locus-tag	class	description
K7887_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K7887_00010	COG0592	DNA-directed DNA polymerase activity
K7887_00015	COG2501	S4 domain
K7887_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K7887_00030	COG0187	DNA topoisomerase II activity
K7887_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K7887_00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K7887_00075	COG0516	GMP reductase activity
K7887_00075	COG0517	IMP dehydrogenase activity
K7887_00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
K7887_00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K7887_00105	COG1428	Deoxynucleoside kinase
K7887_00110	COG1428	Deoxynucleoside kinase
K7887_00115	COG1388	LysM domain
K7887_00115	COG3858	chitin binding
K7887_00120	COG1335	isochorismatase
K7887_00125	COG0590	tRNA wobble adenosine to inosine editing
K7887_00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K7887_00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K7887_00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K7887_00190	COG1982	Orn Lys Arg decarboxylase major
K7887_00200	COG3870	Protein conserved in bacteria
K7887_00205	COG1728	Protein conserved in bacteria
K7887_00210	COG0470	DNA polymerase III
K7887_00215	COG1774	PSP1 C-terminal conserved region
K7887_00220	COG4467	Involved in initiation control of chromosome replication
K7887_00225	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K7887_00230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K7887_00235	COG2002	toxin-antitoxin pair type II binding
K7887_00245	COG0084	hydrolase, TatD family'
K7887_00250	COG3583	domain protein
K7887_00250	COG3584	3D domain protein
K7887_00260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K7887_00270	COG4466	Protein conserved in bacteria
K7887_00280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K7887_00285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K7887_00290	COG0251	oxidation-reduction process
K7887_00300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K7887_00310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K7887_00325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K7887_00330	COG2002	toxin-antitoxin pair type II binding
K7887_00335	COG2244	polysaccharide biosynthetic process
K7887_00340	COG3956	TIGRFAM MazG family protein
K7887_00345	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K7887_00365	COG1098	S1 RNA binding domain
K7887_00380	COG2208	phosphoserine phosphatase activity
K7887_00390	COG2304	oxidoreductase activity
K7887_00395	COG0515	serine threonine protein kinase
K7887_00405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K7887_00410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K7887_00415	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K7887_00420	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K7887_00425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K7887_00430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K7887_00435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K7887_00440	COG0512	Glutamine amidotransferase of anthranilate synthase
K7887_00445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K7887_00450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K7887_00455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K7887_00460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K7887_00465	COG1396	sequence-specific DNA binding
K7887_00470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K7887_00475	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K7887_00560	COG3880	PFAM UvrB UvrC protein
K7887_00565	COG3869	Catalyzes the specific phosphorylation of arginine residues in
K7887_00570	COG0542	response to heat
K7887_00575	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K7887_00580	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
K7887_00585	COG4956	integral membrane protein (PIN domain superfamily)
K7887_00590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K7887_00595	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K7887_00605	COG1045	serine acetyltransferase
K7887_00610	COG0215	cysteine-tRNA ligase activity
K7887_00620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K7887_00625	COG3688	RNA-binding protein containing a PIN domain
K7887_00635	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K7887_00640	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K7887_00645	COG0250	Participates in transcription elongation, termination and antitermination
K7887_00650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K7887_00655	COG0081	regulation of translation
K7887_00660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K7887_00665	COG0222	ribosome binding
K7887_00670	COG2813	Specifically methylates the guanine in position
K7887_00675	COG0085	RNA polymerase activity
K7887_00680	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K7887_00685	COG1358	cellular component organization or biogenesis
K7887_00690	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K7887_00695	COG0049	tRNA binding
K7887_00700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K7887_00705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K7887_00710	COG0051	transcription antitermination factor activity, RNA binding
K7887_00715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K7887_00720	COG0088	Forms part of the polypeptide exit tunnel
K7887_00725	COG0089	rRNA binding
K7887_00730	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K7887_00735	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K7887_00740	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K7887_00745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K7887_00750	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K7887_00755	COG0255	Belongs to the universal ribosomal protein uL29 family
K7887_00760	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K7887_00765	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K7887_00770	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K7887_00780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K7887_00785	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K7887_00790	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K7887_00800	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K7887_00805	COG1841	ribosomal large subunit assembly
K7887_00810	COG0200	Binds to the 23S rRNA
K7887_00815	COG0201	protein transport
K7887_00820	COG0563	adenylate kinase activity
K7887_00825	COG0024	Methionine aminopeptidase
K7887_00830	COG2163	COG2163 Ribosomal protein L14E L6E L27E
K7887_00835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K7887_00840	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K7887_00845	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K7887_00860	COG0203	ribosomal protein L17
K7887_00865	COG1122	ATPase activity
K7887_00870	COG1122	ATPase activity
K7887_00875	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K7887_00880	COG0101	tRNA pseudouridine synthase activity
K7887_00885	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K7887_00890	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K7887_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
K7887_00920	COG0489	protein tyrosine kinase activity
K7887_00930	COG2194	sulfuric ester hydrolase activity
K7887_00935	COG0726	polysaccharide deacetylase
K7887_01010	COG1595	DNA-templated transcription, initiation
K7887_01015	COG5662	AntiSigma factor
K7887_01020	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K7887_01025	COG4856	YbbR-like protein
K7887_01030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K7887_01040	COG1114	Component of the transport system for branched-chain amino acids
K7887_01045	COG1802	Transcriptional regulator
K7887_01055	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K7887_01075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K7887_01080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K7887_01085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K7887_01130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K7887_01135	COG0840	transmembrane signaling receptor activity
K7887_01150	COG5577	PFAM Coat F domain
K7887_01160	COG0393	Putative heavy-metal-binding
K7887_01165	COG1649	PFAM Uncharacterised BCR, COG1649
K7887_01170	COG0789	Transcriptional regulator
K7887_01175	COG1253	flavin adenine dinucleotide binding
K7887_01180	COG4536	flavin adenine dinucleotide binding
K7887_01185	COG0772	Belongs to the SEDS family
K7887_01215	COG1695	Transcriptional regulator
K7887_01225	COG4585	Histidine kinase
K7887_01240	COG1131	(ABC) transporter
K7887_01255	COG1476	TRANSCRIPTIONal
K7887_01265	COG0840	transmembrane signaling receptor activity
K7887_01270	COG1595	DNA-templated transcription, initiation
K7887_01280	COG3942	CHAP domain
K7887_01280	COG1388	LysM domain
K7887_01290	COG1410	methionine synthase
K7887_01290	COG0646	methionine synthase
K7887_01295	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K7887_01295	COG0646	methionine synthase
K7887_01300	COG0626	cystathionine gamma-synthase activity
K7887_01305	COG0626	cystathionine gamma-synthase activity
K7887_01310	COG4988	ABC transporter
K7887_01315	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K7887_01325	COG3212	peptidase
K7887_01330	COG3850	Histidine kinase
K7887_01330	COG5002	protein histidine kinase activity
K7887_01335	COG0745	RESPONSE REGULATOR receiver
K7887_01340	COG1132	(ABC) transporter
K7887_01350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K7887_01350	COG0723	plastoquinol--plastocyanin reductase activity
K7887_01360	COG1227	inorganic diphosphatase activity
K7887_01365	COG4134	Bacterial extracellular solute-binding protein
K7887_01380	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K7887_01385	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K7887_01385	COG1213	nucleotidyl transferase
K7887_01400	COG3237	CsbD-like
K7887_01410	COG1028	Short-chain dehydrogenase reductase Sdr
K7887_01430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K7887_01435	COG3973	AAA domain
K7887_01445	COG1937	Protein conserved in bacteria
K7887_01450	COG2608	mercury ion transmembrane transporter activity
K7887_01455	COG2217	Heavy metal translocating P-type atpase
K7887_01465	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K7887_01480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K7887_01485	COG0513	Belongs to the DEAD box helicase family
K7887_01490	COG4294	response to UV
K7887_01495	COG3402	PFAM membrane-flanked domain
K7887_01500	COG3428	Bacterial PH domain
K7887_01505	COG0705	Rhomboid family
K7887_01510	COG0736	holo-[acyl-carrier-protein] synthase activity
K7887_01515	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K7887_01525	COG0864	Transcriptional regulator
K7887_01530	COG2337	Toxic component of a toxin-antitoxin (TA) module
K7887_01535	COG1366	Belongs to the anti-sigma-factor antagonist family
K7887_01540	COG1366	Belongs to the anti-sigma-factor antagonist family
K7887_01545	COG2172	sigma factor antagonist activity
K7887_01550	COG2208	phosphoserine phosphatase activity
K7887_01555	COG1366	Belongs to the anti-sigma-factor antagonist family
K7887_01560	COG2172	sigma factor antagonist activity
K7887_01565	COG1191	sigma factor activity
K7887_01570	COG2208	phosphoserine phosphatase activity
K7887_01575	COG2183	response to ionizing radiation
K7887_01585	COG3091	SprT-like family
K7887_01675	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K7887_01680	COG0802	atpase or kinase
K7887_01685	COG1214	PFAM Peptidase M22, glycoprotease
K7887_01690	COG0456	acetyltransferase
K7887_01705	COG1131	(ABC) transporter
K7887_01720	COG0488	(ABC) transporter
K7887_01725	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K7887_01730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K7887_01735	COG0805	protein transport
K7887_01745	COG1266	CAAX protease self-immunity
K7887_01755	COG0459	protein refolding
K7887_01825	COG0300	oxidoreductase activity
K7887_01830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K7887_01835	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
K7887_01840	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K7887_01845	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K7887_01855	COG1733	regulation of RNA biosynthetic process
K7887_01865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7887_01880	COG0598	Magnesium transport protein CorA
K7887_01905	COG2182	Extracellular solute-binding protein
K7887_01910	COG1609	Transcriptional regulator
K7887_01920	COG5002	protein histidine kinase activity
K7887_01925	COG0745	RESPONSE REGULATOR receiver
K7887_01930	COG0577	efflux transmembrane transporter activity
K7887_01935	COG1136	(ABC) transporter
K7887_01940	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K7887_01945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K7887_01955	COG1278	Cold shock
K7887_01960	COG1329	Transcriptional regulator
K7887_01965	COG0745	RESPONSE REGULATOR receiver
K7887_01970	COG5002	protein histidine kinase activity
K7887_01970	COG3850	Histidine kinase
K7887_01975	COG1136	(ABC) transporter
K7887_01980	COG1136	(ABC) transporter
K7887_01980	COG0577	efflux transmembrane transporter activity
K7887_01990	COG2172	sigma factor antagonist activity
K7887_02000	COG0714	Associated with various cellular activities
K7887_02005	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
K7887_02010	COG1305	Transglutaminase-like
K7887_02015	COG0519	Catalyzes the synthesis of GMP from XMP
K7887_02015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K7887_02020	COG2252	PERMEase
K7887_02045	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K7887_02050	COG1131	(ABC) transporter
K7887_02055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K7887_02070	COG1595	DNA-templated transcription, initiation
K7887_02080	COG2814	Major facilitator Superfamily
K7887_02085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K7887_02090	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
K7887_02100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K7887_02105	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K7887_02110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K7887_02115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K7887_02120	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K7887_02125	COG0047	phosphoribosylformylglycinamidine synthase activity
K7887_02130	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K7887_02135	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K7887_02145	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K7887_02155	COG0151	Belongs to the GarS family
K7887_02165	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K7887_02170	COG1470	cell adhesion involved in biofilm formation
K7887_02175	COG4496	protein, YerC YecD
K7887_02190	COG0210	DNA helicase
K7887_02200	COG4851	CamS sex pheromone cAM373 precursor
K7887_02215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K7887_02220	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K7887_02225	COG0154	amidase activity
K7887_02235	COG1876	peptidase activity
K7887_02240	COG1585	Membrane protein implicated in regulation of membrane protease activity
K7887_02245	COG2268	Band 7 protein
K7887_02250	COG1597	lipid kinase activity
K7887_02265	COG0175	sulfate reduction
K7887_02270	COG0306	phosphate transporter
K7887_02275	COG2046	Belongs to the sulfate adenylyltransferase family
K7887_02280	COG0529	Catalyzes the synthesis of activated sulfate
K7887_02285	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K7887_02310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K7887_02315	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K7887_02320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K7887_02330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K7887_02340	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K7887_02345	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
K7887_02355	COG1349	DNA-binding transcription factor activity
K7887_02370	COG0561	phosphatase activity
K7887_02410	COG2233	PERMEase
K7887_02420	COG0583	DNA-binding transcription factor activity
K7887_02450	COG1366	Belongs to the anti-sigma-factor antagonist family
K7887_02465	COG2207	Transcriptional regulator
K7887_02465	COG3708	Transcriptional regulator
K7887_02520	COG1028	Short-chain dehydrogenase reductase Sdr
K7887_02525	COG0456	acetyltransferase
K7887_02525	COG1846	Transcriptional regulator
K7887_02535	COG0601	transmembrane transport
K7887_02575	COG3546	catalase activity
K7887_02580	COG1263	PTS System
K7887_02580	COG2190	(PTS) system
K7887_02580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K7887_02600	COG0655	NAD(P)H dehydrogenase (quinone) activity
K7887_02615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K7887_02625	COG1113	amino acid transport
K7887_02630	COG2814	Major facilitator Superfamily
K7887_02640	COG1280	lysine exporter protein (LysE YggA)
K7887_02650	COG1834	amidinotransferase
K7887_02660	COG0778	Nitroreductase
K7887_02680	COG1247	-acetyltransferase
K7887_02700	COG3655	Transcriptional regulator
K7887_02725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K7887_02740	COG2814	Major facilitator Superfamily
K7887_02750	COG3973	AAA domain
K7887_02765	COG1595	DNA-templated transcription, initiation
K7887_02770	COG1247	-acetyltransferase
K7887_02790	COG2226	methyltransferase
K7887_02795	COG2124	cytochrome p450
K7887_02850	COG2226	methyltransferase
K7887_02870	COG1404	Belongs to the peptidase S8 family
K7887_02900	COG0785	Cytochrome C biogenesis protein
K7887_02905	COG0745	RESPONSE REGULATOR receiver
K7887_02920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7887_02930	COG2318	DinB family
K7887_02935	COG1794	racemase activity, acting on amino acids and derivatives
K7887_02955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K7887_02960	COG1063	alcohol dehydrogenase
K7887_02985	COG1476	TRANSCRIPTIONal
K7887_03015	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K7887_03015	COG0456	acetyltransferase
K7887_03045	COG2267	carboxylic ester hydrolase activity
K7887_03090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7887_03240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K7887_03265	COG5444	nuclease activity
K7887_03275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K7887_03285	COG2356	endonuclease I
K7887_03325	COG1785	Belongs to the alkaline phosphatase family
K7887_03350	COG0456	acetyltransferase
K7887_03355	COG1522	sequence-specific DNA binding
K7887_03385	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K7887_03390	COG2376	Dihydroxyacetone kinase
K7887_03405	COG1349	DNA-binding transcription factor activity
K7887_03410	COG0698	ribose 5-phosphate isomerase
K7887_03415	COG1494	fructose-1,6-bisphosphatase
K7887_03420	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K7887_03425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K7887_03465	COG1266	CAAX protease self-immunity
K7887_03470	COG0789	Transcriptional regulator
K7887_03495	COG0772	Belongs to the SEDS family
K7887_03520	COG1268	BioY protein
K7887_03530	COG0300	oxidoreductase activity
K7887_03540	COG1595	DNA-templated transcription, initiation
K7887_03550	COG1595	DNA-templated transcription, initiation
K7887_03560	COG3173	Aminoglycoside phosphotransferase
K7887_03600	COG1607	acyl-coa hydrolase
K7887_03605	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K7887_03610	COG1132	(ABC) transporter
K7887_03615	COG1309	transcriptional regulator
K7887_03625	COG0628	permease
K7887_03645	COG1366	Belongs to the anti-sigma-factor antagonist family
K7887_03660	COG0681	Belongs to the peptidase S26 family
K7887_03665	COG3227	Zinc metalloprotease (Elastase)
K7887_03680	COG0745	RESPONSE REGULATOR receiver
K7887_03685	COG3850	Histidine kinase
K7887_03685	COG5002	protein histidine kinase activity
K7887_03700	COG1309	transcriptional regulator
K7887_03705	COG2814	Major facilitator Superfamily
K7887_03710	COG2329	Antibiotic biosynthesis monooxygenase
K7887_03725	COG0322	excinuclease ABC activity
K7887_03745	COG3290	protein histidine kinase activity
K7887_03750	COG3279	Response regulator of the LytR AlgR family
K7887_03755	COG4555	ABC transporter
K7887_03760	COG1668	transmembrane transport
K7887_03770	COG3711	transcriptional antiterminator
K7887_03790	COG2186	Transcriptional regulator
K7887_03800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K7887_03810	COG0508	dehydrogenase complex catalyzes the overall conversion of
K7887_03835	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K7887_03840	COG1183	phosphatidylcholine synthase activity
K7887_03850	COG1960	acyl-CoA dehydrogenase activity
K7887_03855	COG1966	Carbon starvation protein
K7887_03860	COG3852	Histidine kinase
K7887_03865	COG0166	Belongs to the GPI family
K7887_03870	COG1012	belongs to the aldehyde dehydrogenase family
K7887_03875	COG2814	Major facilitator Superfamily
K7887_03880	COG4895	conserved protein (DUF2196)
K7887_03890	COG2368	4-hydroxyphenylacetate
K7887_03895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K7887_03905	COG0154	amidase activity
K7887_03910	COG1132	(ABC) transporter
K7887_03915	COG1132	(ABC) transporter
K7887_03920	COG1115	amino acid carrier protein
K7887_03925	COG2200	EAL domain
K7887_03935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K7887_03935	COG0723	plastoquinol--plastocyanin reductase activity
K7887_03940	COG0513	Belongs to the DEAD box helicase family
K7887_03945	COG2124	cytochrome p450
K7887_03955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K7887_03960	COG0791	NLP P60 protein
K7887_03960	COG3883	PFAM NLP P60 protein
K7887_03975	COG2244	polysaccharide biosynthetic process
K7887_03980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K7887_03985	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
K7887_03990	COG1077	Cell shape determining protein MreB Mrl
K7887_04030	COG0745	RESPONSE REGULATOR receiver
K7887_04035	COG5002	protein histidine kinase activity
K7887_04040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K7887_04050	COG1988	membrane-bound metal-dependent
K7887_04060	COG4840	Belongs to the UPF0435 family
K7887_04070	COG1295	ribonuclease BN
K7887_04075	COG2217	Heavy metal translocating P-type atpase
K7887_04095	COG0477	Major facilitator Superfamily
K7887_04105	COG0024	Methionine aminopeptidase
K7887_04120	COG1737	Transcriptional regulator
K7887_04135	COG1175	transmembrane transport
K7887_04140	COG0395	ABC-type sugar transport system, permease component
K7887_04145	COG3842	ATPase activity
K7887_04155	COG3876	Protein conserved in bacteria
K7887_04160	COG1472	Belongs to the glycosyl hydrolase 3 family
K7887_04165	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K7887_04175	COG0247	lactate metabolic process
K7887_04180	COG0277	FAD linked oxidase domain protein
K7887_04185	COG3835	regulator
K7887_04195	COG0387	Pfam Sodium calcium exchanger
K7887_04200	COG2364	Membrane
K7887_04215	COG0535	radical SAM domain protein
K7887_04240	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K7887_04245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K7887_04250	COG4807	Protein conserved in bacteria
K7887_04255	COG0673	inositol 2-dehydrogenase activity
K7887_04270	COG4213	ABC transporter substrate-binding protein
K7887_04280	COG4214	carbohydrate transport
K7887_04290	COG2972	Histidine kinase
K7887_04295	COG2197	response regulator
K7887_04300	COG4213	ABC transporter substrate-binding protein
K7887_04305	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K7887_04310	COG0697	spore germination
K7887_04315	COG3239	Fatty acid desaturase
K7887_04360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K7887_04365	COG2234	aminopeptidase activity
K7887_04405	COG3119	arylsulfatase activity
K7887_04410	COG1280	lysine exporter protein (LysE YggA)
K7887_04435	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K7887_04445	COG3773	Cell wall hydrolase
K7887_04495	COG0697	spore germination
K7887_04520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K7887_04525	COG0398	Pfam SNARE associated Golgi protein
K7887_04540	COG1657	PFAM Prenyltransferase squalene oxidase
K7887_04550	COG0745	RESPONSE REGULATOR receiver
K7887_04555	COG5002	protein histidine kinase activity
K7887_04610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K7887_04645	COG1388	LysM domain
K7887_04645	COG0791	NLP P60 protein
K7887_04655	COG4533	DNA binding
K7887_04700	COG1388	LysM domain
K7887_04705	COG0745	RESPONSE REGULATOR receiver
K7887_04710	COG5002	protein histidine kinase activity
K7887_04720	COG1404	Belongs to the peptidase S8 family
K7887_04795	COG1595	DNA-templated transcription, initiation
K7887_04800	COG3711	transcriptional antiterminator
K7887_04805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K7887_04805	COG2190	(PTS) system
K7887_04805	COG1263	PTS System
K7887_04815	COG1929	Belongs to the glycerate kinase type-1 family
K7887_04820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K7887_04830	COG3835	regulator
K7887_04835	COG0737	Belongs to the 5'-nucleotidase family
K7887_04840	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K7887_04850	COG0697	spore germination
K7887_04860	COG3069	C4-dicarboxylate transmembrane transporter activity
K7887_04880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K7887_04900	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K7887_04905	COG2208	phosphoserine phosphatase activity
K7887_04910	COG3403	YqcI/YcgG family
K7887_04915	COG4191	Histidine kinase
K7887_04920	COG1757	Na H antiporter
K7887_04925	COG1070	Carbohydrate kinase
K7887_04940	COG3344	reverse transcriptase
K7887_04965	COG1090	epimerase
K7887_04970	COG2137	regulation of response to DNA damage stimulus
K7887_04975	COG0300	oxidoreductase activity
K7887_05000	COG1988	membrane-bound metal-dependent
K7887_05010	COG1194	a g-specific adenine glycosylase
K7887_05020	COG1028	Short-chain dehydrogenase reductase Sdr
K7887_05035	COG3557	Belongs to the UPF0374 family
K7887_05040	COG1132	(ABC) transporter
K7887_05045	COG4129	membrane
K7887_05050	COG0067	glutamate synthase
K7887_05050	COG0069	glutamate synthase activity
K7887_05050	COG0070	glutamate synthase
K7887_05055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K7887_05060	COG4555	ABC transporter
K7887_05085	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K7887_05090	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K7887_05095	COG2096	Adenosyltransferase
K7887_05100	COG0735	belongs to the Fur family
K7887_05220	COG3382	B3 4 domain protein
K7887_05240	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K7887_05245	COG2766	serine protein kinase
K7887_05265	COG3279	Response regulator of the LytR AlgR family
K7887_05270	COG2972	Histidine kinase
K7887_05275	COG4608	Belongs to the ABC transporter superfamily
K7887_05280	COG0444	Belongs to the ABC transporter superfamily
K7887_05285	COG0601	transmembrane transport
K7887_05290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7887_05300	COG0747	negative chemotaxis
K7887_05305	COG0402	S-adenosylhomocysteine deaminase activity
K7887_05310	COG0402	S-adenosylhomocysteine deaminase activity
K7887_05320	COG2205	protein histidine kinase activity
K7887_05330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7887_05335	COG0601	transmembrane transport
K7887_05340	COG0444	Belongs to the ABC transporter superfamily
K7887_05345	COG4608	Belongs to the ABC transporter superfamily
K7887_05350	COG0747	negative chemotaxis
K7887_05355	COG0601	transmembrane transport
K7887_05360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7887_05365	COG0444	Belongs to the ABC transporter superfamily
K7887_05370	COG4608	Belongs to the ABC transporter superfamily
K7887_05380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K7887_05395	COG1115	amino acid carrier protein
K7887_05415	COG2514	catechol 2,3-dioxygenase activity
K7887_05445	COG0346	lactoylglutathione lyase activity
K7887_05450	COG1253	flavin adenine dinucleotide binding
K7887_05460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K7887_05465	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K7887_05465	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K7887_05475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K7887_05480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K7887_05485	COG2205	protein histidine kinase activity
K7887_05495	COG0789	Transcriptional regulator
K7887_05510	COG0655	NAD(P)H dehydrogenase (quinone) activity
K7887_05520	COG0656	L-ascorbic acid biosynthetic process
K7887_05530	COG0456	acetyltransferase
K7887_05535	COG0564	pseudouridine synthase activity
K7887_05550	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K7887_05555	COG0366	Alpha amylase catalytic
K7887_05560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K7887_05560	COG3153	acetyltransferase
K7887_05570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K7887_05580	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K7887_05585	COG1501	Belongs to the glycosyl hydrolase 31 family
K7887_05595	COG2188	Transcriptional regulator
K7887_05600	COG1012	belongs to the aldehyde dehydrogenase family
K7887_05610	COG1653	transport
K7887_05615	COG1175	transmembrane transport
K7887_05620	COG0395	ABC-type sugar transport system, permease component
K7887_05625	COG2188	Transcriptional regulator
K7887_05630	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
K7887_05635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K7887_05640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K7887_05645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K7887_05650	COG2203	Gaf domain
K7887_05650	COG4585	Histidine kinase
K7887_05655	COG2197	response regulator
K7887_05660	COG0431	NADPH-dependent FMN reductase
K7887_05675	COG2866	Carboxypeptidase
K7887_05680	COG2239	Acts as a magnesium transporter
K7887_05685	COG0730	response to heat
K7887_05690	COG2719	SpoVR family
K7887_05700	COG1349	DNA-binding transcription factor activity
K7887_05705	COG1105	Belongs to the carbohydrate kinase PfkB family
K7887_05710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K7887_05710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K7887_05710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K7887_05720	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
K7887_05730	COG1695	Transcriptional regulator
K7887_05740	COG2112	serine threonine protein kinase
K7887_05760	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K7887_05770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K7887_05775	COG0569	domain protein
K7887_05780	COG0398	Pfam SNARE associated Golgi protein
K7887_05805	COG0582	viral genome integration into host DNA
K7887_05830	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K7887_05865	COG0586	Pfam SNARE associated Golgi protein
K7887_05875	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K7887_05880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K7887_05885	COG1366	Belongs to the anti-sigma-factor antagonist family
K7887_05890	COG4989	oxidoreductase activity
K7887_05900	COG1301	dicarboxylic acid transport
K7887_05915	COG1309	transcriptional regulator
K7887_05930	COG0589	response to stress
K7887_05935	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K7887_05940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K7887_05950	COG1028	Short-chain dehydrogenase reductase Sdr
K7887_05955	COG2814	Major facilitator Superfamily
K7887_05960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K7887_05965	COG4721	ABC-type cobalt transport system, permease component
K7887_05970	COG1122	ATPase activity
K7887_05980	COG0352	thiamine-phosphate diphosphorylase activity
K7887_05985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K7887_05990	COG2104	thiamine diphosphate biosynthetic process
K7887_05995	COG2022	thiamine diphosphate biosynthetic process
K7887_06000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K7887_06005	COG0351	phosphomethylpyrimidine kinase
K7887_06020	COG1278	Cold shock
K7887_06025	COG1132	(ABC) transporter
K7887_06030	COG1132	(ABC) transporter
K7887_06035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7887_06040	COG0765	amino acid transport
K7887_06045	COG1126	abc transporter atp-binding protein
K7887_06065	COG3842	ATPase activity
K7887_06070	COG2508	Transcriptional regulator
K7887_06090	COG0189	ligase activity
K7887_06100	COG0189	ligase activity
K7887_06110	COG3679	Belongs to the UPF0342 family
K7887_06115	COG0561	phosphatase activity
K7887_06120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K7887_06130	COG1024	Enoyl-CoA hydratase
K7887_06145	COG4152	abc transporter atp-binding protein
K7887_06150	COG1668	transmembrane transport
K7887_06155	COG0420	3'-5' exonuclease activity
K7887_06160	COG4717	serine-type aminopeptidase activity
K7887_06165	COG2814	Major facilitator Superfamily
K7887_06170	COG3481	metal-dependent phosphohydrolase, HD sub domain
K7887_06180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K7887_06210	COG1846	Transcriptional regulator
K7887_06230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K7887_06240	COG0537	adenosine 5'-monophosphoramidase activity
K7887_06245	COG1131	(ABC) transporter
K7887_06250	COG4473	ABC transporter
K7887_06260	COG1473	amidohydrolase
K7887_06275	COG4585	Histidine kinase
K7887_06280	COG2197	response regulator
K7887_06285	COG2329	Antibiotic biosynthesis monooxygenase
K7887_06290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K7887_06295	COG4191	Histidine kinase
K7887_06300	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K7887_06305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K7887_06310	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K7887_06315	COG1309	transcriptional regulator
K7887_06320	COG1511	domain protein
K7887_06325	COG1609	Transcriptional regulator
K7887_06335	COG1234	tRNA 3'-trailer cleavage
K7887_06340	COG0095	Lipoate-protein ligase
K7887_06345	COG0318	PFAM AMP-dependent synthetase and ligase
K7887_06350	COG1024	Enoyl-CoA hydratase
K7887_06365	COG0501	Belongs to the peptidase M48B family
K7887_06370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K7887_06375	COG2224	Isocitrate lyase
K7887_06385	COG4903	ComK protein
K7887_06390	COG2323	membrane
K7887_06400	COG0823	Involved in the tonB-independent uptake of proteins
K7887_06400	COG1506	peptidase
K7887_06400	COG4946	Tricorn protease homolog
K7887_06410	COG0398	Pfam SNARE associated Golgi protein
K7887_06420	COG1028	Short-chain dehydrogenase reductase Sdr
K7887_06435	COG0706	membrane insertase activity
K7887_06440	COG2814	Major facilitator Superfamily
K7887_06445	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K7887_06450	COG1074	ATP-dependent DNA helicase activity
K7887_06455	COG0420	3'-5' exonuclease activity
K7887_06460	COG0419	ATPase involved in DNA repair
K7887_06465	COG1403	HNH endonuclease
K7887_06500	COG2311	Membrane
K7887_06510	COG0179	Fumarylacetoacetate (FAA) hydrolase
K7887_06515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K7887_06525	COG3300	MHYT domain
K7887_06525	COG5001	Diguanylate cyclase
K7887_06535	COG0367	asparagine synthase
K7887_06550	COG1562	ergosterol biosynthetic process
K7887_06555	COG1233	COG1233 Phytoene dehydrogenase and related
K7887_06560	COG1215	transferase activity, transferring glycosyl groups
K7887_06575	COG0004	ammonium transporteR
K7887_06580	COG0347	Belongs to the P(II) protein family
K7887_06585	COG0534	Mate efflux family protein
K7887_06590	COG1917	Cupin 2, conserved barrel domain protein
K7887_06590	COG2207	Transcriptional regulator
K7887_06600	COG2182	Extracellular solute-binding protein
K7887_06605	COG1175	transmembrane transport
K7887_06610	COG3833	ABC-type maltose transport systems, permease component
K7887_06615	COG0366	Alpha amylase catalytic
K7887_06615	COG1874	Beta-galactosidase
K7887_06625	COG1028	Short-chain dehydrogenase reductase Sdr
K7887_06630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K7887_06635	COG1666	GTP binding
K7887_06640	COG2996	Protein conserved in bacteria
K7887_06650	COG1307	EDD domain protein, DegV family
K7887_06655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K7887_06670	COG0561	phosphatase activity
K7887_06675	COG1073	alpha beta
K7887_06680	COG2151	metal-sulfur cluster biosynthetic enzyme
K7887_06695	COG0542	response to heat
K7887_06710	COG2267	carboxylic ester hydrolase activity
K7887_06720	COG1744	ABC transporter substrate-binding protein PnrA-like
K7887_06735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K7887_06740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K7887_06745	COG5504	Zn-dependent protease
K7887_06750	COG0444	Belongs to the ABC transporter superfamily
K7887_06755	COG4608	Belongs to the ABC transporter superfamily
K7887_06765	COG0601	transmembrane transport
K7887_06770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7887_06785	COG0180	Tryptophanyl-tRNA synthetase
K7887_06795	COG4166	transmembrane transport
K7887_06800	COG0601	transmembrane transport
K7887_06805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7887_06810	COG0444	Belongs to the ABC transporter superfamily
K7887_06815	COG4608	Belongs to the ABC transporter superfamily
K7887_06835	COG0456	acetyltransferase
K7887_06845	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7887_06850	COG4605	iron ion homeostasis
K7887_06855	COG4604	ABC transporter, ATP-binding protein
K7887_06860	COG4607	ABC-type enterochelin transport system periplasmic component
K7887_06880	COG1393	Belongs to the ArsC family
K7887_06885	COG0861	Integral membrane protein TerC family
K7887_06890	COG4862	establishment of competence for transformation
K7887_06895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K7887_06905	COG1164	Oligoendopeptidase f
K7887_06915	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K7887_06920	COG2346	COG2346, Truncated hemoglobins
K7887_06925	COG0741	lytic transglycosylase activity
K7887_06930	COG4116	CYTH
K7887_06940	COG2357	RelA SpoT domain protein
K7887_06950	COG0564	pseudouridine synthase activity
K7887_06955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K7887_06960	COG0475	glutathione-regulated potassium exporter activity
K7887_06960	COG0589	response to stress
K7887_06965	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K7887_06995	COG0438	transferase activity, transferring glycosyl groups
K7887_07005	COG0438	transferase activity, transferring glycosyl groups
K7887_07010	COG1215	transferase activity, transferring glycosyl groups
K7887_07065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K7887_07080	COG2323	membrane
K7887_07110	COG0210	DNA helicase
K7887_07125	COG2323	membrane
K7887_07130	COG2153	protein acetylation
K7887_07135	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
K7887_07140	COG2382	esterase
K7887_07160	COG1999	signal sequence binding
K7887_07170	COG1418	mRNA catabolic process
K7887_07230	COG1363	Peptidase, m42
K7887_07235	COG1533	DNA photolyase activity
K7887_07245	COG2720	vancomycin resistance protein
K7887_07255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K7887_07260	COG4106	trans-aconitate 2-methyltransferase activity
K7887_07265	COG1388	LysM domain
K7887_07265	COG3584	3D domain protein
K7887_07275	COG0671	phosphoesterase, PA-phosphatase related
K7887_07295	COG3844	kynureninase activity
K7887_07320	COG0697	spore germination
K7887_07335	COG0668	transmembrane transport
K7887_07345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7887_07360	COG1793	dna ligase
K7887_07360	COG3285	dna ligase
K7887_07365	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K7887_07370	COG3320	Male sterility
K7887_07370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K7887_07375	COG1191	sigma factor activity
K7887_07390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K7887_07395	COG1609	Transcriptional regulator
K7887_07415	COG0395	ABC-type sugar transport system, permease component
K7887_07440	COG5002	protein histidine kinase activity
K7887_07445	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K7887_07460	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K7887_07465	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
K7887_07470	COG1278	Cold shock
K7887_07475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K7887_07480	COG0436	Aminotransferase
K7887_07485	COG1850	ribulose-bisphosphate carboxylase activity
K7887_07490	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
K7887_07495	COG0235	Class ii aldolase
K7887_07500	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K7887_07505	COG0446	pyridine nucleotide-disulphide oxidoreductase
K7887_07515	COG2861	carbohydrate metabolic process
K7887_07535	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K7887_07545	COG3639	organic phosphonate transmembrane transporter activity
K7887_07550	COG0737	Belongs to the 5'-nucleotidase family
K7887_07555	COG1846	Transcriptional regulator
K7887_07650	COG0542	response to heat
K7887_07660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K7887_07670	COG3949	Membrane
K7887_07710	COG0720	synthase
K7887_07720	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K7887_07730	COG0702	epimerase
K7887_07740	COG4873	Protein conserved in bacteria
K7887_07800	COG1725	Transcriptional regulator
K7887_07805	COG1131	(ABC) transporter
K7887_07815	COG1131	(ABC) transporter
K7887_07820	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K7887_07835	COG0018	arginyl-trna synthetase
K7887_07850	COG2267	carboxylic ester hydrolase activity
K7887_07865	COG3546	catalase activity
K7887_07870	COG1388	LysM domain
K7887_07870	COG0791	NLP P60 protein
K7887_07905	COG2986	histidine ammonia-lyase
K7887_07915	COG1228	amidohydrolase
K7887_07920	COG0010	Belongs to the arginase family
K7887_07925	COG2084	Dehydrogenase
K7887_07930	COG4191	Histidine kinase
K7887_07935	COG0733	neurotransmitter:sodium symporter activity
K7887_07950	COG1595	DNA-templated transcription, initiation
K7887_07965	COG0436	Aminotransferase
K7887_07980	COG2252	PERMEase
K7887_07990	COG2205	protein histidine kinase activity
K7887_08005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7887_08010	COG0071	Belongs to the small heat shock protein (HSP20) family
K7887_08040	COG1473	amidohydrolase
K7887_08055	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K7887_08060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K7887_08065	COG3594	Acyltransferase
K7887_08085	COG3344	reverse transcriptase
K7887_08090	COG0488	(ABC) transporter
K7887_08100	COG1388	LysM domain
K7887_08100	COG3103	Sh3 type 3 domain protein
K7887_08100	COG0791	NLP P60 protein
K7887_08110	COG3180	Ammonia monooxygenase
K7887_08115	COG2814	Major facilitator Superfamily
K7887_08130	COG1619	proteins homologs of microcin C7 resistance protein MccF
K7887_08140	COG5522	Integral membrane protein (intg_mem_TP0381)
K7887_08165	COG1366	Belongs to the anti-sigma-factor antagonist family
K7887_08200	COG4842	Belongs to the WXG100 family
K7887_08205	COG5417	Belongs to the EsaB family
K7887_08210	COG4499	WXG100 protein secretion system (Wss), protein YukC
K7887_08215	COG1674	ftsk spoiiie
K7887_08215	COG0433	COG0433 Predicted ATPase
K7887_08220	COG1511	domain protein
K7887_08230	COG3829	transcription factor binding
K7887_08230	COG3290	protein histidine kinase activity
K7887_08240	COG0318	PFAM AMP-dependent synthetase and ligase
K7887_08250	COG0183	Belongs to the thiolase family
K7887_08260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K7887_08265	COG0318	PFAM AMP-dependent synthetase and ligase
K7887_08270	COG0702	epimerase
K7887_08285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K7887_08290	COG1090	epimerase
K7887_08295	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K7887_08305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K7887_08315	COG4667	esterase of the alpha-beta hydrolase superfamily
K7887_08320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K7887_08330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K7887_08340	COG0129	dihydroxy-acid dehydratase activity
K7887_08345	COG0028	Belongs to the TPP enzyme family
K7887_08350	COG0440	acetolactate synthase activity
K7887_08355	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K7887_08360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K7887_08370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K7887_08375	COG0066	3-isopropylmalate dehydratase activity
K7887_08390	COG4589	Belongs to the CDS family
K7887_08400	COG0110	maltose O-acetyltransferase activity
K7887_08410	COG1216	Glycosyl transferase, family 2
K7887_08415	COG0523	cobalamin synthesis protein
K7887_08420	COG0860	N-Acetylmuramoyl-L-alanine amidase
K7887_08430	COG0702	epimerase
K7887_08440	COG3610	response to peptide
K7887_08445	COG2966	Psort location CytoplasmicMembrane, score
K7887_08450	COG2340	Cysteine-rich secretory protein family
K7887_08455	COG2188	Transcriptional regulator
K7887_08460	COG0363	glucosamine-6-phosphate deaminase activity
K7887_08465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K7887_08470	COG1247	-acetyltransferase
K7887_08480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K7887_08495	COG1686	Belongs to the peptidase S11 family
K7887_08510	COG1960	acyl-CoA dehydrogenase activity
K7887_08520	COG4145	pantothenate transmembrane transporter activity
K7887_08530	COG2333	competence protein COMEC
K7887_08530	COG0658	competence protein
K7887_08545	COG2190	(PTS) system
K7887_08550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K7887_08550	COG1263	PTS System
K7887_08555	COG0366	Alpha amylase catalytic
K7887_08560	COG0366	Alpha amylase catalytic
K7887_08565	COG2188	Transcriptional regulator
K7887_08575	COG0835	chemotaxis
K7887_08575	COG0784	Response regulator, receiver
K7887_08585	COG3437	response regulator, receiver
K7887_08585	COG2770	Histidine kinase
K7887_08590	COG1376	ErfK ybiS ycfS ynhG family protein
K7887_08595	COG1408	metallophosphoesterase
K7887_08600	COG1028	Short-chain dehydrogenase reductase Sdr
K7887_08610	COG2200	EAL domain
K7887_08630	COG4703	Protein of unknown function (DUF1797)
K7887_08635	COG5506	Protein of unknown function (DUF1694)
K7887_08645	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
K7887_08655	COG0517	IMP dehydrogenase activity
K7887_08660	COG0477	Major facilitator Superfamily
K7887_08670	COG0583	DNA-binding transcription factor activity
K7887_08685	COG1473	amidohydrolase
K7887_08695	COG0668	transmembrane transport
K7887_08700	COG0450	alkyl hydroperoxide reductase
K7887_08705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7887_08710	COG1132	(ABC) transporter
K7887_08715	COG1132	(ABC) transporter
K7887_08725	COG0569	domain protein
K7887_08730	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K7887_08740	COG0697	spore germination
K7887_08745	COG0561	phosphatase activity
K7887_08765	COG0022	dehydrogenase e1 component
K7887_08770	COG0508	dehydrogenase complex catalyzes the overall conversion of
K7887_08775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K7887_08805	COG1982	Orn Lys Arg decarboxylase major
K7887_08815	COG4476	Belongs to the UPF0223 family
K7887_08820	COG4493	Belongs to the UPF0637 family
K7887_08830	COG0483	inositol monophosphate 1-phosphatase activity
K7887_08840	COG1217	gtp-binding protein TYPA
K7887_08860	COG4896	Protein conserved in bacteria
K7887_08875	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K7887_08880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K7887_08885	COG2066	Belongs to the glutaminase family
K7887_08890	COG4838	Belongs to the UPF0358 family
K7887_08895	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K7887_08900	COG0415	Belongs to the DNA photolyase family
K7887_08905	COG1612	heme a metabolic process
K7887_08935	COG3336	cytochrome c oxidase
K7887_08945	COG0628	permease
K7887_08960	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
K7887_08965	COG2340	Cysteine-rich secretory protein family
K7887_08995	COG3679	Belongs to the UPF0342 family
K7887_09005	COG4471	UPF0298 protein
K7887_09020	COG0742	ribosomal rna small subunit methyltransferase
K7887_09025	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K7887_09030	COG3314	Sporulation integral membrane protein YlbJ
K7887_09035	COG1752	Esterase of the alpha-beta hydrolase superfamily
K7887_09040	COG3480	Lon protease (S16) C-terminal proteolytic domain
K7887_09050	COG1399	metal-binding, possibly nucleic acid-binding protein
K7887_09055	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K7887_09060	COG1024	Enoyl-CoA hydratase
K7887_09070	COG3011	Protein conserved in bacteria
K7887_09080	COG0454	-acetyltransferase
K7887_09085	COG0439	Biotin carboxylase
K7887_09090	COG0511	ligase activity, forming carbon-carbon bonds
K7887_09095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K7887_09100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K7887_09110	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
K7887_09115	COG2001	Belongs to the MraZ family
K7887_09120	COG0275	rRNA processing
K7887_09130	COG0768	penicillin binding
K7887_09135	COG0768	penicillin binding
K7887_09145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K7887_09150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K7887_09155	COG0772	Belongs to the SEDS family
K7887_09160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K7887_09165	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K7887_09170	COG3879	Bacterial protein of unknown function (DUF881)
K7887_09175	COG3879	Bacterial protein of unknown function (DUF881)
K7887_09180	COG3856	small basic protein
K7887_09185	COG0849	cell division
K7887_09190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K7887_09200	COG1191	sigma factor activity
K7887_09205	COG1191	sigma factor activity
K7887_09210	COG1873	PFAM PRC-barrel domain
K7887_09215	COG1496	oxidoreductase activity
K7887_09220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K7887_09225	COG1799	cell septum assembly
K7887_09230	COG0762	integral membrane protein
K7887_09235	COG2302	S4 RNA-binding domain
K7887_09240	COG3599	regulation of cell shape
K7887_09250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K7887_09255	COG0564	pseudouridine synthase activity
K7887_09260	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K7887_09265	COG2233	PERMEase
K7887_09270	COG0540	Belongs to the ATCase OTCase family
K7887_09275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K7887_09290	COG0543	2 iron, 2 sulfur cluster binding
K7887_09300	COG0284	orotidine-5'-phosphate decarboxylase activity
K7887_09305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K7887_09325	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K7887_09330	COG1561	YicC-like family, N-terminal region
K7887_09335	COG2052	Domain of unknown function (DUF370)
K7887_09345	COG1758	RNA polymerase activity
K7887_09350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K7887_09355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K7887_09365	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K7887_09370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K7887_09370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K7887_09375	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K7887_09380	COG0631	protein serine/threonine phosphatase activity
K7887_09385	COG2815	serine threonine protein kinase
K7887_09385	COG0515	serine threonine protein kinase
K7887_09390	COG1162	GTPase activity
K7887_09395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K7887_09405	COG1564	THIamine pyrophosphokinase
K7887_09415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K7887_09420	COG1302	Protein conserved in bacteria
K7887_09425	COG1461	Dihydroxyacetone kinase
K7887_09430	COG1760	l-serine dehydratase
K7887_09435	COG1760	l-serine dehydratase
K7887_09440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K7887_09445	COG1349	DNA-binding transcription factor activity
K7887_09445	COG2050	protein possibly involved in aromatic compounds catabolism
K7887_09450	COG0416	fatty acid biosynthetic process
K7887_09455	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K7887_09460	COG1028	Short-chain dehydrogenase reductase Sdr
K7887_09465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K7887_09470	COG0571	ribonuclease III activity
K7887_09475	COG1196	nuclear chromosome segregation
K7887_09480	COG0552	protein localization to endoplasmic reticulum
K7887_09485	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K7887_09490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K7887_09500	COG1837	Belongs to the UPF0109 family
K7887_09505	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K7887_09510	COG0336	Belongs to the RNA methyltransferase TrmD family
K7887_09540	COG2257	FlhB HrpN YscU SpaS Family
K7887_09550	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K7887_09555	COG0758	DNA mediated transformation
K7887_09560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K7887_09565	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K7887_09570	COG4974	Belongs to the 'phage' integrase family
K7887_09575	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K7887_09580	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K7887_09585	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
K7887_09590	COG1815	bacterial-type flagellum-dependent cell motility
K7887_09595	COG1558	bacterial-type flagellum-dependent cell motility
K7887_09600	COG1677	Flagellar hook-basal body complex protein FliE
K7887_09605	COG1766	The M ring may be actively involved in energy transduction
K7887_09610	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K7887_09615	COG1317	bacterial-type flagellum organization
K7887_09620	COG1157	protein secretion by the type III secretion system
K7887_09635	COG3144	bacterial-type flagellum assembly
K7887_09640	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K7887_09660	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K7887_09665	COG1776	CheC inhibitor of MCP methylation
K7887_09665	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K7887_09670	COG2201	protein-glutamate methylesterase activity
K7887_09675	COG3190	flagellar
K7887_09680	COG1338	Plays a role in the flagellum-specific transport system
K7887_09685	COG1987	bacterial-type flagellum assembly
K7887_09690	COG1684	flagellar biosynthetic protein fliR
K7887_09695	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K7887_09700	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K7887_09705	COG1419	protein localization to endoplasmic reticulum
K7887_09710	COG0455	bacterial-type flagellum organization
K7887_09715	COG2201	protein-glutamate methylesterase activity
K7887_09720	COG2198	Histidine kinase
K7887_09720	COG0643	Histidine kinase
K7887_09725	COG0835	chemotaxis
K7887_09730	COG1776	CheC inhibitor of MCP methylation
K7887_09735	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K7887_09740	COG1191	sigma factor activity
K7887_09750	COG0052	Belongs to the universal ribosomal protein uS2 family
K7887_09775	COG4589	Belongs to the CDS family
K7887_09780	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K7887_09785	COG0750	zinc metalloprotease
K7887_09795	COG2176	DNA-directed DNA polymerase activity
K7887_09805	COG0195	Participates in both transcription termination and antitermination
K7887_09810	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K7887_09815	COG1358	cellular component organization or biogenesis
K7887_09825	COG1550	Protein conserved in bacteria
K7887_09830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K7887_09835	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K7887_09840	COG0196	riboflavin kinase activity
K7887_09845	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K7887_09850	COG1185	polyribonucleotide nucleotidyltransferase activity
K7887_09855	COG0726	polysaccharide deacetylase
K7887_09860	COG0612	Peptidase, M16
K7887_09865	COG1873	PFAM PRC-barrel domain
K7887_09870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K7887_09875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K7887_09880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K7887_09885	COG0527	aspartate kinase activity
K7887_09890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K7887_09895	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K7887_09900	COG0740	serine-type endopeptidase activity
K7887_09910	COG4980	gas vesicle protein
K7887_09910	COG1674	ftsk spoiiie
K7887_09915	COG2188	Transcriptional regulator
K7887_09920	COG0612	Peptidase, M16
K7887_09925	COG0612	Peptidase, M16
K7887_09930	COG0300	oxidoreductase activity
K7887_09945	COG1426	Protein conserved in bacteria
K7887_09950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K7887_09955	COG1546	Belongs to the CinA family
K7887_09955	COG1058	Belongs to the CinA family
K7887_09965	COG1418	mRNA catabolic process
K7887_09970	COG1692	metallophosphoesterase
K7887_09975	COG2359	stage V sporulation protein S
K7887_09985	COG0674	pyruvate-flavodoxin oxidoreductase activity
K7887_09985	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K7887_09990	COG1013	pyruvate-flavodoxin oxidoreductase activity
K7887_09995	COG1063	alcohol dehydrogenase
K7887_10000	COG0156	8-amino-7-oxononanoate synthase activity
K7887_10005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K7887_10010	COG4550	Control of competence regulator ComK, YlbF/YmcA
K7887_10020	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K7887_10040	COG0464	growth
K7887_10045	COG1233	COG1233 Phytoene dehydrogenase and related
K7887_10055	COG2860	membrane
K7887_10060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K7887_10065	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
K7887_10070	COG0789	Transcriptional regulator
K7887_10075	COG0174	glutamine synthetase
K7887_10095	COG2323	membrane
K7887_10100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K7887_10105	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K7887_10110	COG4224	UPF0291 protein
K7887_10125	COG3763	UPF0154 protein
K7887_10130	COG1132	(ABC) transporter
K7887_10135	COG1132	(ABC) transporter
K7887_10150	COG0785	Cytochrome C biogenesis protein
K7887_10155	COG2201	protein-glutamate methylesterase activity
K7887_10160	COG4846	Membrane protein involved in cytochrome C biogenesis
K7887_10170	COG1484	DNA-dependent DNA replication
K7887_10175	COG0714	Associated with various cellular activities
K7887_10190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K7887_10195	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K7887_10200	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K7887_10255	COG1131	(ABC) transporter
K7887_10335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K7887_10345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7887_10375	COG0824	Thioesterase
K7887_10385	COG4841	protein insertion into membrane
K7887_10390	COG2843	Capsule synthesis protein
K7887_10430	COG4326	sporulation control protein
K7887_10435	COG0588	phosphoglycerate mutase activity
K7887_10450	COG0346	lactoylglutathione lyase activity
K7887_10460	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K7887_10465	COG1832	CoA-binding protein
K7887_10470	COG0187	DNA topoisomerase II activity
K7887_10475	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K7887_10480	COG1335	isochorismatase
K7887_10485	COG0590	tRNA wobble adenosine to inosine editing
K7887_10495	COG2814	Major facilitator Superfamily
K7887_10500	COG1733	regulation of RNA biosynthetic process
K7887_10510	COG3559	Exporter of polyketide antibiotics
K7887_10515	COG1131	(ABC) transporter
K7887_10520	COG1309	transcriptional regulator
K7887_10545	COG1054	Belongs to the UPF0176 family
K7887_10550	COG3459	Glycosyltransferase 36 associated
K7887_10555	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K7887_10560	COG1823	symporter activity
K7887_10565	COG3906	Belongs to the UPF0473 family
K7887_10585	COG2197	response regulator
K7887_10590	COG4585	Histidine kinase
K7887_10595	COG1994	Peptidase M50
K7887_10605	COG1271	oxidase subunit
K7887_10610	COG1294	oxidase, subunit
K7887_10630	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K7887_10635	COG4565	transcriptional regulatory protein
K7887_10640	COG3290	protein histidine kinase activity
K7887_10645	COG2391	methyltransferase activity
K7887_10665	COG0662	Cupin 2, conserved barrel domain protein
K7887_10670	COG0346	lactoylglutathione lyase activity
K7887_10680	COG1714	RDD family
K7887_10695	COG0714	Associated with various cellular activities
K7887_10715	COG0322	excinuclease ABC activity
K7887_10720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K7887_10725	COG1785	Belongs to the alkaline phosphatase family
K7887_10730	COG1082	Xylose isomerase domain protein TIM barrel
K7887_10740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K7887_10760	COG2207	Transcriptional regulator
K7887_10760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K7887_10770	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K7887_10780	COG0003	Pfam Anion-transporting ATPase
K7887_10790	COG1966	Carbon starvation protein
K7887_10805	COG0514	ATP-dependent DNA helicase (RecQ)
K7887_10815	COG2353	YceI-like domain
K7887_10830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7887_10850	COG2309	aminopeptidase activity
K7887_10870	COG0708	Exodeoxyribonuclease III
K7887_10890	COG0644	oxidoreductase
K7887_10895	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K7887_10905	COG0583	DNA-binding transcription factor activity
K7887_10910	COG0372	Belongs to the citrate synthase family
K7887_10915	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K7887_10935	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
K7887_10940	COG1295	ribonuclease BN
K7887_10945	COG1834	amidinotransferase
K7887_10950	COG2340	Cysteine-rich secretory protein family
K7887_10955	COG0673	inositol 2-dehydrogenase activity
K7887_10960	COG0693	protein deglycase activity
K7887_10965	COG0165	Argininosuccinate lyase
K7887_10970	COG0137	argininosuccinate synthase activity
K7887_10975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K7887_10980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K7887_10985	COG0505	Belongs to the CarA family
K7887_10990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K7887_10995	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K7887_11000	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K7887_11015	COG0673	inositol 2-dehydrogenase activity
K7887_11040	COG0318	PFAM AMP-dependent synthetase and ligase
K7887_11050	COG2223	nitrite transmembrane transporter activity
K7887_11060	COG0346	lactoylglutathione lyase activity
K7887_11065	COG2404	hydrolase activity, acting on ester bonds
K7887_11070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K7887_11085	COG0514	ATP-dependent DNA helicase (RecQ)
K7887_11090	COG1012	belongs to the aldehyde dehydrogenase family
K7887_11110	COG0488	(ABC) transporter
K7887_11115	COG0628	permease
K7887_11120	COG1272	protein, Hemolysin III
K7887_11130	COG2133	pyrroloquinoline quinone binding
K7887_11140	COG2226	methyltransferase
K7887_11150	COG3773	Cell wall hydrolase
K7887_11175	COG0406	alpha-ribazole phosphatase activity
K7887_11180	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K7887_11190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K7887_11195	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K7887_11200	COG1120	ATPase activity
K7887_11205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7887_11210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K7887_11215	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K7887_11220	COG1492	cobalamin metabolic process
K7887_11230	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K7887_11240	COG1595	DNA-templated transcription, initiation
K7887_11285	COG5002	protein histidine kinase activity
K7887_11290	COG0745	RESPONSE REGULATOR receiver
K7887_11330	COG0772	Belongs to the SEDS family
K7887_11340	COG1595	DNA-templated transcription, initiation
K7887_11420	COG3853	Toxic anion resistance protein (TelA)
K7887_11430	COG1012	belongs to the aldehyde dehydrogenase family
K7887_11445	COG0671	phosphoesterase, PA-phosphatase related
K7887_11450	COG4548	von Willebrand factor, type A
K7887_11455	COG0714	Associated with various cellular activities
K7887_11460	COG0861	Integral membrane protein TerC family
K7887_11465	COG0534	Mate efflux family protein
K7887_11475	COG2340	Cysteine-rich secretory protein family
K7887_11485	COG0179	Fumarylacetoacetate (FAA) hydrolase
K7887_11490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K7887_11495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K7887_11500	COG3185	4-Hydroxyphenylpyruvate dioxygenase
K7887_11535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K7887_11540	COG4120	Belongs to the binding-protein-dependent transport system permease family
K7887_11560	COG3327	negative regulation of DNA-templated transcription, initiation
K7887_11570	COG1250	3-hydroxyacyl-CoA dehydrogenase
K7887_11575	COG1012	belongs to the aldehyde dehydrogenase family
K7887_11580	COG1024	Enoyl-CoA hydratase
K7887_11610	COG3396	Phenylacetate-CoA oxygenase
K7887_11630	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K7887_11635	COG0400	carboxylic ester hydrolase activity
K7887_11655	COG1876	peptidase activity
K7887_11660	COG0432	Pfam Uncharacterised protein family UPF0047
K7887_11700	COG4479	Belongs to the UPF0346 family
K7887_11710	COG1509	lysine 2,3-aminomutase activity
K7887_11715	COG3829	transcription factor binding
K7887_11720	COG0456	acetyltransferase
K7887_11730	COG0697	spore germination
K7887_11735	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K7887_11745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K7887_11750	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K7887_11755	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K7887_11760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K7887_11780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K7887_11780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K7887_11805	COG0789	Transcriptional regulator
K7887_11810	COG3275	phosphorelay sensor kinase activity
K7887_11820	COG1966	Carbon starvation protein
K7887_11850	COG2755	lipolytic protein G-D-S-L family
K7887_11860	COG1999	signal sequence binding
K7887_11865	COG2814	Major facilitator Superfamily
K7887_11885	COG0714	Associated with various cellular activities
K7887_11900	COG1131	(ABC) transporter
K7887_11950	COG2135	peptidase activity
K7887_11960	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K7887_11975	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K7887_11985	COG2136	Putative SAM-dependent methyltransferase
K7887_11985	COG2521	methyltransferase
K7887_11995	COG1413	lyase activity
K7887_12000	COG0488	(ABC) transporter
K7887_12005	COG1418	mRNA catabolic process
K7887_12015	COG1307	EDD domain protein, DegV family
K7887_12025	COG0386	Belongs to the glutathione peroxidase family
K7887_12035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K7887_12065	COG2808	Putative FMN-binding domain
K7887_12075	COG4555	ABC transporter
K7887_12090	COG0390	transport system, permease component
K7887_12095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K7887_12100	COG0551	DNA topoisomerase type I activity
K7887_12100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K7887_12110	COG1278	Cold shock
K7887_12125	COG0328	RNA-DNA hybrid ribonuclease activity
K7887_12130	COG0328	RNA-DNA hybrid ribonuclease activity
K7887_12140	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
K7887_12150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K7887_12165	COG3541	Predicted nucleotidyltransferase
K7887_12170	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K7887_12175	COG1755	Isoprenylcysteine carboxyl methyltransferase
K7887_12180	COG3424	synthase
K7887_12195	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K7887_12200	COG1199	ATP-dependent helicase activity
K7887_12215	COG0116	Belongs to the methyltransferase superfamily
K7887_12240	COG3359	exonuclease
K7887_12245	COG1111	helicase
K7887_12245	COG1205	dead DEAH box helicase
K7887_12300	COG3344	reverse transcriptase
K7887_12310	COG3331	DNA recombination
K7887_12315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K7887_12315	COG4499	WXG100 protein secretion system (Wss), protein YukC
K7887_12325	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K7887_12330	COG3935	DnaD domain protein
K7887_12335	COG0017	Asparaginyl-tRNA synthetase
K7887_12355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K7887_12355	COG1199	ATP-dependent helicase activity
K7887_12360	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K7887_12380	COG0617	tRNA 3'-terminal CCA addition
K7887_12385	COG0438	transferase activity, transferring glycosyl groups
K7887_12390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K7887_12395	COG1803	Methylglyoxal synthase
K7887_12405	COG1694	Mazg nucleotide pyrophosphohydrolase
K7887_12410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K7887_12415	COG2738	Putative neutral zinc metallopeptidase
K7887_12425	COG4347	Protein of unknown function (DUF1405)
K7887_12435	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K7887_12450	COG5582	Belongs to the UPF0302 family
K7887_12455	COG0457	Tetratricopeptide repeat
K7887_12465	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K7887_12470	COG0287	Prephenate dehydrogenase
K7887_12475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K7887_12480	COG0159	tryptophan synthase activity
K7887_12485	COG0133	tryptophan synthase activity
K7887_12490	COG0135	phosphoribosylanthranilate isomerase activity
K7887_12495	COG0134	indole-3-glycerol-phosphate synthase activity
K7887_12500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K7887_12510	COG4401	Chorismate mutase type I
K7887_12515	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K7887_12520	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K7887_12525	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K7887_12530	COG0105	UTP biosynthetic process
K7887_12535	COG0142	geranyltranstransferase activity
K7887_12540	COG2226	methyltransferase
K7887_12545	COG0142	geranyltranstransferase activity
K7887_12555	COG0302	gtp cyclohydrolase
K7887_12560	COG0776	regulation of translation
K7887_12565	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K7887_12610	COG1304	FMN binding
K7887_12615	COG0539	negative regulation of cytoplasmic translation
K7887_12625	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K7887_12640	COG2959	enzyme of heme biosynthesis
K7887_12645	COG3773	Cell wall hydrolase
K7887_12645	COG3409	Peptidoglycan-binding domain 1 protein
K7887_12650	COG2339	peptidase activity
K7887_12660	COG0492	ferredoxin-NADP+ reductase activity
K7887_12665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K7887_12670	COG4862	establishment of competence for transformation
K7887_12675	COG0789	Transcriptional regulator
K7887_12680	COG1408	metallophosphoesterase
K7887_12695	COG1266	CAAX protease self-immunity
K7887_12700	COG0514	ATP-dependent DNA helicase (RecQ)
K7887_12705	COG4955	Helix-turn-helix domain
K7887_12710	COG1141	Ferredoxin
K7887_12715	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K7887_12720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K7887_12725	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K7887_12735	COG1028	Short-chain dehydrogenase reductase Sdr
K7887_12740	COG2610	gluconate transmembrane transporter activity
K7887_12750	COG1595	DNA-templated transcription, initiation
K7887_12765	COG5002	protein histidine kinase activity
K7887_12770	COG0745	RESPONSE REGULATOR receiver
K7887_12775	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K7887_12780	COG1333	cytochrome c biogenesis protein
K7887_12785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7887_12790	COG1187	pseudouridine synthase activity
K7887_12795	COG0700	Nucleoside recognition
K7887_12800	COG2715	membrane protein required for spore maturation
K7887_12805	COG1686	Belongs to the peptidase S11 family
K7887_12810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K7887_12825	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K7887_12830	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K7887_12835	COG1547	Domain of unknown function (DUF309)
K7887_12845	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K7887_12850	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K7887_12850	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K7887_12855	COG0307	riboflavin synthase, alpha
K7887_12860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K7887_12860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K7887_12865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K7887_12875	COG0697	spore germination
K7887_12890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K7887_12925	COG1686	Belongs to the peptidase S11 family
K7887_12945	COG4974	Belongs to the 'phage' integrase family
K7887_12955	COG0735	belongs to the Fur family
K7887_12960	COG1300	Membrane
K7887_12965	COG1379	DNA repair
K7887_12970	COG0494	nUDIX hydrolase
K7887_12980	COG0667	Aldo Keto reductase
K7887_12995	COG0753	catalase activity
K7887_13020	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K7887_13035	COG0477	Major facilitator Superfamily
K7887_13045	COG2217	Heavy metal translocating P-type atpase
K7887_13080	COG3340	Belongs to the peptidase S51 family
K7887_13090	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K7887_13095	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K7887_13100	COG0183	Belongs to the thiolase family
K7887_13105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K7887_13110	COG1742	UPF0060 membrane protein
K7887_13150	COG2226	methyltransferase
K7887_13165	COG1073	alpha beta
K7887_13180	COG0778	Nitroreductase
K7887_13185	COG3403	YqcI/YcgG family
K7887_13190	COG1280	lysine exporter protein (LysE YggA)
K7887_13195	COG0454	-acetyltransferase
K7887_13200	COG2824	Alkylphosphonate utilization operon protein PhnA
K7887_13210	COG1476	TRANSCRIPTIONal
K7887_13245	COG2755	lipolytic protein G-D-S-L family
K7887_13265	COG1136	(ABC) transporter
K7887_13270	COG2205	protein histidine kinase activity
K7887_13275	COG0745	RESPONSE REGULATOR receiver
K7887_13290	COG1193	negative regulation of DNA recombination
K7887_13295	COG2323	membrane
K7887_13310	COG0456	acetyltransferase
K7887_13320	COG0681	Belongs to the peptidase S26 family
K7887_13345	COG1131	(ABC) transporter
K7887_13390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K7887_13415	COG0300	oxidoreductase activity
K7887_13420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K7887_13425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K7887_13440	COG4187	Peptidase family M20/M25/M40
K7887_13445	COG1902	pentaerythritol trinitrate reductase activity
K7887_13455	COG0500	methyltransferase
K7887_13455	COG3615	Tellurite resistance protein tehB
K7887_13460	COG1234	tRNA 3'-trailer cleavage
K7887_13485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K7887_13490	COG1846	Transcriptional regulator
K7887_13495	COG1764	response to oxidative stress
K7887_13500	COG0835	chemotaxis
K7887_13505	COG2195	Cleaves the N-terminal amino acid of tripeptides
K7887_13515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K7887_13520	COG0346	lactoylglutathione lyase activity
K7887_13540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K7887_13550	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K7887_13555	COG1942	4-Oxalocrotonate Tautomerase
K7887_13565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K7887_13585	COG0251	oxidation-reduction process
K7887_13605	COG2368	4-hydroxyphenylacetate
K7887_13610	COG1376	ErfK ybiS ycfS ynhG family protein
K7887_13615	COG4129	membrane
K7887_13620	COG1164	Oligoendopeptidase f
K7887_13630	COG1126	abc transporter atp-binding protein
K7887_13635	COG0765	amino acid transport
K7887_13640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7887_13650	COG1595	DNA-templated transcription, initiation
K7887_13655	COG5002	protein histidine kinase activity
K7887_13675	COG1703	isobutyryl-CoA mutase activity
K7887_13680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K7887_13680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K7887_13685	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K7887_13700	COG0508	dehydrogenase complex catalyzes the overall conversion of
K7887_13705	COG0022	dehydrogenase e1 component
K7887_13710	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K7887_13715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K7887_13730	COG0280	phosphate acetyltransferase
K7887_13735	COG3290	protein histidine kinase activity
K7887_13735	COG3829	transcription factor binding
K7887_13745	COG0584	glycerophosphoryl diester phosphodiesterase
K7887_13750	COG3093	addiction module antidote protein HigA
K7887_13755	COG0745	RESPONSE REGULATOR receiver
K7887_13760	COG0750	zinc metalloprotease
K7887_13770	COG0497	DNA recombination
K7887_13775	COG1438	arginine binding
K7887_13780	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K7887_13785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K7887_13795	COG0142	geranyltranstransferase activity
K7887_13800	COG1722	exodeoxyribonuclease VII activity
K7887_13805	COG1570	exodeoxyribonuclease VII activity
K7887_13810	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K7887_13820	COG1302	Protein conserved in bacteria
K7887_13825	COG0439	Biotin carboxylase
K7887_13830	COG0511	ligase activity, forming carbon-carbon bonds
K7887_13870	COG3854	ATPases associated with a variety of cellular activities
K7887_13880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K7887_13890	COG0778	Nitroreductase
K7887_13910	COG2249	NAD(P)H dehydrogenase (quinone) activity
K7887_13935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K7887_13955	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K7887_13960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K7887_13980	COG1063	alcohol dehydrogenase
K7887_14085	COG1247	-acetyltransferase
K7887_14125	COG1404	Belongs to the peptidase S8 family
K7887_14145	COG2267	carboxylic ester hydrolase activity
K7887_14150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K7887_14155	COG1172	Belongs to the binding-protein-dependent transport system permease family
K7887_14160	COG1129	ABC transporter
K7887_14170	COG0366	Alpha amylase catalytic
K7887_14180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K7887_14185	COG0006	proline dipeptidase activity
K7887_14190	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K7887_14200	COG3872	metal-dependent enzyme
K7887_14210	COG1752	Esterase of the alpha-beta hydrolase superfamily
K7887_14215	COG1321	iron dependent repressor
K7887_14235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K7887_14240	COG0095	Lipoate-protein ligase
K7887_14245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K7887_14260	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K7887_14265	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K7887_14270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K7887_14295	COG2207	Transcriptional regulator
K7887_14295	COG3708	Transcriptional regulator
K7887_14330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K7887_14365	COG4970	Tfp pilus assembly protein FimT
K7887_14370	COG4537	Required for transformation and DNA binding
K7887_14380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K7887_14390	COG4608	Belongs to the ABC transporter superfamily
K7887_14395	COG0791	NLP P60 protein
K7887_14400	COG4948	Mandelate Racemase Muconate Lactonizing
K7887_14405	COG1619	proteins homologs of microcin C7 resistance protein MccF
K7887_14410	COG4166	transmembrane transport
K7887_14415	COG0444	Belongs to the ABC transporter superfamily
K7887_14420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7887_14425	COG0601	transmembrane transport
K7887_14430	COG2362	D-Aminopeptidase
K7887_14435	COG0693	protein deglycase activity
K7887_14445	COG4191	Histidine kinase
K7887_14455	COG0823	Involved in the tonB-independent uptake of proteins
K7887_14485	COG1393	Belongs to the ArsC family
K7887_14500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K7887_14515	COG0011	TIGRFAM Protein of
K7887_14530	COG1368	sulfuric ester hydrolase activity
K7887_14535	COG1940	carbohydrate kinase activity
K7887_14545	COG0697	spore germination
K7887_14550	COG0457	Tetratricopeptide repeat
K7887_14550	COG0705	Rhomboid family
K7887_14555	COG0840	transmembrane signaling receptor activity
K7887_14565	COG0039	L-malate dehydrogenase activity
K7887_14575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K7887_14585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K7887_14625	COG0604	alcohol dehydrogenase
K7887_14650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K7887_14655	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K7887_14660	COG0640	Transcriptional regulator
K7887_14670	COG0659	secondary active sulfate transmembrane transporter activity
K7887_14675	COG0704	Plays a role in the regulation of phosphate uptake
K7887_14680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K7887_14685	COG0581	inorganic phosphate transmembrane transporter activity
K7887_14690	COG0573	inorganic phosphate transmembrane transporter activity
K7887_14695	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K7887_14700	COG0768	penicillin binding
K7887_14705	COG0477	Major facilitator Superfamily
K7887_14715	COG0205	6-phosphofructokinase activity
K7887_14720	COG2839	Protein conserved in bacteria
K7887_14725	COG1283	sodium-dependent phosphate transmembrane transporter activity
K7887_14740	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K7887_14745	COG4709	membrane
K7887_14750	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
K7887_14760	COG0735	belongs to the Fur family
K7887_14765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K7887_14770	COG1121	(ABC) transporter
K7887_14775	COG3852	Histidine kinase
K7887_14790	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K7887_14805	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K7887_14815	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K7887_14820	COG2384	SAM-dependent methyltransferase
K7887_14825	COG2010	Cytochrome c
K7887_14830	COG1960	acyl-CoA dehydrogenase activity
K7887_14840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K7887_14845	COG0358	DNA primase activity
K7887_14850	COG1671	Belongs to the UPF0178 family
K7887_14860	COG0517	IMP dehydrogenase activity
K7887_14865	COG0751	glycine-tRNA ligase activity
K7887_14870	COG0752	glycyl-tRNA synthetase alpha subunit
K7887_14875	COG1381	Involved in DNA repair and RecF pathway recombination
K7887_14885	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K7887_14890	COG0295	cytidine deaminase activity
K7887_14895	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K7887_14900	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K7887_14905	COG1480	7TM receptor with intracellular HD hydrolase
K7887_14910	COG1702	phosphate starvation-inducible protein PhoH
K7887_14930	COG4864	UPF0365 protein
K7887_14935	COG1030	water channel activity
K7887_14940	COG1610	YqeY-like protein
K7887_14955	COG1283	sodium-dependent phosphate transmembrane transporter activity
K7887_14960	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K7887_14965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K7887_14970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K7887_14975	COG2264	protein methyltransferase activity
K7887_14980	COG0484	heat shock protein binding
K7887_14985	COG0443	Heat shock 70 kDa protein
K7887_14990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K7887_14995	COG1420	regulation of RNA biosynthetic process
K7887_15000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K7887_15015	COG0860	N-Acetylmuramoyl-L-alanine amidase
K7887_15020	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
K7887_15030	COG1466	dna polymerase III delta subunit
K7887_15040	COG2333	competence protein COMEC
K7887_15040	COG0658	competence protein
K7887_15045	COG2131	deaminase
K7887_15050	COG1555	photosystem II stabilization
K7887_15050	COG1596	polysaccharide export
K7887_15055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K7887_15060	COG3344	reverse transcriptase
K7887_15065	COG2226	methyltransferase
K7887_15070	COG0799	negative regulation of ribosome biogenesis
K7887_15075	COG1713	HD superfamily hydrolase involved in NAD metabolism
K7887_15080	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K7887_15085	COG1534	Rna-binding protein
K7887_15095	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K7887_15100	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
K7887_15110	COG0688	phosphatidylethanolamine metabolic process
K7887_15140	COG1174	glycine betaine transport
K7887_15145	COG0517	IMP dehydrogenase activity
K7887_15145	COG1125	glycine betaine transport
K7887_15150	COG1525	nuclease
K7887_15165	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K7887_15170	COG0626	cystathionine gamma-synthase activity
K7887_15175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K7887_15180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K7887_15185	COG2226	methyltransferase
K7887_15200	COG0768	penicillin binding
K7887_15205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K7887_15210	COG0572	uridine kinase
K7887_15215	COG0826	peptidase U32
K7887_15220	COG0826	peptidase U32
K7887_15225	COG4122	O-methyltransferase activity
K7887_15230	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K7887_15235	COG1959	2 iron, 2 sulfur cluster binding
K7887_15240	COG3906	Belongs to the UPF0473 family
K7887_15245	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K7887_15250	COG4472	Bacterial protein of unknown function (DUF965)
K7887_15255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K7887_15260	COG0628	permease
K7887_15265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K7887_15270	COG1012	belongs to the aldehyde dehydrogenase family
K7887_15275	COG3835	regulator
K7887_15305	COG0493	'glutamate synthase
K7887_15335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K7887_15345	COG0482	sulfurtransferase activity
K7887_15350	COG1104	cysteine desulfurase activity
K7887_15355	COG1959	2 iron, 2 sulfur cluster binding
K7887_15360	COG2364	Membrane
K7887_15365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K7887_15380	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K7887_15395	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K7887_15400	COG0124	histidyl-tRNA synthetase
K7887_15410	COG3103	Sh3 type 3 domain protein
K7887_15410	COG0860	N-Acetylmuramoyl-L-alanine amidase
K7887_15410	COG4991	sh3 domain protein
K7887_15415	COG1490	D-aminoacyl-tRNA deacylase activity
K7887_15420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K7887_15430	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K7887_15430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K7887_15435	COG5416	Lipopolysaccharide assembly protein A domain
K7887_15440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K7887_15445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K7887_15445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K7887_15455	COG2244	polysaccharide biosynthetic process
K7887_15460	COG2323	membrane
K7887_15470	COG1862	Preprotein translocase
K7887_15475	COG0343	queuine tRNA-ribosyltransferase activity
K7887_15480	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K7887_15490	COG2255	four-way junction helicase activity
K7887_15510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K7887_15520	COG1388	LysM domain
K7887_15530	COG0157	Belongs to the NadC ModD family
K7887_15535	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K7887_15540	COG1104	cysteine desulfurase activity
K7887_15545	COG1827	regulation of RNA biosynthetic process
K7887_15550	COG0077	Prephenate dehydratase
K7887_15555	COG4492	Belongs to the UPF0735 family
K7887_15560	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K7887_15565	COG3290	protein histidine kinase activity
K7887_15575	COG2868	ribosomal protein
K7887_15585	COG1530	ribonuclease E activity
K7887_15590	COG1994	Peptidase M50
K7887_15595	COG0739	heme binding
K7887_15620	COG2894	cell division
K7887_15625	COG0850	regulation of cytokinetic process
K7887_15630	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K7887_15635	COG1792	Involved in formation and maintenance of cell shape
K7887_15640	COG1077	Cell shape determining protein MreB Mrl
K7887_15645	COG2003	Belongs to the UPF0758 family
K7887_15675	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K7887_15685	COG1459	type II secretion system
K7887_15695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K7887_15705	COG1595	DNA-templated transcription, initiation
K7887_15720	COG0285	dihydrofolate synthase activity
K7887_15735	COG0189	ligase activity
K7887_15755	COG0525	valine-tRNA ligase activity
K7887_15765	COG0840	transmembrane signaling receptor activity
K7887_15770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K7887_15775	COG1388	LysM domain
K7887_15775	COG1388	LysM domain
K7887_15780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K7887_15785	COG0113	porphobilinogen synthase activity
K7887_15795	COG0181	hydroxymethylbilane synthase activity
K7887_15800	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K7887_15815	COG1126	abc transporter atp-binding protein
K7887_15820	COG0765	amino acid transport
K7887_15825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7887_15830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K7887_15835	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K7887_15840	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K7887_15845	COG0470	DNA polymerase III
K7887_15845	COG1067	ATP-dependent peptidase activity
K7887_15850	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K7887_15855	COG0544	peptidyl-prolyl cis-trans isomerase activity
K7887_15860	COG1477	protein flavinylation
K7887_15860	COG0457	Tetratricopeptide repeat
K7887_15870	COG0622	Phosphoesterase
K7887_15875	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K7887_15880	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K7887_15885	COG5401	PFAM Sporulation and spore germination
K7887_15895	COG1846	Transcriptional regulator
K7887_15900	COG2197	response regulator
K7887_15905	COG0824	Thioesterase
K7887_15910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K7887_15915	COG1053	succinate dehydrogenase
K7887_15920	COG2009	succinate dehydrogenase
K7887_15925	COG1719	4-vinyl reductase, 4VR
K7887_15935	COG0322	excinuclease ABC activity
K7887_15940	COG3118	belongs to the thioredoxin family
K7887_15945	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K7887_15950	COG2086	electron transfer activity
K7887_15955	COG1024	Enoyl-CoA hydratase
K7887_15960	COG1309	transcriptional regulator
K7887_15965	COG0318	PFAM AMP-dependent synthetase and ligase
K7887_15970	COG0475	glutathione-regulated potassium exporter activity
K7887_15975	COG0490	domain, Protein
K7887_15980	COG3766	membrane
K7887_15985	COG1193	negative regulation of DNA recombination
K7887_15990	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K7887_15990	COG1796	DNA polymerase
K7887_15995	COG1286	toxin biosynthetic process
K7887_16000	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K7887_16005	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K7887_16010	COG0072	phenylalanine-tRNA ligase activity
K7887_16010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K7887_16015	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K7887_16020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K7887_16030	COG1363	Peptidase, m42
K7887_16055	COG1263	PTS System
K7887_16055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K7887_16060	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K7887_16065	COG0363	glucosamine-6-phosphate deaminase activity
K7887_16070	COG2188	Transcriptional regulator
K7887_16075	COG4821	SIS domain
K7887_16090	COG0697	spore germination
K7887_16105	COG1404	Belongs to the peptidase S8 family
K7887_16115	COG0681	Belongs to the peptidase S26 family
K7887_16125	COG1404	Belongs to the peptidase S8 family
K7887_16130	COG1404	Belongs to the peptidase S8 family
K7887_16135	COG1404	Belongs to the peptidase S8 family
K7887_16140	COG1404	Belongs to the peptidase S8 family
K7887_16145	COG4974	Belongs to the 'phage' integrase family
K7887_16225	COG4473	ABC transporter
K7887_16230	COG0572	uridine kinase
K7887_16250	COG2211	Major facilitator Superfamily
K7887_16270	COG1247	-acetyltransferase
K7887_16325	COG5002	protein histidine kinase activity
K7887_16330	COG0745	RESPONSE REGULATOR receiver
K7887_16360	COG1388	LysM domain
K7887_16365	COG0739	heme binding
K7887_16370	COG0860	N-Acetylmuramoyl-L-alanine amidase
K7887_16375	COG0534	Mate efflux family protein
K7887_16380	COG0534	Mate efflux family protein
K7887_16400	COG4990	cell redox homeostasis
K7887_16405	COG0398	Pfam SNARE associated Golgi protein
K7887_16410	COG3326	Membrane
K7887_16420	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K7887_16425	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K7887_16430	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K7887_16440	COG1597	lipid kinase activity
K7887_16445	COG3611	Membrane attachment protein
K7887_16450	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K7887_16460	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K7887_16465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K7887_16475	COG1971	Probably functions as a manganese efflux pump
K7887_16480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K7887_16485	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K7887_16485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K7887_16490	COG0330	HflC and HflK could
K7887_16500	COG5002	protein histidine kinase activity
K7887_16505	COG0745	RESPONSE REGULATOR receiver
K7887_16515	COG0039	L-malate dehydrogenase activity
K7887_16520	COG0538	isocitrate dehydrogenase activity
K7887_16525	COG0372	Belongs to the citrate synthase family
K7887_16530	COG2707	UPF0756 membrane protein
K7887_16535	COG0628	permease
K7887_16575	COG4086	secreted protein
K7887_16580	COG3030	protein affecting phage T7 exclusion by the F plasmid
K7887_16590	COG0205	6-phosphofructokinase activity
K7887_16595	COG0825	malonyl-CoA metabolic process
K7887_16600	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K7887_16605	COG2186	Transcriptional regulator
K7887_16610	COG0281	malic enzyme
K7887_16615	COG0587	DNA-directed DNA polymerase activity
K7887_16630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K7887_16645	COG4109	DRTGG domain
K7887_16660	COG0006	proline dipeptidase activity
K7887_16670	COG1028	Short-chain dehydrogenase reductase Sdr
K7887_16695	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K7887_16700	COG0827	DNA restriction-modification system
K7887_16705	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K7887_16710	COG3874	Sporulation protein YtfJ
K7887_16720	COG1714	RDD family
K7887_16725	COG0616	signal peptide processing
K7887_16730	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K7887_16735	COG1574	metal-dependent hydrolase with the TIM-barrel fold
K7887_16740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K7887_16750	COG0301	tRNA thio-modification
K7887_16755	COG1104	cysteine desulfurase activity
K7887_16760	COG1114	Component of the transport system for branched-chain amino acids
K7887_16770	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
K7887_16775	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K7887_16780	COG1309	transcriptional regulator
K7887_16785	COG1956	GAF domain-containing protein
K7887_16790	COG0626	cystathionine gamma-synthase activity
K7887_16795	COG2199	diguanylate cyclase activity
K7887_16795	COG2203	Gaf domain
K7887_16805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K7887_16810	COG0456	acetyltransferase
K7887_16815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K7887_16825	COG2814	Major facilitator Superfamily
K7887_16830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K7887_16835	COG0454	-acetyltransferase
K7887_16840	COG0517	IMP dehydrogenase activity
K7887_16845	COG0123	including yeast histone deacetylase and acetoin utilization protein
K7887_16855	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K7887_16865	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K7887_16865	COG1605	Chorismate mutase
K7887_16870	COG0849	cell division
K7887_16875	COG3118	belongs to the thioredoxin family
K7887_16880	COG4980	gas vesicle protein
K7887_16885	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
K7887_16890	COG2309	aminopeptidase activity
K7887_16895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K7887_16905	COG1674	ftsk spoiiie
K7887_16905	COG1674	ftsk spoiiie
K7887_16910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K7887_16915	COG4848	Belongs to the UPF0354 family
K7887_16920	COG4412	M6 family metalloprotease domain protein
K7887_16920	COG1404	Belongs to the peptidase S8 family
K7887_16925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7887_16935	COG0840	transmembrane signaling receptor activity
K7887_16950	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K7887_16955	COG1363	Peptidase, m42
K7887_16965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K7887_16970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K7887_16980	COG0510	thiamine kinase activity
K7887_16985	COG1523	belongs to the glycosyl hydrolase 13 family
K7887_16995	COG1346	cytolysis
K7887_17000	COG1380	Effector of murein hydrolase LrgA
K7887_17010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K7887_17020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K7887_17030	COG1131	(ABC) transporter
K7887_17035	COG1349	DNA-binding transcription factor activity
K7887_17040	COG1187	pseudouridine synthase activity
K7887_17045	COG2244	polysaccharide biosynthetic process
K7887_17055	COG2081	HI0933 family
K7887_17085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K7887_17090	COG0495	leucyl-tRNA aminoacylation
K7887_17105	COG1028	Short-chain dehydrogenase reductase Sdr
K7887_17110	COG2610	gluconate transmembrane transporter activity
K7887_17115	COG3829	transcription factor binding
K7887_17115	COG3290	protein histidine kinase activity
K7887_17200	COG0326	Molecular chaperone. Has ATPase activity
K7887_17205	COG2814	Major facilitator Superfamily
K7887_17220	COG1242	4 iron, 4 sulfur cluster binding
K7887_17225	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K7887_17235	COG2267	carboxylic ester hydrolase activity
K7887_17240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K7887_17245	COG0671	phosphoesterase, PA-phosphatase related
K7887_17250	COG0438	transferase activity, transferring glycosyl groups
K7887_17255	COG0488	(ABC) transporter
K7887_17260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K7887_17265	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K7887_17270	COG1506	peptidase
K7887_17275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K7887_17280	COG1116	anion transmembrane transporter activity
K7887_17285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K7887_17290	COG0494	nUDIX hydrolase
K7887_17300	COG4824	toxin secretion phage lysis holin
K7887_17310	COG0783	Belongs to the Dps family
K7887_17325	COG0701	Predicted permease
K7887_17335	COG0534	Mate efflux family protein
K7887_17345	COG1854	S-ribosylhomocysteine lyase activity
K7887_17350	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K7887_17355	COG0288	reversible hydration of carbon dioxide
K7887_17360	COG0523	cobalamin synthesis protein
K7887_17370	COG0523	cobalamin synthesis protein
K7887_17375	COG1271	oxidase subunit
K7887_17380	COG1294	oxidase, subunit
K7887_17395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K7887_17400	COG1321	iron dependent repressor
K7887_17400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K7887_17405	COG1121	(ABC) transporter
K7887_17410	COG0803	Belongs to the bacterial solute-binding protein 9 family
K7887_17415	COG4948	Mandelate Racemase Muconate Lactonizing
K7887_17420	COG0318	PFAM AMP-dependent synthetase and ligase
K7887_17425	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K7887_17430	COG0596	Alpha beta hydrolase
K7887_17435	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K7887_17440	COG1169	isochorismate synthase
K7887_17445	COG1575	Belongs to the MenA family. Type 1 subfamily
K7887_17450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K7887_17465	COG0058	SHG alpha-glucan phosphorylase activity
K7887_17470	COG0297	glycogen (starch) synthase activity
K7887_17475	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K7887_17480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K7887_17615	COG3859	Proton-coupled thiamine transporter YuaJ
K7887_17625	COG0697	spore germination
K7887_17630	COG1285	pathogenesis
K7887_17640	COG4572	Cation transport regulator
K7887_17645	COG3023	N-Acetylmuramoyl-L-alanine amidase
K7887_17660	COG2197	response regulator
K7887_17665	COG4585	Histidine kinase
K7887_17675	COG1842	Phage shock protein A
K7887_17685	COG1404	Belongs to the peptidase S8 family
K7887_17700	COG3314	Sporulation integral membrane protein YlbJ
K7887_17705	COG0513	Belongs to the DEAD box helicase family
K7887_17710	COG1408	metallophosphoesterase
K7887_17720	COG2814	Major facilitator Superfamily
K7887_17740	COG3279	Response regulator of the LytR AlgR family
K7887_17745	COG2205	protein histidine kinase activity
K7887_17750	COG3243	poly(R)-hydroxyalkanoic acid synthase
K7887_17765	COG1278	Cold shock
K7887_17770	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K7887_17790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K7887_17810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K7887_17810	COG2111	Na H antiporter
K7887_17815	COG2111	Na H antiporter
K7887_17820	COG1006	Multisubunit Na H antiporter MnhC subunit
K7887_17825	COG0651	ATP synthesis coupled electron transport
K7887_17830	COG1863	multisubunit Na H antiporter MnhE subunit
K7887_17835	COG2212	antiporter activity
K7887_17840	COG1320	monovalent cation:proton antiporter activity
K7887_17845	COG1979	alcohol dehydrogenase
K7887_17850	COG2155	Conserved Protein
K7887_17855	COG1098	S1 RNA binding domain
K7887_17865	COG0436	Aminotransferase
K7887_17870	COG1522	sequence-specific DNA binding
K7887_17875	COG2267	carboxylic ester hydrolase activity
K7887_17885	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K7887_17890	COG0588	phosphoglycerate mutase activity
K7887_17895	COG2032	superoxide dismutase activity
K7887_17905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K7887_17915	COG5018	Exonuclease
K7887_17920	COG2814	Major facilitator Superfamily
K7887_17930	COG2050	protein possibly involved in aromatic compounds catabolism
K7887_17935	COG0640	Transcriptional regulator
K7887_17945	COG1028	Short-chain dehydrogenase reductase Sdr
K7887_17960	COG5520	Belongs to the glycosyl hydrolase 30 family
K7887_17965	COG2723	6-phospho-beta-galactosidase activity
K7887_17970	COG0395	ABC-type sugar transport system, permease component
K7887_17985	COG1609	Transcriptional regulator
K7887_17990	COG1131	(ABC) transporter
K7887_18000	COG1595	DNA-templated transcription, initiation
K7887_18010	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K7887_18015	COG0772	Belongs to the SEDS family
K7887_18020	COG0772	Belongs to the SEDS family
K7887_18030	COG1268	BioY protein
K7887_18035	COG2056	Na+-H+ antiporter family
K7887_18040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K7887_18045	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
K7887_18055	COG3584	3D domain protein
K7887_18075	COG1252	NADH dehydrogenase
K7887_18095	COG0316	Belongs to the HesB IscA family
K7887_18100	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K7887_18105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K7887_18115	COG4844	belongs to the
K7887_18120	COG1252	NADH dehydrogenase
K7887_18125	COG4837	Protein of unknown function (DUF1462)
K7887_18130	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K7887_18135	COG0083	homoserine kinase activity
K7887_18140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K7887_18145	COG0460	homoserine dehydrogenase
K7887_18150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K7887_18155	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K7887_18160	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K7887_18165	COG0647	UMP catabolic process
K7887_18170	COG2445	Protein of unknown function DUF86
K7887_18175	COG4943	cyclic-guanylate-specific phosphodiesterase activity
K7887_18190	COG4470	Protein conserved in bacteria
K7887_18200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K7887_18205	COG0739	heme binding
K7887_18215	COG0733	neurotransmitter:sodium symporter activity
K7887_18220	COG1757	Na H antiporter
K7887_18230	COG3377	Domain of unknown function (DUF1805)
K7887_18235	COG0737	Belongs to the 5'-nucleotidase family
K7887_18240	COG1801	Protein of unknown function DUF72
K7887_18260	COG0697	spore germination
K7887_18265	COG3655	Transcriptional regulator
K7887_18270	COG3739	integral membrane protein
K7887_18325	COG3344	reverse transcriptase
K7887_18425	COG0582	viral genome integration into host DNA
K7887_18475	COG0305	Participates in initiation and elongation during chromosome replication
K7887_18550	COG4974	Belongs to the 'phage' integrase family
K7887_18555	COG0719	Fe-S assembly protein
K7887_18560	COG0822	iron-sulfur transferase activity
K7887_18565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K7887_18570	COG0719	Fe-S assembly protein
K7887_18575	COG0396	ATPase activity
K7887_18585	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K7887_18590	COG1464	Belongs to the NlpA lipoprotein family
K7887_18595	COG2011	ABC-type metal ion transport system permease component
K7887_18600	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K7887_18605	COG1597	lipid kinase activity
K7887_18620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7887_18625	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K7887_18635	COG0509	glycine decarboxylation via glycine cleavage system
K7887_18640	COG1393	Belongs to the ArsC family
K7887_18645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K7887_18650	COG1960	acyl-CoA dehydrogenase activity
K7887_18655	COG0183	Belongs to the thiolase family
K7887_18660	COG1250	3-hydroxyacyl-CoA dehydrogenase
K7887_18660	COG1024	Enoyl-CoA hydratase
K7887_18680	COG5577	PFAM Coat F domain
K7887_18700	COG1120	ATPase activity
K7887_18705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7887_18710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7887_18715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K7887_18720	COG0737	Belongs to the 5'-nucleotidase family
K7887_18720	COG4085	toxin activity
K7887_18720	COG1525	nuclease
K7887_18730	COG1028	Short-chain dehydrogenase reductase Sdr
K7887_18735	COG0750	zinc metalloprotease
K7887_18740	COG0730	response to heat
K7887_18745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K7887_18745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K7887_18750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K7887_18750	COG0425	Belongs to the sulfur carrier protein TusA family
K7887_18765	COG2210	Belongs to the sulfur carrier protein TusA family
K7887_18770	COG0425	Belongs to the sulfur carrier protein TusA family
K7887_18775	COG1937	Protein conserved in bacteria
K7887_18795	COG0673	inositol 2-dehydrogenase activity
K7887_18805	COG1609	Transcriptional regulator
K7887_18810	COG0673	inositol 2-dehydrogenase activity
K7887_18815	COG3459	Glycosyltransferase 36 associated
K7887_18820	COG1472	Belongs to the glycosyl hydrolase 3 family
K7887_18825	COG0395	ABC-type sugar transport system, permease component
K7887_18830	COG1175	transmembrane transport
K7887_18845	COG0395	ABC-type sugar transport system, permease component
K7887_18850	COG1175	transmembrane transport
K7887_18885	COG1028	Short-chain dehydrogenase reductase Sdr
K7887_18890	COG5002	protein histidine kinase activity
K7887_18905	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K7887_18910	COG0557	exoribonuclease II activity
K7887_18915	COG1647	Serine aminopeptidase, S33
K7887_18930	COG1408	metallophosphoesterase
K7887_18940	COG1132	(ABC) transporter
K7887_18965	COG1132	(ABC) transporter
K7887_19005	COG0367	asparagine synthase
K7887_19030	COG1442	glycosyl transferase family 8
K7887_19030	COG1216	Glycosyl transferase, family 2
K7887_19040	COG0438	transferase activity, transferring glycosyl groups
K7887_19055	COG0438	transferase activity, transferring glycosyl groups
K7887_19060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K7887_19065	COG0110	maltose O-acetyltransferase activity
K7887_19070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K7887_19085	COG1215	transferase activity, transferring glycosyl groups
K7887_19090	COG0438	transferase activity, transferring glycosyl groups
K7887_19095	COG0438	transferase activity, transferring glycosyl groups
K7887_19100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K7887_19105	COG1086	Polysaccharide biosynthesis protein
K7887_19110	COG0489	protein tyrosine kinase activity
K7887_19115	COG3944	biosynthesis protein
K7887_19125	COG1396	sequence-specific DNA binding
K7887_19140	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K7887_19145	COG0148	phosphopyruvate hydratase activity
K7887_19150	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K7887_19155	COG0149	triose-phosphate isomerase activity
K7887_19170	COG2390	Transcriptional regulator
K7887_19180	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K7887_19190	COG0740	serine-type endopeptidase activity
K7887_19195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K7887_19200	COG1481	regulation of sporulation
K7887_19205	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K7887_19210	COG1660	Displays ATPase and GTPase activities
K7887_19215	COG1051	belongs to the nudix hydrolase family
K7887_19220	COG0492	ferredoxin-NADP+ reductase activity
K7887_19225	COG0457	Tetratricopeptide repeat
K7887_19230	COG0140	phosphoribosyl-ATP diphosphatase activity
K7887_19230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K7887_19235	COG0107	imidazoleglycerol-phosphate synthase activity
K7887_19245	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K7887_19250	COG0131	Imidazoleglycerol-phosphate dehydratase
K7887_19255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K7887_19265	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K7887_19270	COG0110	maltose O-acetyltransferase activity
K7887_19275	COG0546	phosphoglycolate phosphatase activity
K7887_19280	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K7887_19290	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K7887_19295	COG1950	PFAM Membrane protein of
K7887_19305	COG3595	metallopeptidase activity
K7887_19315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K7887_19320	COG0556	nucleotide-excision repair
K7887_19330	COG4897	Protein conserved in bacteria
K7887_19340	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K7887_19350	COG1070	Carbohydrate kinase
K7887_19355	COG2610	gluconate transmembrane transporter activity
K7887_19360	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K7887_19365	COG1737	Transcriptional regulator
K7887_19375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K7887_19380	COG3409	Peptidoglycan-binding domain 1 protein
K7887_19380	COG0793	Belongs to the peptidase S41A family
K7887_19385	COG0739	heme binding
K7887_19390	COG2177	Part of the ABC transporter FtsEX involved in
K7887_19395	COG2884	Cell division ATP-binding protein ftsE
K7887_19400	COG1404	Belongs to the peptidase S8 family
K7887_19405	COG2010	Cytochrome c
K7887_19410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K7887_19420	COG0653	protein targeting
K7887_19425	COG0860	N-Acetylmuramoyl-L-alanine amidase
K7887_19425	COG2247	cell wall binding repeat
K7887_19435	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K7887_19450	COG1516	flagellar protein fliS
K7887_19455	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K7887_19460	COG1334	flagellar protein FlaG
K7887_19480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K7887_19485	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K7887_19490	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
K7887_19500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K7887_19505	COG1256	bacterial-type flagellum assembly
K7887_19505	COG4786	Flagellar basal body rod
K7887_19525	COG1040	competence protein
K7887_19530	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K7887_19535	COG1307	EDD domain protein, DegV family
K7887_19540	COG2197	response regulator
K7887_19545	COG4585	Histidine kinase
K7887_19550	COG1739	Uncharacterized protein family UPF0029
K7887_19555	COG1316	TRANSCRIPTIONal
K7887_19560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K7887_19570	COG1215	transferase activity, transferring glycosyl groups
K7887_19580	COG2247	cell wall binding repeat
K7887_19580	COG2385	sporulation resulting in formation of a cellular spore
K7887_19590	COG0860	N-Acetylmuramoyl-L-alanine amidase
K7887_19610	COG0363	glucosamine-6-phosphate deaminase activity
K7887_19615	COG1388	LysM domain
K7887_19615	COG0791	NLP P60 protein
K7887_19630	COG2247	cell wall binding repeat
K7887_19630	COG0860	N-Acetylmuramoyl-L-alanine amidase
K7887_19635	COG2340	Cysteine-rich secretory protein family
K7887_19650	COG1316	TRANSCRIPTIONal
K7887_19660	COG4464	protein tyrosine phosphatase activity
K7887_19665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K7887_19670	COG1215	transferase activity, transferring glycosyl groups
K7887_19680	COG3307	-O-antigen
K7887_19685	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K7887_19690	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K7887_19695	COG0438	transferase activity, transferring glycosyl groups
K7887_19695	COG0297	glycogen (starch) synthase activity
K7887_19700	COG2244	polysaccharide biosynthetic process
K7887_19705	COG2247	cell wall binding repeat
K7887_19705	COG0860	N-Acetylmuramoyl-L-alanine amidase
K7887_19710	COG2247	cell wall binding repeat
K7887_19710	COG2385	sporulation resulting in formation of a cellular spore
K7887_19730	COG3764	Sortase (surface protein transpeptidase)
K7887_19740	COG0860	N-Acetylmuramoyl-L-alanine amidase
K7887_19755	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K7887_19775	COG0629	single-stranded DNA binding
K7887_19785	COG3764	Sortase (surface protein transpeptidase)
K7887_19795	COG3012	SEC-C Motif Domain Protein
K7887_19795	COG1405	negative regulation of cell septum assembly
K7887_19810	COG1482	cell wall glycoprotein biosynthetic process
K7887_19825	COG1940	carbohydrate kinase activity
K7887_19835	COG0383	alpha-mannosidase activity
K7887_19840	COG0395	ABC-type sugar transport system, permease component
K7887_19845	COG1175	transmembrane transport
K7887_19850	COG1940	carbohydrate kinase activity
K7887_19855	COG1737	Transcriptional regulator
K7887_19860	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
K7887_19870	COG2382	esterase
K7887_19890	COG0673	inositol 2-dehydrogenase activity
K7887_19900	COG2972	Histidine kinase
K7887_19925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K7887_19935	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
K7887_19940	COG0438	transferase activity, transferring glycosyl groups
K7887_19945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K7887_19960	COG0697	spore germination
K7887_19965	COG0366	Alpha amylase catalytic
K7887_19980	COG0346	lactoylglutathione lyase activity
K7887_20015	COG2962	Rard protein
K7887_20035	COG1595	DNA-templated transcription, initiation
K7887_20070	COG2076	Multidrug Resistance protein
K7887_20075	COG2076	Multidrug Resistance protein
K7887_20080	COG1309	transcriptional regulator
K7887_20095	COG0697	spore germination
K7887_20105	COG0583	DNA-binding transcription factor activity
K7887_20110	COG1619	proteins homologs of microcin C7 resistance protein MccF
K7887_20120	COG3012	SEC-C Motif Domain Protein
K7887_20125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7887_20130	COG1309	transcriptional regulator
K7887_20135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7887_20140	COG1621	beta-fructofuranosidase activity
K7887_20145	COG1653	transport
K7887_20150	COG0395	ABC-type sugar transport system, permease component
K7887_20155	COG4209	transmembrane transport
K7887_20160	COG5578	integral membrane protein
K7887_20165	COG1653	transport
K7887_20170	COG2207	Transcriptional regulator
K7887_20170	COG4753	response regulator
K7887_20195	COG0861	Integral membrane protein TerC family
K7887_20205	COG0693	protein deglycase activity
K7887_20250	COG0860	N-Acetylmuramoyl-L-alanine amidase
K7887_20250	COG2247	cell wall binding repeat
K7887_20255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K7887_20260	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K7887_20295	COG0463	Glycosyl transferase, family 2
K7887_20295	COG1216	Glycosyl transferase, family 2
K7887_20310	COG1086	Polysaccharide biosynthesis protein
K7887_20325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K7887_20330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K7887_20340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K7887_20345	COG1086	Polysaccharide biosynthesis protein
K7887_20350	COG0489	protein tyrosine kinase activity
K7887_20355	COG3944	biosynthesis protein
K7887_20375	COG4786	Flagellar basal body rod
K7887_20380	COG4786	Flagellar basal body rod
K7887_20390	COG1077	Cell shape determining protein MreB Mrl
K7887_20395	COG1609	Transcriptional regulator
K7887_20420	COG1131	(ABC) transporter
K7887_20440	COG2176	DNA-directed DNA polymerase activity
K7887_20440	COG5002	protein histidine kinase activity
K7887_20450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K7887_20470	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K7887_20475	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K7887_20480	COG2059	Chromate
K7887_20485	COG2059	Chromate
K7887_20490	COG0405	Gamma-glutamyltransferase
K7887_20510	COG0739	heme binding
K7887_20515	COG2385	sporulation resulting in formation of a cellular spore
K7887_20520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K7887_20530	COG4836	Membrane
K7887_20535	COG1007	ATP synthesis coupled electron transport
K7887_20540	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7887_20545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K7887_20550	COG0713	ATP synthesis coupled electron transport
K7887_20555	COG0839	Belongs to the complex I subunit 6 family
K7887_20575	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7887_20580	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7887_20600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K7887_20605	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K7887_20610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K7887_20615	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K7887_20620	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K7887_20625	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K7887_20630	COG0356	it plays a direct role in the translocation of protons across the membrane
K7887_20645	COG1404	Belongs to the peptidase S8 family
K7887_20650	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K7887_20665	COG0698	ribose 5-phosphate isomerase
K7887_20670	COG0840	transmembrane signaling receptor activity
K7887_20680	COG1971	Probably functions as a manganese efflux pump
K7887_20685	COG0009	L-threonylcarbamoyladenylate synthase
K7887_20705	COG2890	protein-(glutamine-N5) methyltransferase activity
K7887_20710	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K7887_20720	COG1435	thymidine kinase activity
K7887_20730	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K7887_20735	COG1494	fructose-1,6-bisphosphatase
K7887_20740	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K7887_20745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K7887_20750	COG0191	fructose-bisphosphate aldolase activity
K7887_20755	COG2204	response regulator
K7887_20760	COG4821	SIS domain
K7887_20775	COG0504	CTP synthase activity
K7887_20785	COG1703	isobutyryl-CoA mutase activity
K7887_20785	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K7887_20785	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K7887_20790	COG3226	Transcriptional regulator
K7887_20795	COG1960	acyl-CoA dehydrogenase activity
K7887_20800	COG1960	acyl-CoA dehydrogenase activity
K7887_20805	COG1250	3-hydroxyacyl-CoA dehydrogenase
K7887_20810	COG0183	Belongs to the thiolase family
K7887_20815	COG2181	nitrate reductase activity
K7887_20815	COG0247	lactate metabolic process
K7887_20820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K7887_20825	COG4294	response to UV
K7887_20835	COG0018	arginyl-trna synthetase
K7887_20845	COG0010	Belongs to the arginase family
K7887_20850	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K7887_20855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K7887_20875	COG3465	dGTPase activity
K7887_20880	COG1078	dGTPase activity
K7887_20885	COG4844	belongs to the
K7887_20900	COG0280	phosphate acetyltransferase
K7887_20905	COG3253	May function as heme-dependent peroxidase
K7887_20915	COG2363	Small membrane protein
K7887_20930	COG2322	membrane
K7887_20940	COG0840	transmembrane signaling receptor activity
K7887_20955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K7887_20960	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
K7887_20965	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K7887_20980	COG2261	transglycosylase associated protein
K7887_20995	COG0778	Nitroreductase
K7887_21005	COG1511	domain protein
K7887_21005	COG0842	Transport permease protein
K7887_21010	COG1131	(ABC) transporter
K7887_21015	COG2031	fatty acid transporter
K7887_21020	COG1621	beta-fructofuranosidase activity
K7887_21025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7887_21030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K7887_21030	COG1263	PTS System
K7887_21035	COG3711	transcriptional antiterminator
K7887_21040	COG2190	(PTS) system
K7887_21045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K7887_21045	COG3153	acetyltransferase
K7887_21055	COG0561	phosphatase activity
K7887_21065	COG3314	Sporulation integral membrane protein YlbJ
K7887_21095	COG2190	(PTS) system
K7887_21095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K7887_21095	COG1263	PTS System
K7887_21110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K7887_21110	COG0551	DNA topoisomerase type I activity
K7887_21115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K7887_21125	COG3480	Lon protease (S16) C-terminal proteolytic domain
K7887_21130	COG0488	(ABC) transporter
K7887_21155	COG2205	protein histidine kinase activity
K7887_21160	COG0745	RESPONSE REGULATOR receiver
K7887_21175	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K7887_21180	COG2234	aminopeptidase activity
K7887_21210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K7887_21250	COG0753	catalase activity
K7887_21260	COG1175	transmembrane transport
K7887_21265	COG1653	transport
K7887_21270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K7887_21275	COG1737	Transcriptional regulator
K7887_21295	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K7887_21300	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
K7887_21310	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
K7887_21315	COG0698	ribose 5-phosphate isomerase
K7887_21345	COG4869	propanediol catabolic process
K7887_21350	COG2390	Transcriptional regulator
K7887_21355	COG1079	Belongs to the binding-protein-dependent transport system permease family
K7887_21360	COG4603	Belongs to the binding-protein-dependent transport system permease family
K7887_21365	COG3845	ABC transporter
K7887_21370	COG1744	ABC transporter substrate-binding protein PnrA-like
K7887_21375	COG1187	pseudouridine synthase activity
K7887_21380	COG3842	ATPase activity
K7887_21385	COG1176	ABC-type spermidine putrescine transport system, permease component I
K7887_21395	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K7887_21400	COG0745	RESPONSE REGULATOR receiver
K7887_21405	COG2205	protein histidine kinase activity
K7887_21410	COG1136	(ABC) transporter
K7887_21415	COG0577	efflux transmembrane transporter activity
K7887_21420	COG1216	Glycosyl transferase, family 2
K7887_21425	COG1120	ATPase activity
K7887_21430	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K7887_21435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7887_21440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7887_21455	COG1840	ABC-type Fe3 transport system, periplasmic component
K7887_21460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K7887_21500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K7887_21505	COG2358	TRAP transporter, solute receptor (TAXI family
K7887_21525	COG1984	allophanate hydrolase subunit 2
K7887_21530	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K7887_21535	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K7887_21540	COG1914	H( )-stimulated, divalent metal cation uptake system
K7887_21545	COG2801	Transposase and inactivated derivatives
K7887_21555	COG1307	EDD domain protein, DegV family
K7887_21565	COG1741	Belongs to the pirin family
K7887_21570	COG0579	oxidoreductase
K7887_21575	COG4682	membrane
K7887_21600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K7887_21605	COG3706	GGDEF domain
K7887_21610	COG0697	spore germination
K7887_21620	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K7887_21625	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K7887_21625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K7887_21660	COG2011	ABC-type metal ion transport system permease component
K7887_21670	COG1464	Belongs to the NlpA lipoprotein family
K7887_21675	COG0371	Dehydrogenase
K7887_21705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K7887_21710	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K7887_21715	COG4853	Protein conserved in bacteria
K7887_21720	COG4863	YycH protein
K7887_21725	COG5002	protein histidine kinase activity
K7887_21730	COG0745	RESPONSE REGULATOR receiver
K7887_21735	COG0741	lytic transglycosylase activity
K7887_21735	COG1196	nuclear chromosome segregation
K7887_21735	COG0739	heme binding
K7887_21760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K7887_21765	COG0305	Participates in initiation and elongation during chromosome replication
K7887_21770	COG0359	binds to the 23S rRNA
K7887_21775	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
K7887_21780	COG4241	membrane
K7887_21785	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K7887_21795	COG0360	Binds together with S18 to 16S ribosomal RNA
K7887_21800	COG0012	GTP binding
K7887_21805	COG4481	Protein conserved in bacteria
K7887_21810	COG0668	transmembrane transport
K7887_21815	COG3949	Membrane
K7887_21825	COG1811	Na channel or pump
K7887_21830	COG1475	DNA binding
K7887_21835	COG1192	Involved in chromosome partitioning
K7887_21840	COG1475	DNA binding
K7887_21850	COG0445	tRNA wobble uridine modification
K7887_21855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K7887_21860	COG1847	R3H domain protein
K7887_21910	COG2002	toxin-antitoxin pair type II binding
K7887_22005	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K7887_22070	COG2333	competence protein COMEC
K7887_22070	COG0658	competence protein
K7887_22120	COG0037	tRNA processing
K7887_22175	COG1923	regulation of RNA biosynthetic process
K7887_22235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K7887_22240	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K7887_22245	COG1999	signal sequence binding
K7887_22250	COG2072	flavoprotein involved in K transport
K7887_22255	COG0640	Transcriptional regulator
K7887_22280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K7887_22315	COG0785	Cytochrome C biogenesis protein
K7887_22320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7887_22335	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K7887_22335	COG0551	DNA topoisomerase type I activity
K7887_22380	COG5290	Psort location Cytoplasmic, score
K7887_22405	COG0629	single-stranded DNA binding
K7887_22565	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K7887_22625	COG0592	DNA-directed DNA polymerase activity
K7887_22630	COG4712	double-strand break repair protein
K7887_22690	COG0739	heme binding
K7887_22710	COG5001	Diguanylate cyclase
K7887_22710	COG3300	MHYT domain
K7887_22715	COG1793	dna ligase
K7887_22725	COG2003	Belongs to the UPF0758 family
K7887_22740	COG0653	protein targeting
K7887_22805	COG3621	Patatin-like phospholipase
K7887_22825	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K7887_22845	COG2002	toxin-antitoxin pair type II binding