locus-tag	class	description
SMN_0002	COG0592	DNA-directed DNA polymerase activity
SMN_0003	COG0187	DNA topoisomerase II activity
SMN_0005	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMN_0007	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMN_0008	COG5001	Diguanylate cyclase
SMN_0008	COG3706	GGDEF domain
SMN_0008	COG2203	Gaf domain
SMN_0008	COG4251	negative regulation of phosphorylation
SMN_0010	COG4175	Glycine betaine
SMN_0011	COG4176	ABC-type proline glycine betaine transport system permease component
SMN_0012	COG2113	Glycine betaine
SMN_0013	COG2814	Major facilitator Superfamily
SMN_0014	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SMN_0017	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMN_0018	COG0066	3-isopropylmalate dehydratase activity
SMN_0026	COG2801	Transposase and inactivated derivatives
SMN_0030	COG3328	transposase activity
SMN_0042	COG0840	transmembrane signaling receptor activity
SMN_0047	COG2801	Transposase and inactivated derivatives
SMN_0049	COG0745	RESPONSE REGULATOR receiver
SMN_0050	COG3328	transposase activity
SMN_0054	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SMN_0057	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMN_0058	COG1335	isochorismatase
SMN_0061	COG2207	Transcriptional regulator
SMN_0062	COG1053	succinate dehydrogenase
SMN_0063	COG0039	L-malate dehydrogenase activity
SMN_0067	COG1355	regulation of microtubule-based process
SMN_0072	COG2169	Transcriptional regulator
SMN_0072	COG1917	Cupin 2, conserved barrel domain protein
SMN_0074	COG3150	esterase
SMN_0075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMN_0077	COG3383	formate dehydrogenase (NAD+) activity
SMN_0078	COG3706	GGDEF domain
SMN_0088	COG2095	MarC family integral membrane protein
SMN_0091	COG1120	ATPase activity
SMN_0092	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMN_0099	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMN_0100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMN_0101	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMN_0105	COG1328	CTP reductase activity
SMN_0105	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMN_0106	COG1794	racemase activity, acting on amino acids and derivatives
SMN_0107	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMN_0108	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMN_0109	COG0564	pseudouridine synthase activity
SMN_0110	COG0179	Fumarylacetoacetate (FAA) hydrolase
SMN_0111	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMN_0113	COG0107	imidazoleglycerol-phosphate synthase activity
SMN_0115	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SMN_0116	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SMN_0116	COG0517	IMP dehydrogenase activity
SMN_0117	COG1187	pseudouridine synthase activity
SMN_0118	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMN_0118	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SMN_0120	COG2257	FlhB HrpN YscU SpaS Family
SMN_0122	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMN_0123	COG0237	dephospho-CoA kinase activity
SMN_0124	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SMN_0126	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMN_0127	COG0268	Binds directly to 16S ribosomal RNA
SMN_0130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMN_0131	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SMN_0132	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMN_0133	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMN_0134	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMN_0135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMN_0136	COG0348	domain, Protein
SMN_0141	COG0754	glutathionylspermidine amidase activity
SMN_0144	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SMN_0150	COG5002	protein histidine kinase activity
SMN_0151	COG0745	RESPONSE REGULATOR receiver
SMN_0154	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SMN_0155	COG1127	ABC transporter
SMN_0156	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SMN_0158	COG2095	MarC family integral membrane protein
SMN_0159	COG0840	transmembrane signaling receptor activity
SMN_0159	COG3290	protein histidine kinase activity
SMN_0161	COG0784	Response regulator, receiver
SMN_0161	COG3437	response regulator, receiver
SMN_0162	COG0784	Response regulator, receiver
SMN_0162	COG3437	response regulator, receiver
SMN_0167	COG0745	RESPONSE REGULATOR receiver
SMN_0170	COG0004	ammonium transporteR
SMN_0173	COG0667	Aldo Keto reductase
SMN_0175	COG0745	RESPONSE REGULATOR receiver
SMN_0178	COG0765	amino acid transport
SMN_0183	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMN_0184	COG1121	(ABC) transporter
SMN_0188	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SMN_0190	COG0318	PFAM AMP-dependent synthetase and ligase
SMN_0191	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMN_0192	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_0193	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_0194	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_0195	COG0649	NAD binding
SMN_0199	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMN_0200	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_0201	COG0839	Belongs to the complex I subunit 6 family
SMN_0202	COG0713	ATP synthesis coupled electron transport
SMN_0203	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMN_0204	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_0205	COG1007	ATP synthesis coupled electron transport
SMN_0207	COG1012	belongs to the aldehyde dehydrogenase family
SMN_0208	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMN_0212	COG0840	transmembrane signaling receptor activity
SMN_0214	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMN_0215	COG0303	'Molybdopterin
SMN_0217	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SMN_0218	COG0254	rRNA binding
SMN_0219	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SMN_0223	COG0436	Aminotransferase
SMN_0224	COG0460	homoserine dehydrogenase
SMN_0225	COG0792	nuclease activity
SMN_0226	COG3118	belongs to the thioredoxin family
SMN_0227	COG0492	ferredoxin-NADP+ reductase activity
SMN_0228	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMN_0229	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SMN_0230	COG1242	4 iron, 4 sulfur cluster binding
SMN_0233	COG0140	phosphoribosyl-ATP diphosphatase activity
SMN_0233	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMN_0236	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SMN_0238	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMN_0239	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMN_0240	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMN_0241	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMN_0242	COG1077	Cell shape determining protein MreB Mrl
SMN_0244	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMN_0249	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SMN_0250	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SMN_0251	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMN_0255	COG4974	Belongs to the 'phage' integrase family
SMN_0258	COG2963	transposase activity
SMN_0259	COG2801	Transposase and inactivated derivatives
SMN_0260	COG3328	transposase activity
SMN_0261	COG2801	Transposase and inactivated derivatives
SMN_0267	COG0437	4 iron, 4 sulfur cluster binding
SMN_0268	COG0243	molybdopterin cofactor binding
SMN_0271	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMN_0272	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMN_0274	COG0835	chemotaxis
SMN_0274	COG0784	Response regulator, receiver
SMN_0275	COG0643	Histidine kinase
SMN_0275	COG2198	Histidine kinase
SMN_0276	COG0835	chemotaxis
SMN_0278	COG0560	Phosphoserine phosphatase
SMN_0284	COG0193	aminoacyl-tRNA hydrolase activity
SMN_0286	COG0019	diaminopimelate decarboxylase activity
SMN_0287	COG1605	Chorismate mutase
SMN_0287	COG0077	Prephenate dehydratase
SMN_0288	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMN_0290	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMN_0292	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMN_0294	COG0450	alkyl hydroperoxide reductase
SMN_0295	COG0840	transmembrane signaling receptor activity
SMN_0297	COG0105	UTP biosynthetic process
SMN_0299	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SMN_0300	COG0416	fatty acid biosynthetic process
SMN_0301	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMN_0302	COG0287	Prephenate dehydrogenase
SMN_0303	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMN_0304	COG0248	Ppx GppA phosphatase
SMN_0305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMN_0307	COG0745	RESPONSE REGULATOR receiver
SMN_0309	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SMN_0311	COG0157	Belongs to the NadC ModD family
SMN_0312	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMN_0315	COG0850	regulation of cytokinetic process
SMN_0316	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SMN_0318	COG0083	homoserine kinase activity
SMN_0322	COG0779	Required for maturation of 30S ribosomal subunits
SMN_0323	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMN_0323	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMN_0325	COG5001	Diguanylate cyclase
SMN_0326	COG1278	Cold shock
SMN_0327	COG5002	protein histidine kinase activity
SMN_0330	COG3258	Cytochrome c
SMN_0332	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SMN_0332	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMN_0335	COG0243	molybdopterin cofactor binding
SMN_0336	COG0437	4 iron, 4 sulfur cluster binding
SMN_0337	COG3301	Polysulphide reductase, NrfD
SMN_0338	COG2200	EAL domain
SMN_0338	COG3287	FIST C domain
SMN_0338	COG2199	diguanylate cyclase activity
SMN_0340	COG0437	4 iron, 4 sulfur cluster binding
SMN_0341	COG3301	Polysulphide reductase, NrfD
SMN_0342	COG0745	RESPONSE REGULATOR receiver
SMN_0343	COG5002	protein histidine kinase activity
SMN_0345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMN_0347	COG1227	inorganic diphosphatase activity
SMN_0351	COG1570	exodeoxyribonuclease VII activity
SMN_0353	COG2203	Gaf domain
SMN_0353	COG2199	diguanylate cyclase activity
SMN_0355	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMN_0356	COG1028	Short-chain dehydrogenase reductase Sdr
SMN_0357	COG2207	Transcriptional regulator
SMN_0358	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMN_0359	COG0583	DNA-binding transcription factor activity
SMN_0360	COG2855	membrane
SMN_0361	COG0386	Belongs to the glutathione peroxidase family
SMN_0365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMN_0367	COG0402	S-adenosylhomocysteine deaminase activity
SMN_0368	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SMN_0369	COG0006	proline dipeptidase activity
SMN_0370	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SMN_0371	COG1419	protein localization to endoplasmic reticulum
SMN_0372	COG0455	bacterial-type flagellum organization
SMN_0374	COG1191	sigma factor activity
SMN_0375	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMN_0376	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMN_0376	COG1776	CheC inhibitor of MCP methylation
SMN_0377	COG1611	Belongs to the LOG family
SMN_0379	COG0463	Glycosyl transferase, family 2
SMN_0381	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMN_0382	COG2076	Multidrug Resistance protein
SMN_0385	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMN_0387	COG1040	competence protein
SMN_0393	COG2204	response regulator
SMN_0394	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMN_0396	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SMN_0397	COG0731	radical SAM domain protein
SMN_0401	COG0582	viral genome integration into host DNA
SMN_0405	COG3328	transposase activity
SMN_0411	COG3328	transposase activity
SMN_0430	COG0419	ATPase involved in DNA repair
SMN_0432	COG3328	transposase activity
SMN_0437	COG0039	L-malate dehydrogenase activity
SMN_0439	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SMN_0440	COG1834	amidinotransferase
SMN_0442	COG0693	protein deglycase activity
SMN_0448	COG2199	diguanylate cyclase activity
SMN_0448	COG2200	EAL domain
SMN_0448	COG3287	FIST C domain
SMN_0451	COG3118	belongs to the thioredoxin family
SMN_0458	COG4628	conserved protein (DUF2132)
SMN_0459	COG4221	oxidoreductase activity
SMN_0462	COG0683	leucine binding
SMN_0463	COG0559	Belongs to the binding-protein-dependent transport system permease family
SMN_0466	COG0410	ABC transporter
SMN_0467	COG1012	belongs to the aldehyde dehydrogenase family
SMN_0470	COG3022	response to hydroperoxide
SMN_0475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMN_0476	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMN_0478	COG0250	Participates in transcription elongation, termination and antitermination
SMN_0479	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMN_0480	COG0081	regulation of translation
SMN_0481	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMN_0482	COG0222	ribosome binding
SMN_0483	COG0085	RNA polymerase activity
SMN_0484	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMN_0485	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMN_0489	COG2011	ABC-type metal ion transport system permease component
SMN_0490	COG1464	Belongs to the NlpA lipoprotein family
SMN_0493	COG1522	sequence-specific DNA binding
SMN_0494	COG0697	spore germination
SMN_0500	COG0745	RESPONSE REGULATOR receiver
SMN_0503	COG0840	transmembrane signaling receptor activity
SMN_0504	COG0840	transmembrane signaling receptor activity
SMN_0506	COG1034	ATP synthesis coupled electron transport
SMN_0507	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMN_0508	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_0509	COG0839	Belongs to the complex I subunit 6 family
SMN_0510	COG0713	ATP synthesis coupled electron transport
SMN_0511	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMN_0512	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_0513	COG1007	ATP synthesis coupled electron transport
SMN_0517	COG0649	NAD binding
SMN_0517	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_0518	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_0519	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_0522	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SMN_0526	COG0357	Ribosomal RNA small subunit methyltransferase G
SMN_0527	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMN_0528	COG1970	mechanosensitive ion channel activity
SMN_0530	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMN_0531	COG0113	porphobilinogen synthase activity
SMN_0532	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMN_0534	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMN_0535	COG0247	lactate metabolic process
SMN_0540	COG2026	Addiction module toxin, RelE StbE family
SMN_0541	COG3706	GGDEF domain
SMN_0542	COG2814	Major facilitator Superfamily
SMN_0543	COG3012	SEC-C Motif Domain Protein
SMN_0546	COG3706	GGDEF domain
SMN_0547	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMN_0549	COG1053	succinate dehydrogenase
SMN_0550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SMN_0552	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SMN_0553	COG0628	permease
SMN_0554	COG2255	four-way junction helicase activity
SMN_0555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SMN_0557	COG0159	tryptophan synthase activity
SMN_0561	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMN_0562	COG1136	(ABC) transporter
SMN_0563	COG1684	flagellar biosynthetic protein fliR
SMN_0565	COG0194	GDP metabolic process
SMN_0566	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMN_0567	COG0018	arginyl-trna synthetase
SMN_0569	COG2199	diguanylate cyclase activity
SMN_0569	COG3287	FIST C domain
SMN_0569	COG2200	EAL domain
SMN_0572	COG0735	belongs to the Fur family
SMN_0574	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMN_0575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SMN_0577	COG0149	triose-phosphate isomerase activity
SMN_0578	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SMN_0581	COG0195	Participates in both transcription termination and antitermination
SMN_0588	COG0037	tRNA processing
SMN_0589	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMN_0590	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SMN_0591	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SMN_0596	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMN_0597	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SMN_0598	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMN_0600	COG1151	hydroxylamine reductase activity
SMN_0606	COG2326	polyphosphate kinase activity
SMN_0611	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMN_0614	COG0513	Belongs to the DEAD box helicase family
SMN_0615	COG2610	gluconate transmembrane transporter activity
SMN_0616	COG1944	ATP diphosphatase activity
SMN_0618	COG4191	Histidine kinase
SMN_0619	COG2204	response regulator
SMN_0621	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
SMN_0624	COG2361	Protein of unknown function DUF86
SMN_0637	COG0559	Belongs to the binding-protein-dependent transport system permease family
SMN_0641	COG1333	cytochrome c biogenesis protein
SMN_0641	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMN_0649	COG1546	Belongs to the CinA family
SMN_0649	COG1058	Belongs to the CinA family
SMN_0650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMN_0653	COG0516	GMP reductase activity
SMN_0653	COG0517	IMP dehydrogenase activity
SMN_0654	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SMN_0657	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SMN_0658	COG0436	Aminotransferase
SMN_0661	COG1193	negative regulation of DNA recombination
SMN_0662	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMN_0663	COG0251	oxidation-reduction process
SMN_0664	COG0579	oxidoreductase
SMN_0667	COG0456	acetyltransferase
SMN_0667	COG0454	-acetyltransferase
SMN_0668	COG0793	Belongs to the peptidase S41A family
SMN_0668	COG3409	Peptidoglycan-binding domain 1 protein
SMN_0670	COG0469	pyruvate kinase activity
SMN_0671	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMN_0672	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMN_0673	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMN_0674	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMN_0675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMN_0677	COG1192	Involved in chromosome partitioning
SMN_0678	COG1475	DNA binding
SMN_0680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMN_0681	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMN_0683	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMN_0686	COG0811	peptide transport
SMN_0687	COG0848	biopolymer transport protein
SMN_0689	COG0823	Involved in the tonB-independent uptake of proteins
SMN_0690	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SMN_0690	COG2885	chlorophyll binding
SMN_0692	COG1047	Peptidyl-prolyl cis-trans
SMN_0694	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMN_0695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SMN_0696	COG0037	tRNA processing
SMN_0698	COG0067	glutamate synthase
SMN_0698	COG0070	glutamate synthase
SMN_0698	COG0069	glutamate synthase activity
SMN_0699	COG0493	'glutamate synthase
SMN_0701	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SMN_0702	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SMN_0703	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SMN_0705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMN_0709	COG1776	CheC inhibitor of MCP methylation
SMN_0709	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMN_0712	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SMN_0714	COG0748	coenzyme F420 binding
SMN_0721	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SMN_0723	COG1113	amino acid transport
SMN_0724	COG0730	response to heat
SMN_0725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMN_0726	COG1301	dicarboxylic acid transport
SMN_0728	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMN_0728	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMN_0729	COG1971	Probably functions as a manganese efflux pump
SMN_0731	COG0484	heat shock protein binding
SMN_0736	COG1271	oxidase subunit
SMN_0737	COG1294	oxidase, subunit
SMN_0738	COG0745	RESPONSE REGULATOR receiver
SMN_0740	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SMN_0742	COG0840	transmembrane signaling receptor activity
SMN_0743	COG0318	PFAM AMP-dependent synthetase and ligase
SMN_0744	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMN_0745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMN_0748	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMN_0749	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMN_0752	COG3706	GGDEF domain
SMN_0754	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMN_0761	COG0784	Response regulator, receiver
SMN_0761	COG2205	protein histidine kinase activity
SMN_0761	COG5002	protein histidine kinase activity
SMN_0764	COG0322	excinuclease ABC activity
SMN_0766	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SMN_0768	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMN_0768	COG0519	Catalyzes the synthesis of GMP from XMP
SMN_0770	COG0151	Belongs to the GarS family
SMN_0774	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMN_0782	COG0511	ligase activity, forming carbon-carbon bonds
SMN_0784	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SMN_0785	COG0165	Argininosuccinate lyase
SMN_0786	COG0537	adenosine 5'-monophosphoramidase activity
SMN_0787	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMN_0788	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMN_0788	COG0072	phenylalanine-tRNA ligase activity
SMN_0789	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMN_0790	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SMN_0791	COG0539	negative regulation of cytoplasmic translation
SMN_0791	COG1185	polyribonucleotide nucleotidyltransferase activity
SMN_0793	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMN_0795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMN_0797	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMN_0801	COG0840	transmembrane signaling receptor activity
SMN_0803	COG0840	transmembrane signaling receptor activity
SMN_0808	COG2081	HI0933 family
SMN_0817	COG3287	FIST C domain
SMN_0817	COG2200	EAL domain
SMN_0817	COG2199	diguanylate cyclase activity
SMN_0818	COG1902	pentaerythritol trinitrate reductase activity
SMN_0819	COG1538	Outer membrane efflux protein
SMN_0823	COG0840	transmembrane signaling receptor activity
SMN_0824	COG0840	transmembrane signaling receptor activity
SMN_0824	COG0840	transmembrane signaling receptor activity
SMN_0826	COG0587	DNA-directed DNA polymerase activity
SMN_0827	COG0517	IMP dehydrogenase activity
SMN_0830	COG4191	Histidine kinase
SMN_0832	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMN_0833	COG0569	domain protein
SMN_0836	COG0772	Belongs to the SEDS family
SMN_0837	COG0564	pseudouridine synthase activity
SMN_0839	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMN_0843	COG0528	UMP kinase activity
SMN_0844	COG1758	RNA polymerase activity
SMN_0846	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SMN_0848	COG0860	N-Acetylmuramoyl-L-alanine amidase
SMN_0850	COG0563	adenylate kinase activity
SMN_0851	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMN_0852	COG0745	RESPONSE REGULATOR receiver
SMN_0852	COG3706	GGDEF domain
SMN_0854	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMN_0855	COG0497	DNA recombination
SMN_0856	COG1620	l-lactate permease
SMN_0857	COG3706	GGDEF domain
SMN_0858	COG0084	hydrolase, TatD family'
SMN_0859	COG1388	LysM domain
SMN_0859	COG3942	CHAP domain
SMN_0860	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMN_0861	COG0131	Imidazoleglycerol-phosphate dehydratase
SMN_0862	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SMN_0865	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SMN_0868	COG0768	penicillin binding
SMN_0870	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMN_0872	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMN_0872	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMN_0874	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SMN_0879	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMN_0880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMN_0882	COG3005	denitrification pathway
SMN_0884	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMN_0884	COG1333	cytochrome c biogenesis protein
SMN_0888	COG3545	Serine hydrolase
SMN_0890	COG1346	cytolysis
SMN_0893	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
SMN_0895	COG0398	Pfam SNARE associated Golgi protein
SMN_0897	COG0398	Pfam SNARE associated Golgi protein
SMN_0898	COG2226	methyltransferase
SMN_0905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMN_0906	COG4716	Myosin-crossreactive antigen
SMN_0908	COG4585	Histidine kinase
SMN_0911	COG0109	protoheme IX farnesyltransferase activity
SMN_0912	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMN_0915	COG1845	cytochrome c oxidase, subunit III
SMN_0915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMN_0922	COG4804	nuclease activity
SMN_0925	COG0243	molybdopterin cofactor binding
SMN_0926	COG0437	4 iron, 4 sulfur cluster binding
SMN_0927	COG0348	domain, Protein
SMN_0928	COG3043	anaerobic respiration
SMN_0929	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMN_0929	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMN_0938	COG1595	DNA-templated transcription, initiation
SMN_0941	COG0243	molybdopterin cofactor binding
SMN_0944	COG0745	RESPONSE REGULATOR receiver
SMN_0946	COG3852	Histidine kinase
SMN_0947	COG2863	cytochrome
SMN_0948	COG0723	plastoquinol--plastocyanin reductase activity
SMN_0949	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMN_0953	COG2199	diguanylate cyclase activity
SMN_0953	COG3287	FIST C domain
SMN_0953	COG2200	EAL domain
SMN_0954	COG0688	phosphatidylethanolamine metabolic process
SMN_0955	COG0513	Belongs to the DEAD box helicase family
SMN_0958	COG2964	Protein conserved in bacteria
SMN_0959	COG2084	Dehydrogenase
SMN_0962	COG0437	4 iron, 4 sulfur cluster binding
SMN_0964	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMN_0965	COG2258	MOSC domain
SMN_0966	COG1280	lysine exporter protein (LysE YggA)
SMN_0967	COG3437	response regulator, receiver
SMN_0967	COG0784	Response regulator, receiver
SMN_0969	COG0217	transcriptional regulatory protein
SMN_0974	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMN_0985	COG2801	Transposase and inactivated derivatives
SMN_0986	COG2963	transposase activity
SMN_0987	COG1696	Membrane protein involved in D-alanine export
SMN_0997	COG1305	Transglutaminase-like
SMN_1001	COG1305	Transglutaminase-like
SMN_1003	COG2308	Evidence 4 Homologs of previously reported genes of
SMN_1005	COG2966	Psort location CytoplasmicMembrane, score
SMN_1006	COG3610	response to peptide
SMN_1007	COG2703	oxygen carrier activity
SMN_1008	COG2217	Heavy metal translocating P-type atpase
SMN_1009	COG0640	Transcriptional regulator
SMN_1010	COG1280	lysine exporter protein (LysE YggA)
SMN_1012	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMN_1013	COG2169	Transcriptional regulator
SMN_1013	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMN_1015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMN_1017	COG0840	transmembrane signaling receptor activity
SMN_1017	COG3290	protein histidine kinase activity
SMN_1019	COG0352	thiamine-phosphate diphosphorylase activity
SMN_1022	COG1272	protein, Hemolysin III
SMN_1025	COG0247	lactate metabolic process
SMN_1027	COG1556	Lactate utilization protein
SMN_1028	COG0697	spore germination
SMN_1032	COG2176	DNA-directed DNA polymerase activity
SMN_1037	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SMN_1039	COG0501	Belongs to the peptidase M48B family
SMN_1043	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SMN_1044	COG2201	protein-glutamate methylesterase activity
SMN_1045	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMN_1046	COG0586	Pfam SNARE associated Golgi protein
SMN_1047	COG0133	tryptophan synthase activity
SMN_1048	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMN_1050	COG0698	ribose 5-phosphate isomerase
SMN_1051	COG1994	Peptidase M50
SMN_1052	COG0681	Belongs to the peptidase S26 family
SMN_1053	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMN_1073	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMN_1076	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMN_1077	COG0612	Peptidase, M16
SMN_1078	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SMN_1084	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
SMN_1085	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMN_1086	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SMN_1087	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMN_1088	COG0629	single-stranded DNA binding
SMN_1089	COG0360	Binds together with S18 to 16S ribosomal RNA
SMN_1090	COG1466	dna polymerase III delta subunit
SMN_1091	COG0557	exoribonuclease II activity
SMN_1093	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMN_1094	COG2894	cell division
SMN_1095	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SMN_1097	COG0758	DNA mediated transformation
SMN_1098	COG0730	response to heat
SMN_1099	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMN_1102	COG1760	l-serine dehydratase
SMN_1103	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMN_1104	COG2860	membrane
SMN_1105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMN_1108	COG0736	holo-[acyl-carrier-protein] synthase activity
SMN_1109	COG1580	Controls the rotational direction of flagella during chemotaxis
SMN_1110	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SMN_1111	COG0552	protein localization to endoplasmic reticulum
SMN_1112	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMN_1114	COG1418	mRNA catabolic process
SMN_1115	COG1132	(ABC) transporter
SMN_1117	COG0586	Pfam SNARE associated Golgi protein
SMN_1120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SMN_1123	COG0745	RESPONSE REGULATOR receiver
SMN_1125	COG5002	protein histidine kinase activity
SMN_1125	COG5001	Diguanylate cyclase
SMN_1126	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMN_1126	COG4191	Histidine kinase
SMN_1129	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMN_1137	COG1518	maintenance of DNA repeat elements
SMN_1159	COG3328	transposase activity
SMN_1163	COG1450	Type ii and iii secretion system protein
SMN_1170	COG5002	protein histidine kinase activity
SMN_1171	COG1408	metallophosphoesterase
SMN_1172	COG2353	YceI-like domain
SMN_1175	COG1136	(ABC) transporter
SMN_1178	COG4456	Virulence-associated protein
SMN_1183	COG3328	transposase activity
SMN_1189	COG0242	peptide deformylase activity
SMN_1190	COG0824	Thioesterase
SMN_1192	COG1573	uracil-dna glycosylase
SMN_1195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMN_1199	COG2199	diguanylate cyclase activity
SMN_1199	COG3287	FIST C domain
SMN_1199	COG2200	EAL domain
SMN_1201	COG0745	RESPONSE REGULATOR receiver
SMN_1202	COG0426	domain, Protein
SMN_1207	COG2040	homocysteine
SMN_1208	COG1012	belongs to the aldehyde dehydrogenase family
SMN_1209	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SMN_1209	COG3264	Mechanosensitive ion channel
SMN_1211	COG0784	Response regulator, receiver
SMN_1211	COG2205	protein histidine kinase activity
SMN_1212	COG3437	response regulator, receiver
SMN_1214	COG1433	Dinitrogenase iron-molybdenum cofactor
SMN_1221	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SMN_1228	COG2026	Addiction module toxin, RelE StbE family
SMN_1229	COG3645	SOS response
SMN_1240	COG1451	nucleotide metabolic process
SMN_1250	COG0697	spore germination
SMN_1252	COG3706	GGDEF domain
SMN_1253	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMN_1260	COG0840	transmembrane signaling receptor activity
SMN_1261	COG0840	transmembrane signaling receptor activity
SMN_1262	COG0243	molybdopterin cofactor binding
SMN_1265	COG0747	negative chemotaxis
SMN_1269	COG1276	copper resistance
SMN_1270	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SMN_1276	COG0745	RESPONSE REGULATOR receiver
SMN_1278	COG3153	acetyltransferase
SMN_1278	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMN_1286	COG5002	protein histidine kinase activity
SMN_1289	COG0493	'glutamate synthase
SMN_1290	COG0375	protein maturation
SMN_1291	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMN_1293	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_1295	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_1298	COG2814	Major facilitator Superfamily
SMN_1304	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMN_1306	COG1131	(ABC) transporter
SMN_1307	COG0842	Transport permease protein
SMN_1308	COG4456	Virulence-associated protein
SMN_1314	COG0667	Aldo Keto reductase
SMN_1315	COG1053	succinate dehydrogenase
SMN_1322	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SMN_1323	COG0585	pseudouridine synthase activity
SMN_1324	COG0475	glutathione-regulated potassium exporter activity
SMN_1324	COG0569	domain protein
SMN_1328	COG2199	diguanylate cyclase activity
SMN_1328	COG2203	Gaf domain
SMN_1329	COG0352	thiamine-phosphate diphosphorylase activity
SMN_1329	COG0351	phosphomethylpyrimidine kinase
SMN_1331	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SMN_1333	COG0428	transporter
SMN_1335	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMN_1337	COG0840	transmembrane signaling receptor activity
SMN_1338	COG1234	tRNA 3'-trailer cleavage
SMN_1340	COG0488	(ABC) transporter
SMN_1342	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SMN_1343	COG1309	transcriptional regulator
SMN_1346	COG1538	Outer membrane efflux protein
SMN_1349	COG0778	Nitroreductase
SMN_1350	COG0778	Nitroreductase
SMN_1351	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMN_1355	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SMN_1360	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SMN_1364	COG4145	pantothenate transmembrane transporter activity
SMN_1367	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SMN_1370	COG0742	ribosomal rna small subunit methyltransferase
SMN_1371	COG1706	bacterial-type flagellum-dependent cell motility
SMN_1372	COG3951	Flagellar rod assembly protein muramidase FlgJ
SMN_1376	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMN_1378	COG0659	secondary active sulfate transmembrane transporter activity
SMN_1379	COG1942	4-Oxalocrotonate Tautomerase
SMN_1380	COG0356	it plays a direct role in the translocation of protons across the membrane
SMN_1384	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMN_1387	COG0101	tRNA pseudouridine synthase activity
SMN_1389	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SMN_1391	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SMN_1392	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMN_1393	COG1338	Plays a role in the flagellum-specific transport system
SMN_1394	COG0676	glucose-6-phosphate 1-epimerase activity
SMN_1395	COG1733	regulation of RNA biosynthetic process
SMN_1396	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMN_1398	COG4269	membrane
SMN_1401	COG3174	membrane
SMN_1402	COG1032	radical SAM domain protein
SMN_1403	COG0166	Belongs to the GPI family
SMN_1408	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
SMN_1409	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SMN_1410	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
SMN_1411	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SMN_1412	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SMN_1413	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SMN_1415	COG4774	siderophore transport
SMN_1419	COG0298	carbon dioxide binding
SMN_1420	COG0409	Hydrogenase expression formation protein
SMN_1421	COG0309	Hydrogenase expression formation protein (HypE)
SMN_1423	COG1247	-acetyltransferase
SMN_1424	COG0546	phosphoglycolate phosphatase activity
SMN_1428	COG0039	L-malate dehydrogenase activity
SMN_1429	COG0745	RESPONSE REGULATOR receiver
SMN_1430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMN_1430	COG2205	protein histidine kinase activity
SMN_1432	COG0471	metal ion transport
SMN_1433	COG0247	lactate metabolic process
SMN_1434	COG0277	FAD linked oxidase domain protein
SMN_1435	COG0045	succinate-CoA ligase (ADP-forming) activity
SMN_1436	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SMN_1438	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SMN_1438	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMN_1439	COG3962	Belongs to the TPP enzyme family
SMN_1444	COG0114	fumarate hydratase activity
SMN_1447	COG2095	MarC family integral membrane protein
SMN_1451	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMN_1452	COG0750	zinc metalloprotease
SMN_1453	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMN_1454	COG1028	Short-chain dehydrogenase reductase Sdr
SMN_1455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMN_1457	COG0167	dihydroorotate dehydrogenase activity
SMN_1458	COG1132	(ABC) transporter
SMN_1459	COG0215	cysteine-tRNA ligase activity
SMN_1460	COG0728	peptidoglycan biosynthetic process
SMN_1462	COG0632	four-way junction helicase activity
SMN_1463	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMN_1467	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMN_1468	COG0280	phosphate acetyltransferase
SMN_1468	COG0857	belongs to the CobB CobQ family
SMN_1469	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SMN_1482	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SMN_1483	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SMN_1486	COG0137	argininosuccinate synthase activity
SMN_1487	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SMN_1488	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMN_1489	COG0802	atpase or kinase
SMN_1490	COG1137	ATPase activity
SMN_1491	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SMN_1496	COG0419	ATPase involved in DNA repair
SMN_1497	COG1196	nuclear chromosome segregation
SMN_1511	COG1053	succinate dehydrogenase
SMN_1519	COG3852	Histidine kinase
SMN_1523	COG0784	Response regulator, receiver
SMN_1523	COG4191	Histidine kinase
SMN_1527	COG0437	4 iron, 4 sulfur cluster binding
SMN_1529	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SMN_1531	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
SMN_1535	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SMN_1539	COG1120	ATPase activity
SMN_1542	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SMN_1546	COG2875	Belongs to the precorrin methyltransferase family
SMN_1551	COG1132	(ABC) transporter
SMN_1552	COG1797	cobyrinic acid a,c-diamide synthase activity
SMN_1553	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SMN_1553	COG1648	precorrin-2 dehydrogenase activity
SMN_1577	COG0582	viral genome integration into host DNA
SMN_1579	COG0776	regulation of translation
SMN_1580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMN_1581	COG1674	ftsk spoiiie
SMN_1581	COG1196	nuclear chromosome segregation
SMN_1582	COG1049	propionate catabolic process, 2-methylcitrate cycle
SMN_1583	COG1047	Peptidyl-prolyl cis-trans
SMN_1584	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMN_1584	COG0574	Belongs to the PEP-utilizing enzyme family
SMN_1585	COG2814	Major facilitator Superfamily
SMN_1589	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMN_1591	COG1832	CoA-binding protein
SMN_1592	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMN_1594	COG1126	abc transporter atp-binding protein
SMN_1595	COG0765	amino acid transport
SMN_1596	COG4597	amino acid ABC transporter
SMN_1597	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMN_1598	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SMN_1601	COG0586	Pfam SNARE associated Golgi protein
SMN_1604	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMN_1607	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SMN_1608	COG0727	PFAM Uncharacterised protein family (UPF0153)
SMN_1610	COG0134	indole-3-glycerol-phosphate synthase activity
SMN_1612	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SMN_1614	COG0310	cobalt ion transport
SMN_1618	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SMN_1619	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SMN_1622	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMN_1624	COG0248	Ppx GppA phosphatase
SMN_1625	COG0028	Belongs to the TPP enzyme family
SMN_1627	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMN_1629	COG0493	'glutamate synthase
SMN_1630	COG0436	Aminotransferase
SMN_1631	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SMN_1637	COG1045	serine acetyltransferase
SMN_1638	COG1166	arginine decarboxylase activity
SMN_1639	COG0124	histidyl-tRNA synthetase
SMN_1641	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMN_1642	COG0163	prenyltransferase activity
SMN_1644	COG0840	transmembrane signaling receptor activity
SMN_1645	COG0303	'Molybdopterin
SMN_1646	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMN_1653	COG0489	protein tyrosine kinase activity
SMN_1655	COG1342	Belongs to the UPF0251 family
SMN_1656	COG1691	(AIR) carboxylase
SMN_1657	COG1606	tRNA processing
SMN_1658	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SMN_1659	COG3875	lactate racemase activity
SMN_1660	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SMN_1660	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SMN_1662	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SMN_1668	COG0582	viral genome integration into host DNA
SMN_1669	COG0343	queuine tRNA-ribosyltransferase activity
SMN_1671	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SMN_1673	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMN_1674	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMN_1678	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMN_1681	COG2378	regulation of single-species biofilm formation
SMN_1682	COG1187	pseudouridine synthase activity
SMN_1683	COG0028	Belongs to the TPP enzyme family
SMN_1685	COG2066	Belongs to the glutaminase family
SMN_1689	COG1309	transcriptional regulator
SMN_1695	COG0840	transmembrane signaling receptor activity
SMN_1716	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMN_1720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMN_1743	COG3328	transposase activity
SMN_1754	COG0582	viral genome integration into host DNA
SMN_1759	COG0776	regulation of translation
SMN_1797	COG3344	reverse transcriptase
SMN_1810	COG0629	single-stranded DNA binding
SMN_1853	COG4774	siderophore transport
SMN_1875	COG0582	viral genome integration into host DNA
SMN_1877	COG1592	Rubrerythrin
SMN_1879	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SMN_1880	COG0181	hydroxymethylbilane synthase activity
SMN_1883	COG0442	prolyl-tRNA aminoacylation
SMN_1884	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SMN_1885	COG0142	geranyltranstransferase activity
SMN_1889	COG1959	2 iron, 2 sulfur cluster binding
SMN_1891	COG3706	GGDEF domain
SMN_1892	COG0525	valine-tRNA ligase activity
SMN_1893	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SMN_1894	COG0521	Mo-molybdopterin cofactor biosynthetic process
SMN_1896	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMN_1899	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMN_1900	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SMN_1902	COG2195	Cleaves the N-terminal amino acid of tripeptides
SMN_1904	COG0500	methyltransferase
SMN_1907	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMN_1908	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMN_1909	COG1663	tetraacyldisaccharide 4'-kinase activity
SMN_1910	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMN_1911	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SMN_1912	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SMN_1915	COG4232	protein-disulfide reductase activity
SMN_1917	COG0443	Heat shock 70 kDa protein
SMN_1918	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMN_1919	COG1420	regulation of RNA biosynthetic process
SMN_1922	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMN_1923	COG1959	2 iron, 2 sulfur cluster binding
SMN_1924	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMN_1925	COG2404	hydrolase activity, acting on ester bonds
SMN_1927	COG2226	methyltransferase
SMN_1928	COG3706	GGDEF domain
SMN_1929	COG0196	riboflavin kinase activity
SMN_1930	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMN_1931	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMN_1932	COG0730	response to heat
SMN_1934	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SMN_1937	COG0527	aspartate kinase activity
SMN_1938	COG0494	nUDIX hydrolase
SMN_1939	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMN_1941	COG0789	Transcriptional regulator
SMN_1942	COG0484	heat shock protein binding
SMN_1943	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMN_1944	COG0745	RESPONSE REGULATOR receiver
SMN_1945	COG5002	protein histidine kinase activity
SMN_1948	COG0653	protein targeting
SMN_1951	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SMN_1952	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SMN_1954	COG0706	membrane insertase activity
SMN_1955	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SMN_1958	COG4865	methylaspartate mutase activity
SMN_1984	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SMN_1987	COG0542	response to heat
SMN_1988	COG0793	Belongs to the peptidase S41A family
SMN_1990	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMN_1991	COG0047	phosphoribosylformylglycinamidine synthase activity
SMN_1993	COG0204	Acyl-transferase
SMN_1994	COG0326	Molecular chaperone. Has ATPase activity
SMN_1995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMN_1999	COG1331	Highly conserved protein containing a thioredoxin domain
SMN_2000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMN_2008	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMN_2013	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SMN_2015	COG2608	mercury ion transmembrane transporter activity
SMN_2016	COG2217	Heavy metal translocating P-type atpase
SMN_2017	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMN_2020	COG0275	rRNA processing
SMN_2022	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMN_2023	COG0849	cell division
SMN_2024	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SMN_2026	COG2890	protein-(glutamine-N5) methyltransferase activity
SMN_2027	COG0501	Belongs to the peptidase M48B family
SMN_2030	COG0840	transmembrane signaling receptor activity
SMN_2032	COG2151	metal-sulfur cluster biosynthetic enzyme
SMN_2035	COG0138	bifunctional purine biosynthesis protein purh
SMN_2036	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SMN_2038	COG1607	acyl-coa hydrolase
SMN_2039	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SMN_2040	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SMN_2044	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMN_2046	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMN_2047	COG0805	protein transport
SMN_2048	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SMN_2052	COG3328	transposase activity
SMN_2055	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SMN_2057	COG0765	amino acid transport
SMN_2060	COG3437	response regulator, receiver
SMN_2062	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMN_2063	COG1022	Amp-dependent synthetase and ligase
SMN_2065	COG4206	TonB-dependent receptor
SMN_2066	COG2205	protein histidine kinase activity
SMN_2067	COG0745	RESPONSE REGULATOR receiver
SMN_2068	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMN_2069	COG0569	domain protein
SMN_2070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMN_2073	COG2068	MobA-Related Protein
SMN_2074	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SMN_2074	COG3608	succinylglutamate desuccinylase aspartoacylase
SMN_2075	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SMN_2076	COG0535	radical SAM domain protein
SMN_2082	COG0642	Histidine kinase
SMN_2085	COG3038	cytochrome b561
SMN_2088	COG0745	RESPONSE REGULATOR receiver
SMN_2090	COG1230	cation diffusion facilitator family transporter
SMN_2094	COG4774	siderophore transport
SMN_2096	COG0668	transmembrane transport
SMN_2103	COG4263	nitrous-oxide reductase activity
SMN_2106	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SMN_2108	COG0646	methionine synthase
SMN_2108	COG1410	methionine synthase
SMN_2111	COG0840	transmembrane signaling receptor activity
SMN_2112	COG1280	lysine exporter protein (LysE YggA)
SMN_2115	COG0004	ammonium transporteR
SMN_2116	COG0347	Belongs to the P(II) protein family
SMN_2118	COG1401	restriction endodeoxyribonuclease activity
SMN_2125	COG0288	reversible hydration of carbon dioxide
SMN_2126	COG3123	guanosine phosphorylase activity
SMN_2128	COG2081	HI0933 family
SMN_2130	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SMN_2131	COG0788	formyltetrahydrofolate deformylase activity
SMN_2132	COG0617	tRNA 3'-terminal CCA addition
SMN_2135	COG0473	3-isopropylmalate dehydrogenase activity
SMN_2136	COG0066	3-isopropylmalate dehydratase activity
SMN_2137	COG1119	ATPase activity
SMN_2141	COG0708	Exodeoxyribonuclease III
SMN_2144	COG0840	transmembrane signaling receptor activity
SMN_2146	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMN_2147	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
SMN_2148	COG3005	denitrification pathway
SMN_2149	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
SMN_2150	COG0840	transmembrane signaling receptor activity
SMN_2152	COG0745	RESPONSE REGULATOR receiver
SMN_2156	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SMN_2158	COG3706	GGDEF domain
SMN_2160	COG4895	conserved protein (DUF2196)
SMN_2164	COG0513	Belongs to the DEAD box helicase family
SMN_2166	COG5001	Diguanylate cyclase
SMN_2167	COG0642	Histidine kinase
SMN_2168	COG0745	RESPONSE REGULATOR receiver
SMN_2175	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SMN_2176	COG0372	Belongs to the citrate synthase family
SMN_2177	COG2079	MmgE PrpD family protein
SMN_2179	COG2824	Alkylphosphonate utilization operon protein PhnA
SMN_2181	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SMN_2182	COG4786	Flagellar basal body rod
SMN_2183	COG4786	Flagellar basal body rod
SMN_2184	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMN_2186	COG1733	regulation of RNA biosynthetic process
SMN_2189	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMN_2190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMN_2191	COG3162	membrane
SMN_2192	COG0745	RESPONSE REGULATOR receiver
SMN_2194	COG2957	Belongs to the agmatine deiminase family
SMN_2196	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SMN_2197	COG1918	ferrous iron import across plasma membrane
SMN_2202	COG3585	molybdate ion transport
SMN_2204	COG0598	Magnesium transport protein CorA
SMN_2205	COG0739	heme binding
SMN_2207	COG0277	FAD linked oxidase domain protein
SMN_2208	COG1295	ribonuclease BN
SMN_2210	COG0305	Participates in initiation and elongation during chromosome replication
SMN_2210	COG0305	Participates in initiation and elongation during chromosome replication
SMN_2211	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMN_2212	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SMN_2213	COG4969	Belongs to the N-Me-Phe pilin family
SMN_2217	COG0556	nucleotide-excision repair
SMN_2220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SMN_2221	COG2176	DNA-directed DNA polymerase activity
SMN_2222	COG0135	phosphoribosylanthranilate isomerase activity
SMN_2223	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SMN_2225	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMN_2228	COG1692	metallophosphoesterase
SMN_2229	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SMN_2231	COG0739	heme binding
SMN_2232	COG0285	dihydrofolate synthase activity
SMN_2233	COG3706	GGDEF domain
SMN_2235	COG0495	leucyl-tRNA aminoacylation
SMN_2236	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMN_2237	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMN_2238	COG1862	Preprotein translocase
SMN_2239	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SMN_2240	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMN_2242	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SMN_2243	COG0542	response to heat
SMN_2244	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SMN_2246	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMN_2247	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMN_2248	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SMN_2249	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SMN_2250	COG0210	DNA helicase
SMN_2256	COG0540	Belongs to the ATCase OTCase family
SMN_2258	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SMN_2265	COG0336	Belongs to the RNA methyltransferase TrmD family
SMN_2267	COG1837	Belongs to the UPF0109 family
SMN_2268	COG0228	four-way junction DNA binding
SMN_2269	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SMN_2270	COG0564	pseudouridine synthase activity
SMN_2271	COG1519	Transferase
SMN_2273	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SMN_2274	COG0752	glycyl-tRNA synthetase alpha subunit
SMN_2276	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SMN_2279	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SMN_2280	COG0174	glutamine synthetase
SMN_2282	COG0444	Belongs to the ABC transporter superfamily
SMN_2283	COG0156	8-amino-7-oxononanoate synthase activity
SMN_2284	COG0424	maF-like protein
SMN_2286	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMN_2288	COG0745	RESPONSE REGULATOR receiver
SMN_2289	COG5002	protein histidine kinase activity
SMN_2290	COG0243	molybdopterin cofactor binding
SMN_2291	COG0437	4 iron, 4 sulfur cluster binding
SMN_2292	COG3302	dmso reductase anchor subunit
SMN_2293	COG3381	protein complex oligomerization
SMN_2297	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SMN_2300	COG1558	bacterial-type flagellum-dependent cell motility
SMN_2301	COG1815	bacterial-type flagellum-dependent cell motility
SMN_2302	COG0772	Belongs to the SEDS family
SMN_2303	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMN_2306	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SMN_2317	COG2814	Major facilitator Superfamily
SMN_2318	COG0204	Acyl-transferase
SMN_2318	COG0318	PFAM AMP-dependent synthetase and ligase
SMN_2319	COG0640	Transcriptional regulator
SMN_2323	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
SMN_2325	COG2301	Belongs to the HpcH HpaI aldolase family
SMN_2327	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SMN_2328	COG3180	Ammonia monooxygenase
SMN_2330	COG3290	protein histidine kinase activity
SMN_2331	COG4565	transcriptional regulatory protein
SMN_2335	COG5002	protein histidine kinase activity
SMN_2335	COG0784	Response regulator, receiver
SMN_2335	COG2205	protein histidine kinase activity
SMN_2336	COG3437	response regulator, receiver
SMN_2337	COG2814	Major facilitator Superfamily
SMN_2339	COG2252	PERMEase
SMN_2340	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMN_2343	COG0133	tryptophan synthase activity
SMN_2346	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMN_2347	COG3706	GGDEF domain
SMN_2353	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMN_2358	COG0488	(ABC) transporter
SMN_2361	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMN_2362	COG0651	ATP synthesis coupled electron transport
SMN_2363	COG0650	Formate hydrogenlyase subunit 4
SMN_2364	COG4237	Hydrogenase 4 membrane
SMN_2365	COG0651	ATP synthesis coupled electron transport
SMN_2366	COG3261	NADH dehydrogenase
SMN_2366	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
SMN_2368	COG3260	NADH ubiquinone oxidoreductase 20
SMN_2373	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMN_2375	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SMN_2376	COG3706	GGDEF domain
SMN_2376	COG0745	RESPONSE REGULATOR receiver
SMN_2379	COG2171	N-acyltransferase activity
SMN_2380	COG0489	protein tyrosine kinase activity
SMN_2381	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SMN_2381	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SMN_2383	COG2046	Belongs to the sulfate adenylyltransferase family
SMN_2386	COG2353	YceI-like domain
SMN_2387	COG1739	Uncharacterized protein family UPF0029
SMN_2388	COG0157	Belongs to the NadC ModD family
SMN_2389	COG4208	sulfate ABC transporter
SMN_2391	COG3842	ATPase activity
SMN_2396	COG1686	Belongs to the peptidase S11 family
SMN_2397	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SMN_2398	COG1136	(ABC) transporter
SMN_2398	COG0577	efflux transmembrane transporter activity
SMN_2399	COG1136	(ABC) transporter
SMN_2399	COG0577	efflux transmembrane transporter activity
SMN_2400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMN_2404	COG0668	transmembrane transport
SMN_2420	COG0284	orotidine-5'-phosphate decarboxylase activity
SMN_2421	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMN_2422	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SMN_2425	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SMN_2426	COG0697	spore germination
SMN_2427	COG0668	transmembrane transport
SMN_2428	COG1160	GTP binding
SMN_2430	COG0180	Tryptophanyl-tRNA synthetase
SMN_2431	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMN_2433	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMN_2434	COG1183	phosphatidylcholine synthase activity
SMN_2436	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMN_2437	COG2264	protein methyltransferase activity
SMN_2439	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMN_2440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMN_2443	COG1086	Polysaccharide biosynthesis protein
SMN_2444	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMN_2447	COG0438	transferase activity, transferring glycosyl groups
SMN_2448	COG0110	maltose O-acetyltransferase activity
SMN_2451	COG0110	maltose O-acetyltransferase activity
SMN_2455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMN_2457	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMN_2458	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMN_2460	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SMN_2463	COG1793	dna ligase
SMN_2465	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SMN_2466	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMN_2475	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SMN_2476	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SMN_2476	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SMN_2477	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SMN_2481	COG2217	Heavy metal translocating P-type atpase
SMN_2481	COG2608	mercury ion transmembrane transporter activity
SMN_2482	COG5002	protein histidine kinase activity
SMN_2482	COG5001	Diguanylate cyclase
SMN_2483	COG0697	spore germination
SMN_2485	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SMN_2489	COG0840	transmembrane signaling receptor activity
SMN_2490	COG1984	allophanate hydrolase subunit 2
SMN_2492	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SMN_2496	COG0745	RESPONSE REGULATOR receiver
SMN_2497	COG0840	transmembrane signaling receptor activity
SMN_2498	COG0445	tRNA wobble uridine modification
SMN_2499	COG0723	plastoquinol--plastocyanin reductase activity
SMN_2503	COG0825	malonyl-CoA metabolic process
SMN_2504	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMN_2505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMN_2507	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SMN_2508	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMN_2509	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SMN_2511	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SMN_2515	COG0300	oxidoreductase activity
SMN_2516	COG0277	FAD linked oxidase domain protein
SMN_2518	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SMN_2519	COG2801	Transposase and inactivated derivatives
SMN_2534	COG1134	teichoic acid transport
SMN_2537	COG1682	transport, permease protein
SMN_2538	COG1088	dTDP-glucose 4,6-dehydratase activity
SMN_2541	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SMN_2542	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMN_2546	COG4191	Histidine kinase
SMN_2547	COG0745	RESPONSE REGULATOR receiver
SMN_2548	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SMN_2551	COG0390	transport system, permease component
SMN_2552	COG0439	Biotin carboxylase
SMN_2555	COG0306	phosphate transporter
SMN_2556	COG0513	Belongs to the DEAD box helicase family
SMN_2557	COG1671	Belongs to the UPF0178 family
SMN_2559	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMN_2561	COG0573	inorganic phosphate transmembrane transporter activity
SMN_2562	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SMN_2563	COG0840	transmembrane signaling receptor activity
SMN_2563	COG3290	protein histidine kinase activity
SMN_2564	COG3384	dioxygenase
SMN_2565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMN_2566	COG0471	metal ion transport
SMN_2567	COG0840	transmembrane signaling receptor activity
SMN_2572	COG0745	RESPONSE REGULATOR receiver
SMN_2574	COG1607	acyl-coa hydrolase
SMN_2580	COG1733	regulation of RNA biosynthetic process
SMN_2581	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMN_2583	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SMN_2584	COG0602	queuosine metabolic process
SMN_2589	COG1702	phosphate starvation-inducible protein PhoH
SMN_2591	COG2814	Major facilitator Superfamily
SMN_2592	COG0477	Major facilitator Superfamily
SMN_2594	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMN_2598	COG3787	Belongs to the UPF0306 family
SMN_2599	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SMN_2605	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMN_2605	COG1013	pyruvate-flavodoxin oxidoreductase activity
SMN_2605	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMN_2605	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SMN_2606	COG0546	phosphoglycolate phosphatase activity
SMN_2611	COG2818	Glycosylase
SMN_2613	COG1979	alcohol dehydrogenase
SMN_2615	COG0038	chloride channel
SMN_2616	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SMN_2619	COG4680	protein conserved in bacteria
SMN_2621	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMN_2630	COG3278	Belongs to the heme-copper respiratory oxidase family
SMN_2631	COG0745	RESPONSE REGULATOR receiver
SMN_2634	COG0505	Belongs to the CarA family
SMN_2638	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMN_2639	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SMN_2640	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SMN_2642	COG0840	transmembrane signaling receptor activity
SMN_2643	COG0546	phosphoglycolate phosphatase activity
SMN_2644	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMN_2647	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMN_2648	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SMN_2649	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMN_2652	COG0203	ribosomal protein L17
SMN_2654	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMN_2655	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMN_2656	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMN_2658	COG0024	Methionine aminopeptidase
SMN_2659	COG0201	protein transport
SMN_2660	COG0200	Binds to the 23S rRNA
SMN_2663	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMN_2664	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMN_2666	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMN_2667	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMN_2668	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMN_2669	COG0255	Belongs to the universal ribosomal protein uL29 family
SMN_2670	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMN_2671	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMN_2673	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMN_2674	COG0089	rRNA binding
SMN_2675	COG0088	Forms part of the polypeptide exit tunnel
SMN_2676	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMN_2677	COG0051	transcription antitermination factor activity, RNA binding
SMN_2680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMN_2681	COG0672	)-iron permease
SMN_2686	COG1136	(ABC) transporter
SMN_2686	COG0577	efflux transmembrane transporter activity
SMN_2691	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SMN_2692	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMN_2693	COG0571	ribonuclease III activity
SMN_2694	COG0328	RNA-DNA hybrid ribonuclease activity
SMN_2696	COG0358	DNA primase activity
SMN_2697	COG0137	argininosuccinate synthase activity
SMN_2698	COG2201	protein-glutamate methylesterase activity
SMN_2702	COG0840	transmembrane signaling receptor activity
SMN_2703	COG2201	protein-glutamate methylesterase activity
SMN_2704	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SMN_2705	COG2205	protein histidine kinase activity
SMN_2706	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SMN_2708	COG0840	transmembrane signaling receptor activity
SMN_2709	COG0835	chemotaxis
SMN_2711	COG0484	heat shock protein binding
SMN_2732	COG4206	TonB-dependent receptor
SMN_2736	COG1918	ferrous iron import across plasma membrane
SMN_2736	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SMN_2737	COG1918	ferrous iron import across plasma membrane
SMN_2739	COG4773	Receptor
SMN_2744	COG0848	biopolymer transport protein
SMN_2745	COG0811	peptide transport
SMN_2749	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SMN_2752	COG1011	Hydrolase
SMN_2753	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
SMN_2754	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
SMN_2758	COG1280	lysine exporter protein (LysE YggA)
SMN_2759	COG1090	epimerase
SMN_2767	COG2962	Rard protein
SMN_2769	COG0642	Histidine kinase
SMN_2770	COG2194	sulfuric ester hydrolase activity
SMN_2772	COG2200	EAL domain
SMN_2773	COG4191	Histidine kinase
SMN_2774	COG4191	Histidine kinase
SMN_2776	COG0840	transmembrane signaling receptor activity
SMN_2779	COG1342	Belongs to the UPF0251 family
SMN_2780	COG1968	undecaprenyl-diphosphatase activity
SMN_2781	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SMN_2786	COG1027	Aspartate ammonia-lyase
SMN_2787	COG1027	Aspartate ammonia-lyase
SMN_2788	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SMN_2789	COG0252	asparaginase activity
SMN_2790	COG3852	Histidine kinase
SMN_2791	COG0745	RESPONSE REGULATOR receiver
SMN_2795	COG3177	Filamentation induced by cAMP protein fic
SMN_2797	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SMN_2807	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMN_2807	COG1333	cytochrome c biogenesis protein
SMN_2808	COG3301	Polysulphide reductase, NrfD
SMN_2809	COG0437	4 iron, 4 sulfur cluster binding
SMN_2810	COG0545	Peptidyl-prolyl cis-trans isomerase
SMN_2811	COG0484	heat shock protein binding
SMN_2812	COG3852	Histidine kinase
SMN_2813	COG0840	transmembrane signaling receptor activity
SMN_2818	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMN_2819	COG0586	Pfam SNARE associated Golgi protein
SMN_2823	COG0848	biopolymer transport protein
SMN_2824	COG0811	peptide transport
SMN_2825	COG0709	Synthesizes selenophosphate from selenide and ATP
SMN_2826	COG0425	Belongs to the sulfur carrier protein TusA family
SMN_2829	COG3447	MASE1 domain protein
SMN_2829	COG5002	protein histidine kinase activity
SMN_2829	COG5001	Diguanylate cyclase
SMN_2833	COG4662	Binding-protein-dependent transport system inner membrane component
SMN_2834	COG2998	abc-type tungstate transport system, permease component
SMN_2835	COG1177	transmembrane transport
SMN_2836	COG3842	ATPase activity
SMN_2837	COG0725	ABC transporter, periplasmic molybdate-binding protein
SMN_2839	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SMN_2841	COG0437	4 iron, 4 sulfur cluster binding
SMN_2850	COG0848	biopolymer transport protein
SMN_2851	COG0811	peptide transport
SMN_2857	COG0500	methyltransferase
SMN_2859	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMN_2864	COG4977	sequence-specific DNA binding
SMN_2864	COG1917	Cupin 2, conserved barrel domain protein
SMN_2866	COG0437	4 iron, 4 sulfur cluster binding
SMN_2872	COG4191	Histidine kinase
SMN_2873	COG0745	RESPONSE REGULATOR receiver
SMN_2874	COG1921	L-seryl-tRNASec selenium transferase activity
SMN_2879	COG1741	Belongs to the pirin family
SMN_2886	COG0745	RESPONSE REGULATOR receiver
SMN_2887	COG5000	phosphorelay sensor kinase activity
SMN_2887	COG5002	protein histidine kinase activity
SMN_2894	COG2986	histidine ammonia-lyase
SMN_2895	COG1028	Short-chain dehydrogenase reductase Sdr
SMN_2899	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMN_2902	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMN_2903	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMN_2904	COG0513	Belongs to the DEAD box helicase family
SMN_2910	COG1305	Transglutaminase-like
SMN_2916	COG0439	Biotin carboxylase
SMN_2918	COG3665	Urea carboxylase-associated protein
SMN_2919	COG3842	ATPase activity
SMN_2920	COG2011	ABC-type metal ion transport system permease component
SMN_2922	COG2205	protein histidine kinase activity
SMN_2922	COG2202	Pas domain
SMN_2925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMN_2926	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SMN_2928	COG1840	ABC-type Fe3 transport system, periplasmic component
SMN_2929	COG3842	ATPase activity
SMN_2931	COG0745	RESPONSE REGULATOR receiver
SMN_2932	COG2205	protein histidine kinase activity
SMN_2933	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SMN_2934	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SMN_2935	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SMN_2936	COG0523	cobalamin synthesis protein
SMN_2939	COG4191	Histidine kinase
SMN_2941	COG0700	Nucleoside recognition
SMN_2942	COG3366	ferrous iron transmembrane transporter activity
SMN_2943	COG1473	amidohydrolase
SMN_2946	COG0300	oxidoreductase activity
SMN_2949	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SMN_2950	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SMN_2952	COG2814	Major facilitator Superfamily
SMN_2953	COG1238	metal cluster binding
SMN_2957	COG0303	'Molybdopterin
SMN_2958	COG0314	molybdopterin synthase activity
SMN_2961	COG1104	cysteine desulfurase activity
SMN_2962	COG1157	protein secretion by the type III secretion system
SMN_2963	COG0302	gtp cyclohydrolase
SMN_2964	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMN_2965	COG0740	serine-type endopeptidase activity
SMN_2969	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SMN_2969	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SMN_2970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SMN_2971	COG2022	thiamine diphosphate biosynthetic process
SMN_2981	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SMN_2982	COG3976	FMN-binding domain protein
SMN_2982	COG0431	NADPH-dependent FMN reductase
SMN_2982	COG1053	succinate dehydrogenase
SMN_2983	COG0644	oxidoreductase
SMN_2994	COG0437	4 iron, 4 sulfur cluster binding
SMN_2995	COG0243	molybdopterin cofactor binding
SMN_3000	COG3850	Histidine kinase
SMN_3000	COG5002	protein histidine kinase activity
SMN_3001	COG1012	belongs to the aldehyde dehydrogenase family
SMN_3004	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMN_3007	COG2183	response to ionizing radiation
SMN_3013	COG0840	transmembrane signaling receptor activity
SMN_3014	COG0778	Nitroreductase
SMN_3021	COG0577	efflux transmembrane transporter activity
SMN_3022	COG1136	(ABC) transporter
SMN_3026	COG1472	Belongs to the glycosyl hydrolase 3 family
SMN_3027	COG1301	dicarboxylic acid transport
SMN_3028	COG0475	glutathione-regulated potassium exporter activity
SMN_3029	COG1280	lysine exporter protein (LysE YggA)
SMN_3032	COG0454	-acetyltransferase
SMN_3033	COG0431	NADPH-dependent FMN reductase
SMN_3037	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMN_3038	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMN_3042	COG0745	RESPONSE REGULATOR receiver
SMN_3044	COG3842	ATPase activity
SMN_3046	COG1840	ABC-type Fe3 transport system, periplasmic component
SMN_3049	COG0175	sulfate reduction
SMN_3050	COG0175	sulfate reduction
SMN_3051	COG2895	sulfate adenylyltransferase (ATP) activity
SMN_3053	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SMN_3055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMN_3057	COG2873	o-acetylhomoserine
SMN_3059	COG0482	sulfurtransferase activity
SMN_3064	COG5002	protein histidine kinase activity
SMN_3066	COG2199	diguanylate cyclase activity
SMN_3066	COG2203	Gaf domain
SMN_3069	COG0745	RESPONSE REGULATOR receiver
SMN_3077	COG4232	protein-disulfide reductase activity
SMN_3078	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMN_3079	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SMN_3080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMN_3082	COG0243	molybdopterin cofactor binding
SMN_3085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMN_3087	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SMN_3094	COG0577	efflux transmembrane transporter activity
SMN_3094	COG1136	(ABC) transporter
SMN_3103	COG1136	(ABC) transporter
SMN_3104	COG2204	response regulator
SMN_3105	COG2205	protein histidine kinase activity
SMN_3105	COG0745	RESPONSE REGULATOR receiver
SMN_3105	COG4191	Histidine kinase
SMN_3108	COG0243	molybdopterin cofactor binding
SMN_3110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SMN_3111	COG0840	transmembrane signaling receptor activity
SMN_3113	COG0861	Integral membrane protein TerC family
SMN_3114	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMN_3115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMN_3116	COG4303	Ethanolamine ammonia lyase large subunit
SMN_3117	COG4302	ethanolamine ammonia-lyase activity
SMN_3118	COG0531	amino acid
SMN_3119	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMN_3120	COG0281	malic enzyme
SMN_3120	COG0280	phosphate acetyltransferase
SMN_3123	COG0439	Biotin carboxylase
SMN_3124	COG0511	ligase activity, forming carbon-carbon bonds
SMN_3125	COG0717	Belongs to the dCTP deaminase family
SMN_3128	COG3041	Addiction module toxin RelE StbE family
SMN_3130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMN_3133	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMN_3134	COG1086	Polysaccharide biosynthesis protein
SMN_3135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMN_3136	COG1083	cytidylyl-transferase
SMN_3138	COG2089	acid synthase
SMN_3142	COG0318	PFAM AMP-dependent synthetase and ligase
SMN_3143	COG1216	Glycosyl transferase, family 2
SMN_3144	COG0562	UDP-galactopyranose mutase
SMN_3146	COG1216	Glycosyl transferase, family 2
SMN_3147	COG1216	Glycosyl transferase, family 2
SMN_3148	COG0110	maltose O-acetyltransferase activity
SMN_3150	COG2226	methyltransferase
SMN_3156	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMN_3157	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMN_3158	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SMN_3159	COG0372	Belongs to the citrate synthase family
SMN_3162	COG0148	phosphopyruvate hydratase activity
SMN_3163	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SMN_3164	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMN_3165	COG1987	bacterial-type flagellum assembly
SMN_3166	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMN_3167	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMN_3174	COG1408	metallophosphoesterase
SMN_3175	COG1115	amino acid carrier protein
SMN_3176	COG2233	PERMEase
SMN_3177	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SMN_3178	COG0575	Belongs to the CDS family
SMN_3181	COG1929	Belongs to the glycerate kinase type-1 family
SMN_3182	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMN_3187	COG0450	alkyl hydroperoxide reductase
SMN_3188	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMN_3190	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMN_3191	COG0746	molybdenum cofactor guanylyltransferase activity
SMN_3198	COG0724	RNA recognition motif
SMN_3199	COG0315	cyclic pyranopterin monophosphate synthase activity
SMN_3202	COG3328	transposase activity
SMN_3209	COG3328	transposase activity
SMN_3216	COG1140	nitrate reductase beta subunit
SMN_3217	COG0243	molybdopterin cofactor binding
SMN_3218	COG2897	thiosulfate sulfurtransferase activity
SMN_3220	COG0489	protein tyrosine kinase activity
SMN_3234	COG0670	Belongs to the BI1 family
SMN_3244	COG0437	4 iron, 4 sulfur cluster binding
SMN_3245	COG0243	molybdopterin cofactor binding
SMN_3246	COG4106	trans-aconitate 2-methyltransferase activity
SMN_3248	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMN_3249	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SMN_3251	COG0233	cytoplasmic translational termination
SMN_3252	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMN_3257	COG1704	LemA family
SMN_3261	COG1749	Flagellar hook protein flgE
SMN_3262	COG1749	Flagellar hook protein flgE
SMN_3263	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SMN_3264	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group