locus-tag class description Sdel_0001 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) Sdel_0002 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Sdel_0003 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Sdel_0004 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Sdel_0005 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Sdel_0007 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) Sdel_0009 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) Sdel_0010 ENOG4105CEN a g-specific adenine glycosylase Sdel_0012 ENOG4105C2C drug resistance transporter, Bcr CflA Sdel_0016 ENOG4105C8Q Methyl-accepting chemotaxis Sdel_0020 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein Sdel_0021 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Sdel_0022 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Sdel_0024 ENOG4108S9F abc transporter, atp-binding protein Sdel_0025 ENOG4107R73 Mate efflux family protein Sdel_0030 ENOG4108RPX mosc domain containing protein Sdel_0033 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein Sdel_0039 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Sdel_0041 ENOG4105C01 Dihydroxy-acid dehydratase Sdel_0042 ENOG41081FY multiple antibiotic resistance (MarC)-related Sdel_0044 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Sdel_0045 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Sdel_0046 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Sdel_0047 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Sdel_0048 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase Sdel_0049 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Sdel_0054 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Sdel_0055 ENOG4107QTF adenylosuccinate lyase Sdel_0056 ENOG4105EI2 Pseudouridine synthase Sdel_0057 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase Sdel_0059 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Sdel_0061 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Sdel_0062 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Sdel_0063 ENOG4105CN5 Metallo-Beta-Lactamase Sdel_0064 ENOG4105C2X Arabinose 5-phosphate isomerase Sdel_0065 ENOG4105FE9 pseudouridine synthase Sdel_0066 ENOG4105D1H recombination factor protein RarA Sdel_0068 ENOG4105VM1 flagellar Sdel_0070 ENOG4105CXB phosphoribosylaminoimidazole synthetase Sdel_0071 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Sdel_0072 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Sdel_0074 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Sdel_0075 ENOG4108317 Binds directly to 16S ribosomal RNA (By similarity) Sdel_0079 ENOG410813J This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Sdel_0080 ENOG4105E0M Sulfatase Sdel_0081 ENOG4105C22 threonyL-tRNA synthetase Sdel_0082 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Sdel_0084 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Sdel_0085 ENOG4105C58 cytochrome c oxidase accessory protein ccog Sdel_0090 ENOG4106032 Glutathionylspermidine synthase Sdel_0091 ENOG4105C5I Dehydrogenase Sdel_0092 ENOG4108VPT UPF0234 protein Sdel_0094 ENOG41080IJ Diacylglycerol kinase Sdel_0096 ENOG4105BZU Histidine kinase Sdel_0097 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Sdel_0101 ENOG4105DHJ ABC, transporter Sdel_0102 ENOG4105CY3 ABC transporter, permease Sdel_0104 ENOG4108YZA Nitrogen regulatory protein pii Sdel_0105 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Sdel_0106 ENOG4107QQR Sporulation Sdel_0112 ENOG4105C8Q Methyl-accepting chemotaxis Sdel_0113 ENOG4105C8Q Methyl-accepting chemotaxis Sdel_0114 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) Sdel_0115 ENOG4108YXA Membrane Sdel_0117 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Sdel_0118 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Sdel_0119 ENOG4105CPC Aldo Keto reductase Sdel_0120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Sdel_0123 ENOG4105E5Q amino acid AbC transporter Sdel_0124 ENOG4106PMH Extracellular solute-binding protein family 3 Sdel_0130 ENOG4105FDK ABC transporter Sdel_0134 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) Sdel_0136 ENOG4105CEY Amp-dependent synthetase and ligase Sdel_0138 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Sdel_0139 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Sdel_0140 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Sdel_0141 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Sdel_0145 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) Sdel_0146 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Sdel_0148 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Sdel_0149 ENOG4105D65 subunit l Sdel_0150 ENOG4105C8S subunit m Sdel_0151 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Sdel_0153 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Sdel_0157 ENOG4105C8Q Methyl-accepting chemotaxis Sdel_0159 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Sdel_0160 ENOG4105CVM Molybdenum cofactor synthesis domain protein Sdel_0162 ENOG4107YV6 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Sdel_0165 ENOG4105C2N RNA methyltransferase TrmH family group 3 Sdel_0168 ENOG4105CHM Aminotransferase Sdel_0169 ENOG4105D6E homoserine dehydrogenase Sdel_0170 ENOG41082UM UPF0102 protein Sdel_0172 ENOG4105C3M thioredoxin reductase Sdel_0173 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Sdel_0175 ENOG4105N5T Radical SAM Protein Sdel_0178 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Sdel_0180 ENOG4105CM2 brancheD-chain amino acid aminotransferase Sdel_0181 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Sdel_0183 ENOG4105WPN DNA integration recombination invertion protein Sdel_0184 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) Sdel_0185 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Sdel_0186 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Sdel_0189 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Sdel_0197 ENOG4105VYW UPF0251 protein Sdel_0198 ENOG4105CUZ uba thif-type nad fad binding protein Sdel_0199 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Sdel_0200 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Sdel_0201 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Sdel_0202 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Sdel_0203 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) Sdel_0204 ENOG4107R88 Chemotaxis protein (CheV) Sdel_0205 ENOG4105CBS Chea signal transduction histidine kinase Sdel_0206 ENOG4108V3W Chemotaxis protein, CheW Sdel_0208 ENOG4105EAC phosphoserine phosphatase Sdel_0210 ENOG4105CZX twitching motility protein Sdel_0211 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Sdel_0212 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Sdel_0214 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Sdel_0216 ENOG4105CQC Prephenate dehydratase Sdel_0217 ENOG4105CIH Imidazole acetol-phosphate transaminase Sdel_0218 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) Sdel_0219 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Sdel_0221 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Sdel_0223 ENOG4105D3R alkyl hydroperoxide reductase Sdel_0225 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Sdel_0228 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Sdel_0229 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Sdel_0230 ENOG4105EVN Prephenate dehydrogenase Sdel_0231 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Sdel_0233 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding Sdel_0235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Sdel_0237 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Sdel_0239 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Sdel_0240 ENOG4105D00 flagellar biosynthetic protein flhB Sdel_0242 ENOG4108K5P (LipO)protein Sdel_0243 ENOG4105VQJ septum formation inhibitor Sdel_0246 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) Sdel_0250 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) Sdel_0251 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Sdel_0255 ENOG4105VEQ Cold shock protein Sdel_0256 ENOG4105BZU Histidine kinase Sdel_0257 ENOG4105XJC Two component transcriptional regulator (Winged helix family Sdel_0259 ENOG4105NQN cytochrome C Sdel_0261 ENOG4105N5T Radical SAM Protein Sdel_0262 ENOG4105C8Q Methyl-accepting chemotaxis Sdel_0263 ENOG4105M5K heptosyltransferase Sdel_0264 ENOG4108UW5 maltose o-acetyltransferase Sdel_0265 ENOG4107QY8 reductase Sdel_0266 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Sdel_0267 ENOG4105DVI reductase, NrfD Sdel_0268 ENOG4105BZU Histidine kinase Sdel_0269 ENOG4108J2R molybdopterin oxidoreductase Sdel_0270 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Sdel_0271 ENOG4105DVI reductase, NrfD Sdel_0272 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Sdel_0273 ENOG4105BZU Histidine kinase Sdel_0275 ENOG4105CSA Coproporphyrinogen iii oxidase Sdel_0276 ENOG4105VCH membrane Sdel_0278 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase Sdel_0281 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Sdel_0282 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) Sdel_0283 ENOG4107RDF Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Sdel_0284 ENOG4105DUM transcriptional regulator, lysR family Sdel_0285 ENOG4105HMI Membrane Sdel_0287 ENOG4108JYZ YitT family Sdel_0289 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Sdel_0290 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Sdel_0291 ENOG4105DC7 peptidase M24 Sdel_0292 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Sdel_0293 ENOG4105FZW flagellar biosynthesis regulator FlhF Sdel_0294 ENOG4107R21 site-determining protein Sdel_0296 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Sdel_0297 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Sdel_0298 ENOG4105DD5 Flagellar motor switch protein Sdel_0299 ENOG4108URH decarboxylase Sdel_0301 ENOG4105CKK Glycosyl transferase, family 2 Sdel_0303 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Sdel_0307 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Sdel_0308 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Sdel_0309 ENOG4107VCP Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Sdel_0316 ENOG41082XB radical SAM domain protein Sdel_0317 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Sdel_0319 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Sdel_0325 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Sdel_0326 ENOG4105CD3 dihydroorotase Sdel_0327 ENOG4105CXT aspartate transcarbamylase Sdel_0330 ENOG4105BZU Histidine kinase Sdel_0335 ENOG4105K63 Thioredoxin Sdel_0337 ENOG4105CFM UPF0317 protein Sdel_0341 ENOG4105VYA Uncharacterized conserved protein (DUF2132) Sdel_0342 ENOG4105EMU Dehydrogenase Sdel_0344 ENOG410802Z Protein of unknown function (DUF328) Sdel_0345 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Sdel_0348 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) Sdel_0349 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Sdel_0352 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Sdel_0355 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Sdel_0356 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Sdel_0358 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Sdel_0359 ENOG4108UMI ABC transporter, permease Sdel_0360 ENOG4105D01 (LipO)protein Sdel_0361 ENOG4108J2R molybdopterin oxidoreductase Sdel_0363 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Sdel_0364 ENOG4105DEF Extracellular solute-binding protein, family 5 Sdel_0367 ENOG4105C8Q Methyl-accepting chemotaxis Sdel_0368 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor Sdel_0372 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Sdel_0376 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) Sdel_0377 ENOG4108N3W hemolysin secretion protein Sdel_0379 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) Sdel_0380 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) Sdel_0381 ENOG4105D52 delta-aminolevulinic acid dehydratase Sdel_0382 ENOG4105DBV ornithine carbamoyltransferase Sdel_0383 ENOG4105T1H UPF0763 protein Sdel_0384 ENOG4105D4P Coproporphyrinogen iii oxidase Sdel_0388 ENOG4107SHS Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity) Sdel_0389 ENOG4105K5B UPF0225 protein Sdel_0390 ENOG4107RU9 Transcriptional regulator, Crp Fnr family Sdel_0392 ENOG4105BZU Histidine kinase Sdel_0393 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Sdel_0394 ENOG4108S24 Fumarate reduCtase Sdel_0395 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) Sdel_0396 ENOG4105E33 succinate dehydrogenase Sdel_0398 ENOG410890F Dynamin family Sdel_0399 ENOG4105F4G Membrane Sdel_0400 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Sdel_0401 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Sdel_0403 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Sdel_0405 ENOG410903C (LipO)protein Sdel_0406 ENOG4105CE9 30S ribosomal protein S2 Sdel_0409 ENOG4105D19 Role in flagellar biosynthesis (By similarity) Sdel_0411 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Sdel_0413 ENOG4105C75 arginyL-tRNA synthetase Sdel_0415 ENOG4105BZU Histidine kinase Sdel_0419 ENOG4105CA0 peroxidase Sdel_0420 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Sdel_0423 ENOG4105CP7 Triose-phosphate isomerase Sdel_0424 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH Sdel_0427 ENOG4105CHV Transcription elongation factor NusA Sdel_0429 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Sdel_0435 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) Sdel_0436 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Sdel_0437 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) Sdel_0442 ENOG4107QMP dna polymerase iii subunits gamma and tau Sdel_0443 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Sdel_0444 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Sdel_0445 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Sdel_0446 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter Sdel_0447 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Sdel_0448 ENOG4107VQW regulatoR Sdel_0449 ENOG4105BZU Histidine kinase Sdel_0451 ENOG4105DFP Integrase Sdel_0460 ENOG4107R3N Filamentation induced by cAMP protein fic Sdel_0463 ENOG4105DDY UPF0142 protein ycaO Sdel_0464 ENOG4105C6Z Gluconate Sdel_0465 ENOG4105C1J atp-dependent rna helicase Sdel_0467 ENOG4105BZU Histidine kinase Sdel_0468 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) Sdel_0476 ENOG4105C32 Amino acid ABC transporter (Permease) Sdel_0477 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Sdel_0478 ENOG4105C0Z ABC transporter Sdel_0479 ENOG4108IV0 ABC, transporter Sdel_0480 ENOG4105CRE cytochrome C Sdel_0482 ENOG4105CEV competence damage-inducible protein Sdel_0483 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Sdel_0485 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Sdel_0486 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Sdel_0487 ENOG4105DWV Homoserine O-trans-acetylase Sdel_0490 ENOG4105D06 uba thif-type nad fad binding protein Sdel_0491 ENOG4105CHM Aminotransferase Sdel_0492 ENOG4105DFU Cell wall formation (By similarity) Sdel_0494 ENOG4105C98 muts2 protein Sdel_0495 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Sdel_0496 ENOG4105KME endoribonuclease L-psp Sdel_0497 ENOG4107RSR Malate quinone oxidoreductase Sdel_0501 ENOG4105CA9 Pyruvate kinase Sdel_0503 ENOG4105K46 50S ribosomal protein l27 Sdel_0504 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Sdel_0505 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Sdel_0506 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Sdel_0508 ENOG4107QJE Chromosome Partitioning Protein Sdel_0509 ENOG4105FA0 parb-like partition protein Sdel_0511 ENOG4105YF2 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) Sdel_0512 ENOG4105PQH F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Sdel_0513 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Sdel_0514 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Sdel_0515 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Sdel_0517 ENOG4105E02 MotA TolQ exbB proton channel Sdel_0518 ENOG4105M8F Biopolymer transport protein exbD tolR Sdel_0520 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) Sdel_0521 ENOG4105UYK outer membrane protein a Sdel_0523 ENOG4108YZY peptidylprolyl cis-trans isomerase Sdel_0525 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Sdel_0526 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) Sdel_0527 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Sdel_0529 ENOG4105CBC glutamate synthase Sdel_0530 ENOG4105BZ8 glutamate synthase Sdel_0532 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) Sdel_0533 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) Sdel_0534 ENOG4105SCY DNAK suppressor Sdel_0536 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Sdel_0540 ENOG4105DD5 Flagellar motor switch protein Sdel_0541 ENOG4105CGK Exodeoxyribonuclease III Sdel_0544 ENOG4105K56 Transcriptional regulator Sdel_0550 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) Sdel_0552 ENOG4105C85 amino acid Sdel_0553 ENOG4105HF0 Membrane Sdel_0554 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Sdel_0555 ENOG4105CK2 sodium dicarboxylate symporter Sdel_0556 ENOG4105CK2 sodium dicarboxylate symporter Sdel_0558 ENOG4105C2M dna polymerase I Sdel_0559 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) Sdel_0562 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Sdel_0564 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Sdel_0565 ENOG410804D Sensor Signal Transduction Histidine Kinase Sdel_0566 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Sdel_0568 ENOG4105BZU Histidine kinase Sdel_0570 ENOG4105CEY Amp-dependent synthetase and ligase Sdel_0571 ENOG4105E2X shikimate dehydrogenase Sdel_0572 ENOG4105CRQ synthase (Component I) Sdel_0575 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Sdel_0576 ENOG4105CRK lysyL-tRNA synthetase Sdel_0579 ENOG4105BZU Histidine kinase Sdel_0580 ENOG4105CZX twitching motility protein Sdel_0581 ENOG410855J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Sdel_0583 ENOG4108TX7 Sdel_0586 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Sdel_0587 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Sdel_0588 ENOG4105BZU Histidine kinase Sdel_0591 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Sdel_0593 ENOG4108IYU L-aspartate oxidase Sdel_0594 ENOG4105DN9 Na H antiporter Sdel_0595 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Sdel_0597 ENOG4105C12 Phosphoribosylglycinamide synthetase Sdel_0599 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) Sdel_0600 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Sdel_0604 ENOG4105PV1 biotin lipoyl attachment domaiN-containing protein Sdel_0605 ENOG4105D9Q decarboxylase (Beta subunit) Sdel_0606 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase Sdel_0607 ENOG4105CH7 arginosuccinase Sdel_0609 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Sdel_0610 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Sdel_0611 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Sdel_0612 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Sdel_0613 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Sdel_0615 ENOG4108JQ1 Dehydrogenase Sdel_0618 ENOG4107KET secretion protein, HlyD family Sdel_0624 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Sdel_0627 ENOG4105CBX hi0933 family Sdel_0628 ENOG4108YXA Membrane Sdel_0631 ENOG4105C8Q Methyl-accepting chemotaxis Sdel_0632 ENOG4105C0B DNA polymerase III (alpha subunit) Sdel_0633 ENOG4105BZU Histidine kinase Sdel_0635 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) Sdel_0636 ENOG4105C1A potassium transporter peripheral membrane Sdel_0638 ENOG4105CNI cell division protein FtsW Sdel_0639 ENOG4105C34 Pseudouridine synthase Sdel_0640 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Sdel_0641 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Sdel_0646 ENOG410692R Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) Sdel_0647 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Sdel_0648 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Sdel_0649 ENOG4105EA8 2-Nitropropane dioxygenase Sdel_0650 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase Sdel_0652 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Sdel_0653 ENOG4105C9M aspartyl-trna synthetase Sdel_0655 ENOG4105BZU Histidine kinase Sdel_0657 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Sdel_0658 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Sdel_0659 ENOG4105BZU Histidine kinase Sdel_0660 ENOG4105F8V Hydrolase, tatD family Sdel_0661 ENOG4105VRS hydrolase family 18 Sdel_0662 ENOG4105K6T rare lipoprotein A Sdel_0663 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Sdel_0664 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase Sdel_0670 ENOG4105CJN penicillin-binding protein Sdel_0671 ENOG41080V7 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Sdel_0673 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Sdel_0675 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 Sdel_0680 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Sdel_0681 ENOG4105CX6 glutaminyL-tRNA synthetase Sdel_0685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Sdel_0686 ENOG4107QPK )-transporter Sdel_0690 ENOG4105D5K Hemolysin activator protein Sdel_0694 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Sdel_0699 ENOG4105CRE cytochrome C Sdel_0700 ENOG4105DVI reductase, NrfD Sdel_0701 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Sdel_0702 ENOG4108V1T peptidylprolyl cis-trans isomerase Sdel_0703 ENOG4105V2T cytochrome C Sdel_0704 ENOG4105BZU Histidine kinase Sdel_0705 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Sdel_0706 ENOG4108W6G cytochrome C Sdel_0707 ENOG4105EAU Plays a role in nitrite reduction (By similarity) Sdel_0708 ENOG4105CRE cytochrome C Sdel_0713 ENOG41067MG lrgb family Sdel_0714 ENOG4105VAW lrga family Sdel_0717 ENOG4105M15 transport protein ExbD Sdel_0718 ENOG4105M8K biopolymer transport protein Sdel_0724 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Sdel_0725 ENOG4108BGM Quinol dehydrogenase periplasmic component Sdel_0726 ENOG4105GXZ Ferredoxin-type protein NapH Sdel_0727 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) Sdel_0728 ENOG4108ZNS ferredoxin-type protein NapF Sdel_0731 ENOG4105C3G gtp-binding protein Sdel_0735 ENOG4105BZU Histidine kinase Sdel_0738 ENOG4108J2R molybdopterin oxidoreductase Sdel_0740 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Sdel_0741 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Sdel_0742 ENOG4105EIX cytochrome c1 Sdel_0743 ENOG4105XJC Two component transcriptional regulator (Winged helix family Sdel_0744 ENOG4105BZU Histidine kinase Sdel_0745 ENOG4105CH2 amidohydrolase Sdel_0746 ENOG4105CE7 Amidase, hydantoinase carbamoylase family Sdel_0748 ENOG4105BZU Histidine kinase Sdel_0749 ENOG4105DJ4 phosphatidylserine decarboxylase Sdel_0750 ENOG4105C1J atp-dependent rna helicase Sdel_0752 ENOG4105CDY transcriptional regulatory protein Sdel_0755 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Sdel_0756 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Sdel_0757 ENOG4105DFP Integrase Sdel_0778 ENOG4105F5W AtP-binding protein Sdel_0782 ENOG4105K4U addiction module toxin, RelE StbE family Sdel_0789 ENOG4108RH0 Crea protein Sdel_0792 ENOG4105BZU Histidine kinase Sdel_0793 ENOG4108JJA ABC, transporter Sdel_0794 ENOG4105C42 Type I secretion membrane fusion protein (HlyD Sdel_0795 ENOG4108VB1 regulatoR Sdel_0799 ENOG4105DWK Membrane Sdel_0801 ENOG4105C59 p-type ATPase Sdel_0807 ENOG4105QAX Iron-sulfur Sdel_0810 ENOG4105F4R Transcriptional regulator mode Sdel_0812 ENOG4105WMR Protein CrcB homolog Sdel_0814 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) Sdel_0815 ENOG4105EHG Permease protein Sdel_0817 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Sdel_0818 ENOG4107SDU Methyl-accepting chemotaxis Sdel_0819 ENOG4105C8Q Methyl-accepting chemotaxis Sdel_0820 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Sdel_0823 ENOG410829K Lysine exporter protein (Lyse ygga) Sdel_0824 ENOG410631K Membrane Sdel_0828 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) Sdel_0831 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) Sdel_0833 ENOG4105D0M Protease HtpX homolog Sdel_0835 ENOG4105BZU Histidine kinase Sdel_0836 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Sdel_0837 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Sdel_0838 ENOG4108VD1 dedA family Sdel_0839 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Sdel_0840 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Sdel_0842 ENOG4108YZG isomerase Sdel_0843 ENOG4108Z4T Peptidase M50 Sdel_0844 ENOG4105C3F Signal peptidase i Sdel_0845 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Sdel_0847 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Sdel_0850 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) Sdel_0852 ENOG4105CB5 ATP-dependent DNA helicase recG Sdel_0858 ENOG410821Z Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) Sdel_0859 ENOG410901F (LipO)protein Sdel_0860 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Sdel_0861 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Sdel_0862 ENOG4108UUM single-stranded DNA-binding protein Sdel_0864 ENOG4108VMB DNA polymerase III subunit delta' Sdel_0865 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Sdel_0868 ENOG4107QMS site-determining protein Sdel_0869 ENOG41084TB Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) Sdel_0873 ENOG4105GSH Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Sdel_0874 ENOG4105EN6 Membrane Sdel_0875 ENOG4105C8Y Acetylornithine aminotransferase Sdel_0878 ENOG410829W Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Sdel_0879 ENOG4105X6C Flagellar basal body-associated protein FliL Sdel_0880 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Sdel_0881 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Sdel_0882 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Sdel_0884 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) Sdel_0885 ENOG4105BZ1 (ABC) transporter Sdel_0890 ENOG4105C09 Bile acid Sdel_0891 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Sdel_0892 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Sdel_0893 ENOG4105BZU Histidine kinase Sdel_0896 ENOG4108Z66 YbaK ebsC protein Sdel_0903 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Sdel_0912 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Sdel_0913 ENOG4105BZU Histidine kinase Sdel_0919 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Sdel_0948 ENOG4107WZZ SMC domain protein Sdel_0966 ENOG4105VTR Integrase Sdel_0967 ENOG410841J DNA-binding protein Hu Sdel_0969 ENOG4105CNU cell division protein FtsK Sdel_0970 ENOG4107QIJ Aconitate hydratase 2 Sdel_0971 ENOG4108YZY peptidylprolyl cis-trans isomerase Sdel_0972 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Sdel_0975 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Sdel_0976 ENOG4107Z3H Transcriptional regulator, TetR family Sdel_0982 ENOG4105C8Q Methyl-accepting chemotaxis Sdel_0983 ENOG4105C42 Type I secretion membrane fusion protein (HlyD Sdel_0984 ENOG4108JJA ABC, transporter Sdel_1014 ENOG4105C7B Threonine dehydratase Sdel_1015 ENOG4105K4P CoA-binding domain protein Sdel_1016 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Sdel_1022 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Sdel_1023 ENOG4108IUZ ABC transporter Sdel_1024 ENOG4105K8N protein family UPF0079, ATPase Sdel_1025 ENOG4107S1N anthranilate phosphoribosyltransferase Sdel_1026 ENOG410854I s4 domain protein Sdel_1027 ENOG4105CDH Citrulline--aspartate ligase Sdel_1030 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) Sdel_1031 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) Sdel_1032 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Sdel_1036 ENOG4105K44 type iii secretion Sdel_1039 ENOG4107QHF type ii secretion system protein e Sdel_1040 ENOG4105D7Q type ii secretion system Sdel_1044 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Sdel_1045 ENOG4105C6K Malic enzyme Sdel_1046 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) Sdel_1047 ENOG410855V Acylphosphatase Sdel_1048 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Sdel_1050 ENOG4105CPF Cell wall formation (By similarity) Sdel_1051 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Sdel_1053 ENOG4105CJR Integral membrane protein (MviN Sdel_1054 ENOG4105C8N cysteinyl-tRNA synthetase Sdel_1055 ENOG4105BZ1 (ABC) transporter Sdel_1056 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Sdel_1058 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Sdel_1059 ENOG4105CAN Short-chain dehydrogenase reductase Sdr Sdel_1060 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Sdel_1061 ENOG4105DZP Membrane-associated zinc metalloprotease Sdel_1062 ENOG4105DFA alanine racemase domain protein Sdel_1063 ENOG4105BZU Histidine kinase Sdel_1066 ENOG41081FY multiple antibiotic resistance (MarC)-related Sdel_1067 ENOG4105CK2 sodium dicarboxylate symporter Sdel_1068 ENOG4105D3Y Na H antiporter Sdel_1069 ENOG4107QRI Phosphoketolase Sdel_1070 ENOG4105KVH Transcriptional regulator Sdel_1071 ENOG4105NF4 modulator of drug activity Sdel_1072 ENOG4108DBC nitroreductase Sdel_1073 ENOG4105C8Q Methyl-accepting chemotaxis Sdel_1082 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) Sdel_1083 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein Sdel_1086 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha Sdel_1087 ENOG4105CMV Succinyl-CoA synthetase subunit beta Sdel_1088 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Sdel_1094 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) Sdel_1095 ENOG4105C45 hydrogenase expression formation protein (HypE) Sdel_1096 ENOG4105CQS hydrogenase expression formation protein HypD Sdel_1097 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF Sdel_1098 ENOG4107RSS Hydrogenase accessory protein HypB Sdel_1100 ENOG4105MRR Transcriptional regulator (By similarity) Sdel_1102 ENOG4108P97 Sdel_1103 ENOG4108USZ hydrogenase Sdel_1104 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit Sdel_1105 ENOG4105DPX Hydrogenase, large subunit Sdel_1106 ENOG4105E3S small subunit Sdel_1108 ENOG4107QP8 phosphohexose isomerase Sdel_1109 ENOG4105CCT upf0313 protein Sdel_1112 ENOG4105VTR Integrase Sdel_1122 ENOG4105CN7 Flagellar biosynthetic protein FliP Sdel_1123 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Sdel_1124 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Sdel_1129 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) Sdel_1134 ENOG4107WJT it plays a direct role in the translocation of protons across the membrane (By similarity) Sdel_1135 ENOG4105VSH 4-oxalocrotonate tautomerase Sdel_1136 ENOG4105CHH sulfate transporter Sdel_1138 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Sdel_1142 ENOG4105YKR Sdel_1143 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) Sdel_1144 ENOG4106H78 methyltransferase Sdel_1147 ENOG4107TPX flagellar hook-associated Sdel_1154 ENOG4108RCM Nitroreductase Sdel_1157 ENOG4107QW4 alcohol dehydrogenase Sdel_1160 ENOG4107RTG Major Facilitator superfamily Sdel_1162 ENOG4105ENX hydrolase Sdel_1163 ENOG4105CF7 AraC family transcriptional regulator Sdel_1164 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Sdel_1169 ENOG4108SEK ompa motb domain protein Sdel_1170 ENOG4105C5H ABC transporter Sdel_1173 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Sdel_1174 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) Sdel_1175 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase Sdel_1178 ENOG4107RB3 L-asparaginase Sdel_1180 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Sdel_1181 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) Sdel_1182 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Sdel_1186 ENOG4105D22 carbon starvation protein Sdel_1187 ENOG4105VCD cytoplasmic protein Sdel_1188 ENOG4105CKI cobalamin synthesis protein Sdel_1189 ENOG4105CHM Aminotransferase Sdel_1194 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit Sdel_1196 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Sdel_1197 ENOG4108HM5 NADH-ubiquinone oxidoreductase chain 49kDa Sdel_1198 ENOG4108XIB electron transport protein ysaA Sdel_1200 ENOG4105BZ8 glutamate synthase Sdel_1201 ENOG4108JQ1 Dehydrogenase Sdel_1205 ENOG4105C8Q Methyl-accepting chemotaxis Sdel_1211 ENOG4105BZU Histidine kinase Sdel_1213 ENOG4108VKG metal-dependent hydrolase Sdel_1219 ENOG4105F4G Membrane Sdel_1222 ENOG4105CJ1 ABC, transporter Sdel_1223 ENOG4107RAN Peptidase, M16 Sdel_1227 ENOG4105BZU Histidine kinase Sdel_1228 ENOG4108R96 Methyltransferase, YaeB family Sdel_1230 ENOG4108J5H Homocysteine s-methyltransferase Sdel_1234 ENOG4105BZU Histidine kinase Sdel_1235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Sdel_1236 ENOG4108UN4 phage SPO1 DNA polymerase-related protein Sdel_1238 ENOG4107YD3 Thioesterase Sdel_1239 ENOG4105VTR Integrase Sdel_1262 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Sdel_1263 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Sdel_1265 ENOG4105D49 3-dehydroquinate synthase Sdel_1268 ENOG4108EU4 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Sdel_1270 ENOG4105CVJ phosphoglycerate mutase Sdel_1273 ENOG4105BZU Histidine kinase Sdel_1274 ENOG4107QPK )-transporter Sdel_1276 ENOG4107GFK fumarate Sdel_1277 ENOG4105QUH Domain of unknown function (DUF2088) Sdel_1278 ENOG4105C8M UPF0272 protein Sdel_1280 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase Sdel_1282 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Sdel_1283 ENOG4105CVM Molybdenum cofactor synthesis domain protein Sdel_1285 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Sdel_1286 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Sdel_1287 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Sdel_1288 ENOG4105CUT histidyl-tRNA synthetase Sdel_1289 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) Sdel_1290 ENOG4105D7W serine acetyltransferase Sdel_1294 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Sdel_1295 ENOG4108ZP8 Acetolactate synthase small subunit Sdel_1296 ENOG4105C7K acetolactate synthase Sdel_1298 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase Sdel_1302 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) Sdel_1303 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) Sdel_1304 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) Sdel_1306 ENOG4105DK0 Indole-3-glycerol phosphate synthase Sdel_1308 ENOG4105QTX Pfam:UPF0153 Sdel_1311 ENOG4105CAY ferredoxin--nadp reductase Sdel_1312 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Sdel_1313 ENOG4105C3U ABC transporter Sdel_1314 ENOG4107T5V SNARE associated Golgi Sdel_1315 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase Sdel_1316 ENOG4107SDU Methyl-accepting chemotaxis Sdel_1319 ENOG4108RAC Rubrerythrin Sdel_1321 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) Sdel_1322 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Sdel_1324 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 Sdel_1325 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Sdel_1326 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Sdel_1327 ENOG4105EAH synthase Sdel_1332 ENOG4105C6T cysteine synthase Sdel_1333 ENOG4105BZU Histidine kinase Sdel_1334 ENOG4108V06 Glutathione peroxidase Sdel_1335 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Sdel_1336 ENOG4108RIR Molybdenum cofactor biosynthesis protein Sdel_1337 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Sdel_1339 ENOG4105D2N Aldolase Sdel_1340 ENOG4105EIN peptidylprolyl cis-trans isomerase Sdel_1341 ENOG4105CSM endonuclease III Sdel_1343 ENOG4105CIN aminoacyl-histidine dipeptidase Sdel_1345 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) Sdel_1346 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) Sdel_1348 ENOG4105C4K Nad synthetase Sdel_1349 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Sdel_1350 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) Sdel_1351 ENOG4105CAS nag kinase Sdel_1352 ENOG4107QID Threonine synthase Sdel_1353 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) Sdel_1355 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) Sdel_1356 ENOG4105CSR polyphosphate kinase 2 Sdel_1357 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Sdel_1358 ENOG4105CFG Acts as a chaperone (By similarity) Sdel_1359 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Sdel_1360 ENOG4108122 heat-inducible transcription repressor Sdel_1363 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Sdel_1364 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family Sdel_1365 ENOG4105D7B Flagellar biosynthesis protein flha Sdel_1366 ENOG4108KA0 Inherit from COG: Phosphoesterase, DHHA1 Sdel_1368 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) Sdel_1371 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Sdel_1372 ENOG4105EJ9 Membrane Sdel_1374 ENOG4105EEI dihydropteroate synthase Sdel_1377 ENOG4105CFH Aspartokinase Sdel_1378 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Sdel_1379 ENOG4105CSA Coproporphyrinogen iii oxidase Sdel_1380 ENOG4105CKD glutathione-regulated potassium-efflux system protein Sdel_1381 ENOG4105KNI merR family transcriptional Regulator Sdel_1382 ENOG4105DVC DnaJ domain protein Sdel_1383 ENOG4105C0H protease Sdel_1384 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Sdel_1385 ENOG4105BZU Histidine kinase Sdel_1388 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Sdel_1390 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Sdel_1393 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Sdel_1394 ENOG4108512 Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Sdel_1396 ENOG4105VG0 50S ribosomal protein l34 Sdel_1400 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Sdel_1401 ENOG4105CN1 protease Sdel_1403 ENOG4105VR9 phosphoribosylformylglycinamidine synthase Sdel_1404 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Sdel_1406 ENOG4105E9Q Acyl-transferase Sdel_1407 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Sdel_1408 ENOG4106H3A restriction Sdel_1409 ENOG4105C7Z Conserved Protein Sdel_1416 ENOG4107QUV Domain protein Sdel_1419 ENOG4105DB4 Sdel_1422 ENOG4105CGY Dna recombination protein Sdel_1424 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Sdel_1425 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Sdel_1427 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Sdel_1428 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Sdel_1431 ENOG4105D0M Protease HtpX homolog Sdel_1433 ENOG4105C5H ABC transporter Sdel_1434 ENOG4105C8Q Methyl-accepting chemotaxis Sdel_1435 ENOG4105VG1 fes assembly suf system protein Sdel_1438 ENOG4105DC1 bifunctional purine biosynthesis protein purh Sdel_1439 ENOG4105KVY Required for disulfide bond formation in some proteins (By similarity) Sdel_1440 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Sdel_1443 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Sdel_1444 ENOG4107EFR Flavocytochrome c Sdel_1447 ENOG4105C87 Aminotransferase class I and II Sdel_1450 ENOG4107QIK phosphoribosylformylglycinamidine synthase Sdel_1451 ENOG4105BZU Histidine kinase Sdel_1453 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Sdel_1454 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) Sdel_1456 ENOG4105CY0 Metallo-Beta-Lactamase Sdel_1457 ENOG4108IQE Amp-dependent synthetase and ligase Sdel_1459 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Sdel_1460 ENOG4105C08 Histidine kinase Sdel_1461 ENOG4105EEX Two component transcriptional regulator (Winged helix family Sdel_1462 ENOG4105CZN Potassium uptake protein Sdel_1463 ENOG4107ZYR domain protein Sdel_1464 ENOG4105E0X reductase Sdel_1467 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase Sdel_1468 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family Sdel_1469 ENOG4105DZS Phenylacetate-CoA ligase Sdel_1470 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E Sdel_1476 ENOG4105BZU Histidine kinase Sdel_1480 ENOG4105D7X high-affinity nickel-transporter Sdel_1481 ENOG4105ZAI Sdel_1486 ENOG4105F5P DNA-damage-inducible protein d Sdel_1487 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Sdel_1490 ENOG4105CP9 extracellular ligand-binding receptor Sdel_1491 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer Sdel_1492 ENOG4107RES phosphoglycerol transferase I Sdel_1493 ENOG4105BZU Histidine kinase Sdel_1494 ENOG4108YZA Nitrogen regulatory protein pii Sdel_1508 ENOG4105NBK UPF0345 protein Sdel_1509 ENOG4105CBX hi0933 family Sdel_1511 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Sdel_1512 ENOG4105CIY formyltetrahydrofolate deformylase Sdel_1513 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Sdel_1516 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Sdel_1517 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Sdel_1523 ENOG4105KRQ Addiction module toxin, Txe YoeB family Sdel_1525 ENOG4105FE9 pseudouridine synthase Sdel_1526 ENOG4105DKW ABC transporter Sdel_1527 ENOG41085FC arsR family transcriptional regulator Sdel_1529 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) Sdel_1530 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) Sdel_1531 ENOG4108HED Type II restriction Sdel_1533 ENOG4108U5N UPF0316 protein Sdel_1535 ENOG4105C9U ATP-dependent DNA helicase RecQ Sdel_1538 ENOG4105C1J atp-dependent rna helicase Sdel_1540 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA Sdel_1542 ENOG4108UMN azlc family Sdel_1544 ENOG4105CGA flagellar basal-body rod protein FlgG Sdel_1545 ENOG4105CGA flagellar basal-body rod protein FlgG Sdel_1546 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Sdel_1549 ENOG4108RMU ferritin dps family protein Sdel_1553 ENOG4105CE1 Ferrous iron transport protein b Sdel_1554 ENOG4105XFK Ferrous iron transport protein A Sdel_1557 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Sdel_1559 ENOG4105D05 Receptor Sdel_1561 ENOG4105D05 Receptor Sdel_1564 ENOG4107ENK receptor Sdel_1568 ENOG4105M15 transport protein ExbD Sdel_1569 ENOG4105M8K biopolymer transport protein Sdel_1572 ENOG4105BZ1 (ABC) transporter Sdel_1574 ENOG4107ZSV Receptor Sdel_1576 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Sdel_1577 ENOG4107QN1 sodium solute Sdel_1578 ENOG41062QD Membrane Sdel_1579 ENOG4108STX response regulator Sdel_1580 ENOG4105ES5 Histidine kinase Sdel_1583 ENOG4105CE1 Ferrous iron transport protein b Sdel_1584 ENOG4107K9B ferrous iron transport protein Sdel_1588 ENOG4107VIJ nudix hydrolase Sdel_1589 ENOG4105D7N magnesium and cobalt transport protein CorA Sdel_1590 ENOG4105DR5 peptidase Sdel_1592 ENOG4105CQB FAD linked oxidase domain protein Sdel_1593 ENOG4107S2Z UPF0761 membrane protein Sdel_1595 ENOG4105CDU Replicative dna helicase Sdel_1596 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Sdel_1597 ENOG4105C25 Primosomal protein n' Sdel_1602 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Sdel_1604 ENOG4108Z0R Transferase Sdel_1605 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) Sdel_1606 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase Sdel_1607 ENOG4105DJV ribulose-phosphate 3-epimerase Sdel_1608 ENOG4105VB9 50S ribosomal protein l28 Sdel_1609 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Sdel_1612 ENOG4105D48 metallophosphoesterase Sdel_1613 ENOG4108JA2 transcriptioN-repair coupling factor Sdel_1615 ENOG4105DR5 peptidase Sdel_1616 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Sdel_1619 ENOG4105C8T Leucyl-tRNA synthetase Sdel_1620 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Sdel_1621 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Sdel_1622 ENOG4105VIE preprotein translocase, subunit YajC Sdel_1624 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Sdel_1625 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) Sdel_1626 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Sdel_1627 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) Sdel_1629 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Sdel_1630 ENOG4107Z7S Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Sdel_1631 ENOG41085EF Carbon storage regulator Sdel_1632 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Sdel_1634 ENOG4105DUM transcriptional regulator, lysR family Sdel_1638 ENOG4105CRQ synthase (Component I) Sdel_1640 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) Sdel_1645 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Sdel_1646 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Sdel_1647 ENOG4105V3S An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Sdel_1648 ENOG4105VB6 UPF0109 protein Sdel_1650 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY Sdel_1651 ENOG4105EI2 Pseudouridine synthase Sdel_1652 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase Sdel_1654 ENOG4105EGD dinuclear metal center protein, YbgI family Sdel_1655 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit Sdel_1657 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Sdel_1658 ENOG4105CFP Peptidase U32 Sdel_1660 ENOG4107RVV histidinol phosphate phosphatase, hisj family Sdel_1661 ENOG4105C5F glutamine synthetase Sdel_1662 ENOG4108JQC penicillin-binding protein 1A Sdel_1664 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Sdel_1665 ENOG4107YJQ MAF-like protein Sdel_1667 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Sdel_1670 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Sdel_1671 ENOG4105CJN penicillin-binding protein Sdel_1673 ENOG4108ZC9 flagellar basal-body rod protein flgc Sdel_1674 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Sdel_1675 ENOG4105CNI cell division protein FtsW Sdel_1678 ENOG4105KQC Competence protein Sdel_1681 ENOG4105DDQ anthranilate synthase Sdel_1682 ENOG4105BZU Histidine kinase Sdel_1685 ENOG4105C7N Xanthine uracil vitamin C permease Sdel_1686 ENOG4105DVY radical SAM domain protein Sdel_1687 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Sdel_1688 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) Sdel_1689 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Sdel_1696 ENOG4105C5H ABC transporter Sdel_1697 ENOG4105BZU Histidine kinase Sdel_1702 ENOG4105CUZ uba thif-type nad fad binding protein Sdel_1703 ENOG4105BZU Histidine kinase Sdel_1705 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) Sdel_1706 ENOG4105D1F ATP-binding protein Sdel_1707 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Sdel_1710 ENOG4108ZAI phosphatidylglycerophosphatase a Sdel_1711 ENOG4108YYC ycei family Sdel_1712 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Sdel_1713 ENOG4108IJ9 (ABC) transporter Sdel_1716 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Sdel_1717 ENOG4105E0C molybdate abc transporter Sdel_1719 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Sdel_1720 ENOG4105DZ1 carboxypeptidase Sdel_1721 ENOG4108PPJ Type II restriction Sdel_1723 ENOG4105II7 pyrroline-5-carboxylate reductase Sdel_1724 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Sdel_1725 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Sdel_1726 ENOG4105CW7 secretion protein, HlyD family Sdel_1727 ENOG4105DFG type I secretion outer membrane protein Sdel_1734 ENOG4105C4M (Ubiquinol oxidase) subunit I Sdel_1735 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Sdel_1737 ENOG4105BZU Histidine kinase Sdel_1746 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) Sdel_1747 ENOG4105M7K Involved in the transcription termination process (By similarity) Sdel_1748 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Sdel_1749 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process Sdel_1750 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase Sdel_1751 ENOG4108JHT EamA-like transporter family Sdel_1752 ENOG4105D64 Mechanosensitive ion channel Sdel_1753 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Sdel_1755 ENOG4105C31 Tryptophanyl-tRNA synthetase Sdel_1756 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Sdel_1758 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Sdel_1759 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase Sdel_1760 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme Sdel_1761 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Sdel_1762 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Sdel_1764 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Sdel_1765 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Sdel_1769 ENOG4105C5E polysaccharide biosynthesis protein Sdel_1770 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase Sdel_1771 ENOG4105ESV Glycosyl transferase, family 4 Sdel_1773 ENOG4108RYC glycosyltransferase Sdel_1778 ENOG4105K64 Glycosyl transferase, family 2 Sdel_1785 ENOG4105C1B dTDP-glucose 4-6-dehydratase Sdel_1790 ENOG4105C0K Gdp-mannose 4,6-dehydratase Sdel_1791 ENOG4105CJT Mannose-1-phosphate guanylyltransferase Sdel_1793 ENOG4105CMR udp-glucose 4-epimerase Sdel_1797 ENOG4105C1B dTDP-glucose 4-6-dehydratase Sdel_1798 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) Sdel_1805 ENOG4105DKP glycosyl transferase, family 9 Sdel_1807 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) Sdel_1808 ENOG4105D16 lipopolysaccharide heptosyltransferase i Sdel_1812 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) Sdel_1813 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) Sdel_1814 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) Sdel_1815 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase Sdel_1819 ENOG4105C59 p-type ATPase Sdel_1820 ENOG4105BZU Histidine kinase Sdel_1821 ENOG4106AFQ Histidine kinase Sdel_1822 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) Sdel_1824 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Sdel_1826 ENOG4105C8Q Methyl-accepting chemotaxis Sdel_1827 ENOG4107R7A Allophanate hydrolase subunit 2 Sdel_1828 ENOG4105P4J Allophanate hydrolase, subunit 1 Sdel_1830 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Sdel_1831 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Sdel_1832 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Sdel_1833 ENOG4105EIX cytochrome c1 Sdel_1834 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) Sdel_1835 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Sdel_1836 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Sdel_1838 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Sdel_1840 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Sdel_1841 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Sdel_1842 ENOG4108M8H domain protein Sdel_1847 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Sdel_1850 ENOG4105CJ3 phosphate transporter Sdel_1851 ENOG4105C1J atp-dependent rna helicase Sdel_1852 ENOG4108UPT UPF0178 protein Sdel_1854 ENOG4108N3W hemolysin secretion protein Sdel_1856 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Sdel_1858 ENOG4105C8U phosphate abc transporter Sdel_1859 ENOG4105PWN phosphate abc transporter Sdel_1861 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) Sdel_1862 ENOG4108JPZ Monovalent cation H antiporter subunit D Sdel_1863 ENOG4107TDF Formate hydrogenlyase subunit 4 Sdel_1864 ENOG4107WQX hydrogenase 4 membrane subunit Sdel_1865 ENOG4108JPZ Monovalent cation H antiporter subunit D Sdel_1866 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Sdel_1868 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit Sdel_1873 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Sdel_1874 ENOG4105BZU Histidine kinase Sdel_1875 ENOG4105NAU thioesterase Superfamily protein Sdel_1876 ENOG4105CUX Signal transduction histidine kinase Sdel_1877 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) Sdel_1878 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) Sdel_1884 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Sdel_1885 ENOG4105BZS acriflavin resistance protein Sdel_1886 ENOG4105C1P efflux transporter, rnd family, mfp subunit Sdel_1889 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) Sdel_1890 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) Sdel_1894 ENOG41090EX DsrE family Sdel_1897 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Sdel_1899 ENOG4107XGZ Hydrolase Sdel_1901 ENOG4105CDV Ompa motb domain protein Sdel_1905 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR Sdel_1909 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Sdel_1910 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation Sdel_1916 ENOG4107UIK C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) Sdel_1919 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i Sdel_1921 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor Sdel_1923 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Sdel_1927 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Sdel_1928 ENOG4105CYE ATP phosphoribosyltransferase regulatory subunit Sdel_1929 ENOG4107UUH Aminotransferase Sdel_1930 ENOG4105C8Q Methyl-accepting chemotaxis Sdel_1931 ENOG4105C8Q Methyl-accepting chemotaxis Sdel_1932 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Sdel_1933 ENOG4105CV1 Transketolase (EC 2.2.1.1) Sdel_1936 ENOG41084FT Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Sdel_1937 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Sdel_1938 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Sdel_1941 ENOG4108ZT0 50S ribosomal protein l17 Sdel_1942 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Sdel_1944 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Sdel_1945 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Sdel_1946 ENOG41067V7 50S ribosomal protein L36 Sdel_1947 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Sdel_1948 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Sdel_1949 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Sdel_1950 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Sdel_1952 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Sdel_1953 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Sdel_1956 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Sdel_1958 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Sdel_1959 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Sdel_1960 ENOG41084HJ 50s ribosomal protein l29 Sdel_1963 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Sdel_1964 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Sdel_1966 ENOG4105KZZ One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Sdel_1968 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Sdel_1971 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Sdel_1973 ENOG4105CE1 Ferrous iron transport protein b Sdel_1974 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Sdel_1975 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Sdel_1976 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Sdel_1978 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Sdel_1979 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Sdel_1980 ENOG4107YTP response regulator receiver protein Sdel_1982 ENOG4105BZU Histidine kinase Sdel_1983 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Sdel_1984 ENOG4105BZU Histidine kinase Sdel_1985 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Sdel_1986 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) Sdel_1987 ENOG4105BZU Histidine kinase Sdel_1988 ENOG4105BZU Histidine kinase Sdel_1989 ENOG4105CBS Chea signal transduction histidine kinase Sdel_1991 ENOG4105C8Q Methyl-accepting chemotaxis Sdel_1992 ENOG4108V3W Chemotaxis protein, CheW Sdel_1993 ENOG4108VYJ response regulator receiver protein Sdel_1995 ENOG4107R08 Integrase Sdel_2004 ENOG4105XJC Two component transcriptional regulator (Winged helix family Sdel_2005 ENOG4105BZU Histidine kinase Sdel_2006 ENOG4105HDK L-asparaginase Sdel_2007 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter Sdel_2008 ENOG4108IJ0 Aspartate ammonia-lyase Sdel_2009 ENOG4108IJ0 Aspartate ammonia-lyase Sdel_2010 ENOG4105EWI Short-chain dehydrogenase reductase Sdr Sdel_2019 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Sdel_2020 ENOG4107RBB ABC transporter, permease Sdel_2024 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase Sdel_2026 ENOG4107SDU Methyl-accepting chemotaxis Sdel_2028 ENOG4107TUY Histidine kinase Sdel_2029 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Sdel_2030 ENOG4105VYW UPF0251 protein Sdel_2032 ENOG4107XTP (EAL) domain protein Sdel_2033 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein Sdel_2034 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Sdel_2035 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Sdel_2037 ENOG4105DIJ Phosphoethanolamine transferase Sdel_2038 ENOG4105GR3 Histidine kinase Sdel_2039 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Sdel_2041 ENOG410829K Lysine exporter protein (Lyse ygga) Sdel_2043 ENOG4105N14 lysine exporter protein LysE YggA Sdel_2047 ENOG4105D7X high-affinity nickel-transporter Sdel_2053 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) Sdel_2054 ENOG4105VFE sira family Sdel_2057 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Sdel_2058 ENOG41066FR extracellular solute-binding protein Sdel_2060 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Sdel_2063 ENOG4105E0A ABC, transporter Sdel_2064 ENOG4105EHG Permease protein Sdel_2066 ENOG4105M15 transport protein ExbD Sdel_2067 ENOG4105M8K biopolymer transport protein Sdel_2068 ENOG4105F4R Transcriptional regulator mode Sdel_2069 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Sdel_2073 ENOG4105QAX Iron-sulfur Sdel_2074 ENOG4108IEG Formate dehydrogenase Alpha subunit Sdel_2075 ENOG4108J2R molybdopterin oxidoreductase Sdel_2080 ENOG4105C08 Histidine kinase Sdel_2081 ENOG4105EEX Two component transcriptional regulator (Winged helix family Sdel_2082 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) Sdel_2083 ENOG4105EM7 Selenocysteine-specific translation elongation factor Sdel_2084 ENOG4107EFR Flavocytochrome c Sdel_2089 ENOG4107EFR Flavocytochrome c Sdel_2094 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Sdel_2095 ENOG4105E0F Histidine kinase Sdel_2097 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) Sdel_2100 ENOG4105C84 Histidine ammonia-lyase Sdel_2101 ENOG4105CHR reductase Sdel_2107 ENOG4105CJ1 ABC, transporter Sdel_2120 ENOG4108MUZ hydrolase Sdel_2123 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Sdel_2124 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Sdel_2125 ENOG4105C1J atp-dependent rna helicase Sdel_2128 ENOG4108KS2 transglutaminase domain protein Sdel_2129 ENOG4105DVP Adenine-specific Sdel_2130 ENOG4105BZU Histidine kinase Sdel_2135 ENOG4105CKI cobalamin synthesis protein Sdel_2138 ENOG4105BZU Histidine kinase Sdel_2139 ENOG4105XJC Two component transcriptional regulator (Winged helix family Sdel_2141 ENOG4105C8Q Methyl-accepting chemotaxis Sdel_2143 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Sdel_2144 ENOG4105CA3 membrane-bound lytic murein transglycosylase Sdel_2146 ENOG4107RDB Major Facilitator Sdel_2150 ENOG4105CVM Molybdenum cofactor synthesis domain protein Sdel_2151 ENOG4108ZEX molybdopterin converting factor, subunit 2 Sdel_2153 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins Sdel_2154 ENOG4105C3J Cysteine desulfurase Sdel_2155 ENOG4108JIR Flagellum-specific ATP synthase Sdel_2156 ENOG4105EUJ GTP cyclohydrolase i Sdel_2158 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Sdel_2160 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Sdel_2161 ENOG4105C0P Mg chelatase subunit ChlI Sdel_2162 ENOG4108ENG carbohydrate kinase, YjeF related protein Sdel_2163 ENOG4108V3E phosphoribosylglycinamide formyltransferase Sdel_2164 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Sdel_2168 ENOG4105EYW Ion transport protein Sdel_2172 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Sdel_2175 ENOG4105EMK carboxylate amino acid amine transporter Sdel_2178 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Sdel_2179 ENOG4105BZU Histidine kinase Sdel_2184 ENOG4108UXE Protein tyrosine phosphatase Sdel_2186 ENOG4105DFF Rod shape-determining protein mreb Sdel_2187 ENOG4105EE5 Membrane protein terC Sdel_2188 ENOG4108XUR Pfam:DUF178 Sdel_2189 ENOG4105D82 Glutamate dehydrogenase Sdel_2190 ENOG4108UYN gCN5-related N-acetyltransferase Sdel_2191 ENOG4105C3S Mate efflux family protein Sdel_2193 ENOG4105BZU Histidine kinase Sdel_2194 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Sdel_2195 ENOG4105C6K Malic enzyme Sdel_2196 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Sdel_2197 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) Sdel_2198 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Sdel_2199 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein Sdel_2200 ENOG4105DHP deoxycytidine triphosphate deaminase Sdel_2204 ENOG4105DR4 Methyltransferase Sdel_2205 ENOG4107XM9 (LipO)protein Sdel_2207 ENOG4105I03 Flagellin Sdel_2208 ENOG4105C5E polysaccharide biosynthesis protein Sdel_2209 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Sdel_2210 ENOG4105F0R Cytidylyltransferase Sdel_2212 ENOG4105VDT -acetyltransferase Sdel_2215 ENOG4108VQJ O-methyltransferase Sdel_2216 ENOG4105CAQ asparagine synthetase Sdel_2220 ENOG4108YRB methyltransferase Sdel_2222 ENOG4105C1B dTDP-glucose 4-6-dehydratase Sdel_2230 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Sdel_2231 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) Sdel_2232 ENOG4105BZN citrate synthase Sdel_2235 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Sdel_2236 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Sdel_2237 ENOG4105E63 Pfam:DUF178 Sdel_2238 ENOG4105VS8 Flagellar biosynthetic protein fliq Sdel_2239 ENOG4105D4A Cell wall formation (By similarity) Sdel_2240 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Sdel_2242 ENOG4105BZU Histidine kinase Sdel_2246 ENOG4105DIN metallophosphoesterase Sdel_2247 ENOG4105BZG amino acid carrier protein Sdel_2248 ENOG4105C2W permease Sdel_2249 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Sdel_2250 ENOG4105KNE Phosphatidate cytidylyltransferase Sdel_2253 ENOG4105BZW Glycerate kinase Sdel_2254 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Sdel_2257 ENOG4105D3R alkyl hydroperoxide reductase Sdel_2259 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Sdel_2260 ENOG41080AZ Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) Sdel_2261 ENOG4105BZU Histidine kinase Sdel_2263 ENOG4105HDD phospholipase Sdel_2264 ENOG4105VFU Rna-binding protein Sdel_2265 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Sdel_2270 ENOG4105HFZ Membrane Sdel_2275 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Sdel_2276 ENOG4108J2R molybdopterin oxidoreductase Sdel_2278 ENOG4105NU9 Preprotein translocase subunit SecG Sdel_2280 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Sdel_2281 ENOG4107VCP Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Sdel_2286 ENOG4108V0P LemA family Sdel_2287 ENOG4105CI3 gtp-binding protein typa Sdel_2289 ENOG4105W00 Flagellar hook capping protein Sdel_2290 ENOG4105BZE flagellar hook protein, FlgE Sdel_2291 ENOG4105BZE flagellar hook protein, FlgE