locus-tag	class	description
E3E12_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E3E12_00010	COG0592	DNA-directed DNA polymerase activity
E3E12_00035	COG0156	8-amino-7-oxononanoate synthase activity
E3E12_00050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3E12_00070	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E3E12_00075	COG0625	glutathione transferase activity
E3E12_00100	COG1902	pentaerythritol trinitrate reductase activity
E3E12_00115	COG0697	spore germination
E3E12_00180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E3E12_00185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3E12_00190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3E12_00200	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E3E12_00210	COG3590	peptidase
E3E12_00215	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E3E12_00230	COG1136	(ABC) transporter
E3E12_00235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E3E12_00245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E3E12_00250	COG3781	membrane
E3E12_00255	COG1329	Transcriptional regulator
E3E12_00260	COG1028	Short-chain dehydrogenase reductase Sdr
E3E12_00265	COG1028	Short-chain dehydrogenase reductase Sdr
E3E12_00275	COG0729	surface antigen
E3E12_00285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3E12_00290	COG1702	phosphate starvation-inducible protein PhoH
E3E12_00295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E3E12_00300	COG1253	flavin adenine dinucleotide binding
E3E12_00305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3E12_00320	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E3E12_00325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E3E12_00330	COG0142	geranyltranstransferase activity
E3E12_00340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E3E12_00340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3E12_00345	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E3E12_00350	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E3E12_00355	COG0259	pyridoxamine-phosphate oxidase activity
E3E12_00360	COG1519	Transferase
E3E12_00365	COG1663	tetraacyldisaccharide 4'-kinase activity
E3E12_00380	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E3E12_00390	COG3572	ergothioneine biosynthetic process
E3E12_00400	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E3E12_00405	COG1160	GTP binding
E3E12_00420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E3E12_00430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3E12_00435	COG0237	dephospho-CoA kinase activity
E3E12_00440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E3E12_00455	COG0165	Argininosuccinate lyase
E3E12_00470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3E12_00475	COG1234	tRNA 3'-trailer cleavage
E3E12_00480	COG0084	hydrolase, TatD family'
E3E12_00495	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E3E12_00500	COG1686	Belongs to the peptidase S11 family
E3E12_00505	COG2951	lytic endotransglycosylase activity
E3E12_00525	COG1968	undecaprenyl-diphosphatase activity
E3E12_00530	COG0531	amino acid
E3E12_00545	COG2890	protein-(glutamine-N5) methyltransferase activity
E3E12_00560	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E3E12_00565	COG0124	histidyl-tRNA synthetase
E3E12_00570	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E3E12_00580	COG2070	2-Nitropropane dioxygenase
E3E12_00590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3E12_00595	COG2706	6-phosphogluconolactonase activity
E3E12_00605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3E12_00630	COG0321	lipoyl(octanoyl) transferase activity
E3E12_00640	COG0271	Belongs to the BolA IbaG family
E3E12_00645	COG0484	heat shock protein binding
E3E12_00665	COG0587	DNA-directed DNA polymerase activity
E3E12_00670	COG1136	(ABC) transporter
E3E12_00680	COG0442	prolyl-tRNA aminoacylation
E3E12_00690	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E3E12_00705	COG0776	regulation of translation
E3E12_00715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E3E12_00720	COG0740	serine-type endopeptidase activity
E3E12_00725	COG0544	peptidyl-prolyl cis-trans isomerase activity
E3E12_00735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E3E12_00735	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E3E12_00745	COG0513	Belongs to the DEAD box helicase family
E3E12_00750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3E12_00755	COG2151	metal-sulfur cluster biosynthetic enzyme
E3E12_00760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3E12_00765	COG0719	Fe-S assembly protein
E3E12_00770	COG0396	ATPase activity
E3E12_00775	COG0719	Fe-S assembly protein
E3E12_00785	COG2733	membrane
E3E12_00795	COG0038	chloride channel
E3E12_00800	COG0038	chloride channel
E3E12_00805	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E3E12_00810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E3E12_00815	COG5265	(ABC) transporter
E3E12_00825	COG0628	permease
E3E12_00840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E3E12_00845	COG0416	fatty acid biosynthetic process
E3E12_00850	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E3E12_00865	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E3E12_00875	COG0492	ferredoxin-NADP+ reductase activity
E3E12_00880	COG0583	DNA-binding transcription factor activity
E3E12_00890	COG1289	transmembrane transporter activity
E3E12_00900	COG1598	PFAM Uncharacterised protein family UPF0150
E3E12_00925	COG0582	viral genome integration into host DNA
E3E12_00935	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E3E12_00940	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E3E12_00945	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E3E12_00950	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E3E12_00955	COG3750	Belongs to the UPF0335 family
E3E12_00960	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E3E12_00975	COG0275	rRNA processing
E3E12_00990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3E12_01000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3E12_01005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E3E12_01015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E3E12_01020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3E12_01025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E3E12_01030	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3E12_01035	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E3E12_01045	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E3E12_01050	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E3E12_01065	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E3E12_01070	COG1253	flavin adenine dinucleotide binding
E3E12_01090	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E3E12_01100	COG0328	RNA-DNA hybrid ribonuclease activity
E3E12_01105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E3E12_01110	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E3E12_01150	COG0335	large ribosomal subunit rRNA binding
E3E12_01155	COG0336	Belongs to the RNA methyltransferase TrmD family
E3E12_01160	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E3E12_01165	COG0228	four-way junction DNA binding
E3E12_01170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3E12_01190	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E3E12_01235	COG2223	nitrite transmembrane transporter activity
E3E12_01240	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E3E12_01245	COG1140	nitrate reductase beta subunit
E3E12_01250	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E3E12_01255	COG2181	nitrate reductase activity
E3E12_01260	COG0778	Nitroreductase
E3E12_01265	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E3E12_01275	COG0513	Belongs to the DEAD box helicase family
E3E12_01280	COG0778	Nitroreductase
E3E12_01300	COG1692	metallophosphoesterase
E3E12_01305	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E3E12_01330	COG0352	thiamine-phosphate diphosphorylase activity
E3E12_01340	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E3E12_01345	COG1509	lysine 2,3-aminomutase activity
E3E12_01355	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E3E12_01360	COG0483	inositol monophosphate 1-phosphatase activity
E3E12_01370	COG0481	GTPase activity
E3E12_01380	COG1722	exodeoxyribonuclease VII activity
E3E12_01385	COG0142	geranyltranstransferase activity
E3E12_01390	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E3E12_01395	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E3E12_01400	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E3E12_01410	COG0137	argininosuccinate synthase activity
E3E12_01415	COG0545	Peptidyl-prolyl cis-trans isomerase
E3E12_01420	COG0180	Tryptophanyl-tRNA synthetase
E3E12_01430	COG1401	restriction endodeoxyribonuclease activity
E3E12_01435	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3E12_01440	COG0072	phenylalanine-tRNA ligase activity
E3E12_01440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3E12_01445	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E3E12_01450	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E3E12_01455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E3E12_01505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3E12_01510	COG0688	phosphatidylethanolamine metabolic process
E3E12_01515	COG1183	phosphatidylcholine synthase activity
E3E12_01525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3E12_01530	COG1218	3'(2'),5'-bisphosphate nucleotidase
E3E12_01535	COG0009	L-threonylcarbamoyladenylate synthase
E3E12_01555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3E12_01560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E3E12_01580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E3E12_01590	COG0359	binds to the 23S rRNA
E3E12_01595	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E3E12_01600	COG0360	Binds together with S18 to 16S ribosomal RNA
E3E12_01610	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E3E12_01625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3E12_01630	COG0358	DNA primase activity
E3E12_01640	COG0505	Belongs to the CarA family
E3E12_01645	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E3E12_01650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3E12_01660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3E12_01665	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3E12_01675	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E3E12_01685	COG1289	transmembrane transporter activity
E3E12_01690	COG0793	Belongs to the peptidase S41A family
E3E12_01695	COG0494	nUDIX hydrolase
E3E12_01700	COG1132	(ABC) transporter
E3E12_01710	COG0714	Associated with various cellular activities
E3E12_01735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3E12_01740	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E3E12_01745	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E3E12_01765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3E12_01770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3E12_01780	COG1538	Outer membrane efflux protein
E3E12_01790	COG0203	ribosomal protein L17
E3E12_01795	COG0202	RNA polymerase activity
E3E12_01800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E3E12_01805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E3E12_01810	COG0563	adenylate kinase activity
E3E12_01820	COG0200	Binds to the 23S rRNA
E3E12_01825	COG1841	ribosomal large subunit assembly
E3E12_01830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E3E12_01835	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E3E12_01840	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E3E12_01845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E3E12_01850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E3E12_01855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E3E12_01860	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E3E12_01865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E3E12_01870	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E3E12_01875	COG0255	Belongs to the universal ribosomal protein uL29 family
E3E12_01880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E3E12_01885	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E3E12_01890	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E3E12_01895	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E3E12_01900	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E3E12_01905	COG0089	rRNA binding
E3E12_01910	COG0088	Forms part of the polypeptide exit tunnel
E3E12_01915	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E3E12_01920	COG0051	transcription antitermination factor activity, RNA binding
E3E12_01925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E3E12_01930	COG0049	tRNA binding
E3E12_01935	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E3E12_01940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E3E12_01945	COG0085	RNA polymerase activity
E3E12_01955	COG0222	ribosome binding
E3E12_01960	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E3E12_01965	COG0081	regulation of translation
E3E12_01970	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E3E12_01975	COG1538	Outer membrane efflux protein
E3E12_02010	COG1538	Outer membrane efflux protein
E3E12_02015	COG3226	Transcriptional regulator
E3E12_02020	COG2814	Major facilitator Superfamily
E3E12_02025	COG1566	PFAM secretion protein HlyD family protein
E3E12_02030	COG0667	Aldo Keto reductase
E3E12_02040	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E3E12_02070	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E3E12_02080	COG1970	mechanosensitive ion channel activity
E3E12_02110	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E3E12_02125	COG0167	dihydroorotate dehydrogenase activity
E3E12_02140	COG1902	pentaerythritol trinitrate reductase activity
E3E12_02195	COG0406	alpha-ribazole phosphatase activity
E3E12_02215	COG1289	transmembrane transporter activity
E3E12_02235	COG0590	tRNA wobble adenosine to inosine editing
E3E12_02240	COG2081	HI0933 family
E3E12_02250	COG0850	regulation of cytokinetic process
E3E12_02260	COG2894	cell division
E3E12_02265	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E3E12_02300	COG1280	lysine exporter protein (LysE YggA)
E3E12_02335	COG1518	maintenance of DNA repeat elements
E3E12_02340	COG1201	RNA secondary structure unwinding
E3E12_02350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3E12_02360	COG1280	lysine exporter protein (LysE YggA)
E3E12_02375	COG0131	Imidazoleglycerol-phosphate dehydratase
E3E12_02380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E3E12_02425	COG0495	leucyl-tRNA aminoacylation
E3E12_02445	COG1432	Conserved Protein
E3E12_02450	COG1278	Cold shock
E3E12_02455	COG1187	pseudouridine synthase activity
E3E12_02460	COG0742	ribosomal rna small subunit methyltransferase
E3E12_02470	COG0564	pseudouridine synthase activity
E3E12_02500	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E3E12_02505	COG3791	Glutathione-dependent formaldehyde-activating
E3E12_02535	COG1278	Cold shock
E3E12_02565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3E12_02585	COG1959	2 iron, 2 sulfur cluster binding
E3E12_02590	COG2824	Alkylphosphonate utilization operon protein PhnA
E3E12_02600	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E3E12_02605	COG0107	imidazoleglycerol-phosphate synthase activity
E3E12_02610	COG0140	phosphoribosyl-ATP diphosphatase activity
E3E12_02620	COG0384	phenazine biosynthesis protein PhzF
E3E12_02660	COG0243	molybdopterin cofactor binding
E3E12_02660	COG3383	formate dehydrogenase (NAD+) activity
E3E12_02665	COG0437	4 iron, 4 sulfur cluster binding
E3E12_02670	COG2864	formate dehydrogenase
E3E12_02695	COG0723	plastoquinol--plastocyanin reductase activity
E3E12_02705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E3E12_02705	COG2857	Cytochrome c1
E3E12_02715	COG0667	Aldo Keto reductase
E3E12_02725	COG2205	protein histidine kinase activity
E3E12_02745	COG1643	Atp-dependent helicase
E3E12_02750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E3E12_02755	COG2814	Major facilitator Superfamily
E3E12_02760	COG2814	Major facilitator Superfamily
E3E12_02770	COG1012	belongs to the aldehyde dehydrogenase family
E3E12_02785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E3E12_02790	COG0717	Belongs to the dCTP deaminase family
E3E12_02810	COG0438	transferase activity, transferring glycosyl groups
E3E12_02820	COG0443	Heat shock 70 kDa protein
E3E12_02825	COG0484	heat shock protein binding
E3E12_02830	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E3E12_02840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E3E12_02845	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E3E12_02850	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E3E12_02850	COG0644	oxidoreductase
E3E12_02870	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E3E12_02875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3E12_02890	COG0133	tryptophan synthase activity
E3E12_02895	COG0159	tryptophan synthase activity
E3E12_02905	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E3E12_02910	COG0285	dihydrofolate synthase activity
E3E12_02915	COG0305	Participates in initiation and elongation during chromosome replication
E3E12_02945	COG1073	alpha beta
E3E12_02955	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E3E12_02960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E3E12_02965	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E3E12_03005	COG0668	transmembrane transport
E3E12_03020	COG1742	UPF0060 membrane protein
E3E12_03035	COG4988	ABC transporter
E3E12_03040	COG1132	(ABC) transporter
E3E12_03045	COG1271	oxidase subunit
E3E12_03050	COG1294	oxidase, subunit
E3E12_03060	COG1113	amino acid transport
E3E12_03065	COG0004	ammonium transporteR
E3E12_03085	COG2011	ABC-type metal ion transport system permease component
E3E12_03120	COG2249	NAD(P)H dehydrogenase (quinone) activity
E3E12_03130	COG1309	transcriptional regulator
E3E12_03155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E3E12_03160	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E3E12_03165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3E12_03190	COG0604	alcohol dehydrogenase
E3E12_03200	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E3E12_03230	COG0753	catalase activity
E3E12_03235	COG1335	isochorismatase
E3E12_03250	COG0602	queuosine metabolic process
E3E12_03255	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E3E12_03270	COG1760	l-serine dehydratase
E3E12_03305	COG1518	maintenance of DNA repeat elements
E3E12_03325	COG0473	3-isopropylmalate dehydrogenase activity
E3E12_03350	COG4774	siderophore transport
E3E12_03360	COG0302	gtp cyclohydrolase
E3E12_03365	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3E12_03370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E3E12_03380	COG0405	Gamma-glutamyltransferase
E3E12_03390	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E3E12_03400	COG0740	serine-type endopeptidase activity
E3E12_03415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E3E12_03415	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E3E12_03450	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E3E12_03450	COG0662	Cupin 2, conserved barrel domain protein
E3E12_03455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3E12_03480	COG0438	transferase activity, transferring glycosyl groups
E3E12_03510	COG0277	FAD linked oxidase domain protein
E3E12_03515	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E3E12_03525	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E3E12_03530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E3E12_03535	COG0196	riboflavin kinase activity
E3E12_03540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3E12_03555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3E12_03560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E3E12_03565	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E3E12_03590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3E12_03595	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E3E12_03600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E3E12_03605	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E3E12_03610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E3E12_03615	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E3E12_03645	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E3E12_03655	COG3008	intermembrane lipid transfer
E3E12_03660	COG2995	paraquat-inducible protein a
E3E12_03680	COG0450	alkyl hydroperoxide reductase
E3E12_03690	COG0482	sulfurtransferase activity
E3E12_03700	COG1104	cysteine desulfurase activity
E3E12_03705	COG1104	cysteine desulfurase activity
E3E12_03720	COG2945	thiolester hydrolase activity
E3E12_03725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E3E12_03735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3E12_03760	COG1538	Outer membrane efflux protein
E3E12_03770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3E12_03775	COG1113	amino acid transport
E3E12_03780	COG0704	Plays a role in the regulation of phosphate uptake
E3E12_03785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3E12_03795	COG0573	inorganic phosphate transmembrane transporter activity
E3E12_03805	COG0156	8-amino-7-oxononanoate synthase activity
E3E12_03815	COG4106	trans-aconitate 2-methyltransferase activity
E3E12_03820	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E3E12_03820	COG4106	trans-aconitate 2-methyltransferase activity
E3E12_03830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3E12_03840	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E3E12_03845	COG0799	negative regulation of ribosome biogenesis
E3E12_03850	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E3E12_03855	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E3E12_03860	COG0012	GTP binding
E3E12_03865	COG0193	aminoacyl-tRNA hydrolase activity
E3E12_03870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E3E12_03880	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E3E12_03945	COG0356	it plays a direct role in the translocation of protons across the membrane
E3E12_03950	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E3E12_03955	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E3E12_03960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E3E12_03965	COG0463	Glycosyl transferase, family 2
E3E12_03985	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E3E12_03995	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3E12_04000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E3E12_04020	COG0531	amino acid
E3E12_04025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3E12_04030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E3E12_04035	COG0445	tRNA wobble uridine modification
E3E12_04040	COG0357	Ribosomal RNA small subunit methyltransferase G
E3E12_04045	COG1192	Involved in chromosome partitioning
E3E12_04050	COG1475	DNA binding
E3E12_04060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E3E12_04065	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E3E12_04090	COG0463	Glycosyl transferase, family 2
E3E12_04100	COG2194	sulfuric ester hydrolase activity
E3E12_04120	COG2244	polysaccharide biosynthetic process
E3E12_04155	COG0424	maF-like protein
E3E12_04160	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E3E12_04180	COG0534	Mate efflux family protein
E3E12_04200	COG2132	Multicopper oxidase
E3E12_04205	COG3667	copper resistance
E3E12_04215	COG0326	Molecular chaperone. Has ATPase activity
E3E12_04240	COG0420	3'-5' exonuclease activity
E3E12_04250	COG1621	beta-fructofuranosidase activity
E3E12_04255	COG0656	L-ascorbic acid biosynthetic process
E3E12_04270	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E3E12_04275	COG1530	ribonuclease E activity
E3E12_04280	COG0424	maF-like protein
E3E12_04285	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E3E12_04300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E3E12_04305	COG0588	phosphoglycerate mutase activity
E3E12_04330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3E12_04340	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3E12_04340	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3E12_04345	COG0307	riboflavin synthase, alpha
E3E12_04350	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E3E12_04350	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E3E12_04355	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E3E12_04360	COG0194	GDP metabolic process
E3E12_04365	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E3E12_04370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E3E12_04375	COG0596	Alpha beta hydrolase
E3E12_04380	COG1064	alcohol dehydrogenase
E3E12_04385	COG3961	Belongs to the TPP enzyme family
E3E12_04405	COG0560	Phosphoserine phosphatase
E3E12_04410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E3E12_04420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E3E12_04425	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E3E12_04430	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E3E12_04450	COG0702	epimerase
E3E12_04500	COG2814	Major facilitator Superfamily
E3E12_04510	COG1127	ABC transporter
E3E12_04515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E3E12_04525	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E3E12_04535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E3E12_04545	COG4232	protein-disulfide reductase activity
E3E12_04550	COG5001	Diguanylate cyclase
E3E12_04560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E3E12_04565	COG0629	single-stranded DNA binding
E3E12_04600	COG0246	Mannitol dehydrogenase
E3E12_04620	COG0667	Aldo Keto reductase
E3E12_04625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3E12_04635	COG0741	lytic transglycosylase activity
E3E12_04645	COG3180	Ammonia monooxygenase
E3E12_04655	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E3E12_04655	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E3E12_04675	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E3E12_04685	COG0778	Nitroreductase
E3E12_04705	COG4957	zinc ion binding
E3E12_04720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E3E12_04735	COG2835	tetraacyldisaccharide 4'-kinase activity
E3E12_04755	COG3189	MarR family transcriptional regulator
E3E12_04765	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E3E12_04775	COG0488	(ABC) transporter
E3E12_04785	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E3E12_04805	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E3E12_04810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E3E12_04815	COG0552	protein localization to endoplasmic reticulum
E3E12_04820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3E12_04825	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E3E12_04845	COG1678	Uncharacterized ACR, COG1678
E3E12_04850	COG0542	response to heat
E3E12_04855	COG5212	phosphodiesterase
E3E12_04875	COG1686	Belongs to the peptidase S11 family
E3E12_04880	COG0024	Methionine aminopeptidase
E3E12_04895	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E3E12_04900	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E3E12_04905	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E3E12_04910	COG1028	Short-chain dehydrogenase reductase Sdr
E3E12_04925	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E3E12_04930	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E3E12_04935	COG0539	negative regulation of cytoplasmic translation
E3E12_04940	COG0612	Peptidase, M16
E3E12_04960	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E3E12_04965	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E3E12_04975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E3E12_04980	COG0745	RESPONSE REGULATOR receiver
E3E12_04985	COG2205	protein histidine kinase activity
E3E12_04990	COG1660	Displays ATPase and GTPase activities
E3E12_04995	COG0735	belongs to the Fur family
E3E12_05000	COG2814	Major facilitator Superfamily
E3E12_05005	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E3E12_05005	COG3264	Mechanosensitive ion channel
E3E12_05010	COG0167	dihydroorotate dehydrogenase activity
E3E12_05030	COG2204	response regulator
E3E12_05035	COG1923	regulation of RNA biosynthetic process
E3E12_05040	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3E12_05060	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E3E12_05065	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E3E12_05070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3E12_05075	COG0303	'Molybdopterin
E3E12_05080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E3E12_05085	COG0315	cyclic pyranopterin monophosphate synthase activity
E3E12_05090	COG0315	cyclic pyranopterin monophosphate synthase activity
E3E12_05090	COG0746	molybdenum cofactor guanylyltransferase activity
E3E12_05095	COG0314	molybdopterin synthase activity
E3E12_05105	COG1956	GAF domain-containing protein
E3E12_05110	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E3E12_05115	COG1028	Short-chain dehydrogenase reductase Sdr
E3E12_05135	COG2983	Belongs to the UPF0260 family
E3E12_05190	COG1304	FMN binding
E3E12_05195	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E3E12_05205	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E3E12_05230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3E12_05235	COG0351	phosphomethylpyrimidine kinase
E3E12_05235	COG0352	thiamine-phosphate diphosphorylase activity
E3E12_05235	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E3E12_05240	COG0492	ferredoxin-NADP+ reductase activity
E3E12_05255	COG1074	ATP-dependent DNA helicase activity
E3E12_05265	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E3E12_05280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3E12_05305	COG0535	radical SAM domain protein
E3E12_05310	COG1253	flavin adenine dinucleotide binding
E3E12_05315	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3E12_05335	COG0126	phosphoglycerate kinase activity
E3E12_05340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3E12_05345	COG0564	pseudouridine synthase activity
E3E12_05370	COG0187	DNA topoisomerase II activity
E3E12_05385	COG2885	chlorophyll binding
E3E12_05385	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E3E12_05390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3E12_05395	COG0758	DNA mediated transformation
E3E12_05400	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E3E12_05405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E3E12_05410	COG0540	Belongs to the ATCase OTCase family
E3E12_05415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3E12_05430	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3E12_05445	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E3E12_05450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E3E12_05455	COG0511	ligase activity, forming carbon-carbon bonds
E3E12_05460	COG0439	Biotin carboxylase
E3E12_05470	COG4133	protoheme IX ABC transporter activity
E3E12_05475	COG1126	abc transporter atp-binding protein
E3E12_05480	COG0765	amino acid transport
E3E12_05485	COG0779	Required for maturation of 30S ribosomal subunits
E3E12_05500	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E3E12_05505	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E3E12_05510	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E3E12_05515	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E3E12_05520	COG1185	polyribonucleotide nucleotidyltransferase activity
E3E12_05535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3E12_05540	COG3158	transport of potassium into the cell
E3E12_05545	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E3E12_05560	COG0667	Aldo Keto reductase
E3E12_05565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E3E12_05575	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E3E12_05585	COG0156	8-amino-7-oxononanoate synthase activity
E3E12_05600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E3E12_05605	COG0114	fumarate hydratase activity
E3E12_05615	COG3088	subunit of a heme lyase
E3E12_05625	COG1138	Cytochrome C-type biogenesis protein
E3E12_05630	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E3E12_05640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3E12_05650	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E3E12_05665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3E12_05670	COG0564	pseudouridine synthase activity
E3E12_05720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3E12_05740	COG1252	NADH dehydrogenase
E3E12_05745	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E3E12_05750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3E12_05755	COG0653	protein targeting
E3E12_05760	COG0217	transcriptional regulatory protein
E3E12_05770	COG0632	four-way junction helicase activity
E3E12_05775	COG2255	four-way junction helicase activity
E3E12_05780	COG0824	Thioesterase
E3E12_05785	COG0811	peptide transport
E3E12_05790	COG0848	biopolymer transport protein
E3E12_05800	COG0823	Involved in the tonB-independent uptake of proteins
E3E12_05805	COG2885	chlorophyll binding
E3E12_05815	COG0037	tRNA processing
E3E12_05820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3E12_05825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3E12_05830	COG0745	RESPONSE REGULATOR receiver
E3E12_05850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E3E12_05860	COG0166	Belongs to the GPI family
E3E12_05865	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
E3E12_05870	COG0561	phosphatase activity
E3E12_05875	COG0363	glucosamine-6-phosphate deaminase activity
E3E12_05880	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E3E12_05885	COG3265	gluconokinase activity
E3E12_05905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E3E12_05930	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3E12_05930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3E12_05935	COG0546	phosphoglycolate phosphatase activity
E3E12_05945	COG1570	exodeoxyribonuclease VII activity
E3E12_05975	COG3299	homolog of phage Mu protein gp47
E3E12_06030	COG4387	Mu-like prophage protein GP36
E3E12_06080	COG4373	Mu-like prophage FluMu protein gp28
E3E12_06130	COG2842	Transposition protein
E3E12_06135	COG2801	Transposase and inactivated derivatives
E3E12_06150	COG1530	ribonuclease E activity
E3E12_06175	COG0768	penicillin binding
E3E12_06180	COG0772	Belongs to the SEDS family
E3E12_06185	COG0751	glycine-tRNA ligase activity
E3E12_06190	COG0752	glycyl-tRNA synthetase alpha subunit
E3E12_06205	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E3E12_06220	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E3E12_06225	COG0018	arginyl-trna synthetase
E3E12_06235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3E12_06240	COG0805	protein transport
E3E12_06245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E3E12_06280	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E3E12_06295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3E12_06310	COG0215	cysteine-tRNA ligase activity
E3E12_06320	COG2814	Major facilitator Superfamily
E3E12_06325	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E3E12_06345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E3E12_06350	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E3E12_06350	COG2885	chlorophyll binding
E3E12_06355	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E3E12_06370	COG0825	malonyl-CoA metabolic process
E3E12_06375	COG1058	Belongs to the CinA family
E3E12_06375	COG1546	Belongs to the CinA family
E3E12_06385	COG0494	nUDIX hydrolase
E3E12_06395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E3E12_06400	COG1758	RNA polymerase activity
E3E12_06405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3E12_06410	COG0736	holo-[acyl-carrier-protein] synthase activity
E3E12_06415	COG0681	Belongs to the peptidase S26 family
E3E12_06420	COG0571	ribonuclease III activity
E3E12_06425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E3E12_06430	COG0528	UMP kinase activity
E3E12_06435	COG0233	cytoplasmic translational termination
E3E12_06440	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E3E12_06445	COG0575	Belongs to the CDS family
E3E12_06450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E3E12_06455	COG0750	zinc metalloprotease
E3E12_06460	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3E12_06470	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3E12_06475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E3E12_06480	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3E12_06485	COG3494	Protein of unknown function (DUF1009)
E3E12_06490	COG0346	lactoylglutathione lyase activity
E3E12_06495	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E3E12_06500	COG0594	ribonuclease P activity
E3E12_06505	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E3E12_06510	COG0706	membrane insertase activity
E3E12_06515	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E3E12_06520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E3E12_06530	COG2171	N-acyltransferase activity
E3E12_06535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3E12_06540	COG0101	tRNA pseudouridine synthase activity
E3E12_06545	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E3E12_06550	COG0242	peptide deformylase activity
E3E12_06555	COG1137	ATPase activity
E3E12_06570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E3E12_06570	COG0517	IMP dehydrogenase activity
E3E12_06590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E3E12_06620	COG0252	asparaginase activity
E3E12_06625	COG2985	domain, Protein
E3E12_06630	COG0556	nucleotide-excision repair
E3E12_06640	COG0189	ligase activity
E3E12_06650	COG0655	NAD(P)H dehydrogenase (quinone) activity
E3E12_06660	COG0612	Peptidase, M16
E3E12_06670	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E3E12_06675	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E3E12_06680	COG0728	peptidoglycan biosynthetic process
E3E12_06685	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E3E12_06690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E3E12_06695	COG0181	hydroxymethylbilane synthase activity
E3E12_06705	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E3E12_06725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3E12_06730	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E3E12_06735	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E3E12_06740	COG0412	Dienelactone hydrolase
E3E12_06745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E3E12_06750	COG0459	protein refolding
E3E12_06755	COG1199	ATP-dependent helicase activity
E3E12_06760	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E3E12_06775	COG0670	Belongs to the BI1 family
E3E12_06795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3E12_06815	COG0488	(ABC) transporter
E3E12_06820	COG0105	UTP biosynthetic process
E3E12_06825	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E3E12_06830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E3E12_06840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E3E12_06845	COG0248	Ppx GppA phosphatase
E3E12_06855	COG0019	diaminopimelate decarboxylase activity
E3E12_06875	COG0519	Catalyzes the synthesis of GMP from XMP
E3E12_06875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E3E12_06880	COG2837	iron assimilation
E3E12_06890	COG0469	pyruvate kinase activity
E3E12_06905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3E12_06910	COG1215	transferase activity, transferring glycosyl groups
E3E12_06915	COG1562	ergosterol biosynthetic process
E3E12_06920	COG1562	ergosterol biosynthetic process
E3E12_06925	COG1233	COG1233 Phytoene dehydrogenase and related
E3E12_06930	COG1657	PFAM Prenyltransferase squalene oxidase
E3E12_06940	COG0052	Belongs to the universal ribosomal protein uS2 family
E3E12_06945	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E3E12_06950	COG1381	Involved in DNA repair and RecF pathway recombination
E3E12_06955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3E12_06960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3E12_06970	COG0606	chelatase, subunit chli
E3E12_06975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3E12_06980	COG0483	inositol monophosphate 1-phosphatase activity
E3E12_06985	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E3E12_06990	COG0077	Prephenate dehydratase
E3E12_06990	COG1605	Chorismate mutase
E3E12_06995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3E12_07000	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E3E12_07010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E3E12_07015	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E3E12_07040	COG1959	2 iron, 2 sulfur cluster binding
E3E12_07050	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E3E12_07085	COG0708	Exodeoxyribonuclease III
E3E12_07095	COG0322	excinuclease ABC activity
E3E12_07105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E3E12_07115	COG0148	phosphopyruvate hydratase activity
E3E12_07120	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E3E12_07125	COG0504	CTP synthase activity
E3E12_07135	COG0149	triose-phosphate isomerase activity
E3E12_07145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3E12_07155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3E12_07160	COG0134	indole-3-glycerol-phosphate synthase activity
E3E12_07165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E3E12_07170	COG0022	dehydrogenase e1 component
E3E12_07170	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3E12_07175	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3E12_07180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3E12_07185	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E3E12_07190	COG2867	negative regulation of translational initiation
E3E12_07200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E3E12_07205	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E3E12_07210	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3E12_07220	COG0047	phosphoribosylformylglycinamidine synthase activity
E3E12_07225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3E12_07235	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E3E12_07245	COG0792	nuclease activity
E3E12_07250	COG0113	porphobilinogen synthase activity
E3E12_07255	COG0531	amino acid
E3E12_07260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E3E12_07265	COG0513	Belongs to the DEAD box helicase family
E3E12_07290	COG1733	regulation of RNA biosynthetic process
E3E12_07295	COG1538	Outer membrane efflux protein
E3E12_07350	COG0343	queuine tRNA-ribosyltransferase activity
E3E12_07355	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E3E12_07365	COG2853	Lipoprotein
E3E12_07410	COG1064	alcohol dehydrogenase
E3E12_07430	COG0484	heat shock protein binding
E3E12_07445	COG0489	protein tyrosine kinase activity
E3E12_07465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3E12_07475	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E3E12_07485	COG0129	dihydroxy-acid dehydratase activity
E3E12_07490	COG0800	Aldolase
E3E12_07500	COG0138	bifunctional purine biosynthesis protein purh
E3E12_07510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E3E12_07515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3E12_07520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3E12_07525	COG0531	amino acid
E3E12_07535	COG0659	secondary active sulfate transmembrane transporter activity
E3E12_07660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3E12_07670	COG2814	Major facilitator Superfamily
E3E12_07730	COG3853	Toxic anion resistance protein (TelA)
E3E12_07760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3E12_07770	COG2856	Zn peptidase
E3E12_08050	COG0837	glucose binding
E3E12_08195	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E3E12_08200	COG0154	amidase activity
E3E12_08205	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E3E12_08210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E3E12_08250	COG3961	Belongs to the TPP enzyme family
E3E12_08270	COG0697	spore germination
E3E12_08305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E3E12_08310	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E3E12_08320	COG0284	orotidine-5'-phosphate decarboxylase activity
E3E12_08325	COG0135	phosphoribosylanthranilate isomerase activity
E3E12_08345	COG0254	rRNA binding
E3E12_08360	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E3E12_08370	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E3E12_08395	COG0210	DNA helicase
E3E12_08410	COG2264	protein methyltransferase activity
E3E12_08415	COG0006	proline dipeptidase activity
E3E12_08435	COG0656	L-ascorbic acid biosynthetic process
E3E12_08440	COG0525	valine-tRNA ligase activity
E3E12_08445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E3E12_08450	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E3E12_08460	COG0187	DNA topoisomerase II activity
E3E12_08465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E3E12_08475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3E12_08505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E3E12_08510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3E12_08515	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E3E12_08555	COG0628	permease
E3E12_08560	COG0756	dUTP diphosphatase activity
E3E12_08565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3E12_08570	COG2226	methyltransferase
E3E12_08575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3E12_08580	COG0268	Binds directly to 16S ribosomal RNA
E3E12_08755	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs