locus-tag	class	description
E3E12_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
E3E12_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
E3E12_00035	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
E3E12_00050	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
E3E12_00070	ENOG4107R5R	arsenical pump membrane protein
E3E12_00075	ENOG4108K3A	Glutathione S-transferase
E3E12_00100	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
E3E12_00180	ENOG4105HHA	aminodeoxychorismate lyase
E3E12_00185	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
E3E12_00190	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
E3E12_00200	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
E3E12_00210	ENOG4105C9K	Endothelin-converting enzyme 1
E3E12_00215	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
E3E12_00230	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
E3E12_00235	ENOG4105CY3	ABC transporter, permease
E3E12_00245	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
E3E12_00250	ENOG4105FFC	UPF0187 protein
E3E12_00255	ENOG4108VJ1	Transcriptional regulator (CarD family
E3E12_00260	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
E3E12_00265	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
E3E12_00275	ENOG4105CFU	surface antigen
E3E12_00285	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
E3E12_00290	ENOG4105C9A	Phoh family
E3E12_00295	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
E3E12_00300	ENOG4107RCQ	(CBS) domain
E3E12_00305	ENOG4107ZQN	disulfide bond
E3E12_00320	ENOG4107SW0	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
E3E12_00325	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
E3E12_00330	ENOG4105EAH	synthase
E3E12_00335	ENOG4107R25	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
E3E12_00340	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
E3E12_00345	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
E3E12_00350	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
E3E12_00355	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
E3E12_00360	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
E3E12_00365	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
E3E12_00380	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
E3E12_00390	ENOG4105D1K	glutamate--cysteine ligase
E3E12_00400	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
E3E12_00405	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
E3E12_00410	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
E3E12_00420	ENOG4105CD3	dihydroorotase
E3E12_00430	ENOG4107RZZ	dna polymerase iii epsilon subunit
E3E12_00435	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
E3E12_00440	ENOG4105E2X	shikimate dehydrogenase
E3E12_00455	ENOG4105CH7	arginosuccinase
E3E12_00470	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
E3E12_00475	ENOG4107YM4	Beta-lactamase domain-containing protein
E3E12_00480	ENOG4105F8V	Hydrolase, tatD family
E3E12_00490	ENOG4107QRG	dna polymerase iii
E3E12_00495	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
E3E12_00500	ENOG4105DZ1	carboxypeptidase
E3E12_00505	ENOG4105CVE	Lytic murein transglycosylase
E3E12_00525	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
E3E12_00530	ENOG4105CUB	amino acid
E3E12_00545	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
E3E12_00560	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
E3E12_00565	ENOG4105CUT	histidyl-tRNA synthetase
E3E12_00570	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
E3E12_00580	ENOG4105EA8	2-Nitropropane dioxygenase
E3E12_00585	ENOG4105CFH	Aspartokinase
E3E12_00590	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
E3E12_00595	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
E3E12_00605	ENOG4105VW4	glutaredoxin 3
E3E12_00630	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
E3E12_00640	ENOG4105M85	Bola protein
E3E12_00645	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
E3E12_00665	ENOG4105C0B	DNA polymerase III (alpha subunit)
E3E12_00670	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
E3E12_00680	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
E3E12_00690	ENOG4107QNB	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
E3E12_00705	ENOG4105K70	DNA-binding protein
E3E12_00715	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
E3E12_00720	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
E3E12_00725	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
E3E12_00735	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
E3E12_00745	ENOG4105C1J	atp-dependent rna helicase
E3E12_00750	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
E3E12_00755	ENOG4105VG1	fes assembly suf system protein
E3E12_00760	ENOG4105C9B	Cysteine desulfurase
E3E12_00765	ENOG4105JRK	feS assembly protein SufD
E3E12_00770	ENOG4105C3K	feS assembly ATPase SufC
E3E12_00785	ENOG4106BRA	Membrane
E3E12_00795	ENOG4107R4J	Chloride channel
E3E12_00800	ENOG4107R4J	Chloride channel
E3E12_00805	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
E3E12_00810	ENOG4105KDC	50s ribosomal protein l28
E3E12_00815	ENOG4108JJ7	ABC transporter
E3E12_00825	ENOG4105IPI	Membrane
E3E12_00840	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
E3E12_00845	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
E3E12_00850	ENOG41082R8	50S ribosomal protein l32
E3E12_00865	ENOG4105K5G	30S ribosomal protein S21
E3E12_00875	ENOG4105C3M	thioredoxin reductase
E3E12_00880	ENOG4105ETT	transcriptional Regulator, LysR family
E3E12_00890	ENOG4105DSW	Fusaric acid resistance protein
E3E12_00925	ENOG4105DFP	Integrase
E3E12_00935	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
E3E12_00940	ENOG4105K46	50S ribosomal protein l27
E3E12_00945	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E3E12_00950	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
E3E12_00955	ENOG4105Y2X	UPF0335 protein
E3E12_00960	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
E3E12_00975	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
E3E12_00990	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
E3E12_01000	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
E3E12_01005	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
E3E12_01015	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
E3E12_01020	ENOG4105DFU	Cell wall formation (By similarity)
E3E12_01025	ENOG4105D4A	Cell wall formation (By similarity)
E3E12_01030	ENOG4105CPF	Cell wall formation (By similarity)
E3E12_01035	ENOG4108UFP	Essential cell division protein (By similarity)
E3E12_01040	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
E3E12_01045	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
E3E12_01050	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E3E12_01065	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
E3E12_01070	ENOG4105C37	(CBS) domain
E3E12_01090	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
E3E12_01100	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
E3E12_01105	ENOG4105CUV	Homoserine Kinase
E3E12_01110	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
E3E12_01140	ENOG4105CHM	Aminotransferase
E3E12_01145	ENOG4105CHM	Aminotransferase
E3E12_01150	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
E3E12_01155	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
E3E12_01160	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
E3E12_01165	ENOG4105K5M	30s ribosomal protein S16
E3E12_01170	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3E12_01190	ENOG4105DZR	Type I site-specific deoxyribonuclease
E3E12_01235	ENOG4105DQQ	Major facilitator superfamily MFS_1
E3E12_01240	ENOG4105CRU	nitrate reductase, alpha subunit
E3E12_01245	ENOG4108IUE	nitrate reductase beta subunit
E3E12_01250	ENOG4108NZN	Respiratory nitrate reductase 2 delta chain
E3E12_01255	ENOG41076YT	nitrate reductase, gamma subunit
E3E12_01260	ENOG4108TKH	Nitroreductase
E3E12_01275	ENOG4105C1J	atp-dependent rna helicase
E3E12_01300	ENOG4105D48	metallophosphoesterase
E3E12_01305	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
E3E12_01330	ENOG4106HMZ	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
E3E12_01340	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
E3E12_01345	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
E3E12_01355	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
E3E12_01360	ENOG4105ECY	inositol monophosphatase
E3E12_01370	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
E3E12_01380	ENOG41083BM	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
E3E12_01385	ENOG4105CTB	Polyprenyl synthetase
E3E12_01390	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
E3E12_01395	ENOG4105DX0	Hemolysin A
E3E12_01400	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
E3E12_01410	ENOG4105CDH	Citrulline--aspartate ligase
E3E12_01415	ENOG4108V1T	peptidylprolyl cis-trans isomerase
E3E12_01420	ENOG4105C31	Tryptophanyl-tRNA synthetase
E3E12_01430	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
E3E12_01435	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E3E12_01440	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
E3E12_01445	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
E3E12_01450	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
E3E12_01455	ENOG41082BR	50S ribosomal protein L35
E3E12_01465	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
E3E12_01490	ENOG4105E9Q	Acyl-transferase
E3E12_01505	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
E3E12_01510	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
E3E12_01515	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
E3E12_01525	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
E3E12_01530	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
E3E12_01535	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E3E12_01555	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
E3E12_01560	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
E3E12_01580	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
E3E12_01590	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
E3E12_01595	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
E3E12_01600	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
E3E12_01605	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
E3E12_01610	ENOG4108IYU	L-aspartate oxidase
E3E12_01625	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E3E12_01630	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
E3E12_01640	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
E3E12_01645	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
E3E12_01650	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
E3E12_01660	ENOG4105D4P	Coproporphyrinogen iii oxidase
E3E12_01665	ENOG4105E0X	reductase
E3E12_01675	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E3E12_01685	ENOG4105DSW	Fusaric acid resistance protein
E3E12_01690	ENOG4105CN1	protease
E3E12_01695	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
E3E12_01700	ENOG4105BZ1	(ABC) transporter
E3E12_01710	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
E3E12_01735	ENOG4105C5I	Dehydrogenase
E3E12_01740	ENOG4105CEC	DNA methylase N-4 N-6
E3E12_01745	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
E3E12_01765	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
E3E12_01770	ENOG4105BZS	acriflavin resistance protein
E3E12_01780	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
E3E12_01790	ENOG4108ZT0	50S ribosomal protein l17
E3E12_01795	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E3E12_01800	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
E3E12_01805	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E3E12_01810	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
E3E12_01820	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
E3E12_01825	ENOG4105VPB	50S ribosomal protein L30
E3E12_01830	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
E3E12_01835	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
E3E12_01840	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
E3E12_01845	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
E3E12_01850	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
E3E12_01855	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E3E12_01860	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
E3E12_01865	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
E3E12_01870	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
E3E12_01880	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
E3E12_01885	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
E3E12_01890	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
E3E12_01895	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
E3E12_01900	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E3E12_01905	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
E3E12_01910	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
E3E12_01915	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
E3E12_01920	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
E3E12_01925	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
E3E12_01930	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
E3E12_01935	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
E3E12_01940	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E3E12_01945	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E3E12_01955	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
E3E12_01960	ENOG4108VZM	50s ribosomal protein L10
E3E12_01965	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
E3E12_01970	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
E3E12_01975	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
E3E12_01990	ENOG4108JA5	May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs (By similarity)
E3E12_02010	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
E3E12_02015	ENOG4105W1N	transcriptional regulator
E3E12_02020	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
E3E12_02025	ENOG4105CW7	secretion protein, HlyD family
E3E12_02030	ENOG4107S5I	aldo keto reductase
E3E12_02040	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
E3E12_02070	ENOG4105WMR	Protein CrcB homolog
E3E12_02080	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
E3E12_02110	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
E3E12_02125	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
E3E12_02140	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
E3E12_02195	ENOG4108TGR	phosphatase
E3E12_02215	ENOG4105DSW	Fusaric acid resistance protein
E3E12_02220	ENOG4105K59	histidine triad (HIT) protein
E3E12_02235	ENOG4108Z6B	deaminase
E3E12_02240	ENOG4105CBX	hi0933 family
E3E12_02250	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
E3E12_02260	ENOG4107QMS	site-determining protein
E3E12_02265	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
E3E12_02300	ENOG4105N14	lysine exporter protein LysE YggA
E3E12_02335	ENOG4107SV5	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
E3E12_02340	ENOG4107QRT	dEAD DEAH box helicase
E3E12_02350	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
E3E12_02360	ENOG4108NIW	Leucine export protein LeuE
E3E12_02375	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
E3E12_02380	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
E3E12_02425	ENOG4105C8T	Leucyl-tRNA synthetase
E3E12_02455	ENOG4105FE9	pseudouridine synthase
E3E12_02460	ENOG4106H78	methyltransferase
E3E12_02495	ENOG4107QPD	alcohol dehydrogenase
E3E12_02500	ENOG4105C4W	S-formylglutathione hydrolase
E3E12_02505	ENOG4108QBQ	Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione (By similarity)
E3E12_02535	ENOG4105VEQ	Cold shock protein
E3E12_02565	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
E3E12_02590	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
E3E12_02600	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
E3E12_02605	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
E3E12_02610	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
E3E12_02660	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
E3E12_02665	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
E3E12_02670	ENOG4108MG3	formate dehydrogenase
E3E12_02675	ENOG4105F46	Necessary for formate dehydrogenase activity (By similarity)
E3E12_02695	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
E3E12_02705	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
E3E12_02715	ENOG4105CPC	Aldo Keto reductase
E3E12_02745	ENOG4105CQ7	ATP-dependent helicase
E3E12_02750	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
E3E12_02755	ENOG4105CZQ	inner membrane transport protein YdhC
E3E12_02760	ENOG4105F9N	Major Facilitator Superfamily
E3E12_02765	ENOG4108URH	decarboxylase
E3E12_02770	ENOG4105C26	Dehydrogenase
E3E12_02775	ENOG4105EQ2	LysR family Transcriptional regulator
E3E12_02780	ENOG4107RTG	Major Facilitator superfamily
E3E12_02785	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
E3E12_02790	ENOG4105DHP	deoxycytidine triphosphate deaminase
E3E12_02810	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
E3E12_02820	ENOG4105CFG	Acts as a chaperone (By similarity)
E3E12_02825	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
E3E12_02830	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
E3E12_02840	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
E3E12_02845	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
E3E12_02850	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
E3E12_02855	ENOG4105TPV	
E3E12_02860	ENOG4105C10	Electron transfer flavoprotein
E3E12_02870	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
E3E12_02875	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
E3E12_02890	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
E3E12_02895	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
E3E12_02905	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
E3E12_02910	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
E3E12_02945	ENOG4105ENX	hydrolase
E3E12_02955	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
E3E12_02960	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
E3E12_02965	ENOG4108JQC	penicillin-binding protein 1A
E3E12_02970	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
E3E12_02990	ENOG4105SG9	biopolymer transport protein, ExbD
E3E12_03005	ENOG4105D8X	mechanosensitive ion channel
E3E12_03020	ENOG4105KK4	UPF0060 membrane protein
E3E12_03035	ENOG4108JJ9	ABC, transporter
E3E12_03040	ENOG4105BZ1	(ABC) transporter
E3E12_03045	ENOG4105C4M	(Ubiquinol oxidase) subunit I
E3E12_03050	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
E3E12_03060	ENOG4105C85	amino acid
E3E12_03065	ENOG4105BZU	Histidine kinase
E3E12_03070	ENOG4105D01	(LipO)protein
E3E12_03075	ENOG4105D01	(LipO)protein
E3E12_03085	ENOG4108UMI	ABC transporter, permease
E3E12_03120	ENOG4105NF4	modulator of drug activity
E3E12_03130	ENOG4108IND	Tetr family transcriptional regulator
E3E12_03155	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
E3E12_03160	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
E3E12_03165	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E3E12_03190	ENOG4105CIS	alcohol dehydrogenase
E3E12_03200	ENOG4105YK5	50S ribosomal protein L36
E3E12_03215	ENOG4105C25	Primosomal protein n'
E3E12_03230	ENOG4105CH6	catalase
E3E12_03235	ENOG4108RWI	nicotinamidase
E3E12_03250	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
E3E12_03255	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
E3E12_03270	ENOG4105EJQ	L-serine dehydratase
E3E12_03305	ENOG4105TZK	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
E3E12_03325	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
E3E12_03335	ENOG4107QM5	aconitate hydratase
E3E12_03355	ENOG4108VN5	Inherit from COG: PepSY-associated TM helix
E3E12_03360	ENOG4105EUJ	GTP cyclohydrolase i
E3E12_03365	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3E12_03370	ENOG4105EEI	dihydropteroate synthase
E3E12_03380	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
E3E12_03390	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
E3E12_03400	ENOG4108S10	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
E3E12_03410	ENOG4105D6E	homoserine dehydrogenase
E3E12_03415	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
E3E12_03430	ENOG4105E12	capsule polysaccharide
E3E12_03435	ENOG41084CK	capsule polysaccharide
E3E12_03440	ENOG4108TJN	glycosyl transferase group 1
E3E12_03450	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
E3E12_03470	ENOG4105ECX	polysaccharide export
E3E12_03480	ENOG4107RJ7	Glycosyl transferase (Group 1
E3E12_03510	ENOG4105CXG	d-lactate dehydrogenase
E3E12_03515	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
E3E12_03525	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
E3E12_03530	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
E3E12_03535	ENOG4105DTN	riboflavin biosynthesis protein ribF
E3E12_03555	ENOG4105C8Y	Acetylornithine aminotransferase
E3E12_03560	ENOG4105DBV	ornithine carbamoyltransferase
E3E12_03565	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
E3E12_03585	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
E3E12_03595	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
E3E12_03600	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
E3E12_03605	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
E3E12_03610	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
E3E12_03615	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E3E12_03645	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
E3E12_03655	ENOG4105DY2	Paraquat-inducible protein b
E3E12_03660	ENOG4105F1S	paraquat-inducible protein a
E3E12_03675	ENOG4108JU3	Alkyl hydroperoxide reductase
E3E12_03680	ENOG4105D3R	alkyl hydroperoxide reductase
E3E12_03690	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
E3E12_03700	ENOG4105C3J	Cysteine desulfurase
E3E12_03705	ENOG4105C3J	Cysteine desulfurase
E3E12_03720	ENOG4105DHZ	alpha beta
E3E12_03725	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
E3E12_03735	ENOG4105DJV	ribulose-phosphate 3-epimerase
E3E12_03760	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
E3E12_03765	ENOG4105BZS	acriflavin resistance protein
E3E12_03770	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
E3E12_03775	ENOG4105C85	amino acid
E3E12_03785	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
E3E12_03790	ENOG4105E2Z	phosphate ABC transporter (Permease
E3E12_03795	ENOG4105C8U	phosphate abc transporter
E3E12_03805	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
E3E12_03815	ENOG41082K6	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
E3E12_03820	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
E3E12_03830	ENOG4105C5X	domain protein
E3E12_03840	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
E3E12_03850	ENOG4107WK2	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
E3E12_03855	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
E3E12_03860	ENOG4105C3G	gtp-binding protein
E3E12_03865	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
E3E12_03875	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
E3E12_03880	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
E3E12_03895	ENOG4105II7	pyrroline-5-carboxylate reductase
E3E12_03945	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
E3E12_03955	ENOG4108VHN	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E3E12_03965	ENOG4105CKK	Glycosyl transferase, family 2
E3E12_03985	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
E3E12_03995	ENOG4105C7S	Dehydrogenase
E3E12_04000	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
E3E12_04020	ENOG4105CUB	amino acid
E3E12_04025	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
E3E12_04030	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
E3E12_04035	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
E3E12_04040	ENOG4107YTN	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity)
E3E12_04045	ENOG4107QJE	Chromosome Partitioning Protein
E3E12_04050	ENOG4105FA0	parb-like partition protein
E3E12_04060	ENOG4108GH0	ATP-binding protein yghT
E3E12_04065	ENOG4108NDC	ATP-binding protein yghS
E3E12_04090	ENOG4105CKK	Glycosyl transferase, family 2
E3E12_04100	ENOG4108I6E	Sulfatase
E3E12_04120	ENOG4108S55	polysaccharide biosynthesis protein
E3E12_04135	ENOG4105CIG	ABC transporter
E3E12_04145	ENOG4107TE5	Lipid kinase
E3E12_04155	ENOG4108UHJ	MAF-like protein
E3E12_04160	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
E3E12_04165	ENOG4108YXA	Membrane
E3E12_04180	ENOG4105C3S	Mate efflux family protein
E3E12_04200	ENOG4105E3B	Multicopper oxidase
E3E12_04205	ENOG4105VR0	copper resistance
E3E12_04215	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
E3E12_04240	ENOG4107VRP	DNA repair exonuclease
E3E12_04245	ENOG4105DHU	Bile acid
E3E12_04250	ENOG4108HKT	sucrose-6-phosphate hydrolase
E3E12_04255	ENOG4105CV8	reductase
E3E12_04275	ENOG4107QQB	Ribonuclease E
E3E12_04280	ENOG4108Z03	MAF-like protein
E3E12_04285	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
E3E12_04300	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
E3E12_04305	ENOG4107XMU	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E3E12_04330	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
E3E12_04340	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
E3E12_04345	ENOG4108R6K	riboflavin synthase, subunit alpha
E3E12_04350	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
E3E12_04355	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
E3E12_04360	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
E3E12_04365	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
E3E12_04370	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
E3E12_04375	ENOG4105EV9	Alpha Beta Hydrolase
E3E12_04405	ENOG4105EAC	phosphoserine phosphatase
E3E12_04410	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
E3E12_04420	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
E3E12_04425	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
E3E12_04430	ENOG41067V3	Antibiotic biosynthesis monooxygenase
E3E12_04435	ENOG4105C5F	glutamine synthetase
E3E12_04480	ENOG410829K	Lysine exporter protein (Lyse ygga)
E3E12_04485	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
E3E12_04495	ENOG4108UQY	Iron-storage protein
E3E12_04500	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
E3E12_04510	ENOG4105DHJ	ABC, transporter
E3E12_04515	ENOG4105CY3	ABC transporter, permease
E3E12_04525	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
E3E12_04535	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
E3E12_04545	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
E3E12_04560	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
E3E12_04565	ENOG4108UUM	single-stranded DNA-binding protein
E3E12_04600	ENOG4105DEI	Mannitol dehydrogenase
E3E12_04620	ENOG4105CPC	Aldo Keto reductase
E3E12_04625	ENOG4105CMR	udp-glucose 4-epimerase
E3E12_04635	ENOG4105E4C	Lytic transglycosylase catalytic
E3E12_04645	ENOG4108KK1	membrane protein AbrB duplication
E3E12_04655	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
E3E12_04675	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
E3E12_04685	ENOG4108RDT	NADH dehydrogenase NAD(P)H nitroreductase)
E3E12_04710	ENOG41090R7	Ferric uptake
E3E12_04720	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
E3E12_04735	ENOG4105W49	UPF0434 protein
E3E12_04755	ENOG4105K78	MarR family Transcriptional regulator
E3E12_04765	ENOG4105F0N	pyrophosphate phospho-hydrolase
E3E12_04775	ENOG4105C5H	ABC transporter
E3E12_04785	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
E3E12_04805	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
E3E12_04810	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
E3E12_04815	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
E3E12_04820	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
E3E12_04825	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
E3E12_04845	ENOG4108UJU	UPF0301 protein
E3E12_04850	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E3E12_04855	ENOG4107RF4	Phosphodiesterase
E3E12_04870	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
E3E12_04875	ENOG4105DZ1	carboxypeptidase
E3E12_04880	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
E3E12_04895	ENOG4107QMP	dna polymerase iii subunits gamma and tau
E3E12_04900	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
E3E12_04905	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
E3E12_04925	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
E3E12_04930	ENOG4105CAT	Cytidine monophosphate kinase
E3E12_04935	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
E3E12_04960	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
E3E12_04965	ENOG4105C22	threonyL-tRNA synthetase
E3E12_04970	ENOG4105XA0	heptosyltransferase ii
E3E12_04975	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E3E12_04980	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
E3E12_04985	ENOG4105EB3	Histidine kinase
E3E12_04990	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
E3E12_04995	ENOG4105MYN	Zinc uptake regulation protein
E3E12_05000	ENOG4107QNK	)-transporter
E3E12_05005	ENOG4105EGS	Mechanosensitive ion channel
E3E12_05010	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
E3E12_05030	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
E3E12_05035	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
E3E12_05040	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
E3E12_05060	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
E3E12_05065	ENOG4108UJD	30S ribosomal protein S9
E3E12_05070	ENOG4105CM2	brancheD-chain amino acid aminotransferase
E3E12_05080	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
E3E12_05085	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
E3E12_05110	ENOG4105WPN	DNA integration recombination invertion protein
E3E12_05115	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
E3E12_05135	ENOG4108ZZ3	UPF0260 protein
E3E12_05155	ENOG4105Y49	secretion protein, HlyD family
E3E12_05170	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
E3E12_05175	ENOG4105DUX	Transporter
E3E12_05190	ENOG4105DMF	Dehydrogenase
E3E12_05195	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
E3E12_05200	ENOG4105CI3	gtp-binding protein typa
E3E12_05205	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
E3E12_05230	ENOG4105D06	uba thif-type nad fad binding protein
E3E12_05235	ENOG4105DWF	phosphomethylpyrimidine kinase
E3E12_05240	ENOG4105CAY	ferredoxin--nadp reductase
E3E12_05255	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
E3E12_05260	ENOG4105K63	Thioredoxin
E3E12_05265	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
E3E12_05305	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
E3E12_05315	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3E12_05330	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
E3E12_05335	ENOG4105BZA	Phosphoglycerate kinase
E3E12_05340	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E3E12_05355	ENOG4105C2N	RNA methyltransferase TrmH family group 3
E3E12_05365	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
E3E12_05370	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E3E12_05395	ENOG4105C79	DNA protecting protein DprA
E3E12_05400	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
E3E12_05405	ENOG4105CD3	dihydroorotase
E3E12_05410	ENOG4105CXT	aspartate transcarbamylase
E3E12_05415	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
E3E12_05430	ENOG4105CSM	endonuclease III
E3E12_05445	ENOG4105K6T	rare lipoprotein A
E3E12_05450	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
E3E12_05455	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
E3E12_05460	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
E3E12_05470	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
E3E12_05475	ENOG4105CDA	abc transporter atp-binding protein
E3E12_05480	ENOG4105E5Q	amino acid AbC transporter
E3E12_05485	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
E3E12_05500	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
E3E12_05505	ENOG4107ZGG	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
E3E12_05510	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
E3E12_05515	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
E3E12_05520	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
E3E12_05535	ENOG4105CSA	Coproporphyrinogen iii oxidase
E3E12_05540	ENOG4105DFH	Transport of potassium into the cell (By similarity)
E3E12_05545	ENOG4105DFA	alanine racemase domain protein
E3E12_05550	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
E3E12_05560	ENOG4108FN7	Aldo keto reductase
E3E12_05570	ENOG4105PGM	cation diffusion facilitator family transporter
E3E12_05575	ENOG4105DZ0	fad dependent oxidoreductase
E3E12_05585	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
E3E12_05600	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
E3E12_05605	ENOG4105C9Q	fumarate hydratase class II
E3E12_05615	ENOG4105KWW	Biogenesis protein
E3E12_05625	ENOG4105DA4	cytochrome c-type biogenesis protein
E3E12_05630	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
E3E12_05640	ENOG41060IM	Heme exporter protein
E3E12_05650	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
E3E12_05665	ENOG4105D1H	recombination factor protein RarA
E3E12_05695	ENOG4105NWN	ApaG protein
E3E12_05720	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
E3E12_05740	ENOG4105CEP	NADH dehydrogenase
E3E12_05745	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
E3E12_05750	ENOG4105EIN	peptidylprolyl cis-trans isomerase
E3E12_05755	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
E3E12_05760	ENOG4105CDY	transcriptional regulatory protein
E3E12_05765	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
E3E12_05770	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
E3E12_05775	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
E3E12_05780	ENOG4107YD3	Thioesterase
E3E12_05785	ENOG4105E02	MotA TolQ exbB proton channel
E3E12_05790	ENOG4108ZZF	transport protein (ExbD)
E3E12_05800	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
E3E12_05805	ENOG4105KCK	Peptidoglycan-associated lipoprotein
E3E12_05815	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
E3E12_05820	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
E3E12_05825	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
E3E12_05830	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
E3E12_05845	ENOG4105C88	aminopeptidase
E3E12_05850	ENOG4105CIH	Imidazole acetol-phosphate transaminase
E3E12_05860	ENOG4107QP8	phosphohexose isomerase
E3E12_05865	ENOG4108J5G	6-phosphogluconate dehydrogenase
E3E12_05870	ENOG4105DQF	Hydrolase
E3E12_05875	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
E3E12_05880	ENOG4105E66	phosphoriboisomerase A
E3E12_05885	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
E3E12_05905	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
E3E12_05915	ENOG4105C28	cystathionine
E3E12_05930	ENOG4105C2M	dna polymerase I
E3E12_05935	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
E3E12_05945	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
E3E12_05975	ENOG4108T86	baseplate J family protein
E3E12_06030	ENOG4105Y5J	prophage protein
E3E12_06080	ENOG4105CF2	Mu-like prophage FluMu protein GP28
E3E12_06130	ENOG4108WTW	DNA transposition protein
E3E12_06135	ENOG4106YXT	transposase
E3E12_06150	ENOG4105C03	ribonuclease
E3E12_06155	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
E3E12_06165	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
E3E12_06175	ENOG4105CJN	penicillin-binding protein
E3E12_06180	ENOG4105CNI	cell division protein FtsW
E3E12_06185	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
E3E12_06190	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
E3E12_06205	ENOG4105C9M	aspartyl-trna synthetase
E3E12_06220	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
E3E12_06225	ENOG4105C75	arginyL-tRNA synthetase
E3E12_06235	ENOG41081BE	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
E3E12_06240	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
E3E12_06245	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
E3E12_06265	ENOG4105DP0	ferredoxin-NADP reductase
E3E12_06280	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
E3E12_06295	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
E3E12_06310	ENOG4105C8N	cysteinyl-tRNA synthetase
E3E12_06315	ENOG4107QI1	Mate efflux family protein
E3E12_06320	ENOG4105F27	Major Facilitator
E3E12_06325	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
E3E12_06330	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
E3E12_06340	ENOG4107B2H	carbonic anhydrase
E3E12_06345	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
E3E12_06355	ENOG4105D49	3-dehydroquinate synthase
E3E12_06360	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
E3E12_06370	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
E3E12_06375	ENOG4108I62	cina-like protein
E3E12_06385	ENOG4105M6F	mutator MutT protein
E3E12_06395	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
E3E12_06400	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
E3E12_06405	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
E3E12_06410	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
E3E12_06415	ENOG4105C3F	Signal peptidase i
E3E12_06420	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
E3E12_06425	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
E3E12_06430	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
E3E12_06435	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
E3E12_06440	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
E3E12_06445	ENOG4105KNE	Phosphatidate cytidylyltransferase
E3E12_06450	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
E3E12_06455	ENOG4105DZP	Membrane-associated zinc metalloprotease
E3E12_06460	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3E12_06470	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E3E12_06475	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
E3E12_06480	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E3E12_06485	ENOG4105GYT	Protein of unknown function (DUF1009)
E3E12_06495	ENOG4105VG0	50S ribosomal protein l34
E3E12_06500	ENOG41087PG	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
E3E12_06505	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
E3E12_06510	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
E3E12_06515	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
E3E12_06520	ENOG4105CAS	nag kinase
E3E12_06530	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
E3E12_06535	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
E3E12_06540	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
E3E12_06545	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
E3E12_06550	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
E3E12_06555	ENOG4108IUZ	ABC transporter
E3E12_06570	ENOG4105C2X	Arabinose 5-phosphate isomerase
E3E12_06620	ENOG4105HDK	L-asparaginase
E3E12_06630	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
E3E12_06635	ENOG4108RRZ	Transcription elongation factor GreB
E3E12_06640	ENOG4105D7Z	glutathione synthase
E3E12_06645	ENOG4107UX3	phosphatidylethanolamine N-methyltransferase
E3E12_06660	ENOG4105C1V	Peptidase, M16
E3E12_06665	ENOG4105D98	threonine synthase
E3E12_06670	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
E3E12_06675	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
E3E12_06680	ENOG4105CJR	Integral membrane protein (MviN
E3E12_06685	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
E3E12_06690	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E3E12_06695	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
E3E12_06705	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
E3E12_06725	ENOG4105EHG	Permease protein
E3E12_06730	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
E3E12_06735	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
E3E12_06740	ENOG4105CDZ	Carboxymethylenebutenolidase (EC 3.1.1.45)
E3E12_06745	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
E3E12_06750	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
E3E12_06755	ENOG4105DVT	helicase
E3E12_06760	ENOG4105DK7	lysyl-tRNA synthetase
E3E12_06775	ENOG4105HFZ	Membrane
E3E12_06795	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
E3E12_06805	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
E3E12_06815	ENOG4105C5H	ABC transporter
E3E12_06820	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
E3E12_06825	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
E3E12_06830	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
E3E12_06840	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
E3E12_06875	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E3E12_06880	ENOG4105EZR	dyp-type peroxidase family protein
E3E12_06890	ENOG4105CA9	Pyruvate kinase
E3E12_06910	ENOG4105CND	Glycosyl transferase, family 2
E3E12_06915	ENOG4105FBD	synthase
E3E12_06920	ENOG4105FE1	phytoene synthase
E3E12_06940	ENOG4105CE9	30S ribosomal protein S2
E3E12_06945	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
E3E12_06950	ENOG4107UIS	Involved in DNA repair and RecF pathway recombination (By similarity)
E3E12_06955	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E3E12_06960	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
E3E12_06970	ENOG4105C0P	Mg chelatase subunit ChlI
E3E12_06975	ENOG4108JQ1	Dehydrogenase
E3E12_06980	ENOG4107TK4	histidinol-phosphate phosphatase
E3E12_06985	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
E3E12_06990	ENOG4105CQC	Prephenate dehydratase
E3E12_06995	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
E3E12_07000	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
E3E12_07005	ENOG4105VEQ	Cold shock protein
E3E12_07010	ENOG4105CB5	ATP-dependent DNA helicase recG
E3E12_07040	ENOG4105KPV	Transcriptional regulator
E3E12_07050	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
E3E12_07075	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
E3E12_07085	ENOG4105CGK	Exodeoxyribonuclease III
E3E12_07095	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
E3E12_07105	ENOG4105W0E	50S ribosomal protein L33
E3E12_07115	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
E3E12_07120	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
E3E12_07125	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
E3E12_07135	ENOG4105CP7	Triose-phosphate isomerase
E3E12_07145	ENOG4105CRQ	synthase (Component I)
E3E12_07150	ENOG4105DDQ	anthranilate synthase
E3E12_07155	ENOG4107QYG	anthranilate phosphoribosyltransferase
E3E12_07160	ENOG4105DK0	Indole-3-glycerol phosphate synthase
E3E12_07165	ENOG4108JYK	Dehydrogenase
E3E12_07185	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
E3E12_07190	ENOG4108Z1B	Cyclase dehydrase
E3E12_07200	ENOG4105C83	adenylosuccinate lyase
E3E12_07205	ENOG4107QPR	SAICAR synthetase
E3E12_07210	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
E3E12_07220	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
E3E12_07225	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
E3E12_07245	ENOG41082FP	UPF0102 protein
E3E12_07250	ENOG4105D52	delta-aminolevulinic acid dehydratase
E3E12_07255	ENOG4105CUB	amino acid
E3E12_07260	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
E3E12_07265	ENOG4105C1J	atp-dependent rna helicase
E3E12_07290	ENOG4105KVH	Transcriptional regulator
E3E12_07295	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
E3E12_07350	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
E3E12_07355	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
E3E12_07375	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
E3E12_07380	ENOG4105D7W	serine acetyltransferase
E3E12_07410	ENOG4105DQ4	alcohol dehydrogenase
E3E12_07430	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
E3E12_07445	ENOG4105D1F	ATP-binding protein
E3E12_07465	ENOG4105D0A	hydroxylase
E3E12_07475	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
E3E12_07500	ENOG4105DC1	bifunctional purine biosynthesis protein purh
E3E12_07510	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
E3E12_07515	ENOG4105C5I	Dehydrogenase
E3E12_07520	ENOG4105KJF	protein tyrosine phosphatase
E3E12_07525	ENOG4105CUB	amino acid
E3E12_07535	ENOG4105CHH	sulfate transporter
E3E12_07660	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
E3E12_07670	ENOG4105C2C	drug resistance transporter, Bcr CflA
E3E12_07730	ENOG4105CDW	Resistance protein
E3E12_07770	ENOG4105M03	Domain of unknown function (DUF955)
E3E12_08195	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
E3E12_08200	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
E3E12_08205	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
E3E12_08210	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
E3E12_08250	ENOG4107RA9	decarboxylase
E3E12_08270	ENOG4105DFI	Membrane
E3E12_08305	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
E3E12_08310	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
E3E12_08320	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
E3E12_08325	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
E3E12_08345	ENOG41082FS	50S ribosomal protein L31
E3E12_08360	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
E3E12_08370	ENOG4107QMH	DNA methylase
E3E12_08390	ENOG4105W5Q	DNA repair protein (RadC
E3E12_08395	ENOG4105C4R	Atp-dependent dna helicase
E3E12_08410	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
E3E12_08415	ENOG4105H1N	peptidase, M24
E3E12_08435	ENOG4105CV8	reductase
E3E12_08440	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
E3E12_08445	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
E3E12_08450	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
E3E12_08460	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E3E12_08465	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
E3E12_08470	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
E3E12_08475	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
E3E12_08495	ENOG4105C5H	ABC transporter
E3E12_08505	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
E3E12_08510	ENOG4107XZX	Involved in the transcription termination process (By similarity)
E3E12_08515	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
E3E12_08555	ENOG4105IPI	Membrane
E3E12_08560	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
E3E12_08565	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
E3E12_08570	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
E3E12_08575	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
E3E12_08580	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)