locus-tag	class	description
O1A01_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O1A01_00010	COG0592	DNA-directed DNA polymerase activity
O1A01_00015	COG2501	S4 domain
O1A01_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O1A01_00030	COG0187	DNA topoisomerase II activity
O1A01_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O1A01_00040	COG2199	diguanylate cyclase activity
O1A01_00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
O1A01_00075	COG0516	GMP reductase activity
O1A01_00075	COG0517	IMP dehydrogenase activity
O1A01_00085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
O1A01_00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
O1A01_00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O1A01_00105	COG1428	Deoxynucleoside kinase
O1A01_00110	COG1428	Deoxynucleoside kinase
O1A01_00115	COG1335	isochorismatase
O1A01_00120	COG0590	tRNA wobble adenosine to inosine editing
O1A01_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
O1A01_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
O1A01_00185	COG1982	Orn Lys Arg decarboxylase major
O1A01_00190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
O1A01_00195	COG3870	Protein conserved in bacteria
O1A01_00200	COG1728	Protein conserved in bacteria
O1A01_00205	COG0470	DNA polymerase III
O1A01_00210	COG1774	PSP1 C-terminal conserved region
O1A01_00215	COG4467	Involved in initiation control of chromosome replication
O1A01_00220	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
O1A01_00225	COG2827	Endonuclease containing a URI domain
O1A01_00230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
O1A01_00235	COG2002	toxin-antitoxin pair type II binding
O1A01_00245	COG0084	hydrolase, TatD family'
O1A01_00250	COG3584	3D domain protein
O1A01_00250	COG3583	domain protein
O1A01_00255	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
O1A01_00260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O1A01_00270	COG4466	Protein conserved in bacteria
O1A01_00280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
O1A01_00285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O1A01_00290	COG0251	oxidation-reduction process
O1A01_00300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
O1A01_00310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
O1A01_00315	COG3547	Transposase (IS116 IS110 IS902 family)
O1A01_00330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
O1A01_00335	COG2002	toxin-antitoxin pair type II binding
O1A01_00340	COG2244	polysaccharide biosynthetic process
O1A01_00345	COG3956	TIGRFAM MazG family protein
O1A01_00350	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
O1A01_00370	COG1098	S1 RNA binding domain
O1A01_00385	COG2208	phosphoserine phosphatase activity
O1A01_00390	COG2304	oxidoreductase activity
O1A01_00395	COG0515	serine threonine protein kinase
O1A01_00405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
O1A01_00410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O1A01_00415	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
O1A01_00420	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
O1A01_00425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O1A01_00430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O1A01_00435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O1A01_00440	COG0512	Glutamine amidotransferase of anthranilate synthase
O1A01_00445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O1A01_00450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O1A01_00455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
O1A01_00460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O1A01_00465	COG1396	sequence-specific DNA binding
O1A01_00470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O1A01_00560	COG3880	PFAM UvrB UvrC protein
O1A01_00565	COG3869	Catalyzes the specific phosphorylation of arginine residues in
O1A01_00570	COG0542	response to heat
O1A01_00580	COG4974	Belongs to the 'phage' integrase family
O1A01_00600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
O1A01_00630	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
O1A01_00635	COG0732	type I restriction modification DNA specificity domain
O1A01_00640	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
O1A01_00665	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
O1A01_00670	COG4956	integral membrane protein (PIN domain superfamily)
O1A01_00675	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O1A01_00680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
O1A01_00685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O1A01_00690	COG1045	serine acetyltransferase
O1A01_00695	COG0215	cysteine-tRNA ligase activity
O1A01_00705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O1A01_00710	COG3688	RNA-binding protein containing a PIN domain
O1A01_00720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
O1A01_00725	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O1A01_00730	COG0250	Participates in transcription elongation, termination and antitermination
O1A01_00735	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
O1A01_00740	COG0081	regulation of translation
O1A01_00745	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
O1A01_00750	COG0222	ribosome binding
O1A01_00755	COG2813	Specifically methylates the guanine in position
O1A01_00760	COG0085	RNA polymerase activity
O1A01_00770	COG1358	cellular component organization or biogenesis
O1A01_00775	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
O1A01_00785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O1A01_00790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O1A01_00795	COG0051	transcription antitermination factor activity, RNA binding
O1A01_00800	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O1A01_00805	COG0088	Forms part of the polypeptide exit tunnel
O1A01_00810	COG0089	rRNA binding
O1A01_00815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
O1A01_00820	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
O1A01_00835	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
O1A01_00840	COG0255	Belongs to the universal ribosomal protein uL29 family
O1A01_00845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
O1A01_00850	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
O1A01_00855	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
O1A01_00860	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O1A01_00865	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O1A01_00870	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O1A01_00875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
O1A01_00880	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
O1A01_00885	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
O1A01_00890	COG1841	ribosomal large subunit assembly
O1A01_00895	COG0200	Binds to the 23S rRNA
O1A01_00900	COG0201	protein transport
O1A01_00905	COG0563	adenylate kinase activity
O1A01_00910	COG0024	Methionine aminopeptidase
O1A01_00920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
O1A01_00925	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O1A01_00930	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
O1A01_00935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O1A01_00945	COG0203	ribosomal protein L17
O1A01_00950	COG1122	ATPase activity
O1A01_00960	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
O1A01_00965	COG0101	tRNA pseudouridine synthase activity
O1A01_00970	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O1A01_00975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O1A01_00980	COG1216	Glycosyl transferase, family 2
O1A01_00990	COG0655	NAD(P)H dehydrogenase (quinone) activity
O1A01_01005	COG0860	N-Acetylmuramoyl-L-alanine amidase
O1A01_01010	COG0489	protein tyrosine kinase activity
O1A01_01020	COG2194	sulfuric ester hydrolase activity
O1A01_01025	COG0726	polysaccharide deacetylase
O1A01_01095	COG1595	DNA-templated transcription, initiation
O1A01_01100	COG5662	AntiSigma factor
O1A01_01105	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
O1A01_01110	COG4856	YbbR-like protein
O1A01_01115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O1A01_01120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O1A01_01125	COG0402	S-adenosylhomocysteine deaminase activity
O1A01_01140	COG0318	PFAM AMP-dependent synthetase and ligase
O1A01_01150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O1A01_01155	COG0432	Pfam Uncharacterised protein family UPF0047
O1A01_01160	COG2002	toxin-antitoxin pair type II binding
O1A01_01170	COG1733	regulation of RNA biosynthetic process
O1A01_01175	COG2514	catechol 2,3-dioxygenase activity
O1A01_01185	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O1A01_01190	COG3973	AAA domain
O1A01_01205	COG1937	Protein conserved in bacteria
O1A01_01210	COG2608	mercury ion transmembrane transporter activity
O1A01_01215	COG2217	Heavy metal translocating P-type atpase
O1A01_01225	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O1A01_01240	COG1181	Belongs to the D-alanine--D-alanine ligase family
O1A01_01245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
O1A01_01250	COG0513	Belongs to the DEAD box helicase family
O1A01_01255	COG4294	response to UV
O1A01_01260	COG3402	PFAM membrane-flanked domain
O1A01_01265	COG3428	Bacterial PH domain
O1A01_01270	COG0705	Rhomboid family
O1A01_01275	COG0736	holo-[acyl-carrier-protein] synthase activity
O1A01_01280	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
O1A01_01285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O1A01_01290	COG0864	Transcriptional regulator
O1A01_01295	COG2337	Toxic component of a toxin-antitoxin (TA) module
O1A01_01300	COG1366	Belongs to the anti-sigma-factor antagonist family
O1A01_01305	COG1366	Belongs to the anti-sigma-factor antagonist family
O1A01_01310	COG2172	sigma factor antagonist activity
O1A01_01315	COG2208	phosphoserine phosphatase activity
O1A01_01320	COG1366	Belongs to the anti-sigma-factor antagonist family
O1A01_01325	COG2172	sigma factor antagonist activity
O1A01_01330	COG1191	sigma factor activity
O1A01_01335	COG2208	phosphoserine phosphatase activity
O1A01_01340	COG2183	response to ionizing radiation
O1A01_01350	COG3091	SprT-like family
O1A01_01440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
O1A01_01450	COG1214	PFAM Peptidase M22, glycoprotease
O1A01_01455	COG0456	acetyltransferase
O1A01_01460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O1A01_01465	COG0488	(ABC) transporter
O1A01_01470	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
O1A01_01475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O1A01_01480	COG0805	protein transport
O1A01_01490	COG1266	CAAX protease self-immunity
O1A01_01495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
O1A01_01500	COG0459	protein refolding
O1A01_01525	COG0789	Transcriptional regulator
O1A01_01530	COG1266	CAAX protease self-immunity
O1A01_01540	COG1842	Phage shock protein A
O1A01_01545	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O1A01_01550	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
O1A01_01555	COG4260	virion core protein, lumpy skin disease virus
O1A01_01560	COG1136	(ABC) transporter
O1A01_01565	COG0577	efflux transmembrane transporter activity
O1A01_01605	COG2304	oxidoreductase activity
O1A01_01655	COG0714	Associated with various cellular activities
O1A01_01660	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
O1A01_01665	COG1305	Transglutaminase-like
O1A01_01675	COG2252	PERMEase
O1A01_01740	COG0456	acetyltransferase
O1A01_01745	COG1304	FMN binding
O1A01_01750	COG2814	Major facilitator Superfamily
O1A01_01755	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
O1A01_01760	COG1131	(ABC) transporter
O1A01_01780	COG1595	DNA-templated transcription, initiation
O1A01_01790	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
O1A01_01800	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
O1A01_01805	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
O1A01_01810	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O1A01_01815	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O1A01_01820	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O1A01_01825	COG0047	phosphoribosylformylglycinamidine synthase activity
O1A01_01830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O1A01_01835	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
O1A01_01840	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O1A01_01845	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
O1A01_01855	COG0151	Belongs to the GarS family
O1A01_01865	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
O1A01_01870	COG1470	cell adhesion involved in biofilm formation
O1A01_01875	COG4496	protein, YerC YecD
O1A01_01885	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
O1A01_01890	COG0210	DNA helicase
O1A01_01895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O1A01_01900	COG4851	CamS sex pheromone cAM373 precursor
O1A01_01905	COG1012	belongs to the aldehyde dehydrogenase family
O1A01_01910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1A01_01915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1A01_01920	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O1A01_01925	COG0154	amidase activity
O1A01_01935	COG1263	PTS System
O1A01_01935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1A01_01935	COG2190	(PTS) system
O1A01_01940	COG1585	Membrane protein implicated in regulation of membrane protease activity
O1A01_01945	COG2268	Band 7 protein
O1A01_01950	COG1597	lipid kinase activity
O1A01_01960	COG1902	pentaerythritol trinitrate reductase activity
O1A01_01975	COG1733	regulation of RNA biosynthetic process
O1A01_01980	COG2514	catechol 2,3-dioxygenase activity
O1A01_01995	COG0395	ABC-type sugar transport system, permease component
O1A01_02005	COG3842	ATPase activity
O1A01_02010	COG1473	amidohydrolase
O1A01_02020	COG4948	Mandelate Racemase Muconate Lactonizing
O1A01_02025	COG3949	Membrane
O1A01_02030	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
O1A01_02035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O1A01_02040	COG4807	Protein conserved in bacteria
O1A01_02045	COG1595	DNA-templated transcription, initiation
O1A01_02070	COG0167	dihydroorotate dehydrogenase activity
O1A01_02075	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
O1A01_02100	COG2258	MOSC domain
O1A01_02105	COG3344	reverse transcriptase
O1A01_02110	COG2239	Acts as a magnesium transporter
O1A01_02145	COG1193	negative regulation of DNA recombination
O1A01_02150	COG1272	protein, Hemolysin III
O1A01_02170	COG2723	6-phospho-beta-galactosidase activity
O1A01_02180	COG1175	transmembrane transport
O1A01_02185	COG0395	ABC-type sugar transport system, permease component
O1A01_02190	COG5578	integral membrane protein
O1A01_02210	COG1595	DNA-templated transcription, initiation
O1A01_02225	COG4521	taurine ABC transporter
O1A01_02230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O1A01_02235	COG1116	anion transmembrane transporter activity
O1A01_02240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O1A01_02245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1A01_02260	COG0514	ATP-dependent DNA helicase (RecQ)
O1A01_02265	COG0745	RESPONSE REGULATOR receiver
O1A01_02285	COG1785	Belongs to the alkaline phosphatase family
O1A01_02295	COG2801	Transposase and inactivated derivatives
O1A01_02315	COG2358	TRAP transporter, solute receptor (TAXI family
O1A01_02325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_02350	COG0861	Integral membrane protein TerC family
O1A01_02365	COG0346	lactoylglutathione lyase activity
O1A01_02370	COG1027	Aspartate ammonia-lyase
O1A01_02380	COG2076	Multidrug Resistance protein
O1A01_02390	COG1309	transcriptional regulator
O1A01_02440	COG1695	Transcriptional regulator
O1A01_02460	COG2409	Drug exporters of the RND superfamily
O1A01_02470	COG4895	conserved protein (DUF2196)
O1A01_02480	COG2502	aspartate--ammonia ligase
O1A01_02500	COG1408	metallophosphoesterase
O1A01_02505	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
O1A01_02505	COG4451	ribulose bisphosphate carboxylase, small
O1A01_02510	COG0745	RESPONSE REGULATOR receiver
O1A01_02515	COG5002	protein histidine kinase activity
O1A01_02520	COG1136	(ABC) transporter
O1A01_02530	COG4175	Glycine betaine
O1A01_02530	COG0517	IMP dehydrogenase activity
O1A01_02545	COG1737	Transcriptional regulator
O1A01_02550	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
O1A01_02555	COG2610	gluconate transmembrane transporter activity
O1A01_02560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O1A01_02565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O1A01_02570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O1A01_02575	COG1120	ATPase activity
O1A01_02580	COG0492	ferredoxin-NADP+ reductase activity
O1A01_02585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O1A01_02590	COG0390	transport system, permease component
O1A01_02605	COG1183	phosphatidylcholine synthase activity
O1A01_02615	COG1609	Transcriptional regulator
O1A01_02620	COG0166	Belongs to the GPI family
O1A01_02635	COG3173	Aminoglycoside phosphotransferase
O1A01_02640	COG0154	amidase activity
O1A01_02650	COG2368	4-hydroxyphenylacetate
O1A01_02665	COG0084	hydrolase, TatD family'
O1A01_02670	COG1132	(ABC) transporter
O1A01_02675	COG1132	(ABC) transporter
O1A01_02690	COG1115	amino acid carrier protein
O1A01_02695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O1A01_02695	COG0723	plastoquinol--plastocyanin reductase activity
O1A01_02725	COG1309	transcriptional regulator
O1A01_02730	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O1A01_02740	COG0145	ligase activity
O1A01_02745	COG2124	cytochrome p450
O1A01_02755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O1A01_02765	COG2244	polysaccharide biosynthetic process
O1A01_02775	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
O1A01_02790	COG1077	Cell shape determining protein MreB Mrl
O1A01_02810	COG2814	Major facilitator Superfamily
O1A01_02825	COG1115	amino acid carrier protein
O1A01_02840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_02850	COG1904	glucuronate isomerase
O1A01_02855	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
O1A01_02860	COG1917	Cupin 2, conserved barrel domain protein
O1A01_02860	COG2207	Transcriptional regulator
O1A01_02870	COG0673	inositol 2-dehydrogenase activity
O1A01_02875	COG0673	inositol 2-dehydrogenase activity
O1A01_02885	COG2211	Major facilitator Superfamily
O1A01_02890	COG2211	Major facilitator Superfamily
O1A01_02895	COG1940	carbohydrate kinase activity
O1A01_02905	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_02910	COG1606	tRNA processing
O1A01_02915	COG1070	Carbohydrate kinase
O1A01_02920	COG1691	(AIR) carboxylase
O1A01_02925	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
O1A01_02930	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
O1A01_02935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
O1A01_02940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O1A01_02955	COG5002	protein histidine kinase activity
O1A01_02960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O1A01_02995	COG1988	membrane-bound metal-dependent
O1A01_03005	COG4840	Belongs to the UPF0435 family
O1A01_03010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O1A01_03020	COG1295	ribonuclease BN
O1A01_03040	COG2217	Heavy metal translocating P-type atpase
O1A01_03045	COG0477	Major facilitator Superfamily
O1A01_03055	COG2364	Membrane
O1A01_03075	COG0535	radical SAM domain protein
O1A01_03155	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
O1A01_03160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O1A01_03165	COG1104	cysteine desulfurase activity
O1A01_03170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_03175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_03175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_03180	COG2814	Major facilitator Superfamily
O1A01_03185	COG1196	nuclear chromosome segregation
O1A01_03230	COG0785	Cytochrome C biogenesis protein
O1A01_03235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1A01_03240	COG0745	RESPONSE REGULATOR receiver
O1A01_03245	COG3850	Histidine kinase
O1A01_03245	COG5002	protein histidine kinase activity
O1A01_03250	COG0737	Belongs to the 5'-nucleotidase family
O1A01_03265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_03265	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_03270	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_03270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_03275	COG2210	Belongs to the sulfur carrier protein TusA family
O1A01_03280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_03280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_03285	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_03295	COG0288	reversible hydration of carbon dioxide
O1A01_03320	COG1937	Protein conserved in bacteria
O1A01_03325	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_03330	COG2210	Belongs to the sulfur carrier protein TusA family
O1A01_03340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_03345	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_03345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_03355	COG2210	Belongs to the sulfur carrier protein TusA family
O1A01_03360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_03360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_03365	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_03375	COG0662	Cupin 2, conserved barrel domain protein
O1A01_03380	COG0446	pyridine nucleotide-disulphide oxidoreductase
O1A01_03405	COG0653	protein targeting
O1A01_03415	COG0515	serine threonine protein kinase
O1A01_03480	COG3773	Cell wall hydrolase
O1A01_03495	COG0697	spore germination
O1A01_03515	COG0402	S-adenosylhomocysteine deaminase activity
O1A01_03535	COG1114	Component of the transport system for branched-chain amino acids
O1A01_03540	COG0659	secondary active sulfate transmembrane transporter activity
O1A01_03560	COG1063	alcohol dehydrogenase
O1A01_03590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O1A01_03625	COG1307	EDD domain protein, DegV family
O1A01_03650	COG0653	protein targeting
O1A01_03665	COG3290	protein histidine kinase activity
O1A01_03665	COG3829	transcription factor binding
O1A01_03675	COG1012	belongs to the aldehyde dehydrogenase family
O1A01_03680	COG0564	pseudouridine synthase activity
O1A01_03690	COG1329	Transcriptional regulator
O1A01_03700	COG1595	DNA-templated transcription, initiation
O1A01_03715	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O1A01_03720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O1A01_03735	COG0109	protoheme IX farnesyltransferase activity
O1A01_03740	COG1959	2 iron, 2 sulfur cluster binding
O1A01_03745	COG2910	NAD(P)H-binding
O1A01_03755	COG3481	metal-dependent phosphohydrolase, HD sub domain
O1A01_03765	COG2323	membrane
O1A01_03775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O1A01_03790	COG1136	(ABC) transporter
O1A01_03810	COG3620	sequence-specific DNA binding
O1A01_03830	COG2072	flavoprotein involved in K transport
O1A01_03835	COG2217	Heavy metal translocating P-type atpase
O1A01_03840	COG5001	Diguanylate cyclase
O1A01_03840	COG3300	MHYT domain
O1A01_03845	COG0697	spore germination
O1A01_03850	COG0814	amino acid
O1A01_03875	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O1A01_03880	COG0405	Gamma-glutamyltransferase
O1A01_03885	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O1A01_03895	COG0640	Transcriptional regulator
O1A01_03900	COG3832	glyoxalase III activity
O1A01_03905	COG3706	GGDEF domain
O1A01_03915	COG2323	membrane
O1A01_03920	COG0038	chloride channel
O1A01_03925	COG0569	domain protein
O1A01_03930	COG4555	ABC transporter
O1A01_03940	COG0656	L-ascorbic acid biosynthetic process
O1A01_03945	COG1131	(ABC) transporter
O1A01_03950	COG0842	Transport permease protein
O1A01_03950	COG1511	domain protein
O1A01_03960	COG1363	Peptidase, m42
O1A01_03990	COG0673	inositol 2-dehydrogenase activity
O1A01_03995	COG0673	inositol 2-dehydrogenase activity
O1A01_04020	COG2233	PERMEase
O1A01_04035	COG0840	transmembrane signaling receptor activity
O1A01_04040	COG0460	homoserine dehydrogenase
O1A01_04045	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O1A01_04050	COG0083	homoserine kinase activity
O1A01_04055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O1A01_04060	COG0129	dihydroxy-acid dehydratase activity
O1A01_04065	COG0028	Belongs to the TPP enzyme family
O1A01_04070	COG0440	acetolactate synthase activity
O1A01_04075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O1A01_04080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O1A01_04090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O1A01_04095	COG0066	3-isopropylmalate dehydratase activity
O1A01_04100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O1A01_04105	COG1404	Belongs to the peptidase S8 family
O1A01_04110	COG2208	phosphoserine phosphatase activity
O1A01_04115	COG0596	Alpha beta hydrolase
O1A01_04145	COG0686	Belongs to the AlaDH PNT family
O1A01_04150	COG2508	Transcriptional regulator
O1A01_04150	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
O1A01_04160	COG2409	Drug exporters of the RND superfamily
O1A01_04165	COG2814	Major facilitator Superfamily
O1A01_04175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
O1A01_04185	COG1595	DNA-templated transcription, initiation
O1A01_04190	COG1757	Na H antiporter
O1A01_04195	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O1A01_04210	COG3639	organic phosphonate transmembrane transporter activity
O1A01_04230	COG0395	ABC-type sugar transport system, permease component
O1A01_04235	COG1653	transport
O1A01_04245	COG0733	neurotransmitter:sodium symporter activity
O1A01_04275	COG5577	PFAM Coat F domain
O1A01_04280	COG1063	alcohol dehydrogenase
O1A01_04290	COG0427	acetyl-CoA hydrolase
O1A01_04295	COG1619	proteins homologs of microcin C7 resistance protein MccF
O1A01_04300	COG1834	amidinotransferase
O1A01_04305	COG2205	protein histidine kinase activity
O1A01_04310	COG2211	Major facilitator Superfamily
O1A01_04315	COG2329	Antibiotic biosynthesis monooxygenase
O1A01_04325	COG1280	lysine exporter protein (LysE YggA)
O1A01_04365	COG0534	Mate efflux family protein
O1A01_04370	COG1309	transcriptional regulator
O1A01_04375	COG2814	Major facilitator Superfamily
O1A01_04405	COG3279	Response regulator of the LytR AlgR family
O1A01_04410	COG4555	ABC transporter
O1A01_04415	COG1668	transmembrane transport
O1A01_04425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O1A01_04435	COG1960	acyl-CoA dehydrogenase activity
O1A01_04445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O1A01_04450	COG1846	Transcriptional regulator
O1A01_04455	COG2814	Major facilitator Superfamily
O1A01_04460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O1A01_04480	COG1757	Na H antiporter
O1A01_04505	COG1228	amidohydrolase
O1A01_04510	COG1090	epimerase
O1A01_04520	COG4221	oxidoreductase activity
O1A01_04545	COG1988	membrane-bound metal-dependent
O1A01_04550	COG1194	a g-specific adenine glycosylase
O1A01_04570	COG3557	Belongs to the UPF0374 family
O1A01_04575	COG1132	(ABC) transporter
O1A01_04580	COG4129	membrane
O1A01_04585	COG0069	glutamate synthase activity
O1A01_04585	COG0067	glutamate synthase
O1A01_04585	COG0070	glutamate synthase
O1A01_04605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O1A01_04610	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
O1A01_04615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O1A01_04620	COG2096	Adenosyltransferase
O1A01_04625	COG0735	belongs to the Fur family
O1A01_04740	COG3382	B3 4 domain protein
O1A01_04755	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
O1A01_04760	COG2766	serine protein kinase
O1A01_04765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1A01_04780	COG0747	negative chemotaxis
O1A01_04790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1A01_04795	COG0601	transmembrane transport
O1A01_04800	COG0444	Belongs to the ABC transporter superfamily
O1A01_04805	COG4608	Belongs to the ABC transporter superfamily
O1A01_04810	COG0697	spore germination
O1A01_04845	COG0372	Belongs to the citrate synthase family
O1A01_04850	COG0583	DNA-binding transcription factor activity
O1A01_04865	COG0708	Exodeoxyribonuclease III
O1A01_04870	COG4607	ABC-type enterochelin transport system periplasmic component
O1A01_04880	COG4667	esterase of the alpha-beta hydrolase superfamily
O1A01_04885	COG1164	Oligoendopeptidase f
O1A01_04890	COG4191	Histidine kinase
O1A01_04895	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O1A01_04900	COG4605	iron ion homeostasis
O1A01_04905	COG4604	ABC transporter, ATP-binding protein
O1A01_04910	COG4607	ABC-type enterochelin transport system periplasmic component
O1A01_04915	COG4536	flavin adenine dinucleotide binding
O1A01_04925	COG0840	transmembrane signaling receptor activity
O1A01_04935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O1A01_04950	COG1968	undecaprenyl-diphosphatase activity
O1A01_04955	COG2205	protein histidine kinase activity
O1A01_04965	COG0789	Transcriptional regulator
O1A01_04985	COG0564	pseudouridine synthase activity
O1A01_05000	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
O1A01_05015	COG1228	amidohydrolase
O1A01_05030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O1A01_05030	COG3153	acetyltransferase
O1A01_05035	COG0791	NLP P60 protein
O1A01_05035	COG1388	LysM domain
O1A01_05050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O1A01_05055	COG2203	Gaf domain
O1A01_05055	COG4585	Histidine kinase
O1A01_05060	COG2197	response regulator
O1A01_05065	COG0431	NADPH-dependent FMN reductase
O1A01_05085	COG2239	Acts as a magnesium transporter
O1A01_05090	COG0730	response to heat
O1A01_05095	COG2719	SpoVR family
O1A01_05130	COG0640	Transcriptional regulator
O1A01_05135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O1A01_05140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O1A01_05145	COG0154	amidase activity
O1A01_05165	COG1794	racemase activity, acting on amino acids and derivatives
O1A01_05170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O1A01_05175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
O1A01_05185	COG0398	Pfam SNARE associated Golgi protein
O1A01_05200	COG1131	(ABC) transporter
O1A01_05215	COG0582	viral genome integration into host DNA
O1A01_05225	COG0534	Mate efflux family protein
O1A01_05230	COG2814	Major facilitator Superfamily
O1A01_05240	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O1A01_05255	COG0521	Mo-molybdopterin cofactor biosynthetic process
O1A01_05260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O1A01_05275	COG0303	'Molybdopterin
O1A01_05280	COG1763	Mo-molybdopterin cofactor biosynthetic process
O1A01_05285	COG0314	molybdopterin synthase activity
O1A01_05290	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
O1A01_05315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O1A01_05320	COG0746	molybdenum cofactor guanylyltransferase activity
O1A01_05325	COG0535	radical SAM domain protein
O1A01_05330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O1A01_05335	COG0489	protein tyrosine kinase activity
O1A01_05345	COG0243	molybdopterin cofactor binding
O1A01_05350	COG0437	4 iron, 4 sulfur cluster binding
O1A01_05365	COG1686	Belongs to the peptidase S11 family
O1A01_05380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O1A01_05415	COG1078	dGTPase activity
O1A01_05420	COG0586	Pfam SNARE associated Golgi protein
O1A01_05430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O1A01_05435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O1A01_05445	COG1301	dicarboxylic acid transport
O1A01_05450	COG1970	mechanosensitive ion channel activity
O1A01_05460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O1A01_05470	COG0393	Putative heavy-metal-binding
O1A01_05475	COG3773	Cell wall hydrolase
O1A01_05490	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
O1A01_05500	COG1122	ATPase activity
O1A01_05510	COG0352	thiamine-phosphate diphosphorylase activity
O1A01_05515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O1A01_05520	COG2104	thiamine diphosphate biosynthetic process
O1A01_05525	COG2022	thiamine diphosphate biosynthetic process
O1A01_05530	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O1A01_05535	COG0351	phosphomethylpyrimidine kinase
O1A01_05545	COG4989	oxidoreductase activity
O1A01_05560	COG1607	acyl-coa hydrolase
O1A01_05575	COG1132	(ABC) transporter
O1A01_05580	COG1132	(ABC) transporter
O1A01_05585	COG1253	flavin adenine dinucleotide binding
O1A01_05600	COG3842	ATPase activity
O1A01_05605	COG2508	Transcriptional regulator
O1A01_05620	COG0189	ligase activity
O1A01_05625	COG0189	ligase activity
O1A01_05630	COG0189	ligase activity
O1A01_05635	COG0189	ligase activity
O1A01_05645	COG3679	Belongs to the UPF0342 family
O1A01_05650	COG0561	phosphatase activity
O1A01_05655	COG1131	(ABC) transporter
O1A01_05660	COG0842	Transport permease protein
O1A01_05665	COG4585	Histidine kinase
O1A01_05670	COG2197	response regulator
O1A01_05675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O1A01_05680	COG4412	M6 family metalloprotease domain protein
O1A01_05680	COG1404	Belongs to the peptidase S8 family
O1A01_05700	COG0681	Belongs to the peptidase S26 family
O1A01_05705	COG1024	Enoyl-CoA hydratase
O1A01_05715	COG0420	3'-5' exonuclease activity
O1A01_05720	COG4717	serine-type aminopeptidase activity
O1A01_05725	COG3481	metal-dependent phosphohydrolase, HD sub domain
O1A01_05735	COG2233	PERMEase
O1A01_05740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O1A01_05770	COG1846	Transcriptional regulator
O1A01_05790	COG0537	adenosine 5'-monophosphoramidase activity
O1A01_05795	COG1131	(ABC) transporter
O1A01_05800	COG4473	ABC transporter
O1A01_05810	COG1473	amidohydrolase
O1A01_05825	COG4585	Histidine kinase
O1A01_05830	COG2197	response regulator
O1A01_05835	COG2329	Antibiotic biosynthesis monooxygenase
O1A01_05840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O1A01_05845	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
O1A01_05850	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
O1A01_05855	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
O1A01_05865	COG1609	Transcriptional regulator
O1A01_05875	COG1234	tRNA 3'-trailer cleavage
O1A01_05880	COG0095	Lipoate-protein ligase
O1A01_05885	COG0318	PFAM AMP-dependent synthetase and ligase
O1A01_05890	COG1024	Enoyl-CoA hydratase
O1A01_05895	COG2199	diguanylate cyclase activity
O1A01_05895	COG2200	EAL domain
O1A01_05895	COG2202	Pas domain
O1A01_05905	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
O1A01_05915	COG1999	signal sequence binding
O1A01_05920	COG0501	Belongs to the peptidase M48B family
O1A01_05950	COG0398	Pfam SNARE associated Golgi protein
O1A01_05960	COG0183	Belongs to the thiolase family
O1A01_05975	COG0411	ABC transporter
O1A01_05985	COG0559	Belongs to the binding-protein-dependent transport system permease family
O1A01_06000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O1A01_06010	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_06015	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O1A01_06020	COG0318	PFAM AMP-dependent synthetase and ligase
O1A01_06030	COG0706	membrane insertase activity
O1A01_06035	COG2814	Major facilitator Superfamily
O1A01_06040	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
O1A01_06045	COG1074	ATP-dependent DNA helicase activity
O1A01_06050	COG0420	3'-5' exonuclease activity
O1A01_06055	COG0419	ATPase involved in DNA repair
O1A01_06060	COG1403	HNH endonuclease
O1A01_06100	COG2311	Membrane
O1A01_06110	COG0179	Fumarylacetoacetate (FAA) hydrolase
O1A01_06115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O1A01_06125	COG5001	Diguanylate cyclase
O1A01_06125	COG3300	MHYT domain
O1A01_06135	COG0367	asparagine synthase
O1A01_06140	COG0004	ammonium transporteR
O1A01_06150	COG0534	Mate efflux family protein
O1A01_06155	COG1917	Cupin 2, conserved barrel domain protein
O1A01_06155	COG2207	Transcriptional regulator
O1A01_06165	COG2182	Extracellular solute-binding protein
O1A01_06170	COG1175	transmembrane transport
O1A01_06175	COG3833	ABC-type maltose transport systems, permease component
O1A01_06180	COG0366	Alpha amylase catalytic
O1A01_06180	COG1874	Beta-galactosidase
O1A01_06185	COG1609	Transcriptional regulator
O1A01_06190	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_06200	COG1666	GTP binding
O1A01_06205	COG2996	Protein conserved in bacteria
O1A01_06215	COG1307	EDD domain protein, DegV family
O1A01_06220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O1A01_06240	COG0561	phosphatase activity
O1A01_06245	COG1073	alpha beta
O1A01_06250	COG2151	metal-sulfur cluster biosynthetic enzyme
O1A01_06260	COG0542	response to heat
O1A01_06275	COG2267	carboxylic ester hydrolase activity
O1A01_06285	COG1744	ABC transporter substrate-binding protein PnrA-like
O1A01_06300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O1A01_06305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O1A01_06310	COG5504	Zn-dependent protease
O1A01_06315	COG0444	Belongs to the ABC transporter superfamily
O1A01_06320	COG4608	Belongs to the ABC transporter superfamily
O1A01_06330	COG0601	transmembrane transport
O1A01_06335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1A01_06350	COG0180	Tryptophanyl-tRNA synthetase
O1A01_06365	COG1473	amidohydrolase
O1A01_06375	COG4166	transmembrane transport
O1A01_06380	COG0601	transmembrane transport
O1A01_06385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1A01_06390	COG0444	Belongs to the ABC transporter superfamily
O1A01_06395	COG4608	Belongs to the ABC transporter superfamily
O1A01_06410	COG0456	acetyltransferase
O1A01_06430	COG1393	Belongs to the ArsC family
O1A01_06445	COG4862	establishment of competence for transformation
O1A01_06450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O1A01_06460	COG1164	Oligoendopeptidase f
O1A01_06475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O1A01_06480	COG2346	COG2346, Truncated hemoglobins
O1A01_06485	COG0741	lytic transglycosylase activity
O1A01_06490	COG4116	CYTH
O1A01_06500	COG2357	RelA SpoT domain protein
O1A01_06510	COG0564	pseudouridine synthase activity
O1A01_06515	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O1A01_06520	COG0772	Belongs to the SEDS family
O1A01_06525	COG0475	glutathione-regulated potassium exporter activity
O1A01_06525	COG0589	response to stress
O1A01_06575	COG0438	transferase activity, transferring glycosyl groups
O1A01_06625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O1A01_06630	COG0463	Glycosyl transferase, family 2
O1A01_06680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O1A01_06695	COG2323	membrane
O1A01_06735	COG0210	DNA helicase
O1A01_06745	COG2323	membrane
O1A01_06765	COG2153	protein acetylation
O1A01_06770	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
O1A01_06775	COG2382	esterase
O1A01_06795	COG1999	signal sequence binding
O1A01_06805	COG1418	mRNA catabolic process
O1A01_06825	COG0582	viral genome integration into host DNA
O1A01_07120	COG0582	viral genome integration into host DNA
O1A01_07230	COG1484	DNA-dependent DNA replication
O1A01_07250	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
O1A01_07275	COG2201	protein-glutamate methylesterase activity
O1A01_07320	COG3677	Transposase
O1A01_07340	COG3728	DNA packaging
O1A01_07340	COG5484	DNA packaging
O1A01_07525	COG2720	vancomycin resistance protein
O1A01_07530	COG1802	Transcriptional regulator
O1A01_07540	COG0601	transmembrane transport
O1A01_07545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1A01_07555	COG1124	(ABC) transporter
O1A01_07560	COG1114	Component of the transport system for branched-chain amino acids
O1A01_07590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1A01_07600	COG3620	sequence-specific DNA binding
O1A01_07620	COG2188	Transcriptional regulator
O1A01_07625	COG1263	PTS System
O1A01_07625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1A01_07630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O1A01_07635	COG4844	belongs to the
O1A01_07665	COG2270	Major facilitator Superfamily
O1A01_07680	COG0693	protein deglycase activity
O1A01_07720	COG5002	protein histidine kinase activity
O1A01_07740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O1A01_07745	COG2146	nitrite reductase [NAD(P)H] activity
O1A01_07750	COG1587	Uroporphyrinogen-III synthase
O1A01_07750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O1A01_07755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
O1A01_07760	COG1177	transmembrane transport
O1A01_07765	COG1176	ABC-type spermidine putrescine transport system, permease component I
O1A01_07770	COG3842	ATPase activity
O1A01_07775	COG1132	(ABC) transporter
O1A01_07800	COG0789	Transcriptional regulator
O1A01_07810	COG2112	serine threonine protein kinase
O1A01_07815	COG0438	transferase activity, transferring glycosyl groups
O1A01_07825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O1A01_07830	COG4191	Histidine kinase
O1A01_07835	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
O1A01_07835	COG2105	PFAM AIG2 family protein
O1A01_07845	COG1979	alcohol dehydrogenase
O1A01_07850	COG2304	oxidoreductase activity
O1A01_07855	COG4129	membrane
O1A01_07940	COG2814	Major facilitator Superfamily
O1A01_07945	COG1595	DNA-templated transcription, initiation
O1A01_07965	COG4533	DNA binding
O1A01_07975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O1A01_07980	COG5278	phosphoserine phosphatase activity
O1A01_07980	COG0840	transmembrane signaling receptor activity
O1A01_07985	COG3340	Belongs to the peptidase S51 family
O1A01_07990	COG2207	Transcriptional regulator
O1A01_07995	COG0789	Transcriptional regulator
O1A01_08000	COG2365	Tyrosine phosphatase family
O1A01_08005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1A01_08010	COG0765	amino acid transport
O1A01_08015	COG1126	abc transporter atp-binding protein
O1A01_08030	COG1132	(ABC) transporter
O1A01_08040	COG0697	spore germination
O1A01_08045	COG0628	permease
O1A01_08080	COG0579	oxidoreductase
O1A01_08090	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O1A01_08100	COG1649	PFAM Uncharacterised BCR, COG1649
O1A01_08105	COG3773	Cell wall hydrolase
O1A01_08120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1A01_08140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O1A01_08145	COG1012	belongs to the aldehyde dehydrogenase family
O1A01_08160	COG0823	Involved in the tonB-independent uptake of proteins
O1A01_08160	COG4946	Tricorn protease homolog
O1A01_08160	COG1506	peptidase
O1A01_08165	COG1609	Transcriptional regulator
O1A01_08170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1A01_08170	COG1263	PTS System
O1A01_08175	COG1621	beta-fructofuranosidase activity
O1A01_08180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1A01_08185	COG0702	epimerase
O1A01_08195	COG0753	catalase activity
O1A01_08205	COG1396	sequence-specific DNA binding
O1A01_08215	COG0657	acetylesterase activity
O1A01_08220	COG0561	phosphatase activity
O1A01_08225	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O1A01_08230	COG0583	DNA-binding transcription factor activity
O1A01_08235	COG1595	DNA-templated transcription, initiation
O1A01_08240	COG1316	TRANSCRIPTIONal
O1A01_08245	COG0860	N-Acetylmuramoyl-L-alanine amidase
O1A01_08250	COG1595	DNA-templated transcription, initiation
O1A01_08275	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O1A01_08290	COG0405	Gamma-glutamyltransferase
O1A01_08315	COG1476	TRANSCRIPTIONal
O1A01_08345	COG3300	MHYT domain
O1A01_08345	COG5001	Diguanylate cyclase
O1A01_08355	COG1595	DNA-templated transcription, initiation
O1A01_08370	COG0450	alkyl hydroperoxide reductase
O1A01_08375	COG3634	alkyl hydroperoxide reductase activity
O1A01_08410	COG5578	integral membrane protein
O1A01_08420	COG3458	cephalosporin-C deacetylase activity
O1A01_08425	COG1737	Transcriptional regulator
O1A01_08435	COG4209	transmembrane transport
O1A01_08440	COG0395	ABC-type sugar transport system, permease component
O1A01_08445	COG1653	transport
O1A01_08460	COG1472	Belongs to the glycosyl hydrolase 3 family
O1A01_08480	COG4145	pantothenate transmembrane transporter activity
O1A01_08485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1A01_08490	COG0473	3-isopropylmalate dehydrogenase activity
O1A01_08500	COG1012	belongs to the aldehyde dehydrogenase family
O1A01_08505	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O1A01_08510	COG1522	sequence-specific DNA binding
O1A01_08520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O1A01_08525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O1A01_08530	COG0745	RESPONSE REGULATOR receiver
O1A01_08535	COG3850	Histidine kinase
O1A01_08535	COG5002	protein histidine kinase activity
O1A01_08540	COG1136	(ABC) transporter
O1A01_08550	COG0745	RESPONSE REGULATOR receiver
O1A01_08555	COG2205	protein histidine kinase activity
O1A01_08560	COG1136	(ABC) transporter
O1A01_08565	COG0577	efflux transmembrane transporter activity
O1A01_08580	COG1757	Na H antiporter
O1A01_08585	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
O1A01_08590	COG1126	abc transporter atp-binding protein
O1A01_08595	COG0765	amino acid transport
O1A01_08600	COG0765	amino acid transport
O1A01_08605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1A01_08610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O1A01_08625	COG2030	dehydratase
O1A01_08630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O1A01_08680	COG0446	pyridine nucleotide-disulphide oxidoreductase
O1A01_08705	COG1136	(ABC) transporter
O1A01_08730	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_08735	COG0668	transmembrane transport
O1A01_08740	COG2234	aminopeptidase activity
O1A01_08745	COG0477	Major facilitator Superfamily
O1A01_08780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O1A01_08785	COG1250	3-hydroxyacyl-CoA dehydrogenase
O1A01_08795	COG4948	Mandelate Racemase Muconate Lactonizing
O1A01_08800	COG1288	antiporter activity
O1A01_08810	COG1473	amidohydrolase
O1A01_08825	COG1388	LysM domain
O1A01_08825	COG0791	NLP P60 protein
O1A01_08830	COG0745	RESPONSE REGULATOR receiver
O1A01_08835	COG3850	Histidine kinase
O1A01_08835	COG5002	protein histidine kinase activity
O1A01_08845	COG0577	efflux transmembrane transporter activity
O1A01_08850	COG1136	(ABC) transporter
O1A01_08855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1A01_08865	COG0737	Belongs to the 5'-nucleotidase family
O1A01_08870	COG1191	sigma factor activity
O1A01_08890	COG1584	GPR1 FUN34 yaaH family protein
O1A01_08895	COG1657	PFAM Prenyltransferase squalene oxidase
O1A01_08920	COG2226	methyltransferase
O1A01_08930	COG2267	carboxylic ester hydrolase activity
O1A01_08950	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O1A01_08960	COG1476	TRANSCRIPTIONal
O1A01_08965	COG2207	Transcriptional regulator
O1A01_08970	COG1472	Belongs to the glycosyl hydrolase 3 family
O1A01_08990	COG3314	Sporulation integral membrane protein YlbJ
O1A01_09000	COG0702	epimerase
O1A01_09015	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
O1A01_09035	COG1115	amino acid carrier protein
O1A01_09040	COG1215	transferase activity, transferring glycosyl groups
O1A01_09045	COG1414	Transcriptional regulator
O1A01_09050	COG0531	amino acid
O1A01_09060	COG1388	LysM domain
O1A01_09060	COG0791	NLP P60 protein
O1A01_09125	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
O1A01_09140	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O1A01_09145	COG0456	acetyltransferase
O1A01_09160	COG0653	protein targeting
O1A01_09170	COG0745	RESPONSE REGULATOR receiver
O1A01_09185	COG2205	protein histidine kinase activity
O1A01_09200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1A01_09210	COG2814	Major facilitator Superfamily
O1A01_09215	COG0640	Transcriptional regulator
O1A01_09305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O1A01_09325	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_09335	COG4145	pantothenate transmembrane transporter activity
O1A01_09390	COG2197	response regulator
O1A01_09450	COG2200	EAL domain
O1A01_09455	COG3119	arylsulfatase activity
O1A01_09465	COG2746	aminoglycoside 3-N-acetyltransferase activity
O1A01_09470	COG0493	'glutamate synthase
O1A01_09525	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_09540	COG0322	excinuclease ABC activity
O1A01_09550	COG0210	DNA helicase
O1A01_09640	COG1061	Type III restriction enzyme res subunit
O1A01_09650	COG0210	DNA helicase
O1A01_09765	COG1401	restriction endodeoxyribonuclease activity
O1A01_09775	COG0583	DNA-binding transcription factor activity
O1A01_09780	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
O1A01_09795	COG0456	acetyltransferase
O1A01_09805	COG1595	DNA-templated transcription, initiation
O1A01_09825	COG1192	Involved in chromosome partitioning
O1A01_09855	COG1595	DNA-templated transcription, initiation
O1A01_09870	COG5646	InterPro IPR014922
O1A01_09875	COG2222	sugar isomerase
O1A01_09880	COG1653	transport
O1A01_09885	COG1175	transmembrane transport
O1A01_09890	COG0395	ABC-type sugar transport system, permease component
O1A01_09895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1A01_09900	COG2188	Transcriptional regulator
O1A01_09905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O1A01_09925	COG1404	Belongs to the peptidase S8 family
O1A01_09940	COG1595	DNA-templated transcription, initiation
O1A01_09955	COG1136	(ABC) transporter
O1A01_09975	COG0110	maltose O-acetyltransferase activity
O1A01_09985	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
O1A01_10025	COG0110	maltose O-acetyltransferase activity
O1A01_10060	COG2247	cell wall binding repeat
O1A01_10060	COG2385	sporulation resulting in formation of a cellular spore
O1A01_10085	COG0477	Major facilitator Superfamily
O1A01_10180	COG5504	Zn-dependent protease
O1A01_10210	COG1214	PFAM Peptidase M22, glycoprotease
O1A01_10210	COG0456	acetyltransferase
O1A01_10255	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
O1A01_10260	COG3844	kynureninase activity
O1A01_10265	COG1309	transcriptional regulator
O1A01_10275	COG0494	nUDIX hydrolase
O1A01_10280	COG0494	nUDIX hydrolase
O1A01_10295	COG0500	methyltransferase
O1A01_10295	COG3615	Tellurite resistance protein tehB
O1A01_10300	COG0681	Belongs to the peptidase S26 family
O1A01_10320	COG0154	amidase activity
O1A01_10465	COG0488	(ABC) transporter
O1A01_10470	COG2746	aminoglycoside 3-N-acetyltransferase activity
O1A01_10485	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O1A01_10520	COG1846	Transcriptional regulator
O1A01_10525	COG0456	acetyltransferase
O1A01_10530	COG2808	Putative FMN-binding domain
O1A01_10570	COG0202	RNA polymerase activity
O1A01_10610	COG0656	L-ascorbic acid biosynthetic process
O1A01_10630	COG1595	DNA-templated transcription, initiation
O1A01_10655	COG1063	alcohol dehydrogenase
O1A01_10690	COG1164	Oligoendopeptidase f
O1A01_10700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O1A01_10710	COG1595	DNA-templated transcription, initiation
O1A01_10725	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
O1A01_10735	COG0789	Transcriptional regulator
O1A01_10735	COG4978	Transcriptional regulator
O1A01_10740	COG2814	Major facilitator Superfamily
O1A01_10800	COG1309	transcriptional regulator
O1A01_10820	COG0753	catalase activity
O1A01_10825	COG0515	serine threonine protein kinase
O1A01_10825	COG1357	PFAM Pentapeptide repeats (8 copies)
O1A01_10845	COG2323	membrane
O1A01_10850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O1A01_10865	COG1595	DNA-templated transcription, initiation
O1A01_10875	COG2226	methyltransferase
O1A01_10890	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1A01_10890	COG2213	PTS system mannitol-specific
O1A01_10895	COG3711	transcriptional antiterminator
O1A01_10940	COG2135	peptidase activity
O1A01_10965	COG0778	Nitroreductase
O1A01_10970	COG0346	lactoylglutathione lyase activity
O1A01_10975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O1A01_10980	COG0346	lactoylglutathione lyase activity
O1A01_10985	COG0400	carboxylic ester hydrolase activity
O1A01_10990	COG2259	Doxx family
O1A01_11000	COG0662	Cupin 2, conserved barrel domain protein
O1A01_11005	COG0697	spore germination
O1A01_11010	COG1522	sequence-specific DNA binding
O1A01_11030	COG4149	molybdate abc transporter
O1A01_11035	COG1846	Transcriptional regulator
O1A01_11040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O1A01_11055	COG1714	RDD family
O1A01_11070	COG0596	Alpha beta hydrolase
O1A01_11080	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O1A01_11100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O1A01_11120	COG1595	DNA-templated transcription, initiation
O1A01_11150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O1A01_11160	COG4682	membrane
O1A01_11170	COG0697	spore germination
O1A01_11220	COG1051	belongs to the nudix hydrolase family
O1A01_11270	COG0596	Alpha beta hydrolase
O1A01_11275	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
O1A01_11295	COG1131	(ABC) transporter
O1A01_11310	COG0714	Associated with various cellular activities
O1A01_11330	COG2364	Membrane
O1A01_11340	COG0114	fumarate hydratase activity
O1A01_11360	COG0435	Glutathione S-transferase
O1A01_11370	COG0300	oxidoreductase activity
O1A01_11375	COG3118	belongs to the thioredoxin family
O1A01_11390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1A01_11390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1A01_11400	COG3012	SEC-C Motif Domain Protein
O1A01_11400	COG1405	negative regulation of cell septum assembly
O1A01_11405	COG0436	Aminotransferase
O1A01_11410	COG2329	Antibiotic biosynthesis monooxygenase
O1A01_11420	COG1929	Belongs to the glycerate kinase type-1 family
O1A01_11435	COG1271	oxidase subunit
O1A01_11440	COG1294	oxidase, subunit
O1A01_11445	COG4988	ABC transporter
O1A01_11450	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O1A01_11455	COG2764	glyoxalase bleomycin resistance protein dioxygenase
O1A01_11470	COG1309	transcriptional regulator
O1A01_11475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O1A01_11480	COG1278	Cold shock
O1A01_11495	COG2188	Transcriptional regulator
O1A01_11500	COG1131	(ABC) transporter
O1A01_11505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1A01_11530	COG1363	Peptidase, m42
O1A01_11535	COG1533	DNA photolyase activity
O1A01_11550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
O1A01_11555	COG2224	Isocitrate lyase
O1A01_11570	COG2814	Major facilitator Superfamily
O1A01_11585	COG1388	LysM domain
O1A01_11585	COG3584	3D domain protein
O1A01_11625	COG0668	transmembrane transport
O1A01_11635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1A01_11650	COG3285	dna ligase
O1A01_11650	COG1793	dna ligase
O1A01_11655	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
O1A01_11670	COG1191	sigma factor activity
O1A01_11685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O1A01_11690	COG2814	Major facilitator Superfamily
O1A01_11715	COG5002	protein histidine kinase activity
O1A01_11720	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O1A01_11725	COG0640	Transcriptional regulator
O1A01_11730	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
O1A01_11735	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
O1A01_11740	COG1278	Cold shock
O1A01_11745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O1A01_11750	COG0436	Aminotransferase
O1A01_11755	COG1850	ribulose-bisphosphate carboxylase activity
O1A01_11760	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
O1A01_11765	COG0235	Class ii aldolase
O1A01_11770	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
O1A01_11780	COG2861	carbohydrate metabolic process
O1A01_11800	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
O1A01_11805	COG3639	organic phosphonate transmembrane transporter activity
O1A01_11810	COG3639	organic phosphonate transmembrane transporter activity
O1A01_11815	COG0737	Belongs to the 5'-nucleotidase family
O1A01_11820	COG1846	Transcriptional regulator
O1A01_11830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O1A01_11845	COG3949	Membrane
O1A01_11850	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O1A01_11870	COG0720	synthase
O1A01_11880	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O1A01_11890	COG4873	Protein conserved in bacteria
O1A01_11940	COG1725	Transcriptional regulator
O1A01_11945	COG1131	(ABC) transporter
O1A01_11960	COG1131	(ABC) transporter
O1A01_11965	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
O1A01_11970	COG1136	(ABC) transporter
O1A01_11975	COG0577	efflux transmembrane transporter activity
O1A01_11980	COG0726	polysaccharide deacetylase
O1A01_12000	COG0714	Associated with various cellular activities
O1A01_12035	COG3546	catalase activity
O1A01_12040	COG1388	LysM domain
O1A01_12040	COG0791	NLP P60 protein
O1A01_12075	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_12090	COG2986	histidine ammonia-lyase
O1A01_12095	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
O1A01_12105	COG0010	Belongs to the arginase family
O1A01_12110	COG3859	Proton-coupled thiamine transporter YuaJ
O1A01_12115	COG2084	Dehydrogenase
O1A01_12120	COG4191	Histidine kinase
O1A01_12125	COG0733	neurotransmitter:sodium symporter activity
O1A01_12135	COG0436	Aminotransferase
O1A01_12145	COG5582	Belongs to the UPF0302 family
O1A01_12155	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_12165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1A01_12170	COG3594	Acyltransferase
O1A01_12185	COG1278	Cold shock
O1A01_12190	COG4191	Histidine kinase
O1A01_12195	COG1388	LysM domain
O1A01_12195	COG3584	3D domain protein
O1A01_12205	COG1404	Belongs to the peptidase S8 family
O1A01_12210	COG3620	sequence-specific DNA binding
O1A01_12225	COG0596	Alpha beta hydrolase
O1A01_12230	COG3011	Protein conserved in bacteria
O1A01_12235	COG5522	Integral membrane protein (intg_mem_TP0381)
O1A01_12245	COG1349	DNA-binding transcription factor activity
O1A01_12250	COG1105	Belongs to the carbohydrate kinase PfkB family
O1A01_12255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1A01_12255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O1A01_12255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O1A01_12265	COG3663	DNA glycosylase
O1A01_12275	COG0346	lactoylglutathione lyase activity
O1A01_12295	COG0714	Associated with various cellular activities
O1A01_12325	COG1842	Phage shock protein A
O1A01_12340	COG2197	response regulator
O1A01_12350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O1A01_12365	COG2873	o-acetylhomoserine
O1A01_12370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O1A01_12375	COG0326	Molecular chaperone. Has ATPase activity
O1A01_12395	COG4152	abc transporter atp-binding protein
O1A01_12400	COG2309	aminopeptidase activity
O1A01_12425	COG1388	LysM domain
O1A01_12425	COG3858	chitin binding
O1A01_12440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O1A01_12455	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
O1A01_12465	COG0745	RESPONSE REGULATOR receiver
O1A01_12470	COG5002	protein histidine kinase activity
O1A01_12485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O1A01_12495	COG1686	Belongs to the peptidase S11 family
O1A01_12515	COG2190	(PTS) system
O1A01_12520	COG1263	PTS System
O1A01_12520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1A01_12525	COG0366	Alpha amylase catalytic
O1A01_12535	COG0784	Response regulator, receiver
O1A01_12535	COG0835	chemotaxis
O1A01_12550	COG1408	metallophosphoesterase
O1A01_12555	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_12565	COG2200	EAL domain
O1A01_12580	COG4703	Protein of unknown function (DUF1797)
O1A01_12585	COG5506	Protein of unknown function (DUF1694)
O1A01_12595	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
O1A01_12600	COG0517	IMP dehydrogenase activity
O1A01_12605	COG2814	Major facilitator Superfamily
O1A01_12620	COG0583	DNA-binding transcription factor activity
O1A01_12630	COG2171	N-acyltransferase activity
O1A01_12635	COG1473	amidohydrolase
O1A01_12645	COG0668	transmembrane transport
O1A01_12650	COG1132	(ABC) transporter
O1A01_12655	COG1132	(ABC) transporter
O1A01_12660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O1A01_12660	COG1199	ATP-dependent helicase activity
O1A01_12680	COG0436	Aminotransferase
O1A01_12685	COG0017	Asparaginyl-tRNA synthetase
O1A01_12690	COG3935	DnaD domain protein
O1A01_12695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
O1A01_12705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O1A01_12705	COG4499	WXG100 protein secretion system (Wss), protein YukC
O1A01_12710	COG3331	DNA recombination
O1A01_12765	COG0392	lysyltransferase activity
O1A01_12765	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
O1A01_12770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O1A01_12775	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
O1A01_12780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O1A01_12785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O1A01_12790	COG0505	Belongs to the CarA family
O1A01_12800	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O1A01_12805	COG0137	argininosuccinate synthase activity
O1A01_12810	COG0165	Argininosuccinate lyase
O1A01_12820	COG1737	Transcriptional regulator
O1A01_12825	COG2188	Transcriptional regulator
O1A01_12830	COG0363	glucosamine-6-phosphate deaminase activity
O1A01_12835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O1A01_12840	COG5609	conserved protein (DUF2294)
O1A01_12865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_12870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_12870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_12890	COG1205	dead DEAH box helicase
O1A01_12890	COG1111	helicase
O1A01_12895	COG3359	exonuclease
O1A01_12905	COG4474	Belongs to the UPF0398 family
O1A01_12920	COG0116	Belongs to the methyltransferase superfamily
O1A01_12935	COG1199	ATP-dependent helicase activity
O1A01_12940	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
O1A01_12945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O1A01_12950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O1A01_12975	COG3424	synthase
O1A01_12980	COG1755	Isoprenylcysteine carboxyl methyltransferase
O1A01_12985	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
O1A01_13015	COG5658	integral membrane protein
O1A01_13025	COG1309	transcriptional regulator
O1A01_13030	COG1131	(ABC) transporter
O1A01_13035	COG3559	Exporter of polyketide antibiotics
O1A01_13055	COG0165	Argininosuccinate lyase
O1A01_13070	COG0395	ABC-type sugar transport system, permease component
O1A01_13075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O1A01_13095	COG3069	C4-dicarboxylate transmembrane transporter activity
O1A01_13105	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_13110	COG3711	transcriptional antiterminator
O1A01_13115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1A01_13115	COG2190	(PTS) system
O1A01_13115	COG1263	PTS System
O1A01_13130	COG0346	lactoylglutathione lyase activity
O1A01_13135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O1A01_13145	COG2357	RelA SpoT domain protein
O1A01_13170	COG0328	RNA-DNA hybrid ribonuclease activity
O1A01_13175	COG0328	RNA-DNA hybrid ribonuclease activity
O1A01_13190	COG1278	Cold shock
O1A01_13210	COG4974	Belongs to the 'phage' integrase family
O1A01_13230	COG1937	Protein conserved in bacteria
O1A01_13235	COG2210	Belongs to the sulfur carrier protein TusA family
O1A01_13245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_13250	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_13250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_13260	COG2210	Belongs to the sulfur carrier protein TusA family
O1A01_13265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_13265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_13270	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_13290	COG0726	polysaccharide deacetylase
O1A01_13295	COG1966	Carbon starvation protein
O1A01_13305	COG0517	IMP dehydrogenase activity
O1A01_13315	COG0697	spore germination
O1A01_13335	COG0517	IMP dehydrogenase activity
O1A01_13340	COG0662	Cupin 2, conserved barrel domain protein
O1A01_13350	COG1064	alcohol dehydrogenase
O1A01_13385	COG2226	methyltransferase
O1A01_13405	COG0584	glycerophosphoryl diester phosphodiesterase
O1A01_13420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1A01_13455	COG1307	EDD domain protein, DegV family
O1A01_13465	COG1418	mRNA catabolic process
O1A01_13470	COG0488	(ABC) transporter
O1A01_13475	COG1413	lyase activity
O1A01_13485	COG2136	Putative SAM-dependent methyltransferase
O1A01_13485	COG2521	methyltransferase
O1A01_13505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O1A01_13510	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O1A01_13520	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O1A01_13530	COG1307	EDD domain protein, DegV family
O1A01_13545	COG1999	signal sequence binding
O1A01_13555	COG2755	lipolytic protein G-D-S-L family
O1A01_13600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O1A01_13600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O1A01_13610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O1A01_13615	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
O1A01_13620	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
O1A01_13625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1A01_13630	COG0456	acetyltransferase
O1A01_13635	COG3829	transcription factor binding
O1A01_13640	COG1509	lysine 2,3-aminomutase activity
O1A01_13650	COG4479	Belongs to the UPF0346 family
O1A01_13690	COG0813	purine-nucleoside phosphorylase activity
O1A01_13695	COG1876	peptidase activity
O1A01_13715	COG0400	carboxylic ester hydrolase activity
O1A01_13720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O1A01_13730	COG3396	Phenylacetate-CoA oxygenase
O1A01_13760	COG1024	Enoyl-CoA hydratase
O1A01_13765	COG1012	belongs to the aldehyde dehydrogenase family
O1A01_13770	COG1250	3-hydroxyacyl-CoA dehydrogenase
O1A01_13775	COG0183	Belongs to the thiolase family
O1A01_13780	COG3327	negative regulation of DNA-templated transcription, initiation
O1A01_13800	COG4120	Belongs to the binding-protein-dependent transport system permease family
O1A01_13805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O1A01_13820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O1A01_13840	COG3185	4-Hydroxyphenylpyruvate dioxygenase
O1A01_13845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O1A01_13850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O1A01_13855	COG0179	Fumarylacetoacetate (FAA) hydrolase
O1A01_13865	COG2340	Cysteine-rich secretory protein family
O1A01_13875	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
O1A01_13880	COG0534	Mate efflux family protein
O1A01_13885	COG0861	Integral membrane protein TerC family
O1A01_13890	COG0714	Associated with various cellular activities
O1A01_13895	COG4548	von Willebrand factor, type A
O1A01_13900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O1A01_13920	COG1012	belongs to the aldehyde dehydrogenase family
O1A01_13930	COG3853	Toxic anion resistance protein (TelA)
O1A01_13955	COG3773	Cell wall hydrolase
O1A01_13960	COG2226	methyltransferase
O1A01_13970	COG0488	(ABC) transporter
O1A01_13985	COG1823	symporter activity
O1A01_13995	COG1012	belongs to the aldehyde dehydrogenase family
O1A01_14005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O1A01_14010	COG0514	ATP-dependent DNA helicase (RecQ)
O1A01_14020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O1A01_14025	COG2404	hydrolase activity, acting on ester bonds
O1A01_14030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O1A01_14040	COG2223	nitrite transmembrane transporter activity
O1A01_14045	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
O1A01_14050	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
O1A01_14065	COG3344	reverse transcriptase
O1A01_14080	COG3546	catalase activity
O1A01_14090	COG2340	Cysteine-rich secretory protein family
O1A01_14105	COG4589	Belongs to the CDS family
O1A01_14115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O1A01_14125	COG0514	ATP-dependent DNA helicase (RecQ)
O1A01_14130	COG3610	response to peptide
O1A01_14135	COG2966	Psort location CytoplasmicMembrane, score
O1A01_14150	COG0768	penicillin binding
O1A01_14165	COG0542	response to heat
O1A01_14180	COG2323	membrane
O1A01_14195	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
O1A01_14200	COG1733	regulation of RNA biosynthetic process
O1A01_14205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O1A01_14205	COG3153	acetyltransferase
O1A01_14210	COG0456	acetyltransferase
O1A01_14220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1A01_14235	COG3621	Patatin-like phospholipase
O1A01_14250	COG0745	RESPONSE REGULATOR receiver
O1A01_14255	COG3850	Histidine kinase
O1A01_14255	COG5002	protein histidine kinase activity
O1A01_14265	COG3212	peptidase
O1A01_14270	COG1966	Carbon starvation protein
O1A01_14280	COG0003	Pfam Anion-transporting ATPase
O1A01_14285	COG3906	Belongs to the UPF0473 family
O1A01_14310	COG0697	spore germination
O1A01_14315	COG1054	Belongs to the UPF0176 family
O1A01_14320	COG0697	spore germination
O1A01_14325	COG0077	Prephenate dehydratase
O1A01_14335	COG1404	Belongs to the peptidase S8 family
O1A01_14345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O1A01_14350	COG3739	integral membrane protein
O1A01_14355	COG3655	Transcriptional regulator
O1A01_14370	COG1247	-acetyltransferase
O1A01_14400	COG0346	lactoylglutathione lyase activity
O1A01_14405	COG2162	N-hydroxyarylamine O-acetyltransferase activity
O1A01_14410	COG0572	uridine kinase
O1A01_14430	COG3340	Belongs to the peptidase S51 family
O1A01_14465	COG4473	ABC transporter
O1A01_14475	COG1271	oxidase subunit
O1A01_14480	COG1294	oxidase, subunit
O1A01_14485	COG4988	ABC transporter
O1A01_14490	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O1A01_14495	COG1764	response to oxidative stress
O1A01_14530	COG0456	acetyltransferase
O1A01_14530	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
O1A01_14555	COG0406	alpha-ribazole phosphatase activity
O1A01_14575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O1A01_14585	COG2385	sporulation resulting in formation of a cellular spore
O1A01_14605	COG2207	Transcriptional regulator
O1A01_14605	COG3708	Transcriptional regulator
O1A01_14620	COG1090	epimerase
O1A01_14625	COG0778	Nitroreductase
O1A01_14695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O1A01_14700	COG0671	phosphoesterase, PA-phosphatase related
O1A01_14705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O1A01_14710	COG0187	DNA topoisomerase II activity
O1A01_14715	COG1832	CoA-binding protein
O1A01_14720	COG3858	chitin binding
O1A01_14725	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
O1A01_14735	COG2843	Capsule synthesis protein
O1A01_14740	COG1051	belongs to the nudix hydrolase family
O1A01_14745	COG4841	protein insertion into membrane
O1A01_14755	COG0824	Thioesterase
O1A01_14775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1A01_14780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
O1A01_14810	COG1484	DNA-dependent DNA replication
O1A01_14820	COG4846	Membrane protein involved in cytochrome C biogenesis
O1A01_14825	COG2201	protein-glutamate methylesterase activity
O1A01_14830	COG0785	Cytochrome C biogenesis protein
O1A01_14840	COG1132	(ABC) transporter
O1A01_14845	COG1132	(ABC) transporter
O1A01_14850	COG3763	UPF0154 protein
O1A01_14865	COG4224	UPF0291 protein
O1A01_14870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O1A01_14885	COG0174	glutamine synthetase
O1A01_14890	COG0789	Transcriptional regulator
O1A01_14895	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
O1A01_14900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O1A01_14905	COG2860	membrane
O1A01_14910	COG0464	growth
O1A01_14925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O1A01_14930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
O1A01_14940	COG4550	Control of competence regulator ComK, YlbF/YmcA
O1A01_14945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O1A01_14950	COG1013	pyruvate-flavodoxin oxidoreductase activity
O1A01_14965	COG2359	stage V sporulation protein S
O1A01_14970	COG1692	metallophosphoesterase
O1A01_14975	COG1418	mRNA catabolic process
O1A01_14980	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O1A01_14985	COG1546	Belongs to the CinA family
O1A01_14985	COG1058	Belongs to the CinA family
O1A01_14990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
O1A01_14995	COG1426	Protein conserved in bacteria
O1A01_15010	COG0300	oxidoreductase activity
O1A01_15015	COG0612	Peptidase, M16
O1A01_15020	COG0612	Peptidase, M16
O1A01_15025	COG2188	Transcriptional regulator
O1A01_15030	COG4980	gas vesicle protein
O1A01_15030	COG1674	ftsk spoiiie
O1A01_15040	COG0740	serine-type endopeptidase activity
O1A01_15045	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O1A01_15050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O1A01_15055	COG0527	aspartate kinase activity
O1A01_15060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O1A01_15065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O1A01_15070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O1A01_15075	COG1873	PFAM PRC-barrel domain
O1A01_15080	COG0612	Peptidase, M16
O1A01_15085	COG0726	polysaccharide deacetylase
O1A01_15090	COG1185	polyribonucleotide nucleotidyltransferase activity
O1A01_15095	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
O1A01_15100	COG0196	riboflavin kinase activity
O1A01_15105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
O1A01_15110	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
O1A01_15115	COG1550	Protein conserved in bacteria
O1A01_15125	COG1358	cellular component organization or biogenesis
O1A01_15130	COG2740	Nucleic-acid-binding protein implicated in transcription termination
O1A01_15135	COG0195	Participates in both transcription termination and antitermination
O1A01_15140	COG0779	Required for maturation of 30S ribosomal subunits
O1A01_15145	COG2176	DNA-directed DNA polymerase activity
O1A01_15150	COG0750	zinc metalloprotease
O1A01_15155	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
O1A01_15160	COG4589	Belongs to the CDS family
O1A01_15165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O1A01_15185	COG0052	Belongs to the universal ribosomal protein uS2 family
O1A01_15200	COG1191	sigma factor activity
O1A01_15205	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
O1A01_15210	COG1776	CheC inhibitor of MCP methylation
O1A01_15215	COG0835	chemotaxis
O1A01_15220	COG0643	Histidine kinase
O1A01_15220	COG2198	Histidine kinase
O1A01_15225	COG2201	protein-glutamate methylesterase activity
O1A01_15230	COG0455	bacterial-type flagellum organization
O1A01_15235	COG1419	protein localization to endoplasmic reticulum
O1A01_15240	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O1A01_15245	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O1A01_15250	COG1684	flagellar biosynthetic protein fliR
O1A01_15255	COG1987	bacterial-type flagellum assembly
O1A01_15260	COG1338	Plays a role in the flagellum-specific transport system
O1A01_15265	COG3190	flagellar
O1A01_15270	COG2201	protein-glutamate methylesterase activity
O1A01_15275	COG1776	CheC inhibitor of MCP methylation
O1A01_15275	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O1A01_15280	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O1A01_15285	COG1580	Controls the rotational direction of flagella during chemotaxis
O1A01_15290	COG1582	Flagellar protein (FlbD)
O1A01_15295	COG4786	Flagellar basal body rod
O1A01_15300	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
O1A01_15305	COG3144	bacterial-type flagellum assembly
O1A01_15320	COG1157	protein secretion by the type III secretion system
O1A01_15325	COG1317	bacterial-type flagellum organization
O1A01_15330	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O1A01_15335	COG1766	The M ring may be actively involved in energy transduction
O1A01_15340	COG1677	Flagellar hook-basal body complex protein FliE
O1A01_15345	COG1558	bacterial-type flagellum-dependent cell motility
O1A01_15350	COG1815	bacterial-type flagellum-dependent cell motility
O1A01_15355	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
O1A01_15360	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
O1A01_15365	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
O1A01_15370	COG4974	Belongs to the 'phage' integrase family
O1A01_15375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O1A01_15380	COG0758	DNA mediated transformation
O1A01_15385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
O1A01_15390	COG0045	succinate-CoA ligase (ADP-forming) activity
O1A01_15395	COG2257	FlhB HrpN YscU SpaS Family
O1A01_15410	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
O1A01_15430	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O1A01_15435	COG1837	Belongs to the UPF0109 family
O1A01_15445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
O1A01_15450	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
O1A01_15455	COG0552	protein localization to endoplasmic reticulum
O1A01_15460	COG1196	nuclear chromosome segregation
O1A01_15465	COG0571	ribonuclease III activity
O1A01_15470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O1A01_15475	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_15480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
O1A01_15485	COG0416	fatty acid biosynthetic process
O1A01_15495	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O1A01_15500	COG1760	l-serine dehydratase
O1A01_15505	COG1760	l-serine dehydratase
O1A01_15510	COG1461	Dihydroxyacetone kinase
O1A01_15515	COG1302	Protein conserved in bacteria
O1A01_15520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O1A01_15530	COG1564	THIamine pyrophosphokinase
O1A01_15535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O1A01_15540	COG1162	GTPase activity
O1A01_15545	COG2815	serine threonine protein kinase
O1A01_15545	COG0515	serine threonine protein kinase
O1A01_15550	COG0631	protein serine/threonine phosphatase activity
O1A01_15555	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O1A01_15560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O1A01_15560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O1A01_15565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O1A01_15575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O1A01_15580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O1A01_15585	COG1758	RNA polymerase activity
O1A01_15590	COG0194	GDP metabolic process
O1A01_15595	COG2052	Domain of unknown function (DUF370)
O1A01_15600	COG1561	YicC-like family, N-terminal region
O1A01_15605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
O1A01_15610	COG1293	RNA-binding protein homologous to eukaryotic snRNP
O1A01_15615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
O1A01_15620	COG0284	orotidine-5'-phosphate decarboxylase activity
O1A01_15625	COG0167	dihydroorotate dehydrogenase activity
O1A01_15630	COG0543	2 iron, 2 sulfur cluster binding
O1A01_15635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O1A01_15640	COG0505	Belongs to the CarA family
O1A01_15645	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O1A01_15650	COG0540	Belongs to the ATCase OTCase family
O1A01_15655	COG2233	PERMEase
O1A01_15660	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
O1A01_15665	COG0564	pseudouridine synthase activity
O1A01_15675	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O1A01_15680	COG3599	regulation of cell shape
O1A01_15685	COG2302	S4 RNA-binding domain
O1A01_15690	COG0762	integral membrane protein
O1A01_15695	COG1799	cell septum assembly
O1A01_15700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
O1A01_15705	COG1496	oxidoreductase activity
O1A01_15710	COG1873	PFAM PRC-barrel domain
O1A01_15720	COG1191	sigma factor activity
O1A01_15725	COG1191	sigma factor activity
O1A01_15735	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
O1A01_15740	COG0849	cell division
O1A01_15745	COG3856	small basic protein
O1A01_15750	COG3879	Bacterial protein of unknown function (DUF881)
O1A01_15755	COG3879	Bacterial protein of unknown function (DUF881)
O1A01_15760	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O1A01_15765	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O1A01_15770	COG0772	Belongs to the SEDS family
O1A01_15780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O1A01_15790	COG0768	penicillin binding
O1A01_15795	COG0768	penicillin binding
O1A01_15800	COG4839	cell division protein FtsL
O1A01_15805	COG0275	rRNA processing
O1A01_15810	COG2001	Belongs to the MraZ family
O1A01_15815	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
O1A01_15825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O1A01_15830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O1A01_15835	COG0511	ligase activity, forming carbon-carbon bonds
O1A01_15840	COG0439	Biotin carboxylase
O1A01_15845	COG0454	-acetyltransferase
O1A01_15855	COG1024	Enoyl-CoA hydratase
O1A01_15860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
O1A01_15865	COG1399	metal-binding, possibly nucleic acid-binding protein
O1A01_15870	COG1323	Belongs to the UPF0348 family
O1A01_15875	COG3480	Lon protease (S16) C-terminal proteolytic domain
O1A01_15880	COG1752	Esterase of the alpha-beta hydrolase superfamily
O1A01_15885	COG3314	Sporulation integral membrane protein YlbJ
O1A01_15890	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
O1A01_15895	COG0742	ribosomal rna small subunit methyltransferase
O1A01_15920	COG3679	Belongs to the UPF0342 family
O1A01_15950	COG2340	Cysteine-rich secretory protein family
O1A01_15955	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
O1A01_15960	COG2340	Cysteine-rich secretory protein family
O1A01_15970	COG0628	permease
O1A01_15980	COG3336	cytochrome c oxidase
O1A01_16005	COG0109	protoheme IX farnesyltransferase activity
O1A01_16010	COG1612	heme a metabolic process
O1A01_16015	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
O1A01_16020	COG4838	Belongs to the UPF0358 family
O1A01_16025	COG2066	Belongs to the glutaminase family
O1A01_16030	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O1A01_16035	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
O1A01_16045	COG4896	Protein conserved in bacteria
O1A01_16060	COG1217	gtp-binding protein TYPA
O1A01_16070	COG0483	inositol monophosphate 1-phosphatase activity
O1A01_16080	COG4493	Belongs to the UPF0637 family
O1A01_16085	COG4476	Belongs to the UPF0223 family
O1A01_16095	COG1982	Orn Lys Arg decarboxylase major
O1A01_16105	COG1846	Transcriptional regulator
O1A01_16110	COG0386	Belongs to the glutathione peroxidase family
O1A01_16135	COG0508	dehydrogenase complex catalyzes the overall conversion of
O1A01_16140	COG0022	dehydrogenase e1 component
O1A01_16160	COG5503	Protein of unknown function (DUF1447)
O1A01_16165	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O1A01_16170	COG0569	domain protein
O1A01_16175	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
O1A01_16200	COG0438	transferase activity, transferring glycosyl groups
O1A01_16205	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O1A01_16210	COG1803	Methylglyoxal synthase
O1A01_16215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O1A01_16220	COG1694	Mazg nucleotide pyrophosphohydrolase
O1A01_16225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O1A01_16230	COG2738	Putative neutral zinc metallopeptidase
O1A01_16240	COG4347	Protein of unknown function (DUF1405)
O1A01_16250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O1A01_16265	COG5582	Belongs to the UPF0302 family
O1A01_16270	COG0457	Tetratricopeptide repeat
O1A01_16280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O1A01_16285	COG0287	Prephenate dehydrogenase
O1A01_16290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O1A01_16295	COG0159	tryptophan synthase activity
O1A01_16300	COG0133	tryptophan synthase activity
O1A01_16305	COG0135	phosphoribosylanthranilate isomerase activity
O1A01_16310	COG0134	indole-3-glycerol-phosphate synthase activity
O1A01_16315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O1A01_16320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O1A01_16325	COG4401	Chorismate mutase type I
O1A01_16330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O1A01_16335	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O1A01_16340	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O1A01_16345	COG0105	UTP biosynthetic process
O1A01_16350	COG0142	geranyltranstransferase activity
O1A01_16355	COG2226	methyltransferase
O1A01_16360	COG0142	geranyltranstransferase activity
O1A01_16370	COG0302	gtp cyclohydrolase
O1A01_16375	COG0776	regulation of translation
O1A01_16380	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
O1A01_16400	COG1160	GTP binding
O1A01_16425	COG1304	FMN binding
O1A01_16430	COG0539	negative regulation of cytoplasmic translation
O1A01_16435	COG0204	Acyl-transferase
O1A01_16455	COG2959	enzyme of heme biosynthesis
O1A01_16460	COG3409	Peptidoglycan-binding domain 1 protein
O1A01_16460	COG3773	Cell wall hydrolase
O1A01_16465	COG2339	peptidase activity
O1A01_16475	COG0492	ferredoxin-NADP+ reductase activity
O1A01_16480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O1A01_16485	COG4862	establishment of competence for transformation
O1A01_16490	COG1408	metallophosphoesterase
O1A01_16505	COG1388	LysM domain
O1A01_16510	COG1266	CAAX protease self-immunity
O1A01_16515	COG0514	ATP-dependent DNA helicase (RecQ)
O1A01_16520	COG4955	Helix-turn-helix domain
O1A01_16525	COG1141	Ferredoxin
O1A01_16530	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
O1A01_16545	COG1595	DNA-templated transcription, initiation
O1A01_16560	COG5002	protein histidine kinase activity
O1A01_16565	COG0745	RESPONSE REGULATOR receiver
O1A01_16570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O1A01_16575	COG1333	cytochrome c biogenesis protein
O1A01_16580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1A01_16585	COG1187	pseudouridine synthase activity
O1A01_16590	COG0700	Nucleoside recognition
O1A01_16595	COG2715	membrane protein required for spore maturation
O1A01_16600	COG1686	Belongs to the peptidase S11 family
O1A01_16625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
O1A01_16630	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
O1A01_16635	COG1547	Domain of unknown function (DUF309)
O1A01_16645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
O1A01_16650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1A01_16650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1A01_16655	COG0307	riboflavin synthase, alpha
O1A01_16660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O1A01_16660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O1A01_16665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O1A01_16680	COG0697	spore germination
O1A01_16695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O1A01_16720	COG2172	sigma factor antagonist activity
O1A01_16730	COG1686	Belongs to the peptidase S11 family
O1A01_16750	COG4974	Belongs to the 'phage' integrase family
O1A01_16760	COG0735	belongs to the Fur family
O1A01_16765	COG1300	Membrane
O1A01_16775	COG1379	DNA repair
O1A01_16780	COG0494	nUDIX hydrolase
O1A01_16790	COG0667	Aldo Keto reductase
O1A01_16800	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
O1A01_16805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
O1A01_16810	COG0183	Belongs to the thiolase family
O1A01_16815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O1A01_16820	COG1073	alpha beta
O1A01_16835	COG0494	nUDIX hydrolase
O1A01_16840	COG2223	nitrite transmembrane transporter activity
O1A01_16845	COG1882	Formate acetyltransferase
O1A01_16850	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
O1A01_16860	COG2076	Multidrug Resistance protein
O1A01_16865	COG2076	Multidrug Resistance protein
O1A01_16895	COG1595	DNA-templated transcription, initiation
O1A01_16925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O1A01_16950	COG0300	oxidoreductase activity
O1A01_16955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_16960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O1A01_16985	COG1131	(ABC) transporter
O1A01_17030	COG0572	uridine kinase
O1A01_17050	COG2824	Alkylphosphonate utilization operon protein PhnA
O1A01_17070	COG1247	-acetyltransferase
O1A01_17080	COG2247	cell wall binding repeat
O1A01_17080	COG2385	sporulation resulting in formation of a cellular spore
O1A01_17085	COG4187	Peptidase family M20/M25/M40
O1A01_17090	COG1902	pentaerythritol trinitrate reductase activity
O1A01_17100	COG0346	lactoylglutathione lyase activity
O1A01_17105	COG0681	Belongs to the peptidase S26 family
O1A01_17125	COG1131	(ABC) transporter
O1A01_17135	COG2197	response regulator
O1A01_17140	COG4585	Histidine kinase
O1A01_17145	COG1234	tRNA 3'-trailer cleavage
O1A01_17155	COG0546	phosphoglycolate phosphatase activity
O1A01_17170	COG1556	Lactate utilization protein
O1A01_17175	COG1139	Iron-sulfur cluster binding protein
O1A01_17180	COG0247	lactate metabolic process
O1A01_17185	COG0277	FAD linked oxidase domain protein
O1A01_17190	COG0247	lactate metabolic process
O1A01_17205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O1A01_17215	COG2195	Cleaves the N-terminal amino acid of tripeptides
O1A01_17220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O1A01_17225	COG0346	lactoylglutathione lyase activity
O1A01_17245	COG1376	ErfK ybiS ycfS ynhG family protein
O1A01_17250	COG4129	membrane
O1A01_17255	COG1164	Oligoendopeptidase f
O1A01_17265	COG1703	isobutyryl-CoA mutase activity
O1A01_17270	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1A01_17270	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1A01_17275	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1A01_17305	COG0508	dehydrogenase complex catalyzes the overall conversion of
O1A01_17310	COG0022	dehydrogenase e1 component
O1A01_17315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O1A01_17320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O1A01_17335	COG0280	phosphate acetyltransferase
O1A01_17340	COG3829	transcription factor binding
O1A01_17340	COG3290	protein histidine kinase activity
O1A01_17350	COG0584	glycerophosphoryl diester phosphodiesterase
O1A01_17355	COG3093	addiction module antidote protein HigA
O1A01_17360	COG0745	RESPONSE REGULATOR receiver
O1A01_17365	COG0750	zinc metalloprotease
O1A01_17370	COG0497	DNA recombination
O1A01_17375	COG1438	arginine binding
O1A01_17380	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
O1A01_17385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O1A01_17405	COG1570	exodeoxyribonuclease VII activity
O1A01_17410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O1A01_17415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O1A01_17420	COG1302	Protein conserved in bacteria
O1A01_17425	COG0439	Biotin carboxylase
O1A01_17430	COG0511	ligase activity, forming carbon-carbon bonds
O1A01_17470	COG3854	ATPases associated with a variety of cellular activities
O1A01_17480	COG1131	(ABC) transporter
O1A01_17490	COG0366	Alpha amylase catalytic
O1A01_17500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O1A01_17505	COG0006	proline dipeptidase activity
O1A01_17510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
O1A01_17525	COG1752	Esterase of the alpha-beta hydrolase superfamily
O1A01_17555	COG2318	DinB family
O1A01_17565	COG0697	spore germination
O1A01_17570	COG0531	amino acid
O1A01_17585	COG1309	transcriptional regulator
O1A01_17600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O1A01_17605	COG0095	Lipoate-protein ligase
O1A01_17610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_17625	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O1A01_17630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
O1A01_17635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O1A01_17655	COG3275	phosphorelay sensor kinase activity
O1A01_17665	COG1966	Carbon starvation protein
O1A01_17680	COG1012	belongs to the aldehyde dehydrogenase family
O1A01_17700	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_17715	COG1272	protein, Hemolysin III
O1A01_17735	COG0793	Belongs to the peptidase S41A family
O1A01_17740	COG0456	acetyltransferase
O1A01_17810	COG2318	DinB family
O1A01_17815	COG2333	competence protein COMEC
O1A01_17815	COG0658	competence protein
O1A01_17825	COG2124	cytochrome p450
O1A01_17830	COG1376	ErfK ybiS ycfS ynhG family protein
O1A01_17840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O1A01_17845	COG0697	spore germination
O1A01_17850	COG0592	DNA-directed DNA polymerase activity
O1A01_17865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O1A01_17870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1A01_17900	COG4970	Tfp pilus assembly protein FimT
O1A01_17905	COG4537	Required for transformation and DNA binding
O1A01_17910	COG1459	type II secretion system
O1A01_17915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O1A01_17920	COG4191	Histidine kinase
O1A01_17950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_17965	COG0011	TIGRFAM Protein of
O1A01_17980	COG1368	sulfuric ester hydrolase activity
O1A01_17985	COG1940	carbohydrate kinase activity
O1A01_17995	COG0697	spore germination
O1A01_18005	COG0457	Tetratricopeptide repeat
O1A01_18005	COG0705	Rhomboid family
O1A01_18025	COG0039	L-malate dehydrogenase activity
O1A01_18035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O1A01_18065	COG1172	Belongs to the binding-protein-dependent transport system permease family
O1A01_18070	COG1129	ABC transporter
O1A01_18085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O1A01_18090	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
O1A01_18095	COG0640	Transcriptional regulator
O1A01_18110	COG0659	secondary active sulfate transmembrane transporter activity
O1A01_18115	COG0704	Plays a role in the regulation of phosphate uptake
O1A01_18120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O1A01_18125	COG0581	inorganic phosphate transmembrane transporter activity
O1A01_18130	COG0573	inorganic phosphate transmembrane transporter activity
O1A01_18135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
O1A01_18140	COG0768	penicillin binding
O1A01_18145	COG0477	Major facilitator Superfamily
O1A01_18155	COG0205	6-phosphofructokinase activity
O1A01_18175	COG2839	Protein conserved in bacteria
O1A01_18185	COG5521	maltodextrose utilization protein MalA
O1A01_18195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
O1A01_18200	COG4709	membrane
O1A01_18205	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
O1A01_18220	COG0735	belongs to the Fur family
O1A01_18225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O1A01_18230	COG1121	(ABC) transporter
O1A01_18235	COG4191	Histidine kinase
O1A01_18245	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
O1A01_18260	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O1A01_18265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
O1A01_18270	COG2384	SAM-dependent methyltransferase
O1A01_18275	COG2010	Cytochrome c
O1A01_18280	COG1960	acyl-CoA dehydrogenase activity
O1A01_18290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O1A01_18295	COG0358	DNA primase activity
O1A01_18300	COG1671	Belongs to the UPF0178 family
O1A01_18305	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
O1A01_18310	COG0517	IMP dehydrogenase activity
O1A01_18315	COG0751	glycine-tRNA ligase activity
O1A01_18325	COG1381	Involved in DNA repair and RecF pathway recombination
O1A01_18335	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
O1A01_18340	COG0295	cytidine deaminase activity
O1A01_18345	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
O1A01_18355	COG1480	7TM receptor with intracellular HD hydrolase
O1A01_18360	COG1702	phosphate starvation-inducible protein PhoH
O1A01_18375	COG0494	nUDIX hydrolase
O1A01_18385	COG4864	UPF0365 protein
O1A01_18390	COG1030	water channel activity
O1A01_18395	COG1610	YqeY-like protein
O1A01_18410	COG1283	sodium-dependent phosphate transmembrane transporter activity
O1A01_18415	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
O1A01_18430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O1A01_18435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
O1A01_18440	COG2264	protein methyltransferase activity
O1A01_18445	COG0484	heat shock protein binding
O1A01_18450	COG0443	Heat shock 70 kDa protein
O1A01_18460	COG1420	regulation of RNA biosynthetic process
O1A01_18465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O1A01_18480	COG0860	N-Acetylmuramoyl-L-alanine amidase
O1A01_18495	COG1466	dna polymerase III delta subunit
O1A01_18505	COG0658	competence protein
O1A01_18505	COG2333	competence protein COMEC
O1A01_18510	COG2131	deaminase
O1A01_18515	COG1555	photosystem II stabilization
O1A01_18515	COG1596	polysaccharide export
O1A01_18520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O1A01_18525	COG2226	methyltransferase
O1A01_18530	COG0799	negative regulation of ribosome biogenesis
O1A01_18535	COG1713	HD superfamily hydrolase involved in NAD metabolism
O1A01_18540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
O1A01_18545	COG1534	Rna-binding protein
O1A01_18555	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
O1A01_18560	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
O1A01_18570	COG0688	phosphatidylethanolamine metabolic process
O1A01_18600	COG1525	nuclease
O1A01_18625	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
O1A01_18630	COG1595	DNA-templated transcription, initiation
O1A01_18640	COG0626	cystathionine gamma-synthase activity
O1A01_18645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O1A01_18650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O1A01_18655	COG2226	methyltransferase
O1A01_18670	COG0768	penicillin binding
O1A01_18675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O1A01_18680	COG0572	uridine kinase
O1A01_18685	COG0826	peptidase U32
O1A01_18690	COG0826	peptidase U32
O1A01_18695	COG4122	O-methyltransferase activity
O1A01_18700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O1A01_18705	COG3906	Belongs to the UPF0473 family
O1A01_18710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O1A01_18730	COG0628	permease
O1A01_18735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O1A01_18755	COG3881	PFAM PRC-barrel domain
O1A01_18760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O1A01_18765	COG0457	Tetratricopeptide repeat
O1A01_18770	COG0482	sulfurtransferase activity
O1A01_18775	COG1104	cysteine desulfurase activity
O1A01_18780	COG1959	2 iron, 2 sulfur cluster binding
O1A01_18785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
O1A01_18800	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
O1A01_18815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
O1A01_18820	COG0124	histidyl-tRNA synthetase
O1A01_18830	COG0860	N-Acetylmuramoyl-L-alanine amidase
O1A01_18830	COG3103	Sh3 type 3 domain protein
O1A01_18830	COG4991	sh3 domain protein
O1A01_18835	COG1490	D-aminoacyl-tRNA deacylase activity
O1A01_18840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O1A01_18845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O1A01_18850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
O1A01_18850	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
O1A01_18855	COG5416	Lipopolysaccharide assembly protein A domain
O1A01_18860	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
O1A01_18865	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O1A01_18865	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O1A01_18875	COG2244	polysaccharide biosynthetic process
O1A01_18880	COG2323	membrane
O1A01_18890	COG1862	Preprotein translocase
O1A01_18900	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
O1A01_18910	COG2255	four-way junction helicase activity
O1A01_18915	COG0632	four-way junction helicase activity
O1A01_18935	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O1A01_18955	COG0157	Belongs to the NadC ModD family
O1A01_18960	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
O1A01_18965	COG1104	cysteine desulfurase activity
O1A01_18970	COG1827	regulation of RNA biosynthetic process
O1A01_18975	COG0366	Alpha amylase catalytic
O1A01_18980	COG4492	Belongs to the UPF0735 family
O1A01_18990	COG3290	protein histidine kinase activity
O1A01_19000	COG2868	ribosomal protein
O1A01_19005	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O1A01_19010	COG1530	ribonuclease E activity
O1A01_19015	COG1994	Peptidase M50
O1A01_19020	COG0739	heme binding
O1A01_19025	COG2894	cell division
O1A01_19030	COG0850	regulation of cytokinetic process
O1A01_19035	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
O1A01_19040	COG1792	Involved in formation and maintenance of cell shape
O1A01_19045	COG1077	Cell shape determining protein MreB Mrl
O1A01_19050	COG2003	Belongs to the UPF0758 family
O1A01_19080	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
O1A01_19090	COG1459	type II secretion system
O1A01_19100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O1A01_19125	COG3706	GGDEF domain
O1A01_19130	COG0285	dihydrofolate synthase activity
O1A01_19135	COG0525	valine-tRNA ligase activity
O1A01_19145	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O1A01_19150	COG1388	LysM domain
O1A01_19150	COG1388	LysM domain
O1A01_19155	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O1A01_19160	COG0113	porphobilinogen synthase activity
O1A01_19165	COG1587	Uroporphyrinogen-III synthase
O1A01_19170	COG0181	hydroxymethylbilane synthase activity
O1A01_19175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O1A01_19195	COG0765	amino acid transport
O1A01_19205	COG0218	Necessary for normal cell division and for the maintenance of normal septation
O1A01_19210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
O1A01_19215	COG1067	ATP-dependent peptidase activity
O1A01_19215	COG0470	DNA polymerase III
O1A01_19220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
O1A01_19225	COG0544	peptidyl-prolyl cis-trans isomerase activity
O1A01_19230	COG1477	protein flavinylation
O1A01_19230	COG0457	Tetratricopeptide repeat
O1A01_19240	COG0622	Phosphoesterase
O1A01_19245	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O1A01_19255	COG5401	PFAM Sporulation and spore germination
O1A01_19265	COG1846	Transcriptional regulator
O1A01_19270	COG2197	response regulator
O1A01_19275	COG0824	Thioesterase
O1A01_19280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O1A01_19285	COG1053	succinate dehydrogenase
O1A01_19290	COG2009	succinate dehydrogenase
O1A01_19295	COG1719	4-vinyl reductase, 4VR
O1A01_19305	COG0322	excinuclease ABC activity
O1A01_19310	COG3118	belongs to the thioredoxin family
O1A01_19315	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
O1A01_19320	COG2086	electron transfer activity
O1A01_19325	COG1024	Enoyl-CoA hydratase
O1A01_19330	COG1309	transcriptional regulator
O1A01_19335	COG0318	PFAM AMP-dependent synthetase and ligase
O1A01_19340	COG3766	membrane
O1A01_19345	COG1193	negative regulation of DNA recombination
O1A01_19350	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O1A01_19350	COG1796	DNA polymerase
O1A01_19355	COG1286	toxin biosynthetic process
O1A01_19360	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
O1A01_19365	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O1A01_19380	COG0072	phenylalanine-tRNA ligase activity
O1A01_19380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O1A01_19385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O1A01_19405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O1A01_19415	COG1363	Peptidase, m42
O1A01_19440	COG0398	Pfam SNARE associated Golgi protein
O1A01_19445	COG3326	Membrane
O1A01_19450	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
O1A01_19455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
O1A01_19460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
O1A01_19465	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O1A01_19475	COG3611	Membrane attachment protein
O1A01_19480	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O1A01_19490	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
O1A01_19495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O1A01_19505	COG1971	Probably functions as a manganese efflux pump
O1A01_19510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O1A01_19515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O1A01_19515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O1A01_19520	COG0330	HflC and HflK could
O1A01_19525	COG0330	HflC and HflK could
O1A01_19530	COG5002	protein histidine kinase activity
O1A01_19535	COG0745	RESPONSE REGULATOR receiver
O1A01_19545	COG0039	L-malate dehydrogenase activity
O1A01_19550	COG0538	isocitrate dehydrogenase activity
O1A01_19555	COG0372	Belongs to the citrate synthase family
O1A01_19560	COG2707	UPF0756 membrane protein
O1A01_19565	COG0628	permease
O1A01_19570	COG3030	protein affecting phage T7 exclusion by the F plasmid
O1A01_19580	COG0205	6-phosphofructokinase activity
O1A01_19585	COG0825	malonyl-CoA metabolic process
O1A01_19595	COG1725	Transcriptional regulator
O1A01_19600	COG0281	malic enzyme
O1A01_19605	COG0587	DNA-directed DNA polymerase activity
O1A01_19620	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
O1A01_19630	COG4109	DRTGG domain
O1A01_19640	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O1A01_19645	COG0006	proline dipeptidase activity
O1A01_19650	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_19660	COG0589	response to stress
O1A01_19680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
O1A01_19685	COG0827	DNA restriction-modification system
O1A01_19690	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
O1A01_19695	COG3874	Sporulation protein YtfJ
O1A01_19705	COG1714	RDD family
O1A01_19710	COG0616	signal peptide processing
O1A01_19715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O1A01_19720	COG1574	metal-dependent hydrolase with the TIM-barrel fold
O1A01_19730	COG0301	tRNA thio-modification
O1A01_19735	COG1104	cysteine desulfurase activity
O1A01_19740	COG1114	Component of the transport system for branched-chain amino acids
O1A01_19745	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
O1A01_19750	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O1A01_19755	COG1309	transcriptional regulator
O1A01_19760	COG1956	GAF domain-containing protein
O1A01_19765	COG0626	cystathionine gamma-synthase activity
O1A01_19770	COG2199	diguanylate cyclase activity
O1A01_19770	COG2203	Gaf domain
O1A01_19780	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
O1A01_19785	COG2207	Transcriptional regulator
O1A01_19790	COG1263	PTS System
O1A01_19790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1A01_19790	COG2190	(PTS) system
O1A01_19810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O1A01_19815	COG0454	-acetyltransferase
O1A01_19820	COG0517	IMP dehydrogenase activity
O1A01_19825	COG0123	including yeast histone deacetylase and acetoin utilization protein
O1A01_19835	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O1A01_19845	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
O1A01_19845	COG1605	Chorismate mutase
O1A01_19850	COG4980	gas vesicle protein
O1A01_19865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O1A01_19875	COG1674	ftsk spoiiie
O1A01_19880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O1A01_19885	COG4848	Belongs to the UPF0354 family
O1A01_19890	COG1404	Belongs to the peptidase S8 family
O1A01_19890	COG4412	M6 family metalloprotease domain protein
O1A01_19895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1A01_19905	COG0840	transmembrane signaling receptor activity
O1A01_19925	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
O1A01_19930	COG1363	Peptidase, m42
O1A01_19935	COG5584	Small secreted protein
O1A01_19940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_19945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
O1A01_19955	COG0510	thiamine kinase activity
O1A01_19960	COG1523	belongs to the glycosyl hydrolase 13 family
O1A01_19970	COG1346	cytolysis
O1A01_19975	COG1380	Effector of murein hydrolase LrgA
O1A01_19985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O1A01_19995	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
O1A01_20000	COG1472	Belongs to the glycosyl hydrolase 3 family
O1A01_20005	COG3876	Protein conserved in bacteria
O1A01_20015	COG3842	ATPase activity
O1A01_20020	COG0395	ABC-type sugar transport system, permease component
O1A01_20025	COG1175	transmembrane transport
O1A01_20035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
O1A01_20050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1A01_20060	COG1131	(ABC) transporter
O1A01_20065	COG1349	DNA-binding transcription factor activity
O1A01_20070	COG1187	pseudouridine synthase activity
O1A01_20080	COG2244	polysaccharide biosynthetic process
O1A01_20090	COG2081	HI0933 family
O1A01_20105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_20110	COG0495	leucyl-tRNA aminoacylation
O1A01_20120	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_20125	COG2610	gluconate transmembrane transporter activity
O1A01_20140	COG2814	Major facilitator Superfamily
O1A01_20155	COG1242	4 iron, 4 sulfur cluster binding
O1A01_20160	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
O1A01_20170	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
O1A01_20180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O1A01_20185	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O1A01_20200	COG2267	carboxylic ester hydrolase activity
O1A01_20205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
O1A01_20215	COG0438	transferase activity, transferring glycosyl groups
O1A01_20225	COG0217	transcriptional regulatory protein
O1A01_20230	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O1A01_20240	COG1506	peptidase
O1A01_20245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O1A01_20250	COG1116	anion transmembrane transporter activity
O1A01_20255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O1A01_20260	COG0494	nUDIX hydrolase
O1A01_20275	COG0783	Belongs to the Dps family
O1A01_20290	COG0701	Predicted permease
O1A01_20295	COG1854	S-ribosylhomocysteine lyase activity
O1A01_20300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
O1A01_20305	COG0288	reversible hydration of carbon dioxide
O1A01_20320	COG1404	Belongs to the peptidase S8 family
O1A01_20325	COG0523	cobalamin synthesis protein
O1A01_20335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O1A01_20340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O1A01_20340	COG1321	iron dependent repressor
O1A01_20345	COG1121	(ABC) transporter
O1A01_20350	COG0803	Belongs to the bacterial solute-binding protein 9 family
O1A01_20355	COG0318	PFAM AMP-dependent synthetase and ligase
O1A01_20360	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
O1A01_20365	COG0596	Alpha beta hydrolase
O1A01_20370	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
O1A01_20375	COG1169	isochorismate synthase
O1A01_20380	COG1575	Belongs to the MenA family. Type 1 subfamily
O1A01_20385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O1A01_20395	COG0058	SHG alpha-glucan phosphorylase activity
O1A01_20400	COG0297	glycogen (starch) synthase activity
O1A01_20405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O1A01_20410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O1A01_20565	COG1285	pathogenesis
O1A01_20580	COG2223	nitrite transmembrane transporter activity
O1A01_20590	COG0243	molybdopterin cofactor binding
O1A01_20595	COG0437	4 iron, 4 sulfur cluster binding
O1A01_20600	COG0723	plastoquinol--plastocyanin reductase activity
O1A01_20615	COG0489	protein tyrosine kinase activity
O1A01_20625	COG1366	Belongs to the anti-sigma-factor antagonist family
O1A01_20640	COG1280	lysine exporter protein (LysE YggA)
O1A01_20655	COG1113	amino acid transport
O1A01_20660	COG1280	lysine exporter protein (LysE YggA)
O1A01_20670	COG3314	Sporulation integral membrane protein YlbJ
O1A01_20675	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O1A01_20680	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O1A01_20685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O1A01_20700	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
O1A01_20705	COG0673	inositol 2-dehydrogenase activity
O1A01_20720	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_20735	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O1A01_20755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O1A01_20755	COG2111	Na H antiporter
O1A01_20760	COG2111	Na H antiporter
O1A01_20765	COG1006	Multisubunit Na H antiporter MnhC subunit
O1A01_20770	COG0651	ATP synthesis coupled electron transport
O1A01_20775	COG1863	multisubunit Na H antiporter MnhE subunit
O1A01_20780	COG2212	antiporter activity
O1A01_20785	COG1320	monovalent cation:proton antiporter activity
O1A01_20790	COG1979	alcohol dehydrogenase
O1A01_20795	COG2155	Conserved Protein
O1A01_20800	COG1098	S1 RNA binding domain
O1A01_20810	COG2267	carboxylic ester hydrolase activity
O1A01_20820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
O1A01_20830	COG2032	superoxide dismutase activity
O1A01_20840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O1A01_20850	COG5018	Exonuclease
O1A01_20855	COG2814	Major facilitator Superfamily
O1A01_20865	COG2050	protein possibly involved in aromatic compounds catabolism
O1A01_20890	COG1595	DNA-templated transcription, initiation
O1A01_20900	COG4555	ABC transporter
O1A01_20905	COG0772	Belongs to the SEDS family
O1A01_20910	COG0772	Belongs to the SEDS family
O1A01_20920	COG1268	BioY protein
O1A01_20925	COG2056	Na+-H+ antiporter family
O1A01_20945	COG0697	spore germination
O1A01_20950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O1A01_20960	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
O1A01_20965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O1A01_20970	COG3584	3D domain protein
O1A01_20990	COG1252	NADH dehydrogenase
O1A01_21005	COG0316	Belongs to the HesB IscA family
O1A01_21010	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O1A01_21015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O1A01_21025	COG1252	NADH dehydrogenase
O1A01_21030	COG4837	Protein of unknown function (DUF1462)
O1A01_21040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O1A01_21045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O1A01_21050	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
O1A01_21055	COG0647	UMP catabolic process
O1A01_21060	COG2445	Protein of unknown function DUF86
O1A01_21075	COG4470	Protein conserved in bacteria
O1A01_21085	COG1011	Hydrolase
O1A01_21090	COG0527	aspartate kinase activity
O1A01_21100	COG0739	heme binding
O1A01_21110	COG0733	neurotransmitter:sodium symporter activity
O1A01_21115	COG1757	Na H antiporter
O1A01_21130	COG3377	Domain of unknown function (DUF1805)
O1A01_21135	COG0737	Belongs to the 5'-nucleotidase family
O1A01_21140	COG0730	response to heat
O1A01_21145	COG1801	Protein of unknown function DUF72
O1A01_21150	COG0719	Fe-S assembly protein
O1A01_21155	COG0822	iron-sulfur transferase activity
O1A01_21160	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O1A01_21165	COG0719	Fe-S assembly protein
O1A01_21170	COG0396	ATPase activity
O1A01_21180	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O1A01_21185	COG1464	Belongs to the NlpA lipoprotein family
O1A01_21195	COG2011	ABC-type metal ion transport system permease component
O1A01_21200	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O1A01_21210	COG2814	Major facilitator Superfamily
O1A01_21215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1A01_21220	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
O1A01_21235	COG0509	glycine decarboxylation via glycine cleavage system
O1A01_21240	COG1393	Belongs to the ArsC family
O1A01_21245	COG1960	acyl-CoA dehydrogenase activity
O1A01_21250	COG0183	Belongs to the thiolase family
O1A01_21255	COG1024	Enoyl-CoA hydratase
O1A01_21255	COG1250	3-hydroxyacyl-CoA dehydrogenase
O1A01_21280	COG5577	PFAM Coat F domain
O1A01_21295	COG1120	ATPase activity
O1A01_21300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O1A01_21305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O1A01_21310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O1A01_21315	COG0584	glycerophosphoryl diester phosphodiesterase
O1A01_21320	COG0737	Belongs to the 5'-nucleotidase family
O1A01_21330	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_21335	COG0750	zinc metalloprotease
O1A01_21355	COG1595	DNA-templated transcription, initiation
O1A01_21360	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_21360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_21365	COG1054	Belongs to the UPF0176 family
O1A01_21370	COG2210	Belongs to the sulfur carrier protein TusA family
O1A01_21375	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_21380	COG1937	Protein conserved in bacteria
O1A01_21385	COG0726	polysaccharide deacetylase
O1A01_21390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O1A01_21395	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O1A01_21405	COG1063	alcohol dehydrogenase
O1A01_21415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1A01_21415	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1A01_21440	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O1A01_21445	COG0557	exoribonuclease II activity
O1A01_21450	COG1647	Serine aminopeptidase, S33
O1A01_21460	COG1396	sequence-specific DNA binding
O1A01_21470	COG0681	Belongs to the peptidase S26 family
O1A01_21495	COG5002	protein histidine kinase activity
O1A01_21500	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O1A01_21510	COG0148	phosphopyruvate hydratase activity
O1A01_21520	COG0149	triose-phosphate isomerase activity
O1A01_21530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O1A01_21545	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
O1A01_21560	COG0740	serine-type endopeptidase activity
O1A01_21570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1A01_21575	COG1481	regulation of sporulation
O1A01_21580	COG0391	Required for morphogenesis under gluconeogenic growth conditions
O1A01_21585	COG1660	Displays ATPase and GTPase activities
O1A01_21590	COG1051	belongs to the nudix hydrolase family
O1A01_21595	COG0492	ferredoxin-NADP+ reductase activity
O1A01_21600	COG0457	Tetratricopeptide repeat
O1A01_21605	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O1A01_21605	COG0140	phosphoribosyl-ATP diphosphatase activity
O1A01_21610	COG0107	imidazoleglycerol-phosphate synthase activity
O1A01_21615	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O1A01_21625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O1A01_21630	COG0131	Imidazoleglycerol-phosphate dehydratase
O1A01_21635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O1A01_21645	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
O1A01_21650	COG0110	maltose O-acetyltransferase activity
O1A01_21655	COG0546	phosphoglycolate phosphatase activity
O1A01_21660	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
O1A01_21675	COG1950	PFAM Membrane protein of
O1A01_21680	COG1983	PspC domain protein
O1A01_21685	COG3595	metallopeptidase activity
O1A01_21700	COG0840	transmembrane signaling receptor activity
O1A01_21725	COG2508	Transcriptional regulator
O1A01_21730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O1A01_21735	COG0556	nucleotide-excision repair
O1A01_21750	COG1595	DNA-templated transcription, initiation
O1A01_21755	COG4897	Protein conserved in bacteria
O1A01_21765	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
O1A01_21785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O1A01_21790	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
O1A01_21795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O1A01_21800	COG3409	Peptidoglycan-binding domain 1 protein
O1A01_21800	COG0793	Belongs to the peptidase S41A family
O1A01_21805	COG0739	heme binding
O1A01_21810	COG2177	Part of the ABC transporter FtsEX involved in
O1A01_21815	COG2884	Cell division ATP-binding protein ftsE
O1A01_21830	COG1404	Belongs to the peptidase S8 family
O1A01_21840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O1A01_21855	COG0653	protein targeting
O1A01_21865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O1A01_21885	COG1516	flagellar protein fliS
O1A01_21890	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
O1A01_21905	COG4932	domain protein
O1A01_21905	COG5492	domain, Protein
O1A01_21910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O1A01_21915	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
O1A01_21920	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
O1A01_21930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O1A01_21935	COG1256	bacterial-type flagellum assembly
O1A01_21935	COG4786	Flagellar basal body rod
O1A01_21955	COG1040	competence protein
O1A01_21960	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
O1A01_21965	COG1307	EDD domain protein, DegV family
O1A01_21985	COG2197	response regulator
O1A01_21990	COG4585	Histidine kinase
O1A01_21995	COG1739	Uncharacterized protein family UPF0029
O1A01_22000	COG1316	TRANSCRIPTIONal
O1A01_22005	COG0438	transferase activity, transferring glycosyl groups
O1A01_22010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O1A01_22015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O1A01_22035	COG4464	protein tyrosine phosphatase activity
O1A01_22040	COG3764	Sortase (surface protein transpeptidase)
O1A01_22055	COG4715	Zinc finger, swim domain protein
O1A01_22060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O1A01_22075	COG0629	single-stranded DNA binding
O1A01_22085	COG3764	Sortase (surface protein transpeptidase)
O1A01_22105	COG1316	TRANSCRIPTIONal
O1A01_22110	COG1227	inorganic diphosphatase activity
O1A01_22115	COG1215	transferase activity, transferring glycosyl groups
O1A01_22130	COG4193	domain, Protein
O1A01_22135	COG0463	Glycosyl transferase, family 2
O1A01_22150	COG0860	N-Acetylmuramoyl-L-alanine amidase
O1A01_22150	COG2247	cell wall binding repeat
O1A01_22170	COG1215	transferase activity, transferring glycosyl groups
O1A01_22175	COG0438	transferase activity, transferring glycosyl groups
O1A01_22180	COG1653	transport
O1A01_22185	COG0395	ABC-type sugar transport system, permease component
O1A01_22190	COG1175	transmembrane transport
O1A01_22200	COG1316	TRANSCRIPTIONal
O1A01_22205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O1A01_22215	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
O1A01_22245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O1A01_22250	COG1464	Belongs to the NlpA lipoprotein family
O1A01_22255	COG0371	Dehydrogenase
O1A01_22260	COG2031	fatty acid transporter
O1A01_22265	COG2962	Rard protein
O1A01_22290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
O1A01_22320	COG2972	Histidine kinase
O1A01_22325	COG2182	Extracellular solute-binding protein
O1A01_22370	COG1404	Belongs to the peptidase S8 family
O1A01_22375	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
O1A01_22380	COG0673	inositol 2-dehydrogenase activity
O1A01_22390	COG0366	Alpha amylase catalytic
O1A01_22395	COG1653	transport
O1A01_22400	COG4753	response regulator
O1A01_22400	COG2207	Transcriptional regulator
O1A01_22415	COG0395	ABC-type sugar transport system, permease component
O1A01_22420	COG1175	transmembrane transport
O1A01_22425	COG1653	transport
O1A01_22585	COG1505	serine-type exopeptidase activity
O1A01_22645	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O1A01_22650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1A01_22655	COG1609	Transcriptional regulator
O1A01_22660	COG2706	6-phosphogluconolactonase activity
O1A01_22665	COG0346	lactoylglutathione lyase activity
O1A01_22675	COG3459	Glycosyltransferase 36 associated
O1A01_22685	COG3119	arylsulfatase activity
O1A01_22705	COG1132	(ABC) transporter
O1A01_22725	COG0395	ABC-type sugar transport system, permease component
O1A01_22730	COG1175	transmembrane transport
O1A01_22745	COG0395	ABC-type sugar transport system, permease component
O1A01_22765	COG1609	Transcriptional regulator
O1A01_22770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O1A01_22785	COG0363	glucosamine-6-phosphate deaminase activity
O1A01_22790	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O1A01_22795	COG3142	Participates in the control of copper homeostasis
O1A01_22805	COG2188	Transcriptional regulator
O1A01_22810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1A01_22810	COG1263	PTS System
O1A01_22815	COG2190	(PTS) system
O1A01_22825	COG0561	phosphatase activity
O1A01_22840	COG1063	alcohol dehydrogenase
O1A01_22845	COG1172	Belongs to the binding-protein-dependent transport system permease family
O1A01_22850	COG1129	ABC transporter
O1A01_22855	COG1879	ABC-type sugar transport system periplasmic component
O1A01_22865	COG1129	ABC transporter
O1A01_22870	COG1473	amidohydrolase
O1A01_22890	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
O1A01_22900	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_22905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O1A01_22965	COG1131	(ABC) transporter
O1A01_22985	COG1757	Na H antiporter
O1A01_23025	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
O1A01_23030	COG1072	(Pantothenic acid kinase))
O1A01_23040	COG2801	Transposase and inactivated derivatives
O1A01_23050	COG5583	Uncharacterized small protein (DUF2292)
O1A01_23055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O1A01_23065	COG3973	AAA domain
O1A01_23075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
O1A01_23100	COG0561	phosphatase activity
O1A01_23140	COG1737	Transcriptional regulator
O1A01_23190	COG0457	Tetratricopeptide repeat
O1A01_23190	COG0463	Glycosyl transferase, family 2
O1A01_23220	COG2814	Major facilitator Superfamily
O1A01_23255	COG5002	protein histidine kinase activity
O1A01_23260	COG0745	RESPONSE REGULATOR receiver
O1A01_23265	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
O1A01_23270	COG1131	(ABC) transporter
O1A01_23285	COG1929	Belongs to the glycerate kinase type-1 family
O1A01_23295	COG0383	alpha-mannosidase activity
O1A01_23300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1A01_23300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O1A01_23300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O1A01_23305	COG1737	Transcriptional regulator
O1A01_23310	COG1482	cell wall glycoprotein biosynthetic process
O1A01_23320	COG0024	Methionine aminopeptidase
O1A01_23340	COG0606	chelatase, subunit chli
O1A01_23375	COG3273	potassium ion transport
O1A01_23375	COG0471	metal ion transport
O1A01_23385	COG5001	Diguanylate cyclase
O1A01_23425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1A01_23430	COG0785	Cytochrome C biogenesis protein
O1A01_23440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_23460	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_23465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_23465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_23480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_23480	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_23500	COG1937	Protein conserved in bacteria
O1A01_23510	COG0730	response to heat
O1A01_23515	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_23520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_23520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_23530	COG2210	Belongs to the sulfur carrier protein TusA family
O1A01_23535	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_23535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_23540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_23620	COG2801	Transposase and inactivated derivatives
O1A01_23645	COG0463	Glycosyl transferase, family 2
O1A01_23645	COG1216	Glycosyl transferase, family 2
O1A01_23680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O1A01_23685	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O1A01_23690	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O1A01_23700	COG1086	Polysaccharide biosynthesis protein
O1A01_23710	COG0489	protein tyrosine kinase activity
O1A01_23715	COG3944	biosynthesis protein
O1A01_23765	COG4786	Flagellar basal body rod
O1A01_23780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1A01_23785	COG0765	amino acid transport
O1A01_23790	COG1126	abc transporter atp-binding protein
O1A01_23800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1A01_23820	COG2323	membrane
O1A01_23830	COG2197	response regulator
O1A01_23835	COG4585	Histidine kinase
O1A01_23840	COG3239	Fatty acid desaturase
O1A01_23845	COG1511	domain protein
O1A01_23850	COG1309	transcriptional regulator
O1A01_23855	COG0702	epimerase
O1A01_23860	COG1393	Belongs to the ArsC family
O1A01_23880	COG2226	methyltransferase
O1A01_23885	COG1476	TRANSCRIPTIONal
O1A01_23895	COG2723	6-phospho-beta-galactosidase activity
O1A01_23900	COG1077	Cell shape determining protein MreB Mrl
O1A01_23905	COG1609	Transcriptional regulator
O1A01_23920	COG0604	alcohol dehydrogenase
O1A01_23990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O1A01_23995	COG0395	ABC-type sugar transport system, permease component
O1A01_24020	COG0456	acetyltransferase
O1A01_24040	COG2153	protein acetylation
O1A01_24050	COG5002	protein histidine kinase activity
O1A01_24050	COG2176	DNA-directed DNA polymerase activity
O1A01_24065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1A01_24085	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
O1A01_24090	COG2059	Chromate
O1A01_24095	COG2059	Chromate
O1A01_24100	COG0405	Gamma-glutamyltransferase
O1A01_24105	COG3852	Histidine kinase
O1A01_24110	COG3852	Histidine kinase
O1A01_24115	COG0739	heme binding
O1A01_24135	COG2385	sporulation resulting in formation of a cellular spore
O1A01_24140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O1A01_24150	COG4836	Membrane
O1A01_24155	COG1007	ATP synthesis coupled electron transport
O1A01_24165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O1A01_24170	COG0713	ATP synthesis coupled electron transport
O1A01_24175	COG0839	Belongs to the complex I subunit 6 family
O1A01_24180	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1A01_24185	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
O1A01_24195	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1A01_24200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1A01_24210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O1A01_24215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O1A01_24220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O1A01_24225	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
O1A01_24230	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O1A01_24235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O1A01_24240	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O1A01_24245	COG0356	it plays a direct role in the translocation of protons across the membrane
O1A01_24260	COG1404	Belongs to the peptidase S8 family
O1A01_24275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
O1A01_24290	COG1595	DNA-templated transcription, initiation
O1A01_24300	COG0698	ribose 5-phosphate isomerase
O1A01_24305	COG5278	phosphoserine phosphatase activity
O1A01_24305	COG0840	transmembrane signaling receptor activity
O1A01_24310	COG0840	transmembrane signaling receptor activity
O1A01_24320	COG1971	Probably functions as a manganese efflux pump
O1A01_24325	COG0009	L-threonylcarbamoyladenylate synthase
O1A01_24340	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
O1A01_24375	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O1A01_24385	COG0697	spore germination
O1A01_24390	COG1435	thymidine kinase activity
O1A01_24400	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
O1A01_24405	COG1494	fructose-1,6-bisphosphatase
O1A01_24410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O1A01_24415	COG0191	fructose-bisphosphate aldolase activity
O1A01_24420	COG2204	response regulator
O1A01_24425	COG4821	SIS domain
O1A01_24430	COG0504	CTP synthase activity
O1A01_24435	COG3343	RNA polymerase activity
O1A01_24440	COG1703	isobutyryl-CoA mutase activity
O1A01_24440	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1A01_24440	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1A01_24445	COG3226	Transcriptional regulator
O1A01_24450	COG1960	acyl-CoA dehydrogenase activity
O1A01_24455	COG1960	acyl-CoA dehydrogenase activity
O1A01_24460	COG1250	3-hydroxyacyl-CoA dehydrogenase
O1A01_24470	COG0183	Belongs to the thiolase family
O1A01_24475	COG0247	lactate metabolic process
O1A01_24475	COG2181	nitrate reductase activity
O1A01_24480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O1A01_24495	COG1595	DNA-templated transcription, initiation
O1A01_24515	COG0675	Transposase, IS605 OrfB family
O1A01_24520	COG0010	Belongs to the arginase family
O1A01_24525	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
O1A01_24530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O1A01_24540	COG1994	Peptidase M50
O1A01_24550	COG0456	acetyltransferase
O1A01_24560	COG3465	dGTPase activity
O1A01_24565	COG1078	dGTPase activity
O1A01_24580	COG0095	Lipoate-protein ligase
O1A01_24585	COG0280	phosphate acetyltransferase
O1A01_24590	COG3253	May function as heme-dependent peroxidase
O1A01_24600	COG2363	Small membrane protein
O1A01_24605	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
O1A01_24615	COG1984	allophanate hydrolase subunit 2
O1A01_24630	COG2322	membrane
O1A01_24650	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O1A01_24655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
O1A01_24675	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
O1A01_24685	COG0501	Belongs to the peptidase M48B family
O1A01_24700	COG0778	Nitroreductase
O1A01_24710	COG2031	fatty acid transporter
O1A01_24715	COG0561	phosphatase activity
O1A01_24725	COG3314	Sporulation integral membrane protein YlbJ
O1A01_24750	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
O1A01_24755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O1A01_24755	COG0551	DNA topoisomerase type I activity
O1A01_24760	COG0488	(ABC) transporter
O1A01_24790	COG1595	DNA-templated transcription, initiation
O1A01_24810	COG3842	ATPase activity
O1A01_24820	COG1840	ABC-type Fe3 transport system, periplasmic component
O1A01_24825	COG1794	racemase activity, acting on amino acids and derivatives
O1A01_24835	COG0367	asparagine synthase
O1A01_24840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O1A01_24845	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O1A01_24850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O1A01_24865	COG4187	Peptidase family M20/M25/M40
O1A01_24870	COG1079	Belongs to the binding-protein-dependent transport system permease family
O1A01_24875	COG4603	Belongs to the binding-protein-dependent transport system permease family
O1A01_24880	COG3845	ABC transporter
O1A01_24885	COG1744	ABC transporter substrate-binding protein PnrA-like
O1A01_24890	COG1959	2 iron, 2 sulfur cluster binding
O1A01_24900	COG2814	Major facilitator Superfamily
O1A01_24915	COG1187	pseudouridine synthase activity
O1A01_24920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O1A01_24935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1A01_24960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O1A01_24965	COG0561	phosphatase activity
O1A01_24970	COG0798	PFAM Bile acid sodium symporter
O1A01_25000	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O1A01_25020	COG4191	Histidine kinase
O1A01_25025	COG1966	Carbon starvation protein
O1A01_25055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O1A01_25060	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
O1A01_25070	COG4863	YycH protein
O1A01_25075	COG5002	protein histidine kinase activity
O1A01_25080	COG0745	RESPONSE REGULATOR receiver
O1A01_25085	COG0739	heme binding
O1A01_25085	COG0741	lytic transglycosylase activity
O1A01_25085	COG1196	nuclear chromosome segregation
O1A01_25115	COG0305	Participates in initiation and elongation during chromosome replication
O1A01_25120	COG0359	binds to the 23S rRNA
O1A01_25125	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
O1A01_25135	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
O1A01_25155	COG4974	Belongs to the 'phage' integrase family
O1A01_25165	COG1404	Belongs to the peptidase S8 family
O1A01_25185	COG1396	sequence-specific DNA binding
O1A01_25195	COG1401	restriction endodeoxyribonuclease activity
O1A01_25220	COG0653	protein targeting
O1A01_25235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
O1A01_25245	COG0360	Binds together with S18 to 16S ribosomal RNA
O1A01_25250	COG0012	GTP binding
O1A01_25255	COG4481	Protein conserved in bacteria
O1A01_25260	COG3949	Membrane
O1A01_25275	COG1475	DNA binding
O1A01_25280	COG1192	Involved in chromosome partitioning
O1A01_25285	COG1475	DNA binding
O1A01_25290	COG0357	Ribosomal RNA small subunit methyltransferase G
O1A01_25295	COG0445	tRNA wobble uridine modification
O1A01_25300	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
O1A01_25305	COG1847	R3H domain protein
O1A01_25320	COG0230	Belongs to the bacterial ribosomal protein bL34 family