locus-tag	class	description
SUTH_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SUTH_00002	COG0592	DNA-directed DNA polymerase activity
SUTH_00004	COG0741	lytic transglycosylase activity
SUTH_00006	COG0513	Belongs to the DEAD box helicase family
SUTH_00026	COG0004	ammonium transporteR
SUTH_00027	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SUTH_00029	COG0494	nUDIX hydrolase
SUTH_00030	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
SUTH_00031	COG0237	dephospho-CoA kinase activity
SUTH_00033	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SUTH_00034	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SUTH_00036	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SUTH_00039	COG3744	PilT protein domain protein
SUTH_00048	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SUTH_00049	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SUTH_00049	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SUTH_00051	COG3852	Histidine kinase
SUTH_00054	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SUTH_00056	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SUTH_00057	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SUTH_00058	COG1944	ATP diphosphatase activity
SUTH_00059	COG3568	Endonuclease Exonuclease Phosphatase
SUTH_00060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SUTH_00062	COG1126	abc transporter atp-binding protein
SUTH_00063	COG0765	amino acid transport
SUTH_00064	COG0765	amino acid transport
SUTH_00065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SUTH_00066	COG5265	(ABC) transporter
SUTH_00069	COG0628	permease
SUTH_00070	COG1309	transcriptional regulator
SUTH_00071	COG0183	Belongs to the thiolase family
SUTH_00076	COG2169	Transcriptional regulator
SUTH_00076	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SUTH_00078	COG1607	acyl-coa hydrolase
SUTH_00080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SUTH_00082	COG0791	NLP P60 protein
SUTH_00085	COG1309	transcriptional regulator
SUTH_00086	COG1024	Enoyl-CoA hydratase
SUTH_00088	COG1960	acyl-CoA dehydrogenase activity
SUTH_00089	COG1960	acyl-CoA dehydrogenase activity
SUTH_00090	COG0183	Belongs to the thiolase family
SUTH_00091	COG1024	Enoyl-CoA hydratase
SUTH_00091	COG1250	3-hydroxyacyl-CoA dehydrogenase
SUTH_00092	COG0559	Belongs to the binding-protein-dependent transport system permease family
SUTH_00093	COG0559	Belongs to the binding-protein-dependent transport system permease family
SUTH_00096	COG1022	Amp-dependent synthetase and ligase
SUTH_00104	COG0583	DNA-binding transcription factor activity
SUTH_00105	COG1592	Rubrerythrin
SUTH_00106	COG0247	lactate metabolic process
SUTH_00111	COG0513	Belongs to the DEAD box helicase family
SUTH_00115	COG2922	Belongs to the Smg family
SUTH_00116	COG0758	DNA mediated transformation
SUTH_00118	COG0242	peptide deformylase activity
SUTH_00119	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SUTH_00120	COG0793	Belongs to the peptidase S41A family
SUTH_00128	COG2204	response regulator
SUTH_00129	COG0569	domain protein
SUTH_00131	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SUTH_00132	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SUTH_00133	COG3039	Transposase
SUTH_00135	COG2258	MOSC domain
SUTH_00136	COG1940	carbohydrate kinase activity
SUTH_00139	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SUTH_00147	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SUTH_00149	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SUTH_00150	COG1560	Kdo2-lipid A biosynthetic process
SUTH_00155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SUTH_00161	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SUTH_00163	COG0386	Belongs to the glutathione peroxidase family
SUTH_00165	COG3012	SEC-C Motif Domain Protein
SUTH_00168	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SUTH_00169	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SUTH_00174	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SUTH_00175	COG0459	protein refolding
SUTH_00178	COG0642	Histidine kinase
SUTH_00180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SUTH_00184	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SUTH_00185	COG3162	membrane
SUTH_00187	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SUTH_00188	COG1028	Short-chain dehydrogenase reductase Sdr
SUTH_00191	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SUTH_00192	COG0799	negative regulation of ribosome biogenesis
SUTH_00193	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SUTH_00194	COG0424	maF-like protein
SUTH_00195	COG1530	ribonuclease E activity
SUTH_00198	COG0746	molybdenum cofactor guanylyltransferase activity
SUTH_00201	COG0509	glycine decarboxylation via glycine cleavage system
SUTH_00202	COG2032	superoxide dismutase activity
SUTH_00203	COG3276	selenocysteine insertion sequence binding
SUTH_00204	COG1305	Transglutaminase-like
SUTH_00205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SUTH_00210	COG3058	Necessary for formate dehydrogenase activity
SUTH_00211	COG2864	formate dehydrogenase
SUTH_00212	COG0437	4 iron, 4 sulfur cluster binding
SUTH_00213	COG0243	molybdopterin cofactor binding
SUTH_00213	COG3383	formate dehydrogenase (NAD+) activity
SUTH_00214	COG0243	molybdopterin cofactor binding
SUTH_00214	COG3383	formate dehydrogenase (NAD+) activity
SUTH_00216	COG4191	Histidine kinase
SUTH_00217	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SUTH_00218	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SUTH_00227	COG0708	Exodeoxyribonuclease III
SUTH_00228	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SUTH_00230	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SUTH_00231	COG0154	amidase activity
SUTH_00232	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SUTH_00233	COG1077	Cell shape determining protein MreB Mrl
SUTH_00236	COG0768	penicillin binding
SUTH_00237	COG0772	Belongs to the SEDS family
SUTH_00239	COG1686	Belongs to the peptidase S11 family
SUTH_00240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SUTH_00241	COG2921	Belongs to the UPF0250 family
SUTH_00242	COG0321	lipoyl(octanoyl) transferase activity
SUTH_00243	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SUTH_00250	COG0318	PFAM AMP-dependent synthetase and ligase
SUTH_00253	COG0210	DNA helicase
SUTH_00254	COG3245	cytochrome
SUTH_00256	COG0415	Belongs to the DNA photolyase family
SUTH_00257	COG1678	Uncharacterized ACR, COG1678
SUTH_00258	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SUTH_00260	COG0540	Belongs to the ATCase OTCase family
SUTH_00262	COG0513	Belongs to the DEAD box helicase family
SUTH_00263	COG1872	DUF167
SUTH_00264	COG0762	integral membrane protein
SUTH_00269	COG0840	transmembrane signaling receptor activity
SUTH_00269	COG3290	protein histidine kinase activity
SUTH_00276	COG0411	ABC transporter
SUTH_00281	COG1331	Highly conserved protein containing a thioredoxin domain
SUTH_00282	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
SUTH_00283	COG0745	RESPONSE REGULATOR receiver
SUTH_00291	COG0129	dihydroxy-acid dehydratase activity
SUTH_00293	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SUTH_00294	COG0300	oxidoreductase activity
SUTH_00297	COG0018	arginyl-trna synthetase
SUTH_00298	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SUTH_00304	COG2945	thiolester hydrolase activity
SUTH_00307	COG4680	protein conserved in bacteria
SUTH_00311	COG2022	thiamine diphosphate biosynthetic process
SUTH_00313	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SUTH_00314	COG3706	GGDEF domain
SUTH_00316	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SUTH_00317	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SUTH_00318	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SUTH_00319	COG0631	protein serine/threonine phosphatase activity
SUTH_00320	COG0515	serine threonine protein kinase
SUTH_00321	COG1561	YicC-like family, N-terminal region
SUTH_00323	COG0840	transmembrane signaling receptor activity
SUTH_00324	COG0835	chemotaxis
SUTH_00326	COG0788	formyltetrahydrofolate deformylase activity
SUTH_00329	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SUTH_00330	COG2937	Belongs to the GPAT DAPAT family
SUTH_00331	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SUTH_00332	COG2890	protein-(glutamine-N5) methyltransferase activity
SUTH_00333	COG2703	oxygen carrier activity
SUTH_00335	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SUTH_00337	COG1309	transcriptional regulator
SUTH_00338	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SUTH_00343	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SUTH_00346	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SUTH_00348	COG4536	flavin adenine dinucleotide binding
SUTH_00350	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SUTH_00351	COG0741	lytic transglycosylase activity
SUTH_00352	COG0442	prolyl-tRNA aminoacylation
SUTH_00353	COG0494	nUDIX hydrolase
SUTH_00355	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
SUTH_00356	COG1765	OsmC-like protein
SUTH_00362	COG4133	protoheme IX ABC transporter activity
SUTH_00363	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SUTH_00366	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
SUTH_00368	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SUTH_00372	COG0243	molybdopterin cofactor binding
SUTH_00373	COG0437	4 iron, 4 sulfur cluster binding
SUTH_00374	COG0348	domain, Protein
SUTH_00376	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SUTH_00378	COG1230	cation diffusion facilitator family transporter
SUTH_00380	COG1309	transcriptional regulator
SUTH_00384	COG0577	efflux transmembrane transporter activity
SUTH_00384	COG1136	(ABC) transporter
SUTH_00388	COG0798	PFAM Bile acid sodium symporter
SUTH_00395	COG2897	thiosulfate sulfurtransferase activity
SUTH_00397	COG0183	Belongs to the thiolase family
SUTH_00399	COG0183	Belongs to the thiolase family
SUTH_00404	COG0183	Belongs to the thiolase family
SUTH_00409	COG2391	methyltransferase activity
SUTH_00426	COG0243	molybdopterin cofactor binding
SUTH_00430	COG3852	Histidine kinase
SUTH_00431	COG2204	response regulator
SUTH_00432	COG2226	methyltransferase
SUTH_00435	COG3852	Histidine kinase
SUTH_00437	COG0243	molybdopterin cofactor binding
SUTH_00438	COG0437	4 iron, 4 sulfur cluster binding
SUTH_00440	COG2226	methyltransferase
SUTH_00444	COG4191	Histidine kinase
SUTH_00445	COG2204	response regulator
SUTH_00451	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SUTH_00452	COG1758	RNA polymerase activity
SUTH_00453	COG0194	GDP metabolic process
SUTH_00470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SUTH_00471	COG0606	chelatase, subunit chli
SUTH_00479	COG3385	transposase activity
SUTH_00493	COG0745	RESPONSE REGULATOR receiver
SUTH_00497	COG1136	(ABC) transporter
SUTH_00497	COG0577	efflux transmembrane transporter activity
SUTH_00498	COG1136	(ABC) transporter
SUTH_00498	COG0577	efflux transmembrane transporter activity
SUTH_00502	COG1846	Transcriptional regulator
SUTH_00506	COG3119	arylsulfatase activity
SUTH_00507	COG0318	PFAM AMP-dependent synthetase and ligase
SUTH_00511	COG0583	DNA-binding transcription factor activity
SUTH_00513	COG2271	Major facilitator Superfamily
SUTH_00515	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
SUTH_00515	COG0028	Belongs to the TPP enzyme family
SUTH_00517	COG0641	radical SAM
SUTH_00522	COG0606	chelatase, subunit chli
SUTH_00523	COG2960	long-chain fatty acid transporting porin activity
SUTH_00526	COG0004	ammonium transporteR
SUTH_00527	COG0840	transmembrane signaling receptor activity
SUTH_00529	COG3243	poly(R)-hydroxyalkanoic acid synthase
SUTH_00531	COG0789	Transcriptional regulator
SUTH_00533	COG1960	acyl-CoA dehydrogenase activity
SUTH_00536	COG0288	reversible hydration of carbon dioxide
SUTH_00537	COG0183	Belongs to the thiolase family
SUTH_00538	COG1024	Enoyl-CoA hydratase
SUTH_00539	COG1960	acyl-CoA dehydrogenase activity
SUTH_00543	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SUTH_00544	COG1024	Enoyl-CoA hydratase
SUTH_00548	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SUTH_00550	COG1660	Displays ATPase and GTPase activities
SUTH_00554	COG1194	a g-specific adenine glycosylase
SUTH_00555	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SUTH_00556	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SUTH_00564	COG0583	DNA-binding transcription factor activity
SUTH_00565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SUTH_00573	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SUTH_00574	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SUTH_00578	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SUTH_00582	COG0019	diaminopimelate decarboxylase activity
SUTH_00583	COG1965	Belongs to the frataxin family
SUTH_00585	COG0443	Heat shock 70 kDa protein
SUTH_00590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SUTH_00591	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SUTH_00592	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SUTH_00593	COG0069	glutamate synthase activity
SUTH_00593	COG0067	glutamate synthase
SUTH_00593	COG0070	glutamate synthase
SUTH_00595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SUTH_00596	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SUTH_00598	COG2832	Protein of unknown function (DUF454)
SUTH_00599	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SUTH_00611	COG2205	protein histidine kinase activity
SUTH_00615	COG2205	protein histidine kinase activity
SUTH_00616	COG2197	response regulator
SUTH_00621	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SUTH_00621	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SUTH_00621	COG1703	isobutyryl-CoA mutase activity
SUTH_00623	COG1250	3-hydroxyacyl-CoA dehydrogenase
SUTH_00625	COG1022	Amp-dependent synthetase and ligase
SUTH_00632	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SUTH_00639	COG0277	FAD linked oxidase domain protein
SUTH_00643	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SUTH_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SUTH_00647	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SUTH_00648	COG0081	regulation of translation
SUTH_00649	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SUTH_00650	COG0222	ribosome binding
SUTH_00651	COG0085	RNA polymerase activity
SUTH_00652	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SUTH_00653	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SUTH_00654	COG0049	tRNA binding
SUTH_00655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SUTH_00656	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SUTH_00657	COG0051	transcription antitermination factor activity, RNA binding
SUTH_00658	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SUTH_00659	COG0088	Forms part of the polypeptide exit tunnel
SUTH_00660	COG0089	rRNA binding
SUTH_00661	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SUTH_00662	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SUTH_00663	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SUTH_00664	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SUTH_00665	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SUTH_00666	COG0255	Belongs to the universal ribosomal protein uL29 family
SUTH_00667	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SUTH_00668	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SUTH_00669	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SUTH_00670	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SUTH_00671	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SUTH_00672	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SUTH_00673	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SUTH_00674	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SUTH_00675	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SUTH_00676	COG1841	ribosomal large subunit assembly
SUTH_00677	COG0200	Binds to the 23S rRNA
SUTH_00678	COG0201	protein transport
SUTH_00679	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SUTH_00680	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SUTH_00681	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SUTH_00682	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SUTH_00683	COG0202	RNA polymerase activity
SUTH_00684	COG0203	ribosomal protein L17
SUTH_00685	COG2895	sulfate adenylyltransferase (ATP) activity
SUTH_00687	COG0175	sulfate reduction
SUTH_00689	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SUTH_00690	COG0730	response to heat
SUTH_00691	COG0583	DNA-binding transcription factor activity
SUTH_00693	COG3028	Belongs to the UPF0307 family
SUTH_00694	COG0312	modulator of DNA gyrase
SUTH_00699	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SUTH_00700	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SUTH_00702	COG2186	Transcriptional regulator
SUTH_00703	COG0406	alpha-ribazole phosphatase activity
SUTH_00704	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SUTH_00705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SUTH_00706	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SUTH_00706	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SUTH_00708	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SUTH_00710	COG0793	Belongs to the peptidase S41A family
SUTH_00712	COG0588	phosphoglycerate mutase activity
SUTH_00713	COG0640	Transcriptional regulator
SUTH_00714	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SUTH_00716	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SUTH_00718	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SUTH_00719	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SUTH_00720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SUTH_00721	COG1459	type II secretion system
SUTH_00731	COG3267	Type II secretory pathway component ExeA
SUTH_00731	COG3409	Peptidoglycan-binding domain 1 protein
SUTH_00734	COG1040	competence protein
SUTH_00735	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SUTH_00736	COG2226	methyltransferase
SUTH_00738	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SUTH_00739	COG0508	dehydrogenase complex catalyzes the overall conversion of
SUTH_00741	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SUTH_00742	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SUTH_00744	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
SUTH_00746	COG0583	DNA-binding transcription factor activity
SUTH_00747	COG1741	Belongs to the pirin family
SUTH_00749	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SUTH_00749	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SUTH_00751	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SUTH_00756	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SUTH_00757	COG1850	ribulose-bisphosphate carboxylase activity
SUTH_00761	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SUTH_00762	COG3954	Phosphoribulokinase
SUTH_00763	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SUTH_00764	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SUTH_00765	COG0126	phosphoglycerate kinase activity
SUTH_00766	COG0469	pyruvate kinase activity
SUTH_00769	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SUTH_00771	COG0339	signal peptide processing
SUTH_00774	COG0708	Exodeoxyribonuclease III
SUTH_00779	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SUTH_00780	COG0121	glutamine amidotransferase
SUTH_00781	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SUTH_00782	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SUTH_00783	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SUTH_00785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SUTH_00786	COG0006	proline dipeptidase activity
SUTH_00787	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SUTH_00790	COG0138	bifunctional purine biosynthesis protein purh
SUTH_00791	COG0151	Belongs to the GarS family
SUTH_00792	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SUTH_00793	COG0009	L-threonylcarbamoyladenylate synthase
SUTH_00800	COG0584	glycerophosphoryl diester phosphodiesterase
SUTH_00802	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SUTH_00804	COG3549	Plasmid maintenance system killer
SUTH_00810	COG0429	hydrolase of the alpha beta-hydrolase fold
SUTH_00812	COG0859	PFAM glycosyl transferase family 9
SUTH_00816	COG0482	sulfurtransferase activity
SUTH_00821	COG0802	atpase or kinase
SUTH_00822	COG0860	N-Acetylmuramoyl-L-alanine amidase
SUTH_00823	COG0196	riboflavin kinase activity
SUTH_00825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SUTH_00826	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SUTH_00827	COG1047	Peptidyl-prolyl cis-trans
SUTH_00828	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SUTH_00835	COG2217	Heavy metal translocating P-type atpase
SUTH_00837	COG3278	Belongs to the heme-copper respiratory oxidase family
SUTH_00853	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SUTH_00854	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SUTH_00857	COG2217	Heavy metal translocating P-type atpase
SUTH_00858	COG2608	mercury ion transmembrane transporter activity
SUTH_00859	COG0783	Belongs to the Dps family
SUTH_00861	COG0450	alkyl hydroperoxide reductase
SUTH_00869	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SUTH_00870	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SUTH_00870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SUTH_00872	COG2840	Smr protein MutS2
SUTH_00873	COG0492	ferredoxin-NADP+ reductase activity
SUTH_00878	COG1674	ftsk spoiiie
SUTH_00879	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
SUTH_00880	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SUTH_00881	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SUTH_00882	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
SUTH_00884	COG1032	radical SAM domain protein
SUTH_00887	COG2816	NAD+ diphosphatase activity
SUTH_00890	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SUTH_00891	COG1360	Flagellar Motor Protein
SUTH_00895	COG0835	chemotaxis
SUTH_00896	COG0840	transmembrane signaling receptor activity
SUTH_00896	COG0840	transmembrane signaling receptor activity
SUTH_00898	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SUTH_00899	COG2201	protein-glutamate methylesterase activity
SUTH_00901	COG2203	Gaf domain
SUTH_00901	COG0840	transmembrane signaling receptor activity
SUTH_00902	COG0835	chemotaxis
SUTH_00902	COG0784	Response regulator, receiver
SUTH_00903	COG0835	chemotaxis
SUTH_00903	COG0784	Response regulator, receiver
SUTH_00904	COG0745	RESPONSE REGULATOR receiver
SUTH_00905	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
SUTH_00906	COG0643	Histidine kinase
SUTH_00906	COG2198	Histidine kinase
SUTH_00907	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SUTH_00908	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SUTH_00916	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
SUTH_00918	COG1558	bacterial-type flagellum-dependent cell motility
SUTH_00919	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SUTH_00920	COG1749	Flagellar hook protein flgE
SUTH_00921	COG4787	bacterial-type flagellum-dependent cell motility
SUTH_00922	COG1749	Flagellar hook protein flgE
SUTH_00923	COG4786	Flagellar basal body rod
SUTH_00924	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SUTH_00925	COG1706	bacterial-type flagellum-dependent cell motility
SUTH_00926	COG3951	Flagellar rod assembly protein muramidase FlgJ
SUTH_00926	COG1705	Flagellar rod assembly protein muramidase FlgJ
SUTH_00927	COG1256	bacterial-type flagellum assembly
SUTH_00928	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SUTH_00931	COG1987	bacterial-type flagellum assembly
SUTH_00932	COG1338	Plays a role in the flagellum-specific transport system
SUTH_00939	COG1157	protein secretion by the type III secretion system
SUTH_00941	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SUTH_00943	COG4191	Histidine kinase
SUTH_00945	COG1677	Flagellar hook-basal body complex protein FliE
SUTH_00953	COG0438	transferase activity, transferring glycosyl groups
SUTH_00956	COG0500	methyltransferase
SUTH_00958	COG2974	May be involved in recombination
SUTH_00960	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
SUTH_00965	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SUTH_00970	COG2271	Major facilitator Superfamily
SUTH_00972	COG1612	heme a metabolic process
SUTH_00973	COG0315	cyclic pyranopterin monophosphate synthase activity
SUTH_00974	COG4783	chaperone-mediated protein folding
SUTH_00978	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SUTH_00979	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
SUTH_00981	COG0348	domain, Protein
SUTH_00987	COG1959	2 iron, 2 sulfur cluster binding
SUTH_00991	COG2920	part of a sulfur-relay system
SUTH_00997	COG1028	Short-chain dehydrogenase reductase Sdr
SUTH_01001	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SUTH_01002	COG3707	response regulator
SUTH_01003	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SUTH_01005	COG1116	anion transmembrane transporter activity
SUTH_01006	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SUTH_01008	COG0243	molybdopterin cofactor binding
SUTH_01009	COG0243	molybdopterin cofactor binding
SUTH_01010	COG1716	ATPase activity
SUTH_01011	COG0515	serine threonine protein kinase
SUTH_01011	COG2815	serine threonine protein kinase
SUTH_01012	COG0326	Molecular chaperone. Has ATPase activity
SUTH_01014	COG0058	SHG alpha-glucan phosphorylase activity
SUTH_01022	COG0179	Fumarylacetoacetate (FAA) hydrolase
SUTH_01025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SUTH_01032	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SUTH_01034	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SUTH_01035	COG4660	Part of a membrane complex involved in electron transport
SUTH_01036	COG4659	FMN binding
SUTH_01037	COG4658	electron transport chain
SUTH_01039	COG2878	Part of a membrane complex involved in electron transport
SUTH_01040	COG4657	Part of a membrane complex involved in electron transport
SUTH_01041	COG0167	dihydroorotate dehydrogenase activity
SUTH_01047	COG0825	malonyl-CoA metabolic process
SUTH_01049	COG0037	tRNA processing
SUTH_01056	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SUTH_01059	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SUTH_01060	COG0124	histidyl-tRNA synthetase
SUTH_01063	COG1160	GTP binding
SUTH_01064	COG1923	regulation of RNA biosynthetic process
SUTH_01065	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SUTH_01066	COG0330	HflC and HflK could
SUTH_01067	COG0330	HflC and HflK could
SUTH_01069	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SUTH_01070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SUTH_01072	COG0557	exoribonuclease II activity
SUTH_01073	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SUTH_01074	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SUTH_01075	COG2003	Belongs to the UPF0758 family
SUTH_01076	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SUTH_01077	COG0756	dUTP diphosphatase activity
SUTH_01079	COG0446	pyridine nucleotide-disulphide oxidoreductase
SUTH_01081	COG3005	denitrification pathway
SUTH_01082	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SUTH_01083	COG0583	DNA-binding transcription factor activity
SUTH_01084	COG1073	alpha beta
SUTH_01086	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SUTH_01087	COG0542	response to heat
SUTH_01088	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SUTH_01089	COG1278	Cold shock
SUTH_01090	COG0538	isocitrate dehydrogenase activity
SUTH_01091	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
SUTH_01092	COG1187	pseudouridine synthase activity
SUTH_01095	COG2900	Belongs to the SlyX family
SUTH_01096	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SUTH_01097	COG1570	exodeoxyribonuclease VII activity
SUTH_01100	COG0811	peptide transport
SUTH_01101	COG0848	biopolymer transport protein
SUTH_01102	COG1663	tetraacyldisaccharide 4'-kinase activity
SUTH_01103	COG2835	tetraacyldisaccharide 4'-kinase activity
SUTH_01104	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SUTH_01105	COG0563	adenylate kinase activity
SUTH_01106	COG0205	6-phosphofructokinase activity
SUTH_01107	COG0205	6-phosphofructokinase activity
SUTH_01108	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SUTH_01109	COG0405	Gamma-glutamyltransferase
SUTH_01110	COG0728	peptidoglycan biosynthetic process
SUTH_01112	COG1192	Involved in chromosome partitioning
SUTH_01113	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SUTH_01114	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SUTH_01115	COG0137	argininosuccinate synthase activity
SUTH_01117	COG3123	guanosine phosphorylase activity
SUTH_01118	COG1666	GTP binding
SUTH_01119	COG0505	Belongs to the CarA family
SUTH_01122	COG0183	Belongs to the thiolase family
SUTH_01123	COG0840	transmembrane signaling receptor activity
SUTH_01124	COG2963	transposase activity
SUTH_01126	COG0318	PFAM AMP-dependent synthetase and ligase
SUTH_01129	COG2130	NADP-dependent
SUTH_01131	COG3039	Transposase
SUTH_01133	COG0183	Belongs to the thiolase family
SUTH_01134	COG1024	Enoyl-CoA hydratase
SUTH_01134	COG1250	3-hydroxyacyl-CoA dehydrogenase
SUTH_01135	COG0410	ABC transporter
SUTH_01138	COG0559	Belongs to the binding-protein-dependent transport system permease family
SUTH_01141	COG1597	lipid kinase activity
SUTH_01147	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SUTH_01150	COG1858	cytochrome C peroxidase
SUTH_01152	COG0745	RESPONSE REGULATOR receiver
SUTH_01153	COG2205	protein histidine kinase activity
SUTH_01154	COG1671	Belongs to the UPF0178 family
SUTH_01158	COG1999	signal sequence binding
SUTH_01160	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SUTH_01163	COG4172	Belongs to the ABC transporter superfamily
SUTH_01164	COG4239	(ABC) transporter, permease
SUTH_01165	COG4174	ABC transporter (Permease)
SUTH_01166	COG4166	transmembrane transport
SUTH_01167	COG1388	LysM domain
SUTH_01167	COG0741	lytic transglycosylase activity
SUTH_01169	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SUTH_01170	COG2226	methyltransferase
SUTH_01171	COG0328	RNA-DNA hybrid ribonuclease activity
SUTH_01172	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SUTH_01185	COG0826	peptidase U32
SUTH_01194	COG0488	(ABC) transporter
SUTH_01204	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SUTH_01204	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SUTH_01205	COG0509	glycine decarboxylation via glycine cleavage system
SUTH_01206	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SUTH_01209	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SUTH_01214	COG3706	GGDEF domain
SUTH_01214	COG0745	RESPONSE REGULATOR receiver
SUTH_01218	COG1595	DNA-templated transcription, initiation
SUTH_01219	COG2259	Doxx family
SUTH_01221	COG3220	belongs to the UPF0276 family
SUTH_01228	COG0411	ABC transporter
SUTH_01231	COG0318	PFAM AMP-dependent synthetase and ligase
SUTH_01232	COG1024	Enoyl-CoA hydratase
SUTH_01234	COG1960	acyl-CoA dehydrogenase activity
SUTH_01235	COG0583	DNA-binding transcription factor activity
SUTH_01237	COG2159	amidohydrolase
SUTH_01244	COG0667	Aldo Keto reductase
SUTH_01252	COG3039	Transposase
SUTH_01257	COG2197	response regulator
SUTH_01259	COG3706	GGDEF domain
SUTH_01259	COG0745	RESPONSE REGULATOR receiver
SUTH_01263	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SUTH_01264	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
SUTH_01266	COG0395	ABC-type sugar transport system, permease component
SUTH_01267	COG1175	transmembrane transport
SUTH_01269	COG0281	malic enzyme
SUTH_01278	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
SUTH_01283	COG1162	GTPase activity
SUTH_01284	COG2154	pterin-4-alpha-carbinolamine dehydratase
SUTH_01285	COG0501	Belongs to the peptidase M48B family
SUTH_01286	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SUTH_01288	COG0254	rRNA binding
SUTH_01289	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SUTH_01291	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SUTH_01292	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SUTH_01294	COG2814	Major facilitator Superfamily
SUTH_01295	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SUTH_01297	COG0066	3-isopropylmalate dehydratase activity
SUTH_01298	COG0473	3-isopropylmalate dehydrogenase activity
SUTH_01302	COG0101	tRNA pseudouridine synthase activity
SUTH_01303	COG0135	phosphoribosylanthranilate isomerase activity
SUTH_01304	COG0133	tryptophan synthase activity
SUTH_01305	COG0159	tryptophan synthase activity
SUTH_01306	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SUTH_01307	COG0285	dihydrofolate synthase activity
SUTH_01309	COG1286	toxin biosynthetic process
SUTH_01312	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SUTH_01317	COG0215	cysteine-tRNA ligase activity
SUTH_01319	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SUTH_01324	COG0484	heat shock protein binding
SUTH_01325	COG0443	Heat shock 70 kDa protein
SUTH_01326	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SUTH_01327	COG0840	transmembrane signaling receptor activity
SUTH_01331	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SUTH_01332	COG1420	regulation of RNA biosynthetic process
SUTH_01333	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SUTH_01334	COG0497	DNA recombination
SUTH_01335	COG2119	membrane
SUTH_01336	COG0735	belongs to the Fur family
SUTH_01337	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SUTH_01338	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SUTH_01339	COG0505	Belongs to the CarA family
SUTH_01341	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SUTH_01342	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SUTH_01345	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SUTH_01346	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SUTH_01348	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SUTH_01349	COG3300	MHYT domain
SUTH_01349	COG5001	Diguanylate cyclase
SUTH_01355	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SUTH_01358	COG0438	transferase activity, transferring glycosyl groups
SUTH_01361	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SUTH_01362	COG0573	inorganic phosphate transmembrane transporter activity
SUTH_01364	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SUTH_01365	COG1858	cytochrome C peroxidase
SUTH_01373	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SUTH_01374	COG1053	succinate dehydrogenase
SUTH_01375	COG0149	triose-phosphate isomerase activity
SUTH_01378	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SUTH_01379	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SUTH_01381	COG0649	NAD binding
SUTH_01382	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SUTH_01385	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SUTH_01386	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SUTH_01388	COG0713	ATP synthesis coupled electron transport
SUTH_01391	COG1007	ATP synthesis coupled electron transport
SUTH_01392	COG0494	nUDIX hydrolase
SUTH_01393	COG3850	Histidine kinase
SUTH_01394	COG2197	response regulator
SUTH_01403	COG3039	Transposase
SUTH_01405	COG3093	addiction module antidote protein HigA
SUTH_01406	COG3549	Plasmid maintenance system killer
SUTH_01412	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SUTH_01415	COG2267	carboxylic ester hydrolase activity
SUTH_01417	COG2878	Part of a membrane complex involved in electron transport
SUTH_01417	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
SUTH_01418	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SUTH_01418	COG1013	pyruvate-flavodoxin oxidoreductase activity
SUTH_01418	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SUTH_01418	COG0674	pyruvate-flavodoxin oxidoreductase activity
SUTH_01419	COG4656	Part of a membrane complex involved in electron transport
SUTH_01420	COG4658	electron transport chain
SUTH_01422	COG4660	Part of a membrane complex involved in electron transport
SUTH_01423	COG4657	Part of a membrane complex involved in electron transport
SUTH_01425	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SUTH_01428	COG0686	Belongs to the AlaDH PNT family
SUTH_01429	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SUTH_01430	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SUTH_01430	COG1648	precorrin-2 dehydrogenase activity
SUTH_01432	COG1797	cobyrinic acid a,c-diamide synthase activity
SUTH_01439	COG2920	part of a sulfur-relay system
SUTH_01440	COG2168	tRNA wobble position uridine thiolation
SUTH_01441	COG2923	Belongs to the DsrF TusC family
SUTH_01442	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
SUTH_01443	COG2221	Nitrite and sulphite reductase 4Fe-4S
SUTH_01444	COG2221	Nitrite and sulphite reductase 4Fe-4S
SUTH_01447	COG0425	Belongs to the sulfur carrier protein TusA family
SUTH_01452	COG1234	tRNA 3'-trailer cleavage
SUTH_01453	COG0493	'glutamate synthase
SUTH_01454	COG3327	negative regulation of DNA-templated transcription, initiation
SUTH_01458	COG3039	Transposase
SUTH_01459	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SUTH_01460	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SUTH_01463	COG3706	GGDEF domain
SUTH_01465	COG2204	response regulator
SUTH_01467	COG2205	protein histidine kinase activity
SUTH_01468	COG0492	ferredoxin-NADP+ reductase activity
SUTH_01478	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SUTH_01482	COG1960	acyl-CoA dehydrogenase activity
SUTH_01483	COG1250	3-hydroxyacyl-CoA dehydrogenase
SUTH_01483	COG1024	Enoyl-CoA hydratase
SUTH_01484	COG0183	Belongs to the thiolase family
SUTH_01488	COG1960	acyl-CoA dehydrogenase activity
SUTH_01492	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SUTH_01493	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SUTH_01494	COG1187	pseudouridine synthase activity
SUTH_01496	COG0360	Binds together with S18 to 16S ribosomal RNA
SUTH_01497	COG2965	DNA replication, synthesis of RNA primer
SUTH_01498	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SUTH_01499	COG0359	binds to the 23S rRNA
SUTH_01500	COG0305	Participates in initiation and elongation during chromosome replication
SUTH_01501	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SUTH_01502	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SUTH_01503	COG0726	polysaccharide deacetylase
SUTH_01505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SUTH_01505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SUTH_01506	COG0463	Glycosyl transferase, family 2
SUTH_01507	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SUTH_01508	COG2076	Multidrug Resistance protein
SUTH_01509	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SUTH_01511	COG0436	Aminotransferase
SUTH_01526	COG1960	acyl-CoA dehydrogenase activity
SUTH_01529	COG0613	PHP domain protein
SUTH_01530	COG0009	L-threonylcarbamoyladenylate synthase
SUTH_01531	COG1994	Peptidase M50
SUTH_01532	COG0180	Tryptophanyl-tRNA synthetase
SUTH_01534	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SUTH_01536	COG0779	Required for maturation of 30S ribosomal subunits
SUTH_01537	COG0195	Participates in both transcription termination and antitermination
SUTH_01538	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SUTH_01539	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SUTH_01540	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SUTH_01541	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SUTH_01542	COG1185	polyribonucleotide nucleotidyltransferase activity
SUTH_01543	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SUTH_01545	COG1403	HNH endonuclease
SUTH_01552	COG0069	glutamate synthase activity
SUTH_01554	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SUTH_01554	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SUTH_01556	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SUTH_01557	COG1473	amidohydrolase
SUTH_01559	COG0861	Integral membrane protein TerC family
SUTH_01560	COG0671	phosphoesterase, PA-phosphatase related
SUTH_01562	COG0583	DNA-binding transcription factor activity
SUTH_01566	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SUTH_01568	COG1573	uracil-dna glycosylase
SUTH_01569	COG0322	excinuclease ABC activity
SUTH_01574	COG0582	viral genome integration into host DNA
SUTH_01578	COG3093	addiction module antidote protein HigA
SUTH_01582	COG3311	Transcriptional regulator
SUTH_01584	COG1802	Transcriptional regulator
SUTH_01584	COG4626	Terminase
SUTH_01585	COG0305	Participates in initiation and elongation during chromosome replication
SUTH_01598	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SUTH_01601	COG1045	serine acetyltransferase
SUTH_01603	COG1104	cysteine desulfurase activity
SUTH_01604	COG1104	cysteine desulfurase activity
SUTH_01605	COG0822	iron-sulfur transferase activity
SUTH_01607	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SUTH_01608	COG0443	Heat shock 70 kDa protein
SUTH_01611	COG0084	hydrolase, TatD family'
SUTH_01615	COG0242	peptide deformylase activity
SUTH_01617	COG3706	GGDEF domain
SUTH_01621	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SUTH_01622	COG0243	molybdopterin cofactor binding
SUTH_01631	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SUTH_01637	COG4680	protein conserved in bacteria
SUTH_01654	COG1024	Enoyl-CoA hydratase
SUTH_01656	COG1024	Enoyl-CoA hydratase
SUTH_01657	COG1028	Short-chain dehydrogenase reductase Sdr
SUTH_01658	COG1960	acyl-CoA dehydrogenase activity
SUTH_01663	COG0411	ABC transporter
SUTH_01667	COG3360	Dodecin
SUTH_01670	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SUTH_01672	COG3787	Belongs to the UPF0306 family
SUTH_01682	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SUTH_01684	COG2171	N-acyltransferase activity
SUTH_01689	COG4681	YaeQ
SUTH_01699	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SUTH_01701	COG2824	Alkylphosphonate utilization operon protein PhnA
SUTH_01707	COG0556	nucleotide-excision repair
SUTH_01708	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SUTH_01709	COG1530	ribonuclease E activity
SUTH_01710	COG0564	pseudouridine synthase activity
SUTH_01711	COG0546	phosphoglycolate phosphatase activity
SUTH_01713	COG0616	signal peptide processing
SUTH_01713	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SUTH_01714	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SUTH_01716	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SUTH_01717	COG1127	ABC transporter
SUTH_01720	COG0318	PFAM AMP-dependent synthetase and ligase
SUTH_01722	COG1024	Enoyl-CoA hydratase
SUTH_01723	COG0318	PFAM AMP-dependent synthetase and ligase
SUTH_01724	COG2270	Major facilitator Superfamily
SUTH_01729	COG0559	Belongs to the binding-protein-dependent transport system permease family
SUTH_01731	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SUTH_01732	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SUTH_01733	COG0583	DNA-binding transcription factor activity
SUTH_01735	COG3437	response regulator, receiver
SUTH_01735	COG0784	Response regulator, receiver
SUTH_01738	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SUTH_01739	COG1196	nuclear chromosome segregation
SUTH_01741	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SUTH_01742	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SUTH_01748	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SUTH_01749	COG3706	GGDEF domain
SUTH_01750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SUTH_01752	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SUTH_01753	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SUTH_01754	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
SUTH_01758	COG0598	Magnesium transport protein CorA
SUTH_01761	COG2205	protein histidine kinase activity
SUTH_01762	COG0745	RESPONSE REGULATOR receiver
SUTH_01763	COG3158	transport of potassium into the cell
SUTH_01771	COG1355	regulation of microtubule-based process
SUTH_01774	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SUTH_01775	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SUTH_01779	COG3039	Transposase
SUTH_01781	COG2205	protein histidine kinase activity
SUTH_01782	COG0745	RESPONSE REGULATOR receiver
SUTH_01787	COG0071	Belongs to the small heat shock protein (HSP20) family
SUTH_01794	COG1595	DNA-templated transcription, initiation
SUTH_01798	COG0039	L-malate dehydrogenase activity
SUTH_01801	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
SUTH_01802	COG1053	succinate dehydrogenase
SUTH_01803	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SUTH_01804	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
SUTH_01806	COG0567	Dehydrogenase, E1 component
SUTH_01807	COG0508	dehydrogenase complex catalyzes the overall conversion of
SUTH_01808	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SUTH_01809	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SUTH_01813	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SUTH_01814	COG2274	protein secretion by the type I secretion system
SUTH_01815	COG1598	PFAM Uncharacterised protein family UPF0150
SUTH_01822	COG1132	(ABC) transporter
SUTH_01824	COG5002	protein histidine kinase activity
SUTH_01830	COG0745	RESPONSE REGULATOR receiver
SUTH_01831	COG5002	protein histidine kinase activity
SUTH_01833	COG2205	protein histidine kinase activity
SUTH_01833	COG2202	Pas domain
SUTH_01834	COG5002	protein histidine kinase activity
SUTH_01836	COG5001	Diguanylate cyclase
SUTH_01836	COG3300	MHYT domain
SUTH_01837	COG0745	RESPONSE REGULATOR receiver
SUTH_01847	COG1132	(ABC) transporter
SUTH_01849	COG0084	hydrolase, TatD family'
SUTH_01850	COG0470	DNA polymerase III
SUTH_01851	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SUTH_01852	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SUTH_01856	COG0590	tRNA wobble adenosine to inosine editing
SUTH_01857	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SUTH_01857	COG0574	Belongs to the PEP-utilizing enzyme family
SUTH_01859	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SUTH_01862	COG3550	peptidyl-serine autophosphorylation
SUTH_01873	COG2135	peptidase activity
SUTH_01876	COG0358	DNA primase activity
SUTH_01879	COG1401	restriction endodeoxyribonuclease activity
SUTH_01886	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
SUTH_01887	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SUTH_01888	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SUTH_01902	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SUTH_01908	COG3047	cAMP biosynthetic process
SUTH_01908	COG2885	chlorophyll binding
SUTH_01912	COG0210	DNA helicase
SUTH_01917	COG0210	DNA helicase
SUTH_01921	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SUTH_01937	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SUTH_01939	COG0732	type I restriction modification DNA specificity domain
SUTH_01940	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SUTH_01942	COG2003	Belongs to the UPF0758 family
SUTH_01955	COG1475	DNA binding
SUTH_01958	COG3723	Recombinational DNA repair protein, rece pathway
SUTH_01962	COG0629	single-stranded DNA binding
SUTH_01966	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SUTH_01969	COG0582	viral genome integration into host DNA
SUTH_01970	COG0519	Catalyzes the synthesis of GMP from XMP
SUTH_01970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SUTH_01972	COG2914	Belongs to the UPF0125 (RnfH) family
SUTH_01973	COG2867	negative regulation of translational initiation
SUTH_01974	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SUTH_01975	COG2814	Major facilitator Superfamily
SUTH_01979	COG2070	2-Nitropropane dioxygenase
SUTH_01981	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SUTH_01982	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SUTH_01984	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
SUTH_01986	COG0776	regulation of translation
SUTH_01988	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SUTH_01989	COG0287	Prephenate dehydrogenase
SUTH_01990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SUTH_01992	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SUTH_01993	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SUTH_01995	COG0402	S-adenosylhomocysteine deaminase activity
SUTH_01997	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SUTH_02002	COG2197	response regulator
SUTH_02003	COG0745	RESPONSE REGULATOR receiver
SUTH_02003	COG3706	GGDEF domain
SUTH_02004	COG2239	Acts as a magnesium transporter
SUTH_02005	COG0515	serine threonine protein kinase
SUTH_02005	COG2815	serine threonine protein kinase
SUTH_02008	COG2267	carboxylic ester hydrolase activity
SUTH_02010	COG2814	Major facilitator Superfamily
SUTH_02013	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SUTH_02014	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SUTH_02019	COG2204	response regulator
SUTH_02020	COG1024	Enoyl-CoA hydratase
SUTH_02020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SUTH_02021	COG0309	Hydrogenase expression formation protein (HypE)
SUTH_02022	COG0409	Hydrogenase expression formation protein
SUTH_02023	COG0298	carbon dioxide binding
SUTH_02024	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SUTH_02026	COG0375	protein maturation
SUTH_02029	COG0298	carbon dioxide binding
SUTH_02030	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SUTH_02031	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SUTH_02032	COG5557	Pfam Polysulphide reductase, NrfD
SUTH_02033	COG0437	4 iron, 4 sulfur cluster binding
SUTH_02034	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
SUTH_02040	COG4628	conserved protein (DUF2132)
SUTH_02042	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SUTH_02046	COG0864	Transcriptional regulator
SUTH_02048	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SUTH_02049	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SUTH_02050	COG3383	formate dehydrogenase (NAD+) activity
SUTH_02051	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
SUTH_02052	COG3259	Nickel-dependent hydrogenase
SUTH_02054	COG3387	PFAM Glycoside hydrolase 15-related
SUTH_02056	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SUTH_02059	COG4566	intracellular signal transduction
SUTH_02064	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SUTH_02065	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SUTH_02067	COG0625	glutathione transferase activity
SUTH_02073	COG1024	Enoyl-CoA hydratase
SUTH_02074	COG1022	Amp-dependent synthetase and ligase
SUTH_02075	COG0410	ABC transporter
SUTH_02078	COG0559	Belongs to the binding-protein-dependent transport system permease family
SUTH_02081	COG1028	Short-chain dehydrogenase reductase Sdr
SUTH_02083	COG0385	Bile acid
SUTH_02086	COG1414	Transcriptional regulator
SUTH_02089	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SUTH_02090	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SUTH_02093	COG2199	diguanylate cyclase activity
SUTH_02093	COG2202	Pas domain
SUTH_02093	COG2200	EAL domain
SUTH_02097	COG4999	Histidine kinase
SUTH_02097	COG2205	protein histidine kinase activity
SUTH_02097	COG3850	Histidine kinase
SUTH_02097	COG3437	response regulator, receiver
SUTH_02111	COG0784	Response regulator, receiver
SUTH_02111	COG3437	response regulator, receiver
SUTH_02112	COG2969	positive regulation of protein catabolic process
SUTH_02113	COG0625	glutathione transferase activity
SUTH_02114	COG2857	Cytochrome c1
SUTH_02115	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SUTH_02116	COG0723	plastoquinol--plastocyanin reductase activity
SUTH_02117	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SUTH_02118	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SUTH_02119	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SUTH_02120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SUTH_02126	COG2414	aldehyde ferredoxin oxidoreductase
SUTH_02127	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SUTH_02129	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SUTH_02135	COG1136	(ABC) transporter
SUTH_02143	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SUTH_02147	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SUTH_02153	COG0693	protein deglycase activity
SUTH_02154	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SUTH_02156	COG1522	sequence-specific DNA binding
SUTH_02158	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SUTH_02159	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SUTH_02160	COG0303	'Molybdopterin
SUTH_02161	COG0501	Belongs to the peptidase M48B family
SUTH_02162	COG0676	glucose-6-phosphate 1-epimerase activity
SUTH_02164	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SUTH_02165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SUTH_02166	COG1136	(ABC) transporter
SUTH_02166	COG0577	efflux transmembrane transporter activity
SUTH_02167	COG1136	(ABC) transporter
SUTH_02167	COG0577	efflux transmembrane transporter activity
SUTH_02168	COG4591	ABC-type transport system involved in lipoprotein release permease component
SUTH_02168	COG1136	(ABC) transporter
SUTH_02172	COG1393	Belongs to the ArsC family
SUTH_02173	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SUTH_02174	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SUTH_02175	COG0697	spore germination
SUTH_02179	COG2161	toxin-antitoxin pair type II binding
SUTH_02181	COG1472	Belongs to the glycosyl hydrolase 3 family
SUTH_02182	COG0736	holo-[acyl-carrier-protein] synthase activity
SUTH_02183	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SUTH_02184	COG1381	Involved in DNA repair and RecF pathway recombination
SUTH_02185	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SUTH_02186	COG0571	ribonuclease III activity
SUTH_02188	COG0681	Belongs to the peptidase S26 family
SUTH_02189	COG0481	GTPase activity
SUTH_02191	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SUTH_02196	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SUTH_02199	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SUTH_02202	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SUTH_02203	COG0416	fatty acid biosynthetic process
SUTH_02204	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SUTH_02206	COG0424	maF-like protein
SUTH_02207	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SUTH_02209	COG0709	Synthesizes selenophosphate from selenide and ATP
SUTH_02210	COG0438	transferase activity, transferring glycosyl groups
SUTH_02211	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SUTH_02216	COG0306	phosphate transporter
SUTH_02219	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SUTH_02220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SUTH_02221	COG2917	probably involved in intracellular septation
SUTH_02222	COG2350	Protein conserved in bacteria
SUTH_02223	COG0271	Belongs to the BolA IbaG family
SUTH_02224	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SUTH_02225	COG0047	phosphoribosylformylglycinamidine synthase activity
SUTH_02225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SUTH_02226	COG3706	GGDEF domain
SUTH_02227	COG3118	belongs to the thioredoxin family
SUTH_02229	COG0473	3-isopropylmalate dehydrogenase activity
SUTH_02230	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
SUTH_02233	COG0778	Nitroreductase
SUTH_02237	COG4372	Transposase
SUTH_02250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SUTH_02251	COG0583	DNA-binding transcription factor activity
SUTH_02252	COG0477	Major facilitator Superfamily
SUTH_02254	COG1573	uracil-dna glycosylase
SUTH_02256	COG1214	PFAM Peptidase M22, glycoprotease
SUTH_02257	COG0330	HflC and HflK could
SUTH_02259	COG0776	regulation of translation
SUTH_02260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SUTH_02261	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SUTH_02262	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SUTH_02263	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SUTH_02264	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SUTH_02265	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SUTH_02269	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SUTH_02270	COG0575	Belongs to the CDS family
SUTH_02271	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SUTH_02272	COG0233	cytoplasmic translational termination
SUTH_02273	COG0528	UMP kinase activity
SUTH_02274	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SUTH_02275	COG0052	Belongs to the universal ribosomal protein uS2 family
SUTH_02277	COG0024	Methionine aminopeptidase
SUTH_02278	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SUTH_02286	COG1177	transmembrane transport
SUTH_02287	COG1176	ABC-type spermidine putrescine transport system, permease component I
SUTH_02288	COG3842	ATPase activity
SUTH_02291	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SUTH_02293	COG1322	Protein conserved in bacteria
SUTH_02294	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SUTH_02296	COG2030	dehydratase
SUTH_02299	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SUTH_02299	COG1918	ferrous iron import across plasma membrane
SUTH_02302	COG2176	DNA-directed DNA polymerase activity
SUTH_02302	COG5002	protein histidine kinase activity
SUTH_02304	COG0745	RESPONSE REGULATOR receiver
SUTH_02305	COG5002	protein histidine kinase activity
SUTH_02307	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SUTH_02313	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SUTH_02315	COG3228	Belongs to the MtfA family
SUTH_02319	COG1960	acyl-CoA dehydrogenase activity
SUTH_02320	COG1960	acyl-CoA dehydrogenase activity
SUTH_02321	COG1960	acyl-CoA dehydrogenase activity
SUTH_02322	COG1024	Enoyl-CoA hydratase
SUTH_02326	COG2030	dehydratase
SUTH_02326	COG1012	belongs to the aldehyde dehydrogenase family
SUTH_02327	COG0318	PFAM AMP-dependent synthetase and ligase
SUTH_02328	COG1024	Enoyl-CoA hydratase
SUTH_02329	COG0596	Alpha beta hydrolase
SUTH_02335	COG2814	Major facilitator Superfamily
SUTH_02336	COG0318	PFAM AMP-dependent synthetase and ligase
SUTH_02338	COG1960	acyl-CoA dehydrogenase activity
SUTH_02339	COG1960	acyl-CoA dehydrogenase activity
SUTH_02344	COG0564	pseudouridine synthase activity
SUTH_02347	COG2205	protein histidine kinase activity
SUTH_02347	COG0784	Response regulator, receiver
SUTH_02347	COG2198	Histidine kinase
SUTH_02349	COG3118	belongs to the thioredoxin family
SUTH_02352	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
SUTH_02353	COG0148	phosphopyruvate hydratase activity
SUTH_02355	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SUTH_02356	COG0504	CTP synthase activity
SUTH_02358	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SUTH_02363	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SUTH_02364	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SUTH_02364	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SUTH_02367	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SUTH_02370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SUTH_02373	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SUTH_02373	COG1672	PFAM Archaeal ATPase
SUTH_02375	COG0527	aspartate kinase activity
SUTH_02378	COG0720	synthase
SUTH_02379	COG0318	PFAM AMP-dependent synthetase and ligase
SUTH_02380	COG0625	glutathione transferase activity
SUTH_02381	COG1024	Enoyl-CoA hydratase
SUTH_02385	COG1715	Restriction endonuclease
SUTH_02387	COG1028	Short-chain dehydrogenase reductase Sdr
SUTH_02398	COG4964	Belongs to the GSP D family
SUTH_02413	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SUTH_02416	COG0321	lipoyl(octanoyl) transferase activity
SUTH_02416	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SUTH_02417	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
SUTH_02418	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SUTH_02420	COG0714	Associated with various cellular activities
SUTH_02423	COG2951	lytic endotransglycosylase activity
SUTH_02425	COG4942	peptidase
SUTH_02425	COG1388	LysM domain
SUTH_02426	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SUTH_02427	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SUTH_02433	COG0776	regulation of translation
SUTH_02434	COG0072	phenylalanine-tRNA ligase activity
SUTH_02434	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SUTH_02435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SUTH_02436	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SUTH_02437	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SUTH_02438	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SUTH_02439	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SUTH_02442	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SUTH_02443	COG0604	alcohol dehydrogenase
SUTH_02444	COG0791	NLP P60 protein
SUTH_02445	COG1840	ABC-type Fe3 transport system, periplasmic component
SUTH_02447	COG1178	ABC-type Fe3 transport system permease component
SUTH_02449	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SUTH_02450	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
SUTH_02452	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SUTH_02454	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SUTH_02455	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SUTH_02456	COG0740	serine-type endopeptidase activity
SUTH_02457	COG0544	peptidyl-prolyl cis-trans isomerase activity
SUTH_02459	COG1562	ergosterol biosynthetic process
SUTH_02461	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SUTH_02462	COG4181	ATPase activity
SUTH_02464	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SUTH_02466	COG3275	phosphorelay sensor kinase activity
SUTH_02468	COG4106	trans-aconitate 2-methyltransferase activity
SUTH_02470	COG0045	succinate-CoA ligase (ADP-forming) activity
SUTH_02470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SUTH_02470	COG1042	CoA-binding domain protein
SUTH_02471	COG2818	Glycosylase
SUTH_02474	COG2271	Major facilitator Superfamily
SUTH_02478	COG0542	response to heat
SUTH_02484	COG0314	molybdopterin synthase activity
SUTH_02485	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SUTH_02486	COG0303	'Molybdopterin
SUTH_02487	COG1763	Mo-molybdopterin cofactor biosynthetic process
SUTH_02489	COG1199	ATP-dependent helicase activity
SUTH_02492	COG0437	4 iron, 4 sulfur cluster binding
SUTH_02501	COG0033	Phosphoglucomutase
SUTH_02503	COG5002	protein histidine kinase activity
SUTH_02503	COG3447	MASE1 domain protein
SUTH_02503	COG5001	Diguanylate cyclase
SUTH_02505	COG0745	RESPONSE REGULATOR receiver
SUTH_02507	COG0784	Response regulator, receiver
SUTH_02507	COG2205	protein histidine kinase activity
SUTH_02507	COG5002	protein histidine kinase activity
SUTH_02508	COG3437	response regulator, receiver
SUTH_02509	COG0745	RESPONSE REGULATOR receiver
SUTH_02514	COG3609	addiction module antidote protein, CC2985 family
SUTH_02522	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SUTH_02523	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SUTH_02528	COG0543	2 iron, 2 sulfur cluster binding
SUTH_02528	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SUTH_02529	COG1028	Short-chain dehydrogenase reductase Sdr
SUTH_02532	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SUTH_02533	COG1999	signal sequence binding
SUTH_02535	COG0469	pyruvate kinase activity
SUTH_02535	COG0469	pyruvate kinase activity
SUTH_02553	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SUTH_02555	COG1136	(ABC) transporter
SUTH_02555	COG0577	efflux transmembrane transporter activity
SUTH_02558	COG1999	signal sequence binding
SUTH_02563	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SUTH_02566	COG1122	ATPase activity
SUTH_02567	COG0348	domain, Protein
SUTH_02568	COG0437	4 iron, 4 sulfur cluster binding
SUTH_02572	COG2863	cytochrome
SUTH_02573	COG4263	nitrous-oxide reductase activity
SUTH_02575	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
SUTH_02586	COG2010	Cytochrome c
SUTH_02587	COG4206	TonB-dependent receptor
SUTH_02588	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SUTH_02589	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SUTH_02592	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SUTH_02593	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SUTH_02596	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SUTH_02597	COG1492	cobalamin metabolic process
SUTH_02599	COG0318	PFAM AMP-dependent synthetase and ligase
SUTH_02611	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SUTH_02621	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SUTH_02622	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SUTH_02625	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SUTH_02627	COG3039	Transposase
SUTH_02640	COG0277	FAD linked oxidase domain protein
SUTH_02641	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SUTH_02644	COG1028	Short-chain dehydrogenase reductase Sdr
SUTH_02645	COG3243	poly(R)-hydroxyalkanoic acid synthase
SUTH_02649	COG0564	pseudouridine synthase activity
SUTH_02651	COG1250	3-hydroxyacyl-CoA dehydrogenase
SUTH_02655	COG3850	Histidine kinase
SUTH_02655	COG3437	response regulator, receiver
SUTH_02655	COG2205	protein histidine kinase activity
SUTH_02655	COG4999	Histidine kinase
SUTH_02656	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SUTH_02657	COG1511	domain protein
SUTH_02657	COG3264	Mechanosensitive ion channel
SUTH_02658	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SUTH_02659	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SUTH_02659	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SUTH_02661	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SUTH_02663	COG0586	Pfam SNARE associated Golgi protein
SUTH_02664	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SUTH_02667	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SUTH_02668	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SUTH_02669	COG0628	permease
SUTH_02670	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SUTH_02678	COG1595	DNA-templated transcription, initiation
SUTH_02682	COG0028	Belongs to the TPP enzyme family
SUTH_02687	COG1722	exodeoxyribonuclease VII activity
SUTH_02688	COG0142	geranyltranstransferase activity
SUTH_02689	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SUTH_02690	COG1469	GTP cyclohydrolase I activity
SUTH_02691	COG0335	large ribosomal subunit rRNA binding
SUTH_02692	COG0336	Belongs to the RNA methyltransferase TrmD family
SUTH_02693	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SUTH_02694	COG0228	four-way junction DNA binding
SUTH_02695	COG0284	orotidine-5'-phosphate decarboxylase activity
SUTH_02697	COG1295	ribonuclease BN
SUTH_02700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SUTH_02702	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SUTH_02703	COG0440	acetolactate synthase activity
SUTH_02704	COG0028	Belongs to the TPP enzyme family
SUTH_02710	COG0795	lipopolysaccharide-transporting ATPase activity
SUTH_02711	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SUTH_02714	COG0625	glutathione transferase activity
SUTH_02719	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SUTH_02720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SUTH_02721	COG1862	Preprotein translocase
SUTH_02722	COG0343	queuine tRNA-ribosyltransferase activity
SUTH_02723	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SUTH_02725	COG3158	transport of potassium into the cell
SUTH_02729	COG2010	Cytochrome c
SUTH_02730	COG0737	Belongs to the 5'-nucleotidase family
SUTH_02731	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SUTH_02732	COG0577	efflux transmembrane transporter activity
SUTH_02732	COG1136	(ABC) transporter
SUTH_02733	COG0577	efflux transmembrane transporter activity
SUTH_02733	COG1136	(ABC) transporter
SUTH_02738	COG0667	Aldo Keto reductase
SUTH_02742	COG0745	RESPONSE REGULATOR receiver
SUTH_02743	COG2205	protein histidine kinase activity
SUTH_02744	COG0513	Belongs to the DEAD box helicase family
SUTH_02745	COG0179	Fumarylacetoacetate (FAA) hydrolase
SUTH_02747	COG0745	RESPONSE REGULATOR receiver
SUTH_02748	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SUTH_02749	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SUTH_02750	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SUTH_02753	COG0617	tRNA 3'-terminal CCA addition
SUTH_02754	COG0525	valine-tRNA ligase activity
SUTH_02757	COG2210	Belongs to the sulfur carrier protein TusA family
SUTH_02758	COG0425	Belongs to the sulfur carrier protein TusA family
SUTH_02759	COG3302	dmso reductase anchor subunit
SUTH_02760	COG0437	4 iron, 4 sulfur cluster binding
SUTH_02761	COG0243	molybdopterin cofactor binding
SUTH_02767	COG1233	COG1233 Phytoene dehydrogenase and related
SUTH_02769	COG2048	Heterodisulfide reductase, subunit B
SUTH_02773	COG2046	Belongs to the sulfate adenylyltransferase family
SUTH_02774	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SUTH_02778	COG0028	Belongs to the TPP enzyme family
SUTH_02786	COG0463	Glycosyl transferase, family 2
SUTH_02788	COG1131	(ABC) transporter
SUTH_02794	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SUTH_02800	COG0631	protein serine/threonine phosphatase activity
SUTH_02801	COG2815	serine threonine protein kinase
SUTH_02801	COG0515	serine threonine protein kinase
SUTH_02802	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SUTH_02803	COG0045	succinate-CoA ligase (ADP-forming) activity
SUTH_02804	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SUTH_02806	COG0716	FMN binding
SUTH_02808	COG1024	Enoyl-CoA hydratase
SUTH_02809	COG2050	protein possibly involved in aromatic compounds catabolism
SUTH_02810	COG0183	Belongs to the thiolase family
SUTH_02814	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SUTH_02815	COG0625	glutathione transferase activity
SUTH_02825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SUTH_02827	COG1013	pyruvate-flavodoxin oxidoreductase activity
SUTH_02828	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SUTH_02828	COG0674	pyruvate-flavodoxin oxidoreductase activity
SUTH_02830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SUTH_02834	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SUTH_02835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SUTH_02837	COG0140	phosphoribosyl-ATP diphosphatase activity
SUTH_02838	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SUTH_02839	COG0107	imidazoleglycerol-phosphate synthase activity
SUTH_02840	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SUTH_02841	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SUTH_02843	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SUTH_02845	COG1487	ribonuclease activity
SUTH_02847	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SUTH_02848	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SUTH_02849	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SUTH_02851	COG0842	Transport permease protein
SUTH_02852	COG1131	(ABC) transporter
SUTH_02853	COG3113	response to antibiotic
SUTH_02856	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SUTH_02857	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SUTH_02858	COG1127	ABC transporter
SUTH_02860	COG3267	Type II secretory pathway component ExeA
SUTH_02860	COG3409	Peptidoglycan-binding domain 1 protein
SUTH_02871	COG0789	Transcriptional regulator
SUTH_02872	COG1028	Short-chain dehydrogenase reductase Sdr
SUTH_02873	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SUTH_02874	COG1960	acyl-CoA dehydrogenase activity
SUTH_02875	COG1024	Enoyl-CoA hydratase
SUTH_02877	COG3246	L-lysine catabolic process to acetate
SUTH_02878	COG0546	phosphoglycolate phosphatase activity
SUTH_02881	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SUTH_02882	COG0134	indole-3-glycerol-phosphate synthase activity
SUTH_02883	COG4191	Histidine kinase
SUTH_02888	COG0446	pyridine nucleotide-disulphide oxidoreductase
SUTH_02892	COG3437	response regulator, receiver
SUTH_02896	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SUTH_02899	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SUTH_02900	COG2186	Transcriptional regulator
SUTH_02901	COG0861	Integral membrane protein TerC family
SUTH_02905	COG0418	dihydroorotase activity
SUTH_02906	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SUTH_02907	COG0792	nuclease activity
SUTH_02909	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SUTH_02910	COG2823	Periplasmic or secreted lipoprotein
SUTH_02911	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SUTH_02920	COG0629	single-stranded DNA binding
SUTH_02921	COG2814	Major facilitator Superfamily
SUTH_02924	COG0671	phosphoesterase, PA-phosphatase related
SUTH_02925	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SUTH_02926	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SUTH_02927	COG0598	Magnesium transport protein CorA
SUTH_02929	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SUTH_02931	COG0247	lactate metabolic process
SUTH_02932	COG0277	FAD linked oxidase domain protein
SUTH_02933	COG0277	FAD linked oxidase domain protein
SUTH_02935	COG3622	Belongs to the hyi family
SUTH_02936	COG3038	cytochrome b561
SUTH_02938	COG2353	YceI-like domain
SUTH_02945	COG1304	FMN binding
SUTH_02948	COG3039	Transposase
SUTH_02953	COG3260	NADH ubiquinone oxidoreductase 20
SUTH_02954	COG3261	NADH dehydrogenase
SUTH_02954	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
SUTH_02955	COG0651	ATP synthesis coupled electron transport
SUTH_02957	COG0650	Formate hydrogenlyase subunit 4
SUTH_02958	COG0651	ATP synthesis coupled electron transport
SUTH_02960	COG2096	Adenosyltransferase
SUTH_02961	COG3706	GGDEF domain
SUTH_02965	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SUTH_02967	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SUTH_02968	COG0840	transmembrane signaling receptor activity
SUTH_02970	COG0674	pyruvate-flavodoxin oxidoreductase activity
SUTH_02971	COG1013	pyruvate-flavodoxin oxidoreductase activity
SUTH_02972	COG0493	'glutamate synthase
SUTH_02973	COG3706	GGDEF domain
SUTH_02973	COG0745	RESPONSE REGULATOR receiver
SUTH_02974	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SUTH_02977	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SUTH_02978	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SUTH_02979	COG0022	dehydrogenase e1 component
SUTH_02979	COG0508	dehydrogenase complex catalyzes the overall conversion of
SUTH_02981	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SUTH_02982	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SUTH_02985	COG1067	ATP-dependent peptidase activity
SUTH_02986	COG2920	part of a sulfur-relay system
SUTH_02989	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SUTH_02990	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SUTH_02991	COG0408	coproporphyrinogen oxidase activity
SUTH_02993	COG2959	enzyme of heme biosynthesis
SUTH_02995	COG0181	hydroxymethylbilane synthase activity
SUTH_02996	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SUTH_02999	COG0280	phosphate acetyltransferase
SUTH_02999	COG0281	malic enzyme
SUTH_03000	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SUTH_03009	COG0142	geranyltranstransferase activity
SUTH_03011	COG3275	phosphorelay sensor kinase activity
SUTH_03012	COG0165	Argininosuccinate lyase
SUTH_03013	COG0515	serine threonine protein kinase
SUTH_03013	COG2815	serine threonine protein kinase
SUTH_03015	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SUTH_03016	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SUTH_03017	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
SUTH_03019	COG2967	ApaG domain
SUTH_03025	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SUTH_03027	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
SUTH_03028	COG1024	Enoyl-CoA hydratase
SUTH_03030	COG0436	Aminotransferase
SUTH_03031	COG3706	GGDEF domain
SUTH_03034	COG2084	Dehydrogenase
SUTH_03035	COG2084	Dehydrogenase
SUTH_03037	COG5001	Diguanylate cyclase
SUTH_03037	COG4251	negative regulation of phosphorylation
SUTH_03037	COG3706	GGDEF domain
SUTH_03037	COG2203	Gaf domain
SUTH_03038	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SUTH_03041	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SUTH_03042	COG3164	Protein of unknown function
SUTH_03043	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SUTH_03044	COG0312	modulator of DNA gyrase
SUTH_03045	COG3706	GGDEF domain
SUTH_03045	COG0745	RESPONSE REGULATOR receiver
SUTH_03046	COG1546	Belongs to the CinA family
SUTH_03046	COG1058	Belongs to the CinA family
SUTH_03048	COG1643	Atp-dependent helicase
SUTH_03049	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SUTH_03050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SUTH_03057	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SUTH_03058	COG2205	protein histidine kinase activity
SUTH_03058	COG0784	Response regulator, receiver
SUTH_03058	COG2198	Histidine kinase
SUTH_03058	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SUTH_03060	COG3347	Dehydrogenase
SUTH_03060	COG1028	Short-chain dehydrogenase reductase Sdr
SUTH_03061	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SUTH_03062	COG0653	protein targeting
SUTH_03063	COG0739	heme binding
SUTH_03066	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SUTH_03067	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SUTH_03069	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SUTH_03070	COG1181	Belongs to the D-alanine--D-alanine ligase family
SUTH_03071	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SUTH_03072	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SUTH_03073	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SUTH_03074	COG0772	Belongs to the SEDS family
SUTH_03075	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SUTH_03076	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SUTH_03077	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SUTH_03078	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SUTH_03081	COG0275	rRNA processing
SUTH_03082	COG2001	Belongs to the MraZ family
SUTH_03083	COG0688	phosphatidylethanolamine metabolic process
SUTH_03084	COG0475	glutathione-regulated potassium exporter activity
SUTH_03085	COG0501	Belongs to the peptidase M48B family
SUTH_03086	COG0583	DNA-binding transcription factor activity
SUTH_03092	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SUTH_03097	COG1139	Iron-sulfur cluster binding protein
SUTH_03098	COG0247	lactate metabolic process
SUTH_03099	COG1414	Transcriptional regulator
SUTH_03100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SUTH_03101	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SUTH_03102	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SUTH_03103	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SUTH_03104	COG5611	PilT protein domain protein
SUTH_03115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SUTH_03116	COG0739	heme binding
SUTH_03117	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SUTH_03118	COG0316	Belongs to the HesB IscA family
SUTH_03121	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SUTH_03122	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SUTH_03123	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SUTH_03125	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SUTH_03127	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SUTH_03128	COG1702	phosphate starvation-inducible protein PhoH
SUTH_03129	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SUTH_03130	COG4535	Mg2 and Co2 transporter CorC
SUTH_03131	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SUTH_03133	COG0752	glycyl-tRNA synthetase alpha subunit
SUTH_03134	COG0751	glycine-tRNA ligase activity
SUTH_03135	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SUTH_03139	COG3039	Transposase
SUTH_03142	COG3384	dioxygenase
SUTH_03143	COG1720	tRNA m6t6A37 methyltransferase activity
SUTH_03147	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SUTH_03148	COG2205	protein histidine kinase activity
SUTH_03148	COG0784	Response regulator, receiver
SUTH_03149	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SUTH_03150	COG0745	RESPONSE REGULATOR receiver
SUTH_03151	COG0642	Histidine kinase
SUTH_03154	COG0659	secondary active sulfate transmembrane transporter activity
SUTH_03157	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SUTH_03159	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
SUTH_03163	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SUTH_03164	COG0521	Mo-molybdopterin cofactor biosynthetic process
SUTH_03165	COG1127	ABC transporter
SUTH_03167	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SUTH_03168	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SUTH_03169	COG0837	glucose binding
SUTH_03171	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SUTH_03172	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SUTH_03174	COG1449	Belongs to the glycosyl hydrolase 57 family
SUTH_03176	COG0166	Belongs to the GPI family
SUTH_03177	COG0297	glycogen (starch) synthase activity
SUTH_03180	COG1982	Orn Lys Arg decarboxylase major
SUTH_03181	COG0717	Belongs to the dCTP deaminase family
SUTH_03182	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SUTH_03183	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SUTH_03184	COG0156	8-amino-7-oxononanoate synthase activity
SUTH_03185	COG0489	protein tyrosine kinase activity
SUTH_03191	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SUTH_03191	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SUTH_03192	COG1254	Belongs to the acylphosphatase family
SUTH_03193	COG0450	alkyl hydroperoxide reductase
SUTH_03205	COG2050	protein possibly involved in aromatic compounds catabolism
SUTH_03213	COG0281	malic enzyme
SUTH_03213	COG0280	phosphate acetyltransferase
SUTH_03215	COG2197	response regulator
SUTH_03217	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SUTH_03223	COG1028	Short-chain dehydrogenase reductase Sdr
SUTH_03224	COG2267	carboxylic ester hydrolase activity
SUTH_03227	COG0210	DNA helicase
SUTH_03230	COG0495	leucyl-tRNA aminoacylation
SUTH_03232	COG1466	dna polymerase III delta subunit
SUTH_03233	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SUTH_03234	COG3706	GGDEF domain
SUTH_03237	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SUTH_03240	COG0659	secondary active sulfate transmembrane transporter activity
SUTH_03244	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SUTH_03245	COG4974	Belongs to the 'phage' integrase family
SUTH_03248	COG2860	membrane
SUTH_03250	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SUTH_03253	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SUTH_03262	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SUTH_03263	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SUTH_03266	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SUTH_03269	COG1752	Esterase of the alpha-beta hydrolase superfamily
SUTH_03270	COG0322	excinuclease ABC activity
SUTH_03273	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SUTH_03274	COG1950	PFAM Membrane protein of
SUTH_03275	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SUTH_03280	COG0433	COG0433 Predicted ATPase
SUTH_03281	COG0217	transcriptional regulatory protein
SUTH_03283	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SUTH_03285	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SUTH_03287	COG0632	four-way junction helicase activity
SUTH_03288	COG2255	four-way junction helicase activity
SUTH_03289	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SUTH_03292	COG0824	Thioesterase
SUTH_03296	COG0823	Involved in the tonB-independent uptake of proteins
SUTH_03299	COG0602	queuosine metabolic process
SUTH_03300	COG1832	CoA-binding protein
SUTH_03301	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SUTH_03302	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SUTH_03304	COG0012	GTP binding
SUTH_03305	COG0193	aminoacyl-tRNA hydrolase activity
SUTH_03306	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SUTH_03307	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SUTH_03309	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SUTH_03310	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
SUTH_03312	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SUTH_03313	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SUTH_03314	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SUTH_03315	COG0742	ribosomal rna small subunit methyltransferase
SUTH_03316	COG0612	Peptidase, M16
SUTH_03317	COG0612	Peptidase, M16
SUTH_03319	COG2884	Cell division ATP-binding protein ftsE
SUTH_03320	COG2177	Part of the ABC transporter FtsEX involved in
SUTH_03322	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SUTH_03323	COG1999	signal sequence binding
SUTH_03324	COG0109	protoheme IX farnesyltransferase activity
SUTH_03325	COG1999	signal sequence binding
SUTH_03329	COG1845	cytochrome c oxidase, subunit III
SUTH_03331	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SUTH_03333	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SUTH_03334	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SUTH_03335	COG0511	ligase activity, forming carbon-carbon bonds
SUTH_03336	COG0439	Biotin carboxylase
SUTH_03337	COG2264	protein methyltransferase activity
SUTH_03341	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SUTH_03342	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SUTH_03345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SUTH_03349	COG1215	transferase activity, transferring glycosyl groups
SUTH_03350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SUTH_03351	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SUTH_03356	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SUTH_03360	COG0546	phosphoglycolate phosphatase activity
SUTH_03361	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SUTH_03362	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SUTH_03363	COG0363	glucosamine-6-phosphate deaminase activity
SUTH_03365	COG2192	nodulation
SUTH_03370	COG2192	nodulation
SUTH_03373	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SUTH_03375	COG4310	Domain of unknown function (DUF2172)
SUTH_03376	COG2089	acid synthase
SUTH_03378	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SUTH_03379	COG1454	alcohol dehydrogenase
SUTH_03384	COG1045	serine acetyltransferase
SUTH_03388	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SUTH_03389	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SUTH_03394	COG0859	PFAM glycosyl transferase family 9
SUTH_03397	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SUTH_03398	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SUTH_03401	COG1309	transcriptional regulator
SUTH_03405	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SUTH_03407	COG1968	undecaprenyl-diphosphatase activity
SUTH_03408	COG3150	esterase
SUTH_03413	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SUTH_03414	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SUTH_03417	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SUTH_03418	COG0352	thiamine-phosphate diphosphorylase activity
SUTH_03419	COG0351	phosphomethylpyrimidine kinase
SUTH_03423	COG0840	transmembrane signaling receptor activity
SUTH_03424	COG0643	Histidine kinase
SUTH_03424	COG2198	Histidine kinase
SUTH_03427	COG1902	pentaerythritol trinitrate reductase activity
SUTH_03433	COG2205	protein histidine kinase activity
SUTH_03434	COG0745	RESPONSE REGULATOR receiver
SUTH_03444	COG0439	Biotin carboxylase
SUTH_03445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SUTH_03448	COG1802	Transcriptional regulator
SUTH_03449	COG0412	Dienelactone hydrolase
SUTH_03458	COG1324	tolerance protein
SUTH_03459	COG4232	protein-disulfide reductase activity
SUTH_03462	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SUTH_03463	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SUTH_03465	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SUTH_03466	COG1546	Belongs to the CinA family
SUTH_03467	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SUTH_03468	COG2137	regulation of response to DNA damage stimulus
SUTH_03470	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SUTH_03471	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SUTH_03473	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SUTH_03477	COG1902	pentaerythritol trinitrate reductase activity
SUTH_03477	COG0446	pyridine nucleotide-disulphide oxidoreductase
SUTH_03478	COG1910	domain protein
SUTH_03480	COG1126	abc transporter atp-binding protein
SUTH_03482	COG0488	(ABC) transporter
SUTH_03486	COG0488	(ABC) transporter
SUTH_03488	COG2808	Putative FMN-binding domain
SUTH_03492	COG2201	protein-glutamate methylesterase activity
SUTH_03494	COG0583	DNA-binding transcription factor activity
SUTH_03496	COG0824	Thioesterase
SUTH_03498	COG2814	Major facilitator Superfamily
SUTH_03508	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SUTH_03508	COG2813	Specifically methylates the guanine in position
SUTH_03509	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SUTH_03510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SUTH_03511	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SUTH_03515	COG0189	ligase activity
SUTH_03517	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SUTH_03522	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SUTH_03526	COG1132	(ABC) transporter
SUTH_03527	COG0438	transferase activity, transferring glycosyl groups
SUTH_03532	COG0165	Argininosuccinate lyase
SUTH_03534	COG1216	Glycosyl transferase, family 2
SUTH_03537	COG0438	transferase activity, transferring glycosyl groups
SUTH_03538	COG0438	transferase activity, transferring glycosyl groups
SUTH_03539	COG0859	PFAM glycosyl transferase family 9
SUTH_03542	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SUTH_03544	COG0730	response to heat
SUTH_03545	COG0625	glutathione transferase activity
SUTH_03548	COG0204	Acyl-transferase
SUTH_03549	COG0318	PFAM AMP-dependent synthetase and ligase
SUTH_03552	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SUTH_03554	COG1802	Transcriptional regulator
SUTH_03555	COG1011	Hydrolase
SUTH_03558	COG0579	oxidoreductase
SUTH_03559	COG1024	Enoyl-CoA hydratase
SUTH_03572	COG0617	tRNA 3'-terminal CCA addition
SUTH_03574	COG0741	lytic transglycosylase activity
SUTH_03575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SUTH_03576	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SUTH_03578	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SUTH_03598	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SUTH_03600	COG0534	Mate efflux family protein
SUTH_03602	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
SUTH_03610	COG2226	methyltransferase
SUTH_03616	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SUTH_03618	COG1309	transcriptional regulator
SUTH_03619	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SUTH_03620	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SUTH_03621	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SUTH_03622	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SUTH_03623	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SUTH_03624	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SUTH_03626	COG0356	it plays a direct role in the translocation of protons across the membrane
SUTH_03628	COG1475	DNA binding
SUTH_03629	COG1192	Involved in chromosome partitioning
SUTH_03630	COG0357	Ribosomal RNA small subunit methyltransferase G
SUTH_03631	COG0445	tRNA wobble uridine modification
SUTH_03633	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SUTH_03634	COG0706	membrane insertase activity
SUTH_03635	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SUTH_03636	COG0594	ribonuclease P activity
SUTH_03637	COG0230	Belongs to the bacterial ribosomal protein bL34 family