locus-tag	class	description
SMUL_0002	COG0592	DNA-directed DNA polymerase activity
SMUL_0003	COG0187	DNA topoisomerase II activity
SMUL_0005	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMUL_0008	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMUL_0009	COG2203	Gaf domain
SMUL_0009	COG3706	GGDEF domain
SMUL_0009	COG4251	negative regulation of phosphorylation
SMUL_0009	COG5001	Diguanylate cyclase
SMUL_0011	COG4175	Glycine betaine
SMUL_0012	COG4176	ABC-type proline glycine betaine transport system permease component
SMUL_0013	COG2113	Glycine betaine
SMUL_0014	COG2814	Major facilitator Superfamily
SMUL_0015	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SMUL_0018	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMUL_0019	COG0066	3-isopropylmalate dehydratase activity
SMUL_0027	COG2801	Transposase and inactivated derivatives
SMUL_0028	COG2963	transposase activity
SMUL_0032	COG3328	transposase activity
SMUL_0044	COG0840	transmembrane signaling receptor activity
SMUL_0049	COG2801	Transposase and inactivated derivatives
SMUL_0051	COG0745	RESPONSE REGULATOR receiver
SMUL_0052	COG3328	transposase activity
SMUL_0056	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SMUL_0059	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMUL_0060	COG1335	isochorismatase
SMUL_0063	COG2207	Transcriptional regulator
SMUL_0064	COG1053	succinate dehydrogenase
SMUL_0065	COG0039	L-malate dehydrogenase activity
SMUL_0069	COG1355	regulation of microtubule-based process
SMUL_0074	COG1917	Cupin 2, conserved barrel domain protein
SMUL_0074	COG2169	Transcriptional regulator
SMUL_0076	COG3150	esterase
SMUL_0077	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMUL_0079	COG3383	formate dehydrogenase (NAD+) activity
SMUL_0080	COG3706	GGDEF domain
SMUL_0090	COG2095	MarC family integral membrane protein
SMUL_0093	COG1120	ATPase activity
SMUL_0094	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMUL_0101	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMUL_0102	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMUL_0103	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMUL_0107	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMUL_0107	COG1328	CTP reductase activity
SMUL_0108	COG1794	racemase activity, acting on amino acids and derivatives
SMUL_0109	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMUL_0110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMUL_0111	COG0564	pseudouridine synthase activity
SMUL_0112	COG0179	Fumarylacetoacetate (FAA) hydrolase
SMUL_0113	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMUL_0115	COG0107	imidazoleglycerol-phosphate synthase activity
SMUL_0117	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SMUL_0118	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SMUL_0118	COG0517	IMP dehydrogenase activity
SMUL_0119	COG1187	pseudouridine synthase activity
SMUL_0120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMUL_0120	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SMUL_0122	COG2257	FlhB HrpN YscU SpaS Family
SMUL_0124	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMUL_0125	COG0237	dephospho-CoA kinase activity
SMUL_0126	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SMUL_0128	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMUL_0129	COG0268	Binds directly to 16S ribosomal RNA
SMUL_0132	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMUL_0133	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SMUL_0135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMUL_0136	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMUL_0137	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMUL_0138	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMUL_0139	COG0348	domain, Protein
SMUL_0144	COG0754	glutathionylspermidine amidase activity
SMUL_0147	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SMUL_0153	COG5002	protein histidine kinase activity
SMUL_0154	COG0745	RESPONSE REGULATOR receiver
SMUL_0157	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SMUL_0158	COG1127	ABC transporter
SMUL_0159	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SMUL_0161	COG2095	MarC family integral membrane protein
SMUL_0162	COG0840	transmembrane signaling receptor activity
SMUL_0162	COG3290	protein histidine kinase activity
SMUL_0164	COG0784	Response regulator, receiver
SMUL_0164	COG3437	response regulator, receiver
SMUL_0165	COG0784	Response regulator, receiver
SMUL_0165	COG3437	response regulator, receiver
SMUL_0170	COG0745	RESPONSE REGULATOR receiver
SMUL_0173	COG0004	ammonium transporteR
SMUL_0176	COG0667	Aldo Keto reductase
SMUL_0178	COG0745	RESPONSE REGULATOR receiver
SMUL_0181	COG0765	amino acid transport
SMUL_0186	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMUL_0187	COG1121	(ABC) transporter
SMUL_0191	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SMUL_0193	COG0318	PFAM AMP-dependent synthetase and ligase
SMUL_0194	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMUL_0195	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_0196	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_0197	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_0198	COG0649	NAD binding
SMUL_0202	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMUL_0203	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_0204	COG0839	Belongs to the complex I subunit 6 family
SMUL_0205	COG0713	ATP synthesis coupled electron transport
SMUL_0206	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMUL_0207	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_0208	COG1007	ATP synthesis coupled electron transport
SMUL_0213	COG1012	belongs to the aldehyde dehydrogenase family
SMUL_0214	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMUL_0218	COG0840	transmembrane signaling receptor activity
SMUL_0220	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMUL_0221	COG0303	'Molybdopterin
SMUL_0223	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SMUL_0224	COG0254	rRNA binding
SMUL_0225	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SMUL_0229	COG0436	Aminotransferase
SMUL_0230	COG0460	homoserine dehydrogenase
SMUL_0231	COG0792	nuclease activity
SMUL_0232	COG3118	belongs to the thioredoxin family
SMUL_0233	COG0492	ferredoxin-NADP+ reductase activity
SMUL_0234	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMUL_0235	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SMUL_0236	COG1242	4 iron, 4 sulfur cluster binding
SMUL_0239	COG0140	phosphoribosyl-ATP diphosphatase activity
SMUL_0239	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMUL_0242	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SMUL_0244	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMUL_0245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMUL_0246	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMUL_0247	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMUL_0248	COG1077	Cell shape determining protein MreB Mrl
SMUL_0250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMUL_0255	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SMUL_0256	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SMUL_0257	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMUL_0264	COG2963	transposase activity
SMUL_0265	COG2801	Transposase and inactivated derivatives
SMUL_0266	COG3328	transposase activity
SMUL_0267	COG2801	Transposase and inactivated derivatives
SMUL_0273	COG0437	4 iron, 4 sulfur cluster binding
SMUL_0274	COG0243	molybdopterin cofactor binding
SMUL_0277	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMUL_0278	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMUL_0280	COG0784	Response regulator, receiver
SMUL_0280	COG0835	chemotaxis
SMUL_0281	COG2198	Histidine kinase
SMUL_0281	COG0643	Histidine kinase
SMUL_0282	COG0835	chemotaxis
SMUL_0284	COG0560	Phosphoserine phosphatase
SMUL_0285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMUL_0291	COG0193	aminoacyl-tRNA hydrolase activity
SMUL_0293	COG0019	diaminopimelate decarboxylase activity
SMUL_0294	COG0077	Prephenate dehydratase
SMUL_0294	COG1605	Chorismate mutase
SMUL_0295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMUL_0297	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMUL_0299	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMUL_0301	COG0450	alkyl hydroperoxide reductase
SMUL_0302	COG0840	transmembrane signaling receptor activity
SMUL_0304	COG0105	UTP biosynthetic process
SMUL_0306	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SMUL_0307	COG0416	fatty acid biosynthetic process
SMUL_0308	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMUL_0309	COG0287	Prephenate dehydrogenase
SMUL_0310	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMUL_0311	COG0248	Ppx GppA phosphatase
SMUL_0312	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMUL_0314	COG0745	RESPONSE REGULATOR receiver
SMUL_0316	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SMUL_0318	COG0157	Belongs to the NadC ModD family
SMUL_0319	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMUL_0322	COG0850	regulation of cytokinetic process
SMUL_0323	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SMUL_0325	COG0083	homoserine kinase activity
SMUL_0329	COG0779	Required for maturation of 30S ribosomal subunits
SMUL_0330	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMUL_0330	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMUL_0332	COG5001	Diguanylate cyclase
SMUL_0333	COG1278	Cold shock
SMUL_0334	COG5002	protein histidine kinase activity
SMUL_0337	COG3258	Cytochrome c
SMUL_0339	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SMUL_0339	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMUL_0342	COG0243	molybdopterin cofactor binding
SMUL_0343	COG0437	4 iron, 4 sulfur cluster binding
SMUL_0344	COG3301	Polysulphide reductase, NrfD
SMUL_0345	COG2200	EAL domain
SMUL_0345	COG3287	FIST C domain
SMUL_0345	COG2199	diguanylate cyclase activity
SMUL_0347	COG0437	4 iron, 4 sulfur cluster binding
SMUL_0348	COG3301	Polysulphide reductase, NrfD
SMUL_0349	COG0745	RESPONSE REGULATOR receiver
SMUL_0350	COG5002	protein histidine kinase activity
SMUL_0352	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMUL_0354	COG1227	inorganic diphosphatase activity
SMUL_0358	COG1570	exodeoxyribonuclease VII activity
SMUL_0360	COG2199	diguanylate cyclase activity
SMUL_0360	COG2203	Gaf domain
SMUL_0362	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMUL_0363	COG1028	Short-chain dehydrogenase reductase Sdr
SMUL_0364	COG2207	Transcriptional regulator
SMUL_0365	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMUL_0366	COG0583	DNA-binding transcription factor activity
SMUL_0367	COG2855	membrane
SMUL_0368	COG0386	Belongs to the glutathione peroxidase family
SMUL_0372	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMUL_0374	COG0402	S-adenosylhomocysteine deaminase activity
SMUL_0375	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SMUL_0376	COG0006	proline dipeptidase activity
SMUL_0377	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SMUL_0378	COG1419	protein localization to endoplasmic reticulum
SMUL_0379	COG0455	bacterial-type flagellum organization
SMUL_0381	COG1191	sigma factor activity
SMUL_0382	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMUL_0383	COG1776	CheC inhibitor of MCP methylation
SMUL_0383	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMUL_0384	COG1611	Belongs to the LOG family
SMUL_0386	COG0463	Glycosyl transferase, family 2
SMUL_0388	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMUL_0389	COG2076	Multidrug Resistance protein
SMUL_0392	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMUL_0394	COG1040	competence protein
SMUL_0400	COG2204	response regulator
SMUL_0401	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMUL_0403	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SMUL_0404	COG0731	radical SAM domain protein
SMUL_0408	COG0582	viral genome integration into host DNA
SMUL_0412	COG3328	transposase activity
SMUL_0431	COG0419	ATPase involved in DNA repair
SMUL_0433	COG3328	transposase activity
SMUL_0438	COG0039	L-malate dehydrogenase activity
SMUL_0440	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SMUL_0441	COG1834	amidinotransferase
SMUL_0443	COG0693	protein deglycase activity
SMUL_0449	COG2199	diguanylate cyclase activity
SMUL_0449	COG3287	FIST C domain
SMUL_0449	COG2200	EAL domain
SMUL_0452	COG3118	belongs to the thioredoxin family
SMUL_0459	COG4628	conserved protein (DUF2132)
SMUL_0460	COG4221	oxidoreductase activity
SMUL_0463	COG0683	leucine binding
SMUL_0464	COG0559	Belongs to the binding-protein-dependent transport system permease family
SMUL_0467	COG0410	ABC transporter
SMUL_0468	COG1012	belongs to the aldehyde dehydrogenase family
SMUL_0471	COG3022	response to hydroperoxide
SMUL_0476	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMUL_0477	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMUL_0480	COG0250	Participates in transcription elongation, termination and antitermination
SMUL_0481	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMUL_0482	COG0081	regulation of translation
SMUL_0483	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMUL_0484	COG0222	ribosome binding
SMUL_0485	COG0085	RNA polymerase activity
SMUL_0486	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMUL_0487	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMUL_0491	COG2011	ABC-type metal ion transport system permease component
SMUL_0492	COG1464	Belongs to the NlpA lipoprotein family
SMUL_0495	COG1522	sequence-specific DNA binding
SMUL_0496	COG0697	spore germination
SMUL_0502	COG0745	RESPONSE REGULATOR receiver
SMUL_0505	COG0840	transmembrane signaling receptor activity
SMUL_0506	COG0840	transmembrane signaling receptor activity
SMUL_0508	COG1034	ATP synthesis coupled electron transport
SMUL_0509	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMUL_0510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_0511	COG0839	Belongs to the complex I subunit 6 family
SMUL_0512	COG0713	ATP synthesis coupled electron transport
SMUL_0513	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMUL_0514	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_0515	COG1007	ATP synthesis coupled electron transport
SMUL_0519	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_0519	COG0649	NAD binding
SMUL_0520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_0521	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_0524	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SMUL_0528	COG0357	Ribosomal RNA small subunit methyltransferase G
SMUL_0529	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMUL_0530	COG1970	mechanosensitive ion channel activity
SMUL_0532	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMUL_0533	COG0113	porphobilinogen synthase activity
SMUL_0534	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMUL_0536	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMUL_0537	COG0247	lactate metabolic process
SMUL_0542	COG2026	Addiction module toxin, RelE StbE family
SMUL_0543	COG3706	GGDEF domain
SMUL_0544	COG2814	Major facilitator Superfamily
SMUL_0545	COG3012	SEC-C Motif Domain Protein
SMUL_0548	COG3706	GGDEF domain
SMUL_0549	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMUL_0551	COG1053	succinate dehydrogenase
SMUL_0552	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SMUL_0554	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SMUL_0555	COG0628	permease
SMUL_0556	COG2255	four-way junction helicase activity
SMUL_0557	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SMUL_0559	COG0159	tryptophan synthase activity
SMUL_0563	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMUL_0564	COG1136	(ABC) transporter
SMUL_0565	COG1684	flagellar biosynthetic protein fliR
SMUL_0567	COG0194	GDP metabolic process
SMUL_0568	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMUL_0569	COG0018	arginyl-trna synthetase
SMUL_0571	COG2200	EAL domain
SMUL_0571	COG2199	diguanylate cyclase activity
SMUL_0571	COG3287	FIST C domain
SMUL_0574	COG0735	belongs to the Fur family
SMUL_0576	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMUL_0577	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SMUL_0579	COG0149	triose-phosphate isomerase activity
SMUL_0580	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SMUL_0583	COG0195	Participates in both transcription termination and antitermination
SMUL_0590	COG0037	tRNA processing
SMUL_0591	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMUL_0592	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SMUL_0593	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SMUL_0598	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMUL_0599	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SMUL_0600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMUL_0602	COG1151	hydroxylamine reductase activity
SMUL_0608	COG2326	polyphosphate kinase activity
SMUL_0613	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMUL_0616	COG0513	Belongs to the DEAD box helicase family
SMUL_0617	COG2610	gluconate transmembrane transporter activity
SMUL_0618	COG1944	ATP diphosphatase activity
SMUL_0620	COG4191	Histidine kinase
SMUL_0621	COG2204	response regulator
SMUL_0623	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
SMUL_0626	COG2361	Protein of unknown function DUF86
SMUL_0640	COG0559	Belongs to the binding-protein-dependent transport system permease family
SMUL_0644	COG1333	cytochrome c biogenesis protein
SMUL_0644	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMUL_0652	COG1546	Belongs to the CinA family
SMUL_0652	COG1058	Belongs to the CinA family
SMUL_0653	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMUL_0656	COG0517	IMP dehydrogenase activity
SMUL_0656	COG0516	GMP reductase activity
SMUL_0657	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SMUL_0660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SMUL_0661	COG0436	Aminotransferase
SMUL_0664	COG1193	negative regulation of DNA recombination
SMUL_0665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMUL_0666	COG0251	oxidation-reduction process
SMUL_0667	COG0579	oxidoreductase
SMUL_0670	COG0454	-acetyltransferase
SMUL_0670	COG0456	acetyltransferase
SMUL_0671	COG0793	Belongs to the peptidase S41A family
SMUL_0671	COG3409	Peptidoglycan-binding domain 1 protein
SMUL_0673	COG0469	pyruvate kinase activity
SMUL_0674	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMUL_0675	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMUL_0676	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMUL_0677	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMUL_0678	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMUL_0680	COG1192	Involved in chromosome partitioning
SMUL_0681	COG1475	DNA binding
SMUL_0683	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMUL_0684	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMUL_0686	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMUL_0689	COG0811	peptide transport
SMUL_0690	COG0848	biopolymer transport protein
SMUL_0692	COG0823	Involved in the tonB-independent uptake of proteins
SMUL_0693	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SMUL_0693	COG2885	chlorophyll binding
SMUL_0695	COG1047	Peptidyl-prolyl cis-trans
SMUL_0697	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMUL_0698	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SMUL_0699	COG0037	tRNA processing
SMUL_0701	COG0067	glutamate synthase
SMUL_0701	COG0069	glutamate synthase activity
SMUL_0701	COG0070	glutamate synthase
SMUL_0702	COG0493	'glutamate synthase
SMUL_0704	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SMUL_0705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SMUL_0706	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SMUL_0708	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMUL_0712	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMUL_0712	COG1776	CheC inhibitor of MCP methylation
SMUL_0715	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SMUL_0717	COG0748	coenzyme F420 binding
SMUL_0724	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SMUL_0727	COG1113	amino acid transport
SMUL_0728	COG0730	response to heat
SMUL_0729	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMUL_0730	COG1301	dicarboxylic acid transport
SMUL_0731	COG1301	dicarboxylic acid transport
SMUL_0733	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMUL_0733	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMUL_0734	COG1971	Probably functions as a manganese efflux pump
SMUL_0736	COG0484	heat shock protein binding
SMUL_0741	COG1271	oxidase subunit
SMUL_0742	COG1294	oxidase, subunit
SMUL_0743	COG0745	RESPONSE REGULATOR receiver
SMUL_0745	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SMUL_0747	COG0840	transmembrane signaling receptor activity
SMUL_0748	COG0318	PFAM AMP-dependent synthetase and ligase
SMUL_0749	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMUL_0750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMUL_0753	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMUL_0754	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMUL_0757	COG3706	GGDEF domain
SMUL_0759	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMUL_0766	COG5002	protein histidine kinase activity
SMUL_0766	COG2205	protein histidine kinase activity
SMUL_0766	COG0784	Response regulator, receiver
SMUL_0769	COG0322	excinuclease ABC activity
SMUL_0772	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SMUL_0774	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMUL_0774	COG0519	Catalyzes the synthesis of GMP from XMP
SMUL_0776	COG0151	Belongs to the GarS family
SMUL_0780	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMUL_0783	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUL_0783	COG2205	protein histidine kinase activity
SMUL_0789	COG0511	ligase activity, forming carbon-carbon bonds
SMUL_0791	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SMUL_0792	COG0165	Argininosuccinate lyase
SMUL_0793	COG0537	adenosine 5'-monophosphoramidase activity
SMUL_0794	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMUL_0795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUL_0795	COG0072	phenylalanine-tRNA ligase activity
SMUL_0796	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMUL_0797	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SMUL_0798	COG1185	polyribonucleotide nucleotidyltransferase activity
SMUL_0798	COG0539	negative regulation of cytoplasmic translation
SMUL_0800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMUL_0802	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMUL_0804	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMUL_0808	COG0840	transmembrane signaling receptor activity
SMUL_0810	COG0840	transmembrane signaling receptor activity
SMUL_0815	COG2081	HI0933 family
SMUL_0824	COG2199	diguanylate cyclase activity
SMUL_0824	COG2200	EAL domain
SMUL_0824	COG3287	FIST C domain
SMUL_0825	COG1902	pentaerythritol trinitrate reductase activity
SMUL_0826	COG1538	Outer membrane efflux protein
SMUL_0830	COG0840	transmembrane signaling receptor activity
SMUL_0831	COG0840	transmembrane signaling receptor activity
SMUL_0831	COG0840	transmembrane signaling receptor activity
SMUL_0833	COG0587	DNA-directed DNA polymerase activity
SMUL_0834	COG0517	IMP dehydrogenase activity
SMUL_0837	COG4191	Histidine kinase
SMUL_0839	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMUL_0840	COG0569	domain protein
SMUL_0843	COG0772	Belongs to the SEDS family
SMUL_0844	COG0564	pseudouridine synthase activity
SMUL_0846	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMUL_0850	COG0528	UMP kinase activity
SMUL_0851	COG1758	RNA polymerase activity
SMUL_0853	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SMUL_0855	COG0860	N-Acetylmuramoyl-L-alanine amidase
SMUL_0857	COG0563	adenylate kinase activity
SMUL_0858	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMUL_0859	COG3706	GGDEF domain
SMUL_0859	COG0745	RESPONSE REGULATOR receiver
SMUL_0861	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMUL_0862	COG0497	DNA recombination
SMUL_0863	COG1620	l-lactate permease
SMUL_0864	COG3706	GGDEF domain
SMUL_0865	COG0084	hydrolase, TatD family'
SMUL_0866	COG1388	LysM domain
SMUL_0866	COG3942	CHAP domain
SMUL_0867	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMUL_0868	COG0131	Imidazoleglycerol-phosphate dehydratase
SMUL_0869	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SMUL_0872	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SMUL_0875	COG0768	penicillin binding
SMUL_0877	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMUL_0879	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUL_0879	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUL_0881	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SMUL_0886	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMUL_0887	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMUL_0889	COG3005	denitrification pathway
SMUL_0891	COG1333	cytochrome c biogenesis protein
SMUL_0891	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMUL_0895	COG3545	Serine hydrolase
SMUL_0898	COG1346	cytolysis
SMUL_0901	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
SMUL_0903	COG0398	Pfam SNARE associated Golgi protein
SMUL_0905	COG0398	Pfam SNARE associated Golgi protein
SMUL_0906	COG2226	methyltransferase
SMUL_0913	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMUL_0914	COG4716	Myosin-crossreactive antigen
SMUL_0916	COG4585	Histidine kinase
SMUL_0919	COG0109	protoheme IX farnesyltransferase activity
SMUL_0920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMUL_0923	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMUL_0923	COG1845	cytochrome c oxidase, subunit III
SMUL_0931	COG4804	nuclease activity
SMUL_0934	COG0243	molybdopterin cofactor binding
SMUL_0935	COG0437	4 iron, 4 sulfur cluster binding
SMUL_0936	COG0348	domain, Protein
SMUL_0937	COG3043	anaerobic respiration
SMUL_0938	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMUL_0938	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMUL_0950	COG0243	molybdopterin cofactor binding
SMUL_0953	COG0745	RESPONSE REGULATOR receiver
SMUL_0955	COG3852	Histidine kinase
SMUL_0956	COG2863	cytochrome
SMUL_0957	COG0723	plastoquinol--plastocyanin reductase activity
SMUL_0958	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMUL_0962	COG3287	FIST C domain
SMUL_0962	COG2199	diguanylate cyclase activity
SMUL_0962	COG2200	EAL domain
SMUL_0963	COG0688	phosphatidylethanolamine metabolic process
SMUL_0964	COG0513	Belongs to the DEAD box helicase family
SMUL_0967	COG2964	Protein conserved in bacteria
SMUL_0968	COG2084	Dehydrogenase
SMUL_0971	COG0437	4 iron, 4 sulfur cluster binding
SMUL_0973	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMUL_0974	COG2258	MOSC domain
SMUL_0975	COG1280	lysine exporter protein (LysE YggA)
SMUL_0976	COG0784	Response regulator, receiver
SMUL_0976	COG3437	response regulator, receiver
SMUL_0979	COG0217	transcriptional regulatory protein
SMUL_0984	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMUL_0993	COG2801	Transposase and inactivated derivatives
SMUL_0994	COG2963	transposase activity
SMUL_0995	COG1696	Membrane protein involved in D-alanine export
SMUL_1005	COG1305	Transglutaminase-like
SMUL_1009	COG1305	Transglutaminase-like
SMUL_1011	COG2308	Evidence 4 Homologs of previously reported genes of
SMUL_1013	COG2966	Psort location CytoplasmicMembrane, score
SMUL_1014	COG3610	response to peptide
SMUL_1015	COG2703	oxygen carrier activity
SMUL_1016	COG2217	Heavy metal translocating P-type atpase
SMUL_1017	COG0640	Transcriptional regulator
SMUL_1018	COG1280	lysine exporter protein (LysE YggA)
SMUL_1020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMUL_1021	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMUL_1021	COG2169	Transcriptional regulator
SMUL_1023	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMUL_1025	COG3290	protein histidine kinase activity
SMUL_1025	COG0840	transmembrane signaling receptor activity
SMUL_1027	COG0352	thiamine-phosphate diphosphorylase activity
SMUL_1030	COG1272	protein, Hemolysin III
SMUL_1033	COG0247	lactate metabolic process
SMUL_1035	COG1556	Lactate utilization protein
SMUL_1036	COG0697	spore germination
SMUL_1040	COG2176	DNA-directed DNA polymerase activity
SMUL_1045	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SMUL_1047	COG0501	Belongs to the peptidase M48B family
SMUL_1051	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SMUL_1052	COG2201	protein-glutamate methylesterase activity
SMUL_1053	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMUL_1054	COG0586	Pfam SNARE associated Golgi protein
SMUL_1055	COG0133	tryptophan synthase activity
SMUL_1056	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMUL_1058	COG0698	ribose 5-phosphate isomerase
SMUL_1059	COG1994	Peptidase M50
SMUL_1060	COG0681	Belongs to the peptidase S26 family
SMUL_1061	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMUL_1083	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMUL_1086	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMUL_1087	COG0612	Peptidase, M16
SMUL_1088	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SMUL_1094	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
SMUL_1095	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMUL_1096	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SMUL_1097	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMUL_1098	COG0629	single-stranded DNA binding
SMUL_1099	COG0360	Binds together with S18 to 16S ribosomal RNA
SMUL_1100	COG1466	dna polymerase III delta subunit
SMUL_1101	COG0557	exoribonuclease II activity
SMUL_1103	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMUL_1104	COG2894	cell division
SMUL_1105	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SMUL_1107	COG0758	DNA mediated transformation
SMUL_1108	COG0730	response to heat
SMUL_1109	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMUL_1112	COG1760	l-serine dehydratase
SMUL_1113	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMUL_1114	COG2860	membrane
SMUL_1115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMUL_1118	COG0736	holo-[acyl-carrier-protein] synthase activity
SMUL_1119	COG1580	Controls the rotational direction of flagella during chemotaxis
SMUL_1120	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SMUL_1121	COG0552	protein localization to endoplasmic reticulum
SMUL_1122	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMUL_1124	COG1418	mRNA catabolic process
SMUL_1125	COG1132	(ABC) transporter
SMUL_1127	COG0586	Pfam SNARE associated Golgi protein
SMUL_1130	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SMUL_1133	COG0745	RESPONSE REGULATOR receiver
SMUL_1135	COG5002	protein histidine kinase activity
SMUL_1135	COG5001	Diguanylate cyclase
SMUL_1136	COG4191	Histidine kinase
SMUL_1136	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUL_1139	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMUL_1147	COG1518	maintenance of DNA repeat elements
SMUL_1172	COG3328	transposase activity
SMUL_1176	COG1450	Type ii and iii secretion system protein
SMUL_1183	COG5002	protein histidine kinase activity
SMUL_1184	COG1408	metallophosphoesterase
SMUL_1185	COG2353	YceI-like domain
SMUL_1188	COG1136	(ABC) transporter
SMUL_1191	COG4456	Virulence-associated protein
SMUL_1196	COG3328	transposase activity
SMUL_1202	COG0242	peptide deformylase activity
SMUL_1203	COG0824	Thioesterase
SMUL_1205	COG1573	uracil-dna glycosylase
SMUL_1208	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMUL_1212	COG3287	FIST C domain
SMUL_1212	COG2199	diguanylate cyclase activity
SMUL_1212	COG2200	EAL domain
SMUL_1214	COG0745	RESPONSE REGULATOR receiver
SMUL_1215	COG0426	domain, Protein
SMUL_1220	COG2040	homocysteine
SMUL_1221	COG1012	belongs to the aldehyde dehydrogenase family
SMUL_1222	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SMUL_1222	COG3264	Mechanosensitive ion channel
SMUL_1224	COG2205	protein histidine kinase activity
SMUL_1224	COG0784	Response regulator, receiver
SMUL_1225	COG0784	Response regulator, receiver
SMUL_1225	COG3437	response regulator, receiver
SMUL_1227	COG3437	response regulator, receiver
SMUL_1229	COG1433	Dinitrogenase iron-molybdenum cofactor
SMUL_1236	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SMUL_1243	COG2026	Addiction module toxin, RelE StbE family
SMUL_1244	COG3645	SOS response
SMUL_1255	COG1451	nucleotide metabolic process
SMUL_1265	COG0697	spore germination
SMUL_1267	COG3706	GGDEF domain
SMUL_1268	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMUL_1275	COG0840	transmembrane signaling receptor activity
SMUL_1276	COG0840	transmembrane signaling receptor activity
SMUL_1277	COG0243	molybdopterin cofactor binding
SMUL_1280	COG0747	negative chemotaxis
SMUL_1284	COG1276	copper resistance
SMUL_1285	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SMUL_1291	COG0745	RESPONSE REGULATOR receiver
SMUL_1293	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMUL_1293	COG3153	acetyltransferase
SMUL_1301	COG5002	protein histidine kinase activity
SMUL_1304	COG0493	'glutamate synthase
SMUL_1305	COG0375	protein maturation
SMUL_1306	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMUL_1308	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_1310	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_1313	COG2814	Major facilitator Superfamily
SMUL_1319	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMUL_1321	COG1131	(ABC) transporter
SMUL_1322	COG0842	Transport permease protein
SMUL_1323	COG4456	Virulence-associated protein
SMUL_1329	COG0667	Aldo Keto reductase
SMUL_1330	COG1053	succinate dehydrogenase
SMUL_1337	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SMUL_1338	COG0585	pseudouridine synthase activity
SMUL_1339	COG0569	domain protein
SMUL_1339	COG0475	glutathione-regulated potassium exporter activity
SMUL_1343	COG2203	Gaf domain
SMUL_1343	COG2199	diguanylate cyclase activity
SMUL_1344	COG0352	thiamine-phosphate diphosphorylase activity
SMUL_1344	COG0351	phosphomethylpyrimidine kinase
SMUL_1346	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SMUL_1348	COG0428	transporter
SMUL_1350	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMUL_1352	COG0840	transmembrane signaling receptor activity
SMUL_1353	COG1234	tRNA 3'-trailer cleavage
SMUL_1355	COG0488	(ABC) transporter
SMUL_1356	COG1360	Flagellar Motor Protein
SMUL_1357	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SMUL_1358	COG1309	transcriptional regulator
SMUL_1361	COG1538	Outer membrane efflux protein
SMUL_1364	COG0778	Nitroreductase
SMUL_1365	COG0778	Nitroreductase
SMUL_1366	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMUL_1370	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SMUL_1375	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SMUL_1379	COG4145	pantothenate transmembrane transporter activity
SMUL_1382	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SMUL_1385	COG0742	ribosomal rna small subunit methyltransferase
SMUL_1386	COG1706	bacterial-type flagellum-dependent cell motility
SMUL_1387	COG3951	Flagellar rod assembly protein muramidase FlgJ
SMUL_1391	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMUL_1393	COG0659	secondary active sulfate transmembrane transporter activity
SMUL_1394	COG1942	4-Oxalocrotonate Tautomerase
SMUL_1395	COG0356	it plays a direct role in the translocation of protons across the membrane
SMUL_1399	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMUL_1402	COG0101	tRNA pseudouridine synthase activity
SMUL_1404	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SMUL_1406	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SMUL_1407	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMUL_1408	COG1338	Plays a role in the flagellum-specific transport system
SMUL_1409	COG0676	glucose-6-phosphate 1-epimerase activity
SMUL_1410	COG1733	regulation of RNA biosynthetic process
SMUL_1411	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMUL_1413	COG4269	membrane
SMUL_1416	COG3174	membrane
SMUL_1417	COG1032	radical SAM domain protein
SMUL_1418	COG0166	Belongs to the GPI family
SMUL_1423	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
SMUL_1424	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SMUL_1425	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
SMUL_1426	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SMUL_1427	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SMUL_1428	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SMUL_1430	COG4774	siderophore transport
SMUL_1434	COG0298	carbon dioxide binding
SMUL_1435	COG0409	Hydrogenase expression formation protein
SMUL_1436	COG0309	Hydrogenase expression formation protein (HypE)
SMUL_1438	COG1247	-acetyltransferase
SMUL_1439	COG0546	phosphoglycolate phosphatase activity
SMUL_1443	COG0039	L-malate dehydrogenase activity
SMUL_1444	COG0745	RESPONSE REGULATOR receiver
SMUL_1445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUL_1445	COG2205	protein histidine kinase activity
SMUL_1447	COG0471	metal ion transport
SMUL_1448	COG0247	lactate metabolic process
SMUL_1449	COG0277	FAD linked oxidase domain protein
SMUL_1450	COG0045	succinate-CoA ligase (ADP-forming) activity
SMUL_1451	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SMUL_1453	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SMUL_1453	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMUL_1454	COG3962	Belongs to the TPP enzyme family
SMUL_1459	COG0114	fumarate hydratase activity
SMUL_1462	COG2095	MarC family integral membrane protein
SMUL_1466	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMUL_1467	COG0750	zinc metalloprotease
SMUL_1468	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMUL_1469	COG1028	Short-chain dehydrogenase reductase Sdr
SMUL_1470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMUL_1472	COG0167	dihydroorotate dehydrogenase activity
SMUL_1473	COG1132	(ABC) transporter
SMUL_1474	COG0215	cysteine-tRNA ligase activity
SMUL_1475	COG0728	peptidoglycan biosynthetic process
SMUL_1477	COG0632	four-way junction helicase activity
SMUL_1478	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMUL_1482	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMUL_1483	COG0857	belongs to the CobB CobQ family
SMUL_1483	COG0280	phosphate acetyltransferase
SMUL_1484	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SMUL_1497	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SMUL_1498	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SMUL_1501	COG0137	argininosuccinate synthase activity
SMUL_1502	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SMUL_1503	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMUL_1504	COG0802	atpase or kinase
SMUL_1505	COG1137	ATPase activity
SMUL_1506	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SMUL_1511	COG0419	ATPase involved in DNA repair
SMUL_1512	COG1196	nuclear chromosome segregation
SMUL_1526	COG1053	succinate dehydrogenase
SMUL_1534	COG3852	Histidine kinase
SMUL_1538	COG4191	Histidine kinase
SMUL_1538	COG0784	Response regulator, receiver
SMUL_1539	COG0745	RESPONSE REGULATOR receiver
SMUL_1541	COG0437	4 iron, 4 sulfur cluster binding
SMUL_1543	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SMUL_1545	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
SMUL_1549	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SMUL_1553	COG1120	ATPase activity
SMUL_1556	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SMUL_1560	COG2875	Belongs to the precorrin methyltransferase family
SMUL_1565	COG1132	(ABC) transporter
SMUL_1566	COG1797	cobyrinic acid a,c-diamide synthase activity
SMUL_1568	COG1648	precorrin-2 dehydrogenase activity
SMUL_1568	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SMUL_1595	COG0582	viral genome integration into host DNA
SMUL_1597	COG0776	regulation of translation
SMUL_1598	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMUL_1599	COG1196	nuclear chromosome segregation
SMUL_1599	COG1674	ftsk spoiiie
SMUL_1600	COG1049	propionate catabolic process, 2-methylcitrate cycle
SMUL_1601	COG1047	Peptidyl-prolyl cis-trans
SMUL_1602	COG0574	Belongs to the PEP-utilizing enzyme family
SMUL_1602	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMUL_1603	COG2814	Major facilitator Superfamily
SMUL_1607	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMUL_1609	COG1832	CoA-binding protein
SMUL_1610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMUL_1612	COG1126	abc transporter atp-binding protein
SMUL_1613	COG0765	amino acid transport
SMUL_1614	COG4597	amino acid ABC transporter
SMUL_1615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUL_1616	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SMUL_1619	COG0586	Pfam SNARE associated Golgi protein
SMUL_1622	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMUL_1625	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SMUL_1626	COG0727	PFAM Uncharacterised protein family (UPF0153)
SMUL_1628	COG0134	indole-3-glycerol-phosphate synthase activity
SMUL_1630	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SMUL_1632	COG0310	cobalt ion transport
SMUL_1636	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SMUL_1637	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SMUL_1640	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMUL_1642	COG0248	Ppx GppA phosphatase
SMUL_1643	COG0028	Belongs to the TPP enzyme family
SMUL_1645	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMUL_1647	COG0493	'glutamate synthase
SMUL_1649	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SMUL_1655	COG1045	serine acetyltransferase
SMUL_1656	COG1166	arginine decarboxylase activity
SMUL_1657	COG0124	histidyl-tRNA synthetase
SMUL_1659	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMUL_1660	COG0163	prenyltransferase activity
SMUL_1663	COG0840	transmembrane signaling receptor activity
SMUL_1664	COG0303	'Molybdopterin
SMUL_1665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMUL_1672	COG0489	protein tyrosine kinase activity
SMUL_1674	COG1342	Belongs to the UPF0251 family
SMUL_1675	COG1691	(AIR) carboxylase
SMUL_1676	COG1606	tRNA processing
SMUL_1677	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SMUL_1678	COG3875	lactate racemase activity
SMUL_1679	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SMUL_1679	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SMUL_1681	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SMUL_1688	COG0582	viral genome integration into host DNA
SMUL_1689	COG0343	queuine tRNA-ribosyltransferase activity
SMUL_1691	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SMUL_1693	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMUL_1694	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMUL_1698	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMUL_1701	COG2378	regulation of single-species biofilm formation
SMUL_1702	COG1187	pseudouridine synthase activity
SMUL_1703	COG0028	Belongs to the TPP enzyme family
SMUL_1705	COG2066	Belongs to the glutaminase family
SMUL_1709	COG1309	transcriptional regulator
SMUL_1715	COG0840	transmembrane signaling receptor activity
SMUL_1736	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMUL_1740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMUL_1762	COG3328	transposase activity
SMUL_1773	COG0582	viral genome integration into host DNA
SMUL_1778	COG0776	regulation of translation
SMUL_1819	COG3344	reverse transcriptase
SMUL_1832	COG0629	single-stranded DNA binding
SMUL_1875	COG4774	siderophore transport
SMUL_1897	COG0582	viral genome integration into host DNA
SMUL_1899	COG1592	Rubrerythrin
SMUL_1901	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SMUL_1902	COG0181	hydroxymethylbilane synthase activity
SMUL_1905	COG0442	prolyl-tRNA aminoacylation
SMUL_1906	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SMUL_1907	COG0142	geranyltranstransferase activity
SMUL_1911	COG1959	2 iron, 2 sulfur cluster binding
SMUL_1913	COG3706	GGDEF domain
SMUL_1914	COG0525	valine-tRNA ligase activity
SMUL_1915	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SMUL_1916	COG0521	Mo-molybdopterin cofactor biosynthetic process
SMUL_1918	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMUL_1921	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMUL_1922	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SMUL_1924	COG2195	Cleaves the N-terminal amino acid of tripeptides
SMUL_1926	COG0500	methyltransferase
SMUL_1929	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMUL_1930	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMUL_1931	COG1663	tetraacyldisaccharide 4'-kinase activity
SMUL_1932	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMUL_1933	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SMUL_1934	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SMUL_1937	COG4232	protein-disulfide reductase activity
SMUL_1939	COG0443	Heat shock 70 kDa protein
SMUL_1940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMUL_1941	COG1420	regulation of RNA biosynthetic process
SMUL_1944	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMUL_1946	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMUL_1947	COG2404	hydrolase activity, acting on ester bonds
SMUL_1949	COG2226	methyltransferase
SMUL_1950	COG3706	GGDEF domain
SMUL_1951	COG0196	riboflavin kinase activity
SMUL_1952	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMUL_1953	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMUL_1954	COG0730	response to heat
SMUL_1956	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SMUL_1959	COG0527	aspartate kinase activity
SMUL_1960	COG0494	nUDIX hydrolase
SMUL_1961	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMUL_1963	COG0789	Transcriptional regulator
SMUL_1964	COG0484	heat shock protein binding
SMUL_1965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMUL_1966	COG0745	RESPONSE REGULATOR receiver
SMUL_1967	COG5002	protein histidine kinase activity
SMUL_1970	COG0653	protein targeting
SMUL_1973	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SMUL_1974	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SMUL_1976	COG0706	membrane insertase activity
SMUL_1977	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SMUL_1980	COG4865	methylaspartate mutase activity
SMUL_2004	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SMUL_2007	COG0542	response to heat
SMUL_2008	COG0793	Belongs to the peptidase S41A family
SMUL_2010	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMUL_2011	COG0047	phosphoribosylformylglycinamidine synthase activity
SMUL_2013	COG0204	Acyl-transferase
SMUL_2014	COG0326	Molecular chaperone. Has ATPase activity
SMUL_2015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMUL_2019	COG1331	Highly conserved protein containing a thioredoxin domain
SMUL_2020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMUL_2028	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMUL_2033	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SMUL_2035	COG2608	mercury ion transmembrane transporter activity
SMUL_2036	COG2217	Heavy metal translocating P-type atpase
SMUL_2037	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMUL_2040	COG0275	rRNA processing
SMUL_2042	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMUL_2043	COG0849	cell division
SMUL_2044	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SMUL_2046	COG2890	protein-(glutamine-N5) methyltransferase activity
SMUL_2047	COG0501	Belongs to the peptidase M48B family
SMUL_2050	COG0840	transmembrane signaling receptor activity
SMUL_2052	COG2151	metal-sulfur cluster biosynthetic enzyme
SMUL_2055	COG0138	bifunctional purine biosynthesis protein purh
SMUL_2056	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SMUL_2058	COG1607	acyl-coa hydrolase
SMUL_2059	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SMUL_2060	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SMUL_2064	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMUL_2066	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMUL_2067	COG0805	protein transport
SMUL_2068	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SMUL_2072	COG3328	transposase activity
SMUL_2074	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SMUL_2076	COG0765	amino acid transport
SMUL_2079	COG3437	response regulator, receiver
SMUL_2081	COG3437	response regulator, receiver
SMUL_2081	COG2205	protein histidine kinase activity
SMUL_2081	COG4999	Histidine kinase
SMUL_2081	COG3850	Histidine kinase
SMUL_2082	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMUL_2083	COG1022	Amp-dependent synthetase and ligase
SMUL_2085	COG4206	TonB-dependent receptor
SMUL_2086	COG2205	protein histidine kinase activity
SMUL_2087	COG0745	RESPONSE REGULATOR receiver
SMUL_2088	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMUL_2089	COG0569	domain protein
SMUL_2090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMUL_2093	COG2068	MobA-Related Protein
SMUL_2094	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SMUL_2094	COG3608	succinylglutamate desuccinylase aspartoacylase
SMUL_2095	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SMUL_2096	COG0535	radical SAM domain protein
SMUL_2102	COG0642	Histidine kinase
SMUL_2105	COG3038	cytochrome b561
SMUL_2108	COG0745	RESPONSE REGULATOR receiver
SMUL_2110	COG1230	cation diffusion facilitator family transporter
SMUL_2114	COG4774	siderophore transport
SMUL_2116	COG0668	transmembrane transport
SMUL_2123	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SMUL_2124	COG4263	nitrous-oxide reductase activity
SMUL_2127	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SMUL_2129	COG0646	methionine synthase
SMUL_2129	COG1410	methionine synthase
SMUL_2132	COG0840	transmembrane signaling receptor activity
SMUL_2133	COG1280	lysine exporter protein (LysE YggA)
SMUL_2136	COG0004	ammonium transporteR
SMUL_2137	COG0347	Belongs to the P(II) protein family
SMUL_2139	COG1401	restriction endodeoxyribonuclease activity
SMUL_2146	COG0288	reversible hydration of carbon dioxide
SMUL_2147	COG3123	guanosine phosphorylase activity
SMUL_2149	COG2081	HI0933 family
SMUL_2151	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SMUL_2152	COG0788	formyltetrahydrofolate deformylase activity
SMUL_2153	COG0617	tRNA 3'-terminal CCA addition
SMUL_2156	COG0473	3-isopropylmalate dehydrogenase activity
SMUL_2157	COG0066	3-isopropylmalate dehydratase activity
SMUL_2158	COG1119	ATPase activity
SMUL_2162	COG0708	Exodeoxyribonuclease III
SMUL_2165	COG0840	transmembrane signaling receptor activity
SMUL_2167	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMUL_2168	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
SMUL_2169	COG3005	denitrification pathway
SMUL_2170	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
SMUL_2171	COG0840	transmembrane signaling receptor activity
SMUL_2173	COG0745	RESPONSE REGULATOR receiver
SMUL_2177	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SMUL_2179	COG3706	GGDEF domain
SMUL_2181	COG4895	conserved protein (DUF2196)
SMUL_2185	COG0513	Belongs to the DEAD box helicase family
SMUL_2187	COG5001	Diguanylate cyclase
SMUL_2188	COG0642	Histidine kinase
SMUL_2189	COG0745	RESPONSE REGULATOR receiver
SMUL_2196	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SMUL_2197	COG0372	Belongs to the citrate synthase family
SMUL_2198	COG2079	MmgE PrpD family protein
SMUL_2200	COG2824	Alkylphosphonate utilization operon protein PhnA
SMUL_2202	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SMUL_2204	COG4786	Flagellar basal body rod
SMUL_2205	COG4786	Flagellar basal body rod
SMUL_2206	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMUL_2208	COG1733	regulation of RNA biosynthetic process
SMUL_2211	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMUL_2212	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMUL_2213	COG3162	membrane
SMUL_2214	COG0745	RESPONSE REGULATOR receiver
SMUL_2216	COG2957	Belongs to the agmatine deiminase family
SMUL_2218	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SMUL_2219	COG1918	ferrous iron import across plasma membrane
SMUL_2224	COG3585	molybdate ion transport
SMUL_2226	COG0598	Magnesium transport protein CorA
SMUL_2227	COG0739	heme binding
SMUL_2229	COG0277	FAD linked oxidase domain protein
SMUL_2230	COG1295	ribonuclease BN
SMUL_2232	COG0305	Participates in initiation and elongation during chromosome replication
SMUL_2232	COG0305	Participates in initiation and elongation during chromosome replication
SMUL_2233	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMUL_2234	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SMUL_2235	COG4969	Belongs to the N-Me-Phe pilin family
SMUL_2239	COG0556	nucleotide-excision repair
SMUL_2242	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SMUL_2243	COG2176	DNA-directed DNA polymerase activity
SMUL_2244	COG0135	phosphoribosylanthranilate isomerase activity
SMUL_2245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SMUL_2247	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMUL_2250	COG1692	metallophosphoesterase
SMUL_2251	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SMUL_2253	COG0739	heme binding
SMUL_2254	COG0285	dihydrofolate synthase activity
SMUL_2255	COG3706	GGDEF domain
SMUL_2257	COG0495	leucyl-tRNA aminoacylation
SMUL_2258	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMUL_2259	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMUL_2260	COG1862	Preprotein translocase
SMUL_2261	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SMUL_2262	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMUL_2264	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SMUL_2265	COG0542	response to heat
SMUL_2266	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SMUL_2268	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMUL_2269	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMUL_2270	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SMUL_2271	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SMUL_2272	COG0210	DNA helicase
SMUL_2278	COG0540	Belongs to the ATCase OTCase family
SMUL_2280	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SMUL_2287	COG0336	Belongs to the RNA methyltransferase TrmD family
SMUL_2289	COG1837	Belongs to the UPF0109 family
SMUL_2290	COG0228	four-way junction DNA binding
SMUL_2291	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SMUL_2292	COG0564	pseudouridine synthase activity
SMUL_2293	COG1519	Transferase
SMUL_2295	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SMUL_2296	COG0752	glycyl-tRNA synthetase alpha subunit
SMUL_2298	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SMUL_2301	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SMUL_2302	COG0174	glutamine synthetase
SMUL_2304	COG0444	Belongs to the ABC transporter superfamily
SMUL_2305	COG0156	8-amino-7-oxononanoate synthase activity
SMUL_2306	COG0424	maF-like protein
SMUL_2308	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMUL_2310	COG0745	RESPONSE REGULATOR receiver
SMUL_2311	COG5002	protein histidine kinase activity
SMUL_2312	COG0243	molybdopterin cofactor binding
SMUL_2313	COG0437	4 iron, 4 sulfur cluster binding
SMUL_2314	COG3302	dmso reductase anchor subunit
SMUL_2315	COG3381	protein complex oligomerization
SMUL_2319	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SMUL_2322	COG1558	bacterial-type flagellum-dependent cell motility
SMUL_2323	COG1815	bacterial-type flagellum-dependent cell motility
SMUL_2324	COG0772	Belongs to the SEDS family
SMUL_2325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMUL_2328	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SMUL_2330	COG0697	spore germination
SMUL_2339	COG2814	Major facilitator Superfamily
SMUL_2340	COG0204	Acyl-transferase
SMUL_2340	COG0318	PFAM AMP-dependent synthetase and ligase
SMUL_2341	COG0640	Transcriptional regulator
SMUL_2345	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
SMUL_2347	COG2301	Belongs to the HpcH HpaI aldolase family
SMUL_2349	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SMUL_2350	COG3180	Ammonia monooxygenase
SMUL_2352	COG3290	protein histidine kinase activity
SMUL_2353	COG4565	transcriptional regulatory protein
SMUL_2357	COG0784	Response regulator, receiver
SMUL_2357	COG2205	protein histidine kinase activity
SMUL_2357	COG5002	protein histidine kinase activity
SMUL_2358	COG3437	response regulator, receiver
SMUL_2359	COG2814	Major facilitator Superfamily
SMUL_2361	COG2252	PERMEase
SMUL_2362	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMUL_2365	COG0133	tryptophan synthase activity
SMUL_2368	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMUL_2369	COG3706	GGDEF domain
SMUL_2375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMUL_2380	COG0488	(ABC) transporter
SMUL_2383	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMUL_2384	COG0651	ATP synthesis coupled electron transport
SMUL_2385	COG0650	Formate hydrogenlyase subunit 4
SMUL_2386	COG4237	Hydrogenase 4 membrane
SMUL_2387	COG0651	ATP synthesis coupled electron transport
SMUL_2388	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
SMUL_2388	COG3261	NADH dehydrogenase
SMUL_2390	COG3260	NADH ubiquinone oxidoreductase 20
SMUL_2395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMUL_2397	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SMUL_2398	COG0745	RESPONSE REGULATOR receiver
SMUL_2398	COG3706	GGDEF domain
SMUL_2401	COG2171	N-acyltransferase activity
SMUL_2402	COG0489	protein tyrosine kinase activity
SMUL_2403	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SMUL_2403	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SMUL_2405	COG2046	Belongs to the sulfate adenylyltransferase family
SMUL_2408	COG2353	YceI-like domain
SMUL_2409	COG1739	Uncharacterized protein family UPF0029
SMUL_2410	COG0157	Belongs to the NadC ModD family
SMUL_2411	COG4208	sulfate ABC transporter
SMUL_2413	COG3842	ATPase activity
SMUL_2418	COG1686	Belongs to the peptidase S11 family
SMUL_2419	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SMUL_2420	COG1136	(ABC) transporter
SMUL_2420	COG0577	efflux transmembrane transporter activity
SMUL_2421	COG1136	(ABC) transporter
SMUL_2421	COG0577	efflux transmembrane transporter activity
SMUL_2422	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMUL_2426	COG0668	transmembrane transport
SMUL_2442	COG0284	orotidine-5'-phosphate decarboxylase activity
SMUL_2443	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMUL_2444	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SMUL_2447	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SMUL_2448	COG0697	spore germination
SMUL_2449	COG0668	transmembrane transport
SMUL_2450	COG1160	GTP binding
SMUL_2452	COG0180	Tryptophanyl-tRNA synthetase
SMUL_2453	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMUL_2455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMUL_2456	COG1183	phosphatidylcholine synthase activity
SMUL_2458	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMUL_2459	COG2264	protein methyltransferase activity
SMUL_2461	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMUL_2462	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMUL_2465	COG1086	Polysaccharide biosynthesis protein
SMUL_2466	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMUL_2469	COG0438	transferase activity, transferring glycosyl groups
SMUL_2470	COG0110	maltose O-acetyltransferase activity
SMUL_2473	COG0110	maltose O-acetyltransferase activity
SMUL_2477	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMUL_2479	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMUL_2480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMUL_2482	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SMUL_2485	COG1793	dna ligase
SMUL_2487	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SMUL_2488	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMUL_2497	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SMUL_2498	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SMUL_2498	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SMUL_2499	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SMUL_2503	COG2217	Heavy metal translocating P-type atpase
SMUL_2503	COG2608	mercury ion transmembrane transporter activity
SMUL_2504	COG5002	protein histidine kinase activity
SMUL_2504	COG5001	Diguanylate cyclase
SMUL_2505	COG0697	spore germination
SMUL_2507	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SMUL_2511	COG0840	transmembrane signaling receptor activity
SMUL_2512	COG1984	allophanate hydrolase subunit 2
SMUL_2514	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SMUL_2518	COG0745	RESPONSE REGULATOR receiver
SMUL_2519	COG0840	transmembrane signaling receptor activity
SMUL_2520	COG0445	tRNA wobble uridine modification
SMUL_2521	COG0723	plastoquinol--plastocyanin reductase activity
SMUL_2525	COG0825	malonyl-CoA metabolic process
SMUL_2526	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMUL_2527	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMUL_2529	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SMUL_2530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMUL_2531	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SMUL_2533	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SMUL_2537	COG0300	oxidoreductase activity
SMUL_2538	COG0277	FAD linked oxidase domain protein
SMUL_2540	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SMUL_2541	COG2801	Transposase and inactivated derivatives
SMUL_2558	COG1134	teichoic acid transport
SMUL_2562	COG1682	transport, permease protein
SMUL_2563	COG1088	dTDP-glucose 4,6-dehydratase activity
SMUL_2566	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SMUL_2567	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMUL_2571	COG4191	Histidine kinase
SMUL_2572	COG0745	RESPONSE REGULATOR receiver
SMUL_2573	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SMUL_2576	COG0390	transport system, permease component
SMUL_2577	COG0439	Biotin carboxylase
SMUL_2580	COG0306	phosphate transporter
SMUL_2581	COG0513	Belongs to the DEAD box helicase family
SMUL_2582	COG1671	Belongs to the UPF0178 family
SMUL_2584	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMUL_2586	COG0573	inorganic phosphate transmembrane transporter activity
SMUL_2587	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SMUL_2588	COG0840	transmembrane signaling receptor activity
SMUL_2588	COG3290	protein histidine kinase activity
SMUL_2589	COG3384	dioxygenase
SMUL_2590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMUL_2591	COG0471	metal ion transport
SMUL_2592	COG0840	transmembrane signaling receptor activity
SMUL_2597	COG0745	RESPONSE REGULATOR receiver
SMUL_2599	COG1607	acyl-coa hydrolase
SMUL_2605	COG1733	regulation of RNA biosynthetic process
SMUL_2606	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMUL_2608	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SMUL_2609	COG0602	queuosine metabolic process
SMUL_2614	COG1702	phosphate starvation-inducible protein PhoH
SMUL_2616	COG2814	Major facilitator Superfamily
SMUL_2617	COG0477	Major facilitator Superfamily
SMUL_2619	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMUL_2623	COG3787	Belongs to the UPF0306 family
SMUL_2624	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SMUL_2630	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMUL_2630	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SMUL_2630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMUL_2630	COG1013	pyruvate-flavodoxin oxidoreductase activity
SMUL_2631	COG0546	phosphoglycolate phosphatase activity
SMUL_2636	COG2818	Glycosylase
SMUL_2638	COG1979	alcohol dehydrogenase
SMUL_2640	COG0038	chloride channel
SMUL_2641	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SMUL_2644	COG4680	protein conserved in bacteria
SMUL_2646	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMUL_2655	COG3278	Belongs to the heme-copper respiratory oxidase family
SMUL_2656	COG0745	RESPONSE REGULATOR receiver
SMUL_2659	COG0505	Belongs to the CarA family
SMUL_2663	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMUL_2664	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SMUL_2665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SMUL_2667	COG0840	transmembrane signaling receptor activity
SMUL_2668	COG0546	phosphoglycolate phosphatase activity
SMUL_2669	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMUL_2672	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMUL_2673	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SMUL_2674	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMUL_2677	COG0203	ribosomal protein L17
SMUL_2679	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMUL_2680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMUL_2681	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMUL_2682	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SMUL_2684	COG0024	Methionine aminopeptidase
SMUL_2685	COG0201	protein transport
SMUL_2686	COG0200	Binds to the 23S rRNA
SMUL_2689	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMUL_2690	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMUL_2693	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMUL_2694	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMUL_2695	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMUL_2696	COG0255	Belongs to the universal ribosomal protein uL29 family
SMUL_2697	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMUL_2698	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMUL_2700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMUL_2701	COG0089	rRNA binding
SMUL_2702	COG0088	Forms part of the polypeptide exit tunnel
SMUL_2703	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMUL_2704	COG0051	transcription antitermination factor activity, RNA binding
SMUL_2707	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMUL_2708	COG0672	)-iron permease
SMUL_2713	COG1136	(ABC) transporter
SMUL_2713	COG0577	efflux transmembrane transporter activity
SMUL_2718	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SMUL_2719	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMUL_2720	COG0571	ribonuclease III activity
SMUL_2721	COG0328	RNA-DNA hybrid ribonuclease activity
SMUL_2723	COG0358	DNA primase activity
SMUL_2724	COG0137	argininosuccinate synthase activity
SMUL_2725	COG2201	protein-glutamate methylesterase activity
SMUL_2729	COG0840	transmembrane signaling receptor activity
SMUL_2730	COG2201	protein-glutamate methylesterase activity
SMUL_2731	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SMUL_2732	COG2205	protein histidine kinase activity
SMUL_2733	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SMUL_2736	COG0840	transmembrane signaling receptor activity
SMUL_2737	COG0835	chemotaxis
SMUL_2739	COG0484	heat shock protein binding
SMUL_2761	COG4206	TonB-dependent receptor
SMUL_2765	COG1918	ferrous iron import across plasma membrane
SMUL_2765	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SMUL_2766	COG1918	ferrous iron import across plasma membrane
SMUL_2768	COG4773	Receptor
SMUL_2773	COG0848	biopolymer transport protein
SMUL_2774	COG0811	peptide transport
SMUL_2778	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SMUL_2781	COG1011	Hydrolase
SMUL_2782	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
SMUL_2783	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
SMUL_2787	COG1280	lysine exporter protein (LysE YggA)
SMUL_2788	COG1090	epimerase
SMUL_2797	COG2962	Rard protein
SMUL_2799	COG0642	Histidine kinase
SMUL_2800	COG2194	sulfuric ester hydrolase activity
SMUL_2802	COG2200	EAL domain
SMUL_2803	COG4191	Histidine kinase
SMUL_2804	COG4191	Histidine kinase
SMUL_2806	COG0840	transmembrane signaling receptor activity
SMUL_2809	COG1342	Belongs to the UPF0251 family
SMUL_2810	COG1968	undecaprenyl-diphosphatase activity
SMUL_2811	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SMUL_2816	COG1027	Aspartate ammonia-lyase
SMUL_2817	COG1027	Aspartate ammonia-lyase
SMUL_2818	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SMUL_2819	COG0252	asparaginase activity
SMUL_2820	COG3852	Histidine kinase
SMUL_2821	COG0745	RESPONSE REGULATOR receiver
SMUL_2825	COG3177	Filamentation induced by cAMP protein fic
SMUL_2827	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SMUL_2837	COG1333	cytochrome c biogenesis protein
SMUL_2837	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMUL_2838	COG3301	Polysulphide reductase, NrfD
SMUL_2839	COG0437	4 iron, 4 sulfur cluster binding
SMUL_2840	COG0545	Peptidyl-prolyl cis-trans isomerase
SMUL_2841	COG0484	heat shock protein binding
SMUL_2842	COG3852	Histidine kinase
SMUL_2844	COG0840	transmembrane signaling receptor activity
SMUL_2849	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMUL_2850	COG0586	Pfam SNARE associated Golgi protein
SMUL_2854	COG0848	biopolymer transport protein
SMUL_2855	COG0811	peptide transport
SMUL_2856	COG0709	Synthesizes selenophosphate from selenide and ATP
SMUL_2857	COG0425	Belongs to the sulfur carrier protein TusA family
SMUL_2860	COG3447	MASE1 domain protein
SMUL_2860	COG5001	Diguanylate cyclase
SMUL_2860	COG5002	protein histidine kinase activity
SMUL_2864	COG4662	Binding-protein-dependent transport system inner membrane component
SMUL_2865	COG2998	abc-type tungstate transport system, permease component
SMUL_2866	COG1177	transmembrane transport
SMUL_2867	COG3842	ATPase activity
SMUL_2868	COG0725	ABC transporter, periplasmic molybdate-binding protein
SMUL_2870	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SMUL_2872	COG0437	4 iron, 4 sulfur cluster binding
SMUL_2884	COG0848	biopolymer transport protein
SMUL_2885	COG0811	peptide transport
SMUL_2891	COG0500	methyltransferase
SMUL_2893	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMUL_2898	COG4977	sequence-specific DNA binding
SMUL_2898	COG1917	Cupin 2, conserved barrel domain protein
SMUL_2900	COG0437	4 iron, 4 sulfur cluster binding
SMUL_2906	COG4191	Histidine kinase
SMUL_2907	COG0745	RESPONSE REGULATOR receiver
SMUL_2908	COG1921	L-seryl-tRNASec selenium transferase activity
SMUL_2913	COG1741	Belongs to the pirin family
SMUL_2920	COG0745	RESPONSE REGULATOR receiver
SMUL_2921	COG5000	phosphorelay sensor kinase activity
SMUL_2921	COG5002	protein histidine kinase activity
SMUL_2928	COG2986	histidine ammonia-lyase
SMUL_2929	COG1028	Short-chain dehydrogenase reductase Sdr
SMUL_2933	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMUL_2936	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMUL_2937	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMUL_2938	COG0513	Belongs to the DEAD box helicase family
SMUL_2944	COG1305	Transglutaminase-like
SMUL_2950	COG0439	Biotin carboxylase
SMUL_2952	COG3665	Urea carboxylase-associated protein
SMUL_2953	COG3842	ATPase activity
SMUL_2954	COG2011	ABC-type metal ion transport system permease component
SMUL_2956	COG2205	protein histidine kinase activity
SMUL_2956	COG2202	Pas domain
SMUL_2959	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMUL_2960	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SMUL_2962	COG1840	ABC-type Fe3 transport system, periplasmic component
SMUL_2963	COG3842	ATPase activity
SMUL_2965	COG0745	RESPONSE REGULATOR receiver
SMUL_2966	COG2205	protein histidine kinase activity
SMUL_2967	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SMUL_2968	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SMUL_2969	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SMUL_2970	COG0523	cobalamin synthesis protein
SMUL_2973	COG4191	Histidine kinase
SMUL_2975	COG0700	Nucleoside recognition
SMUL_2976	COG3366	ferrous iron transmembrane transporter activity
SMUL_2977	COG1473	amidohydrolase
SMUL_2980	COG0300	oxidoreductase activity
SMUL_2983	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SMUL_2984	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SMUL_2986	COG2814	Major facilitator Superfamily
SMUL_2987	COG1238	metal cluster binding
SMUL_2991	COG0303	'Molybdopterin
SMUL_2992	COG0314	molybdopterin synthase activity
SMUL_2995	COG1104	cysteine desulfurase activity
SMUL_2996	COG1157	protein secretion by the type III secretion system
SMUL_2997	COG0302	gtp cyclohydrolase
SMUL_2998	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMUL_2999	COG0740	serine-type endopeptidase activity
SMUL_3003	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SMUL_3003	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SMUL_3004	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SMUL_3005	COG2022	thiamine diphosphate biosynthetic process
SMUL_3017	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SMUL_3018	COG1053	succinate dehydrogenase
SMUL_3018	COG0431	NADPH-dependent FMN reductase
SMUL_3018	COG3976	FMN-binding domain protein
SMUL_3019	COG0644	oxidoreductase
SMUL_3030	COG0437	4 iron, 4 sulfur cluster binding
SMUL_3031	COG0243	molybdopterin cofactor binding
SMUL_3036	COG5002	protein histidine kinase activity
SMUL_3036	COG3850	Histidine kinase
SMUL_3037	COG1012	belongs to the aldehyde dehydrogenase family
SMUL_3040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMUL_3043	COG2183	response to ionizing radiation
SMUL_3049	COG0840	transmembrane signaling receptor activity
SMUL_3050	COG0778	Nitroreductase
SMUL_3057	COG0577	efflux transmembrane transporter activity
SMUL_3058	COG1136	(ABC) transporter
SMUL_3063	COG1472	Belongs to the glycosyl hydrolase 3 family
SMUL_3065	COG0475	glutathione-regulated potassium exporter activity
SMUL_3066	COG1280	lysine exporter protein (LysE YggA)
SMUL_3069	COG0454	-acetyltransferase
SMUL_3070	COG0431	NADPH-dependent FMN reductase
SMUL_3074	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMUL_3075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMUL_3079	COG0745	RESPONSE REGULATOR receiver
SMUL_3081	COG3842	ATPase activity
SMUL_3083	COG1840	ABC-type Fe3 transport system, periplasmic component
SMUL_3086	COG0175	sulfate reduction
SMUL_3087	COG0175	sulfate reduction
SMUL_3088	COG2895	sulfate adenylyltransferase (ATP) activity
SMUL_3090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SMUL_3092	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMUL_3094	COG2873	o-acetylhomoserine
SMUL_3096	COG0482	sulfurtransferase activity
SMUL_3101	COG5002	protein histidine kinase activity
SMUL_3103	COG2203	Gaf domain
SMUL_3103	COG2199	diguanylate cyclase activity
SMUL_3106	COG0745	RESPONSE REGULATOR receiver
SMUL_3115	COG4232	protein-disulfide reductase activity
SMUL_3116	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMUL_3117	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SMUL_3118	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMUL_3120	COG0243	molybdopterin cofactor binding
SMUL_3123	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMUL_3125	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SMUL_3132	COG0577	efflux transmembrane transporter activity
SMUL_3132	COG1136	(ABC) transporter
SMUL_3141	COG1136	(ABC) transporter
SMUL_3142	COG2204	response regulator
SMUL_3143	COG2205	protein histidine kinase activity
SMUL_3143	COG0745	RESPONSE REGULATOR receiver
SMUL_3143	COG4191	Histidine kinase
SMUL_3146	COG0243	molybdopterin cofactor binding
SMUL_3148	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SMUL_3149	COG0840	transmembrane signaling receptor activity
SMUL_3151	COG0861	Integral membrane protein TerC family
SMUL_3152	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMUL_3153	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMUL_3154	COG4303	Ethanolamine ammonia lyase large subunit
SMUL_3155	COG4302	ethanolamine ammonia-lyase activity
SMUL_3156	COG0531	amino acid
SMUL_3157	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMUL_3158	COG0281	malic enzyme
SMUL_3158	COG0280	phosphate acetyltransferase
SMUL_3161	COG0439	Biotin carboxylase
SMUL_3162	COG0511	ligase activity, forming carbon-carbon bonds
SMUL_3163	COG0717	Belongs to the dCTP deaminase family
SMUL_3166	COG3041	Addiction module toxin RelE StbE family
SMUL_3168	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMUL_3171	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMUL_3172	COG1086	Polysaccharide biosynthesis protein
SMUL_3173	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMUL_3174	COG1083	cytidylyl-transferase
SMUL_3176	COG2089	acid synthase
SMUL_3180	COG0318	PFAM AMP-dependent synthetase and ligase
SMUL_3181	COG1216	Glycosyl transferase, family 2
SMUL_3182	COG0562	UDP-galactopyranose mutase
SMUL_3184	COG1216	Glycosyl transferase, family 2
SMUL_3185	COG1216	Glycosyl transferase, family 2
SMUL_3186	COG0110	maltose O-acetyltransferase activity
SMUL_3188	COG2226	methyltransferase
SMUL_3194	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMUL_3195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMUL_3196	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SMUL_3197	COG0372	Belongs to the citrate synthase family
SMUL_3200	COG0148	phosphopyruvate hydratase activity
SMUL_3201	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SMUL_3202	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMUL_3203	COG1987	bacterial-type flagellum assembly
SMUL_3204	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMUL_3205	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMUL_3212	COG1408	metallophosphoesterase
SMUL_3213	COG1115	amino acid carrier protein
SMUL_3214	COG2233	PERMEase
SMUL_3215	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SMUL_3216	COG0575	Belongs to the CDS family
SMUL_3219	COG1929	Belongs to the glycerate kinase type-1 family
SMUL_3220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMUL_3225	COG0450	alkyl hydroperoxide reductase
SMUL_3226	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMUL_3228	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMUL_3229	COG0746	molybdenum cofactor guanylyltransferase activity
SMUL_3236	COG0724	RNA recognition motif
SMUL_3237	COG0315	cyclic pyranopterin monophosphate synthase activity
SMUL_3240	COG3328	transposase activity
SMUL_3248	COG3328	transposase activity
SMUL_3255	COG1140	nitrate reductase beta subunit
SMUL_3256	COG0243	molybdopterin cofactor binding
SMUL_3257	COG2897	thiosulfate sulfurtransferase activity
SMUL_3259	COG0489	protein tyrosine kinase activity
SMUL_3270	COG0670	Belongs to the BI1 family
SMUL_3281	COG0437	4 iron, 4 sulfur cluster binding
SMUL_3282	COG0243	molybdopterin cofactor binding
SMUL_3283	COG4106	trans-aconitate 2-methyltransferase activity
SMUL_3285	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMUL_3286	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SMUL_3288	COG0233	cytoplasmic translational termination
SMUL_3289	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMUL_3294	COG1704	LemA family
SMUL_3298	COG1749	Flagellar hook protein flgE
SMUL_3299	COG1749	Flagellar hook protein flgE
SMUL_3300	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SMUL_3301	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group