locus-tag	class	description
STK_00020	COG1770	oligopeptidase
STK_00320	COG1203	CRISPR-associated helicase, Cas3
STK_00365	COG2002	toxin-antitoxin pair type II binding
STK_00380	COG1064	alcohol dehydrogenase
STK_00480	COG1024	Enoyl-CoA hydratase
STK_00500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STK_00520	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
STK_00570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STK_00620	COG0318	PFAM AMP-dependent synthetase and ligase
STK_00640	COG1012	belongs to the aldehyde dehydrogenase family
STK_00650	COG0477	Major facilitator Superfamily
STK_00650	COG2814	Major facilitator Superfamily
STK_00680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
STK_00690	COG1250	3-hydroxyacyl-CoA dehydrogenase
STK_00700	COG1028	Short-chain dehydrogenase reductase Sdr
STK_00720	COG1309	transcriptional regulator
STK_00750	COG1063	alcohol dehydrogenase
STK_00760	COG1960	acyl-CoA dehydrogenase activity
STK_00770	COG0318	PFAM AMP-dependent synthetase and ligase
STK_00790	COG0183	Belongs to the thiolase family
STK_00810	COG3383	formate dehydrogenase (NAD+) activity
STK_00840	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
STK_00850	COG1960	acyl-CoA dehydrogenase activity
STK_00870	COG1960	acyl-CoA dehydrogenase activity
STK_00910	COG2271	Major facilitator Superfamily
STK_00930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
STK_00950	COG1024	Enoyl-CoA hydratase
STK_00960	COG0183	Belongs to the thiolase family
STK_01000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
STK_01030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
STK_01030	COG1845	cytochrome c oxidase, subunit III
STK_01090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
STK_01130	COG0456	acetyltransferase
STK_01140	COG0281	malic enzyme
STK_01160	COG1832	CoA-binding protein
STK_01270	COG0535	radical SAM domain protein
STK_01300	COG0656	L-ascorbic acid biosynthetic process
STK_01360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
STK_01370	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
STK_01470	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
STK_01710	COG1280	lysine exporter protein (LysE YggA)
STK_01740	COG0489	protein tyrosine kinase activity
STK_01820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
STK_01830	COG0730	response to heat
STK_01870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
STK_01890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
STK_01900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
STK_01910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
STK_01920	COG0189	ligase activity
STK_01940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
STK_01950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
STK_01980	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
STK_02020	COG0028	Belongs to the TPP enzyme family
STK_02050	COG0017	Asparaginyl-tRNA synthetase
STK_02070	COG0585	pseudouridine synthase activity
STK_02090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STK_02110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
STK_02110	COG1648	precorrin-2 dehydrogenase activity
STK_02120	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
STK_02140	COG0113	porphobilinogen synthase activity
STK_02150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
STK_02170	COG0181	hydroxymethylbilane synthase activity
STK_02210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
STK_02210	COG2022	thiamine diphosphate biosynthetic process
STK_02230	COG1793	dna ligase
STK_02290	COG2078	PFAM AMMECR1 domain protein
STK_02350	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
STK_02370	COG0504	CTP synthase activity
STK_02380	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
STK_02420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
STK_02450	COG2848	UPF0210 protein
STK_02580	COG0456	acetyltransferase
STK_02680	COG0051	transcription antitermination factor activity, RNA binding
STK_02690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
STK_02740	COG1358	cellular component organization or biogenesis
STK_02750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
STK_02760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
STK_02770	COG0085	RNA polymerase activity
STK_02780	COG0281	malic enzyme
STK_02790	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
STK_02800	COG0105	UTP biosynthetic process
STK_02810	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
STK_02820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
STK_02830	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
STK_02850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
STK_02860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
STK_02880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
STK_02910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
STK_02920	COG0492	ferredoxin-NADP+ reductase activity
STK_02940	COG0077	Prephenate dehydratase
STK_02950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
STK_02990	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
STK_02990	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
STK_03030	COG1607	acyl-coa hydrolase
STK_03100	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
STK_03170	COG1121	(ABC) transporter
STK_03180	COG1980	fructose-bisphosphate aldolase activity
STK_03210	COG0459	protein refolding
STK_03230	COG0124	histidyl-tRNA synthetase
STK_03300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STK_03320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
STK_03390	COG0477	Major facilitator Superfamily
STK_03420	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
STK_03430	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
STK_03450	COG1047	Peptidyl-prolyl cis-trans
STK_03460	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
STK_03480	COG3383	formate dehydrogenase (NAD+) activity
STK_03500	COG0023	Translation Initiation Factor
STK_03530	COG0423	glycine-tRNA ligase activity
STK_03600	COG0163	prenyltransferase activity
STK_03610	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
STK_03630	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
STK_03650	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
STK_03660	COG0667	Aldo Keto reductase
STK_03740	COG1110	DNA topoisomerase II activity
STK_03760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STK_03770	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
STK_03850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
STK_03860	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
STK_03890	COG1797	cobyrinic acid a,c-diamide synthase activity
STK_03940	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
STK_04010	COG1201	RNA secondary structure unwinding
STK_04030	COG2813	Specifically methylates the guanine in position
STK_04040	COG0438	transferase activity, transferring glycosyl groups
STK_04080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
STK_04120	COG0200	Binds to the 23S rRNA
STK_04140	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
STK_04180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
STK_04190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
STK_04200	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
STK_04220	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
STK_04237	COG0255	Belongs to the universal ribosomal protein uL29 family
STK_04240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
STK_04250	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
STK_04260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
STK_04270	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
STK_04275	COG0089	rRNA binding
STK_04280	COG0088	Forms part of the polypeptide exit tunnel
STK_04330	COG0473	3-isopropylmalate dehydrogenase activity
STK_04370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
STK_04380	COG0492	ferredoxin-NADP+ reductase activity
STK_04390	COG0322	excinuclease ABC activity
STK_04430	COG1185	polyribonucleotide nucleotidyltransferase activity
STK_04510	COG0012	GTP binding
STK_04520	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
STK_04540	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
STK_04550	COG2264	protein methyltransferase activity
STK_04560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
STK_04620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
STK_04720	COG0315	cyclic pyranopterin monophosphate synthase activity
STK_04730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
STK_04750	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
STK_04760	COG1881	PFAM PEBP family protein
STK_04770	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
STK_04780	COG0154	amidase activity
STK_04800	COG1063	alcohol dehydrogenase
STK_04840	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
STK_04850	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
STK_04870	COG0142	geranyltranstransferase activity
STK_04880	COG0189	ligase activity
STK_04890	COG1522	sequence-specific DNA binding
STK_04940	COG0644	oxidoreductase
STK_04970	COG1053	succinate dehydrogenase
STK_04990	COG2048	Heterodisulfide reductase, subunit B
STK_05010	COG2304	oxidoreductase activity
STK_05020	COG0714	Associated with various cellular activities
STK_05040	COG0303	'Molybdopterin
STK_05050	COG0083	homoserine kinase activity
STK_05060	COG0626	cystathionine gamma-synthase activity
STK_05140	COG0183	Belongs to the thiolase family
STK_05150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STK_05230	COG1215	transferase activity, transferring glycosyl groups
STK_05260	COG0351	phosphomethylpyrimidine kinase
STK_05270	COG0314	molybdopterin synthase activity
STK_05380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
STK_05430	COG0720	synthase
STK_05480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STK_05510	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
STK_05550	COG0071	Belongs to the small heat shock protein (HSP20) family
STK_05600	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
STK_05630	COG1648	precorrin-2 dehydrogenase activity
STK_05630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
STK_05700	COG0430	RNA-3'-phosphate cyclase activity
STK_05730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
STK_05740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
STK_05750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STK_05770	COG1051	belongs to the nudix hydrolase family
STK_05780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
STK_05780	COG0519	Catalyzes the synthesis of GMP from XMP
STK_05790	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
STK_05810	COG1515	deoxyribonuclease V activity
STK_05820	COG1335	isochorismatase
STK_05840	COG0450	alkyl hydroperoxide reductase
STK_05870	COG0372	Belongs to the citrate synthase family
STK_05900	COG4581	dead DEAH box helicase
STK_05910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
STK_05930	COG0439	Biotin carboxylase
STK_05950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
STK_05950	COG1116	anion transmembrane transporter activity
STK_05955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
STK_05980	COG0805	protein transport
STK_05990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
STK_06000	COG0066	3-isopropylmalate dehydratase activity
STK_06010	COG0778	Nitroreductase
STK_06060	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
STK_06110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
STK_06250	COG0495	leucyl-tRNA aminoacylation
STK_06270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
STK_06300	COG0037	tRNA processing
STK_06330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
STK_06380	COG0475	glutathione-regulated potassium exporter activity
STK_06390	COG0243	molybdopterin cofactor binding
STK_06460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
STK_06480	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
STK_06490	COG0277	FAD linked oxidase domain protein
STK_06510	COG1252	NADH dehydrogenase
STK_06610	COG0004	ammonium transporteR
STK_06690	COG0584	glycerophosphoryl diester phosphodiesterase
STK_06760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
STK_06830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
STK_06870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
STK_06980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
STK_06980	COG0574	Belongs to the PEP-utilizing enzyme family
STK_07000	COG4608	Belongs to the ABC transporter superfamily
STK_07010	COG0444	Belongs to the ABC transporter superfamily
STK_07020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STK_07210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
STK_07230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
STK_07260	COG2368	4-hydroxyphenylacetate
STK_07280	COG0475	glutathione-regulated potassium exporter activity
STK_07300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STK_07310	COG1584	GPR1 FUN34 yaaH family protein
STK_07350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
STK_07430	COG2151	metal-sulfur cluster biosynthetic enzyme
STK_07520	COG0028	Belongs to the TPP enzyme family
STK_07560	COG4555	ABC transporter
STK_07690	COG0455	bacterial-type flagellum organization
STK_07700	COG0517	IMP dehydrogenase activity
STK_07780	COG0515	serine threonine protein kinase
STK_07790	COG4946	Tricorn protease homolog
STK_07790	COG0823	Involved in the tonB-independent uptake of proteins
STK_07790	COG1506	peptidase
STK_07830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STK_07900	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
STK_08020	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
STK_08060	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
STK_08070	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
STK_08130	COG0517	IMP dehydrogenase activity
STK_08130	COG0516	GMP reductase activity
STK_08160	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
STK_08180	COG0297	glycogen (starch) synthase activity
STK_08190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
STK_08220	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
STK_08230	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
STK_08330	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
STK_08360	COG0501	Belongs to the peptidase M48B family
STK_08410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
STK_08500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
STK_08520	COG0531	amino acid
STK_08540	COG3547	Transposase (IS116 IS110 IS902 family)
STK_08730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STK_08740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STK_08805	COG0425	Belongs to the sulfur carrier protein TusA family
STK_08815	COG0425	Belongs to the sulfur carrier protein TusA family
STK_08890	COG0415	Belongs to the DNA photolyase family
STK_08900	COG0693	protein deglycase activity
STK_09020	COG1136	(ABC) transporter
STK_09040	COG1136	(ABC) transporter
STK_09040	COG0577	efflux transmembrane transporter activity
STK_09110	COG2814	Major facilitator Superfamily
STK_09160	COG1960	acyl-CoA dehydrogenase activity
STK_09200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
STK_09220	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
STK_09340	COG2814	Major facilitator Superfamily
STK_09370	COG0084	hydrolase, TatD family'
STK_09380	COG0300	oxidoreductase activity
STK_09410	COG1185	polyribonucleotide nucleotidyltransferase activity
STK_09460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
STK_09510	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
STK_09630	COG0045	succinate-CoA ligase (ADP-forming) activity
STK_09660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
STK_09680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
STK_09710	COG1252	NADH dehydrogenase
STK_09730	COG3387	PFAM Glycoside hydrolase 15-related
STK_09740	COG0438	transferase activity, transferring glycosyl groups
STK_09750	COG0813	purine-nucleoside phosphorylase activity
STK_09760	COG1078	dGTPase activity
STK_09870	COG1373	ATPase (AAA superfamily
STK_09920	COG0454	-acetyltransferase
STK_10060	COG0477	Major facilitator Superfamily
STK_10070	COG0352	thiamine-phosphate diphosphorylase activity
STK_10070	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
STK_10070	COG0351	phosphomethylpyrimidine kinase
STK_10080	COG0383	alpha-mannosidase activity
STK_10100	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
STK_10130	COG2080	2 iron, 2 sulfur cluster binding
STK_10130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
STK_10140	COG0402	S-adenosylhomocysteine deaminase activity
STK_10220	COG1522	sequence-specific DNA binding
STK_10230	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
STK_10250	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
STK_10280	COG0804	urea catabolic process
STK_10310	COG2235	arginine
STK_10340	COG4133	protoheme IX ABC transporter activity
STK_10380	COG0433	COG0433 Predicted ATPase
STK_10450	COG0455	bacterial-type flagellum organization
STK_10540	COG1489	DNA binding
STK_10580	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
STK_10660	COG1121	(ABC) transporter
STK_10800	COG0393	Putative heavy-metal-binding
STK_10870	COG0697	spore germination
STK_10940	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
STK_10990	COG1132	(ABC) transporter
STK_11040	COG1175	transmembrane transport
STK_11050	COG3833	ABC-type maltose transport systems, permease component
STK_11060	COG3842	ATPase activity
STK_11080	COG4948	Mandelate Racemase Muconate Lactonizing
STK_11090	COG1028	Short-chain dehydrogenase reductase Sdr
STK_11120	COG0318	PFAM AMP-dependent synthetase and ligase
STK_11130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
STK_11160	COG1012	belongs to the aldehyde dehydrogenase family
STK_11180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
STK_11200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
STK_11200	COG0167	dihydroorotate dehydrogenase activity
STK_11230	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
STK_11240	COG3387	PFAM Glycoside hydrolase 15-related
STK_11360	COG1122	ATPase activity
STK_11480	COG2124	cytochrome p450
STK_11510	COG1401	restriction endodeoxyribonuclease activity
STK_11530	COG1401	restriction endodeoxyribonuclease activity
STK_11640	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
STK_11680	COG4946	Tricorn protease homolog
STK_11680	COG0793	Belongs to the peptidase S41A family
STK_11700	COG2271	Major facilitator Superfamily
STK_11900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STK_11960	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
STK_11970	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
STK_11980	COG0157	Belongs to the NadC ModD family
STK_12000	COG0719	Fe-S assembly protein
STK_12010	COG0396	ATPase activity
STK_12050	COG0509	glycine decarboxylation via glycine cleavage system
STK_12060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
STK_12070	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
STK_12080	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
STK_12150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STK_12160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
STK_12180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
STK_12190	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
STK_12240	COG0525	valine-tRNA ligase activity
STK_12250	COG0436	Aminotransferase
STK_12280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
STK_12280	COG0512	Glutamine amidotransferase of anthranilate synthase
STK_12290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
STK_12300	COG0135	phosphoribosylanthranilate isomerase activity
STK_12310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
STK_12320	COG0159	tryptophan synthase activity
STK_12330	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
STK_12335	COG1254	Belongs to the acylphosphatase family
STK_12350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
STK_12350	COG0574	Belongs to the PEP-utilizing enzyme family
STK_12410	COG0460	homoserine dehydrogenase
STK_12410	COG0527	aspartate kinase activity
STK_12430	COG0587	DNA-directed DNA polymerase activity
STK_12450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
STK_12530	COG0459	protein refolding
STK_12590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
STK_12620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
STK_12640	COG0252	asparaginase activity
STK_12690	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
STK_12790	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
STK_12790	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
STK_12830	COG0154	amidase activity
STK_12835	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
STK_12850	COG1324	tolerance protein
STK_12900	COG1110	DNA topoisomerase II activity
STK_12910	COG1201	RNA secondary structure unwinding
STK_12960	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
STK_12970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
STK_12990	COG1028	Short-chain dehydrogenase reductase Sdr
STK_13010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
STK_13020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
STK_13480	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
STK_13540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
STK_13550	COG0589	response to stress
STK_13570	COG0126	phosphoglycerate kinase activity
STK_13640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
STK_13660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
STK_13680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
STK_13700	COG0552	protein localization to endoplasmic reticulum
STK_13800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
STK_13830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
STK_13840	COG0006	proline dipeptidase activity
STK_13850	COG0302	gtp cyclohydrolase
STK_13880	COG0318	PFAM AMP-dependent synthetase and ligase
STK_13910	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
STK_13970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
STK_14010	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
STK_14040	COG1201	RNA secondary structure unwinding
STK_14110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
STK_14140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
STK_14180	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
STK_14190	COG0024	Methionine aminopeptidase
STK_14220	COG0561	phosphatase activity
STK_14230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
STK_14260	COG0417	DNA replication proofreading
STK_14320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
STK_14360	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
STK_14370	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
STK_14380	COG1394	ATPase activity, coupled to movement of substances
STK_14410	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
STK_14420	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
STK_14450	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
STK_14470	COG0028	Belongs to the TPP enzyme family
STK_14490	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
STK_14510	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
STK_14520	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
STK_14530	COG0037	tRNA processing
STK_14550	COG0495	leucyl-tRNA aminoacylation
STK_14580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
STK_14590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
STK_14600	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
STK_14610	COG0131	Imidazoleglycerol-phosphate dehydratase
STK_14620	COG0107	imidazoleglycerol-phosphate synthase activity
STK_14640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
STK_14650	COG0140	phosphoribosyl-ATP diphosphatase activity
STK_14660	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
STK_14670	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
STK_14680	COG2151	metal-sulfur cluster biosynthetic enzyme
STK_14690	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
STK_14700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STK_14710	COG0537	adenosine 5'-monophosphoramidase activity
STK_14730	COG1522	sequence-specific DNA binding
STK_14770	COG0167	dihydroorotate dehydrogenase activity
STK_14780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
STK_14790	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
STK_14800	COG0540	Belongs to the ATCase OTCase family
STK_14810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
STK_14820	COG0284	orotidine-5'-phosphate decarboxylase activity
STK_14900	COG0602	queuosine metabolic process
STK_14910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
STK_14920	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
STK_14920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
STK_14930	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
STK_14940	COG0047	phosphoribosylformylglycinamidine synthase activity
STK_14950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
STK_14960	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
STK_14970	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
STK_14980	COG0151	Belongs to the GarS family
STK_14990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
STK_15010	COG0137	argininosuccinate synthase activity
STK_15030	COG0505	Belongs to the CarA family
STK_15050	COG0189	ligase activity
STK_15070	COG1250	3-hydroxyacyl-CoA dehydrogenase
STK_15160	COG1024	Enoyl-CoA hydratase
STK_15180	COG1612	heme a metabolic process
STK_15180	COG0109	protoheme IX farnesyltransferase activity
STK_15190	COG0460	homoserine dehydrogenase
STK_15220	COG0312	modulator of DNA gyrase
STK_15240	COG0589	response to stress
STK_15260	COG0009	L-threonylcarbamoyladenylate synthase
STK_15270	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STK_15320	COG0674	pyruvate-flavodoxin oxidoreductase activity
STK_15330	COG1013	pyruvate-flavodoxin oxidoreductase activity
STK_15355	COG2002	toxin-antitoxin pair type II binding
STK_15370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
STK_15420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
STK_15430	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
STK_15460	COG2062	phosphohistidine phosphatase, SixA
STK_15480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STK_15670	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
STK_15680	COG2308	Evidence 4 Homologs of previously reported genes of
STK_15690	COG1305	Transglutaminase-like
STK_15770	COG1131	(ABC) transporter
STK_15820	COG1131	(ABC) transporter
STK_15850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STK_16080	COG2860	membrane
STK_16130	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
STK_16210	COG2226	methyltransferase
STK_16240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
STK_16480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STK_16490	COG0601	transmembrane transport
STK_16500	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
STK_16520	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
STK_16550	COG1139	Iron-sulfur cluster binding protein
STK_16780	COG1033	growth of symbiont in host cell
STK_16780	COG2409	Drug exporters of the RND superfamily
STK_16800	COG0417	DNA replication proofreading
STK_17050	COG0179	Fumarylacetoacetate (FAA) hydrolase
STK_17060	COG4172	Belongs to the ABC transporter superfamily
STK_17100	COG1846	Transcriptional regulator
STK_17110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STK_17150	COG2217	Heavy metal translocating P-type atpase
STK_17170	COG3547	Transposase (IS116 IS110 IS902 family)
STK_17300	COG1131	(ABC) transporter
STK_17350	COG1131	(ABC) transporter
STK_17570	COG0531	amino acid
STK_17720	COG1131	(ABC) transporter
STK_17750	COG0644	oxidoreductase
STK_17760	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
STK_17840	COG2897	thiosulfate sulfurtransferase activity
STK_17850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
STK_17870	COG1013	pyruvate-flavodoxin oxidoreductase activity
STK_17880	COG0674	pyruvate-flavodoxin oxidoreductase activity
STK_17884	COG1144	Oxidoreductase
STK_17910	COG1960	acyl-CoA dehydrogenase activity
STK_17930	COG2086	electron transfer activity
STK_17950	COG0644	oxidoreductase
STK_17990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
STK_18020	COG1960	acyl-CoA dehydrogenase activity
STK_18030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STK_18050	COG0372	Belongs to the citrate synthase family
STK_18060	COG0517	IMP dehydrogenase activity
STK_18060	COG0516	GMP reductase activity
STK_18080	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
STK_18100	COG2079	MmgE PrpD family protein
STK_18110	COG0039	L-malate dehydrogenase activity
STK_18130	COG1968	undecaprenyl-diphosphatase activity
STK_18270	COG1446	asparaginase
STK_18300	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
STK_18370	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
STK_18390	COG0437	4 iron, 4 sulfur cluster binding
STK_18400	COG0243	molybdopterin cofactor binding
STK_18460	COG3386	PFAM SMP-30 Gluconolaconase
STK_18610	COG0475	glutathione-regulated potassium exporter activity
STK_18640	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
STK_18650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
STK_18755	COG0425	Belongs to the sulfur carrier protein TusA family
STK_18760	COG2210	Belongs to the sulfur carrier protein TusA family
STK_18880	COG0095	Lipoate-protein ligase
STK_18920	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
STK_18940	COG0509	glycine decarboxylation via glycine cleavage system
STK_18950	COG0509	glycine decarboxylation via glycine cleavage system
STK_18960	COG0095	Lipoate-protein ligase
STK_19010	COG1914	H( )-stimulated, divalent metal cation uptake system
STK_19090	COG1702	phosphate starvation-inducible protein PhoH
STK_19100	COG0708	Exodeoxyribonuclease III
STK_19120	COG1444	tRNA N-acetyltransferase activity
STK_19180	COG1175	transmembrane transport
STK_19190	COG1373	ATPase (AAA superfamily
STK_19220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
STK_19410	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
STK_19560	COG2192	nodulation
STK_19573	COG2192	nodulation
STK_19610	COG1215	transferase activity, transferring glycosyl groups
STK_19630	COG0438	transferase activity, transferring glycosyl groups
STK_19650	COG1215	transferase activity, transferring glycosyl groups
STK_19670	COG2264	protein methyltransferase activity
STK_19680	COG0463	Glycosyl transferase, family 2
STK_19680	COG1216	Glycosyl transferase, family 2
STK_19830	COG1078	dGTPase activity
STK_19960	COG2815	serine threonine protein kinase
STK_19960	COG0515	serine threonine protein kinase
STK_20190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STK_20220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STK_20230	COG0114	fumarate hydratase activity
STK_20300	COG0149	triose-phosphate isomerase activity
STK_20390	COG1321	iron dependent repressor
STK_20420	COG2226	methyltransferase
STK_20450	COG0303	'Molybdopterin
STK_20460	COG0746	molybdenum cofactor guanylyltransferase activity
STK_20490	COG0402	S-adenosylhomocysteine deaminase activity
STK_20560	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
STK_20570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
STK_20620	COG1355	regulation of microtubule-based process
STK_20630	COG0052	Belongs to the universal ribosomal protein uS2 family
STK_20640	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
STK_20650	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
STK_20660	COG0200	Binds to the 23S rRNA
STK_20680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
STK_20690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
STK_20700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
STK_20720	COG0432	Pfam Uncharacterised protein family UPF0047
STK_20740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
STK_20760	COG0417	DNA replication proofreading
STK_20830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
STK_20900	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
STK_20940	COG1250	3-hydroxyacyl-CoA dehydrogenase
STK_20950	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
STK_20960	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STK_20990	COG2267	carboxylic ester hydrolase activity
STK_21010	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
STK_21020	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
STK_21030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
STK_21030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
STK_21080	COG0419	ATPase involved in DNA repair
STK_21080	COG0419	ATPase involved in DNA repair
STK_21190	COG0517	IMP dehydrogenase activity
STK_21190	COG0516	GMP reductase activity
STK_21230	COG3118	belongs to the thioredoxin family
STK_21330	COG0492	ferredoxin-NADP+ reductase activity
STK_21360	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
STK_21390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STK_21400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
STK_21430	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
STK_21460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
STK_21470	COG0561	phosphatase activity
STK_21540	COG0494	nUDIX hydrolase
STK_21570	COG1618	nucleotide phosphatase activity, acting on free nucleotides
STK_21590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
STK_21600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
STK_21600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
STK_21625	COG2154	pterin-4-alpha-carbinolamine dehydratase
STK_21660	COG0538	isocitrate dehydrogenase activity
STK_21740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
STK_21800	COG2096	Adenosyltransferase
STK_21830	COG0697	spore germination
STK_21840	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
STK_21860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
STK_21880	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
STK_21980	COG0069	glutamate synthase activity
STK_21990	COG0067	glutamate synthase
STK_22030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
STK_22040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
STK_22100	COG1695	Transcriptional regulator
STK_22150	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
STK_22170	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STK_22180	COG0649	NAD binding
STK_22200	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STK_22215	COG0713	ATP synthesis coupled electron transport
STK_22220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
STK_22230	COG1007	ATP synthesis coupled electron transport
STK_22240	COG1260	myo-inositol-1-phosphate synthase
STK_22250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
STK_22250	COG0301	tRNA thio-modification
STK_22350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
STK_22370	COG0730	response to heat
STK_22380	COG1573	uracil-dna glycosylase
STK_22390	COG1028	Short-chain dehydrogenase reductase Sdr
STK_22410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
STK_22440	COG0215	cysteine-tRNA ligase activity
STK_22450	COG2222	sugar isomerase
STK_22490	COG0433	COG0433 Predicted ATPase
STK_22510	COG1607	acyl-coa hydrolase
STK_22520	COG1063	alcohol dehydrogenase
STK_22560	COG1960	acyl-CoA dehydrogenase activity
STK_22670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
STK_22680	COG3959	Transketolase, thiamine diphosphate binding domain
STK_22690	COG3958	Transketolase
STK_22710	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
STK_22720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
STK_22730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
STK_22740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
STK_22760	COG0083	homoserine kinase activity
STK_22770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
STK_22800	COG1199	ATP-dependent helicase activity
STK_22830	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
STK_22840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
STK_22860	COG1331	Highly conserved protein containing a thioredoxin domain
STK_22900	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
STK_22930	COG1192	Involved in chromosome partitioning
STK_22950	COG0277	FAD linked oxidase domain protein
STK_22980	COG1013	pyruvate-flavodoxin oxidoreductase activity
STK_23000	COG0674	pyruvate-flavodoxin oxidoreductase activity
STK_23000	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
STK_23040	COG0517	IMP dehydrogenase activity
STK_23040	COG0516	GMP reductase activity
STK_23050	COG0123	including yeast histone deacetylase and acetoin utilization protein
STK_23070	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
STK_23170	COG0513	Belongs to the DEAD box helicase family
STK_23230	COG0006	proline dipeptidase activity
STK_23270	COG1234	tRNA 3'-trailer cleavage
STK_23280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
STK_23290	COG0352	thiamine-phosphate diphosphorylase activity
STK_23290	COG0351	phosphomethylpyrimidine kinase
STK_23320	COG1215	transferase activity, transferring glycosyl groups
STK_23370	COG0463	Glycosyl transferase, family 2
STK_23410	COG1063	alcohol dehydrogenase
STK_23420	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
STK_23450	COG0519	Catalyzes the synthesis of GMP from XMP
STK_23450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
STK_23460	COG0501	Belongs to the peptidase M48B family
STK_23500	COG1830	Aldolase
STK_23530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
STK_23550	COG0405	Gamma-glutamyltransferase
STK_23570	COG1444	tRNA N-acetyltransferase activity
STK_23620	COG0589	response to stress
STK_23630	COG2271	Major facilitator Superfamily
STK_23670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
STK_23710	COG0516	GMP reductase activity
STK_23710	COG0517	IMP dehydrogenase activity
STK_23730	COG0730	response to heat
STK_23830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
STK_23830	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
STK_23860	COG0438	transferase activity, transferring glycosyl groups
STK_23880	COG1846	Transcriptional regulator
STK_24010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STK_24020	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
STK_24030	COG0402	S-adenosylhomocysteine deaminase activity
STK_24050	COG1573	uracil-dna glycosylase
STK_24100	COG0028	Belongs to the TPP enzyme family
STK_24120	COG0535	radical SAM domain protein
STK_24130	COG1250	3-hydroxyacyl-CoA dehydrogenase
STK_24170	COG1024	Enoyl-CoA hydratase
STK_24180	COG0183	Belongs to the thiolase family
STK_24200	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
STK_24220	COG2814	Major facilitator Superfamily
STK_24280	COG2271	Major facilitator Superfamily
STK_24330	COG1013	pyruvate-flavodoxin oxidoreductase activity
STK_24350	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
STK_24350	COG0674	pyruvate-flavodoxin oxidoreductase activity
STK_24400	COG0515	serine threonine protein kinase
STK_24400	COG2815	serine threonine protein kinase
STK_24410	COG2235	arginine
STK_24420	COG0450	alkyl hydroperoxide reductase
STK_24430	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
STK_24470	COG1720	tRNA m6t6A37 methyltransferase activity
STK_24490	COG0813	purine-nucleoside phosphorylase activity
STK_24540	COG2271	Major facilitator Superfamily
STK_24620	COG2271	Major facilitator Superfamily
STK_24640	COG0530	calcium, potassium:sodium antiporter activity
STK_24660	COG2149	membrane
STK_24700	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
STK_24760	COG0531	amino acid
STK_24770	COG1012	belongs to the aldehyde dehydrogenase family
STK_24780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
STK_24850	COG1252	NADH dehydrogenase
STK_24890	COG0656	L-ascorbic acid biosynthetic process
STK_24940	COG0586	Pfam SNARE associated Golgi protein
STK_25080	COG1335	isochorismatase
STK_25090	COG1131	(ABC) transporter
STK_25110	COG0412	Dienelactone hydrolase
STK_25230	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
STK_25350	COG0601	transmembrane transport
STK_25360	COG0444	Belongs to the ABC transporter superfamily
STK_25370	COG4608	Belongs to the ABC transporter superfamily
STK_25400	COG0601	transmembrane transport
STK_25410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STK_25420	COG0444	Belongs to the ABC transporter superfamily
STK_25430	COG4608	Belongs to the ABC transporter superfamily
STK_25450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
STK_25490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
STK_25550	COG3386	PFAM SMP-30 Gluconolaconase
STK_25560	COG1028	Short-chain dehydrogenase reductase Sdr
STK_25570	COG2814	Major facilitator Superfamily
STK_25590	COG2721	sulfolactate sulfo-lyase activity
STK_25600	COG2721	sulfolactate sulfo-lyase activity
STK_25620	COG1802	Transcriptional regulator
STK_25640	COG2897	thiosulfate sulfurtransferase activity
STK_25660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
STK_25680	COG2046	Belongs to the sulfate adenylyltransferase family
STK_25710	COG1373	ATPase (AAA superfamily
STK_25720	COG4948	Mandelate Racemase Muconate Lactonizing
STK_25730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
STK_25740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
STK_25750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STK_25840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STK_26020	COG2329	Antibiotic biosynthesis monooxygenase
STK_26075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
STK_26180	COG0477	Major facilitator Superfamily