locus-tag	class	description
YH65_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
YH65_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
YH65_00015	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
YH65_00020	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
YH65_00030	ENOG4107RIU	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity)
YH65_00045	ENOG4105EUJ	GTP cyclohydrolase i
YH65_00050	ENOG4105CEN	a g-specific adenine glycosylase
YH65_00055	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
YH65_00060	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
YH65_00065	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
YH65_00070	ENOG4105C0P	Mg chelatase subunit ChlI
YH65_00075	ENOG4105HMI	Membrane
YH65_00080	ENOG4105DUM	transcriptional regulator, lysR family
YH65_00085	ENOG41080AZ	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
YH65_00090	ENOG4105D8G	Major Facilitator superfamily
YH65_00125	ENOG4108VAU	general secretion pathway protein G
YH65_00155	ENOG4105GVR	general secretion pathway protein D
YH65_00160	ENOG4107QHF	type ii secretion system protein e
YH65_00175	ENOG4105BZU	Histidine kinase
YH65_00180	ENOG4107VCP	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
YH65_00185	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
YH65_00190	ENOG4105NU9	Preprotein translocase subunit SecG
YH65_00200	ENOG4105HFZ	Membrane
YH65_00225	ENOG41083MR	nifu domain-containing protein
YH65_00235	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
YH65_00240	ENOG4105FQT	
YH65_00265	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
YH65_00270	ENOG41084FT	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
YH65_00290	ENOG4105CJ3	phosphate transporter
YH65_00295	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
YH65_00300	ENOG4105C9U	ATP-dependent DNA helicase RecQ
YH65_00305	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
YH65_00315	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
YH65_00320	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
YH65_00325	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
YH65_00335	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
YH65_00340	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
YH65_00355	ENOG4105BZU	Histidine kinase
YH65_00380	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
YH65_00395	ENOG4105CEY	Amp-dependent synthetase and ligase
YH65_00400	ENOG4105CE4	GlcNAc 6-P deacetylase
YH65_00405	ENOG4105C5Y	PTS System
YH65_00410	ENOG4105CI1	PTS System
YH65_00415	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
YH65_00425	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
YH65_00440	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
YH65_00445	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
YH65_00450	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
YH65_00455	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
YH65_00480	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
YH65_00485	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
YH65_00495	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
YH65_00500	ENOG4105D65	subunit l
YH65_00505	ENOG4105C8S	subunit m
YH65_00510	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
YH65_00515	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
YH65_00520	ENOG4108VTU	Cdp-alcohol phosphatidyltransferase
YH65_00525	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
YH65_00560	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
YH65_00565	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
YH65_00570	ENOG4105C75	arginyL-tRNA synthetase
YH65_00585	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
YH65_00590	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
YH65_00595	ENOG4105BZA	Phosphoglycerate kinase
YH65_00600	ENOG4105CP7	Triose-phosphate isomerase
YH65_00605	ENOG4105CHV	Transcription elongation factor NusA
YH65_00615	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
YH65_00620	ENOG4105KB8	(LipO)protein
YH65_00625	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
YH65_00635	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
YH65_00640	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
YH65_00660	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
YH65_00665	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
YH65_00675	ENOG4105CHR	reductase
YH65_00685	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
YH65_00690	ENOG4105ES5	Histidine kinase
YH65_00710	ENOG4105CY0	Metallo-Beta-Lactamase
YH65_00715	ENOG410822N	TonB family
YH65_00725	ENOG4105EQJ	Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity)
YH65_00735	ENOG4105DH4	Periplasmic copper-binding protein
YH65_00760	ENOG4108JJB	ABC transporter
YH65_00780	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
YH65_00805	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
YH65_00820	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
YH65_00825	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
YH65_00830	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
YH65_00835	ENOG4107T5V	SNARE associated Golgi
YH65_00840	ENOG4105C1J	atp-dependent rna helicase
YH65_00850	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
YH65_00855	ENOG4107SVH	Potassium channel protein
YH65_00860	ENOG4105VB9	50S ribosomal protein l28
YH65_00865	ENOG4105DJV	ribulose-phosphate 3-epimerase
YH65_00870	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
YH65_00875	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
YH65_00885	ENOG4108Z0R	Transferase
YH65_00895	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
YH65_00905	ENOG41090SZ	ABC-2 type transporter
YH65_00945	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
YH65_00965	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
YH65_00970	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
YH65_00975	ENOG4105DHP	deoxycytidine triphosphate deaminase
YH65_00980	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
YH65_00995	ENOG4105CB5	ATP-dependent DNA helicase recG
YH65_01000	ENOG4105EY8	ABC transporter
YH65_01045	ENOG4108RYC	glycosyltransferase
YH65_01055	ENOG4107ZAZ	Oligosaccharyl transferase, STT3 subunit
YH65_01070	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
YH65_01085	ENOG4108ZEX	molybdopterin converting factor, subunit 2
YH65_01090	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
YH65_01105	ENOG4105C7Z	Conserved Protein
YH65_01120	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
YH65_01130	ENOG4107RYS	Autoinducer-2 (AI-2) kinase
YH65_01145	ENOG410802Z	Protein of unknown function (DUF328)
YH65_01170	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
YH65_01175	ENOG41084ED	50S ribosomal protein L33
YH65_01190	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
YH65_01195	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
YH65_01200	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
YH65_01205	ENOG4108VZM	50s ribosomal protein L10
YH65_01210	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
YH65_01215	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
YH65_01220	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
YH65_01225	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
YH65_01230	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
YH65_01235	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
YH65_01250	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
YH65_01255	ENOG4108KMM	Diguanylate cyclase
YH65_01260	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
YH65_01265	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
YH65_01275	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
YH65_01280	ENOG4105KNE	Phosphatidate cytidylyltransferase
YH65_01285	ENOG4105F23	Fibronectin-binding protein
YH65_01290	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
YH65_01315	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
YH65_01325	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
YH65_01330	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
YH65_01335	ENOG41082DJ	30S ribosomal protein S21
YH65_01340	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
YH65_01350	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
YH65_01365	ENOG4105UQX	Mate efflux family protein
YH65_01375	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
YH65_01395	ENOG4105CV1	Transketolase (EC 2.2.1.1)
YH65_01400	ENOG4107RDB	Major Facilitator
YH65_01405	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
YH65_01450	ENOG4105C11	sulfate adenylyltransferase), subunit 2
YH65_01455	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
YH65_01460	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
YH65_01465	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
YH65_01470	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
YH65_01475	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
YH65_01480	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
YH65_01485	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
YH65_01490	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
YH65_01500	ENOG4105E12	capsule polysaccharide
YH65_01505	ENOG41084CK	capsule polysaccharide
YH65_01555	ENOG4108VAU	general secretion pathway protein G
YH65_01560	ENOG4105C25	Primosomal protein n'
YH65_01565	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
YH65_01570	ENOG4105CDU	Replicative dna helicase
YH65_01580	ENOG4107S2Z	UPF0761 membrane protein
YH65_01585	ENOG4105CQB	FAD linked oxidase domain protein
YH65_01595	ENOG4105E4C	Lytic transglycosylase catalytic
YH65_01615	ENOG4105DWY	Agmatine deiminase
YH65_01620	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
YH65_01645	ENOG4105CMM	transposase
YH65_01665	ENOG4105F4R	Transcriptional regulator mode
YH65_01670	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
YH65_01695	ENOG4105CIZ	coA-substrate-specific enzyme activase
YH65_01700	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
YH65_01710	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
YH65_01715	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
YH65_01720	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
YH65_01725	ENOG4105F4G	Membrane
YH65_01730	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
YH65_01735	ENOG4105BZU	Histidine kinase
YH65_01740	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
YH65_01745	ENOG4105D4P	Coproporphyrinogen iii oxidase
YH65_01750	ENOG4105DBV	ornithine carbamoyltransferase
YH65_01755	ENOG4105D52	delta-aminolevulinic acid dehydratase
YH65_01760	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
YH65_01780	ENOG4105BZU	Histidine kinase
YH65_01790	ENOG4105WH1	Two component transcriptional regulator luxr family
YH65_01800	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
YH65_01830	ENOG4105CXT	aspartate transcarbamylase
YH65_01835	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
YH65_01840	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
YH65_01850	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
YH65_01855	ENOG4107V25	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
YH65_01860	ENOG4105CZX	twitching motility protein
YH65_01865	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
YH65_01870	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
YH65_01880	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
YH65_01885	ENOG4105CQC	Prephenate dehydratase
YH65_01890	ENOG4105CIH	Imidazole acetol-phosphate transaminase
YH65_01900	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
YH65_01905	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
YH65_01910	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
YH65_01915	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
YH65_01925	ENOG4105YQ2	50s ribosomal protein l32
YH65_01930	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
YH65_01935	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
YH65_01940	ENOG4105D48	metallophosphoesterase
YH65_01945	ENOG4107QMP	dna polymerase iii subunits gamma and tau
YH65_01965	ENOG4105C8T	Leucyl-tRNA synthetase
YH65_01975	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
YH65_01980	ENOG4108JA2	transcriptioN-repair coupling factor
YH65_02005	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
YH65_02055	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YH65_02060	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
YH65_02065	ENOG4105C6K	Malic enzyme
YH65_02080	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
YH65_02095	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
YH65_02100	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
YH65_02105	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
YH65_02110	ENOG4105SFS	phosphoesterase RecJ domain protein
YH65_02120	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
YH65_02130	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
YH65_02140	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
YH65_02145	ENOG4105MGB	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
YH65_02150	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
YH65_02155	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
YH65_02160	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
YH65_02165	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
YH65_02170	ENOG4105BZU	Histidine kinase
YH65_02175	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
YH65_02180	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
YH65_02195	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
YH65_02200	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
YH65_02205	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
YH65_02210	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
YH65_02215	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
YH65_02220	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
YH65_02225	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
YH65_02230	ENOG4105D16	lipopolysaccharide heptosyltransferase i
YH65_02250	ENOG4106WTF	Glycosyl transferase, family 2
YH65_02260	ENOG4105DKP	glycosyl transferase, family 9
YH65_02265	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
YH65_02270	ENOG4105BZ1	(ABC) transporter
YH65_02275	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
YH65_02290	ENOG4105D3Q	Sugar transferase
YH65_02295	ENOG4106CD9	glycosyl transferase group 1
YH65_02300	ENOG4108Z90	colanic acid biosynthesis acetyltransferase wcaF
YH65_02305	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
YH65_02310	ENOG4105ECJ	Glycosyl Transferase
YH65_02320	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
YH65_02355	ENOG4105EY8	ABC transporter
YH65_02375	ENOG4105C30	Nad-dependent epimerase dehydratase
YH65_02380	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
YH65_02390	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
YH65_02395	ENOG4107QP8	phosphohexose isomerase
YH65_02400	ENOG4107QKV	phosphomannomutase
YH65_02405	ENOG4105CMR	udp-glucose 4-epimerase
YH65_02420	ENOG4105C59	p-type ATPase
YH65_02430	ENOG4105D82	Glutamate dehydrogenase
YH65_02435	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
YH65_02440	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
YH65_02445	ENOG4105C31	Tryptophanyl-tRNA synthetase
YH65_02450	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
YH65_02455	ENOG4105D64	Mechanosensitive ion channel
YH65_02470	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
YH65_02475	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
YH65_02480	ENOG4105M7K	Involved in the transcription termination process (By similarity)
YH65_02485	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
YH65_02495	ENOG4105CB5	ATP-dependent DNA helicase recG
YH65_02500	ENOG4105MS2	ribosomal subunit Interface protein
YH65_02535	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
YH65_02545	ENOG4105BZU	Histidine kinase
YH65_02555	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
YH65_02560	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
YH65_02570	ENOG4108IYU	L-aspartate oxidase
YH65_02580	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
YH65_02605	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
YH65_02630	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
YH65_02635	ENOG41076HS	cation diffusion facilitator family transporter
YH65_02645	ENOG4105C12	Phosphoribosylglycinamide synthetase
YH65_02650	ENOG4105VQU	rdd domain containing protein
YH65_02655	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
YH65_02660	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
YH65_02670	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
YH65_02675	ENOG41084IH	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
YH65_02700	ENOG4108RAC	Rubrerythrin
YH65_02705	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
YH65_02715	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
YH65_02720	ENOG4108KA0	Inherit from COG: Phosphoesterase, DHHA1
YH65_02725	ENOG410847I	Transcriptional regulator, BadM Rrf2 family
YH65_02730	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
YH65_02735	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
YH65_02740	ENOG4105CFG	Acts as a chaperone (By similarity)
YH65_02765	ENOG4105BZU	Histidine kinase
YH65_02770	ENOG41080XP	Cbs domain
YH65_02810	ENOG4105C7Z	Conserved Protein
YH65_02815	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
YH65_02820	ENOG4105QNR	S1 RNA binding domain protein
YH65_02835	ENOG4108YXA	Membrane
YH65_02870	ENOG4105BZU	Histidine kinase
YH65_02890	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
YH65_02900	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
YH65_02905	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
YH65_02910	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
YH65_02915	ENOG4105K4P	CoA-binding domain protein
YH65_02925	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
YH65_02930	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
YH65_02935	ENOG4105C7B	Threonine dehydratase
YH65_02950	ENOG4105BZU	Histidine kinase
YH65_02955	ENOG4105C7K	acetolactate synthase
YH65_02960	ENOG4108ZP8	Acetolactate synthase small subunit
YH65_02965	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
YH65_02975	ENOG4105BZU	Histidine kinase
YH65_02985	ENOG4105C5H	ABC transporter
YH65_02990	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
YH65_02995	ENOG41066A3	ATP guanido phosphotransferase
YH65_03010	ENOG4105CIN	aminoacyl-histidine dipeptidase
YH65_03015	ENOG4105CSR	polyphosphate kinase 2
YH65_03020	ENOG4105CSM	endonuclease III
YH65_03025	ENOG4105EIN	peptidylprolyl cis-trans isomerase
YH65_03040	ENOG4105D2N	Aldolase
YH65_03050	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
YH65_03100	ENOG4105CEV	competence damage-inducible protein
YH65_03105	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
YH65_03110	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
YH65_03115	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
YH65_03125	ENOG4105DWV	Homoserine O-trans-acetylase
YH65_03140	ENOG4105D06	uba thif-type nad fad binding protein
YH65_03155	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
YH65_03160	ENOG4105K46	50S ribosomal protein l27
YH65_03170	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
YH65_03175	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
YH65_03180	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
YH65_03190	ENOG4107QJE	Chromosome Partitioning Protein
YH65_03195	ENOG4105FA0	parb-like partition protein
YH65_03205	ENOG4105YF2	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
YH65_03210	ENOG4105PQH	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
YH65_03215	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
YH65_03220	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
YH65_03225	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
YH65_03230	ENOG41082MC	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
YH65_03235	ENOG4105E02	MotA TolQ exbB proton channel
YH65_03240	ENOG4105M8F	Biopolymer transport protein exbD tolR
YH65_03250	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
YH65_03255	ENOG4105NBF	ammecr1 domain protein
YH65_03260	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
YH65_03280	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
YH65_03285	ENOG4108YZY	peptidylprolyl cis-trans isomerase
YH65_03295	ENOG4105VCQ	rubredoxin
YH65_03300	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
YH65_03305	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
YH65_03310	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
YH65_03330	ENOG4105C34	Pseudouridine synthase
YH65_03340	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
YH65_03345	ENOG4105CAK	Cell division ATP-binding protein ftsE
YH65_03360	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
YH65_03365	ENOG410692R	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
YH65_03370	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
YH65_03375	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
YH65_03385	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
YH65_03390	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
YH65_03410	ENOG4105BZU	Histidine kinase
YH65_03430	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
YH65_03435	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
YH65_03440	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
YH65_03445	ENOG4105CIY	formyltetrahydrofolate deformylase
YH65_03450	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
YH65_03460	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
YH65_03485	ENOG4105DK0	Indole-3-glycerol phosphate synthase
YH65_03505	ENOG4105E0X	reductase
YH65_03520	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
YH65_03525	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
YH65_03535	ENOG4105CDH	Citrulline--aspartate ligase
YH65_03545	ENOG4105DGW	oligopeptidase A
YH65_03550	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
YH65_03555	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
YH65_03560	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
YH65_03565	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
YH65_03585	ENOG4105E4G	Type IV pilus
YH65_03600	ENOG4107QHF	type ii secretion system protein e
YH65_03610	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
YH65_03615	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
YH65_03625	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
YH65_03630	ENOG4108YZA	Nitrogen regulatory protein pii
YH65_03640	ENOG4108YZA	Nitrogen regulatory protein pii
YH65_03645	ENOG4105BZU	Histidine kinase
YH65_03675	ENOG4105ED9	Protein of unknown function (DUF455)
YH65_03680	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
YH65_03685	ENOG4105CAS	nag kinase
YH65_03690	ENOG4105CA0	peroxidase
YH65_03705	ENOG4107QID	Threonine synthase
YH65_03715	ENOG4105CDY	transcriptional regulatory protein
YH65_03720	ENOG4105CNG	UPF0061 protein
YH65_03730	ENOG4105T1H	UPF0763 protein
YH65_03735	ENOG4105XXY	Thioredoxin
YH65_03740	ENOG4105M15	transport protein ExbD
YH65_03745	ENOG4105M8K	biopolymer transport protein
YH65_03755	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
YH65_03765	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
YH65_03790	ENOG41082XB	radical SAM domain protein
YH65_03830	ENOG41080V7	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
YH65_03835	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
YH65_03840	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
YH65_03860	ENOG4108621	K01512 acylphosphatase EC 3.6.1.7
YH65_03870	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
YH65_03875	ENOG4105K63	Thioredoxin
YH65_03880	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
YH65_03885	ENOG4105BZU	Histidine kinase
YH65_03905	ENOG41067HZ	cytochrome C, class I
YH65_03915	ENOG4108IJF	Heavy metal efflux pump, CzcA
YH65_03945	ENOG4105CSR	polyphosphate kinase 2
YH65_03960	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
YH65_03975	ENOG4105BZU	Histidine kinase
YH65_03980	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
YH65_03985	ENOG4105DC7	peptidase M24
YH65_03990	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
YH65_03995	ENOG4105FZW	flagellar biosynthesis regulator FlhF
YH65_04005	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
YH65_04015	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
YH65_04020	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
YH65_04030	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
YH65_04075	ENOG4105CNU	cell division protein FtsK
YH65_04080	ENOG4107QIJ	Aconitate hydratase 2
YH65_04090	ENOG4107YD3	Thioesterase
YH65_04185	ENOG4105BZS	acriflavin resistance protein
YH65_04190	ENOG4105BZS	acriflavin resistance protein
YH65_04200	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
YH65_04205	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
YH65_04210	ENOG4105C9M	aspartyl-trna synthetase
YH65_04240	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
YH65_04270	ENOG4108XIB	electron transport protein ysaA
YH65_04275	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
YH65_04290	ENOG4105D9P	serine threonine protein kinase
YH65_04310	ENOG4105D60	lipoprotein releasing system transmembrane protein
YH65_04315	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
YH65_04325	ENOG4105CGY	Dna recombination protein
YH65_04345	ENOG4105C5H	ABC transporter
YH65_04350	ENOG4107XWI	flavin reductase domain protein, FMN-binding
YH65_04355	ENOG4105HHA	aminodeoxychorismate lyase
YH65_04360	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
YH65_04370	ENOG4105DJI	Methylaspartate mutase, E subunit
YH65_04385	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
YH65_04405	ENOG4108UK5	Transposase
YH65_04420	ENOG4108UPT	UPF0178 protein
YH65_04435	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
YH65_04440	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
YH65_04450	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
YH65_04470	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
YH65_04480	ENOG4105DFF	Rod shape-determining protein mreb
YH65_04485	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
YH65_04490	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
YH65_04495	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
YH65_04500	ENOG4105WPN	DNA integration recombination invertion protein
YH65_04505	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
YH65_04520	ENOG4107S6Z	Na H antiporter
YH65_04545	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
YH65_04550	ENOG4105K5B	UPF0225 protein
YH65_04620	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
YH65_04625	ENOG4105EHM	Aminoglycoside phosphotransferase
YH65_04630	ENOG4108S0S	Nucleotidyl transferase
YH65_04635	ENOG410667J	hydrolase
YH65_04650	ENOG4105CA0	peroxidase
YH65_04655	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
YH65_04660	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
YH65_04670	ENOG4105F8V	Hydrolase, tatD family
YH65_04675	ENOG4105K6T	rare lipoprotein A
YH65_04680	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
YH65_04685	ENOG410667J	hydrolase
YH65_04700	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
YH65_04715	ENOG4105CJN	penicillin-binding protein
YH65_04740	ENOG4105CMM	transposase
YH65_04765	ENOG4105DIK	(ABC) transporter
YH65_04790	ENOG4107RZZ	dna polymerase iii epsilon subunit
YH65_04795	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
YH65_04805	ENOG4105DJ4	phosphatidylserine decarboxylase
YH65_04815	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
YH65_04830	ENOG4105D29	Helix-turn-helix type 11 domain protein
YH65_04845	ENOG4105WKZ	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
YH65_04850	ENOG4105BZU	Histidine kinase
YH65_04875	ENOG4108YZN	class I peptide chain release factor
YH65_04885	ENOG4105FE9	pseudouridine synthase
YH65_04920	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
YH65_04925	ENOG4105C5I	Dehydrogenase
YH65_04930	ENOG4105SCY	DNAK suppressor
YH65_04940	ENOG41061AI	Protein of unknown function (DUF2905)
YH65_04950	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
YH65_04965	ENOG41088CC	tellurite resistance protein tehB
YH65_04970	ENOG4105CGK	Exodeoxyribonuclease III
YH65_04990	ENOG4105C3G	gtp-binding protein
YH65_05005	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
YH65_05015	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
YH65_05030	ENOG4105C3F	Signal peptidase i
YH65_05035	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
YH65_05050	ENOG4108YZG	isomerase
YH65_05055	ENOG4108Z4T	Peptidase M50
YH65_05060	ENOG4105C3F	Signal peptidase i
YH65_05065	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
YH65_05080	ENOG4105VEQ	Cold shock protein
YH65_05100	ENOG4108UT2	hemolysin iii
YH65_05105	ENOG4108DWA	Nad synthetase
YH65_05110	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
YH65_05115	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
YH65_05130	ENOG4105CH5	extracellular solute-binding protein, family 7
YH65_05155	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
YH65_05165	ENOG41082IR	Excinuclease ABC C subunit domain protein
YH65_05170	ENOG4108IQE	Amp-dependent synthetase and ligase
YH65_05180	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
YH65_05185	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
YH65_05200	ENOG4108VIA	integral membrane protein
YH65_05205	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
YH65_05210	ENOG4105CX6	glutaminyL-tRNA synthetase
YH65_05235	ENOG4105DCG	PHP domain protein
YH65_05240	ENOG4105VG1	fes assembly suf system protein
YH65_05245	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
YH65_05250	ENOG4105JRK	feS assembly protein SufD
YH65_05255	ENOG4105C3K	feS assembly ATPase SufC
YH65_05265	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
YH65_05280	ENOG4105BZU	Histidine kinase
YH65_05290	ENOG4105BZU	Histidine kinase
YH65_05300	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
YH65_05315	ENOG4105CTQ	phosphohexokinase
YH65_05360	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
YH65_05365	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
YH65_05370	ENOG4105C8V	SAICAR synthetase
YH65_05375	ENOG4105CN1	protease
YH65_05385	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
YH65_05395	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
YH65_05400	ENOG4105CT5	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity)
YH65_05415	ENOG4108V0P	LemA family
YH65_05435	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
YH65_05445	ENOG4105D49	3-dehydroquinate synthase
YH65_05455	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
YH65_05460	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
YH65_05490	ENOG4105CQR	helicase
YH65_05510	ENOG4107RY6	amino acid
YH65_05530	ENOG4107RY6	amino acid
YH65_05560	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
YH65_05565	ENOG4105C1J	atp-dependent rna helicase
YH65_05570	ENOG4105CZX	twitching motility protein
YH65_05575	ENOG4105CPC	Aldo Keto reductase
YH65_05595	ENOG410841Q	phosphoesterase PA-phosphatase related protein
YH65_05600	ENOG4105E0M	Sulfatase
YH65_05610	ENOG4108IG5	Transcriptional regulator
YH65_05615	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
YH65_05620	ENOG4108R5S	membrane
YH65_05625	ENOG4108TQ9	Histidine kinase
YH65_05640	ENOG4105CBX	hi0933 family
YH65_05650	ENOG4105CHH	sulfate transporter
YH65_05675	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
YH65_05690	ENOG4105E1F	short-chain dehydrogenase reductase
YH65_05720	ENOG4105DTQ	mandelate racemase muconate lactonizing
YH65_05725	ENOG4105BZU	Histidine kinase
YH65_05735	ENOG4106H78	methyltransferase
YH65_05745	ENOG4107Y2X	deaminase
YH65_05750	ENOG4105C4R	Atp-dependent dna helicase
YH65_05765	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
YH65_05770	ENOG41080ZE	Adenylate cyclase
YH65_05775	ENOG4105BZU	Histidine kinase
YH65_05780	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
YH65_05790	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
YH65_05805	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
YH65_05825	ENOG41086B8	CoB-CoM heterodisulfide reductase
YH65_05840	ENOG4105BZU	Histidine kinase
YH65_05855	ENOG4107QN2	dihydrolipoyl dehydrogenase
YH65_05870	ENOG4105EIE	fructose-bisphosphate aldolase
YH65_05875	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
YH65_05880	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
YH65_05890	ENOG4105WMR	Protein CrcB homolog
YH65_05895	ENOG4105KJJ	Uncharacterized ACR, COG1993
YH65_05900	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
YH65_05925	ENOG4105CSR	polyphosphate kinase 2
YH65_05940	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
YH65_05955	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
YH65_05960	ENOG4105CY0	Metallo-Beta-Lactamase
YH65_05975	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
YH65_05995	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
YH65_06000	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
YH65_06010	ENOG4107QN1	sodium solute
YH65_06015	ENOG41062QD	Membrane
YH65_06025	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
YH65_06030	ENOG41080BE	Methyl-accepting chemotaxis sensory transducer
YH65_06045	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
YH65_06085	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
YH65_06100	ENOG4107NA1	Endonuclease Exonuclease phosphatase
YH65_06105	ENOG4105C1J	atp-dependent rna helicase
YH65_06110	ENOG4108JU6	CBS domain protein
YH65_06115	ENOG4105CJW	magnesium transporter
YH65_06125	ENOG4107RSR	Malate quinone oxidoreductase
YH65_06140	ENOG4107QPN	acyl-Coa dehydrogenase
YH65_06195	ENOG4108V1U	phospholipid-binding protein
YH65_06215	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
YH65_06220	ENOG4105CHU	acetyl-coa acetyltransferase
YH65_06235	ENOG4108UXE	Protein tyrosine phosphatase
YH65_06285	ENOG4105E0X	reductase
YH65_06295	ENOG4105BZU	Histidine kinase
YH65_06355	ENOG4105HFZ	Membrane
YH65_06370	ENOG41087NI	Sulfite exporter TauE/SafE
YH65_06390	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
YH65_06445	ENOG4108IG5	Transcriptional regulator
YH65_06475	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
YH65_06480	ENOG4105D9Q	decarboxylase (Beta subunit)
YH65_06485	ENOG4107QSA	Oxaloacetate decarboxylase
YH65_06500	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
YH65_06505	ENOG4105BZ1	(ABC) transporter
YH65_06510	ENOG4105EAC	phosphoserine phosphatase
YH65_06520	ENOG41080RH	Thioredoxin
YH65_06530	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
YH65_06535	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
YH65_06540	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
YH65_06545	ENOG4105CUZ	uba thif-type nad fad binding protein
YH65_06555	ENOG4105CRE	cytochrome C
YH65_06575	ENOG4105C2M	dna polymerase I
YH65_06585	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
YH65_06615	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
YH65_06625	ENOG4105NHS	Transcriptional regulator, TraR DksA family
YH65_06630	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
YH65_06675	ENOG41074H6	response regulator
YH65_06695	ENOG4105DY2	Paraquat-inducible protein b
YH65_06700	ENOG4105F1S	paraquat-inducible protein a
YH65_06715	ENOG4105E2D	ec 3.2.1.52
YH65_06720	ENOG4105EHZ	conserved protein UCP016719
YH65_06725	ENOG4107QUV	Domain protein
YH65_06735	ENOG4105CI0	Citrate lyase
YH65_06740	ENOG4105CVE	Lytic murein transglycosylase
YH65_06745	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
YH65_06750	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
YH65_06760	ENOG4105BZU	Histidine kinase
YH65_06765	ENOG4107QPK	)-transporter
YH65_06770	ENOG4105C8P	)-transporter
YH65_06790	ENOG41086VD	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
YH65_06805	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
YH65_06810	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
YH65_06820	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
YH65_06825	ENOG4108V1U	phospholipid-binding protein
YH65_06845	ENOG4105C4Y	ABC transporter
YH65_06880	ENOG4108RCM	Nitroreductase
YH65_06890	ENOG4105C72	UPF0176 protein
YH65_06895	ENOG4108SVW	integral membrane protein
YH65_06905	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
YH65_06910	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
YH65_06915	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
YH65_06920	ENOG4105CUT	histidyl-tRNA synthetase
YH65_06935	ENOG4105DHJ	ABC, transporter
YH65_06945	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
YH65_06950	ENOG4105D7W	serine acetyltransferase
YH65_06995	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
YH65_07000	ENOG4105CNI	cell division protein FtsW
YH65_07055	ENOG4105C5E	polysaccharide biosynthesis protein
YH65_07060	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
YH65_07075	ENOG4105D3Q	Sugar transferase
YH65_07110	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
YH65_07115	ENOG4105C30	Nad-dependent epimerase dehydratase
YH65_07120	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
YH65_07145	ENOG4105KNI	merR family transcriptional Regulator
YH65_07150	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
YH65_07155	ENOG4105C2N	RNA methyltransferase TrmH family group 3
YH65_07160	ENOG4105DC1	bifunctional purine biosynthesis protein purh
YH65_07165	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
YH65_07185	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
YH65_07195	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
YH65_07200	ENOG41067YR	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
YH65_07205	ENOG4105VG0	50S ribosomal protein l34
YH65_07225	ENOG4105CFU	surface antigen
YH65_07230	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
YH65_07240	ENOG4105EYW	Ion transport protein
YH65_07245	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
YH65_07255	ENOG4107WJT	it plays a direct role in the translocation of protons across the membrane (By similarity)
YH65_07265	ENOG4108IUZ	ABC transporter
YH65_07270	ENOG4105K8N	protein family UPF0079, ATPase
YH65_07275	ENOG4107S1N	anthranilate phosphoribosyltransferase
YH65_07280	ENOG410854I	s4 domain protein
YH65_07290	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
YH65_07295	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
YH65_07305	ENOG4105FDK	ABC transporter
YH65_07310	ENOG4108I9K	permease protein
YH65_07320	ENOG4108K7V	UPF0284 protein
YH65_07330	ENOG4105CIH	Imidazole acetol-phosphate transaminase
YH65_07335	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
YH65_07350	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
YH65_07385	ENOG4107QUV	Domain protein
YH65_07395	ENOG4105CQ7	ATP-dependent helicase
YH65_07410	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
YH65_07420	ENOG4105CBC	glutamate synthase
YH65_07430	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
YH65_07435	ENOG4105N2G	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YH65_07445	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
YH65_07465	ENOG4108ZBE	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity)
YH65_07470	ENOG41083UI	stage II sporulation protein
YH65_07485	ENOG4105C7N	Xanthine uracil vitamin C permease
YH65_07490	ENOG4105CPN	adenine deaminase
YH65_07495	ENOG4105K63	Thioredoxin
YH65_07500	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
YH65_07525	ENOG4105F7V	ErfK ybiS ycfS ynhG family protein
YH65_07530	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
YH65_07535	ENOG4105CBX	hi0933 family
YH65_07545	ENOG4105K4H	Nlp p60 protein
YH65_07555	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
YH65_07565	ENOG4105CJR	Integral membrane protein (MviN
YH65_07570	ENOG4105C8N	cysteinyl-tRNA synthetase
YH65_07580	ENOG4108JBU	Outer membrane protein Omp31
YH65_07600	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
YH65_07610	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
YH65_07615	ENOG4105CAN	Short-chain dehydrogenase reductase Sdr
YH65_07620	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
YH65_07630	ENOG4105CE1	Ferrous iron transport protein b
YH65_07635	ENOG4107K9B	ferrous iron transport protein
YH65_07655	ENOG4105E3B	Multicopper oxidase
YH65_07685	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
YH65_07695	ENOG4107STQ	Multicopper oxidase
YH65_07720	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
YH65_07740	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
YH65_07745	ENOG4105DHQ	Histidine kinase
YH65_07755	ENOG41082YX	Transcriptional regulator, arsr family
YH65_07780	ENOG4105ETX	regulatoR
YH65_07785	ENOG4105BZU	Histidine kinase
YH65_07795	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
YH65_07835	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
YH65_07840	ENOG4105IFJ	Histidine kinase
YH65_07850	ENOG4107TZ2	Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity)
YH65_07860	ENOG4108P3C	
YH65_07865	ENOG4107XSR	periplasmic solute binding protein
YH65_07880	ENOG4105DZP	Membrane-associated zinc metalloprotease
YH65_07885	ENOG4105DFA	alanine racemase domain protein
YH65_07900	ENOG4105D3R	alkyl hydroperoxide reductase
YH65_07905	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
YH65_07915	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
YH65_07930	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
YH65_07935	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
YH65_07940	ENOG4105EAH	synthase
YH65_07955	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
YH65_07975	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
YH65_07985	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
YH65_07990	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
YH65_08000	ENOG4106032	Glutathionylspermidine synthase
YH65_08010	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
YH65_08035	ENOG4105C2Y	STE24 endopeptidase EC 3.4.24.84
YH65_08040	ENOG4105C5H	ABC transporter
YH65_08045	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
YH65_08060	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
YH65_08070	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YH65_08075	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
YH65_08085	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
YH65_08090	ENOG410829W	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
YH65_08110	ENOG4105C8Y	Acetylornithine aminotransferase
YH65_08115	ENOG4105D8D	Type III
YH65_08130	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
YH65_08170	ENOG4108NEV	two component transcriptional regulator, LytTR family
YH65_08215	ENOG4105CGH	5'-nucleotidase
YH65_08245	ENOG4105DQU	oxidoreductase, subunit beta
YH65_08250	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
YH65_08260	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
YH65_08265	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
YH65_08270	ENOG4105C9Q	fumarate hydratase class II
YH65_08285	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
YH65_08290	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
YH65_08295	ENOG4105E9K	Isocitrate dehydrogenase
YH65_08305	ENOG4105C0B	DNA polymerase III (alpha subunit)
YH65_08315	ENOG4107S0N	DJ-1 family
YH65_08320	ENOG4105CAY	ferredoxin--nadp reductase
YH65_08350	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
YH65_08375	ENOG4108JQ1	Dehydrogenase
YH65_08380	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
YH65_08385	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
YH65_08390	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
YH65_08395	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
YH65_08400	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
YH65_08410	ENOG4105CH7	arginosuccinase
YH65_08435	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
YH65_08450	ENOG4105DDQ	anthranilate synthase
YH65_08455	ENOG4105DVY	radical SAM domain protein
YH65_08460	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
YH65_08465	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
YH65_08475	ENOG4107T0D	ABC, transporter
YH65_08485	ENOG4105DP9	ABC transporter
YH65_08495	ENOG4105DWF	phosphomethylpyrimidine kinase
YH65_08500	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
YH65_08505	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
YH65_08520	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
YH65_08525	ENOG4107QYE	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
YH65_08540	ENOG4105D1F	ATP-binding protein
YH65_08545	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
YH65_08550	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
YH65_08560	ENOG4108ZAI	phosphatidylglycerophosphatase a
YH65_08565	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
YH65_08575	ENOG4105C6K	Malic enzyme
YH65_08610	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
YH65_08630	ENOG4105C7Z	Conserved Protein
YH65_08660	ENOG4105C7Z	Conserved Protein
YH65_08690	ENOG4105C7Z	Conserved Protein
YH65_08710	ENOG4105CGH	5'-nucleotidase
YH65_08735	ENOG4105BZU	Histidine kinase
YH65_08740	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
YH65_08755	ENOG4108X4D	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
YH65_08770	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
YH65_08775	ENOG4105C72	UPF0176 protein
YH65_08785	ENOG410855J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
YH65_08790	ENOG4105KUZ	arsenate reductase
YH65_08795	ENOG4105CZX	twitching motility protein
YH65_08810	ENOG4105CRK	lysyL-tRNA synthetase
YH65_08815	ENOG4105CVE	Lytic murein transglycosylase
YH65_08820	ENOG4107RWR	Sodium hydrogen exchanger
YH65_08825	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
YH65_08835	ENOG4107S1Q	Phosphatase
YH65_08870	ENOG4105CRQ	synthase (Component I)
YH65_08875	ENOG4105E2X	shikimate dehydrogenase
YH65_08885	ENOG4105ECM	Sensor protein basS pmrB
YH65_08890	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
YH65_08895	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
YH65_08900	ENOG4105BZU	Histidine kinase
YH65_08905	ENOG4105DTN	riboflavin biosynthesis protein ribF
YH65_08915	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
YH65_08925	ENOG4105EEI	dihydropteroate synthase
YH65_08940	ENOG4105CFH	Aspartokinase
YH65_08945	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
YH65_08950	ENOG4105CSA	Coproporphyrinogen iii oxidase
YH65_08955	ENOG41084AD	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
YH65_08960	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
YH65_08965	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
YH65_08980	ENOG4105BZU	Histidine kinase
YH65_08985	ENOG4105GSH	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
YH65_08990	ENOG4105D17	glycoside hydrolase, family 3 domain protein
YH65_08995	ENOG4107USA	Thioredoxin
YH65_09000	ENOG4105C79	DNA protecting protein DprA
YH65_09015	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
YH65_09030	ENOG4108UQY	Iron-storage protein
YH65_09040	ENOG4108RAC	Rubrerythrin
YH65_09060	ENOG4105D0M	Protease HtpX homolog
YH65_09065	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
YH65_09070	ENOG4108VMB	DNA polymerase III subunit delta'
YH65_09075	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
YH65_09080	ENOG4108UUM	single-stranded DNA-binding protein
YH65_09085	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
YH65_09095	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
YH65_09100	ENOG4108VHG	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
YH65_09110	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
YH65_09125	ENOG4105C98	muts2 protein
YH65_09140	ENOG4105E33	succinate dehydrogenase
YH65_09145	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
YH65_09150	ENOG4108S24	Fumarate reduCtase
YH65_09155	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
YH65_09160	ENOG4105DFU	Cell wall formation (By similarity)
YH65_09180	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
YH65_09185	ENOG4105C87	Aminotransferase class I and II
YH65_09200	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
YH65_09205	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
YH65_09210	ENOG4105VIE	preprotein translocase, subunit YajC
YH65_09215	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
YH65_09220	ENOG4108512	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
YH65_09225	ENOG4105EKE	dihydroorotase
YH65_09230	ENOG4107B2H	carbonic anhydrase
YH65_09235	ENOG4105C6T	cysteine synthase
YH65_09250	ENOG4108M0I	Transcriptional regulator
YH65_09260	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
YH65_09265	ENOG4107Z7S	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
YH65_09275	ENOG4105VN1	Heat shock protein
YH65_09290	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
YH65_09295	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
YH65_09310	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
YH65_09315	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
YH65_09320	ENOG4105V3S	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
YH65_09325	ENOG4105VB6	UPF0109 protein
YH65_09330	ENOG4105K5M	30s ribosomal protein S16
YH65_09335	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
YH65_09340	ENOG4105EI2	Pseudouridine synthase
YH65_09345	ENOG4105VZ9	UPF0235 protein
YH65_09355	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
YH65_09365	ENOG4105EGD	dinuclear metal center protein, YbgI family
YH65_09370	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
YH65_09385	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
YH65_09390	ENOG4105CFP	Peptidase U32
YH65_09395	ENOG4107RVV	histidinol phosphate phosphatase, hisj family
YH65_09400	ENOG4105C5F	glutamine synthetase
YH65_09410	ENOG4108JQC	penicillin-binding protein 1A
YH65_09415	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
YH65_09420	ENOG4107YJQ	MAF-like protein
YH65_09430	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
YH65_09445	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
YH65_09450	ENOG4105CNI	cell division protein FtsW
YH65_09455	ENOG4105CJN	penicillin-binding protein
YH65_09460	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
YH65_09465	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
YH65_09470	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
YH65_09475	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
YH65_09480	ENOG4105CE9	30S ribosomal protein S2
YH65_09485	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YH65_09500	ENOG4105C0H	protease
YH65_09550	ENOG4108ZMS	Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity)
YH65_09555	ENOG4105GXZ	Ferredoxin-type protein NapH
YH65_09560	ENOG4108BGM	Quinol dehydrogenase periplasmic component
YH65_09565	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
YH65_09570	ENOG4105VG1	fes assembly suf system protein
YH65_09585	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
YH65_09600	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
YH65_09605	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
YH65_09610	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
YH65_09630	ENOG4105CMI	transporter
YH65_09640	ENOG4105CJ1	ABC, transporter
YH65_09680	ENOG4105CA0	peroxidase
YH65_09685	ENOG4108IXY	short-chain dehydrogenase reductase
YH65_09700	ENOG4108IXY	short-chain dehydrogenase reductase
YH65_09705	ENOG4107R4J	Chloride channel
YH65_09710	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
YH65_09715	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
YH65_09720	ENOG4108JPZ	Monovalent cation H antiporter subunit D
YH65_09735	ENOG4108JPZ	Monovalent cation H antiporter subunit D
YH65_09760	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
YH65_09770	ENOG4108I0Q	anthranilate phosphoribosyltransferase
YH65_09780	ENOG4106P6N	cytochrome d1 heme region
YH65_09785	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
YH65_09790	ENOG4105C1A	potassium transporter peripheral membrane
YH65_09810	ENOG4108VKQ	nitriC oxide reductase
YH65_09835	ENOG4105CM2	brancheD-chain amino acid aminotransferase
YH65_09845	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
YH65_09855	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
YH65_09860	ENOG4105C3M	thioredoxin reductase
YH65_09875	ENOG41082UM	UPF0102 protein
YH65_09900	ENOG4108HIZ	formate dehydrogenase alpha subunit
YH65_09910	ENOG4108VPT	UPF0234 protein
YH65_09920	ENOG4105D6E	homoserine dehydrogenase
YH65_09925	ENOG4105CHM	Aminotransferase
YH65_09935	ENOG4105C2N	RNA methyltransferase TrmH family group 3
YH65_09940	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
YH65_09945	ENOG41082DI	50s ribosomal protein l31
YH65_09950	ENOG4107YV6	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
YH65_09960	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
YH65_09965	ENOG4108N6H	6-pyruvoyl tetrahydrobiopterin synthase
YH65_09985	ENOG4107RDB	Major Facilitator
YH65_09995	ENOG4107XWN	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
YH65_10000	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
YH65_10005	ENOG4105EIX	cytochrome c1
YH65_10015	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
YH65_10025	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
YH65_10030	ENOG4108R6K	riboflavin synthase, subunit alpha
YH65_10050	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
YH65_10055	ENOG4105DDK	oxidoreductase, beta subunit
YH65_10060	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
YH65_10065	ENOG4105WGB	oxidoreductase, delta subunit
YH65_10070	ENOG4105EJ5	oxidoreductase gamma subunit
YH65_10085	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
YH65_10105	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
YH65_10115	ENOG4108UJD	30S ribosomal protein S9
YH65_10120	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
YH65_10125	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
YH65_10165	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
YH65_10170	ENOG4105CPF	Cell wall formation (By similarity)
YH65_10175	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
YH65_10185	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
YH65_10190	ENOG4105CYE	ATP phosphoribosyltransferase regulatory subunit
YH65_10195	ENOG4107UUH	Aminotransferase
YH65_10225	ENOG4108TN2	lmbE family
YH65_10260	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
YH65_10265	ENOG4105E63	Pfam:DUF178
YH65_10270	ENOG4105D4A	Cell wall formation (By similarity)
YH65_10295	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
YH65_10310	ENOG4105C58	cytochrome c oxidase accessory protein ccog
YH65_10320	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
YH65_10340	ENOG410813J	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
YH65_10345	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
YH65_10350	ENOG4108317	Binds directly to 16S ribosomal RNA (By similarity)
YH65_10355	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
YH65_10425	ENOG4105MPD	Cytochrome
YH65_10460	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
YH65_10465	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
YH65_10470	ENOG41084M8	50s ribosomal protein L35
YH65_10475	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
YH65_10535	ENOG4105EUU	Sel1 domain protein repeat-containing protein
YH65_10555	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
YH65_10560	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
YH65_10565	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
YH65_10570	ENOG4105KZZ	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
YH65_10575	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
YH65_10580	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
YH65_10585	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
YH65_10590	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
YH65_10595	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
YH65_10600	ENOG41084HJ	50s ribosomal protein l29
YH65_10605	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
YH65_10610	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
YH65_10615	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
YH65_10620	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
YH65_10625	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
YH65_10630	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
YH65_10635	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
YH65_10640	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
YH65_10645	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
YH65_10650	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
YH65_10655	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
YH65_10660	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
YH65_10665	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
YH65_10670	ENOG41067V7	50S ribosomal protein L36
YH65_10675	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
YH65_10680	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
YH65_10685	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
YH65_10690	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
YH65_10695	ENOG4108ZT0	50S ribosomal protein l17
YH65_10715	ENOG4109045	doxx family
YH65_10740	ENOG4105CI3	gtp-binding protein typa
YH65_10745	ENOG4105CBX	hi0933 family
YH65_10760	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
YH65_10765	ENOG4105BZG	amino acid carrier protein
YH65_10825	ENOG4105VTR	Integrase
YH65_10840	ENOG4105FE9	pseudouridine synthase
YH65_10845	ENOG4105C2X	Arabinose 5-phosphate isomerase
YH65_10855	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
YH65_10860	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
YH65_10870	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
YH65_10875	ENOG4105EI2	Pseudouridine synthase
YH65_10880	ENOG4107QTF	adenylosuccinate lyase
YH65_10885	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
YH65_10890	ENOG4105BZN	citrate synthase
YH65_10895	ENOG4105NBK	UPF0345 protein
YH65_10905	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
YH65_10915	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
YH65_10935	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
YH65_10960	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
YH65_10965	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
YH65_10985	ENOG4105C22	threonyL-tRNA synthetase
YH65_10990	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
YH65_10995	ENOG4105C01	Dihydroxy-acid dehydratase
YH65_11020	ENOG4105VTR	Integrase
YH65_11045	ENOG4105GVR	general secretion pathway protein D
YH65_11105	ENOG4108VKG	metal-dependent hydrolase
YH65_11120	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)