locus-tag	class	description
D1869_00020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1869_00195	COG1131	(ABC) transporter
D1869_00305	COG1280	lysine exporter protein (LysE YggA)
D1869_00325	COG0489	protein tyrosine kinase activity
D1869_00365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1869_00370	COG0730	response to heat
D1869_00390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1869_00415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1869_00420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1869_00425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1869_00430	COG0189	ligase activity
D1869_00445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1869_00450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1869_00465	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1869_00505	COG0028	Belongs to the TPP enzyme family
D1869_00530	COG0017	Asparaginyl-tRNA synthetase
D1869_00535	COG0585	pseudouridine synthase activity
D1869_00555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1869_00570	COG1648	precorrin-2 dehydrogenase activity
D1869_00570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1869_00575	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D1869_00580	COG0113	porphobilinogen synthase activity
D1869_00585	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1869_00590	COG0181	hydroxymethylbilane synthase activity
D1869_00615	COG2022	thiamine diphosphate biosynthetic process
D1869_00615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1869_00625	COG1793	dna ligase
D1869_00645	COG2078	PFAM AMMECR1 domain protein
D1869_00675	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
D1869_00690	COG0504	CTP synthase activity
D1869_00695	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D1869_00715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1869_00725	COG3830	Belongs to the UPF0237 family
D1869_00785	COG0456	acetyltransferase
D1869_00855	COG0051	transcription antitermination factor activity, RNA binding
D1869_00860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1869_00885	COG1358	cellular component organization or biogenesis
D1869_00890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1869_00895	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1869_00900	COG0085	RNA polymerase activity
D1869_00910	COG0281	malic enzyme
D1869_00915	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D1869_00920	COG0105	UTP biosynthetic process
D1869_00935	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1869_00940	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1869_00945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1869_00960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1869_00965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1869_00980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1869_00995	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1869_01000	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D1869_01010	COG0077	Prephenate dehydratase
D1869_01015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1869_01035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1869_01035	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
D1869_01050	COG1056	cytidyltransferase-related domain
D1869_01050	COG1051	belongs to the nudix hydrolase family
D1869_01055	COG1607	acyl-coa hydrolase
D1869_01095	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
D1869_01180	COG1121	(ABC) transporter
D1869_01185	COG1980	fructose-bisphosphate aldolase activity
D1869_01210	COG0459	protein refolding
D1869_01225	COG0124	histidyl-tRNA synthetase
D1869_01245	COG0343	queuine tRNA-ribosyltransferase activity
D1869_01260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1869_01270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1869_01300	COG0477	Major facilitator Superfamily
D1869_01310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D1869_01335	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D1869_01345	COG1047	Peptidyl-prolyl cis-trans
D1869_01355	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D1869_01410	COG4152	abc transporter atp-binding protein
D1869_01435	COG1136	(ABC) transporter
D1869_01435	COG0577	efflux transmembrane transporter activity
D1869_01440	COG1136	(ABC) transporter
D1869_01445	COG3383	formate dehydrogenase (NAD+) activity
D1869_01470	COG0023	Translation Initiation Factor
D1869_01485	COG0423	glycine-tRNA ligase activity
D1869_01515	COG0163	prenyltransferase activity
D1869_01525	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
D1869_01540	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1869_01550	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1869_01555	COG0667	Aldo Keto reductase
D1869_01600	COG1110	DNA topoisomerase II activity
D1869_01605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1869_01610	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
D1869_01655	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1869_01660	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1869_01690	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D1869_01720	COG1201	RNA secondary structure unwinding
D1869_01735	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1869_01740	COG2813	Specifically methylates the guanine in position
D1869_01750	COG0438	transferase activity, transferring glycosyl groups
D1869_01795	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1869_01820	COG0200	Binds to the 23S rRNA
D1869_01830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1869_01850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1869_01855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1869_01865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1869_01880	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D1869_01895	COG0255	Belongs to the universal ribosomal protein uL29 family
D1869_01900	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1869_01905	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1869_01910	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1869_01915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1869_01920	COG0089	rRNA binding
D1869_01925	COG0088	Forms part of the polypeptide exit tunnel
D1869_01945	COG0473	3-isopropylmalate dehydrogenase activity
D1869_01965	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1869_01970	COG0492	ferredoxin-NADP+ reductase activity
D1869_01975	COG0322	excinuclease ABC activity
D1869_02005	COG1185	polyribonucleotide nucleotidyltransferase activity
D1869_02045	COG0012	GTP binding
D1869_02050	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D1869_02060	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D1869_02065	COG2264	protein methyltransferase activity
D1869_02070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1869_02120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1869_02180	COG0315	cyclic pyranopterin monophosphate synthase activity
D1869_02185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1869_02190	COG2255	four-way junction helicase activity
D1869_02195	COG1881	PFAM PEBP family protein
D1869_02200	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D1869_02205	COG0154	amidase activity
D1869_02215	COG1063	alcohol dehydrogenase
D1869_02240	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D1869_02245	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D1869_02255	COG0142	geranyltranstransferase activity
D1869_02260	COG0189	ligase activity
D1869_02265	COG1522	sequence-specific DNA binding
D1869_02295	COG0644	oxidoreductase
D1869_02315	COG1053	succinate dehydrogenase
D1869_02325	COG2048	Heterodisulfide reductase, subunit B
D1869_02335	COG2304	oxidoreductase activity
D1869_02340	COG0714	Associated with various cellular activities
D1869_02355	COG0303	'Molybdopterin
D1869_02360	COG0083	homoserine kinase activity
D1869_02365	COG0626	cystathionine gamma-synthase activity
D1869_02405	COG0183	Belongs to the thiolase family
D1869_02410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1869_02470	COG0314	molybdopterin synthase activity
D1869_02535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1869_02590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1869_02605	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D1869_02620	COG0071	Belongs to the small heat shock protein (HSP20) family
D1869_02645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1869_02665	COG1648	precorrin-2 dehydrogenase activity
D1869_02665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1869_02710	COG0430	RNA-3'-phosphate cyclase activity
D1869_02720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1869_02725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1869_02730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1869_02735	COG1051	belongs to the nudix hydrolase family
D1869_02740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1869_02740	COG0519	Catalyzes the synthesis of GMP from XMP
D1869_02745	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D1869_02755	COG1515	deoxyribonuclease V activity
D1869_02760	COG1335	isochorismatase
D1869_02770	COG0450	alkyl hydroperoxide reductase
D1869_02785	COG0372	Belongs to the citrate synthase family
D1869_02805	COG4581	dead DEAH box helicase
D1869_02815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1869_02825	COG0439	Biotin carboxylase
D1869_02835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1869_02835	COG1116	anion transmembrane transporter activity
D1869_02840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1869_02850	COG0805	protein transport
D1869_02855	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D1869_02860	COG0066	3-isopropylmalate dehydratase activity
D1869_02865	COG0778	Nitroreductase
D1869_02895	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D1869_02920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1869_02995	COG0495	leucyl-tRNA aminoacylation
D1869_03005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1869_03025	COG0037	tRNA processing
D1869_03035	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1869_03065	COG0475	glutathione-regulated potassium exporter activity
D1869_03070	COG3383	formate dehydrogenase (NAD+) activity
D1869_03105	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1869_03115	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D1869_03120	COG0277	FAD linked oxidase domain protein
D1869_03130	COG1252	NADH dehydrogenase
D1869_03180	COG0004	ammonium transporteR
D1869_03220	COG0584	glycerophosphoryl diester phosphodiesterase
D1869_03260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1869_03290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1869_03310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1869_03390	COG0574	Belongs to the PEP-utilizing enzyme family
D1869_03390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1869_03405	COG4608	Belongs to the ABC transporter superfamily
D1869_03410	COG0444	Belongs to the ABC transporter superfamily
D1869_03415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1869_03470	COG2002	toxin-antitoxin pair type II binding
D1869_03525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1869_03535	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1869_03545	COG2368	4-hydroxyphenylacetate
D1869_03555	COG0475	glutathione-regulated potassium exporter activity
D1869_03560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1869_03565	COG1584	GPR1 FUN34 yaaH family protein
D1869_03570	COG4274	PFAM GYD family protein
D1869_03585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1869_03620	COG2151	metal-sulfur cluster biosynthetic enzyme
D1869_03675	COG0028	Belongs to the TPP enzyme family
D1869_03680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1869_03705	COG4555	ABC transporter
D1869_03775	COG0455	bacterial-type flagellum organization
D1869_03785	COG0517	IMP dehydrogenase activity
D1869_03810	COG2226	methyltransferase
D1869_03825	COG0515	serine threonine protein kinase
D1869_03830	COG4946	Tricorn protease homolog
D1869_03830	COG1506	peptidase
D1869_03830	COG0823	Involved in the tonB-independent uptake of proteins
D1869_03850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1869_03895	COG1121	(ABC) transporter
D1869_03925	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D1869_03970	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D1869_03975	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D1869_03990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1869_03995	COG0297	glycogen (starch) synthase activity
D1869_04005	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1869_04020	COG0516	GMP reductase activity
D1869_04020	COG0517	IMP dehydrogenase activity
D1869_04055	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D1869_04060	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D1869_04145	COG1131	(ABC) transporter
D1869_04260	COG2124	cytochrome p450
D1869_04295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1869_04340	COG1201	RNA secondary structure unwinding
D1869_04380	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1869_04395	COG1136	(ABC) transporter
D1869_04395	COG0577	efflux transmembrane transporter activity
D1869_04405	COG1136	(ABC) transporter
D1869_04455	COG2814	Major facilitator Superfamily
D1869_04485	COG0693	protein deglycase activity
D1869_04490	COG0415	Belongs to the DNA photolyase family
D1869_04535	COG0425	Belongs to the sulfur carrier protein TusA family
D1869_04595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1869_04705	COG0531	amino acid
D1869_04785	COG1121	(ABC) transporter
D1869_04790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1869_04825	COG0501	Belongs to the peptidase M48B family
D1869_05075	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1869_05095	COG3387	PFAM Glycoside hydrolase 15-related
D1869_05100	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1869_05115	COG2264	protein methyltransferase activity
D1869_05175	COG2814	Major facilitator Superfamily
D1869_05180	COG1028	Short-chain dehydrogenase reductase Sdr
D1869_05200	COG0318	PFAM AMP-dependent synthetase and ligase
D1869_05205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1869_05245	COG4948	Mandelate Racemase Muconate Lactonizing
D1869_05255	COG3842	ATPase activity
D1869_05260	COG3833	ABC-type maltose transport systems, permease component
D1869_05265	COG1175	transmembrane transport
D1869_05325	COG0697	spore germination
D1869_05350	COG0393	Putative heavy-metal-binding
D1869_05430	COG1121	(ABC) transporter
D1869_05475	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D1869_05490	COG1489	DNA binding
D1869_05515	COG0455	bacterial-type flagellum organization
D1869_05625	COG1733	regulation of RNA biosynthetic process
D1869_05650	COG0298	carbon dioxide binding
D1869_05675	COG0298	carbon dioxide binding
D1869_05685	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D1869_05695	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
D1869_05720	COG3511	phospholipase C
D1869_05730	COG1122	ATPase activity
D1869_05765	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D1869_05790	COG4133	protoheme IX ABC transporter activity
D1869_05830	COG2235	arginine
D1869_05840	COG1017	nitric oxide dioxygenase activity
D1869_05850	COG2223	nitrite transmembrane transporter activity
D1869_05855	COG0243	molybdopterin cofactor binding
D1869_05860	COG0243	molybdopterin cofactor binding
D1869_05870	COG0831	urea catabolic process
D1869_05870	COG0832	Belongs to the urease beta subunit family
D1869_05875	COG0804	urea catabolic process
D1869_05890	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D1869_05900	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
D1869_05905	COG1522	sequence-specific DNA binding
D1869_05940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1869_05950	COG0174	glutamine synthetase
D1869_05985	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
D1869_06035	COG0402	S-adenosylhomocysteine deaminase activity
D1869_06070	COG1131	(ABC) transporter
D1869_06085	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1869_06095	COG0383	alpha-mannosidase activity
D1869_06100	COG0352	thiamine-phosphate diphosphorylase activity
D1869_06100	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D1869_06100	COG0351	phosphomethylpyrimidine kinase
D1869_06105	COG0477	Major facilitator Superfamily
D1869_06130	COG2017	converts alpha-aldose to the beta-anomer
D1869_06175	COG0454	-acetyltransferase
D1869_06200	COG1373	ATPase (AAA superfamily
D1869_06285	COG1078	dGTPase activity
D1869_06290	COG0813	purine-nucleoside phosphorylase activity
D1869_06300	COG0438	transferase activity, transferring glycosyl groups
D1869_06305	COG3387	PFAM Glycoside hydrolase 15-related
D1869_06315	COG1252	NADH dehydrogenase
D1869_06395	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1869_06405	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1869_06420	COG0045	succinate-CoA ligase (ADP-forming) activity
D1869_06465	COG0243	molybdopterin cofactor binding
D1869_06495	COG0409	Hydrogenase expression formation protein
D1869_06555	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D1869_06580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1869_06615	COG1185	polyribonucleotide nucleotidyltransferase activity
D1869_06645	COG0084	hydrolase, TatD family'
D1869_06655	COG2814	Major facilitator Superfamily
D1869_06710	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D1869_06720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1869_06730	COG1960	acyl-CoA dehydrogenase activity
D1869_06755	COG2814	Major facilitator Superfamily
D1869_06770	COG4946	Tricorn protease homolog
D1869_06770	COG0793	Belongs to the peptidase S41A family
D1869_06790	COG2271	Major facilitator Superfamily
D1869_06855	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
D1869_06930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1869_06965	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D1869_06970	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D1869_06975	COG0157	Belongs to the NadC ModD family
D1869_06995	COG0719	Fe-S assembly protein
D1869_07000	COG0396	ATPase activity
D1869_07020	COG0509	glycine decarboxylation via glycine cleavage system
D1869_07025	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1869_07030	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1869_07035	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1869_07075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1869_07080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1869_07095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1869_07100	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
D1869_07130	COG0525	valine-tRNA ligase activity
D1869_07145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1869_07145	COG0512	Glutamine amidotransferase of anthranilate synthase
D1869_07150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1869_07155	COG0135	phosphoribosylanthranilate isomerase activity
D1869_07160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1869_07165	COG0159	tryptophan synthase activity
D1869_07170	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
D1869_07175	COG1254	Belongs to the acylphosphatase family
D1869_07190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1869_07190	COG0574	Belongs to the PEP-utilizing enzyme family
D1869_07215	COG0527	aspartate kinase activity
D1869_07215	COG0460	homoserine dehydrogenase
D1869_07225	COG0587	DNA-directed DNA polymerase activity
D1869_07235	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D1869_07270	COG0459	protein refolding
D1869_07305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1869_07320	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1869_07325	COG0252	asparaginase activity
D1869_07355	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
D1869_07405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D1869_07405	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D1869_07420	COG0154	amidase activity
D1869_07425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1869_07430	COG1324	tolerance protein
D1869_07465	COG1110	DNA topoisomerase II activity
D1869_07475	COG1201	RNA secondary structure unwinding
D1869_07505	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1869_07510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1869_07520	COG1028	Short-chain dehydrogenase reductase Sdr
D1869_07540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1869_07555	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D1869_07595	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D1869_07620	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1869_07625	COG0589	response to stress
D1869_07635	COG0126	phosphoglycerate kinase activity
D1869_07680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1869_07690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1869_07700	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1869_07715	COG0552	protein localization to endoplasmic reticulum
D1869_07795	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1869_07800	COG0006	proline dipeptidase activity
D1869_07805	COG0302	gtp cyclohydrolase
D1869_07825	COG0318	PFAM AMP-dependent synthetase and ligase
D1869_07840	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D1869_07870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D1869_07895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D1869_07910	COG1201	RNA secondary structure unwinding
D1869_07945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1869_07955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1869_07970	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1869_07975	COG0024	Methionine aminopeptidase
D1869_08000	COG0561	phosphatase activity
D1869_08005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1869_08025	COG0417	DNA replication proofreading
D1869_08055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1869_08075	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
D1869_08080	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
D1869_08085	COG1394	ATPase activity, coupled to movement of substances
D1869_08110	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D1869_08115	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D1869_08130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1869_08140	COG0028	Belongs to the TPP enzyme family
D1869_08150	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D1869_08175	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D1869_08185	COG0037	tRNA processing
D1869_08195	COG0495	leucyl-tRNA aminoacylation
D1869_08205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1869_08210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D1869_08215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D1869_08220	COG0131	Imidazoleglycerol-phosphate dehydratase
D1869_08225	COG0107	imidazoleglycerol-phosphate synthase activity
D1869_08230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1869_08235	COG0140	phosphoribosyl-ATP diphosphatase activity
D1869_08240	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D1869_08245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D1869_08250	COG2151	metal-sulfur cluster biosynthetic enzyme
D1869_08255	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D1869_08260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1869_08270	COG0537	adenosine 5'-monophosphoramidase activity
D1869_08280	COG1522	sequence-specific DNA binding
D1869_08300	COG0167	dihydroorotate dehydrogenase activity
D1869_08305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1869_08315	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
D1869_08325	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1869_08330	COG0284	orotidine-5'-phosphate decarboxylase activity
D1869_08370	COG0602	queuosine metabolic process
D1869_08380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1869_08380	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1869_08385	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D1869_08395	COG0047	phosphoribosylformylglycinamidine synthase activity
D1869_08400	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1869_08405	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1869_08410	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1869_08415	COG0151	Belongs to the GarS family
D1869_08420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1869_08435	COG0137	argininosuccinate synthase activity
D1869_08445	COG0505	Belongs to the CarA family
D1869_08455	COG0189	ligase activity
D1869_08465	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1869_08510	COG1024	Enoyl-CoA hydratase
D1869_08520	COG1612	heme a metabolic process
D1869_08520	COG0109	protoheme IX farnesyltransferase activity
D1869_08525	COG0460	homoserine dehydrogenase
D1869_08540	COG0312	modulator of DNA gyrase
D1869_08550	COG0589	response to stress
D1869_08560	COG0009	L-threonylcarbamoyladenylate synthase
D1869_08565	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1869_08595	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1869_08600	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1869_08620	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1869_08665	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1869_08670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1869_08680	COG2062	phosphohistidine phosphatase, SixA
D1869_08695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1869_08795	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
D1869_08875	COG1131	(ABC) transporter
D1869_08910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1869_09055	COG2860	membrane
D1869_09085	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1869_09125	COG2226	methyltransferase
D1869_09145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1869_09235	COG0022	dehydrogenase e1 component
D1869_09240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D1869_09295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1869_09300	COG0601	transmembrane transport
D1869_09305	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D1869_09315	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1869_09330	COG1139	Iron-sulfur cluster binding protein
D1869_09390	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1869_09395	COG2329	Antibiotic biosynthesis monooxygenase
D1869_09460	COG0417	DNA replication proofreading
D1869_09505	COG0477	Major facilitator Superfamily
D1869_09580	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1869_09585	COG4172	Belongs to the ABC transporter superfamily
D1869_09605	COG1846	Transcriptional regulator
D1869_09610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1869_09725	COG1131	(ABC) transporter
D1869_09750	COG4946	Tricorn protease homolog
D1869_09750	COG1506	peptidase
D1869_09750	COG0823	Involved in the tonB-independent uptake of proteins
D1869_09885	COG0531	amino acid
D1869_10055	COG1131	(ABC) transporter
D1869_10075	COG0644	oxidoreductase
D1869_10080	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D1869_10100	COG2897	thiosulfate sulfurtransferase activity
D1869_10105	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1869_10115	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1869_10120	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1869_10150	COG1960	acyl-CoA dehydrogenase activity
D1869_10155	COG2086	electron transfer activity
D1869_10165	COG0644	oxidoreductase
D1869_10200	COG1960	acyl-CoA dehydrogenase activity
D1869_10205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1869_10215	COG0372	Belongs to the citrate synthase family
D1869_10220	COG0517	IMP dehydrogenase activity
D1869_10220	COG0516	GMP reductase activity
D1869_10225	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D1869_10230	COG2079	MmgE PrpD family protein
D1869_10235	COG0039	L-malate dehydrogenase activity
D1869_10250	COG1968	undecaprenyl-diphosphatase activity
D1869_10310	COG1446	asparaginase
D1869_10325	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D1869_10355	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
D1869_10365	COG0437	4 iron, 4 sulfur cluster binding
D1869_10370	COG0243	molybdopterin cofactor binding
D1869_10400	COG3386	PFAM SMP-30 Gluconolaconase
D1869_10485	COG0475	glutathione-regulated potassium exporter activity
D1869_10500	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D1869_10505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1869_10570	COG0425	Belongs to the sulfur carrier protein TusA family
D1869_10575	COG2210	Belongs to the sulfur carrier protein TusA family
D1869_10630	COG0095	Lipoate-protein ligase
D1869_10655	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D1869_10665	COG0509	glycine decarboxylation via glycine cleavage system
D1869_10670	COG0509	glycine decarboxylation via glycine cleavage system
D1869_10675	COG0095	Lipoate-protein ligase
D1869_10700	COG1914	H( )-stimulated, divalent metal cation uptake system
D1869_10720	COG1702	phosphate starvation-inducible protein PhoH
D1869_10725	COG0708	Exodeoxyribonuclease III
D1869_10735	COG1444	tRNA N-acetyltransferase activity
D1869_10760	COG1175	transmembrane transport
D1869_10840	COG1078	dGTPase activity
D1869_10850	COG0463	Glycosyl transferase, family 2
D1869_10855	COG0275	rRNA processing
D1869_10870	COG2192	nodulation
D1869_10920	COG0438	transferase activity, transferring glycosyl groups
D1869_10990	COG2890	protein-(glutamine-N5) methyltransferase activity
D1869_11095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1869_11110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1869_11115	COG0114	fumarate hydratase activity
D1869_11145	COG0149	triose-phosphate isomerase activity
D1869_11180	COG1321	iron dependent repressor
D1869_11200	COG2226	methyltransferase
D1869_11215	COG0303	'Molybdopterin
D1869_11220	COG0746	molybdenum cofactor guanylyltransferase activity
D1869_11235	COG0402	S-adenosylhomocysteine deaminase activity
D1869_11285	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D1869_11290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1869_11310	COG1355	regulation of microtubule-based process
D1869_11315	COG0052	Belongs to the universal ribosomal protein uS2 family
D1869_11325	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D1869_11330	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1869_11335	COG0200	Binds to the 23S rRNA
D1869_11345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1869_11350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1869_11355	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1869_11365	COG0432	Pfam Uncharacterised protein family UPF0047
D1869_11375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1869_11385	COG0417	DNA replication proofreading
D1869_11420	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D1869_11455	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D1869_11475	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1869_11480	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
D1869_11515	COG2267	carboxylic ester hydrolase activity
D1869_11525	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
D1869_11530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1869_11535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D1869_11535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D1869_11560	COG0419	ATPase involved in DNA repair
D1869_11560	COG0419	ATPase involved in DNA repair
D1869_11615	COG0517	IMP dehydrogenase activity
D1869_11615	COG0516	GMP reductase activity
D1869_11635	COG3118	belongs to the thioredoxin family
D1869_11690	COG0492	ferredoxin-NADP+ reductase activity
D1869_11700	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D1869_11715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1869_11720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1869_11730	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1869_11745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1869_11750	COG0561	phosphatase activity
D1869_11775	COG0494	nUDIX hydrolase
D1869_11790	COG1618	nucleotide phosphatase activity, acting on free nucleotides
D1869_11800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D1869_11805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D1869_11805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1869_11830	COG2154	pterin-4-alpha-carbinolamine dehydratase
D1869_11850	COG0538	isocitrate dehydrogenase activity
D1869_11895	COG0500	methyltransferase
D1869_11895	COG3615	Tellurite resistance protein tehB
D1869_11920	COG2096	Adenosyltransferase
D1869_11925	COG0697	spore germination
D1869_11930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1869_11940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1869_11950	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D1869_12070	COG0069	glutamate synthase activity
D1869_12075	COG0067	glutamate synthase
D1869_12115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1869_12120	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D1869_12155	COG1695	Transcriptional regulator
D1869_12180	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D1869_12190	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1869_12195	COG0649	NAD binding
D1869_12200	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D1869_12205	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1869_12215	COG0713	ATP synthesis coupled electron transport
D1869_12220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1869_12225	COG1007	ATP synthesis coupled electron transport
D1869_12230	COG1260	myo-inositol-1-phosphate synthase
D1869_12235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1869_12235	COG0301	tRNA thio-modification
D1869_12285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1869_12295	COG0730	response to heat
D1869_12305	COG1573	uracil-dna glycosylase
D1869_12310	COG1028	Short-chain dehydrogenase reductase Sdr
D1869_12315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1869_12325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1869_12340	COG0215	cysteine-tRNA ligase activity
D1869_12345	COG2222	sugar isomerase
D1869_12355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1869_12365	COG0433	COG0433 Predicted ATPase
D1869_12375	COG1607	acyl-coa hydrolase
D1869_12380	COG1063	alcohol dehydrogenase
D1869_12395	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D1869_12400	COG1960	acyl-CoA dehydrogenase activity
D1869_12470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1869_12475	COG3959	Transketolase, thiamine diphosphate binding domain
D1869_12480	COG3958	Transketolase
D1869_12490	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D1869_12495	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1869_12500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1869_12505	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D1869_12510	COG0083	homoserine kinase activity
D1869_12515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1869_12535	COG1199	ATP-dependent helicase activity
D1869_12560	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D1869_12565	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1869_12575	COG1331	Highly conserved protein containing a thioredoxin domain
D1869_12595	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
D1869_12615	COG1192	Involved in chromosome partitioning
D1869_12625	COG0277	FAD linked oxidase domain protein
D1869_12640	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1869_12645	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D1869_12645	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1869_12665	COG0517	IMP dehydrogenase activity
D1869_12665	COG0516	GMP reductase activity
D1869_12670	COG0123	including yeast histone deacetylase and acetoin utilization protein
D1869_12675	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D1869_12720	COG1201	RNA secondary structure unwinding
D1869_12760	COG0006	proline dipeptidase activity
D1869_12780	COG1234	tRNA 3'-trailer cleavage
D1869_12785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1869_12790	COG0351	phosphomethylpyrimidine kinase
D1869_12800	COG1215	transferase activity, transferring glycosyl groups
D1869_12820	COG0463	Glycosyl transferase, family 2
D1869_12840	COG1063	alcohol dehydrogenase
D1869_12845	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D1869_12860	COG0519	Catalyzes the synthesis of GMP from XMP
D1869_12860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1869_12865	COG0501	Belongs to the peptidase M48B family
D1869_12880	COG1830	Aldolase
D1869_12895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1869_12905	COG0405	Gamma-glutamyltransferase
D1869_12920	COG1444	tRNA N-acetyltransferase activity
D1869_12945	COG0589	response to stress
D1869_12950	COG2271	Major facilitator Superfamily
D1869_12970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D1869_12990	COG0516	GMP reductase activity
D1869_12990	COG0517	IMP dehydrogenase activity
D1869_13005	COG0730	response to heat
D1869_13060	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D1869_13060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1869_13075	COG0438	transferase activity, transferring glycosyl groups
D1869_13085	COG1846	Transcriptional regulator
D1869_13155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1869_13160	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1869_13170	COG0402	S-adenosylhomocysteine deaminase activity
D1869_13180	COG1573	uracil-dna glycosylase
D1869_13205	COG0028	Belongs to the TPP enzyme family
D1869_13215	COG0535	radical SAM domain protein
D1869_13220	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1869_13240	COG1024	Enoyl-CoA hydratase
D1869_13245	COG0183	Belongs to the thiolase family
D1869_13270	COG2814	Major facilitator Superfamily
D1869_13300	COG2271	Major facilitator Superfamily
D1869_13330	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1869_13335	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D1869_13335	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1869_13355	COG0515	serine threonine protein kinase
D1869_13355	COG2815	serine threonine protein kinase
D1869_13365	COG2235	arginine
D1869_13370	COG0450	alkyl hydroperoxide reductase
D1869_13375	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
D1869_13395	COG1720	tRNA m6t6A37 methyltransferase activity
D1869_13405	COG0813	purine-nucleoside phosphorylase activity
D1869_13505	COG0530	calcium, potassium:sodium antiporter activity
D1869_13510	COG2149	membrane
D1869_13515	COG3276	selenocysteine insertion sequence binding
D1869_13520	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1869_13555	COG0531	amino acid
D1869_13560	COG1012	belongs to the aldehyde dehydrogenase family
D1869_13565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1869_13590	COG1252	NADH dehydrogenase
D1869_13600	COG0656	L-ascorbic acid biosynthetic process
D1869_13640	COG0586	Pfam SNARE associated Golgi protein
D1869_13660	COG1335	isochorismatase
D1869_13665	COG1131	(ABC) transporter
D1869_13675	COG0412	Dienelactone hydrolase
D1869_13720	COG0601	transmembrane transport
D1869_13725	COG0444	Belongs to the ABC transporter superfamily
D1869_13730	COG4608	Belongs to the ABC transporter superfamily
D1869_13755	COG0601	transmembrane transport
D1869_13760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1869_13765	COG0444	Belongs to the ABC transporter superfamily
D1869_13770	COG4608	Belongs to the ABC transporter superfamily
D1869_13780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1869_13820	COG3386	PFAM SMP-30 Gluconolaconase
D1869_13825	COG1028	Short-chain dehydrogenase reductase Sdr
D1869_13860	COG1802	Transcriptional regulator
D1869_13870	COG1373	ATPase (AAA superfamily
D1869_13875	COG4948	Mandelate Racemase Muconate Lactonizing
D1869_13880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1869_13885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1869_13945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1869_14030	COG2329	Antibiotic biosynthesis monooxygenase
D1869_14040	COG2814	Major facilitator Superfamily
D1869_14065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1869_14130	COG2181	nitrate reductase activity
D1869_14140	COG1140	nitrate reductase beta subunit
D1869_14145	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D1869_14150	COG2223	nitrite transmembrane transporter activity
D1869_14200	COG1122	ATPase activity
D1869_14230	COG0477	Major facilitator Superfamily
D1869_14445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1869_14470	COG1770	oligopeptidase
D1869_14675	COG1024	Enoyl-CoA hydratase
D1869_14680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1869_14690	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D1869_14695	COG1064	alcohol dehydrogenase
D1869_14730	COG0318	PFAM AMP-dependent synthetase and ligase
D1869_14740	COG1012	belongs to the aldehyde dehydrogenase family
D1869_14745	COG2814	Major facilitator Superfamily
D1869_14745	COG0477	Major facilitator Superfamily
D1869_14765	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1869_14770	COG1028	Short-chain dehydrogenase reductase Sdr
D1869_14780	COG1309	transcriptional regulator
D1869_14790	COG1063	alcohol dehydrogenase
D1869_14795	COG1960	acyl-CoA dehydrogenase activity
D1869_14800	COG0318	PFAM AMP-dependent synthetase and ligase
D1869_14805	COG0183	Belongs to the thiolase family
D1869_14815	COG3383	formate dehydrogenase (NAD+) activity
D1869_14825	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D1869_14830	COG1960	acyl-CoA dehydrogenase activity
D1869_14835	COG2030	dehydratase
D1869_14840	COG1960	acyl-CoA dehydrogenase activity
D1869_14865	COG2271	Major facilitator Superfamily
D1869_14875	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1869_14885	COG1024	Enoyl-CoA hydratase
D1869_14890	COG0183	Belongs to the thiolase family
D1869_14920	COG1845	cytochrome c oxidase, subunit III
D1869_14920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1869_14950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1869_14965	COG0456	acetyltransferase
D1869_14970	COG0281	malic enzyme
D1869_14980	COG1832	CoA-binding protein
D1869_15030	COG0535	radical SAM domain protein
D1869_15035	COG0656	L-ascorbic acid biosynthetic process
D1869_15075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis