locus-tag	class	description
E3D00_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
E3D00_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
E3D00_00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
E3D00_00020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E3D00_00030	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
E3D00_00035	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
E3D00_00040	ENOG4105CQB	FAD linked oxidase domain protein
E3D00_00060	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
E3D00_00075	ENOG4105DUX	Transporter
E3D00_00080	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
E3D00_00085	ENOG4105F8V	Hydrolase, tatD family
E3D00_00090	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
E3D00_00100	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
E3D00_00105	ENOG4105DZ1	carboxypeptidase
E3D00_00115	ENOG4105CVE	Lytic murein transglycosylase
E3D00_00135	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
E3D00_00140	ENOG4105CUB	amino acid
E3D00_00165	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
E3D00_00175	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
E3D00_00180	ENOG4105CUT	histidyl-tRNA synthetase
E3D00_00185	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
E3D00_00200	ENOG4105CFH	Aspartokinase
E3D00_00205	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
E3D00_00240	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
E3D00_00250	ENOG4105M85	Bola protein
E3D00_00285	ENOG4105CB5	ATP-dependent DNA helicase recG
E3D00_00295	ENOG4105VEQ	Cold shock protein
E3D00_00300	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
E3D00_00305	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
E3D00_00310	ENOG4105CQC	Prephenate dehydratase
E3D00_00315	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
E3D00_00325	ENOG4108JQ1	Dehydrogenase
E3D00_00330	ENOG4105C0P	Mg chelatase subunit ChlI
E3D00_00335	ENOG4105C28	cystathionine
E3D00_00340	ENOG4105KHC	sulfurtransferase
E3D00_00345	ENOG4105IPI	Membrane
E3D00_00355	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
E3D00_00360	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
E3D00_00365	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E3D00_00375	ENOG4107UIS	Involved in DNA repair and RecF pathway recombination (By similarity)
E3D00_00380	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
E3D00_00385	ENOG4105CE9	30S ribosomal protein S2
E3D00_00390	ENOG4105C0B	DNA polymerase III (alpha subunit)
E3D00_00395	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
E3D00_00400	ENOG4105D60	lipoprotein releasing system transmembrane protein
E3D00_00405	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
E3D00_00415	ENOG4107QNB	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
E3D00_00420	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
E3D00_00430	ENOG4105K70	DNA-binding protein
E3D00_00435	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
E3D00_00440	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
E3D00_00445	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
E3D00_00450	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
E3D00_00470	ENOG4105C1J	atp-dependent rna helicase
E3D00_00475	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
E3D00_00480	ENOG4108Z4V	iron-sulfur cluster assembly
E3D00_00485	ENOG4105VG1	fes assembly suf system protein
E3D00_00495	ENOG4105JRK	feS assembly protein SufD
E3D00_00500	ENOG4105C3K	feS assembly ATPase SufC
E3D00_00515	ENOG4106BRA	Membrane
E3D00_00530	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
E3D00_00535	ENOG4105KDC	50s ribosomal protein l28
E3D00_00540	ENOG4108JJ7	ABC transporter
E3D00_00550	ENOG4105IPI	Membrane
E3D00_00565	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
E3D00_00570	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
E3D00_00575	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
E3D00_00580	ENOG41082R8	50S ribosomal protein l32
E3D00_00595	ENOG4105E0F	Histidine kinase
E3D00_00600	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
E3D00_00610	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
E3D00_00615	ENOG4105K5G	30S ribosomal protein S21
E3D00_00625	ENOG4107RD7	Flagellar Motor Protein, MotA
E3D00_00630	ENOG4105ER2	Ompa motb domain protein
E3D00_00645	ENOG4105F7P	transcriptional regulator AsnC family
E3D00_00650	ENOG4105C3M	thioredoxin reductase
E3D00_00655	ENOG4108MP6	LysR family Transcriptional regulator
E3D00_00660	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
E3D00_00665	ENOG4105D07	Signal peptide peptidase, SppA
E3D00_00675	ENOG4105DSW	Fusaric acid resistance protein
E3D00_00720	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
E3D00_00725	ENOG4105K46	50S ribosomal protein l27
E3D00_00730	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E3D00_00735	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
E3D00_00745	ENOG4105Y2X	UPF0335 protein
E3D00_00750	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
E3D00_00770	ENOG4107YUR	Cell division protein mraZ
E3D00_00775	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
E3D00_00790	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
E3D00_00800	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
E3D00_00805	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
E3D00_00815	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
E3D00_00820	ENOG4105DFU	Cell wall formation (By similarity)
E3D00_00825	ENOG4105D4A	Cell wall formation (By similarity)
E3D00_00830	ENOG4105CPF	Cell wall formation (By similarity)
E3D00_00835	ENOG4108UFP	Essential cell division protein (By similarity)
E3D00_00840	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
E3D00_00850	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E3D00_00855	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3D00_00860	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
E3D00_00865	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
E3D00_00870	ENOG4105C37	(CBS) domain
E3D00_00875	ENOG4108RWI	nicotinamidase
E3D00_00890	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
E3D00_00905	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
E3D00_00910	ENOG4105CUV	Homoserine Kinase
E3D00_00915	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
E3D00_00925	ENOG4105EPD	Oligopeptide transporter, Opt family
E3D00_00960	ENOG4105CHM	Aminotransferase
E3D00_00965	ENOG4105CHM	Aminotransferase
E3D00_00970	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
E3D00_00975	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
E3D00_00980	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
E3D00_00985	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
E3D00_00990	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
E3D00_00995	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
E3D00_01000	ENOG4105K5M	30s ribosomal protein S16
E3D00_01005	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3D00_01065	ENOG4106VK6	Flagellar motor protein
E3D00_01080	ENOG4105CS6	Rhs element vgr protein
E3D00_01090	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E3D00_01140	ENOG4105C1J	atp-dependent rna helicase
E3D00_01145	ENOG4105DWV	Homoserine O-trans-acetylase
E3D00_01150	ENOG4105DWV	Homoserine O-trans-acetylase
E3D00_01205	ENOG4107VXZ	Hydrolase
E3D00_01275	ENOG4105D48	metallophosphoesterase
E3D00_01280	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
E3D00_01320	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
E3D00_01330	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
E3D00_01335	ENOG4105ECY	inositol monophosphatase
E3D00_01355	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
E3D00_01375	ENOG4105C7N	Xanthine uracil vitamin C permease
E3D00_01385	ENOG4105VFE	sira family
E3D00_01390	ENOG41083BM	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
E3D00_01395	ENOG4105CTB	Polyprenyl synthetase
E3D00_01400	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
E3D00_01405	ENOG4105DX0	Hemolysin A
E3D00_01415	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
E3D00_01420	ENOG4105CDH	Citrulline--aspartate ligase
E3D00_01425	ENOG4108V1T	peptidylprolyl cis-trans isomerase
E3D00_01430	ENOG4107T8J	thymidine kinase
E3D00_01440	ENOG4105C31	Tryptophanyl-tRNA synthetase
E3D00_01445	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E3D00_01450	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
E3D00_01455	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
E3D00_01460	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
E3D00_01465	ENOG41082BR	50S ribosomal protein L35
E3D00_01470	ENOG4105DZG	Dehydrogenase
E3D00_01475	ENOG4107SZR	mannose-6-phosphate isomerase
E3D00_01480	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
E3D00_01495	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
E3D00_01500	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
E3D00_01505	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
E3D00_01530	ENOG4105CAK	Cell division ATP-binding protein ftsE
E3D00_01545	ENOG4105E9Q	Acyl-transferase
E3D00_01555	ENOG4105C4M	(Ubiquinol oxidase) subunit I
E3D00_01560	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
E3D00_01570	ENOG4108JMX	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
E3D00_01580	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
E3D00_01585	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
E3D00_01590	ENOG4105DKQ	ROK family
E3D00_01595	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E3D00_01625	ENOG4105CV8	reductase
E3D00_01635	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
E3D00_01640	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
E3D00_01645	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E3D00_01665	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
E3D00_01670	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
E3D00_01675	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
E3D00_01680	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E3D00_01685	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
E3D00_01690	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
E3D00_01695	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
E3D00_01700	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
E3D00_01705	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
E3D00_01710	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E3D00_01715	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
E3D00_01730	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
E3D00_01735	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
E3D00_01740	ENOG4105VMP	Transcriptional regulator
E3D00_01745	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
E3D00_01750	ENOG4105C7B	Threonine dehydratase
E3D00_01760	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
E3D00_01765	ENOG4105E0X	reductase
E3D00_01775	ENOG4105CN1	protease
E3D00_01785	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
E3D00_01790	ENOG4105BZ1	(ABC) transporter
E3D00_01795	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
E3D00_01805	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
E3D00_01830	ENOG4105CEC	DNA methylase N-4 N-6
E3D00_01850	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
E3D00_01855	ENOG4105BZS	acriflavin resistance protein
E3D00_01865	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
E3D00_01875	ENOG4105IE8	Alpha-ketoglutarate permease
E3D00_01880	ENOG4108ZT0	50S ribosomal protein l17
E3D00_01885	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E3D00_01890	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
E3D00_01895	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E3D00_01900	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
E3D00_01910	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
E3D00_01915	ENOG4105VPB	50S ribosomal protein L30
E3D00_01920	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
E3D00_01925	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
E3D00_01930	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
E3D00_01935	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
E3D00_01940	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
E3D00_01945	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E3D00_01950	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
E3D00_01955	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
E3D00_01960	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
E3D00_01970	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
E3D00_01975	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
E3D00_01980	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
E3D00_01985	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
E3D00_01990	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E3D00_01995	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
E3D00_02000	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
E3D00_02005	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
E3D00_02010	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
E3D00_02015	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
E3D00_02020	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
E3D00_02025	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
E3D00_02030	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E3D00_02035	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E3D00_02040	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
E3D00_02045	ENOG4108VZM	50s ribosomal protein L10
E3D00_02050	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
E3D00_02055	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
E3D00_02060	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
E3D00_02075	ENOG41062D9	Histidine kinase
E3D00_02080	ENOG4105ETX	regulatoR
E3D00_02085	ENOG4107QSV	RmuC domain protein
E3D00_02095	ENOG4105CBX	hi0933 family
E3D00_02105	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
E3D00_02110	ENOG4107QMS	site-determining protein
E3D00_02115	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
E3D00_02140	ENOG4105C8T	Leucyl-tRNA synthetase
E3D00_02145	ENOG4105TXM	Domain of unknown function (DUF3576)
E3D00_02200	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
E3D00_02205	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
E3D00_02210	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
E3D00_02215	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
E3D00_02225	ENOG4105C2N	RNA methyltransferase TrmH family group 3
E3D00_02235	ENOG4107R4J	Chloride channel
E3D00_02245	ENOG4105DZG	Dehydrogenase
E3D00_02250	ENOG4107SWE	Methyltransferase
E3D00_02255	ENOG4108YYH	Nadph-dependent fmn reductase
E3D00_02260	ENOG4108K3A	Glutathione S-transferase
E3D00_02265	ENOG4105BZA	Phosphoglycerate kinase
E3D00_02285	ENOG4105M0C	cytoplasmic protein
E3D00_02290	ENOG4105C85	amino acid
E3D00_02300	ENOG4105KUZ	arsenate reductase
E3D00_02305	ENOG4108SUT	Major Facilitator Superfamily
E3D00_02310	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
E3D00_02315	ENOG4105DFA	alanine racemase domain protein
E3D00_02320	ENOG4105DFH	Transport of potassium into the cell (By similarity)
E3D00_02325	ENOG4105CSA	Coproporphyrinogen iii oxidase
E3D00_02345	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
E3D00_02350	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
E3D00_02355	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
E3D00_02360	ENOG4107ZGG	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
E3D00_02365	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
E3D00_02380	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
E3D00_02390	ENOG4106JDQ	ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB
E3D00_02400	ENOG4105E5Q	amino acid AbC transporter
E3D00_02410	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
E3D00_02415	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
E3D00_02420	ENOG4108UM1	dedA family
E3D00_02425	ENOG4105E4C	Lytic transglycosylase catalytic
E3D00_02440	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
E3D00_02455	ENOG4105DMF	Dehydrogenase
E3D00_02460	ENOG4105EUJ	GTP cyclohydrolase i
E3D00_02470	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
E3D00_02475	ENOG4107RJX	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
E3D00_02490	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3D00_02495	ENOG4105EEI	dihydropteroate synthase
E3D00_02505	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
E3D00_02510	ENOG4105CN7	Flagellar biosynthetic protein FliP
E3D00_02520	ENOG4105SFI	flagellar basal-body rod protein
E3D00_02525	ENOG4108ZC9	flagellar basal-body rod protein flgc
E3D00_02530	ENOG4105X50	flagellar hook-basal body complex protein fliE
E3D00_02535	ENOG4105VS8	Flagellar biosynthetic protein fliq
E3D00_02545	ENOG4105D00	flagellar biosynthetic protein flhB
E3D00_02550	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
E3D00_02555	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
E3D00_02565	ENOG4108S10	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
E3D00_02575	ENOG4105CHM	Aminotransferase
E3D00_02580	ENOG4105D6E	homoserine dehydrogenase
E3D00_02585	ENOG4105CBT	Fructose-1,6-bisphosphatase
E3D00_02590	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
E3D00_02625	ENOG4105C7K	acetolactate synthase
E3D00_02630	ENOG4108N2Y	auxin Efflux
E3D00_02640	ENOG4108FN7	Aldo keto reductase
E3D00_02645	ENOG4105E2K	Glycosyl transferase (Group 1
E3D00_02655	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
E3D00_02680	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
E3D00_02685	ENOG4105E0F	Histidine kinase
E3D00_02690	ENOG4105P0B	pseudoazurin
E3D00_02695	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
E3D00_02720	ENOG4107E2E	PKHD-type hydroxylase
E3D00_02750	ENOG4105E2D	ec 3.2.1.52
E3D00_02755	ENOG4105S10	periplasmic binding protein
E3D00_02760	ENOG4105E0A	ABC, transporter
E3D00_02765	ENOG4105EHG	Permease protein
E3D00_02770	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
E3D00_02820	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
E3D00_02825	ENOG4105CAT	Cytidine monophosphate kinase
E3D00_02830	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
E3D00_02845	ENOG4105CHR	reductase
E3D00_02850	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
E3D00_02855	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
E3D00_02860	ENOG4107QMP	dna polymerase iii subunits gamma and tau
E3D00_02875	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
E3D00_02885	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
E3D00_02900	ENOG41090U3	tautomerase
E3D00_02935	ENOG4105C6X	Major Facilitator
E3D00_02945	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3D00_02950	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
E3D00_02970	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
E3D00_02985	ENOG4105D4P	Coproporphyrinogen iii oxidase
E3D00_02990	ENOG410901P	UPF0249 protein
E3D00_03015	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
E3D00_03025	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
E3D00_03030	ENOG4105K63	Thioredoxin
E3D00_03035	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
E3D00_03045	ENOG4108E87	P-loop hydrolase UPF0079
E3D00_03060	ENOG4105CAY	ferredoxin--nadp reductase
E3D00_03065	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
E3D00_03070	ENOG4105CPQ	Dehydrogenase
E3D00_03085	ENOG4105CI3	gtp-binding protein typa
E3D00_03090	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
E3D00_03095	ENOG4108AQF	aminoglycoside N(3)-acetyltransferase
E3D00_03125	ENOG4105CV8	reductase
E3D00_03150	ENOG4105D8X	mechanosensitive ion channel
E3D00_03160	ENOG4108IU3	tonb-dependent siderophore receptor
E3D00_03175	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
E3D00_03180	ENOG4108I0Z	Aconitate hydratase
E3D00_03185	ENOG4108JU3	Alkyl hydroperoxide reductase
E3D00_03190	ENOG4105D3R	alkyl hydroperoxide reductase
E3D00_03210	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
E3D00_03225	ENOG4105C59	p-type ATPase
E3D00_03230	ENOG4105E3B	Multicopper oxidase
E3D00_03245	ENOG4105CE1	Ferrous iron transport protein b
E3D00_03255	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
E3D00_03290	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
E3D00_03295	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
E3D00_03300	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
E3D00_03305	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
E3D00_03310	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E3D00_03325	ENOG410683Z	Preprotein translocase SecE subunit
E3D00_03340	ENOG4105DY2	Paraquat-inducible protein b
E3D00_03345	ENOG4105F1S	paraquat-inducible protein a
E3D00_03355	ENOG4105CE4	GlcNAc 6-P deacetylase
E3D00_03365	ENOG4105DQ4	alcohol dehydrogenase
E3D00_03375	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
E3D00_03415	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
E3D00_03420	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
E3D00_03425	ENOG4105D8X	mechanosensitive ion channel
E3D00_03435	ENOG4108JJA	ABC, transporter
E3D00_03450	ENOG41083AI	transcriptional regulator), MarR family
E3D00_03460	ENOG4108JJ7	ABC transporter
E3D00_03465	ENOG4105CSM	endonuclease III
E3D00_03480	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
E3D00_03495	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
E3D00_03500	ENOG4105CXT	aspartate transcarbamylase
E3D00_03505	ENOG4105CD3	dihydroorotase
E3D00_03510	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
E3D00_03515	ENOG4105C79	DNA protecting protein DprA
E3D00_03525	ENOG4105CN1	protease
E3D00_03550	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E3D00_03560	ENOG4105C85	amino acid
E3D00_03565	ENOG4105E2B	Taurine dioxygenase
E3D00_03590	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
E3D00_03600	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
E3D00_03605	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
E3D00_03620	ENOG4105DTN	riboflavin biosynthesis protein ribF
E3D00_03625	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
E3D00_03630	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
E3D00_03635	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
E3D00_03645	ENOG4105E2X	shikimate dehydrogenase
E3D00_03685	ENOG4107UQD	Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity)
E3D00_03690	ENOG4105C8Y	Acetylornithine aminotransferase
E3D00_03695	ENOG4105DBV	ornithine carbamoyltransferase
E3D00_03700	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
E3D00_03855	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
E3D00_03860	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
E3D00_03870	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
E3D00_03875	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
E3D00_03880	ENOG4107QUT	magnesium and cobalt transport protein CorA
E3D00_03890	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
E3D00_03900	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
E3D00_03905	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
E3D00_03915	ENOG4108UQY	Iron-storage protein
E3D00_03925	ENOG4105C5I	Dehydrogenase
E3D00_03940	ENOG4108UUM	single-stranded DNA-binding protein
E3D00_03945	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
E3D00_03950	ENOG4105DQ4	alcohol dehydrogenase
E3D00_03955	ENOG4105C72	UPF0176 protein
E3D00_03970	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
E3D00_03995	ENOG4105C2C	drug resistance transporter, Bcr CflA
E3D00_04000	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
E3D00_04010	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
E3D00_04015	ENOG4107QNK	)-transporter
E3D00_04030	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
E3D00_04045	ENOG4105DHJ	ABC, transporter
E3D00_04115	ENOG4105XZC	flagellar basal body P-ring biosynthesis protein FlgA
E3D00_04120	ENOG4105CGA	flagellar basal-body rod protein FlgG
E3D00_04125	ENOG4105KTQ	flagellar basal-body rod protein
E3D00_04135	ENOG4105D01	(LipO)protein
E3D00_04140	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
E3D00_04145	ENOG4108UMI	ABC transporter, permease
E3D00_04155	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
E3D00_04175	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
E3D00_04185	ENOG4105CKK	Glycosyl transferase, family 2
E3D00_04205	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
E3D00_04210	ENOG4105EIF	outer membrane protein W
E3D00_04215	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
E3D00_04230	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
E3D00_04235	ENOG4108R6K	riboflavin synthase, subunit alpha
E3D00_04240	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
E3D00_04245	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
E3D00_04250	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
E3D00_04255	ENOG4105Z85	coenzyme PQQ synthesis
E3D00_04260	ENOG41086XE	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity)
E3D00_04265	ENOG4105JIE	May be involved in the transport of PQQ or its precursor to the periplasm (By similarity)
E3D00_04275	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
E3D00_04280	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
E3D00_04285	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
E3D00_04290	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
E3D00_04295	ENOG4108Z03	MAF-like protein
E3D00_04315	ENOG4105CPC	Aldo Keto reductase
E3D00_04355	ENOG4105BZE	flagellar hook protein, FlgE
E3D00_04370	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
E3D00_04375	ENOG4105DHU	Bile acid
E3D00_04380	ENOG4108HKT	sucrose-6-phosphate hydrolase
E3D00_04395	ENOG4107T5V	SNARE associated Golgi
E3D00_04400	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
E3D00_04405	ENOG4108YXA	Membrane
E3D00_04410	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
E3D00_04415	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
E3D00_04420	ENOG4108UHJ	MAF-like protein
E3D00_04430	ENOG4108Z66	YbaK ebsC protein
E3D00_04445	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
E3D00_04450	ENOG4105CC5	ABC transporter
E3D00_04465	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
E3D00_04475	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
E3D00_04490	ENOG4105FA0	parb-like partition protein
E3D00_04495	ENOG4107QJE	Chromosome Partitioning Protein
E3D00_04500	ENOG4107YTN	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity)
E3D00_04505	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
E3D00_04510	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
E3D00_04515	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
E3D00_04565	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
E3D00_04585	ENOG4105CEN	a g-specific adenine glycosylase
E3D00_04600	ENOG4105EAC	phosphoserine phosphatase
E3D00_04605	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
E3D00_04610	ENOG4105C7K	acetolactate synthase
E3D00_04615	ENOG4108ZP8	Acetolactate synthase small subunit
E3D00_04620	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
E3D00_04625	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
E3D00_04630	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
E3D00_04640	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
E3D00_04645	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
E3D00_04650	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E3D00_04660	ENOG4105EN6	Membrane
E3D00_04665	ENOG4105C5F	glutamine synthetase
E3D00_04675	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
E3D00_04695	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
E3D00_04700	ENOG4105CKK	Glycosyl transferase, family 2
E3D00_04705	ENOG4108733	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E3D00_04710	ENOG4108VHN	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E3D00_04720	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
E3D00_04730	ENOG4107RTZ	reductase
E3D00_04755	ENOG41067VU	UPF0391 membrane protein
E3D00_04765	ENOG4107SJB	teichoic acid biosynthesis
E3D00_04780	ENOG4106IQQ	
E3D00_04795	ENOG4105II7	pyrroline-5-carboxylate reductase
E3D00_04805	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
E3D00_04810	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
E3D00_04815	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
E3D00_04820	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
E3D00_04825	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
E3D00_04830	ENOG4105C3G	gtp-binding protein
E3D00_04835	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
E3D00_04840	ENOG4107WK2	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
E3D00_04850	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
E3D00_04865	ENOG4105C5X	domain protein
E3D00_04920	ENOG4105CVR	type I restriction-modification system
E3D00_04930	ENOG41060A7	DNA polymerase beta domain protein region
E3D00_04935	ENOG4105EKX	Restriction modification system DNA (Specificity
E3D00_04940	ENOG4105DZR	Type I site-specific deoxyribonuclease
E3D00_04955	ENOG4105CMR	udp-glucose 4-epimerase
E3D00_04970	ENOG4105DN3	alpha-2-macroglobulin domain protein
E3D00_04975	ENOG4108JQB	penicillin-binding protein 1C
E3D00_04990	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
E3D00_04995	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
E3D00_05000	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E3D00_05015	ENOG4105DS1	cytochrome b561
E3D00_05020	ENOG4108YYC	ycei family
E3D00_05025	ENOG4105HEI	LysR family (Transcriptional regulator
E3D00_05030	ENOG4105C2I	pirin domain protein
E3D00_05050	ENOG4105DAY	polysaccharide export protein
E3D00_05070	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
E3D00_05085	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
E3D00_05095	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
E3D00_05105	ENOG4105C10	Electron transfer flavoprotein
E3D00_05110	ENOG4105BZJ	Electron transfer flavoprotein
E3D00_05115	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
E3D00_05120	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
E3D00_05125	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
E3D00_05130	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
E3D00_05135	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
E3D00_05140	ENOG4105CFG	Acts as a chaperone (By similarity)
E3D00_05175	ENOG4105DHP	deoxycytidine triphosphate deaminase
E3D00_05180	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
E3D00_05200	ENOG4105CXG	d-lactate dehydrogenase
E3D00_05215	ENOG4108URH	decarboxylase
E3D00_05220	ENOG4105F9N	Major Facilitator Superfamily
E3D00_05225	ENOG4107SFH	ImpB mucB samB family
E3D00_05245	ENOG4105C2C	drug resistance transporter, Bcr CflA
E3D00_05255	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
E3D00_05260	ENOG4108DBC	nitroreductase
E3D00_05265	ENOG4105CQ7	ATP-dependent helicase
E3D00_05270	ENOG4108SB3	DoxX Family
E3D00_05280	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E3D00_05285	ENOG4105E0F	Histidine kinase
E3D00_05300	ENOG4105C26	Dehydrogenase
E3D00_05305	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
E3D00_05310	ENOG4105C22	threonyL-tRNA synthetase
E3D00_05325	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E3D00_05330	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
E3D00_05335	ENOG4105EB3	Histidine kinase
E3D00_05340	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
E3D00_05345	ENOG4105MYN	Zinc uptake regulation protein
E3D00_05355	ENOG4107QNK	)-transporter
E3D00_05360	ENOG4105C34	Pseudouridine synthase
E3D00_05365	ENOG4105CNU	cell division protein FtsK
E3D00_05370	ENOG4106H78	methyltransferase
E3D00_05375	ENOG4105FE9	pseudouridine synthase
E3D00_05380	ENOG4108Z86	Glutamine amidotransferase
E3D00_05385	ENOG4108Z6B	deaminase
E3D00_05405	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
E3D00_05420	ENOG4107W75	Flagellin
E3D00_05430	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
E3D00_05440	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
E3D00_05450	ENOG4105E0F	Histidine kinase
E3D00_05460	ENOG4108RDT	NADH dehydrogenase NAD(P)H nitroreductase)
E3D00_05485	ENOG41090R7	Ferric uptake
E3D00_05495	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
E3D00_05500	ENOG4108WRK	Transcriptional regulator
E3D00_05515	ENOG4105W49	UPF0434 protein
E3D00_05520	ENOG4105K63	Thioredoxin
E3D00_05540	ENOG4105F0N	pyrophosphate phospho-hydrolase
E3D00_05550	ENOG4105C5H	ABC transporter
E3D00_05570	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
E3D00_05575	ENOG4105D7W	serine acetyltransferase
E3D00_05580	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
E3D00_05595	ENOG4105BZU	Histidine kinase
E3D00_05610	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E3D00_05615	ENOG4105C25	Primosomal protein n'
E3D00_05650	ENOG4105Y49	secretion protein, HlyD family
E3D00_05665	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
E3D00_05670	ENOG4105DJ9	glucan biosynthesis protein
E3D00_05675	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
E3D00_05680	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
E3D00_05690	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
E3D00_05705	ENOG4105CNG	UPF0061 protein
E3D00_05715	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
E3D00_05750	ENOG4105C8U	phosphate abc transporter
E3D00_05755	ENOG4105E2Z	phosphate ABC transporter (Permease
E3D00_05760	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
E3D00_05765	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
E3D00_05770	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E3D00_05780	ENOG41074H6	response regulator
E3D00_05785	ENOG4105BZU	Histidine kinase
E3D00_05790	ENOG4105CQZ	Histidine kinase
E3D00_05795	ENOG4105C85	amino acid
E3D00_05830	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
E3D00_05835	ENOG4105BZS	acriflavin resistance protein
E3D00_05840	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
E3D00_05870	ENOG4107QKS	N-acylglucosamine 2-epimerase
E3D00_05875	ENOG4105DJV	ribulose-phosphate 3-epimerase
E3D00_05885	ENOG4107RJ7	Glycosyl transferase (Group 1
E3D00_05895	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
E3D00_05900	ENOG4105DHZ	alpha beta
E3D00_05910	ENOG4105C3J	Cysteine desulfurase
E3D00_05920	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
E3D00_05935	ENOG410829K	Lysine exporter protein (Lyse ygga)
E3D00_05940	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
E3D00_05955	ENOG4108ZZ3	UPF0260 protein
E3D00_05990	ENOG4105Y49	secretion protein, HlyD family
E3D00_05995	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
E3D00_06000	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
E3D00_06010	ENOG4105DUX	Transporter
E3D00_06055	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
E3D00_06070	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
E3D00_06080	ENOG4108MI0	Resistance protein
E3D00_06085	ENOG4105J12	Multidrug resistance protein mdtN
E3D00_06120	ENOG4105ENX	hydrolase
E3D00_06125	ENOG4105ENX	hydrolase
E3D00_06130	ENOG4105EQ2	LysR family Transcriptional regulator
E3D00_06165	ENOG4108X1T	PAAR repeat-containing protein
E3D00_06185	ENOG4105VGJ	Virulence-associated protein
E3D00_06190	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
E3D00_06205	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E3D00_06215	ENOG4105D1F	ATP-binding protein
E3D00_06230	ENOG4105DEI	Mannitol dehydrogenase
E3D00_06235	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
E3D00_06245	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
E3D00_06255	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
E3D00_06260	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
E3D00_06265	ENOG4105DXN	mazG family
E3D00_06270	ENOG4107SQ0	N-acetyl-gamma-glutamyl-phosphate reductase
E3D00_06285	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
E3D00_06290	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
E3D00_06295	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
E3D00_06300	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
E3D00_06305	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
E3D00_06310	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
E3D00_06315	ENOG4105C1J	atp-dependent rna helicase
E3D00_06320	ENOG4105CSR	polyphosphate kinase 2
E3D00_06325	ENOG4105EMU	Dehydrogenase
E3D00_06330	ENOG4108UJU	UPF0301 protein
E3D00_06335	ENOG4105CPC	Aldo Keto reductase
E3D00_06340	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E3D00_06370	ENOG4105E1F	short-chain dehydrogenase reductase
E3D00_06375	ENOG4108MIW	Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions
E3D00_06380	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
E3D00_06435	ENOG4105CKI	cobalamin synthesis protein
E3D00_06480	ENOG4108TEB	UPF0114 protein
E3D00_06485	ENOG4105DZ0	fad dependent oxidoreductase
E3D00_06500	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
E3D00_06510	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
E3D00_06525	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
E3D00_06530	ENOG4105BZU	Histidine kinase
E3D00_06540	ENOG4105C9Q	fumarate hydratase class II
E3D00_06565	ENOG4105KWW	Biogenesis protein
E3D00_06570	ENOG4107QX9	Thiol disulfide interChange protein
E3D00_06575	ENOG4105DA4	cytochrome c-type biogenesis protein
E3D00_06580	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
E3D00_06590	ENOG41060IM	Heme exporter protein
E3D00_06610	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
E3D00_06630	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E3D00_06640	ENOG4105D1H	recombination factor protein RarA
E3D00_06645	ENOG4105EI2	Pseudouridine synthase
E3D00_06660	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
E3D00_06665	ENOG4105NWN	ApaG protein
E3D00_06685	ENOG4105CEP	NADH dehydrogenase
E3D00_06690	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
E3D00_06695	ENOG4107TF3	peptidylprolyl cis-trans isomerase
E3D00_06700	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
E3D00_06705	ENOG4105CDY	transcriptional regulatory protein
E3D00_06710	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
E3D00_06715	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
E3D00_06720	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
E3D00_06725	ENOG4107YD3	Thioesterase
E3D00_06730	ENOG4105E02	MotA TolQ exbB proton channel
E3D00_06735	ENOG4108ZZF	transport protein (ExbD)
E3D00_06745	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
E3D00_06750	ENOG4105KCK	Peptidoglycan-associated lipoprotein
E3D00_06760	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
E3D00_06770	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
E3D00_06775	ENOG4105DWF	phosphomethylpyrimidine kinase
E3D00_06780	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
E3D00_06785	ENOG4108JIR	Flagellum-specific ATP synthase
E3D00_06800	ENOG4105C88	aminopeptidase
E3D00_06815	ENOG4105CIH	Imidazole acetol-phosphate transaminase
E3D00_06835	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
E3D00_06840	ENOG4108J5G	6-phosphogluconate dehydrogenase
E3D00_06845	ENOG4108K4B	hydrolase
E3D00_06850	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
E3D00_06855	ENOG4105E66	phosphoriboisomerase A
E3D00_06860	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
E3D00_06865	ENOG4108UPT	UPF0178 protein
E3D00_06870	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E3D00_06875	ENOG4105EGS	Mechanosensitive ion channel
E3D00_06880	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
E3D00_06890	ENOG4105EEQ	Na H antiporter
E3D00_06895	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
E3D00_06900	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
E3D00_06925	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
E3D00_06930	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
E3D00_06935	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
E3D00_06955	ENOG4105CHH	sulfate transporter
E3D00_06980	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
E3D00_06985	ENOG4108UJD	30S ribosomal protein S9
E3D00_06990	ENOG4105CM2	brancheD-chain amino acid aminotransferase
E3D00_07000	ENOG410801B	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
E3D00_07005	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
E3D00_07015	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
E3D00_07020	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
E3D00_07045	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
E3D00_07050	ENOG4107U9T	Pfam:Ribonuclease_BN
E3D00_07060	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
E3D00_07065	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
E3D00_07070	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
E3D00_07090	ENOG4107K5X	Membrane-bound metal-dependent hydrolase
E3D00_07095	ENOG4105DC1	bifunctional purine biosynthesis protein purh
E3D00_07110	ENOG4105W00	Flagellar hook capping protein
E3D00_07115	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
E3D00_07120	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
E3D00_07130	ENOG4105DD5	Flagellar motor switch protein
E3D00_07135	ENOG4105D7B	Flagellar biosynthesis protein flha
E3D00_07140	ENOG4105FZW	flagellar biosynthesis regulator FlhF
E3D00_07150	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
E3D00_07155	ENOG4105KJF	protein tyrosine phosphatase
E3D00_07160	ENOG4108N2Y	auxin Efflux
E3D00_07170	ENOG4107R1I	NAD-dependent malic enzyme
E3D00_07175	ENOG4105CH6	catalase
E3D00_07180	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E3D00_07195	ENOG4105YVS	arsR family transcriptional regulator
E3D00_07200	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
E3D00_07530	ENOG4105Y2X	UPF0335 protein
E3D00_07645	ENOG4105E8V	Alpha Beta Hydrolase Fold protein
E3D00_07650	ENOG4105C2M	dna polymerase I
E3D00_07660	ENOG4105DEF	Extracellular solute-binding protein, family 5
E3D00_07670	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
E3D00_07680	ENOG4105C03	ribonuclease
E3D00_07685	ENOG4108KNB	n-acetylmuramoyl-l-alanine amidase
E3D00_07690	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
E3D00_07695	ENOG4107TSN	permease
E3D00_07725	ENOG4105CJN	penicillin-binding protein
E3D00_07730	ENOG4105CNI	cell division protein FtsW
E3D00_07740	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
E3D00_07745	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
E3D00_07760	ENOG4105C9M	aspartyl-trna synthetase
E3D00_07775	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
E3D00_07780	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
E3D00_07785	ENOG4105C75	arginyL-tRNA synthetase
E3D00_07795	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
E3D00_07800	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
E3D00_07810	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
E3D00_07815	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
E3D00_07830	ENOG4105DP0	ferredoxin-NADP reductase
E3D00_07855	ENOG4105CF1	Alkylated DNA repair protein
E3D00_07860	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
E3D00_07875	ENOG4106KE4	Dehydrogenase
E3D00_07880	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
E3D00_07895	ENOG4105C8N	cysteinyl-tRNA synthetase
E3D00_07900	ENOG4107QI1	Mate efflux family protein
E3D00_07910	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
E3D00_07915	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
E3D00_07935	ENOG4107B2H	carbonic anhydrase
E3D00_07940	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
E3D00_07955	ENOG4105D49	3-dehydroquinate synthase
E3D00_07965	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E3D00_07970	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
E3D00_07985	ENOG4105M6F	mutator MutT protein
E3D00_08000	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
E3D00_08010	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
E3D00_08015	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
E3D00_08030	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
E3D00_08035	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
E3D00_08040	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
E3D00_08045	ENOG4105C3F	Signal peptidase i
E3D00_08050	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
E3D00_08055	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
E3D00_08060	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
E3D00_08065	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
E3D00_08070	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
E3D00_08075	ENOG4105KNE	Phosphatidate cytidylyltransferase
E3D00_08080	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
E3D00_08085	ENOG4105DZP	Membrane-associated zinc metalloprotease
E3D00_08090	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3D00_08100	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E3D00_08105	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
E3D00_08110	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E3D00_08115	ENOG4105GYT	Protein of unknown function (DUF1009)
E3D00_08130	ENOG4105VG0	50S ribosomal protein l34
E3D00_08135	ENOG41087PG	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
E3D00_08140	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
E3D00_08145	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
E3D00_08150	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
E3D00_08155	ENOG4105CAS	nag kinase
E3D00_08160	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
E3D00_08165	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
E3D00_08175	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
E3D00_08180	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
E3D00_08185	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
E3D00_08195	ENOG4108ZNX	Heat shock protein
E3D00_08205	ENOG4105M4H	endoribonuclease L-psp
E3D00_08210	ENOG4108IUZ	ABC transporter
E3D00_08225	ENOG4105C2X	Arabinose 5-phosphate isomerase
E3D00_08240	ENOG4108RCM	Nitroreductase
E3D00_08260	ENOG4105DPN	Oligoendopeptidase f
E3D00_08275	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
E3D00_08285	ENOG4108RRZ	Transcription elongation factor GreB
E3D00_08290	ENOG4105D7Z	glutathione synthase
E3D00_08295	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
E3D00_08300	ENOG4105BZ9	Cytochrome C oxidase, subunit I
E3D00_08305	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
E3D00_08315	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
E3D00_08320	ENOG4105C1V	Peptidase, M16
E3D00_08325	ENOG4105D98	threonine synthase
E3D00_08345	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
E3D00_08350	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
E3D00_08355	ENOG4105CJR	Integral membrane protein (MviN
E3D00_08360	ENOG4108V06	Glutathione peroxidase
E3D00_08365	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
E3D00_08370	ENOG4105D6S	protein involved in catabolism of external DNA
E3D00_08375	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E3D00_08380	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
E3D00_08390	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
E3D00_08410	ENOG4105CA0	peroxidase
E3D00_08425	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
E3D00_08430	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
E3D00_08435	ENOG4105CDZ	Carboxymethylenebutenolidase (EC 3.1.1.45)
E3D00_08445	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
E3D00_08450	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
E3D00_08460	ENOG4105DVT	helicase
E3D00_08465	ENOG4105DK7	lysyl-tRNA synthetase
E3D00_08475	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
E3D00_08480	ENOG4108RG0	uracil-dna glycosylase
E3D00_08490	ENOG4105HFZ	Membrane
E3D00_08505	ENOG4105CCU	oxidase (Subunit III)
E3D00_08510	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
E3D00_08520	ENOG4105EI2	Pseudouridine synthase
E3D00_08530	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
E3D00_08550	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
E3D00_08565	ENOG4105C5H	ABC transporter
E3D00_08570	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
E3D00_08580	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
E3D00_08595	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
E3D00_08600	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
E3D00_08610	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
E3D00_08625	ENOG4105F27	Major Facilitator
E3D00_08670	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E3D00_08705	ENOG4105CH7	arginosuccinase
E3D00_08710	ENOG4107ZT5	Thiol disulfide interchange protein
E3D00_08720	ENOG4105E2X	shikimate dehydrogenase
E3D00_08725	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
E3D00_08730	ENOG4107RZZ	dna polymerase iii epsilon subunit
E3D00_08740	ENOG4107RJ7	Glycosyl transferase (Group 1
E3D00_08745	ENOG4105CAQ	asparagine synthetase
E3D00_08750	ENOG4105CD3	dihydroorotase
E3D00_08770	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
E3D00_08775	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
E3D00_08780	ENOG4107QNK	)-transporter
E3D00_08785	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
E3D00_08805	ENOG4105D1K	glutamate--cysteine ligase
E3D00_08815	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
E3D00_08835	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
E3D00_08840	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
E3D00_08855	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
E3D00_08860	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
E3D00_08865	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
E3D00_08870	ENOG4108Z9K	Osmotically inducible protein
E3D00_08875	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
E3D00_08880	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
E3D00_08890	ENOG4105EAH	synthase
E3D00_08895	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
E3D00_08900	ENOG4107SW0	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
E3D00_08915	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
E3D00_08925	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
E3D00_08930	ENOG4108R9S	DSBA oxidoreductase
E3D00_08935	ENOG4108R9S	DSBA oxidoreductase
E3D00_08940	ENOG4107RCQ	(CBS) domain
E3D00_08945	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
E3D00_08950	ENOG4105C9A	Phoh family
E3D00_08955	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
E3D00_08965	ENOG4105CFU	surface antigen
E3D00_08975	ENOG4105RQ9	TPR repeat-containing protein
E3D00_08980	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
E3D00_08985	ENOG4108VJ1	Transcriptional regulator (CarD family
E3D00_08990	ENOG4105FFC	UPF0187 protein
E3D00_08995	ENOG4107QPD	alcohol dehydrogenase
E3D00_09000	ENOG4105C4W	S-formylglutathione hydrolase
E3D00_09005	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
E3D00_09010	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
E3D00_09025	ENOG4105FDK	ABC transporter
E3D00_09040	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
E3D00_09055	ENOG4105C9K	Endothelin-converting enzyme 1
E3D00_09065	ENOG4106B0W	Curli production assembly transport component CsgG
E3D00_09075	ENOG4107Y60	(LipO)protein
E3D00_09090	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
E3D00_09100	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
E3D00_09105	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
E3D00_09110	ENOG4105HHA	aminodeoxychorismate lyase
E3D00_09120	ENOG4105ECY	inositol monophosphatase
E3D00_09125	ENOG4106Z5D	Glycoside Hydrolase Family 43
E3D00_09130	ENOG4107T8Q	Glycosyl transferase (Group 1
E3D00_09155	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
E3D00_09170	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
E3D00_09175	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
E3D00_09185	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
E3D00_09190	ENOG4105CSV	Glutaminase
E3D00_09195	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
E3D00_09205	ENOG4105EMU	Dehydrogenase
E3D00_09215	ENOG4105C3R	Methionine synthase
E3D00_09265	ENOG4105EZR	dyp-type peroxidase family protein
E3D00_09270	ENOG4107Z1W	Fructose transport system kinase
E3D00_09275	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
E3D00_09280	ENOG4108SB3	DoxX Family
E3D00_09285	ENOG4105C26	Dehydrogenase
E3D00_09290	ENOG4105EW9	transcriptional regulator AsnC family
E3D00_09295	ENOG4107QK9	Beta-lactamase
E3D00_09305	ENOG4105WYW	fructose-bisphosphate aldolase
E3D00_09310	ENOG4107XMU	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E3D00_09320	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
E3D00_09335	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
E3D00_09340	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
E3D00_09385	ENOG4105QUC	reductase
E3D00_09405	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
E3D00_09410	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
E3D00_09415	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
E3D00_09420	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
E3D00_09425	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
E3D00_09430	ENOG4105EFT	decarboxylase
E3D00_09440	ENOG4108ESX	Receptor
E3D00_09455	ENOG4105EHG	Permease protein
E3D00_09460	ENOG4105CHR	reductase
E3D00_09465	ENOG4105C6Z	Gluconate
E3D00_09470	ENOG4105C2C	drug resistance transporter, Bcr CflA
E3D00_09500	ENOG4108IYU	L-aspartate oxidase
E3D00_09505	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
E3D00_09510	ENOG4107QXV	Phosphate transporter
E3D00_09550	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
E3D00_09555	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
E3D00_09585	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
E3D00_09590	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
E3D00_09610	ENOG4105D06	uba thif-type nad fad binding protein
E3D00_09625	ENOG4105CA9	Pyruvate kinase
E3D00_09630	ENOG4105EVN	Prephenate dehydrogenase
E3D00_09645	ENOG41076QQ	Glycosyl transferase, family 2
E3D00_09650	ENOG4105FBD	synthase
E3D00_09655	ENOG4105FE1	phytoene synthase
E3D00_09660	ENOG4107S11	squalene-associated FAD-dependent desaturase
E3D00_09665	ENOG4105EWU	Squalene--hopene cyclase
E3D00_09675	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
E3D00_09695	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
E3D00_09715	ENOG4105CGK	Exodeoxyribonuclease III
E3D00_09720	ENOG4108IGT	Dipeptidase
E3D00_09725	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
E3D00_09740	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
E3D00_09745	ENOG4105W0E	50S ribosomal protein L33
E3D00_09755	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
E3D00_09765	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
E3D00_09770	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
E3D00_09790	ENOG4105CRQ	synthase (Component I)
E3D00_09795	ENOG4105DDQ	anthranilate synthase
E3D00_09800	ENOG4107QYG	anthranilate phosphoribosyltransferase
E3D00_09805	ENOG4105DK0	Indole-3-glycerol phosphate synthase
E3D00_09810	ENOG4108JYK	Dehydrogenase
E3D00_09815	ENOG4105CPP	Dehydrogenase, E1 component
E3D00_09830	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
E3D00_09845	ENOG4105CEV	competence damage-inducible protein
E3D00_09850	ENOG4107SC1	transglycosylase
E3D00_09855	ENOG4108ZCF	integral membrane protein
E3D00_09860	ENOG4105C83	adenylosuccinate lyase
E3D00_09865	ENOG4107QPR	SAICAR synthetase
E3D00_09870	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
E3D00_09880	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
E3D00_09885	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
E3D00_09905	ENOG41082FP	UPF0102 protein
E3D00_09910	ENOG4105D52	delta-aminolevulinic acid dehydratase
E3D00_09915	ENOG4105CUB	amino acid
E3D00_09920	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
E3D00_09935	ENOG4105C1J	atp-dependent rna helicase
E3D00_09950	ENOG4105KK4	UPF0060 membrane protein
E3D00_09955	ENOG4105C3M	thioredoxin reductase
E3D00_09960	ENOG41069NU	Nitroreductase
E3D00_09965	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
E3D00_09975	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
E3D00_09985	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
E3D00_09990	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
E3D00_09995	ENOG4105K59	histidine triad (HIT) protein
E3D00_10020	ENOG4105CMG	Carbohydrate kinase
E3D00_10040	ENOG4105CAY	ferredoxin--nadp reductase
E3D00_10045	ENOG4105DJ2	Major Facilitator Superfamily
E3D00_10070	ENOG4105C2I	pirin domain protein
E3D00_10080	ENOG4105DC7	peptidase M24
E3D00_10085	ENOG4108Z7F	N-acetyltransferase
E3D00_10090	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
E3D00_10100	ENOG4105W5Q	DNA repair protein (RadC
E3D00_10105	ENOG4105W5Q	DNA repair protein (RadC
E3D00_10110	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
E3D00_10115	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
E3D00_10130	ENOG4108ZNX	Heat shock protein
E3D00_10135	ENOG41082FS	50S ribosomal protein L31
E3D00_10140	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
E3D00_10150	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
E3D00_10155	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
E3D00_10160	ENOG4105D9R	oxidoreductase
E3D00_10165	ENOG4105C5H	ABC transporter
E3D00_10170	ENOG41074H6	response regulator
E3D00_10190	ENOG4108JJ9	ABC, transporter
E3D00_10195	ENOG4108JJ8	(ABC) transporter
E3D00_10205	ENOG4105C9U	ATP-dependent DNA helicase RecQ
E3D00_10215	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
E3D00_10220	ENOG4107XZX	Involved in the transcription termination process (By similarity)
E3D00_10225	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
E3D00_10235	ENOG4105EMU	Dehydrogenase
E3D00_10260	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
E3D00_10265	ENOG4105C01	Dihydroxy-acid dehydratase
E3D00_10270	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
E3D00_10285	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
E3D00_10290	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
E3D00_10295	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
E3D00_10300	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
E3D00_10305	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
E3D00_10350	ENOG4105VGJ	Virulence-associated protein
E3D00_10355	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
E3D00_10435	ENOG4105YES	addiction module antidote protein
E3D00_10440	ENOG4105VUH	addiction module killer protein
E3D00_10450	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
E3D00_10480	ENOG4105EZN	Cobyrinic acid ac-diamide synthase