locus-tag	class	description
STK_00020	ENOG4105CUG	Oligopeptidase b
STK_00320	ENOG4105DTT	CRISPR-associated helicase, cas3
STK_00365	ENOG4108M14	stage v sporulation protein t
STK_00380	ENOG4105DQ4	alcohol dehydrogenase
STK_00480	ENOG4105E39	Enoyl-CoA hydratase
STK_00520	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
STK_00540	ENOG4105CSH	Transporter
STK_00570	ENOG4105C5X	domain protein
STK_00620	ENOG4105CEY	Amp-dependent synthetase and ligase
STK_00640	ENOG4105C26	Dehydrogenase
STK_00680	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
STK_00690	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
STK_00700	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
STK_00750	ENOG4105CPQ	Dehydrogenase
STK_00760	ENOG4105C1G	acyl-Coa dehydrogenase
STK_00770	ENOG4105CEY	Amp-dependent synthetase and ligase
STK_00790	ENOG4105CHU	acetyl-coa acetyltransferase
STK_00810	ENOG4108IEG	Formate dehydrogenase Alpha subunit
STK_00840	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
STK_00850	ENOG4105D2B	acyl-CoA dehydrogenase
STK_00870	ENOG4105CC9	acyl-Coa dehydrogenase
STK_00910	ENOG4105C54	Major Facilitator superfamily
STK_00930	ENOG4105C7W	Xanthine dehydrogenase
STK_00950	ENOG4106YT9	Enoyl-CoA hydratase
STK_00960	ENOG4105CHU	acetyl-coa acetyltransferase
STK_01000	ENOG4105D82	Glutamate dehydrogenase
STK_01030	ENOG4105BZ9	Cytochrome C oxidase, subunit I
STK_01090	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
STK_01130	ENOG4107WJM	-acetyltransferase
STK_01140	ENOG4105C6K	Malic enzyme
STK_01160	ENOG4105K4P	CoA-binding domain protein
STK_01270	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
STK_01300	ENOG4105CV8	reductase
STK_01360	ENOG4105BZ9	Cytochrome C oxidase, subunit I
STK_01370	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
STK_01470	ENOG4105CB5	ATP-dependent DNA helicase recG
STK_01560	ENOG4105C5F	glutamine synthetase
STK_01650	ENOG4105CIH	Imidazole acetol-phosphate transaminase
STK_01740	ENOG4105D1F	ATP-binding protein
STK_01820	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
STK_01830	ENOG4107TSN	permease
STK_01870	ENOG4108IAJ	Nad-dependent epimerase dehydratase
STK_01890	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
STK_01900	ENOG4108KB0	deacetylase
STK_01910	ENOG4105C8Y	Acetylornithine aminotransferase
STK_01920	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
STK_01940	ENOG4105CAS	nag kinase
STK_01950	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
STK_01980	ENOG41080HJ	6-phospho 3-hexuloisomerase
STK_02020	ENOG4105C7K	acetolactate synthase
STK_02050	ENOG4105C5S	asparaginyl-tRNA synthetase
STK_02070	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
STK_02090	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
STK_02110	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
STK_02120	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
STK_02140	ENOG4105D52	delta-aminolevulinic acid dehydratase
STK_02150	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
STK_02170	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
STK_02210	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
STK_02230	ENOG4107TRG	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
STK_02260	ENOG4105DHP	deoxycytidine triphosphate deaminase
STK_02290	ENOG4105NBF	ammecr1 domain protein
STK_02350	ENOG4105DZH	s-adenosylmethionine synthetase (EC 2.5.1.6)
STK_02370	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
STK_02380	ENOG4108VA3	3-hexulose-6-phosphate synthase
STK_02420	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
STK_02435	ENOG4105VUC	UPF0237 protein
STK_02450	ENOG4105CAG	UPF0210 protein
STK_02550	ENOG4108FPN	Integrase
STK_02580	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
STK_02650	ENOG4105CIG	ABC transporter
STK_02680	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
STK_02690	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
STK_02700	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
STK_02740	ENOG4105XPM	ribosomal protein
STK_02750	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
STK_02760	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
STK_02770	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
STK_02780	ENOG4105C6K	Malic enzyme
STK_02790	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
STK_02800	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
STK_02810	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
STK_02820	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
STK_02830	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
STK_02850	ENOG4105WCJ	ec 1.1.1.193
STK_02860	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
STK_02880	ENOG4105C83	adenylosuccinate lyase
STK_02910	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
STK_02920	ENOG4105CAY	ferredoxin--nadp reductase
STK_02940	ENOG4105CQC	Prephenate dehydratase
STK_02950	ENOG4105C7B	Threonine dehydratase
STK_02990	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
STK_03030	ENOG4105NAU	thioesterase Superfamily protein
STK_03100	ENOG4108RTE	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity)
STK_03130	ENOG4108FPN	Integrase
STK_03170	ENOG4105FDK	ABC transporter
STK_03180	ENOG4107NFR	Fructose-1,6-bisphosphatase
STK_03210	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
STK_03230	ENOG4105CUT	histidyl-tRNA synthetase
STK_03300	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
STK_03320	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
STK_03390	ENOG4105CSH	Transporter
STK_03420	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
STK_03430	ENOG4105CY0	Metallo-Beta-Lactamase
STK_03440	ENOG4108MDK	Dehydrogenase
STK_03450	ENOG4108YZY	peptidylprolyl cis-trans isomerase
STK_03460	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
STK_03480	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
STK_03500	ENOG4108ZJT	translation initiation factor, Sui1
STK_03530	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
STK_03600	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
STK_03610	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
STK_03630	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
STK_03650	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
STK_03660	ENOG4105CPC	Aldo Keto reductase
STK_03740	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
STK_03760	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
STK_03770	ENOG4105E3H	phosphoglycerate mutase
STK_03810	ENOG4105EM7	Selenocysteine-specific translation elongation factor
STK_03830	ENOG4105DAT	cobalamin (vitamin b12) biosynthesis cbix protein
STK_03850	ENOG4107QYE	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
STK_03860	ENOG4107QYE	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
STK_03890	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
STK_03940	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
STK_04010	ENOG4107QRT	dEAD DEAH box helicase
STK_04030	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
STK_04040	ENOG41088YS	Glycosyl transferase (Group 1
STK_04080	ENOG4105CAT	Cytidine monophosphate kinase
STK_04120	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
STK_04140	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
STK_04180	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
STK_04190	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
STK_04200	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
STK_04220	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
STK_04240	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
STK_04250	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
STK_04260	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
STK_04270	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
STK_04275	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
STK_04280	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
STK_04330	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
STK_04370	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
STK_04380	ENOG4105C3M	thioredoxin reductase
STK_04390	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
STK_04430	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
STK_04510	ENOG4105C3G	gtp-binding protein
STK_04520	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
STK_04540	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
STK_04550	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
STK_04560	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
STK_04620	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
STK_04720	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
STK_04730	ENOG4105D1H	recombination factor protein RarA
STK_04750	ENOG4105C6E	dna polymerase iii
STK_04760	ENOG4108V1U	phospholipid-binding protein
STK_04770	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
STK_04780	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
STK_04800	ENOG4105CPQ	Dehydrogenase
STK_04840	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
STK_04850	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
STK_04870	ENOG4105EAH	synthase
STK_04880	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
STK_04890	ENOG4108VVK	transcriptional Regulator, AsnC
STK_04940	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
STK_04990	ENOG41086B8	CoB-CoM heterodisulfide reductase
STK_05020	ENOG4107R4Q	Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity)
STK_05040	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
STK_05050	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
STK_05060	ENOG4105C28	cystathionine
STK_05150	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
STK_05260	ENOG4105DWF	phosphomethylpyrimidine kinase
STK_05270	ENOG4108ZAF	Molybdopterin
STK_05380	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
STK_05430	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
STK_05470	ENOG4105ECY	inositol monophosphatase
STK_05480	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
STK_05510	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
STK_05570	ENOG4105EM7	Selenocysteine-specific translation elongation factor
STK_05600	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
STK_05630	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
STK_05700	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
STK_05730	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
STK_05740	ENOG4108RVA	ribokinase
STK_05770	ENOG4108Z4K	mutator MutT protein
STK_05780	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
STK_05790	ENOG4105EHU	Circadian clock protein KaiC
STK_05810	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
STK_05820	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
STK_05840	ENOG4105D3R	alkyl hydroperoxide reductase
STK_05870	ENOG4105BZN	citrate synthase
STK_05900	ENOG4105CQR	helicase
STK_05910	ENOG4105D8K	carboxyl transferase
STK_05930	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
STK_05950	ENOG4105D7T	ABC transporter
STK_05980	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
STK_05990	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
STK_06000	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
STK_06010	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
STK_06060	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
STK_06110	ENOG4105BZ9	Cytochrome C oxidase, subunit I
STK_06250	ENOG4105C8T	Leucyl-tRNA synthetase
STK_06270	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
STK_06300	ENOG4107R56	PP-loop domain protein
STK_06330	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
STK_06480	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
STK_06490	ENOG4105CQB	FAD linked oxidase domain protein
STK_06510	ENOG4105CEP	NADH dehydrogenase
STK_06610	ENOG4105BZU	Histidine kinase
STK_06660	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
STK_06690	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
STK_06830	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
STK_06860	ENOG4107QPV	Serine Threonine protein kinase
STK_06870	ENOG4107QN2	dihydrolipoyl dehydrogenase
STK_06910	ENOG4107QNK	)-transporter
STK_06980	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
STK_07000	ENOG4108JQ7	(ABC) transporter
STK_07010	ENOG4105C3U	ABC transporter
STK_07020	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
STK_07070	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
STK_07130	ENOG4105D2S	major facilitator superfamily
STK_07210	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
STK_07260	ENOG4105EFA	4-hydroxyphenylacetate
STK_07300	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
STK_07310	ENOG4106HK8	GPR1 FUN34 yaaH family protein
STK_07350	ENOG4105C8Y	Acetylornithine aminotransferase
STK_07430	ENOG4105VG1	fes assembly suf system protein
STK_07520	ENOG4105C7K	acetolactate synthase
STK_07560	ENOG4108IUW	ABC transporter
STK_07700	ENOG41080XP	Cbs domain
STK_07730	ENOG4105CS2	ec 3.2.1.21
STK_07790	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
STK_07830	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
STK_07900	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
STK_08020	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
STK_08060	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
STK_08070	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
STK_08100	ENOG4105D9P	serine threonine protein kinase
STK_08110	ENOG4105KME	endoribonuclease L-psp
STK_08130	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
STK_08160	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
STK_08180	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
STK_08270	ENOG4105T58	Dithiol-disulfide isomerase
STK_08330	ENOG4107QM5	aconitate hydratase
STK_08360	ENOG4105D0M	Protease HtpX homolog
STK_08410	ENOG4108I9K	permease protein
STK_08420	ENOG4105FDK	ABC transporter
STK_08500	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
STK_08520	ENOG4105CUB	amino acid
STK_08540	ENOG4105EQR	Transposase IS116 IS110 IS902
STK_08620	ENOG41089BK	Glutamine amido-transferase
STK_08720	ENOG4105CS1	NAD(P)H quinone oxidoreductase
STK_08730	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
STK_08805	ENOG4107XUC	SirA family
STK_08815	ENOG41084XP	SirA-like domain-containing protein
STK_08890	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
STK_08900	ENOG4108Z0Z	intracellular protease Pfpi family
STK_09020	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
STK_09040	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
STK_09110	ENOG4105C54	Major Facilitator superfamily
STK_09160	ENOG4105C1G	acyl-Coa dehydrogenase
STK_09220	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
STK_09340	ENOG4105JHE	Major Facilitator Superfamily
STK_09370	ENOG4108RE7	deoxyribonuclease
STK_09380	ENOG4108IXY	short-chain dehydrogenase reductase
STK_09410	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
STK_09460	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
STK_09510	ENOG4105M7V	2'-5' rna ligase
STK_09620	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
STK_09630	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
STK_09660	ENOG4105C22	threonyL-tRNA synthetase
STK_09680	ENOG4105EJZ	Glucose-1-phosphate cytidylyltransferase
STK_09710	ENOG4105CEP	NADH dehydrogenase
STK_09730	ENOG4105BZP	glycoside hydrolase 15-related
STK_09740	ENOG4105CPK	Glycosyl transferase (Group 1
STK_09750	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
STK_09760	ENOG4105DCI	Phosphohydrolase
STK_09870	ENOG4105E4P	ATPase (AAA
STK_09920	ENOG4108SZE	gCN5-related N-acetyltransferase
STK_10060	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
STK_10070	ENOG4105DWF	phosphomethylpyrimidine kinase
STK_10080	ENOG4105C8I	hydrolase, family 38
STK_10100	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
STK_10130	ENOG4105C7W	Xanthine dehydrogenase
STK_10140	ENOG4105DZC	cytosine deaminase
STK_10220	ENOG4105EW9	transcriptional regulator AsnC family
STK_10230	ENOG4108V7B	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity)
STK_10250	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
STK_10280	ENOG4105CQM	Urea amidohydrolase subunit alpha
STK_10310	ENOG4105CEU	Arginine dihydrolase
STK_10340	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
STK_10540	ENOG4107ZMQ	sugar fermentation stimulation protein
STK_10580	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
STK_10660	ENOG4105DIK	(ABC) transporter
STK_10800	ENOG4105K8R	UPF0145 protein
STK_10870	ENOG4108IPJ	Membrane
STK_10990	ENOG4105BZ1	(ABC) transporter
STK_11050	ENOG4105EG2	ABC transporter, permease
STK_11080	ENOG4105CXK	mandelate racemase muconate lactonizing
STK_11090	ENOG4105CHR	reductase
STK_11120	ENOG4105CEY	Amp-dependent synthetase and ligase
STK_11130	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
STK_11140	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
STK_11160	ENOG4105C26	Dehydrogenase
STK_11180	ENOG4107RNN	dihydropyrimidinase (EC 3.5.2.2)
STK_11200	ENOG4107SJI	Dehydrogenase
STK_11230	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
STK_11240	ENOG4105BZP	glycoside hydrolase 15-related
STK_11360	ENOG4108JJB	ABC transporter
STK_11470	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
STK_11480	ENOG4106A3M	Cytochrome p-450
STK_11510	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
STK_11530	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
STK_11680	ENOG4107RE3	peptidase, S41
STK_11700	ENOG4107TE1	transport protein
STK_11960	ENOG4108IYU	L-aspartate oxidase
STK_11970	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
STK_11980	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
STK_12000	ENOG4105DIW	FeS assembly protein SUFB
STK_12010	ENOG4105C3K	feS assembly ATPase SufC
STK_12050	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
STK_12060	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
STK_12070	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
STK_12080	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
STK_12150	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
STK_12160	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
STK_12180	ENOG4108JQ1	Dehydrogenase
STK_12190	ENOG4105GRF	N-glycosylase DNA lyase
STK_12240	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
STK_12250	ENOG4105CHM	Aminotransferase
STK_12280	ENOG4105DDQ	anthranilate synthase
STK_12290	ENOG4105CRQ	synthase (Component I)
STK_12300	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
STK_12310	ENOG4108I0Q	anthranilate phosphoribosyltransferase
STK_12320	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
STK_12330	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
STK_12335	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
STK_12350	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
STK_12410	ENOG4105CFH	Aspartokinase
STK_12420	ENOG4107QK3	aspartate-semialdehyde dehydrogenase (EC 1.2.1.11
STK_12430	ENOG4105C0B	DNA polymerase III (alpha subunit)
STK_12450	ENOG4105DBV	ornithine carbamoyltransferase
STK_12530	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
STK_12590	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
STK_12620	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
STK_12640	ENOG4105HDK	L-asparaginase
STK_12690	ENOG4108K3F	N(2),N(2)-dimethylguanosine tRNA methyltransferase
STK_12790	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
STK_12830	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
STK_12835	ENOG410855J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
STK_12850	ENOG4105VF7	tolerance protein
STK_12900	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
STK_12910	ENOG4107QRT	dEAD DEAH box helicase
STK_12990	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
STK_13010	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
STK_13020	ENOG4105E66	phosphoriboisomerase A
STK_13480	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
STK_13540	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
STK_13550	ENOG4107YZX	Universal stress protein
STK_13570	ENOG4105BZA	Phosphoglycerate kinase
STK_13640	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
STK_13660	ENOG4108VZM	50s ribosomal protein L10
STK_13680	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
STK_13700	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
STK_13800	ENOG4105C6T	cysteine synthase
STK_13830	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
STK_13840	ENOG4105DC7	peptidase M24
STK_13850	ENOG4105EUJ	GTP cyclohydrolase i
STK_13870	ENOG4105C5F	glutamine synthetase
STK_13875	ENOG4105K63	Thioredoxin
STK_13880	ENOG4105CEY	Amp-dependent synthetase and ligase
STK_13900	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
STK_13910	ENOG4108Z0R	Transferase
STK_13930	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
STK_13970	ENOG4107QHF	type ii secretion system protein e
STK_14010	ENOG4105CSM	endonuclease III
STK_14040	ENOG4107QRT	dEAD DEAH box helicase
STK_14110	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
STK_14130	ENOG4105CEV	competence damage-inducible protein
STK_14140	ENOG4105F2Z	3-oxoadipate enol-lactonase
STK_14180	ENOG4105E8R	UPF0173 metal-dependent hydrolase
STK_14220	ENOG410667J	hydrolase
STK_14230	ENOG4105CX6	glutaminyL-tRNA synthetase
STK_14260	ENOG4105CQ2	DNA polymerase
STK_14320	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
STK_14360	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
STK_14370	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
STK_14380	ENOG4106C6A	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
STK_14400	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
STK_14410	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
STK_14420	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
STK_14450	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
STK_14470	ENOG4105C7K	acetolactate synthase
STK_14490	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
STK_14520	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
STK_14530	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
STK_14550	ENOG4105C8T	Leucyl-tRNA synthetase
STK_14580	ENOG4105CIH	Imidazole acetol-phosphate transaminase
STK_14590	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
STK_14600	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
STK_14610	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
STK_14620	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
STK_14640	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
STK_14650	ENOG41083RF	phosphoribosyl-ATP pyrophosphatase
STK_14660	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
STK_14670	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
STK_14680	ENOG4105VG1	fes assembly suf system protein
STK_14700	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
STK_14710	ENOG4105K59	histidine triad (HIT) protein
STK_14730	ENOG4108VVK	transcriptional Regulator, AsnC
STK_14770	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
STK_14780	ENOG4105CD3	dihydroorotase
STK_14790	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
STK_14800	ENOG4105CXT	aspartate transcarbamylase
STK_14810	ENOG4107XPQ	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
STK_14900	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
STK_14910	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
STK_14920	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
STK_14930	ENOG4105C8V	SAICAR synthetase
STK_14940	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
STK_14950	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
STK_14980	ENOG4105C12	Phosphoribosylglycinamide synthetase
STK_14990	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
STK_15010	ENOG4105CDH	Citrulline--aspartate ligase
STK_15020	ENOG4105CH7	arginosuccinase
STK_15030	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
STK_15050	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
STK_15070	ENOG4105F35	Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity)
STK_15160	ENOG4105E39	Enoyl-CoA hydratase
STK_15180	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
STK_15220	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
STK_15240	ENOG4107YZX	Universal stress protein
STK_15250	ENOG4108EKN	Biotin protein ligase C terminal domain
STK_15260	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
STK_15270	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
STK_15320	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
STK_15330	ENOG4105DDK	oxidoreductase, beta subunit
STK_15355	ENOG4108M14	stage v sporulation protein t
STK_15370	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
STK_15420	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
STK_15430	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
STK_15440	ENOG4105C9X	ppx gppa phosphatase
STK_15470	ENOG4105D0M	Protease HtpX homolog
STK_15480	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
STK_15670	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
STK_15770	ENOG4105CJ1	ABC, transporter
STK_15820	ENOG4105CJ1	ABC, transporter
STK_15850	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
STK_16080	ENOG4105EN6	Membrane
STK_16130	ENOG4105CB5	ATP-dependent DNA helicase recG
STK_16210	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
STK_16240	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
STK_16290	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
STK_16470	ENOG4108JJB	ABC transporter
STK_16480	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
STK_16500	ENOG4105CTD	carboxy-peptidase
STK_16550	ENOG4107QR9	Iron-sulfur cluster binding protein
STK_16700	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
STK_16780	ENOG4105EYF	MMPL domain protein
STK_16800	ENOG4105CQ2	DNA polymerase
STK_17050	ENOG4105ERH	Fumarylacetoacetate hydrolase
STK_17060	ENOG4108JJB	ABC transporter
STK_17090	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
STK_17100	ENOG4108T3F	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
STK_17110	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
STK_17170	ENOG4105EQR	Transposase IS116 IS110 IS902
STK_17300	ENOG4105CJ1	ABC, transporter
STK_17350	ENOG4105CJ1	ABC, transporter
STK_17570	ENOG4107QTZ	amino acid
STK_17720	ENOG4105CJ1	ABC, transporter
STK_17750	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
STK_17760	ENOG4105C10	Electron transfer flavoprotein
STK_17840	ENOG4105KHC	sulfurtransferase
STK_17850	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
STK_17870	ENOG4105DDK	oxidoreductase, beta subunit
STK_17880	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
STK_17884	ENOG4105WGB	oxidoreductase, delta subunit
STK_17910	ENOG4105C1G	acyl-Coa dehydrogenase
STK_17930	ENOG4105BZJ	Electron transfer flavoprotein
STK_17950	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
STK_17960	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
STK_17990	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
STK_18020	ENOG4105C1G	acyl-Coa dehydrogenase
STK_18030	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
STK_18050	ENOG4105BZN	citrate synthase
STK_18060	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
STK_18080	ENOG4105CR4	methylisocitrate lyase
STK_18100	ENOG4105DXD	2-methylcitrate dehydratase
STK_18110	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
STK_18130	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
STK_18160	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
STK_18190	ENOG4107XSI	cobalt-precorrin-6y C15-methyltransferase
STK_18230	ENOG4105E4R	Precorrin-3B C17-methyltransferase
STK_18240	ENOG41081F0	Precorrin-8x methylmutase
STK_18250	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
STK_18270	ENOG4105D44	asparaginase
STK_18300	ENOG4105EHU	Circadian clock protein KaiC
STK_18370	ENOG4105WCA	Ferredoxin
STK_18390	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
STK_18400	ENOG4105DB1	molybdopterin oxidoreductase
STK_18460	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
STK_18530	ENOG4105FCD	Major Facilitator
STK_18610	ENOG4107RWR	Sodium hydrogen exchanger
STK_18640	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
STK_18680	ENOG4105CHR	reductase
STK_18730	ENOG4105EWK	phytoene
STK_18755	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
STK_18760	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
STK_18880	ENOG4105DF9	Lipoate-protein, ligase
STK_18920	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
STK_18940	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
STK_18950	ENOG4108UR0	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
STK_18960	ENOG4105DF9	Lipoate-protein, ligase
STK_19010	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
STK_19090	ENOG4105D5M	phosphate starvation-inducible protein
STK_19100	ENOG4105CGK	Exodeoxyribonuclease III
STK_19120	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
STK_19140	ENOG4105EYF	MMPL domain protein
STK_19170	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
STK_19190	ENOG4105E4P	ATPase (AAA
STK_19220	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
STK_19410	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
STK_19430	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
STK_19610	ENOG4108SHN	Glycosyl transferase, family 2
STK_19630	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
STK_19650	ENOG4108SHN	Glycosyl transferase, family 2
STK_19670	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
STK_19690	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
STK_19710	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
STK_19720	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
STK_19830	ENOG4105DCI	Phosphohydrolase
STK_20100	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
STK_20190	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
STK_20220	ENOG4105C5X	domain protein
STK_20230	ENOG4105C9Q	fumarate hydratase class II
STK_20300	ENOG4105CP7	Triose-phosphate isomerase
STK_20330	ENOG4105E0C	molybdate abc transporter
STK_20390	ENOG4107R5H	iron (metal) dependent repressor, dtxr family
STK_20420	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
STK_20450	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
STK_20460	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
STK_20490	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
STK_20560	ENOG4107QPD	alcohol dehydrogenase
STK_20570	ENOG4105ESV	Glycosyl transferase, family 4
STK_20590	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
STK_20620	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
STK_20630	ENOG4105CE9	30S ribosomal protein S2
STK_20640	ENOG4108UJD	30S ribosomal protein S9
STK_20650	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
STK_20660	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
STK_20680	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
STK_20690	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
STK_20700	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
STK_20740	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
STK_20760	ENOG4105CQ2	DNA polymerase
STK_20830	ENOG4105CRK	lysyL-tRNA synthetase
STK_20900	ENOG4105DG4	malate L-lactate dehydrogenase
STK_20940	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
STK_20950	ENOG4105DZS	Phenylacetate-CoA ligase
STK_20990	ENOG4106HB6	Alpha beta hydrolase
STK_21010	ENOG4108MYP	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
STK_21020	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
STK_21030	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
STK_21080	ENOG4107WZZ	SMC domain protein
STK_21080	ENOG4107WZZ	SMC domain protein
STK_21190	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
STK_21230	ENOG4105K63	Thioredoxin
STK_21330	ENOG4105CAY	ferredoxin--nadp reductase
STK_21360	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
STK_21390	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
STK_21430	ENOG4108K7V	UPF0284 protein
STK_21450	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
STK_21460	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
STK_21470	ENOG4105J7I	hydrolase
STK_21520	ENOG4105K59	histidine triad (HIT) protein
STK_21540	ENOG4107VIJ	nudix hydrolase
STK_21570	ENOG4105Q33	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency
STK_21590	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
STK_21600	ENOG4105C4K	Nad synthetase
STK_21660	ENOG4108HMX	isocitrate dehydrogenase (NADP)
STK_21710	ENOG4107QK3	aspartate-semialdehyde dehydrogenase (EC 1.2.1.11
STK_21720	ENOG4105C01	Dihydroxy-acid dehydratase
STK_21740	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
STK_21800	ENOG4108WBT	adenosyltransferase
STK_21830	ENOG4107Y9U	Membrane
STK_21840	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
STK_21860	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
STK_21870	ENOG4105C22	threonyL-tRNA synthetase
STK_21880	ENOG4105CY0	Metallo-Beta-Lactamase
STK_21920	ENOG4105W2C	Glycosyl transferase
STK_21980	ENOG4105CBC	glutamate synthase
STK_21990	ENOG4105EYU	Glutamine amido-transferase
STK_22030	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
STK_22040	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
STK_22150	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
STK_22170	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
STK_22180	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
STK_22190	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
STK_22200	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
STK_22215	ENOG41082X4	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
STK_22220	ENOG4105D65	subunit l
STK_22230	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
STK_22240	ENOG4105CZA	synthase
STK_22250	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
STK_22350	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
STK_22370	ENOG4108VCT	Sulfite exporter TauE/SafE
STK_22380	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
STK_22390	ENOG4105CHR	reductase
STK_22410	ENOG4105D82	Glutamate dehydrogenase
STK_22440	ENOG4105C8N	cysteinyl-tRNA synthetase
STK_22450	ENOG41086CI	Bifunctional phosphoglucose phosphomannose isomerase
STK_22510	ENOG4108S4H	thioesterase Superfamily protein
STK_22520	ENOG4105CPQ	Dehydrogenase
STK_22560	ENOG4105C1G	acyl-Coa dehydrogenase
STK_22670	ENOG4105D06	uba thif-type nad fad binding protein
STK_22680	ENOG4108HHA	Transketolase
STK_22690	ENOG4108IUS	Transketolase
STK_22710	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
STK_22720	ENOG4105D49	3-dehydroquinate synthase
STK_22730	ENOG4105E2X	shikimate dehydrogenase
STK_22740	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
STK_22760	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
STK_22770	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
STK_22800	ENOG4105DVT	helicase
STK_22830	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
STK_22860	ENOG4105C7Z	Conserved Protein
STK_22900	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
STK_22930	ENOG4107QJE	Chromosome Partitioning Protein
STK_22950	ENOG4105CQB	FAD linked oxidase domain protein
STK_22980	ENOG4105DQU	oxidoreductase, subunit beta
STK_23000	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
STK_23040	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
STK_23050	ENOG4105DGU	Histone deacetylase
STK_23070	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
STK_23150	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
STK_23170	ENOG4105C1J	atp-dependent rna helicase
STK_23180	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
STK_23230	ENOG4105DC7	peptidase M24
STK_23270	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
STK_23280	ENOG4108RVA	ribokinase
STK_23290	ENOG4105DWF	phosphomethylpyrimidine kinase
STK_23320	ENOG4105CND	Glycosyl transferase, family 2
STK_23340	ENOG4105CIF	Ornithine Cyclodeaminase
STK_23370	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
STK_23410	ENOG4105CPQ	Dehydrogenase
STK_23420	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
STK_23440	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
STK_23450	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
STK_23460	ENOG4105D0M	Protease HtpX homolog
STK_23500	ENOG41061GT	Aldolase
STK_23550	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
STK_23570	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
STK_23630	ENOG4105C54	Major Facilitator superfamily
STK_23670	ENOG4105MEW	serine threonine protein phosphatase
STK_23710	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
STK_23830	ENOG4105D1H	recombination factor protein RarA
STK_23860	ENOG4105JNK	Glycosyl transferase (Group 1
STK_23880	ENOG4105RV9	Transcriptional regulator
STK_24010	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
STK_24030	ENOG4105DZC	cytosine deaminase
STK_24040	ENOG4105EUB	pirin domain protein
STK_24050	ENOG4105E50	uracil-dna glycosylase
STK_24100	ENOG4105C7K	acetolactate synthase
STK_24120	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
STK_24130	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
STK_24170	ENOG4105CGU	Enoyl-CoA hydratase
STK_24180	ENOG4105CHU	acetyl-coa acetyltransferase
STK_24200	ENOG4105DZS	Phenylacetate-CoA ligase
STK_24220	ENOG4105JHE	Major Facilitator Superfamily
STK_24230	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
STK_24280	ENOG4105C54	Major Facilitator superfamily
STK_24330	ENOG4105DQU	oxidoreductase, subunit beta
STK_24350	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
STK_24370	ENOG4105CIG	ABC transporter
STK_24400	ENOG4105D9P	serine threonine protein kinase
STK_24410	ENOG4105CEU	Arginine dihydrolase
STK_24420	ENOG4105D3R	alkyl hydroperoxide reductase
STK_24470	ENOG4108R96	Methyltransferase, YaeB family
STK_24490	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
STK_24540	ENOG4105D2S	major facilitator superfamily
STK_24590	ENOG4105C1J	atp-dependent rna helicase
STK_24620	ENOG4105CSP	Major Facilitator Superfamily
STK_24640	ENOG4105FEU	K -dependent Na -Ca exchanger
STK_24660	ENOG4105VG5	Membrane
STK_24760	ENOG4107QTZ	amino acid
STK_24770	ENOG4105C26	Dehydrogenase
STK_24780	ENOG4105EDK	PfkB domain protein
STK_24790	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
STK_24850	ENOG4105CEP	NADH dehydrogenase
STK_24890	ENOG4105CV8	reductase
STK_24940	ENOG4107ZTW	SNARE associated Golgi
STK_25080	ENOG4105D3W	isochorismatase
STK_25090	ENOG4105CJ1	ABC, transporter
STK_25110	ENOG4105CDZ	Carboxymethylenebutenolidase (EC 3.1.1.45)
STK_25230	ENOG4108EHY	type IV secretion system
STK_25360	ENOG4105C3U	ABC transporter
STK_25370	ENOG4108JQ7	(ABC) transporter
STK_25400	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
STK_25410	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
STK_25430	ENOG4108JQ7	(ABC) transporter
STK_25450	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
STK_25460	ENOG4105CE4	GlcNAc 6-P deacetylase
STK_25490	ENOG4107PP3	Acetylornithine deacetylase
STK_25550	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
STK_25560	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
STK_25570	ENOG4107QNK	)-transporter
STK_25590	ENOG4105CTX	dehydratase
STK_25600	ENOG4105CTX	dehydratase
STK_25620	ENOG4105DRR	Transcriptional regulator, GntR family
STK_25640	ENOG4105KHC	sulfurtransferase
STK_25650	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
STK_25660	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
STK_25680	ENOG4107RIQ	Sulfate adenylate transferase
STK_25710	ENOG4105E4P	ATPase (AAA
STK_25720	ENOG4105CXK	mandelate racemase muconate lactonizing
STK_25730	ENOG4107QN2	dihydrolipoyl dehydrogenase
STK_25840	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
STK_25950	ENOG4105BZ9	Cytochrome C oxidase, subunit I
STK_26020	ENOG4105PEJ	SchA CurD domain protein
STK_26050	ENOG4105EE1	crotonyl-CoA reductase
STK_26180	ENOG4105CSH	Transporter