine protein kinase
D1869_04055	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
D1869_04060	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
D1869_04145	ENOG4105CZV	ABC transporter
D1869_04260	ENOG4106A3M	Cytochrome p-450
D1869_04295	ENOG4105C0D	helicase
D1869_04340	ENOG4107QRT	dEAD DEAH box helicase
D1869_04395	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
D1869_04405	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
D1869_04455	ENOG4108J8C	transporter major facilitator family protein
D1869_04485	ENOG4108Z0Z	intracellular protease Pfpi family
D1869_04490	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
D1869_04535	ENOG41084XP	SirA-like domain-containing protein
D1869_04595	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
D1869_04600	ENOG4105CS1	NAD(P)H quinone oxidoreductase
D1869_04665	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
D1869_04705	ENOG4105CUB	amino acid
D1869_04740	ENOG41089BK	Glutamine amido-transferase
D1869_04785	ENOG4105FDK	ABC transporter
D1869_04790	ENOG4108I9K	permease protein
D1869_04825	ENOG4105D0M	Protease HtpX homolog
D1869_05075	ENOG4108EQM	faD-dependent pyridine nucleotide-disulfide oxidoreductase
D1869_05095	ENOG4105BZP	glycoside hydrolase 15-related
D1869_05100	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
D1869_05115	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
D1869_05175	ENOG4107QNK	)-transporter
D1869_05180	ENOG4105CHR	reductase
D1869_05200	ENOG4105CEY	Amp-dependent synthetase and ligase
D1869_05230	ENOG4105CYW	agmatinase
D1869_05245	ENOG4105CXK	mandelate racemase muconate lactonizing
D1869_05260	ENOG4105EG2	ABC transporter, permease
D1869_05325	ENOG4108IPJ	Membrane
D1869_05350	ENOG4105K8R	UPF0145 protein
D1869_05430	ENOG4105DIK	(ABC) transporter
D1869_05475	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
D1869_05490	ENOG4107ZMQ	sugar fermentation stimulation protein
D1869_05580	ENOG4105E3S	small subunit
D1869_05615	ENOG4105C8H	hydrogenase maturation protein Hypf
D1869_05625	ENOG4105KVH	Transcriptional regulator
D1869_05630	ENOG4105DPX	Hydrogenase, large subunit
D1869_05660	ENOG4107R0P	L-ribulose-5-phosphate 4-epimerase
D1869_05685	ENOG4105DPX	Hydrogenase, large subunit
D1869_05730	ENOG4108JJB	ABC transporter
D1869_05765	ENOG4105D5T	phosphonate abc transporter
D1869_05790	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
D1869_05830	ENOG4105CEU	Arginine dihydrolase
D1869_05840	ENOG4107S2W	Nitric oxide dioxygenase
D1869_05850	ENOG4105DQQ	Major facilitator superfamily MFS_1
D1869_05870	ENOG4108YZ9	Urea amidohydrolase subunit gamma
D1869_05875	ENOG4105CQM	Urea amidohydrolase subunit alpha
D1869_05890	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
D1869_05900	ENOG4108V7B	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity)
D1869_05905	ENOG4105EW9	transcriptional regulator AsnC family
D1869_05950	ENOG4105C5F	glutamine synthetase
D1869_05985	ENOG4108V7B	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity)
D1869_06035	ENOG4105DZC	cytosine deaminase
D1869_06070	ENOG4108M15	ABC transporter
D1869_06085	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
D1869_06095	ENOG4105C8I	hydrolase, family 38
D1869_06100	ENOG4105DWF	phosphomethylpyrimidine kinase
D1869_06105	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
D1869_06130	ENOG4108ZKT	aldose 1-epimerase
D1869_06175	ENOG4108SZE	gCN5-related N-acetyltransferase
D1869_06200	ENOG4105E4P	ATPase (AAA
D1869_06285	ENOG4105DCI	Phosphohydrolase
D1869_06290	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
D1869_06300	ENOG4105CPK	Glycosyl transferase (Group 1
D1869_06305	ENOG4105BZP	glycoside hydrolase 15-related
D1869_06315	ENOG4105CEP	NADH dehydrogenase
D1869_06395	ENOG4105EJZ	Glucose-1-phosphate cytidylyltransferase
D1869_06405	ENOG4105C22	threonyL-tRNA synthetase
D1869_06420	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
D1869_06425	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
D1869_06460	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
D1869_06465	ENOG4105DB1	molybdopterin oxidoreductase
D1869_06485	ENOG4105C45	hydrogenase expression formation protein (HypE)
D1869_06495	ENOG4105CQS	hydrogenase expression formation protein HypD
D1869_06510	ENOG4105DPX	Hydrogenase, large subunit
D1869_06555	ENOG4105M7V	2'-5' rna ligase
D1869_06580	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
D1869_06615	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
D1869_06645	ENOG4108RE7	deoxyribonuclease
D1869_06655	ENOG4105JHE	Major Facilitator Superfamily
D1869_06710	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
D1869_06730	ENOG4105C1G	acyl-Coa dehydrogenase
D1869_06755	ENOG4105C54	Major Facilitator superfamily
D1869_06770	ENOG4107RE3	peptidase, S41
D1869_06790	ENOG4107TE1	transport protein
D1869_06855	ENOG4108EHY	type IV secretion system
D1869_06965	ENOG4108IYU	L-aspartate oxidase
D1869_06970	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
D1869_06975	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
D1869_06995	ENOG4105DIW	FeS assembly protein SUFB
D1869_07000	ENOG4105C3K	feS assembly ATPase SufC
D1869_07020	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
D1869_07025	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
D1869_07030	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1869_07035	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1869_07075	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
D1869_07080	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
D1869_07095	ENOG4108JQ1	Dehydrogenase
D1869_07100	ENOG4105GRF	N-glycosylase DNA lyase
D1869_07130	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
D1869_07135	ENOG4105CHM	Aminotransferase
D1869_07145	ENOG4105DDQ	anthranilate synthase
D1869_07150	ENOG4105CRQ	synthase (Component I)
D1869_07155	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
D1869_07160	ENOG4108I0Q	anthranilate phosphoribosyltransferase
D1869_07165	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
D1869_07170	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
D1869_07175	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
D1869_07190	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
D1869_07215	ENOG4105CFH	Aspartokinase
D1869_07220	ENOG4107QK3	aspartate-semialdehyde dehydrogenase (EC 1.2.1.11
D1869_07225	ENOG4105C0B	DNA polymerase III (alpha subunit)
D1869_07235	ENOG4105DBV	ornithine carbamoyltransferase
D1869_07270	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
D1869_07305	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
D1869_07320	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
D1869_07325	ENOG4105HDK	L-asparaginase
D1869_07355	ENOG4108K3F	N(2),N(2)-dimethylguanosine tRNA methyltransferase
D1869_07405	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
D1869_07420	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
D1869_07425	ENOG410855J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
D1869_07430	ENOG4105VF7	tolerance protein
D1869_07465	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
D1869_07475	ENOG4107QRT	dEAD DEAH box helicase
D1869_07520	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
D1869_07540	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
D1869_07555	ENOG4105E66	phosphoriboisomerase A
D1869_07595	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
D1869_07620	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
D1869_07625	ENOG4107YZX	Universal stress protein
D1869_07635	ENOG4105BZA	Phosphoglycerate kinase
D1869_07680	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
D1869_07690	ENOG4108VZM	50s ribosomal protein L10
D1869_07700	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
D1869_07715	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
D1869_07780	ENOG4105C6T	cysteine synthase
D1869_07795	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
D1869_07800	ENOG4105DC7	peptidase M24
D1869_07805	ENOG4105EUJ	GTP cyclohydrolase i
D1869_07815	ENOG4105C5F	glutamine synthetase
D1869_07820	ENOG4105K63	Thioredoxin
D1869_07825	ENOG4105CEY	Amp-dependent synthetase and ligase
D1869_07835	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
D1869_07840	ENOG4108Z0R	Transferase
D1869_07850	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
D1869_07870	ENOG4107QHF	type ii secretion system protein e
D1869_07895	ENOG4105CSM	endonuclease III
D1869_07910	ENOG4107QRT	dEAD DEAH box helicase
D1869_07945	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
D1869_07950	ENOG4105CEV	competence damage-inducible protein
D1869_07955	ENOG4105F2Z	3-oxoadipate enol-lactonase
D1869_07970	ENOG4105E8R	UPF0173 metal-dependent hydrolase
D1869_08000	ENOG4108KP7	hydrolase
D1869_08005	ENOG4105CX6	glutaminyL-tRNA synthetase
D1869_08025	ENOG4105CQ2	DNA polymerase
D1869_08055	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
D1869_08075	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
D1869_08080	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
D1869_08085	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
D1869_08100	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
D1869_08110	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
D1869_08115	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
D1869_08130	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
D1869_08140	ENOG4105C7K	acetolactate synthase
D1869_08150	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
D1869_08175	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
D1869_08185	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
D1869_08195	ENOG4105C8T	Leucyl-tRNA synthetase
D1869_08205	ENOG4105CIH	Imidazole acetol-phosphate transaminase
D1869_08210	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
D1869_08215	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
D1869_08220	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
D1869_08225	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
D1869_08230	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
D1869_08235	ENOG41083RF	phosphoribosyl-ATP pyrophosphatase
D1869_08240	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
D1869_08245	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
D1869_08250	ENOG4105VG1	fes assembly suf system protein
D1869_08255	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
D1869_08260	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
D1869_08270	ENOG4105K59	histidine triad (HIT) protein
D1869_08280	ENOG4108VVK	transcriptional Regulator, AsnC
D1869_08300	ENOG4105CS7	Catalyzes the conversion of dihydroorotate to orotate
D1869_08305	ENOG4105CD3	dihydroorotase
D1869_08315	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
D1869_08325	ENOG4107XPQ	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
D1869_08370	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
D1869_08380	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
D1869_08385	ENOG4105C8V	SAICAR synthetase
D1869_08395	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
D1869_08400	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
D1869_08415	ENOG4105C12	Phosphoribosylglycinamide synthetase
D1869_08420	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
D1869_08435	ENOG4105CDH	Citrulline--aspartate ligase
D1869_08440	ENOG4105CH7	arginosuccinase
D1869_08445	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
D1869_08455	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
D1869_08465	ENOG4105F35	Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity)
D1869_08510	ENOG4105E39	Enoyl-CoA hydratase
D1869_08520	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
D1869_08540	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
D1869_08550	ENOG4107YZX	Universal stress protein
D1869_08560	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
D1869_08565	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D1869_08595	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
D1869_08600	ENOG4105DDK	oxidoreductase, beta subunit
D1869_08620	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
D1869_08665	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
D1869_08670	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
D1869_08675	ENOG4105C9X	ppx gppa phosphatase
D1869_08685	ENOG4105D0M	Protease HtpX homolog
D1869_08695	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
D1869_08750	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
D1869_08755	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
D1869_08795	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
D1869_08875	ENOG4105CJ1	ABC, transporter
D1869_08910	ENOG4105E8R	UPF0173 metal-dependent hydrolase
D1869_09055	ENOG4105EN6	Membrane
D1869_09085	ENOG4105CB5	ATP-dependent DNA helicase recG
D1869_09125	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
D1869_09145	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
D1869_09175	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
D1869_09235	ENOG4105CPP	Dehydrogenase, E1 component
D1869_09240	ENOG4107RUY	(E1 component), alpha subunit
D1869_09290	ENOG4108JJB	ABC transporter
D1869_09295	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
D1869_09305	ENOG4105CTD	carboxy-peptidase
D1869_09330	ENOG4107QR9	Iron-sulfur cluster binding protein
D1869_09390	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
D1869_09395	ENOG4105PEJ	SchA CurD domain protein
D1869_09410	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
D1869_09450	ENOG4105EYF	MMPL domain protein
D1869_09460	ENOG4105CQ2	DNA polymerase
D1869_09505	ENOG4105CSH	Transporter
D1869_09580	ENOG4105ERH	Fumarylacetoacetate hydrolase
D1869_09585	ENOG4108JJB	ABC transporter
D1869_09600	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
D1869_09605	ENOG4108T3F	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
D1869_09610	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
D1869_09725	ENOG4105CJ1	ABC, transporter
D1869_09750	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
D1869_09885	ENOG4107QTZ	amino acid
D1869_10055	ENOG4105CJ1	ABC, transporter
D1869_10075	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
D1869_10080	ENOG4105C10	Electron transfer flavoprotein
D1869_10100	ENOG4105KHC	sulfurtransferase
D1869_10105	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1869_10115	ENOG4105DDK	oxidoreductase, beta subunit
D1869_10120	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
D1869_10150	ENOG4105C1G	acyl-Coa dehydrogenase
D1869_10155	ENOG4105BZJ	Electron transfer flavoprotein
D1869_10165	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
D1869_10175	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
D1869_10200	ENOG4105C1G	acyl-Coa dehydrogenase
D1869_10205	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
D1869_10215	ENOG4105BZN	citrate synthase
D1869_10220	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
D1869_10225	ENOG4105CR4	methylisocitrate lyase
D1869_10230	ENOG4105DXD	2-methylcitrate dehydratase
D1869_10235	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
D1869_10250	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
D1869_10270	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
D1869_10280	ENOG4107XSI	cobalt-precorrin-6y C15-methyltransferase
D1869_10290	ENOG4105E4R	Precorrin-3B C17-methyltransferase
D1869_10295	ENOG41081F0	Precorrin-8x methylmutase
D1869_10300	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
D1869_10310	ENOG4105D44	asparaginase
D1869_10325	ENOG4105EHU	Circadian clock protein KaiC
D1869_10355	ENOG4105WCA	Ferredoxin
D1869_10365	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
D1869_10370	ENOG4105DB1	molybdopterin oxidoreductase
D1869_10400	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
D1869_10445	ENOG4105FCD	Major Facilitator
D1869_10485	ENOG4107RWR	Sodium hydrogen exchanger
D1869_10500	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
D1869_10525	ENOG4105CHR	reductase
D1869_10555	ENOG4105EWK	phytoene
D1869_10570	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
D1869_10575	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
D1869_10630	ENOG4105DF9	Lipoate-protein, ligase
D1869_10655	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
D1869_10665	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
D1869_10670	ENOG4108UR0	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
D1869_10675	ENOG4105DF9	Lipoate-protein, ligase
D1869_10700	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
D1869_10720	ENOG4105D5M	phosphate starvation-inducible protein
D1869_10725	ENOG4105CGK	Exodeoxyribonuclease III
D1869_10735	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
D1869_10745	ENOG4105EYF	MMPL domain protein
D1869_10755	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
D1869_10840	ENOG4105DCI	Phosphohydrolase
D1869_10920	ENOG4105CPK	Glycosyl transferase (Group 1
D1869_10990	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
D1869_11095	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
D1869_11110	ENOG4105C5X	domain protein
D1869_11115	ENOG4105C9Q	fumarate hydratase class II
D1869_11145	ENOG4105CP7	Triose-phosphate isomerase
D1869_11155	ENOG4105E0C	molybdate abc transporter
D1869_11180	ENOG4107R5H	iron (metal) dependent repressor, dtxr family
D1869_11200	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
D1869_11215	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
D1869_11220	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
D1869_11235	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
D1869_11285	ENOG4107QPD	alcohol dehydrogenase
D1869_11290	ENOG4105ESV	Glycosyl transferase, family 4
D1869_11300	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
D1869_11310	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
D1869_11315	ENOG4105CE9	30S ribosomal protein S2
D1869_11325	ENOG4108UJD	30S ribosomal protein S9
D1869_11330	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
D1869_11335	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
D1869_11345	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
D1869_11350	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
D1869_11355	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1869_11375	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
D1869_11385	ENOG4105CQ2	DNA polymerase
D1869_11420	ENOG4105CRK	lysyL-tRNA synthetase
D1869_11455	ENOG4105DG4	malate L-lactate dehydrogenase
D1869_11475	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
D1869_11480	ENOG4105DZS	Phenylacetate-CoA ligase
D1869_11515	ENOG4106HB6	Alpha beta hydrolase
D1869_11525	ENOG4108MYP	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
D1869_11530	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1869_11535	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
D1869_11560	ENOG4107WZZ	SMC domain protein
D1869_11560	ENOG4107WZZ	SMC domain protein
D1869_11615	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
D1869_11635	ENOG4105K63	Thioredoxin
D1869_11690	ENOG4105CAY	ferredoxin--nadp reductase
D1869_11700	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
D1869_11715	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
D1869_11730	ENOG4108K7V	UPF0284 protein
D1869_11740	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
D1869_11745	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
D1869_11750	ENOG4105J7I	hydrolase
D1869_11765	ENOG4105K59	histidine triad (HIT) protein
D1869_11775	ENOG4107VIJ	nudix hydrolase
D1869_11790	ENOG4105Q33	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency
D1869_11800	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
D1869_11805	ENOG4105C4K	Nad synthetase
D1869_11850	ENOG4108HMX	isocitrate dehydrogenase (NADP)
D1869_11875	ENOG4107QK3	aspartate-semialdehyde dehydrogenase (EC 1.2.1.11
D1869_11880	ENOG4105C01	Dihydroxy-acid dehydratase
D1869_11895	ENOG41088CC	tellurite resistance protein tehB
D1869_11920	ENOG4108WBT	adenosyltransferase
D1869_11925	ENOG4107Y9U	Membrane
D1869_11930	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
D1869_11940	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
D1869_11945	ENOG4105C22	threonyL-tRNA synthetase
D1869_11950	ENOG4105CY0	Metallo-Beta-Lactamase
D1869_12070	ENOG4105CBC	glutamate synthase
D1869_12075	ENOG4105EYU	Glutamine amido-transferase
D1869_12115	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
D1869_12120	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
D1869_12180	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
D1869_12190	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D1869_12195	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D1869_12200	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
D1869_12205	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D1869_12215	ENOG41082X4	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D1869_12220	ENOG4105D65	subunit l
D1869_12225	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D1869_12230	ENOG4105CZA	synthase
D1869_12235	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
D1869_12285	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
D1869_12295	ENOG4108VCT	Sulfite exporter TauE/SafE
D1869_12305	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
D1869_12310	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
D1869_12315	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
D1869_12325	ENOG4105D82	Glutamate dehydrogenase
D1869_12340	ENOG4105C8N	cysteinyl-tRNA synthetase
D1869_12345	ENOG41086CI	Bifunctional phosphoglucose phosphomannose isomerase
D1869_12355	ENOG4107SJS	nitrite reductase, (NAD(P)H)
D1869_12375	ENOG4108S4H	thioesterase Superfamily protein
D1869_12380	ENOG4105CPQ	Dehydrogenase
D1869_12400	ENOG4105C1G	acyl-Coa dehydrogenase
D1869_12470	ENOG4105D06	uba thif-type nad fad binding protein
D1869_12475	ENOG4108HHA	Transketolase
D1869_12480	ENOG4108IUS	Transketolase
D1869_12490	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
D1869_12495	ENOG4105D49	3-dehydroquinate synthase
D1869_12500	ENOG4105E2X	shikimate dehydrogenase
D1869_12505	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
D1869_12510	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
D1869_12515	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
D1869_12535	ENOG4105DVT	helicase
D1869_12560	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
D1869_12575	ENOG4105C7Z	Conserved Protein
D1869_12595	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
D1869_12615	ENOG4107QJE	Chromosome Partitioning Protein
D1869_12625	ENOG4105CQB	FAD linked oxidase domain protein
D1869_12640	ENOG4105DQU	oxidoreductase, subunit beta
D1869_12645	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
D1869_12665	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
D1869_12670	ENOG4105DGU	Histone deacetylase
D1869_12675	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
D1869_12710	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
D1869_12720	ENOG4107QRT	dEAD DEAH box helicase
D1869_12725	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
D1869_12760	ENOG4105DC7	peptidase M24
D1869_12780	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
D1869_12785	ENOG4108RVA	ribokinase
D1869_12790	ENOG4105DWF	phosphomethylpyrimidine kinase
D1869_12800	ENOG4105CND	Glycosyl transferase, family 2
D1869_12805	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
D1869_12810	ENOG4105CIF	Ornithine Cyclodeaminase
D1869_12820	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
D1869_12840	ENOG4105CPQ	Dehydrogenase
D1869_12845	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
D1869_12860	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
D1869_12865	ENOG4105D0M	Protease HtpX homolog
D1869_12880	ENOG41061GT	Aldolase
D1869_12905	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
D1869_12920	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
D1869_12950	ENOG4105C54	Major Facilitator superfamily
D1869_12970	ENOG4105MEW	serine threonine protein phosphatase
D1869_12990	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
D1869_13060	ENOG4105D1H	recombination factor protein RarA
D1869_13075	ENOG4105JNK	Glycosyl transferase (Group 1
D1869_13085	ENOG4105RV9	Transcriptional regulator
D1869_13155	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
D1869_13170	ENOG4105DZC	cytosine deaminase
D1869_13175	ENOG4105EUB	pirin domain protein
D1869_13180	ENOG4105E50	uracil-dna glycosylase
D1869_13205	ENOG4105C7K	acetolactate synthase
D1869_13215	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
D1869_13220	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
D1869_13240	ENOG4105CGU	Enoyl-CoA hydratase
D1869_13245	ENOG4105CHU	acetyl-coa acetyltransferase
D1869_13255	ENOG4105DZS	Phenylacetate-CoA ligase
D1869_13270	ENOG4105JHE	Major Facilitator Superfamily
D1869_13275	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
D1869_13300	ENOG4105C54	Major Facilitator superfamily
D1869_13320	ENOG4106JUT	Streptomycin 3''-adenylyltransferase
D1869_13330	ENOG4105DQU	oxidoreductase, subunit beta
D1869_13335	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
D1869_13340	ENOG4105CIG	ABC transporter
D1869_13355	ENOG4105D9P	serine threonine protein kinase
D1869_13365	ENOG4105CEU	Arginine dihydrolase
D1869_13370	ENOG4105D3R	alkyl hydroperoxide reductase
D1869_13395	ENOG4108R96	Methyltransferase, YaeB family
D1869_13405	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
D1869_13470	ENOG4105C1J	atp-dependent rna helicase
D1869_13505	ENOG4105FEU	K -dependent Na -Ca exchanger
D1869_13510	ENOG4105VG5	Membrane
D1869_13515	ENOG4105EM7	Selenocysteine-specific translation elongation factor
D1869_13555	ENOG4107QTZ	amino acid
D1869_13560	ENOG4105C26	Dehydrogenase
D1869_13565	ENOG4105EDK	PfkB domain protein
D1869_13570	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
D1869_13590	ENOG4105CEP	NADH dehydrogenase
D1869_13600	ENOG4105CV8	reductase
D1869_13640	ENOG4107ZTW	SNARE associated Golgi
D1869_13660	ENOG4105D3W	isochorismatase
D1869_13665	ENOG4105CIG	ABC transporter
D1869_13675	ENOG4105CDZ	Carboxymethylenebutenolidase (EC 3.1.1.45)
D1869_13725	ENOG4105C3U	ABC transporter
D1869_13730	ENOG4108JQ7	(ABC) transporter
D1869_13755	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
D1869_13760	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
D1869_13765	ENOG4105C3U	ABC transporter
D1869_13770	ENOG4108JQ7	(ABC) transporter
D1869_13780	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
D1869_13785	ENOG4105CE4	GlcNAc 6-P deacetylase
D1869_13820	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
D1869_13825	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
D1869_13860	ENOG4105DRR	Transcriptional regulator, GntR family
D1869_13870	ENOG4105E4P	ATPase (AAA
D1869_13875	ENOG4105CXK	mandelate racemase muconate lactonizing
D1869_13880	ENOG4107QN2	dihydrolipoyl dehydrogenase
D1869_13945	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
D1869_14000	ENOG4105BZ9	Cytochrome C oxidase, subunit I
D1869_14030	ENOG4105PEJ	SchA CurD domain protein
D1869_14040	ENOG4105C6X	Major Facilitator
D1869_14050	ENOG4105EE1	crotonyl-CoA reductase
D1869_14140	ENOG4108IUE	nitrate reductase beta subunit
D1869_14150	ENOG4105DQQ	Major facilitator superfamily MFS_1
D1869_14200	ENOG4108JJB	ABC transporter
D1869_14230	ENOG4105CSH	Transporter
D1869_14445	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
D1869_14470	ENOG4105CUG	Oligopeptidase b
D1869_14475	ENOG4106PBJ	Serine threonine-protein kinase Pkn6
D1869_14480	ENOG4105CIG	ABC transporter
D1869_14675	ENOG4105E39	Enoyl-CoA hydratase
D1869_14690	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
D1869_14700	ENOG4105CSH	Transporter
D1869_14730	ENOG4105CEY	Amp-dependent synthetase and ligase
D1869_14740	ENOG4105C26	Dehydrogenase
D1869_14765	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
D1869_14770	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
D1869_14790	ENOG4105CPQ	Dehydrogenase
D1869_14795	ENOG4105C1G	acyl-Coa dehydrogenase
D1869_14800	ENOG4105CEY	Amp-dependent synthetase and ligase
D1869_14805	ENOG4105CHU	acetyl-coa acetyltransferase
D1869_14815	ENOG4108IEG	Formate dehydrogenase Alpha subunit
D1869_14825	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
D1869_14830	ENOG4105D2B	acyl-CoA dehydrogenase
D1869_14835	ENOG4108Z7G	MaoC domain protein dehydratase
D1869_14840	ENOG4105CC9	acyl-Coa dehydrogenase
D1869_14865	ENOG4105C54	Major Facilitator superfamily
D1869_14875	ENOG4105C7W	Xanthine dehydrogenase
D1869_14885	ENOG4106YT9	Enoyl-CoA hydratase
D1869_14890	ENOG4105CHU	acetyl-coa acetyltransferase
D1869_14905	ENOG4105D82	Glutamate dehydrogenase
D1869_14920	ENOG4105BZ9	Cytochrome C oxidase, subunit I
D1869_14950	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
D1869_14965	ENOG4107WJM	-acetyltransferase
D1869_14970	ENOG4105C6K	Malic enzyme
D1869_14980	ENOG4105K4P	CoA-binding domain protein
D1869_15030	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
D1869_15035	ENOG4105CV8	reductase
D1869_15070	ENOG4105BZ9	Cytochrome C oxidase, subunit I
D1869_15075	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)