locus-tag	class	description
FG381_00020	COG0114	fumarate hydratase activity
FG381_00030	COG0656	L-ascorbic acid biosynthetic process
FG381_00045	COG3976	FMN-binding domain protein
FG381_00045	COG0431	NADPH-dependent FMN reductase
FG381_00045	COG1053	succinate dehydrogenase
FG381_00055	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FG381_00060	COG4977	sequence-specific DNA binding
FG381_00065	COG0656	L-ascorbic acid biosynthetic process
FG381_00085	COG0710	3-dehydroquinate dehydratase activity
FG381_00090	COG1053	succinate dehydrogenase
FG381_00100	COG1053	succinate dehydrogenase
FG381_00105	COG0745	RESPONSE REGULATOR receiver
FG381_00110	COG5002	protein histidine kinase activity
FG381_00110	COG5000	phosphorelay sensor kinase activity
FG381_00120	COG3177	Filamentation induced by cAMP protein fic
FG381_00140	COG1960	acyl-CoA dehydrogenase activity
FG381_00145	COG4670	ketone body catabolic process
FG381_00160	COG2271	Major facilitator Superfamily
FG381_00165	COG2086	electron transfer activity
FG381_00170	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FG381_00175	COG0644	oxidoreductase
FG381_00180	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
FG381_00185	COG0318	PFAM AMP-dependent synthetase and ligase
FG381_00190	COG0738	Major facilitator superfamily
FG381_00195	COG2207	Transcriptional regulator
FG381_00195	COG1917	Cupin 2, conserved barrel domain protein
FG381_00200	COG4279	zinc finger
FG381_00205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FG381_00210	COG1592	Rubrerythrin
FG381_00215	COG1846	Transcriptional regulator
FG381_00220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FG381_00225	COG2226	methyltransferase
FG381_00230	COG1120	ATPase activity
FG381_00235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FG381_00240	COG0512	Glutamine amidotransferase of anthranilate synthase
FG381_00280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FG381_00285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FG381_00290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FG381_00295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FG381_00300	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FG381_00305	COG1858	cytochrome C peroxidase
FG381_00345	COG2801	Transposase and inactivated derivatives
FG381_00350	COG4372	Transposase
FG381_00435	COG0655	NAD(P)H dehydrogenase (quinone) activity
FG381_00450	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FG381_00450	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FG381_00460	COG0747	negative chemotaxis
FG381_00475	COG1053	succinate dehydrogenase
FG381_00495	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FG381_00515	COG2249	NAD(P)H dehydrogenase (quinone) activity
FG381_00525	COG2119	membrane
FG381_00540	COG0583	DNA-binding transcription factor activity
FG381_00555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FG381_00555	COG0140	phosphoribosyl-ATP diphosphatase activity
FG381_00575	COG0131	Imidazoleglycerol-phosphate dehydratase
FG381_00575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FG381_00580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FG381_00595	COG0697	spore germination
FG381_00635	COG3976	FMN-binding domain protein
FG381_00635	COG1053	succinate dehydrogenase
FG381_00645	COG0083	homoserine kinase activity
FG381_00660	COG0527	aspartate kinase activity
FG381_00665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FG381_00685	COG3264	Mechanosensitive ion channel
FG381_00685	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FG381_00700	COG2801	Transposase and inactivated derivatives
FG381_00705	COG1114	Component of the transport system for branched-chain amino acids
FG381_00720	COG1556	Lactate utilization protein
FG381_00725	COG1139	Iron-sulfur cluster binding protein
FG381_00730	COG0247	lactate metabolic process
FG381_00735	COG1620	l-lactate permease
FG381_00750	COG2171	N-acyltransferase activity
FG381_00755	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FG381_00760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FG381_00765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FG381_00775	COG1473	amidohydrolase
FG381_00780	COG0583	DNA-binding transcription factor activity
FG381_00850	COG2801	Transposase and inactivated derivatives
FG381_00980	COG3039	Transposase
FG381_00995	COG0066	3-isopropylmalate dehydratase activity
FG381_01000	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FG381_01025	COG3585	molybdate ion transport
FG381_01030	COG3976	FMN-binding domain protein
FG381_01030	COG1053	succinate dehydrogenase
FG381_01030	COG0431	NADPH-dependent FMN reductase
FG381_01040	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FG381_01045	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FG381_01060	COG0642	Histidine kinase
FG381_01065	COG0745	RESPONSE REGULATOR receiver
FG381_01070	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FG381_01105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FG381_01115	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FG381_01135	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FG381_01145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FG381_01150	COG0601	transmembrane transport
FG381_01175	COG4166	transmembrane transport
FG381_01180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FG381_01190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FG381_01245	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FG381_01270	COG0436	Aminotransferase
FG381_01275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FG381_01280	COG1131	(ABC) transporter
FG381_01285	COG0842	Transport permease protein
FG381_01290	COG0842	Transport permease protein
FG381_01300	COG0667	Aldo Keto reductase
FG381_01310	COG0667	Aldo Keto reductase
FG381_01330	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FG381_01350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FG381_01355	COG0243	molybdopterin cofactor binding
FG381_01370	COG0243	molybdopterin cofactor binding
FG381_01375	COG0437	4 iron, 4 sulfur cluster binding
FG381_01390	COG0326	Molecular chaperone. Has ATPase activity
FG381_01400	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FG381_01410	COG2116	formate transmembrane transporter activity
FG381_01435	COG0765	amino acid transport
FG381_01440	COG1126	abc transporter atp-binding protein
FG381_01445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FG381_01465	COG1053	succinate dehydrogenase
FG381_01475	COG1053	succinate dehydrogenase
FG381_01480	COG4566	intracellular signal transduction
FG381_01510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FG381_01515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FG381_01525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FG381_01550	COG2801	Transposase and inactivated derivatives
FG381_01575	COG2207	Transcriptional regulator
FG381_01585	COG2195	Cleaves the N-terminal amino acid of tripeptides
FG381_01590	COG3069	C4-dicarboxylate transmembrane transporter activity
FG381_01600	COG3681	Belongs to the UPF0597 family
FG381_01605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FG381_01680	COG2336	PFAM SpoVT AbrB
FG381_01685	COG2337	Toxic component of a toxin-antitoxin (TA) module
FG381_01715	COG1979	alcohol dehydrogenase
FG381_01720	COG1929	Belongs to the glycerate kinase type-1 family
FG381_01725	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FG381_01745	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FG381_01790	COG1215	transferase activity, transferring glycosyl groups
FG381_01795	COG1215	transferase activity, transferring glycosyl groups
FG381_01800	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FG381_01805	COG0457	Tetratricopeptide repeat
FG381_01805	COG3118	belongs to the thioredoxin family
FG381_01810	COG3300	MHYT domain
FG381_01810	COG5001	Diguanylate cyclase
FG381_01815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FG381_01820	COG3706	GGDEF domain
FG381_01835	COG2194	sulfuric ester hydrolase activity
FG381_01860	COG0765	amino acid transport
FG381_01870	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FG381_01880	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FG381_01885	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FG381_01890	COG4208	sulfate ABC transporter
FG381_01895	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FG381_01905	COG0583	DNA-binding transcription factor activity
FG381_01910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FG381_01945	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FG381_01950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FG381_01985	COG0251	oxidation-reduction process
FG381_01990	COG2964	Protein conserved in bacteria
FG381_02005	COG3069	C4-dicarboxylate transmembrane transporter activity
FG381_02010	COG2194	sulfuric ester hydrolase activity
FG381_02025	COG1773	rubredoxin
FG381_02040	COG0298	carbon dioxide binding
FG381_02070	COG0347	Belongs to the P(II) protein family
FG381_02075	COG0004	ammonium transporteR
FG381_02085	COG3015	lipoprotein NlpE involved in copper resistance
FG381_02090	COG0252	asparaginase activity
FG381_02110	COG0437	4 iron, 4 sulfur cluster binding
FG381_02120	COG1227	inorganic diphosphatase activity
FG381_02125	COG3069	C4-dicarboxylate transmembrane transporter activity
FG381_02130	COG1970	mechanosensitive ion channel activity
FG381_02140	COG3366	ferrous iron transmembrane transporter activity
FG381_02145	COG0697	spore germination
FG381_02150	COG2910	NAD(P)H-binding
FG381_02175	COG1131	(ABC) transporter
FG381_02180	COG0842	Transport permease protein
FG381_02185	COG0842	Transport permease protein
FG381_02190	COG3383	formate dehydrogenase (NAD+) activity
FG381_02205	COG0583	DNA-binding transcription factor activity
FG381_02215	COG3069	C4-dicarboxylate transmembrane transporter activity
FG381_02235	COG3069	C4-dicarboxylate transmembrane transporter activity
FG381_02240	COG0165	Argininosuccinate lyase
FG381_02270	COG1473	amidohydrolase
FG381_02275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FG381_02280	COG2885	chlorophyll binding
FG381_02280	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FG381_02285	COG3468	outer membrane autotransporter barrel domain protein
FG381_02305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FG381_02310	COG2194	sulfuric ester hydrolase activity
FG381_02320	COG1215	transferase activity, transferring glycosyl groups
FG381_02325	COG1215	transferase activity, transferring glycosyl groups
FG381_02330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FG381_02345	COG1053	succinate dehydrogenase
FG381_02350	COG4191	Histidine kinase
FG381_02365	COG2801	Transposase and inactivated derivatives
FG381_02375	COG1053	succinate dehydrogenase
FG381_02375	COG3976	FMN-binding domain protein
FG381_02380	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FG381_02380	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FG381_02385	COG1053	succinate dehydrogenase
FG381_02390	COG1053	succinate dehydrogenase
FG381_02400	COG0243	molybdopterin cofactor binding
FG381_02405	COG1464	Belongs to the NlpA lipoprotein family
FG381_02425	COG2067	long-chain fatty acid transport protein
FG381_02430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FG381_02440	COG2040	homocysteine
FG381_02445	COG1464	Belongs to the NlpA lipoprotein family
FG381_02470	COG3976	FMN-binding domain protein
FG381_02470	COG1053	succinate dehydrogenase
FG381_02480	COG1690	Belongs to the RtcB family
FG381_02485	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FG381_02490	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FG381_02500	COG0428	transporter
FG381_02505	COG0589	response to stress
FG381_02510	COG0589	response to stress
FG381_02540	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FG381_02550	COG3976	FMN-binding domain protein
FG381_02550	COG1053	succinate dehydrogenase
FG381_02560	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FG381_02570	COG0583	DNA-binding transcription factor activity
FG381_02575	COG0700	Nucleoside recognition
FG381_02580	COG3366	ferrous iron transmembrane transporter activity
FG381_02590	COG0700	Nucleoside recognition
FG381_02595	COG3366	ferrous iron transmembrane transporter activity
FG381_02615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FG381_02650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FG381_02655	COG1473	amidohydrolase
FG381_02665	COG2356	endonuclease I
FG381_02685	COG1028	Short-chain dehydrogenase reductase Sdr
FG381_02690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FG381_02715	COG1053	succinate dehydrogenase
FG381_02715	COG0431	NADPH-dependent FMN reductase
FG381_02715	COG3976	FMN-binding domain protein
FG381_02725	COG4566	intracellular signal transduction
FG381_02735	COG1528	Iron-storage protein
FG381_02755	COG0583	DNA-binding transcription factor activity
FG381_02765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FG381_02770	COG0165	Argininosuccinate lyase
FG381_02770	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FG381_02780	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FG381_02800	COG4372	Transposase
FG381_02805	COG2801	Transposase and inactivated derivatives
FG381_02810	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FG381_02825	COG2217	Heavy metal translocating P-type atpase
FG381_02845	COG1918	ferrous iron import across plasma membrane
FG381_02865	COG0776	regulation of translation
FG381_02870	COG0534	Mate efflux family protein
FG381_02875	COG0564	pseudouridine synthase activity
FG381_02885	COG3976	FMN-binding domain protein
FG381_02885	COG1053	succinate dehydrogenase
FG381_02890	COG2217	Heavy metal translocating P-type atpase
FG381_02925	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FG381_02925	COG2885	chlorophyll binding
FG381_02930	COG3468	outer membrane autotransporter barrel domain protein
FG381_02950	COG0252	asparaginase activity
FG381_02970	COG0252	asparaginase activity
FG381_02980	COG3976	FMN-binding domain protein
FG381_02980	COG1053	succinate dehydrogenase
FG381_02980	COG0431	NADPH-dependent FMN reductase
FG381_02990	COG4566	intracellular signal transduction
FG381_02995	COG1122	ATPase activity
FG381_03000	COG4120	Belongs to the binding-protein-dependent transport system permease family
FG381_03010	COG4221	oxidoreductase activity
FG381_03015	COG3069	C4-dicarboxylate transmembrane transporter activity
FG381_03020	COG2223	nitrite transmembrane transporter activity
FG381_03025	COG1473	amidohydrolase
FG381_03045	COG1566	PFAM secretion protein HlyD family protein
FG381_03055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FG381_03070	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FG381_03085	COG0601	transmembrane transport
FG381_03110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FG381_03115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FG381_03130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FG381_03175	COG2801	Transposase and inactivated derivatives
FG381_03185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FG381_03185	COG4651	solute:proton antiporter activity
FG381_03190	COG2860	membrane
FG381_03195	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FG381_03200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FG381_03210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FG381_03220	COG3069	C4-dicarboxylate transmembrane transporter activity
FG381_03225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FG381_03235	COG0165	Argininosuccinate lyase
FG381_03250	COG0437	4 iron, 4 sulfur cluster binding
FG381_03260	COG4566	intracellular signal transduction
FG381_03265	COG2205	protein histidine kinase activity
FG381_03270	COG3477	response to acidic pH
FG381_03295	COG3069	C4-dicarboxylate transmembrane transporter activity
FG381_03320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FG381_03325	COG1121	(ABC) transporter
FG381_03330	COG0803	Belongs to the bacterial solute-binding protein 9 family
FG381_03340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FG381_03345	COG0765	amino acid transport
FG381_03360	COG0825	malonyl-CoA metabolic process
FG381_03365	COG0215	cysteine-tRNA ligase activity
FG381_03385	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FG381_03390	COG2329	Antibiotic biosynthesis monooxygenase
FG381_03425	COG4172	Belongs to the ABC transporter superfamily
FG381_03430	COG0747	negative chemotaxis
FG381_03435	COG0601	transmembrane transport
FG381_03440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FG381_03475	COG0385	Bile acid
FG381_03485	COG3976	FMN-binding domain protein
FG381_03485	COG1053	succinate dehydrogenase
FG381_03495	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FG381_03520	COG1957	nucleoside hydrolase
FG381_03555	COG1120	ATPase activity
FG381_03560	COG4774	siderophore transport
FG381_03570	COG0385	Bile acid
FG381_03595	COG2207	Transcriptional regulator
FG381_03600	COG1691	(AIR) carboxylase
FG381_03605	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
FG381_03615	COG0549	Belongs to the carbamate kinase family
FG381_03625	COG3257	ureidoglycine aminohydrolase activity
FG381_03640	COG1288	antiporter activity
FG381_03650	COG1136	(ABC) transporter
FG381_03665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FG381_03670	COG0484	heat shock protein binding
FG381_03690	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FG381_03715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FG381_03725	COG4372	Transposase
FG381_03745	COG2801	Transposase and inactivated derivatives
FG381_03765	COG1733	regulation of RNA biosynthetic process
FG381_03785	COG1757	Na H antiporter
FG381_03795	COG0667	Aldo Keto reductase
FG381_03820	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FG381_03840	COG4133	protoheme IX ABC transporter activity
FG381_03850	COG0322	excinuclease ABC activity
FG381_03855	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FG381_03870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FG381_03880	COG1473	amidohydrolase
FG381_03895	COG0402	S-adenosylhomocysteine deaminase activity
FG381_03900	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FG381_03905	COG2197	response regulator
FG381_03910	COG2205	protein histidine kinase activity
FG381_03915	COG1619	proteins homologs of microcin C7 resistance protein MccF
FG381_03920	COG0590	tRNA wobble adenosine to inosine editing
FG381_03940	COG1979	alcohol dehydrogenase
FG381_03945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FG381_03950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FG381_03955	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FG381_03965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FG381_03970	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FG381_03995	COG3976	FMN-binding domain protein
FG381_03995	COG1053	succinate dehydrogenase
FG381_04035	COG4566	intracellular signal transduction
FG381_04045	COG1053	succinate dehydrogenase
FG381_04045	COG3976	FMN-binding domain protein
FG381_04055	COG0745	RESPONSE REGULATOR receiver
FG381_04060	COG2205	protein histidine kinase activity
FG381_04065	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FG381_04095	COG3039	Transposase
FG381_04120	COG1053	succinate dehydrogenase
FG381_04130	COG4251	negative regulation of phosphorylation
FG381_04135	COG0242	peptide deformylase activity
FG381_04145	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FG381_04160	COG2890	protein-(glutamine-N5) methyltransferase activity
FG381_04165	COG0488	(ABC) transporter
FG381_04180	COG0728	peptidoglycan biosynthetic process
FG381_04185	COG0268	Binds directly to 16S ribosomal RNA
FG381_04190	COG1272	protein, Hemolysin III
FG381_04195	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FG381_04200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FG381_04205	COG0142	geranyltranstransferase activity
FG381_04230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FG381_04230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FG381_04255	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FG381_04265	COG2878	Part of a membrane complex involved in electron transport
FG381_04270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FG381_04280	COG3850	Histidine kinase
FG381_04305	COG3976	FMN-binding domain protein
FG381_04305	COG1053	succinate dehydrogenase
FG381_04305	COG0431	NADPH-dependent FMN reductase
FG381_04315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FG381_04360	COG0544	peptidyl-prolyl cis-trans isomerase activity
FG381_04390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FG381_04395	COG0477	Major facilitator Superfamily
FG381_04405	COG0419	ATPase involved in DNA repair
FG381_04410	COG0420	3'-5' exonuclease activity
FG381_04415	COG1053	succinate dehydrogenase
FG381_04420	COG0243	molybdopterin cofactor binding
FG381_04420	COG3383	formate dehydrogenase (NAD+) activity
FG381_04425	COG0437	4 iron, 4 sulfur cluster binding
FG381_04450	COG1823	symporter activity
FG381_04460	COG1053	succinate dehydrogenase
FG381_04470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FG381_04480	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FG381_04485	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FG381_04505	COG1530	ribonuclease E activity
FG381_04525	COG1053	succinate dehydrogenase
FG381_04525	COG3976	FMN-binding domain protein
FG381_04530	COG4566	intracellular signal transduction
FG381_04535	COG4191	Histidine kinase
FG381_04555	COG0738	Major facilitator superfamily
FG381_04580	COG1012	belongs to the aldehyde dehydrogenase family
FG381_04585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FG381_04600	COG2814	Major facilitator Superfamily
FG381_04605	COG2814	Major facilitator Superfamily
FG381_04615	COG0251	oxidation-reduction process
FG381_04640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FG381_04650	COG3710	Transcriptional regulator
FG381_04665	COG0534	Mate efflux family protein
FG381_04670	COG0531	amino acid
FG381_04675	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FG381_04680	COG1982	Orn Lys Arg decarboxylase major
FG381_04685	COG0531	amino acid
FG381_04690	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FG381_04690	COG0731	radical SAM domain protein
FG381_04695	COG0531	amino acid
FG381_04710	COG2801	Transposase and inactivated derivatives
FG381_04725	COG1473	amidohydrolase
FG381_04730	COG1047	Peptidyl-prolyl cis-trans
FG381_04735	COG1280	lysine exporter protein (LysE YggA)
FG381_04750	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FG381_04760	COG1994	Peptidase M50
FG381_04770	COG1322	Protein conserved in bacteria
FG381_04775	COG4651	solute:proton antiporter activity
FG381_04775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FG381_04800	COG1129	ABC transporter
FG381_04820	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FG381_04820	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FG381_04825	COG0584	glycerophosphoryl diester phosphodiesterase
FG381_04835	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FG381_04840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FG381_04845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FG381_04850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FG381_04870	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FG381_04880	COG1966	Carbon starvation protein
FG381_04905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FG381_04910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FG381_04915	COG0765	amino acid transport
FG381_04920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FG381_04925	COG1185	polyribonucleotide nucleotidyltransferase activity
FG381_04930	COG0149	triose-phosphate isomerase activity
FG381_04965	COG0210	DNA helicase
FG381_04970	COG0495	leucyl-tRNA aminoacylation
FG381_04980	COG1466	dna polymerase III delta subunit
FG381_04985	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FG381_05000	COG0371	Dehydrogenase
FG381_05005	COG0335	large ribosomal subunit rRNA binding
FG381_05010	COG0336	Belongs to the RNA methyltransferase TrmD family
FG381_05015	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FG381_05020	COG0228	four-way junction DNA binding
FG381_05025	COG4149	molybdate abc transporter
FG381_05050	COG1238	metal cluster binding
FG381_05060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FG381_05075	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FG381_05090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FG381_05110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FG381_05125	COG1120	ATPase activity
FG381_05130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FG381_05135	COG0473	3-isopropylmalate dehydrogenase activity
FG381_05145	COG0066	3-isopropylmalate dehydratase activity
FG381_05165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FG381_05185	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FG381_05195	COG2814	Major facilitator Superfamily
FG381_05235	COG1022	Amp-dependent synthetase and ligase
FG381_05240	COG1022	Amp-dependent synthetase and ligase
FG381_05245	COG0516	GMP reductase activity
FG381_05245	COG0517	IMP dehydrogenase activity
FG381_05250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FG381_05250	COG0519	Catalyzes the synthesis of GMP from XMP
FG381_05255	COG2195	Cleaves the N-terminal amino acid of tripeptides
FG381_05260	COG0252	asparaginase activity
FG381_05265	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FG381_05270	COG3069	C4-dicarboxylate transmembrane transporter activity
FG381_05290	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FG381_05300	COG1472	Belongs to the glycosyl hydrolase 3 family
FG381_05305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FG381_05310	COG1381	Involved in DNA repair and RecF pathway recombination
FG381_05315	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FG381_05320	COG0571	ribonuclease III activity
FG381_05325	COG0681	Belongs to the peptidase S26 family
FG381_05330	COG0481	GTPase activity
FG381_05335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FG381_05340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FG381_05345	COG1028	Short-chain dehydrogenase reductase Sdr
FG381_05355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FG381_05360	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FG381_05395	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FG381_05400	COG1027	Aspartate ammonia-lyase
FG381_05405	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FG381_05410	COG1053	succinate dehydrogenase
FG381_05415	COG0251	oxidation-reduction process
FG381_05420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FG381_05425	COG0583	DNA-binding transcription factor activity
FG381_05430	COG0628	permease
FG381_05435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FG381_05435	COG1017	nitric oxide dioxygenase activity
FG381_05445	COG1760	l-serine dehydratase
FG381_05450	COG3069	C4-dicarboxylate transmembrane transporter activity
FG381_05455	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FG381_05465	COG1162	GTPase activity
FG381_05470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FG381_05475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FG381_05480	COG0747	negative chemotaxis
FG381_05500	COG0542	response to heat
FG381_05505	COG0314	molybdopterin synthase activity
FG381_05510	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FG381_05515	COG0303	'Molybdopterin
FG381_05520	COG1763	Mo-molybdopterin cofactor biosynthetic process
FG381_05530	COG1053	succinate dehydrogenase
FG381_05530	COG3976	FMN-binding domain protein
FG381_05585	COG4372	Transposase
FG381_05615	COG1473	amidohydrolase
FG381_05630	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FG381_05635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FG381_05640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FG381_05645	COG1074	ATP-dependent DNA helicase activity
FG381_05650	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FG381_05655	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FG381_05665	COG0305	Participates in initiation and elongation during chromosome replication
FG381_05670	COG0359	binds to the 23S rRNA
FG381_05675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FG381_05695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FG381_05700	COG0557	exoribonuclease II activity
FG381_05720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FG381_05725	COG1397	ADP-ribosylglycohydrolase
FG381_05735	COG4372	Transposase
FG381_05760	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FG381_05765	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FG381_05775	COG0330	HflC and HflK could
FG381_05780	COG0330	HflC and HflK could
FG381_05795	COG2223	nitrite transmembrane transporter activity
FG381_05805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FG381_05810	COG1923	regulation of RNA biosynthetic process
FG381_05815	COG1160	GTP binding
FG381_05820	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FG381_05825	COG2976	Protein conserved in bacteria
FG381_05835	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FG381_05845	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FG381_05850	COG0105	UTP biosynthetic process
FG381_05855	COG1605	Chorismate mutase
FG381_05855	COG0287	Prephenate dehydrogenase
FG381_05865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FG381_05880	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FG381_05895	COG0704	Plays a role in the regulation of phosphate uptake
FG381_05905	COG0581	inorganic phosphate transmembrane transporter activity
FG381_05910	COG0573	inorganic phosphate transmembrane transporter activity
FG381_05915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FG381_05925	COG0776	regulation of translation
FG381_05935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FG381_05940	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FG381_05945	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FG381_05950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FG381_05955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FG381_05970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FG381_05975	COG2801	Transposase and inactivated derivatives
FG381_06000	COG2801	Transposase and inactivated derivatives
FG381_06050	COG2848	UPF0210 protein
FG381_06065	COG1136	(ABC) transporter
FG381_06080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FG381_06090	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FG381_06120	COG0667	Aldo Keto reductase
FG381_06125	COG2249	NAD(P)H dehydrogenase (quinone) activity
FG381_06130	COG2975	iron-sulfur cluster assembly
FG381_06135	COG0633	Ferredoxin
FG381_06140	COG0443	Heat shock 70 kDa protein
FG381_06145	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FG381_06150	COG0316	Belongs to the HesB IscA family
FG381_06155	COG0822	iron-sulfur transferase activity
FG381_06160	COG1104	cysteine desulfurase activity
FG381_06165	COG1959	2 iron, 2 sulfur cluster binding
FG381_06170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FG381_06175	COG0556	nucleotide-excision repair
FG381_06190	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FG381_06215	COG0746	molybdenum cofactor guanylyltransferase activity
FG381_06220	COG0303	'Molybdopterin
FG381_06225	COG2129	metallophosphoesterase
FG381_06235	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FG381_06240	COG1674	ftsk spoiiie
FG381_06245	COG0492	ferredoxin-NADP+ reductase activity
FG381_06255	COG2860	membrane
FG381_06260	COG0347	Belongs to the P(II) protein family
FG381_06270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FG381_06275	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FG381_06280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FG381_06285	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FG381_06290	COG1534	Rna-binding protein
FG381_06295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FG381_06305	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FG381_06315	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FG381_06325	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FG381_06335	COG3118	belongs to the thioredoxin family
FG381_06340	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FG381_06350	COG0181	hydroxymethylbilane synthase activity
FG381_06355	COG0254	rRNA binding
FG381_06365	COG0534	Mate efflux family protein
FG381_06370	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FG381_06370	COG0731	radical SAM domain protein
FG381_06375	COG0501	Belongs to the peptidase M48B family
FG381_06380	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FG381_06390	COG0776	regulation of translation
FG381_06400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FG381_06405	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FG381_06415	COG0402	S-adenosylhomocysteine deaminase activity
FG381_06425	COG0546	phosphoglycolate phosphatase activity
FG381_06440	COG0437	4 iron, 4 sulfur cluster binding
FG381_06500	COG0802	atpase or kinase
FG381_06505	COG0860	N-Acetylmuramoyl-L-alanine amidase
FG381_06515	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FG381_06520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FG381_06525	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FG381_06530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FG381_06535	COG0009	L-threonylcarbamoyladenylate synthase
FG381_06550	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FG381_06560	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FG381_06595	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FG381_06620	COG0308	aminopeptidase N
FG381_06625	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FG381_06670	COG0424	maF-like protein
FG381_06675	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FG381_06680	COG0799	negative regulation of ribosome biogenesis
FG381_06685	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FG381_06700	COG0217	transcriptional regulatory protein
FG381_06705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FG381_06710	COG2197	response regulator
FG381_06715	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FG381_06720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FG381_06735	COG0443	Heat shock 70 kDa protein
FG381_06745	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FG381_06760	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FG381_06770	COG3118	belongs to the thioredoxin family
FG381_06785	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FG381_06795	COG0318	PFAM AMP-dependent synthetase and ligase
FG381_06805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FG381_06815	COG1346	cytolysis
FG381_06820	COG2070	2-Nitropropane dioxygenase
FG381_06830	COG0861	Integral membrane protein TerC family
FG381_06835	COG2137	regulation of response to DNA damage stimulus
FG381_06840	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FG381_06860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FG381_06865	COG2011	ABC-type metal ion transport system permease component
FG381_06875	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FG381_06880	COG1968	undecaprenyl-diphosphatase activity
FG381_06885	COG3318	Belongs to the UPF0149 family
FG381_06885	COG3012	SEC-C Motif Domain Protein
FG381_06890	COG0488	(ABC) transporter
FG381_06920	COG0315	cyclic pyranopterin monophosphate synthase activity
FG381_06925	COG4783	chaperone-mediated protein folding
FG381_06930	COG0492	ferredoxin-NADP+ reductase activity
FG381_06935	COG0489	protein tyrosine kinase activity
FG381_06945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FG381_06945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FG381_06950	COG0659	secondary active sulfate transmembrane transporter activity
FG381_06970	COG0848	biopolymer transport protein
FG381_06975	COG0811	peptide transport
FG381_06980	COG4771	TonB-dependent receptor
FG381_06985	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FG381_06990	COG4605	iron ion homeostasis
FG381_06995	COG4604	ABC transporter, ATP-binding protein
FG381_07000	COG4607	ABC-type enterochelin transport system periplasmic component
FG381_07010	COG0281	malic enzyme
FG381_07025	COG0823	Involved in the tonB-independent uptake of proteins
FG381_07035	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FG381_07040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FG381_07045	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FG381_07055	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FG381_07060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FG381_07065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FG381_07070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FG381_07085	COG0751	glycine-tRNA ligase activity
FG381_07090	COG0752	glycyl-tRNA synthetase alpha subunit
FG381_07095	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FG381_07100	COG4535	Mg2 and Co2 transporter CorC
FG381_07105	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FG381_07110	COG1702	phosphate starvation-inducible protein PhoH
FG381_07135	COG0859	PFAM glycosyl transferase family 9
FG381_07150	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FG381_07155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FG381_07160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FG381_07165	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FG381_07170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FG381_07175	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FG381_07190	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FG381_07205	COG1752	Esterase of the alpha-beta hydrolase superfamily
FG381_07215	COG1943	Transposase
FG381_07220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FG381_07235	COG2814	Major facilitator Superfamily
FG381_07240	COG0629	single-stranded DNA binding
FG381_07250	COG2217	Heavy metal translocating P-type atpase
FG381_07255	COG1136	(ABC) transporter
FG381_07255	COG0577	efflux transmembrane transporter activity
FG381_07260	COG0577	efflux transmembrane transporter activity
FG381_07260	COG1136	(ABC) transporter
FG381_07275	COG0745	RESPONSE REGULATOR receiver
FG381_07280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FG381_07295	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FG381_07325	COG0235	Class ii aldolase
FG381_07330	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FG381_07335	COG1042	CoA-binding domain protein
FG381_07335	COG0045	succinate-CoA ligase (ADP-forming) activity
FG381_07335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FG381_07340	COG1250	3-hydroxyacyl-CoA dehydrogenase
FG381_07340	COG1024	Enoyl-CoA hydratase
FG381_07345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FG381_07350	COG0765	amino acid transport
FG381_07355	COG0765	amino acid transport
FG381_07360	COG1126	abc transporter atp-binding protein
FG381_07370	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FG381_07385	COG1137	ATPase activity
FG381_07390	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FG381_07395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FG381_07400	COG1660	Displays ATPase and GTPase activities
FG381_07405	COG1194	a g-specific adenine glycosylase
FG381_07420	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FG381_07430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FG381_07435	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FG381_07440	COG0513	Belongs to the DEAD box helicase family
FG381_07445	COG0193	aminoacyl-tRNA hydrolase activity
FG381_07450	COG1683	Conserved Protein
FG381_07455	COG0012	GTP binding
FG381_07465	COG0450	alkyl hydroperoxide reductase
FG381_07480	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FG381_07485	COG0742	ribosomal rna small subunit methyltransferase
FG381_07500	COG2884	Cell division ATP-binding protein ftsE
FG381_07510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FG381_07515	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FG381_07520	COG2197	response regulator
FG381_07525	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FG381_07530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FG381_07540	COG0793	Belongs to the peptidase S41A family
FG381_07545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FG381_07550	COG0616	signal peptide processing
FG381_07560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FG381_07565	COG0523	cobalamin synthesis protein
FG381_07575	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FG381_07580	COG1560	Kdo2-lipid A biosynthetic process
FG381_07590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FG381_07600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FG381_07610	COG0741	lytic transglycosylase activity
FG381_07615	COG0617	tRNA 3'-terminal CCA addition
FG381_07635	COG0517	IMP dehydrogenase activity
FG381_07635	COG0516	GMP reductase activity
FG381_07645	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FG381_07665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FG381_07670	COG1022	Amp-dependent synthetase and ligase
FG381_07675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FG381_07680	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FG381_07680	COG4624	Iron only hydrogenase large subunit, C-terminal domain
FG381_07695	COG1160	GTP binding
FG381_07700	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FG381_07705	COG2233	PERMEase
FG381_07710	COG2183	response to ionizing radiation
FG381_07720	COG0765	amino acid transport
FG381_07725	COG4597	amino acid ABC transporter
FG381_07730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FG381_07735	COG1253	flavin adenine dinucleotide binding
FG381_07750	COG0242	peptide deformylase activity
FG381_07755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FG381_07760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FG381_07765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FG381_07765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FG381_07775	COG5000	phosphorelay sensor kinase activity
FG381_07780	COG2204	response regulator
FG381_07785	COG0569	domain protein
FG381_07790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FG381_07810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FG381_07820	COG2211	Major facilitator Superfamily
FG381_07825	COG1187	pseudouridine synthase activity
FG381_07830	COG0708	Exodeoxyribonuclease III
FG381_07835	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FG381_07840	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FG381_07845	COG0154	amidase activity
FG381_07850	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FG381_07855	COG1077	Cell shape determining protein MreB Mrl
FG381_07870	COG0768	penicillin binding
FG381_07875	COG0772	Belongs to the SEDS family
FG381_07880	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FG381_07885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FG381_07905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FG381_07910	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FG381_07910	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FG381_07920	COG2921	Belongs to the UPF0250 family
FG381_07960	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FG381_07970	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FG381_07985	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FG381_07990	COG0445	tRNA wobble uridine modification
FG381_07995	COG0357	Ribosomal RNA small subunit methyltransferase G
FG381_08005	COG1192	Involved in chromosome partitioning
FG381_08010	COG1475	DNA binding
FG381_08020	COG0356	it plays a direct role in the translocation of protons across the membrane
FG381_08035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FG381_08050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FG381_08055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FG381_08065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FG381_08070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FG381_08085	COG2226	methyltransferase
FG381_08100	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FG381_08105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FG381_08135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FG381_08140	COG0642	Histidine kinase
FG381_08145	COG0745	RESPONSE REGULATOR receiver
FG381_08160	COG4681	YaeQ
FG381_08165	COG2346	COG2346, Truncated hemoglobins
FG381_08175	COG1294	oxidase, subunit
FG381_08210	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FG381_08215	COG0674	pyruvate-flavodoxin oxidoreductase activity
FG381_08220	COG1013	pyruvate-flavodoxin oxidoreductase activity
FG381_08225	COG0493	'glutamate synthase
FG381_08230	COG3850	Histidine kinase
FG381_08235	COG2197	response regulator
FG381_08245	COG0348	domain, Protein
FG381_08250	COG0437	4 iron, 4 sulfur cluster binding
FG381_08255	COG0243	molybdopterin cofactor binding
FG381_08270	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FG381_08275	COG0514	ATP-dependent DNA helicase (RecQ)
FG381_08285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FG381_08300	COG1469	GTP cyclohydrolase I activity
FG381_08310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FG381_08330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FG381_08340	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FG381_08355	COG0081	regulation of translation
FG381_08360	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FG381_08365	COG0222	ribosome binding
FG381_08370	COG0085	RNA polymerase activity
FG381_08375	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FG381_08380	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FG381_08385	COG0049	tRNA binding
FG381_08395	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FG381_08400	COG0051	transcription antitermination factor activity, RNA binding
FG381_08405	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FG381_08410	COG0088	Forms part of the polypeptide exit tunnel
FG381_08415	COG0089	rRNA binding
FG381_08420	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FG381_08425	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FG381_08430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FG381_08440	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FG381_08445	COG0255	Belongs to the universal ribosomal protein uL29 family
FG381_08455	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FG381_08460	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FG381_08465	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FG381_08470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FG381_08480	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FG381_08485	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FG381_08490	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FG381_08495	COG1841	ribosomal large subunit assembly
FG381_08500	COG0200	Binds to the 23S rRNA
FG381_08505	COG0201	protein transport
FG381_08510	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FG381_08515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FG381_08520	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FG381_08535	COG0203	ribosomal protein L17
FG381_08540	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FG381_08555	COG0516	GMP reductase activity
FG381_08570	COG1965	Belongs to the frataxin family
FG381_08585	COG1127	ABC transporter
FG381_08590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FG381_08595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FG381_08600	COG2853	Lipoprotein
FG381_08615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FG381_08625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FG381_08635	COG0805	protein transport
FG381_08645	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FG381_08650	COG0625	glutathione transferase activity
FG381_08685	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FG381_08690	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FG381_08700	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FG381_08715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FG381_08740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FG381_08810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FG381_08850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FG381_08855	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FG381_08860	COG2095	MarC family integral membrane protein
FG381_08865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FG381_08870	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FG381_08875	COG0316	Belongs to the HesB IscA family
FG381_08880	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FG381_08895	COG1490	D-aminoacyl-tRNA deacylase activity
FG381_08905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FG381_08910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FG381_08915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FG381_08915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FG381_08920	COG0307	riboflavin synthase, alpha
FG381_08925	COG1902	pentaerythritol trinitrate reductase activity
FG381_08935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FG381_08940	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FG381_08945	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FG381_08950	COG1058	Belongs to the CinA family
FG381_08950	COG1546	Belongs to the CinA family
FG381_08955	COG1253	flavin adenine dinucleotide binding
FG381_08980	COG0284	orotidine-5'-phosphate decarboxylase activity
FG381_08990	COG0459	protein refolding
FG381_08995	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FG381_09005	COG4232	protein-disulfide reductase activity
FG381_09010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FG381_09025	COG2001	Belongs to the MraZ family
FG381_09045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FG381_09050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FG381_09055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FG381_09060	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FG381_09070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FG381_09075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FG381_09080	COG1181	Belongs to the D-alanine--D-alanine ligase family
FG381_09085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FG381_09095	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FG381_09100	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FG381_09110	COG0653	protein targeting
FG381_09125	COG1943	Transposase
FG381_09145	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FG381_09155	COG0237	dephospho-CoA kinase activity
FG381_09165	COG0142	geranyltranstransferase activity
FG381_09170	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FG381_09175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FG381_09180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FG381_09185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FG381_09190	COG0442	prolyl-tRNA aminoacylation
FG381_09205	COG0848	biopolymer transport protein
FG381_09215	COG0824	Thioesterase
FG381_09230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FG381_09240	COG2255	four-way junction helicase activity
FG381_09245	COG0501	Belongs to the peptidase M48B family
FG381_09250	COG0632	four-way junction helicase activity
FG381_09255	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FG381_09260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FG381_09275	COG3023	N-Acetylmuramoyl-L-alanine amidase
FG381_09280	COG0762	integral membrane protein
FG381_09295	COG2264	protein methyltransferase activity
FG381_09305	COG0439	Biotin carboxylase
FG381_09310	COG0511	ligase activity, forming carbon-carbon bonds
FG381_09320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FG381_09330	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FG381_09335	COG2239	Acts as a magnesium transporter
FG381_09350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FG381_09355	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FG381_09360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FG381_09365	COG2755	lipolytic protein G-D-S-L family
FG381_09365	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FG381_09370	COG0126	phosphoglycerate kinase activity
FG381_09375	COG2195	Cleaves the N-terminal amino acid of tripeptides
FG381_09380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FG381_09385	COG0586	Pfam SNARE associated Golgi protein
FG381_09390	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FG381_09395	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FG381_09400	COG2194	sulfuric ester hydrolase activity
FG381_09405	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FG381_09420	COG0617	tRNA 3'-terminal CCA addition
FG381_09425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FG381_09445	COG0521	Mo-molybdopterin cofactor biosynthetic process
FG381_09450	COG3028	Belongs to the UPF0307 family
FG381_09455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FG381_09460	COG0343	queuine tRNA-ribosyltransferase activity
FG381_09465	COG1862	Preprotein translocase
FG381_09470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FG381_09500	COG2194	sulfuric ester hydrolase activity
FG381_09505	COG0352	thiamine-phosphate diphosphorylase activity
FG381_09515	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FG381_09520	COG0730	response to heat
FG381_09540	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FG381_09555	COG0328	RNA-DNA hybrid ribonuclease activity
FG381_09585	COG0497	DNA recombination
FG381_09600	COG1132	(ABC) transporter
FG381_09605	COG0697	spore germination
FG381_09620	COG1530	ribonuclease E activity
FG381_09625	COG2925	Exonuclease
FG381_09635	COG2084	Dehydrogenase
FG381_09640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FG381_09650	COG1477	protein flavinylation
FG381_09660	COG0463	Glycosyl transferase, family 2
FG381_09660	COG1216	Glycosyl transferase, family 2
FG381_09665	COG1442	glycosyl transferase family 8
FG381_09670	COG2801	Transposase and inactivated derivatives
FG381_09690	COG1115	amino acid carrier protein
FG381_09695	COG0165	Argininosuccinate lyase
FG381_09725	COG0525	valine-tRNA ligase activity
FG381_09745	COG1053	succinate dehydrogenase
FG381_09745	COG3976	FMN-binding domain protein
FG381_09760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FG381_09765	COG1758	RNA polymerase activity
FG381_09770	COG0194	GDP metabolic process
FG381_09775	COG1561	YicC-like family, N-terminal region
FG381_09780	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FG381_09785	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FG381_09790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FG381_09800	COG3852	Histidine kinase
FG381_09815	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FG381_09845	COG0708	Exodeoxyribonuclease III
FG381_09855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FG381_09865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FG381_09880	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FG381_09885	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FG381_09890	COG1643	Atp-dependent helicase
FG381_09900	COG0247	lactate metabolic process
FG381_09900	COG2181	nitrate reductase activity
FG381_09910	COG0167	dihydroorotate dehydrogenase activity
FG381_09915	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FG381_09945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FG381_09960	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FG381_09965	COG1187	pseudouridine synthase activity
FG381_09975	COG0779	Required for maturation of 30S ribosomal subunits
FG381_09980	COG0195	Participates in both transcription termination and antitermination
FG381_09980	COG2251	uridine kinase activity
FG381_09985	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FG381_09990	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FG381_09995	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FG381_10005	COG3012	SEC-C Motif Domain Protein
FG381_10010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FG381_10025	COG0583	DNA-binding transcription factor activity
FG381_10030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FG381_10055	COG0277	FAD linked oxidase domain protein
FG381_10060	COG0563	adenylate kinase activity
FG381_10080	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FG381_10085	COG1663	tetraacyldisaccharide 4'-kinase activity
FG381_10085	COG2835	tetraacyldisaccharide 4'-kinase activity
FG381_10090	COG1663	tetraacyldisaccharide 4'-kinase activity
FG381_10100	COG3976	FMN-binding domain protein
FG381_10100	COG1053	succinate dehydrogenase
FG381_10100	COG0431	NADPH-dependent FMN reductase
FG381_10105	COG1570	exodeoxyribonuclease VII activity
FG381_10110	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FG381_10115	COG0431	NADPH-dependent FMN reductase
FG381_10115	COG1053	succinate dehydrogenase
FG381_10115	COG3976	FMN-binding domain protein
FG381_10135	COG0679	Auxin Efflux Carrier
FG381_10160	COG1373	ATPase (AAA superfamily
FG381_10170	COG0756	dUTP diphosphatase activity
FG381_10175	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FG381_10185	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FG381_10190	COG0196	riboflavin kinase activity
FG381_10195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FG381_10200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FG381_10200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FG381_10215	COG1283	sodium-dependent phosphate transmembrane transporter activity
FG381_10240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FG381_10245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FG381_10250	COG0477	Major facilitator Superfamily
FG381_10255	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FG381_10265	COG1610	YqeY-like protein
FG381_10280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FG381_10290	COG0513	Belongs to the DEAD box helicase family
FG381_10300	COG0471	metal ion transport
FG381_10310	COG2205	protein histidine kinase activity
FG381_10315	COG0745	RESPONSE REGULATOR receiver
FG381_10325	COG1214	PFAM Peptidase M22, glycoprotease
FG381_10335	COG1573	uracil-dna glycosylase
FG381_10345	COG4145	pantothenate transmembrane transporter activity
FG381_10355	COG0133	tryptophan synthase activity
FG381_10360	COG0134	indole-3-glycerol-phosphate synthase activity
FG381_10360	COG0135	phosphoribosylanthranilate isomerase activity
FG381_10365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FG381_10380	COG0288	reversible hydration of carbon dioxide
FG381_10400	COG0252	asparaginase activity
FG381_10410	COG0137	argininosuccinate synthase activity
FG381_10425	COG1943	Transposase
FG381_10435	COG0504	CTP synthase activity
FG381_10440	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FG381_10445	COG0148	phosphopyruvate hydratase activity
FG381_10450	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FG381_10455	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FG381_10460	COG0613	PHP domain protein
FG381_10465	COG1115	amino acid carrier protein
FG381_10490	COG0778	Nitroreductase
FG381_10500	COG1199	ATP-dependent helicase activity
FG381_10515	COG0733	neurotransmitter:sodium symporter activity
FG381_10520	COG0733	neurotransmitter:sodium symporter activity
FG381_10525	COG0733	neurotransmitter:sodium symporter activity
FG381_10530	COG0733	neurotransmitter:sodium symporter activity
FG381_10545	COG4178	(ABC) transporter
FG381_10565	COG1183	phosphatidylcholine synthase activity
FG381_10575	COG0697	spore germination
FG381_10585	COG2951	lytic endotransglycosylase activity
FG381_10600	COG1414	Transcriptional regulator
FG381_10605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FG381_10610	COG0129	dihydroxy-acid dehydratase activity
FG381_10615	COG2610	gluconate transmembrane transporter activity
FG381_10640	COG0564	pseudouridine synthase activity
FG381_10650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FG381_10680	COG1943	Transposase
FG381_10690	COG0101	tRNA pseudouridine synthase activity
FG381_10720	COG0285	dihydrofolate synthase activity
FG381_10730	COG1286	toxin biosynthetic process
FG381_10735	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FG381_10755	COG4953	penicillin-binding protein 1C
FG381_10775	COG0679	Auxin Efflux Carrier
FG381_10815	COG0424	maF-like protein
FG381_10820	COG1399	metal-binding, possibly nucleic acid-binding protein
FG381_10830	COG2223	nitrite transmembrane transporter activity
FG381_10835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FG381_10840	COG3069	C4-dicarboxylate transmembrane transporter activity
FG381_10850	COG1473	amidohydrolase
FG381_10855	COG2188	Transcriptional regulator
FG381_10870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FG381_10880	COG1114	Component of the transport system for branched-chain amino acids
FG381_10885	COG0402	S-adenosylhomocysteine deaminase activity
FG381_10900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FG381_10900	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FG381_10910	COG1045	serine acetyltransferase
FG381_10920	COG3713	MltA-interacting MipA family protein
FG381_10925	COG3177	Filamentation induced by cAMP protein fic
FG381_10940	COG0848	biopolymer transport protein
FG381_10945	COG0811	peptide transport
FG381_10960	COG1129	ABC transporter
FG381_10975	COG4771	TonB-dependent receptor
FG381_10985	COG1321	iron dependent repressor
FG381_10995	COG1131	(ABC) transporter
FG381_11000	COG0842	Transport permease protein
FG381_11010	COG1053	succinate dehydrogenase
FG381_11010	COG3976	FMN-binding domain protein
FG381_11020	COG1464	Belongs to the NlpA lipoprotein family
FG381_11025	COG4948	Mandelate Racemase Muconate Lactonizing
FG381_11040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FG381_11045	COG1126	abc transporter atp-binding protein
FG381_11050	COG0765	amino acid transport
FG381_11070	COG0165	Argininosuccinate lyase
FG381_11075	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FG381_11080	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FG381_11090	COG0024	Methionine aminopeptidase
FG381_11100	COG0052	Belongs to the universal ribosomal protein uS2 family
FG381_11105	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FG381_11115	COG0233	cytoplasmic translational termination
FG381_11120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FG381_11125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FG381_11135	COG3069	C4-dicarboxylate transmembrane transporter activity
FG381_11150	COG0575	Belongs to the CDS family
FG381_11155	COG1739	Uncharacterized protein family UPF0029
FG381_11160	COG1408	metallophosphoesterase
FG381_11165	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FG381_11170	COG0750	zinc metalloprotease
FG381_11180	COG1115	amino acid carrier protein
FG381_11185	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FG381_11195	COG0753	catalase activity
FG381_11215	COG0826	peptidase U32
FG381_11225	COG0084	hydrolase, TatD family'
FG381_11250	COG1053	succinate dehydrogenase
FG381_11255	COG1053	succinate dehydrogenase
FG381_11305	COG0493	'glutamate synthase
FG381_11315	COG3381	protein complex oligomerization
FG381_11325	COG0437	4 iron, 4 sulfur cluster binding
FG381_11330	COG0243	molybdopterin cofactor binding
FG381_11345	COG2843	Capsule synthesis protein
FG381_11350	COG3468	outer membrane autotransporter barrel domain protein
FG381_11370	COG2801	Transposase and inactivated derivatives
FG381_11405	COG1205	dead DEAH box helicase
FG381_11405	COG1111	helicase
FG381_11410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FG381_11435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FG381_11435	COG1017	nitric oxide dioxygenase activity
FG381_11440	COG2801	Transposase and inactivated derivatives
FG381_11455	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FG381_11460	COG4566	intracellular signal transduction
FG381_11475	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FG381_11480	COG1464	Belongs to the NlpA lipoprotein family
FG381_11485	COG0656	L-ascorbic acid biosynthetic process
FG381_11495	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FG381_11500	COG0531	amino acid
FG381_11525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FG381_11540	COG1295	ribonuclease BN
FG381_11550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FG381_11555	COG2917	probably involved in intracellular septation
FG381_11560	COG0612	Peptidase, M16
FG381_11565	COG2249	NAD(P)H dehydrogenase (quinone) activity
FG381_11570	COG2153	protein acetylation
FG381_11580	COG0560	Phosphoserine phosphatase
FG381_11585	COG1053	succinate dehydrogenase
FG381_11590	COG0758	DNA mediated transformation
FG381_11605	COG1053	succinate dehydrogenase
FG381_11660	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FG381_11670	COG0037	tRNA processing
FG381_11680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FG381_11725	COG2814	Major facilitator Superfamily
FG381_11730	COG1309	transcriptional regulator
FG381_11735	COG1280	lysine exporter protein (LysE YggA)
FG381_11840	COG1724	mRNA binding
FG381_11845	COG1598	PFAM Uncharacterised protein family UPF0150
FG381_11885	COG4626	Terminase
FG381_11885	COG1802	Transcriptional regulator
FG381_11925	COG4386	tail sheath protein
FG381_11975	COG3299	homolog of phage Mu protein gp47
FG381_11990	COG0582	viral genome integration into host DNA
FG381_12070	COG2801	Transposase and inactivated derivatives
FG381_12085	COG0729	surface antigen
FG381_12110	COG3069	C4-dicarboxylate transmembrane transporter activity
FG381_12115	COG1966	Carbon starvation protein
FG381_12125	COG2814	Major facilitator Superfamily
FG381_12150	COG3875	lactate racemase activity
FG381_12165	COG0439	Biotin carboxylase
FG381_12175	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FG381_12190	COG1757	Na H antiporter
FG381_12195	COG0069	glutamate synthase activity
FG381_12195	COG0067	glutamate synthase
FG381_12195	COG0070	glutamate synthase
FG381_12210	COG0471	metal ion transport
FG381_12215	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FG381_12215	COG0352	thiamine-phosphate diphosphorylase activity
FG381_12215	COG0351	phosphomethylpyrimidine kinase
FG381_12230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FG381_12230	COG0047	phosphoribosylformylglycinamidine synthase activity
FG381_12235	COG1982	Orn Lys Arg decarboxylase major
FG381_12255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FG381_12255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FG381_12260	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FG381_12295	COG0765	amino acid transport
FG381_12305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FG381_12345	COG4566	intracellular signal transduction
FG381_12350	COG4191	Histidine kinase
FG381_12355	COG1053	succinate dehydrogenase
FG381_12355	COG3976	FMN-binding domain protein
FG381_12395	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FG381_12400	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FG381_12405	COG0375	protein maturation
FG381_12425	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family