locus-tag	class	description
LN246_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LN246_00010	COG0592	DNA-directed DNA polymerase activity
LN246_00015	COG0504	CTP synthase activity
LN246_00020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LN246_00020	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LN246_00040	COG0243	molybdopterin cofactor binding
LN246_00045	COG0437	4 iron, 4 sulfur cluster binding
LN246_00055	COG0489	protein tyrosine kinase activity
LN246_00065	COG2906	2 iron, 2 sulfur cluster binding
LN246_00065	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LN246_00065	COG0822	iron-sulfur transferase activity
LN246_00085	COG1194	a g-specific adenine glycosylase
LN246_00090	COG1342	Belongs to the UPF0251 family
LN246_00135	COG0544	peptidyl-prolyl cis-trans isomerase activity
LN246_00140	COG0740	serine-type endopeptidase activity
LN246_00150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LN246_00160	COG2003	Belongs to the UPF0758 family
LN246_00165	COG2855	membrane
LN246_00170	COG0583	DNA-binding transcription factor activity
LN246_00175	COG0746	molybdenum cofactor guanylyltransferase activity
LN246_00180	COG2814	Major facilitator Superfamily
LN246_00195	COG1459	type II secretion system
LN246_00210	COG2165	general secretion pathway protein
LN246_00265	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LN246_00270	COG0233	cytoplasmic translational termination
LN246_00275	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LN246_00280	COG2890	protein-(glutamine-N5) methyltransferase activity
LN246_00285	COG0352	thiamine-phosphate diphosphorylase activity
LN246_00290	COG0670	Belongs to the BI1 family
LN246_00355	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LN246_00380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LN246_00385	COG0268	Binds directly to 16S ribosomal RNA
LN246_00390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LN246_00395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LN246_00410	COG2995	paraquat-inducible protein a
LN246_00420	COG0315	cyclic pyranopterin monophosphate synthase activity
LN246_00430	COG0348	domain, Protein
LN246_00455	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LN246_00480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LN246_00490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LN246_00495	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LN246_00515	COG0148	phosphopyruvate hydratase activity
LN246_00530	COG0714	Associated with various cellular activities
LN246_00535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LN246_00540	COG0717	Belongs to the dCTP deaminase family
LN246_00555	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LN246_00585	COG2244	polysaccharide biosynthetic process
LN246_00610	COG1215	transferase activity, transferring glycosyl groups
LN246_00630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LN246_00665	COG0314	molybdopterin synthase activity
LN246_00670	COG0303	'Molybdopterin
LN246_00710	COG0023	Translation Initiation Factor
LN246_00720	COG2239	Acts as a magnesium transporter
LN246_00725	COG3022	response to hydroperoxide
LN246_00750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LN246_00755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LN246_00770	COG0250	Participates in transcription elongation, termination and antitermination
LN246_00775	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LN246_00780	COG0081	regulation of translation
LN246_00785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LN246_00790	COG0222	ribosome binding
LN246_00795	COG0085	RNA polymerase activity
LN246_00800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LN246_00805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LN246_00810	COG0049	tRNA binding
LN246_00815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LN246_00835	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LN246_00840	COG2200	EAL domain
LN246_00845	COG0187	DNA topoisomerase II activity
LN246_00850	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LN246_00860	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LN246_00865	COG0575	Belongs to the CDS family
LN246_00875	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LN246_00910	COG1053	succinate dehydrogenase
LN246_00915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LN246_00920	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LN246_00925	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LN246_00935	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LN246_00935	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LN246_00940	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LN246_00965	COG0534	Mate efflux family protein
LN246_00980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LN246_01005	COG2814	Major facilitator Superfamily
LN246_01010	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LN246_01030	COG0745	RESPONSE REGULATOR receiver
LN246_01035	COG5002	protein histidine kinase activity
LN246_01035	COG3850	Histidine kinase
LN246_01040	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LN246_01045	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LN246_01050	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LN246_01060	COG0505	Belongs to the CarA family
LN246_01065	COG1181	Belongs to the D-alanine--D-alanine ligase family
LN246_01070	COG3278	Belongs to the heme-copper respiratory oxidase family
LN246_01105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LN246_01115	COG1074	ATP-dependent DNA helicase activity
LN246_01120	COG2197	response regulator
LN246_01125	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LN246_01130	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LN246_01165	COG0546	phosphoglycolate phosphatase activity
LN246_01170	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LN246_01175	COG1144	Oxidoreductase
LN246_01180	COG0674	pyruvate-flavodoxin oxidoreductase activity
LN246_01185	COG1013	pyruvate-flavodoxin oxidoreductase activity
LN246_01200	COG1854	S-ribosylhomocysteine lyase activity
LN246_01225	COG0445	tRNA wobble uridine modification
LN246_01260	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
LN246_01280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LN246_01285	COG2857	Cytochrome c1
LN246_01290	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LN246_01295	COG0602	queuosine metabolic process
LN246_01320	COG0303	'Molybdopterin
LN246_01330	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LN246_01345	COG0254	rRNA binding
LN246_01350	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LN246_01355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LN246_01365	COG0436	Aminotransferase
LN246_01370	COG0460	homoserine dehydrogenase
LN246_01375	COG1666	GTP binding
LN246_01385	COG3383	formate dehydrogenase (NAD+) activity
LN246_01390	COG1944	ATP diphosphatase activity
LN246_01395	COG0792	nuclease activity
LN246_01400	COG5285	phytanoyl-CoA dioxygenase
LN246_01405	COG3118	belongs to the thioredoxin family
LN246_01410	COG0492	ferredoxin-NADP+ reductase activity
LN246_01415	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LN246_01420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LN246_01425	COG0140	phosphoribosyl-ATP diphosphatase activity
LN246_01425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LN246_01445	COG1012	belongs to the aldehyde dehydrogenase family
LN246_01460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LN246_01470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LN246_01485	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LN246_01490	COG0288	reversible hydration of carbon dioxide
LN246_01495	COG0439	Biotin carboxylase
LN246_01505	COG1136	(ABC) transporter
LN246_01510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LN246_01515	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LN246_01525	COG0772	Belongs to the SEDS family
LN246_01530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LN246_01540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LN246_01550	COG0424	maF-like protein
LN246_01555	COG0156	8-amino-7-oxononanoate synthase activity
LN246_01575	COG0174	glutamine synthetase
LN246_01585	COG0826	peptidase U32
LN246_01595	COG0752	glycyl-tRNA synthetase alpha subunit
LN246_01600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LN246_01610	COG1519	Transferase
LN246_01620	COG0564	pseudouridine synthase activity
LN246_01625	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LN246_01630	COG0228	four-way junction DNA binding
LN246_01635	COG1837	Belongs to the UPF0109 family
LN246_01640	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LN246_01645	COG0336	Belongs to the RNA methyltransferase TrmD family
LN246_01650	COG0335	large ribosomal subunit rRNA binding
LN246_01690	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LN246_01700	COG0564	pseudouridine synthase activity
LN246_01715	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LN246_01720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LN246_01730	COG0583	DNA-binding transcription factor activity
LN246_01740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LN246_01755	COG0418	dihydroorotase activity
LN246_01770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LN246_01775	COG1862	Preprotein translocase
LN246_01780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LN246_01785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LN246_01795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LN246_01800	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LN246_01805	COG2027	D-alanyl-D-alanine carboxypeptidase
LN246_01810	COG0436	Aminotransferase
LN246_01825	COG1193	negative regulation of DNA recombination
LN246_01845	COG4974	Belongs to the 'phage' integrase family
LN246_01855	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LN246_01860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LN246_01895	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LN246_01900	COG3259	Nickel-dependent hydrogenase
LN246_01910	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LN246_01915	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LN246_01920	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
LN246_01945	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LN246_01985	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LN246_01990	COG0298	carbon dioxide binding
LN246_01995	COG0409	Hydrogenase expression formation protein
LN246_02000	COG0309	Hydrogenase expression formation protein (HypE)
LN246_02005	COG1024	Enoyl-CoA hydratase
LN246_02005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LN246_02010	COG0375	protein maturation
LN246_02025	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LN246_02030	COG0629	single-stranded DNA binding
LN246_02035	COG0360	Binds together with S18 to 16S ribosomal RNA
LN246_02040	COG1466	dna polymerase III delta subunit
LN246_02045	COG0557	exoribonuclease II activity
LN246_02050	COG0501	Belongs to the peptidase M48B family
LN246_02060	COG3292	Two component regulator propeller
LN246_02060	COG2205	protein histidine kinase activity
LN246_02060	COG0745	RESPONSE REGULATOR receiver
LN246_02065	COG5002	protein histidine kinase activity
LN246_02090	COG0737	Belongs to the 5'-nucleotidase family
LN246_02100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LN246_02155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LN246_02160	COG2861	carbohydrate metabolic process
LN246_02165	COG0471	metal ion transport
LN246_02210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LN246_02215	COG1136	(ABC) transporter
LN246_02215	COG0577	efflux transmembrane transporter activity
LN246_02220	COG0577	efflux transmembrane transporter activity
LN246_02220	COG1136	(ABC) transporter
LN246_02225	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LN246_02235	COG2205	protein histidine kinase activity
LN246_02235	COG3437	response regulator, receiver
LN246_02235	COG3850	Histidine kinase
LN246_02235	COG4999	Histidine kinase
LN246_02245	COG0791	NLP P60 protein
LN246_02250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LN246_02255	COG0805	protein transport
LN246_02260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LN246_02265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LN246_02270	COG0494	nUDIX hydrolase
LN246_02275	COG0527	aspartate kinase activity
LN246_02290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LN246_02295	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LN246_02310	COG0196	riboflavin kinase activity
LN246_02315	COG1073	alpha beta
LN246_02325	COG2226	methyltransferase
LN246_02330	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LN246_02335	COG0642	Histidine kinase
LN246_02340	COG0745	RESPONSE REGULATOR receiver
LN246_02350	COG4753	response regulator
LN246_02350	COG2207	Transcriptional regulator
LN246_02355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LN246_02360	COG4772	TonB-dependent receptor
LN246_02375	COG0348	domain, Protein
LN246_02375	COG3901	Regulator of nitric oxide reductase transcription
LN246_02380	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
LN246_02390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LN246_02400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LN246_02415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LN246_02430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LN246_02450	COG1393	Belongs to the ArsC family
LN246_02455	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LN246_02470	COG3150	esterase
LN246_02475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LN246_02485	COG5002	protein histidine kinase activity
LN246_02525	COG0280	phosphate acetyltransferase
LN246_02525	COG0281	malic enzyme
LN246_02535	COG2046	Belongs to the sulfate adenylyltransferase family
LN246_02540	COG0745	RESPONSE REGULATOR receiver
LN246_02545	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LN246_02545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LN246_02550	COG0489	protein tyrosine kinase activity
LN246_02565	COG3746	phosphate-selective porin O and P
LN246_02590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LN246_02595	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LN246_02600	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LN246_02610	COG0512	Glutamine amidotransferase of anthranilate synthase
LN246_02690	COG0165	Argininosuccinate lyase
LN246_02735	COG2239	Acts as a magnesium transporter
LN246_02740	COG2022	thiamine diphosphate biosynthetic process
LN246_02755	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LN246_02775	COG4771	TonB-dependent receptor
LN246_02780	COG0537	adenosine 5'-monophosphoramidase activity
LN246_02785	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LN246_02790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LN246_02790	COG0072	phenylalanine-tRNA ligase activity
LN246_02795	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LN246_02800	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LN246_02805	COG0539	negative regulation of cytoplasmic translation
LN246_02805	COG1185	polyribonucleotide nucleotidyltransferase activity
LN246_02810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LN246_02830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LN246_02835	COG0693	protein deglycase activity
LN246_02840	COG0587	DNA-directed DNA polymerase activity
LN246_02860	COG0039	L-malate dehydrogenase activity
LN246_02865	COG0039	L-malate dehydrogenase activity
LN246_02875	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LN246_02875	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LN246_02880	COG0114	fumarate hydratase activity
LN246_02885	COG0045	succinate-CoA ligase (ADP-forming) activity
LN246_02890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LN246_02905	COG0674	pyruvate-flavodoxin oxidoreductase activity
LN246_02905	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LN246_02910	COG1013	pyruvate-flavodoxin oxidoreductase activity
LN246_02990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LN246_03100	COG3941	tape measure
LN246_03250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LN246_03360	COG3941	tape measure
LN246_03470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LN246_03490	COG0736	holo-[acyl-carrier-protein] synthase activity
LN246_03495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LN246_03505	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LN246_03515	COG0552	protein localization to endoplasmic reticulum
LN246_03530	COG1418	mRNA catabolic process
LN246_03545	COG0500	methyltransferase
LN246_03550	COG0745	RESPONSE REGULATOR receiver
LN246_03555	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LN246_03555	COG2050	protein possibly involved in aromatic compounds catabolism
LN246_03565	COG2833	Protein of unknown function (DUF455)
LN246_03570	COG1663	tetraacyldisaccharide 4'-kinase activity
LN246_03575	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LN246_03580	COG1858	cytochrome C peroxidase
LN246_03585	COG3300	MHYT domain
LN246_03585	COG5001	Diguanylate cyclase
LN246_03590	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LN246_03605	COG0488	(ABC) transporter
LN246_03610	COG0501	Belongs to the peptidase M48B family
LN246_03615	COG2890	protein-(glutamine-N5) methyltransferase activity
LN246_03630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LN246_03650	COG0754	glutathionylspermidine amidase activity
LN246_03665	COG0849	cell division
LN246_03670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LN246_03675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LN246_03690	COG0275	rRNA processing
LN246_03710	COG0142	geranyltranstransferase activity
LN246_03715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LN246_03720	COG0442	prolyl-tRNA aminoacylation
LN246_03735	COG0181	hydroxymethylbilane synthase activity
LN246_03740	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LN246_03745	COG0450	alkyl hydroperoxide reductase
LN246_03755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LN246_03870	COG0750	zinc metalloprotease
LN246_03880	COG1918	ferrous iron import across plasma membrane
LN246_03885	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LN246_03900	COG1028	Short-chain dehydrogenase reductase Sdr
LN246_03905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LN246_03910	COG0612	Peptidase, M16
LN246_03915	COG0167	dihydroorotate dehydrogenase activity
LN246_03925	COG1132	(ABC) transporter
LN246_03930	COG0215	cysteine-tRNA ligase activity
LN246_03935	COG0728	peptidoglycan biosynthetic process
LN246_04000	COG4191	Histidine kinase
LN246_04005	COG0745	RESPONSE REGULATOR receiver
LN246_04010	COG0446	pyridine nucleotide-disulphide oxidoreductase
LN246_04025	COG1368	sulfuric ester hydrolase activity
LN246_04030	COG0632	four-way junction helicase activity
LN246_04035	COG1388	LysM domain
LN246_04035	COG0791	NLP P60 protein
LN246_04040	COG2081	HI0933 family
LN246_04070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LN246_04120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LN246_04150	COG0714	Associated with various cellular activities
LN246_04160	COG3001	Fructosamine kinase
LN246_04165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LN246_04180	COG3842	ATPase activity
LN246_04205	COG0439	Biotin carboxylase
LN246_04230	COG2824	Alkylphosphonate utilization operon protein PhnA
LN246_04245	COG0070	glutamate synthase
LN246_04245	COG0069	glutamate synthase activity
LN246_04245	COG0067	glutamate synthase
LN246_04255	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LN246_04260	COG0352	thiamine-phosphate diphosphorylase activity
LN246_04295	COG0343	queuine tRNA-ribosyltransferase activity
LN246_04305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LN246_04315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LN246_04320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LN246_04340	COG0300	oxidoreductase activity
LN246_04350	COG0521	Mo-molybdopterin cofactor biosynthetic process
LN246_04365	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LN246_04400	COG2217	Heavy metal translocating P-type atpase
LN246_04425	COG0156	8-amino-7-oxononanoate synthase activity
LN246_04455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LN246_04475	COG0659	secondary active sulfate transmembrane transporter activity
LN246_04480	COG0617	tRNA 3'-terminal CCA addition
LN246_04485	COG0778	Nitroreductase
LN246_04490	COG2860	membrane
LN246_04515	COG0579	oxidoreductase
LN246_04535	COG0318	PFAM AMP-dependent synthetase and ligase
LN246_04545	COG0673	inositol 2-dehydrogenase activity
LN246_04555	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LN246_04555	COG0674	pyruvate-flavodoxin oxidoreductase activity
LN246_04555	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LN246_04555	COG1013	pyruvate-flavodoxin oxidoreductase activity
LN246_04560	COG1643	Atp-dependent helicase
LN246_04565	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LN246_04570	COG3123	guanosine phosphorylase activity
LN246_04575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LN246_04580	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LN246_04585	COG1012	belongs to the aldehyde dehydrogenase family
LN246_04640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LN246_04655	COG0189	ligase activity
LN246_04675	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LN246_04680	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LN246_04690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LN246_04700	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LN246_04710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LN246_04710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LN246_04740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LN246_04740	COG1333	cytochrome c biogenesis protein
LN246_04770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LN246_04775	COG0463	Glycosyl transferase, family 2
LN246_04785	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LN246_04795	COG0585	pseudouridine synthase activity
LN246_04815	COG1254	Belongs to the acylphosphatase family
LN246_04835	COG3588	fructose-bisphosphate aldolase
LN246_04910	COG3118	belongs to the thioredoxin family
LN246_04915	COG0745	RESPONSE REGULATOR receiver
LN246_04920	COG0642	Histidine kinase
LN246_04955	COG1959	2 iron, 2 sulfur cluster binding
LN246_04985	COG1136	(ABC) transporter
LN246_04985	COG0577	efflux transmembrane transporter activity
LN246_04990	COG1136	(ABC) transporter
LN246_04990	COG0577	efflux transmembrane transporter activity
LN246_05010	COG0402	S-adenosylhomocysteine deaminase activity
LN246_05015	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LN246_05020	COG0006	proline dipeptidase activity
LN246_05025	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LN246_05030	COG1419	protein localization to endoplasmic reticulum
LN246_05040	COG0482	sulfurtransferase activity
LN246_05050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LN246_05055	COG0481	GTPase activity
LN246_05070	COG1294	oxidase, subunit
LN246_05075	COG1271	oxidase subunit
LN246_05085	COG1342	Belongs to the UPF0251 family
LN246_05110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LN246_05110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LN246_05120	COG2827	Endonuclease containing a URI domain
LN246_05130	COG1309	transcriptional regulator
LN246_05155	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LN246_05160	COG1763	Mo-molybdopterin cofactor biosynthetic process
LN246_05175	COG0762	integral membrane protein
LN246_05180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LN246_05185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LN246_05190	COG1881	PFAM PEBP family protein
LN246_05245	COG0667	Aldo Keto reductase
LN246_05255	COG1943	Transposase
LN246_05260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LN246_05265	COG0708	Exodeoxyribonuclease III
LN246_05295	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LN246_05315	COG2353	YceI-like domain
LN246_05335	COG0628	permease
LN246_05340	COG0563	adenylate kinase activity
LN246_05345	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LN246_05350	COG2354	Protein conserved in bacteria
LN246_05375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LN246_05385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LN246_05390	COG0497	DNA recombination
LN246_05395	COG5001	Diguanylate cyclase
LN246_05395	COG3300	MHYT domain
LN246_05465	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LN246_05475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LN246_05525	COG0640	Transcriptional regulator
LN246_05535	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LN246_05540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LN246_05545	COG1121	(ABC) transporter
LN246_05550	COG0803	Belongs to the bacterial solute-binding protein 9 family
LN246_05565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LN246_05590	COG0012	GTP binding
LN246_05595	COG4999	Histidine kinase
LN246_05595	COG2205	protein histidine kinase activity
LN246_05595	COG3850	Histidine kinase
LN246_05595	COG3437	response regulator, receiver
LN246_05600	COG2703	oxygen carrier activity
LN246_05605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LN246_05610	COG0133	tryptophan synthase activity
LN246_05615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LN246_05655	COG0698	ribose 5-phosphate isomerase
LN246_05660	COG0681	Belongs to the peptidase S26 family
LN246_05665	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LN246_05685	COG1607	acyl-coa hydrolase
LN246_05700	COG0189	ligase activity
LN246_05700	COG4067	protein conserved in archaea
LN246_05715	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LN246_05715	COG3264	Mechanosensitive ion channel
LN246_05725	COG0563	adenylate kinase activity
LN246_05735	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LN246_05740	COG0189	ligase activity
LN246_05745	COG0561	phosphatase activity
LN246_05750	COG1032	radical SAM domain protein
LN246_05755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LN246_05760	COG3228	Belongs to the MtfA family
LN246_05765	COG1858	cytochrome C peroxidase
LN246_05770	COG3437	response regulator, receiver
LN246_05770	COG2770	Histidine kinase
LN246_05780	COG1671	Belongs to the UPF0178 family
LN246_05785	COG4895	conserved protein (DUF2196)
LN246_05810	COG2966	Psort location CytoplasmicMembrane, score
LN246_05845	COG0590	tRNA wobble adenosine to inosine editing
LN246_05860	COG2814	Major facilitator Superfamily
LN246_05915	COG0301	tRNA thio-modification
LN246_05915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LN246_05920	COG1611	Belongs to the LOG family
LN246_05935	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LN246_05940	COG0574	Belongs to the PEP-utilizing enzyme family
LN246_05940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LN246_05985	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LN246_05990	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LN246_06010	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LN246_06025	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LN246_06040	COG1067	ATP-dependent peptidase activity
LN246_06100	COG1119	ATPase activity
LN246_06115	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LN246_06140	COG2048	Heterodisulfide reductase, subunit B
LN246_06185	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LN246_06190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LN246_06195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LN246_06235	COG0659	secondary active sulfate transmembrane transporter activity
LN246_06240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LN246_06255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LN246_06265	COG1077	Cell shape determining protein MreB Mrl
LN246_06270	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LN246_06275	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LN246_06280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LN246_06295	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LN246_06295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LN246_06300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LN246_06305	COG0284	orotidine-5'-phosphate decarboxylase activity
LN246_06380	COG0582	viral genome integration into host DNA
LN246_06410	COG2207	Transcriptional regulator
LN246_06415	COG1064	alcohol dehydrogenase
LN246_06450	COG1028	Short-chain dehydrogenase reductase Sdr
LN246_06455	COG1979	alcohol dehydrogenase
LN246_06460	COG0519	Catalyzes the synthesis of GMP from XMP
LN246_06480	COG1047	Peptidyl-prolyl cis-trans
LN246_06490	COG0585	pseudouridine synthase activity
LN246_06500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LN246_06520	COG1278	Cold shock
LN246_06525	COG0084	hydrolase, TatD family'
LN246_06535	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LN246_06540	COG0131	Imidazoleglycerol-phosphate dehydratase
LN246_06545	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LN246_06575	COG0768	penicillin binding
LN246_06590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LN246_06595	COG1120	ATPase activity
LN246_06605	COG2226	methyltransferase
LN246_06620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LN246_06625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LN246_06630	COG0811	peptide transport
LN246_06635	COG0848	biopolymer transport protein
LN246_06640	COG4206	TonB-dependent receptor
LN246_06650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LN246_06655	COG0500	methyltransferase
LN246_06760	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LN246_06760	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LN246_06770	COG0745	RESPONSE REGULATOR receiver
LN246_06780	COG3162	membrane
LN246_06785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LN246_06795	COG2176	DNA-directed DNA polymerase activity
LN246_06800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LN246_06815	COG2133	pyrroloquinoline quinone binding
LN246_06840	COG0069	glutamate synthase activity
LN246_06855	COG2824	Alkylphosphonate utilization operon protein PhnA
LN246_06860	COG1011	Hydrolase
LN246_06865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LN246_06875	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LN246_06885	COG1943	Transposase
LN246_06895	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LN246_06900	COG2081	HI0933 family
LN246_06925	COG1309	transcriptional regulator
LN246_06930	COG2897	thiosulfate sulfurtransferase activity
LN246_06955	COG0513	Belongs to the DEAD box helicase family
LN246_06995	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LN246_07010	COG3384	dioxygenase
LN246_07020	COG2801	Transposase and inactivated derivatives
LN246_07020	COG3415	Transposase
LN246_07030	COG4948	Mandelate Racemase Muconate Lactonizing
LN246_07040	COG0742	ribosomal rna small subunit methyltransferase
LN246_07070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LN246_07090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LN246_07095	COG1234	tRNA 3'-trailer cleavage
LN246_07110	COG2909	trisaccharide binding
LN246_07120	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LN246_07195	COG3021	interspecies interaction between organisms
LN246_07225	COG1757	Na H antiporter
LN246_07235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LN246_07245	COG0531	amino acid
LN246_07250	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LN246_07255	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LN246_07275	COG2304	oxidoreductase activity
LN246_07285	COG0714	Associated with various cellular activities
LN246_07295	COG2095	MarC family integral membrane protein
LN246_07315	COG0840	transmembrane signaling receptor activity
LN246_07320	COG1704	LemA family
LN246_07335	COG0542	response to heat
LN246_07340	COG0793	Belongs to the peptidase S41A family
LN246_07345	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LN246_07350	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LN246_07355	COG0047	phosphoribosylformylglycinamidine synthase activity
LN246_07365	COG0204	Acyl-transferase
LN246_07370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LN246_07380	COG0475	glutathione-regulated potassium exporter activity
LN246_07400	COG2863	cytochrome
LN246_07405	COG3328	transposase activity
LN246_07410	COG0640	Transcriptional regulator
LN246_07430	COG0745	RESPONSE REGULATOR receiver
LN246_07435	COG0642	Histidine kinase
LN246_07450	COG0513	Belongs to the DEAD box helicase family
LN246_07460	COG4536	flavin adenine dinucleotide binding
LN246_07465	COG2239	Acts as a magnesium transporter
LN246_07475	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LN246_07500	COG1968	undecaprenyl-diphosphatase activity
LN246_07505	COG1132	(ABC) transporter
LN246_07510	COG0560	Phosphoserine phosphatase
LN246_07520	COG2827	Endonuclease containing a URI domain
LN246_07525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LN246_07530	COG2814	Major facilitator Superfamily
LN246_07535	COG1238	metal cluster binding
LN246_07545	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LN246_07550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LN246_07555	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LN246_07560	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LN246_07580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LN246_07585	COG0525	valine-tRNA ligase activity
LN246_07620	COG0071	Belongs to the small heat shock protein (HSP20) family
LN246_07625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LN246_07640	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LN246_07645	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LN246_07655	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LN246_07660	COG0298	carbon dioxide binding
LN246_07670	COG0309	Hydrogenase expression formation protein (HypE)
LN246_07675	COG0375	protein maturation
LN246_07680	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LN246_07685	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LN246_07690	COG1573	uracil-dna glycosylase
LN246_07695	COG3585	molybdate ion transport
LN246_07700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LN246_07710	COG1355	regulation of microtubule-based process
LN246_07720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LN246_07745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LN246_07755	COG0583	DNA-binding transcription factor activity
LN246_07760	COG0179	Fumarylacetoacetate (FAA) hydrolase
LN246_07810	COG0123	including yeast histone deacetylase and acetoin utilization protein
LN246_07840	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LN246_07840	COG3008	intermembrane lipid transfer
LN246_07845	COG2995	paraquat-inducible protein a
LN246_07855	COG1597	lipid kinase activity
LN246_07870	COG2808	Putative FMN-binding domain
LN246_07880	COG0456	acetyltransferase
LN246_07895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LN246_07905	COG0668	transmembrane transport
LN246_07925	COG1278	Cold shock
LN246_07930	COG1451	nucleotide metabolic process
LN246_07940	COG2951	lytic endotransglycosylase activity
LN246_07985	COG0189	ligase activity
LN246_07995	COG0824	Thioesterase
LN246_08015	COG4771	TonB-dependent receptor
LN246_08020	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LN246_08035	COG0716	FMN binding
LN246_08070	COG1049	propionate catabolic process, 2-methylcitrate cycle
LN246_08075	COG1196	nuclear chromosome segregation
LN246_08075	COG1674	ftsk spoiiie
LN246_08100	COG0163	prenyltransferase activity
LN246_08105	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LN246_08110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LN246_08115	COG0124	histidyl-tRNA synthetase
LN246_08135	COG1127	ABC transporter
LN246_08140	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LN246_08145	COG1166	arginine decarboxylase activity
LN246_08150	COG1045	serine acetyltransferase
LN246_08185	COG0772	Belongs to the SEDS family
LN246_08235	COG0514	ATP-dependent DNA helicase (RecQ)
LN246_08295	COG2033	superoxide reductase activity
LN246_08350	COG2204	response regulator
LN246_08390	COG0426	domain, Protein
LN246_08410	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LN246_08425	COG1053	succinate dehydrogenase
LN246_08430	COG0667	Aldo Keto reductase
LN246_08450	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LN246_08455	COG0633	Ferredoxin
LN246_08460	COG0543	2 iron, 2 sulfur cluster binding
LN246_08460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LN246_08475	COG0716	FMN binding
LN246_08485	COG1433	Dinitrogenase iron-molybdenum cofactor
LN246_08490	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LN246_08495	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LN246_08510	COG4989	oxidoreductase activity
LN246_08550	COG0647	UMP catabolic process
LN246_08580	COG0686	Belongs to the AlaDH PNT family
LN246_08600	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LN246_08605	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LN246_08615	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
LN246_08620	COG1278	Cold shock
LN246_08675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LN246_08700	COG0740	serine-type endopeptidase activity
LN246_08705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LN246_08735	COG1280	lysine exporter protein (LysE YggA)
LN246_08755	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LN246_08805	COG0129	dihydroxy-acid dehydratase activity
LN246_08815	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LN246_08835	COG1215	transferase activity, transferring glycosyl groups
LN246_08840	COG2379	hydroxypyruvate reductase
LN246_08845	COG3769	mannosylglycerate metabolic process
LN246_08870	COG0842	Transport permease protein
LN246_08875	COG0842	Transport permease protein
LN246_08875	COG1129	ABC transporter
LN246_08880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LN246_08885	COG0045	succinate-CoA ligase (ADP-forming) activity
LN246_08885	COG1042	CoA-binding domain protein
LN246_08885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LN246_08900	COG1971	Probably functions as a manganese efflux pump
LN246_08910	COG0693	protein deglycase activity
LN246_08925	COG2270	Major facilitator Superfamily
LN246_08930	COG0584	glycerophosphoryl diester phosphodiesterase
LN246_08945	COG0415	Belongs to the DNA photolyase family
LN246_08950	COG0259	pyridoxamine-phosphate oxidase activity
LN246_08960	COG1401	restriction endodeoxyribonuclease activity
LN246_09010	COG2989	Protein conserved in bacteria
LN246_09015	COG0702	epimerase
LN246_09030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LN246_09040	COG4221	oxidoreductase activity
LN246_09045	COG1846	Transcriptional regulator
LN246_09050	COG3040	lipid binding
LN246_09065	COG0386	Belongs to the glutathione peroxidase family
LN246_09070	COG1090	epimerase
LN246_09075	COG1309	transcriptional regulator
LN246_09110	COG0674	pyruvate-flavodoxin oxidoreductase activity
LN246_09110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LN246_09115	COG1013	pyruvate-flavodoxin oxidoreductase activity
LN246_09120	COG0789	Transcriptional regulator
LN246_09125	COG0484	heat shock protein binding
LN246_09150	COG0138	bifunctional purine biosynthesis protein purh
LN246_09160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LN246_09180	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LN246_09190	COG0706	membrane insertase activity
LN246_09195	COG0594	ribonuclease P activity
LN246_09200	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LN246_09215	COG3850	Histidine kinase
LN246_09215	COG4999	Histidine kinase
LN246_09215	COG2205	protein histidine kinase activity
LN246_09215	COG3437	response regulator, receiver
LN246_09230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LN246_09235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LN246_09240	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LN246_09245	COG0616	signal peptide processing
LN246_09250	COG0352	thiamine-phosphate diphosphorylase activity
LN246_09260	COG0356	it plays a direct role in the translocation of protons across the membrane
LN246_09270	COG1137	ATPase activity
LN246_09275	COG0802	atpase or kinase
LN246_09280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LN246_09295	COG2171	N-acyltransferase activity
LN246_09305	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LN246_09325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LN246_09340	COG0489	protein tyrosine kinase activity
LN246_09365	COG0577	efflux transmembrane transporter activity
LN246_09365	COG1136	(ABC) transporter
LN246_09405	COG0731	radical SAM domain protein
LN246_09415	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LN246_09425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LN246_09435	COG0811	peptide transport
LN246_09440	COG0848	biopolymer transport protein
LN246_09445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LN246_09450	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LN246_09455	COG0217	transcriptional regulatory protein
LN246_09495	COG0488	(ABC) transporter
LN246_09500	COG1393	Belongs to the ArsC family
LN246_09505	COG2326	polyphosphate kinase activity
LN246_09510	COG1322	Protein conserved in bacteria
LN246_09515	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LN246_09520	COG0653	protein targeting
LN246_09535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LN246_09555	COG0004	ammonium transporteR
LN246_09565	COG0004	ammonium transporteR
LN246_09580	COG1739	Uncharacterized protein family UPF0029
LN246_09585	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LN246_09590	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LN246_09595	COG1459	type II secretion system
LN246_09600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LN246_09640	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LN246_09645	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LN246_09650	COG0359	binds to the 23S rRNA
LN246_09655	COG0339	signal peptide processing
LN246_09670	COG0137	argininosuccinate synthase activity
LN246_09685	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LN246_09690	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LN246_09695	COG0739	heme binding
LN246_09720	COG1610	YqeY-like protein
LN246_09730	COG0134	indole-3-glycerol-phosphate synthase activity
LN246_09740	COG0727	PFAM Uncharacterised protein family (UPF0153)
LN246_09755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LN246_09755	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LN246_09780	COG0788	formyltetrahydrofolate deformylase activity
LN246_09785	COG0473	3-isopropylmalate dehydrogenase activity
LN246_09790	COG0066	3-isopropylmalate dehydratase activity
LN246_09795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LN246_09805	COG1058	Belongs to the CinA family
LN246_09805	COG1546	Belongs to the CinA family
LN246_09815	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LN246_09835	COG0860	N-Acetylmuramoyl-L-alanine amidase
LN246_09840	COG0860	N-Acetylmuramoyl-L-alanine amidase
LN246_09850	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LN246_09860	COG1758	RNA polymerase activity
LN246_09865	COG0528	UMP kinase activity
LN246_09885	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LN246_09895	COG0564	pseudouridine synthase activity
LN246_09900	COG0037	tRNA processing
LN246_09905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LN246_09910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LN246_09935	COG1047	Peptidyl-prolyl cis-trans
LN246_09955	COG0823	Involved in the tonB-independent uptake of proteins
LN246_09960	COG0077	Prephenate dehydratase
LN246_09975	COG0686	Belongs to the AlaDH PNT family
LN246_09985	COG0848	biopolymer transport protein
LN246_09990	COG0811	peptide transport
LN246_09995	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LN246_10000	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LN246_10005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LN246_10010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LN246_10015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LN246_10020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LN246_10030	COG1475	DNA binding
LN246_10035	COG1192	Involved in chromosome partitioning
LN246_10045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LN246_10050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LN246_10055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LN246_10060	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LN246_10065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LN246_10070	COG0251	oxidation-reduction process
LN246_10080	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LN246_10095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LN246_10105	COG0516	GMP reductase activity
LN246_10105	COG0517	IMP dehydrogenase activity
LN246_10110	COG0154	amidase activity
LN246_10115	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LN246_10120	COG1058	Belongs to the CinA family
LN246_10120	COG1546	Belongs to the CinA family
LN246_10185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LN246_10195	COG0191	fructose-bisphosphate aldolase activity
LN246_10205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LN246_10220	COG2801	Transposase and inactivated derivatives
LN246_10220	COG3415	Transposase
LN246_10225	COG2326	polyphosphate kinase activity
LN246_10230	COG2195	Cleaves the N-terminal amino acid of tripeptides
LN246_10245	COG0133	tryptophan synthase activity
LN246_10270	COG0646	methionine synthase
LN246_10270	COG1410	methionine synthase
LN246_10275	COG0840	transmembrane signaling receptor activity
LN246_10285	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LN246_10290	COG0440	acetolactate synthase activity
LN246_10295	COG0028	Belongs to the TPP enzyme family
LN246_10305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LN246_10310	COG1832	CoA-binding protein
LN246_10315	COG2951	lytic endotransglycosylase activity
LN246_10320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LN246_10325	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LN246_10335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LN246_10340	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LN246_10350	COG0101	tRNA pseudouridine synthase activity
LN246_10365	COG1981	membrane
LN246_10375	COG3753	Protein conserved in bacteria
LN246_10380	COG2996	Protein conserved in bacteria
LN246_10410	COG4232	protein-disulfide reductase activity
LN246_10415	COG1331	Highly conserved protein containing a thioredoxin domain
LN246_10440	COG0642	Histidine kinase
LN246_10445	COG0745	RESPONSE REGULATOR receiver
LN246_10460	COG2226	methyltransferase
LN246_10465	COG0443	Heat shock 70 kDa protein
LN246_10470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LN246_10475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LN246_10480	COG1959	2 iron, 2 sulfur cluster binding
LN246_10485	COG2404	hydrolase activity, acting on ester bonds
LN246_10490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LN246_10500	COG0484	heat shock protein binding
LN246_10505	COG0501	Belongs to the peptidase M48B family
LN246_10510	COG1704	LemA family
LN246_10520	COG2193	ferroxidase activity
LN246_10525	COG0428	transporter
LN246_10545	COG0776	regulation of translation
LN246_10565	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LN246_10570	COG1185	polyribonucleotide nucleotidyltransferase activity
LN246_10580	COG0484	heat shock protein binding
LN246_10615	COG0326	Molecular chaperone. Has ATPase activity
LN246_10630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LN246_10630	COG0519	Catalyzes the synthesis of GMP from XMP
LN246_10640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LN246_10650	COG0322	excinuclease ABC activity
LN246_10655	COG0840	transmembrane signaling receptor activity
LN246_10675	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LN246_10680	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LN246_10725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LN246_10735	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LN246_10740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LN246_10745	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LN246_10750	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LN246_10760	COG2326	polyphosphate kinase activity
LN246_10785	COG0848	biopolymer transport protein
LN246_10795	COG0668	transmembrane transport
LN246_10800	COG1160	GTP binding
LN246_10825	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LN246_10830	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LN246_10840	COG2217	Heavy metal translocating P-type atpase
LN246_10855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LN246_10860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LN246_10865	COG0166	Belongs to the GPI family
LN246_10875	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LN246_10880	COG1028	Short-chain dehydrogenase reductase Sdr
LN246_10885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LN246_10900	COG0438	transferase activity, transferring glycosyl groups
LN246_10905	COG0438	transferase activity, transferring glycosyl groups
LN246_10910	COG0297	glycogen (starch) synthase activity
LN246_10925	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LN246_10930	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LN246_10935	COG2264	protein methyltransferase activity
LN246_10940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LN246_10945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LN246_10950	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LN246_10985	COG0582	viral genome integration into host DNA
LN246_11000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LN246_11005	COG0459	protein refolding
LN246_11015	COG1570	exodeoxyribonuclease VII activity
LN246_11025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LN246_11025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LN246_11030	COG0779	Required for maturation of 30S ribosomal subunits
LN246_11035	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LN246_11040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LN246_11050	COG0083	homoserine kinase activity
LN246_11060	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LN246_11065	COG0739	heme binding
LN246_11070	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LN246_11075	COG0157	Belongs to the NadC ModD family
LN246_11080	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LN246_11085	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LN246_11095	COG0745	RESPONSE REGULATOR receiver
LN246_11100	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LN246_11110	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LN246_11115	COG0287	Prephenate dehydrogenase
LN246_11135	COG2304	oxidoreductase activity
LN246_11155	COG0714	Associated with various cellular activities
LN246_11205	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LN246_11210	COG0285	dihydrofolate synthase activity
LN246_11220	COG0495	leucyl-tRNA aminoacylation
LN246_11225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LN246_11230	COG1692	metallophosphoesterase
LN246_11235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LN246_11240	COG0416	fatty acid biosynthetic process
LN246_11245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LN246_11255	COG0105	UTP biosynthetic process
LN246_11265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LN246_11270	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LN246_11280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LN246_11285	COG0077	Prephenate dehydratase
LN246_11285	COG1605	Chorismate mutase
LN246_11290	COG0019	diaminopimelate decarboxylase activity
LN246_11300	COG0193	aminoacyl-tRNA hydrolase activity
LN246_11305	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LN246_11315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LN246_11320	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LN246_11325	COG0542	response to heat
LN246_11330	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LN246_11335	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LN246_11340	COG0540	Belongs to the ATCase OTCase family
LN246_11345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LN246_11360	COG0705	Rhomboid family
LN246_11375	COG0357	Ribosomal RNA small subunit methyltransferase G
LN246_11385	COG0367	asparagine synthase
LN246_11405	COG1132	(ABC) transporter
LN246_11410	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LN246_11415	COG0113	porphobilinogen synthase activity
LN246_11420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LN246_11425	COG0247	lactate metabolic process
LN246_11430	COG0642	Histidine kinase
LN246_11435	COG0745	RESPONSE REGULATOR receiver
LN246_11440	COG0628	permease
LN246_11445	COG2255	four-way junction helicase activity
LN246_11450	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LN246_11455	COG0159	tryptophan synthase activity
LN246_11460	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LN246_11465	COG1924	4 iron, 4 sulfur cluster binding
LN246_11480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LN246_11485	COG1301	dicarboxylic acid transport
LN246_11495	COG3842	ATPase activity
LN246_11500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LN246_11515	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LN246_11600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LN246_11610	COG2957	Belongs to the agmatine deiminase family
LN246_11635	COG0739	heme binding
LN246_11645	COG0277	FAD linked oxidase domain protein
LN246_11650	COG1295	ribonuclease BN
LN246_11670	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LN246_11680	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LN246_11685	COG2165	general secretion pathway protein
LN246_11715	COG0556	nucleotide-excision repair
LN246_11720	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LN246_11725	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LN246_11735	COG2176	DNA-directed DNA polymerase activity
LN246_11740	COG0135	phosphoribosylanthranilate isomerase activity
LN246_11745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LN246_11750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LN246_11755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LN246_11760	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LN246_11770	COG0513	Belongs to the DEAD box helicase family
LN246_11775	COG0586	Pfam SNARE associated Golgi protein
LN246_11780	COG0825	malonyl-CoA metabolic process
LN246_11785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LN246_11790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LN246_11805	COG1136	(ABC) transporter
LN246_11840	COG5002	protein histidine kinase activity
LN246_11865	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LN246_11870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LN246_11885	COG0194	GDP metabolic process
LN246_11890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LN246_11910	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LN246_11915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LN246_11925	COG0149	triose-phosphate isomerase activity
LN246_11940	COG0195	Participates in both transcription termination and antitermination
LN246_11950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LN246_11955	COG2121	Domain of unknown function (DUF374)
LN246_11960	COG4974	Belongs to the 'phage' integrase family
LN246_11965	COG0037	tRNA processing
LN246_11970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LN246_11995	COG0109	protoheme IX farnesyltransferase activity
LN246_12000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LN246_12005	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LN246_12010	COG1007	ATP synthesis coupled electron transport
LN246_12020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LN246_12025	COG0713	ATP synthesis coupled electron transport
LN246_12030	COG0839	Belongs to the complex I subunit 6 family
LN246_12035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LN246_12040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LN246_12065	COG0649	NAD binding
LN246_12070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LN246_12075	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LN246_12080	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LN246_12090	COG1222	aaa ATPase
LN246_12095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LN246_12095	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LN246_12105	COG2853	Lipoprotein
LN246_12130	COG0492	ferredoxin-NADP+ reductase activity
LN246_12140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LN246_12160	COG0318	PFAM AMP-dependent synthetase and ligase
LN246_12170	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LN246_12195	COG0358	DNA primase activity
LN246_12205	COG0328	RNA-DNA hybrid ribonuclease activity
LN246_12210	COG0571	ribonuclease III activity
LN246_12215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LN246_12225	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LN246_12230	COG0514	ATP-dependent DNA helicase (RecQ)
LN246_12270	COG0745	RESPONSE REGULATOR receiver
LN246_12280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LN246_12285	COG0581	inorganic phosphate transmembrane transporter activity
LN246_12290	COG0573	inorganic phosphate transmembrane transporter activity
LN246_12295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LN246_12300	COG0745	RESPONSE REGULATOR receiver
LN246_12305	COG0306	phosphate transporter
LN246_12330	COG0848	biopolymer transport protein
LN246_12335	COG0811	peptide transport
LN246_12340	COG0811	peptide transport
LN246_12365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LN246_12370	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LN246_12385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LN246_12400	COG0203	ribosomal protein L17
LN246_12405	COG0202	RNA polymerase activity
LN246_12410	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LN246_12415	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LN246_12420	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LN246_12425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LN246_12435	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LN246_12440	COG0024	Methionine aminopeptidase
LN246_12445	COG0201	protein transport
LN246_12450	COG0200	Binds to the 23S rRNA
LN246_12455	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LN246_12460	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LN246_12465	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LN246_12470	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LN246_12475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LN246_12480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LN246_12485	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LN246_12490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LN246_12495	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LN246_12500	COG0255	Belongs to the universal ribosomal protein uL29 family
LN246_12505	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LN246_12510	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LN246_12515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LN246_12520	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LN246_12525	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LN246_12530	COG0089	rRNA binding
LN246_12535	COG0088	Forms part of the polypeptide exit tunnel
LN246_12540	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LN246_12545	COG0051	transcription antitermination factor activity, RNA binding
LN246_12595	COG0288	reversible hydration of carbon dioxide
LN246_12600	COG0659	secondary active sulfate transmembrane transporter activity
LN246_12630	COG1408	metallophosphoesterase
LN246_12640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LN246_12650	COG1451	nucleotide metabolic process
LN246_12660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LN246_12675	COG4932	domain protein
LN246_12675	COG5295	Hep Hag repeat protein
LN246_12710	COG0129	dihydroxy-acid dehydratase activity
LN246_12715	COG0791	NLP P60 protein
LN246_12715	COG1388	LysM domain
LN246_12735	COG2259	Doxx family
LN246_12750	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LN246_12755	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LN246_12765	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LN246_12770	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LN246_12775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LN246_12800	COG4115	mRNA cleavage
LN246_12830	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LN246_12840	COG0673	inositol 2-dehydrogenase activity
LN246_12855	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LN246_12860	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LN246_12875	COG1216	Glycosyl transferase, family 2
LN246_12895	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LN246_12900	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LN246_12920	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LN246_12925	COG0237	dephospho-CoA kinase activity
LN246_12940	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LN246_12950	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LN246_12960	COG0372	Belongs to the citrate synthase family
LN246_12965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LN246_12970	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LN246_12975	COG0564	pseudouridine synthase activity
LN246_12980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LN246_12990	COG0107	imidazoleglycerol-phosphate synthase activity
LN246_12995	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LN246_13000	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LN246_13005	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LN246_13005	COG0517	IMP dehydrogenase activity
LN246_13010	COG1187	pseudouridine synthase activity
LN246_13015	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LN246_13060	COG1115	amino acid carrier protein
LN246_13065	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LN246_13075	COG0011	TIGRFAM Protein of
LN246_13080	COG2081	HI0933 family
LN246_13090	COG1217	gtp-binding protein TYPA
LN246_13095	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LN246_13110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LN246_13115	COG0489	protein tyrosine kinase activity
LN246_13130	COG3746	phosphate-selective porin O and P
LN246_13165	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LN246_13170	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LN246_13180	COG0512	Glutamine amidotransferase of anthranilate synthase
LN246_13300	COG0165	Argininosuccinate lyase
LN246_13350	COG2239	Acts as a magnesium transporter
LN246_13355	COG2022	thiamine diphosphate biosynthetic process
LN246_13375	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LN246_13410	COG4771	TonB-dependent receptor
LN246_13415	COG0537	adenosine 5'-monophosphoramidase activity
LN246_13420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LN246_13425	COG0072	phenylalanine-tRNA ligase activity
LN246_13425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LN246_13430	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LN246_13435	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LN246_13440	COG0539	negative regulation of cytoplasmic translation
LN246_13440	COG1185	polyribonucleotide nucleotidyltransferase activity
LN246_13445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LN246_13465	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LN246_13470	COG0693	protein deglycase activity
LN246_13505	COG0039	L-malate dehydrogenase activity
LN246_13520	COG0114	fumarate hydratase activity
LN246_13525	COG0045	succinate-CoA ligase (ADP-forming) activity
LN246_13530	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LN246_13545	COG0674	pyruvate-flavodoxin oxidoreductase activity
LN246_13545	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LN246_13640	COG2197	response regulator
LN246_13645	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LN246_13650	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LN246_13690	COG0546	phosphoglycolate phosphatase activity
LN246_13695	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LN246_13700	COG1144	Oxidoreductase
LN246_13705	COG0674	pyruvate-flavodoxin oxidoreductase activity
LN246_13710	COG1013	pyruvate-flavodoxin oxidoreductase activity
LN246_13760	COG0445	tRNA wobble uridine modification
LN246_13800	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
LN246_13820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LN246_13825	COG2857	Cytochrome c1
LN246_13830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LN246_13835	COG0602	queuosine metabolic process
LN246_13865	COG0303	'Molybdopterin
LN246_13875	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LN246_13895	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LN246_13900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LN246_13920	COG1666	GTP binding
LN246_13940	COG0792	nuclease activity
LN246_13945	COG5285	phytanoyl-CoA dioxygenase
LN246_13960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LN246_13970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LN246_13970	COG0140	phosphoribosyl-ATP diphosphatase activity
LN246_13990	COG1012	belongs to the aldehyde dehydrogenase family
LN246_14005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LN246_14015	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LN246_14030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LN246_14035	COG0288	reversible hydration of carbon dioxide
LN246_14040	COG0439	Biotin carboxylase
LN246_14050	COG1136	(ABC) transporter
LN246_14055	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LN246_14070	COG0772	Belongs to the SEDS family
LN246_14075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LN246_14085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LN246_14095	COG0424	maF-like protein
LN246_14100	COG0156	8-amino-7-oxononanoate synthase activity
LN246_14120	COG0174	glutamine synthetase
LN246_14140	COG0752	glycyl-tRNA synthetase alpha subunit
LN246_14145	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LN246_14155	COG1519	Transferase
LN246_14165	COG0564	pseudouridine synthase activity
LN246_14175	COG0228	four-way junction DNA binding
LN246_14180	COG1837	Belongs to the UPF0109 family
LN246_14185	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LN246_14190	COG0336	Belongs to the RNA methyltransferase TrmD family
LN246_14195	COG0335	large ribosomal subunit rRNA binding
LN246_14235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LN246_14245	COG0564	pseudouridine synthase activity
LN246_14260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LN246_14265	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LN246_14270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LN246_14290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LN246_14320	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LN246_14325	COG1862	Preprotein translocase
LN246_14330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LN246_14335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LN246_14345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LN246_14350	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LN246_14355	COG2027	D-alanyl-D-alanine carboxypeptidase
LN246_14360	COG0436	Aminotransferase
LN246_14375	COG1193	negative regulation of DNA recombination
LN246_14380	COG1193	negative regulation of DNA recombination
LN246_14405	COG4974	Belongs to the 'phage' integrase family
LN246_14415	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LN246_14420	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LN246_14475	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LN246_14480	COG3259	Nickel-dependent hydrogenase
LN246_14495	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LN246_14500	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
LN246_14525	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LN246_14530	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LN246_14570	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LN246_14575	COG0298	carbon dioxide binding
LN246_14580	COG0409	Hydrogenase expression formation protein
LN246_14585	COG0309	Hydrogenase expression formation protein (HypE)
LN246_14590	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LN246_14590	COG1024	Enoyl-CoA hydratase
LN246_14600	COG0375	protein maturation
LN246_14620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LN246_14625	COG0629	single-stranded DNA binding
LN246_14630	COG0360	Binds together with S18 to 16S ribosomal RNA
LN246_14635	COG1466	dna polymerase III delta subunit
LN246_14640	COG0557	exoribonuclease II activity
LN246_14645	COG0557	exoribonuclease II activity
LN246_14650	COG0501	Belongs to the peptidase M48B family
LN246_14660	COG3292	Two component regulator propeller
LN246_14660	COG2205	protein histidine kinase activity
LN246_14660	COG0745	RESPONSE REGULATOR receiver
LN246_14665	COG5002	protein histidine kinase activity
LN246_14710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LN246_14780	COG2861	carbohydrate metabolic process
LN246_14830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LN246_14835	COG1136	(ABC) transporter
LN246_14835	COG0577	efflux transmembrane transporter activity
LN246_14840	COG0577	efflux transmembrane transporter activity
LN246_14840	COG1136	(ABC) transporter
LN246_14845	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LN246_14855	COG3850	Histidine kinase
LN246_14855	COG5002	protein histidine kinase activity
LN246_14870	COG0791	NLP P60 protein
LN246_14890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LN246_14895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LN246_14900	COG0494	nUDIX hydrolase
LN246_14905	COG0527	aspartate kinase activity
LN246_14925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LN246_14945	COG0196	riboflavin kinase activity
LN246_14950	COG1073	alpha beta
LN246_14960	COG2226	methyltransferase
LN246_14965	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LN246_14970	COG0642	Histidine kinase
LN246_14975	COG0745	RESPONSE REGULATOR receiver
LN246_14985	COG2207	Transcriptional regulator
LN246_14985	COG4753	response regulator
LN246_14990	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LN246_15000	COG4772	TonB-dependent receptor
LN246_15015	COG3901	Regulator of nitric oxide reductase transcription
LN246_15015	COG0348	domain, Protein
LN246_15020	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
LN246_15030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LN246_15040	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LN246_15090	COG1393	Belongs to the ArsC family
LN246_15095	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LN246_15115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LN246_15130	COG5002	protein histidine kinase activity
LN246_15130	COG3850	Histidine kinase
LN246_15170	COG0281	malic enzyme
LN246_15170	COG0280	phosphate acetyltransferase
LN246_15185	COG0745	RESPONSE REGULATOR receiver
LN246_15190	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LN246_15190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity