locus-tag	class	description
STH1	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
STH10	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
STH1000	COG0626	cystathionine gamma-synthase activity
STH1001	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
STH1002	COG1525	nuclease
STH1002	COG4085	toxin activity
STH1002	COG0737	Belongs to the 5'-nucleotidase family
STH1004	COG0217	transcriptional regulatory protein
STH1005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
STH1008	COG0166	Belongs to the GPI family
STH1009	COG0724	RNA recognition motif
STH101	COG2385	sporulation resulting in formation of a cellular spore
STH1010	COG2059	Chromate
STH1013	COG0726	polysaccharide deacetylase
STH1022	COG2203	Gaf domain
STH1022	COG4585	Histidine kinase
STH1025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STH1026	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
STH1028	COG1151	hydroxylamine reductase activity
STH1029	COG0860	N-Acetylmuramoyl-L-alanine amidase
STH103	COG1609	Transcriptional regulator
STH1031	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
STH1032	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
STH1036	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH1037	COG0601	transmembrane transport
STH104	COG1077	Cell shape determining protein MreB Mrl
STH1040	COG5002	protein histidine kinase activity
STH1040	COG2205	protein histidine kinase activity
STH1040	COG0784	Response regulator, receiver
STH1041	COG0745	RESPONSE REGULATOR receiver
STH1043	COG4166	transmembrane transport
STH1045	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
STH1050	COG1801	Protein of unknown function DUF72
STH1051	COG1595	DNA-templated transcription, initiation
STH1054	COG0617	tRNA 3'-terminal CCA addition
STH1060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
STH1066	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
STH107	COG2391	methyltransferase activity
STH1071	COG1575	Belongs to the MenA family. Type 1 subfamily
STH1075	COG1876	peptidase activity
STH1076	COG0739	heme binding
STH1078	COG1683	Conserved Protein
STH1079	COG1363	Peptidase, m42
STH108	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
STH1080	COG1363	Peptidase, m42
STH1082	COG0840	transmembrane signaling receptor activity
STH1084	COG0805	protein transport
STH1085	COG0488	(ABC) transporter
STH1089	COG3409	Peptidoglycan-binding domain 1 protein
STH1089	COG3773	Cell wall hydrolase
STH1090	COG2959	enzyme of heme biosynthesis
STH1091	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
STH1092	COG0291	Belongs to the bacterial ribosomal protein bL35 family
STH1093	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
STH1094	COG0569	domain protein
STH1095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
STH1096	COG0569	domain protein
STH1097	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
STH1102	COG0728	peptidoglycan biosynthetic process
STH1105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
STH1106	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
STH1106	COG0072	phenylalanine-tRNA ligase activity
STH1108	COG0601	transmembrane transport
STH1109	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH1110	COG0444	Belongs to the ABC transporter superfamily
STH1111	COG4608	Belongs to the ABC transporter superfamily
STH1112	COG0488	(ABC) transporter
STH1114	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
STH1115	COG1193	negative regulation of DNA recombination
STH1116	COG1078	dGTPase activity
STH1122	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
STH1124	COG3344	reverse transcriptase
STH1126	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
STH113	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
STH114	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
STH1142	COG0175	sulfate reduction
STH1143	COG2046	Belongs to the sulfate adenylyltransferase family
STH1145	COG3842	ATPase activity
STH1148	COG1473	amidohydrolase
STH1149	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
STH1155	COG4149	molybdate abc transporter
STH1156	COG3842	ATPase activity
STH1157	COG1840	ABC-type Fe3 transport system, periplasmic component
STH1158	COG1316	TRANSCRIPTIONal
STH1159	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
STH1160	COG0632	four-way junction helicase activity
STH1161	COG2255	four-way junction helicase activity
STH1162	COG1191	sigma factor activity
STH1164	COG2385	sporulation resulting in formation of a cellular spore
STH1165	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
STH1166	COG0343	queuine tRNA-ribosyltransferase activity
STH1168	COG1862	Preprotein translocase
STH1169	COG2197	response regulator
STH117	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
STH1170	COG2719	SpoVR family
STH1171	COG2718	Belongs to the UPF0229 family
STH1172	COG2766	serine protein kinase
STH1173	COG1846	Transcriptional regulator
STH1177	COG2197	response regulator
STH118	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
STH1186	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STH1186	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STH1187	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STH1187	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STH1188	COG0346	lactoylglutathione lyase activity
STH1189	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
STH1190	COG5016	pyruvate
STH1190	COG0511	ligase activity, forming carbon-carbon bonds
STH1191	COG0439	Biotin carboxylase
STH1192	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
STH1195	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
STH12	COG4166	transmembrane transport
STH1200	COG2001	Belongs to the MraZ family
STH1201	COG0275	rRNA processing
STH1203	COG0505	Belongs to the CarA family
STH1204	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
STH1205	COG0768	penicillin binding
STH1206	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
STH1208	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
STH1209	COG0772	Belongs to the SEDS family
STH121	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
STH1210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
STH1211	COG0812	UDP-N-acetylmuramate dehydrogenase activity
STH1212	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
STH1214	COG1597	lipid kinase activity
STH1215	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
STH1216	COG3879	Bacterial protein of unknown function (DUF881)
STH1217	COG3856	small basic protein
STH1219	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
STH122	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
STH1221	COG1191	sigma factor activity
STH1222	COG1191	sigma factor activity
STH1227	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
STH1228	COG1799	cell septum assembly
STH123	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
STH1230	COG3599	regulation of cell shape
STH1231	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
STH1232	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
STH1237	COG1574	metal-dependent hydrolase with the TIM-barrel fold
STH1238	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
STH1239	COG0747	negative chemotaxis
STH1241	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
STH1242	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
STH1243	COG0564	pseudouridine synthase activity
STH1244	COG0284	orotidine-5'-phosphate decarboxylase activity
STH1247	COG3716	PTS system mannose fructose sorbose family IID component
STH1249	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
STH125	COG0653	protein targeting
STH1252	COG2222	sugar isomerase
STH1253	COG1960	acyl-CoA dehydrogenase activity
STH1256	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
STH1257	COG0540	Belongs to the ATCase OTCase family
STH1258	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
STH1259	COG0543	2 iron, 2 sulfur cluster binding
STH126	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STH1260	COG0167	dihydroorotate dehydrogenase activity
STH1261	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
STH1265	COG0393	Putative heavy-metal-binding
STH1269	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
STH127	COG0471	metal ion transport
STH1270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
STH1271	COG0724	RNA recognition motif
STH1275	COG3933	PFAM sigma-54 factor interaction domain-containing protein
STH1275	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
STH1276	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
STH1276	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
STH1277	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
STH1278	COG3716	PTS system mannose fructose sorbose family IID component
STH1280	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
STH1283	COG1120	ATPase activity
STH1284	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
STH1285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
STH1296	COG4584	PFAM Integrase catalytic
STH1297	COG4584	PFAM Integrase catalytic
STH1299	COG1484	DNA-dependent DNA replication
STH13	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
STH130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH1307	COG0210	DNA helicase
STH1310	COG0270	DNA (cytosine-5-)-methyltransferase activity
STH1311	COG1653	transport
STH1312	COG1175	transmembrane transport
STH1313	COG0395	ABC-type sugar transport system, permease component
STH1315	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
STH1316	COG1013	pyruvate-flavodoxin oxidoreductase activity
STH1317	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
STH1317	COG0674	pyruvate-flavodoxin oxidoreductase activity
STH132	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
STH1326	COG0501	Belongs to the peptidase M48B family
STH133	COG0490	domain, Protein
STH1330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
STH1335	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
STH1337	COG1561	YicC-like family, N-terminal region
STH1338	COG2052	Domain of unknown function (DUF370)
STH1339	COG0194	GDP metabolic process
STH134	COG0475	glutathione-regulated potassium exporter activity
STH1340	COG1758	RNA polymerase activity
STH1341	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
STH1342	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
STH1343	COG0242	peptide deformylase activity
STH1344	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
STH1345	COG2738	Putative neutral zinc metallopeptidase
STH1346	COG3344	reverse transcriptase
STH1349	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
STH1349	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
STH1351	COG0820	rRNA (adenine-C2-)-methyltransferase activity
STH1352	COG0631	protein serine/threonine phosphatase activity
STH1353	COG2815	serine threonine protein kinase
STH1353	COG0515	serine threonine protein kinase
STH1354	COG1162	GTPase activity
STH1355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
STH1356	COG0835	chemotaxis
STH1358	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
STH1359	COG0227	Belongs to the bacterial ribosomal protein bL28 family
STH136	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
STH1360	COG1302	Protein conserved in bacteria
STH1361	COG1461	Dihydroxyacetone kinase
STH1362	COG1216	Glycosyl transferase, family 2
STH1363	COG0438	transferase activity, transferring glycosyl groups
STH1365	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
STH1367	COG0438	transferase activity, transferring glycosyl groups
STH1369	COG1088	dTDP-glucose 4,6-dehydratase activity
STH1373	COG0438	transferase activity, transferring glycosyl groups
STH1376	COG0438	transferase activity, transferring glycosyl groups
STH1384	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
STH1386	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STH1388	COG2391	methyltransferase activity
STH1389	COG0425	Belongs to the sulfur carrier protein TusA family
STH139	COG2884	Cell division ATP-binding protein ftsE
STH1390	COG0693	protein deglycase activity
STH1391	COG1970	mechanosensitive ion channel activity
STH1392	COG2267	carboxylic ester hydrolase activity
STH14	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
STH140	COG2177	Part of the ABC transporter FtsEX involved in
STH1403	COG0561	phosphatase activity
STH1404	COG1268	BioY protein
STH1406	COG2814	Major facilitator Superfamily
STH1409	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
STH141	COG0741	lytic transglycosylase activity
STH141	COG0739	heme binding
STH141	COG1196	nuclear chromosome segregation
STH1410	COG1408	metallophosphoesterase
STH1411	COG0180	Tryptophanyl-tRNA synthetase
STH1412	COG0134	indole-3-glycerol-phosphate synthase activity
STH1413	COG0135	phosphoribosylanthranilate isomerase activity
STH1414	COG0133	tryptophan synthase activity
STH1415	COG0159	tryptophan synthase activity
STH1417	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
STH1418	COG0287	Prephenate dehydrogenase
STH1419	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
STH142	COG0793	Belongs to the peptidase S41A family
STH142	COG3409	Peptidoglycan-binding domain 1 protein
STH1421	COG0840	transmembrane signaling receptor activity
STH1421	COG0840	transmembrane signaling receptor activity
STH1422	COG0747	negative chemotaxis
STH1424	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH1425	COG0673	inositol 2-dehydrogenase activity
STH1426	COG1132	(ABC) transporter
STH1433	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
STH1437	COG3584	3D domain protein
STH1437	COG1388	LysM domain
STH1438	COG0742	ribosomal rna small subunit methyltransferase
STH1439	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
STH1441	COG3480	Lon protease (S16) C-terminal proteolytic domain
STH1443	COG0333	Belongs to the bacterial ribosomal protein bL32 family
STH1444	COG0454	-acetyltransferase
STH1446	COG2030	dehydratase
STH1447	COG0416	fatty acid biosynthetic process
STH1448	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
STH1449	COG1307	EDD domain protein, DegV family
STH145	COG0601	transmembrane transport
STH1450	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
STH1451	COG1028	Short-chain dehydrogenase reductase Sdr
STH1452	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
STH1453	COG0571	ribonuclease III activity
STH1454	COG2359	stage V sporulation protein S
STH1455	COG1196	nuclear chromosome segregation
STH1457	COG0552	protein localization to endoplasmic reticulum
STH1458	COG0789	Transcriptional regulator
STH146	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH1463	COG1694	Mazg nucleotide pyrophosphohydrolase
STH1464	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
STH1465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
STH1466	COG0228	four-way junction DNA binding
STH1467	COG1837	Belongs to the UPF0109 family
STH1469	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
STH1470	COG0336	Belongs to the RNA methyltransferase TrmD family
STH1471	COG0335	large ribosomal subunit rRNA binding
STH1474	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
STH1475	COG0792	nuclease activity
STH148	COG0601	transmembrane transport
STH1480	COG0758	DNA mediated transformation
STH1480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
STH1481	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
STH1482	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
STH1483	COG4974	Belongs to the 'phage' integrase family
STH1484	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
STH149	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH1491	COG0052	Belongs to the universal ribosomal protein uS2 family
STH1492	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
STH1493	COG0528	UMP kinase activity
STH1494	COG0233	cytoplasmic translational termination
STH1497	COG4589	Belongs to the CDS family
STH1498	COG0628	permease
STH1499	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
STH15	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
STH150	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
STH1500	COG0750	zinc metalloprotease
STH1501	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
STH1502	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
STH1504	COG1752	Esterase of the alpha-beta hydrolase superfamily
STH1506	COG0803	Belongs to the bacterial solute-binding protein 9 family
STH1507	COG1121	(ABC) transporter
STH1508	COG1321	iron dependent repressor
STH1508	COG1108	ABC-type Mn2 Zn2 transport systems permease components
STH1509	COG1108	ABC-type Mn2 Zn2 transport systems permease components
STH151	COG0556	nucleotide-excision repair
STH1510	COG1215	transferase activity, transferring glycosyl groups
STH1511	COG1285	pathogenesis
STH1512	COG2176	DNA-directed DNA polymerase activity
STH1514	COG0561	phosphatase activity
STH1518	COG0779	Required for maturation of 30S ribosomal subunits
STH1519	COG0195	Participates in both transcription termination and antitermination
STH1520	COG2740	Nucleic-acid-binding protein implicated in transcription termination
STH1521	COG1358	cellular component organization or biogenesis
STH1522	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
STH1523	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
STH1524	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
STH1525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
STH1526	COG0196	riboflavin kinase activity
STH1527	COG1187	pseudouridine synthase activity
STH1528	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
STH1529	COG1595	DNA-templated transcription, initiation
STH1531	COG1185	polyribonucleotide nucleotidyltransferase activity
STH1532	COG0612	Peptidase, M16
STH1533	COG0756	dUTP diphosphatase activity
STH1535	COG0835	chemotaxis
STH1536	COG0835	chemotaxis
STH1537	COG2198	Histidine kinase
STH1537	COG0643	Histidine kinase
STH1539	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
STH154	COG2816	NAD+ diphosphatase activity
STH1540	COG2201	protein-glutamate methylesterase activity
STH1541	COG2201	protein-glutamate methylesterase activity
STH1542	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
STH1544	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
STH1545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
STH1546	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
STH1547	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
STH1548	COG0527	aspartate kinase activity
STH1549	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
STH1550	COG3344	reverse transcriptase
STH1551	COG3344	reverse transcriptase
STH1556	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
STH1558	COG0740	serine-type endopeptidase activity
STH156	COG0351	phosphomethylpyrimidine kinase
STH1560	COG0735	belongs to the Fur family
STH1564	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
STH1565	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
STH157	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
STH157	COG0352	thiamine-phosphate diphosphorylase activity
STH1571	COG1960	acyl-CoA dehydrogenase activity
STH1572	COG0511	ligase activity, forming carbon-carbon bonds
STH1577	COG1024	Enoyl-CoA hydratase
STH1579	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
STH1582	COG0017	Asparaginyl-tRNA synthetase
STH1585	COG1686	Belongs to the peptidase S11 family
STH1586	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STH1587	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STH1588	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STH1589	COG0649	NAD binding
STH159	COG0318	PFAM AMP-dependent synthetase and ligase
STH1591	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
STH1592	COG1034	ATP synthesis coupled electron transport
STH1593	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
STH1594	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STH1595	COG0839	Belongs to the complex I subunit 6 family
STH1596	COG0713	ATP synthesis coupled electron transport
STH1597	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
STH1598	COG1007	ATP synthesis coupled electron transport
STH16	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
STH1600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
STH1600	COG2207	Transcriptional regulator
STH1601	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
STH1602	COG4605	iron ion homeostasis
STH1603	COG4604	ABC transporter, ATP-binding protein
STH1604	COG4607	ABC-type enterochelin transport system periplasmic component
STH161	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
STH1610	COG2195	Cleaves the N-terminal amino acid of tripeptides
STH1613	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
STH1615	COG0559	Belongs to the binding-protein-dependent transport system permease family
STH1616	COG0559	Belongs to the binding-protein-dependent transport system permease family
STH1617	COG0411	ABC transporter
STH1619	COG0535	radical SAM domain protein
STH162	COG1073	alpha beta
STH1623	COG1205	dead DEAH box helicase
STH1623	COG1111	helicase
STH1624	COG0438	transferase activity, transferring glycosyl groups
STH1625	COG2217	Heavy metal translocating P-type atpase
STH1629	COG1131	(ABC) transporter
STH1633	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STH1634	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
STH1638	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STH1642	COG0697	spore germination
STH1643	COG1546	Belongs to the CinA family
STH1643	COG1058	Belongs to the CinA family
STH1644	COG1940	carbohydrate kinase activity
STH1646	COG1803	Methylglyoxal synthase
STH1647	COG0513	Belongs to the DEAD box helicase family
STH165	COG1733	regulation of RNA biosynthetic process
STH1652	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
STH1655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
STH1655	COG2111	Na H antiporter
STH1656	COG2111	Na H antiporter
STH1657	COG1006	Multisubunit Na H antiporter MnhC subunit
STH1659	COG1863	multisubunit Na H antiporter MnhE subunit
STH1660	COG2212	antiporter activity
STH1665	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
STH1666	COG2137	regulation of response to DNA damage stimulus
STH1668	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
STH167	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
STH1671	COG3344	reverse transcriptase
STH1673	COG3875	lactate racemase activity
STH1674	COG1304	FMN binding
STH1679	COG1160	GTP binding
STH1680	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
STH1681	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
STH1684	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
STH1685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
STH1688	COG3069	C4-dicarboxylate transmembrane transporter activity
STH1689	COG2195	Cleaves the N-terminal amino acid of tripeptides
STH1691	COG1294	oxidase, subunit
STH1692	COG1271	oxidase subunit
STH1694	COG0105	UTP biosynthetic process
STH1695	COG4942	peptidase
STH1696	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
STH1697	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
STH1699	COG5002	protein histidine kinase activity
STH1699	COG5001	Diguanylate cyclase
STH1703	COG0402	S-adenosylhomocysteine deaminase activity
STH1704	COG1131	(ABC) transporter
STH1707	COG0667	Aldo Keto reductase
STH171	COG0322	excinuclease ABC activity
STH1710	COG3679	Belongs to the UPF0342 family
STH1711	COG2045	Belongs to the ComB family
STH1713	COG1199	ATP-dependent helicase activity
STH1713	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
STH1714	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
STH1715	COG0688	phosphatidylethanolamine metabolic process
STH1716	COG1183	phosphatidylcholine synthase activity
STH173	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STH1730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
STH1731	COG1333	cytochrome c biogenesis protein
STH1732	COG0785	Cytochrome C biogenesis protein
STH1733	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STH1736	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
STH1738	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
STH1741	COG1595	DNA-templated transcription, initiation
STH1743	COG1131	(ABC) transporter
STH1744	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
STH1745	COG0464	growth
STH1746	COG1923	regulation of RNA biosynthetic process
STH1747	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
STH1748	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
STH1755	COG3344	reverse transcriptase
STH1757	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
STH1759	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STH1761	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
STH1761	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
STH1765	COG0724	RNA recognition motif
STH1767	COG0583	DNA-binding transcription factor activity
STH177	COG1950	PFAM Membrane protein of
STH1770	COG0714	Associated with various cellular activities
STH1773	COG0613	PHP domain protein
STH1774	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
STH1776	COG2359	stage V sporulation protein S
STH1777	COG1692	metallophosphoesterase
STH1779	COG1418	mRNA catabolic process
STH1782	COG3842	ATPase activity
STH1783	COG1187	pseudouridine synthase activity
STH1786	COG0700	Nucleoside recognition
STH1787	COG2715	membrane protein required for spore maturation
STH1788	COG3870	Protein conserved in bacteria
STH1789	COG0726	polysaccharide deacetylase
STH1790	COG3858	chitin binding
STH1794	COG3344	reverse transcriptase
STH1798	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
STH1799	COG3874	Sporulation protein YtfJ
STH18	COG0010	Belongs to the arginase family
STH1802	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
STH1803	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
STH1804	COG1994	Peptidase M50
STH1806	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
STH1807	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
STH1808	COG1136	(ABC) transporter
STH1808	COG0577	efflux transmembrane transporter activity
STH1810	COG0019	diaminopimelate decarboxylase activity
STH1815	COG1686	Belongs to the peptidase S11 family
STH1816	COG1131	(ABC) transporter
STH1820	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
STH1821	COG4974	Belongs to the 'phage' integrase family
STH1824	COG1379	DNA repair
STH1825	COG0494	nUDIX hydrolase
STH1826	COG3426	butyrate kinase activity
STH1828	COG0280	phosphate acetyltransferase
STH1831	COG3290	protein histidine kinase activity
STH1831	COG3829	transcription factor binding
STH1832	COG0745	RESPONSE REGULATOR receiver
STH1833	COG0750	zinc metalloprotease
STH1835	COG0497	DNA recombination
STH1836	COG1438	arginine binding
STH1837	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
STH1841	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
STH1842	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
STH1844	COG0142	geranyltranstransferase activity
STH1845	COG1722	exodeoxyribonuclease VII activity
STH1847	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
STH1848	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
STH1849	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
STH1852	COG1302	Protein conserved in bacteria
STH186	COG1660	Displays ATPase and GTPase activities
STH1862	COG3854	ATPases associated with a variety of cellular activities
STH1864	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
STH1865	COG0006	proline dipeptidase activity
STH1866	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
STH1868	COG0705	Rhomboid family
STH1868	COG0457	Tetratricopeptide repeat
STH187	COG0391	Required for morphogenesis under gluconeogenic growth conditions
STH1872	COG0156	8-amino-7-oxononanoate synthase activity
STH1873	COG1063	alcohol dehydrogenase
STH1879	COG1108	ABC-type Mn2 Zn2 transport systems permease components
STH1880	COG1121	(ABC) transporter
STH1882	COG0735	belongs to the Fur family
STH1883	COG1316	TRANSCRIPTIONal
STH1884	COG3012	SEC-C Motif Domain Protein
STH1885	COG0587	DNA-directed DNA polymerase activity
STH189	COG1481	regulation of sporulation
STH1891	COG0564	pseudouridine synthase activity
STH1892	COG0517	IMP dehydrogenase activity
STH1894	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
STH19	COG0018	arginyl-trna synthetase
STH1900	COG3191	aminopeptidase activity
STH1901	COG4684	Psort location CytoplasmicMembrane, score
STH1903	COG0346	lactoylglutathione lyase activity
STH1904	COG2226	methyltransferase
STH1908	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
STH1909	COG0732	type I restriction modification DNA specificity domain
STH191	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
STH1910	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
STH1912	COG1228	amidohydrolase
STH1913	COG0402	S-adenosylhomocysteine deaminase activity
STH1917	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
STH1918	COG0095	Lipoate-protein ligase
STH1919	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
STH192	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
STH1920	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
STH1921	COG0509	glycine decarboxylation via glycine cleavage system
STH1922	COG0404	The glycine cleavage system catalyzes the degradation of glycine
STH1925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
STH1926	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
STH1929	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
STH1932	COG1492	cobalamin metabolic process
STH1933	COG1120	ATPase activity
STH1934	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
STH1936	COG4821	SIS domain
STH194	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
STH1941	COG3716	PTS system mannose fructose sorbose family IID component
STH1946	COG0473	3-isopropylmalate dehydrogenase activity
STH1947	COG2313	pseudouridylate synthase activity
STH1948	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
STH1949	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
STH1950	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
STH1952	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
STH1953	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
STH1956	COG0601	transmembrane transport
STH1958	COG1191	sigma factor activity
STH196	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
STH1960	COG1131	(ABC) transporter
STH1969	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
STH1970	COG1116	anion transmembrane transporter activity
STH1971	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
STH1972	COG1674	ftsk spoiiie
STH1974	COG1132	(ABC) transporter
STH1975	COG1132	(ABC) transporter
STH1977	COG0330	HflC and HflK could
STH1979	COG1573	uracil-dna glycosylase
STH1980	COG3344	reverse transcriptase
STH1982	COG3858	chitin binding
STH1982	COG1388	LysM domain
STH1983	COG1482	cell wall glycoprotein biosynthetic process
STH1984	COG0247	lactate metabolic process
STH1986	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
STH1988	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
STH1991	COG0768	penicillin binding
STH1992	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
STH1993	COG3906	Belongs to the UPF0473 family
STH1994	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
STH1998	COG4472	Bacterial protein of unknown function (DUF965)
STH2	COG0592	DNA-directed DNA polymerase activity
STH20	COG3344	reverse transcriptase
STH2000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
STH2002	COG1191	sigma factor activity
STH2006	COG5002	protein histidine kinase activity
STH2007	COG0745	RESPONSE REGULATOR receiver
STH201	COG5566	PFAM Mor transcription activator
STH2012	COG2814	Major facilitator Superfamily
STH2014	COG3344	reverse transcriptase
STH2023	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
STH2026	COG2816	NAD+ diphosphatase activity
STH2029	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
STH203	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
STH2030	COG2949	membrane
STH2034	COG0396	ATPase activity
STH2035	COG0719	Fe-S assembly protein
STH2036	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
STH2037	COG0822	iron-sulfur transferase activity
STH2038	COG0719	Fe-S assembly protein
STH2039	COG2146	nitrite reductase [NAD(P)H] activity
STH2040	COG2151	metal-sulfur cluster biosynthetic enzyme
STH2043	COG1595	DNA-templated transcription, initiation
STH2046	COG0745	RESPONSE REGULATOR receiver
STH205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
STH2055	COG0437	4 iron, 4 sulfur cluster binding
STH2056	COG0243	molybdopterin cofactor binding
STH2057	COG3344	reverse transcriptase
STH2061	COG4810	utilization protein
STH2063	COG4303	Ethanolamine ammonia lyase large subunit
STH2066	COG0477	Major facilitator Superfamily
STH2068	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
STH2072	COG3708	Transcriptional regulator
STH2072	COG2207	Transcriptional regulator
STH2075	COG1131	(ABC) transporter
STH2076	COG1695	Transcriptional regulator
STH2077	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
STH208	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
STH2088	COG5002	protein histidine kinase activity
STH2093	COG0109	protoheme IX farnesyltransferase activity
STH2094	COG1999	signal sequence binding
STH2097	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
STH21	COG0659	secondary active sulfate transmembrane transporter activity
STH2100	COG3336	cytochrome c oxidase
STH2105	COG0531	amino acid
STH2106	COG0697	spore germination
STH2107	COG1668	transmembrane transport
STH2108	COG1131	(ABC) transporter
STH2115	COG0066	3-isopropylmalate dehydratase activity
STH2116	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
STH2117	COG0583	DNA-binding transcription factor activity
STH2123	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
STH2127	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
STH213	COG1024	Enoyl-CoA hydratase
STH2131	COG0768	penicillin binding
STH2133	COG1739	Uncharacterized protein family UPF0029
STH2135	COG3706	GGDEF domain
STH2137	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
STH2139	COG4585	Histidine kinase
STH214	COG1250	3-hydroxyacyl-CoA dehydrogenase
STH2140	COG2197	response regulator
STH2141	COG0586	Pfam SNARE associated Golgi protein
STH2149	COG0640	Transcriptional regulator
STH2150	COG0494	nUDIX hydrolase
STH2153	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
STH2157	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
STH2158	COG1122	ATPase activity
STH2159	COG1122	ATPase activity
STH2160	COG0508	dehydrogenase complex catalyzes the overall conversion of
STH2161	COG0022	dehydrogenase e1 component
STH2162	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
STH2163	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
STH2164	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
STH2168	COG0726	polysaccharide deacetylase
STH2172	COG0569	domain protein
STH2172	COG2985	domain, Protein
STH2173	COG1074	ATP-dependent DNA helicase activity
STH2174	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
STH2175	COG0419	ATPase involved in DNA repair
STH2176	COG0420	3'-5' exonuclease activity
STH2179	COG1653	transport
STH218	COG1131	(ABC) transporter
STH2182	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
STH2184	COG0789	Transcriptional regulator
STH2185	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
STH2187	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STH2189	COG1309	transcriptional regulator
STH2190	COG0318	PFAM AMP-dependent synthetase and ligase
STH2191	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
STH2193	COG0411	ABC transporter
STH2195	COG0559	Belongs to the binding-protein-dependent transport system permease family
STH2197	COG3693	PFAM glycoside hydrolase, family 10
STH2198	COG1752	Esterase of the alpha-beta hydrolase superfamily
STH22	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
STH2206	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
STH2206	COG3608	succinylglutamate desuccinylase aspartoacylase
STH2208	COG2814	Major facilitator Superfamily
STH2222	COG2391	methyltransferase activity
STH2231	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
STH2232	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
STH2235	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
STH2236	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
STH2237	COG3344	reverse transcriptase
STH2246	COG3328	transposase activity
STH225	COG0745	RESPONSE REGULATOR receiver
STH2250	COG1131	(ABC) transporter
STH2255	COG1309	transcriptional regulator
STH2261	COG2189	Belongs to the N(4) N(6)-methyltransferase family
STH2266	COG3267	Type II secretory pathway component ExeA
STH2266	COG3409	Peptidoglycan-binding domain 1 protein
STH2279	COG3328	transposase activity
STH2280	COG3344	reverse transcriptase
STH2281	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
STH2287	COG1484	DNA-dependent DNA replication
STH229	COG0004	ammonium transporteR
STH2293	COG1111	helicase
STH2293	COG1205	dead DEAH box helicase
STH2294	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
STH2297	COG2391	methyltransferase activity
STH2298	COG1349	DNA-binding transcription factor activity
STH2299	COG3395	kinase activity
STH230	COG0067	glutamate synthase
STH230	COG0070	glutamate synthase
STH230	COG0069	glutamate synthase activity
STH2300	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
STH2301	COG2610	gluconate transmembrane transporter activity
STH2303	COG1028	Short-chain dehydrogenase reductase Sdr
STH2305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
STH2308	COG3037	sugar-specific permease SgaT UlaA
STH231	COG0367	asparagine synthase
STH2310	COG3958	Transketolase
STH2311	COG3959	Transketolase, thiamine diphosphate binding domain
STH2312	COG3711	transcriptional antiterminator
STH2312	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
STH2315	COG0747	negative chemotaxis
STH2316	COG2378	regulation of single-species biofilm formation
STH2319	COG3214	Protein conserved in bacteria
STH2321	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STH2322	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
STH2325	COG1234	tRNA 3'-trailer cleavage
STH2326	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
STH2332	COG0243	molybdopterin cofactor binding
STH2336	COG1309	transcriptional regulator
STH2337	COG0698	ribose 5-phosphate isomerase
STH2339	COG1940	carbohydrate kinase activity
STH2340	COG1172	Belongs to the binding-protein-dependent transport system permease family
STH2341	COG1129	ABC transporter
STH2342	COG1879	ABC-type sugar transport system periplasmic component
STH2343	COG1609	Transcriptional regulator
STH2344	COG0473	3-isopropylmalate dehydrogenase activity
STH2349	COG1605	Chorismate mutase
STH2349	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
STH2350	COG1649	PFAM Uncharacterised BCR, COG1649
STH2350	COG0726	polysaccharide deacetylase
STH2352	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
STH2353	COG2197	response regulator
STH2355	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
STH2357	COG1960	acyl-CoA dehydrogenase activity
STH2360	COG0559	Belongs to the binding-protein-dependent transport system permease family
STH2362	COG0626	cystathionine gamma-synthase activity
STH2363	COG0626	cystathionine gamma-synthase activity
STH2366	COG1051	belongs to the nudix hydrolase family
STH2367	COG0546	phosphoglycolate phosphatase activity
STH2369	COG2226	methyltransferase
STH237	COG0573	inorganic phosphate transmembrane transporter activity
STH2370	COG0640	Transcriptional regulator
STH2375	COG1686	Belongs to the peptidase S11 family
STH238	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
STH2385	COG0628	permease
STH2389	COG0482	sulfurtransferase activity
STH239	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
STH2391	COG1959	2 iron, 2 sulfur cluster binding
STH2392	COG0768	penicillin binding
STH2394	COG0589	response to stress
STH2398	COG5002	protein histidine kinase activity
STH2402	COG0116	Belongs to the methyltransferase superfamily
STH2408	COG0537	adenosine 5'-monophosphoramidase activity
STH2415	COG1819	glycosyl
STH2416	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
STH2419	COG0456	acetyltransferase
STH242	COG0126	phosphoglycerate kinase activity
STH2420	COG0456	acetyltransferase
STH2421	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
STH2422	COG0124	histidyl-tRNA synthetase
STH2423	COG3340	Belongs to the peptidase S51 family
STH2424	COG1597	lipid kinase activity
STH2425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
STH2427	COG1846	Transcriptional regulator
STH2428	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STH2430	COG1490	D-aminoacyl-tRNA deacylase activity
STH2435	COG1164	Oligoendopeptidase f
STH2437	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
STH2438	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
STH2439	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
STH2439	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
STH244	COG0149	triose-phosphate isomerase activity
STH2442	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
STH2443	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
STH2448	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
STH2448	COG1263	PTS System
STH2449	COG3394	polysaccharide catabolic process
STH245	COG1937	Protein conserved in bacteria
STH2450	COG1486	melibiose metabolic process
STH2452	COG0697	spore germination
STH2456	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
STH2457	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
STH2458	COG0584	glycerophosphoryl diester phosphodiesterase
STH2459	COG0583	DNA-binding transcription factor activity
STH2460	COG0494	nUDIX hydrolase
STH2463	COG1960	acyl-CoA dehydrogenase activity
STH2465	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STH2465	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STH2470	COG0456	acetyltransferase
STH2477	COG1960	acyl-CoA dehydrogenase activity
STH2478	COG0704	Plays a role in the regulation of phosphate uptake
STH248	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
STH2483	COG2151	metal-sulfur cluster biosynthetic enzyme
STH2486	COG3396	Phenylacetate-CoA oxygenase
STH2489	COG2610	gluconate transmembrane transporter activity
STH249	COG0148	phosphopyruvate hydratase activity
STH2490	COG1929	Belongs to the glycerate kinase type-1 family
STH2491	COG3835	regulator
STH2492	COG2340	Cysteine-rich secretory protein family
STH2495	COG1968	undecaprenyl-diphosphatase activity
STH2498	COG1472	Belongs to the glycosyl hydrolase 3 family
STH2499	COG2871	sodium ion transport
STH25	COG2197	response regulator
STH250	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
STH2500	COG1410	methionine synthase
STH2500	COG0646	methionine synthase
STH2502	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
STH2502	COG0646	methionine synthase
STH2503	COG0739	heme binding
STH2508	COG0667	Aldo Keto reductase
STH2513	COG0492	ferredoxin-NADP+ reductase activity
STH2515	COG2226	methyltransferase
STH2516	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
STH2522	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
STH2526	COG4869	propanediol catabolic process
STH253	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
STH2532	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
STH2533	COG0045	succinate-CoA ligase (ADP-forming) activity
STH2534	COG0281	malic enzyme
STH2536	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
STH2539	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
STH254	COG2011	ABC-type metal ion transport system permease component
STH2540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
STH2541	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STH2543	COG0039	L-malate dehydrogenase activity
STH2544	COG0538	isocitrate dehydrogenase activity
STH2546	COG2226	methyltransferase
STH255	COG1464	Belongs to the NlpA lipoprotein family
STH2550	COG1937	Protein conserved in bacteria
STH2551	COG4347	Protein of unknown function (DUF1405)
STH2552	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STH2553	COG0714	Associated with various cellular activities
STH2555	COG1305	Transglutaminase-like
STH2556	COG0083	homoserine kinase activity
STH2557	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
STH2558	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
STH2559	COG3344	reverse transcriptase
STH2562	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
STH2574	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
STH2575	COG0024	Methionine aminopeptidase
STH2577	COG1132	(ABC) transporter
STH2584	COG1250	3-hydroxyacyl-CoA dehydrogenase
STH2585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
STH2587	COG1686	Belongs to the peptidase S11 family
STH2589	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
STH259	COG0367	asparagine synthase
STH2591	COG1921	L-seryl-tRNASec selenium transferase activity
STH2593	COG5632	N-Acetylmuramoyl-L-alanine amidase
STH2593	COG3409	Peptidoglycan-binding domain 1 protein
STH2595	COG2223	nitrite transmembrane transporter activity
STH2597	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
STH2599	COG5557	Pfam Polysulphide reductase, NrfD
STH2600	COG3064	Membrane
STH2600	COG0437	4 iron, 4 sulfur cluster binding
STH2602	COG3383	formate dehydrogenase (NAD+) activity
STH2602	COG0243	molybdopterin cofactor binding
STH2604	COG0583	DNA-binding transcription factor activity
STH2605	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
STH2609	COG4152	abc transporter atp-binding protein
STH261	COG3314	Sporulation integral membrane protein YlbJ
STH2611	COG0488	(ABC) transporter
STH2616	COG2217	Heavy metal translocating P-type atpase
STH2618	COG1612	heme a metabolic process
STH2621	COG1126	abc transporter atp-binding protein
STH2622	COG0765	amino acid transport
STH2623	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
STH2625	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
STH2626	COG0668	transmembrane transport
STH2627	COG1732	Glycine betaine
STH2628	COG1174	glycine betaine transport
STH2630	COG0517	IMP dehydrogenase activity
STH2630	COG1125	glycine betaine transport
STH2632	COG0577	efflux transmembrane transporter activity
STH2632	COG0577	efflux transmembrane transporter activity
STH2633	COG1136	(ABC) transporter
STH2634	COG4585	Histidine kinase
STH2635	COG2197	response regulator
STH2636	COG0471	metal ion transport
STH2637	COG2009	succinate dehydrogenase
STH2638	COG2009	succinate dehydrogenase
STH2640	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
STH2641	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
STH2643	COG1809	phosphosulfolactate synthase activity
STH2647	COG2814	Major facilitator Superfamily
STH2648	COG2707	UPF0756 membrane protein
STH2651	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
STH2653	COG0601	transmembrane transport
STH2658	COG0519	Catalyzes the synthesis of GMP from XMP
STH2660	COG0010	Belongs to the arginase family
STH2662	COG2843	Capsule synthesis protein
STH2664	COG4555	ABC transporter
STH2667	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
STH2668	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
STH2670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
STH2675	COG1363	Peptidase, m42
STH2679	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
STH2679	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
STH2680	COG1832	CoA-binding protein
STH2682	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
STH2684	COG0028	Belongs to the TPP enzyme family
STH2685	COG0129	dihydroxy-acid dehydratase activity
STH2686	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
STH2687	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
STH2688	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
STH2692	COG1605	Chorismate mutase
STH2692	COG0077	Prephenate dehydratase
STH2693	COG1846	Transcriptional regulator
STH2697	COG0673	inositol 2-dehydrogenase activity
STH2698	COG1484	DNA-dependent DNA replication
STH27	COG1765	OsmC-like protein
STH2701	COG4584	PFAM Integrase catalytic
STH2702	COG1484	DNA-dependent DNA replication
STH2705	COG3328	transposase activity
STH2707	COG0438	transferase activity, transferring glycosyl groups
STH2711	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
STH2712	COG0438	transferase activity, transferring glycosyl groups
STH2713	COG1210	Utp--glucose-1-phosphate uridylyltransferase
STH2715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
STH2719	COG3267	Type II secretory pathway component ExeA
STH2719	COG3409	Peptidoglycan-binding domain 1 protein
STH272	COG4584	PFAM Integrase catalytic
STH2723	COG1132	(ABC) transporter
STH2724	COG1132	(ABC) transporter
STH2726	COG3344	reverse transcriptase
STH2728	COG2197	response regulator
STH2729	COG4585	Histidine kinase
STH273	COG1484	DNA-dependent DNA replication
STH2731	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
STH2732	COG3344	reverse transcriptase
STH2734	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
STH2736	COG1705	Flagellar rod assembly protein muramidase FlgJ
STH2736	COG3951	Flagellar rod assembly protein muramidase FlgJ
STH2737	COG0584	glycerophosphoryl diester phosphodiesterase
STH2738	COG1279	arginine transmembrane transporter activity
STH2739	COG0460	homoserine dehydrogenase
STH274	COG1484	DNA-dependent DNA replication
STH2740	COG1199	ATP-dependent helicase activity
STH2741	COG1012	belongs to the aldehyde dehydrogenase family
STH2743	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH2744	COG0601	transmembrane transport
STH2750	COG0165	Argininosuccinate lyase
STH2751	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
STH2752	COG3842	ATPase activity
STH2753	COG1940	carbohydrate kinase activity
STH2754	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
STH2761	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
STH2762	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
STH2766	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
STH2767	COG1007	ATP synthesis coupled electron transport
STH2769	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
STH2770	COG0713	ATP synthesis coupled electron transport
STH2772	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STH2773	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
STH2774	COG0649	NAD binding
STH2775	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STH2776	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STH2777	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STH2786	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
STH2787	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
STH2790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
STH2792	COG0616	signal peptide processing
STH2795	COG1595	DNA-templated transcription, initiation
STH2797	COG2267	carboxylic ester hydrolase activity
STH2798	COG2211	Major facilitator Superfamily
STH28	COG1595	DNA-templated transcription, initiation
STH2805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
STH2807	COG0662	Cupin 2, conserved barrel domain protein
STH2808	COG1619	proteins homologs of microcin C7 resistance protein MccF
STH2810	COG2226	methyltransferase
STH2812	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
STH2817	COG1215	transferase activity, transferring glycosyl groups
STH2818	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
STH2819	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
STH2820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
STH2821	COG0154	amidase activity
STH2822	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
STH2823	COG4608	Belongs to the ABC transporter superfamily
STH2824	COG0444	Belongs to the ABC transporter superfamily
STH2825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
STH2827	COG0741	lytic transglycosylase activity
STH2830	COG2373	Large extracellular alpha-helical protein
STH2831	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
STH2832	COG0140	phosphoribosyl-ATP diphosphatase activity
STH2832	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
STH2833	COG0107	imidazoleglycerol-phosphate synthase activity
STH2834	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
STH2835	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
STH2836	COG0131	Imidazoleglycerol-phosphate dehydratase
STH2837	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
STH2838	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
STH2839	COG0124	histidyl-tRNA synthetase
STH2840	COG0724	RNA recognition motif
STH2841	COG0569	domain protein
STH2841	COG0475	glutathione-regulated potassium exporter activity
STH2842	COG3033	Beta-eliminating lyase
STH2844	COG4496	protein, YerC YecD
STH2847	COG2267	carboxylic ester hydrolase activity
STH2848	COG5001	Diguanylate cyclase
STH2848	COG5002	protein histidine kinase activity
STH2849	COG0151	Belongs to the GarS family
STH2850	COG0138	bifunctional purine biosynthesis protein purh
STH2852	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
STH2853	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
STH2854	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
STH2855	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
STH2856	COG0047	phosphoribosylformylglycinamidine synthase activity
STH2857	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
STH2860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
STH2861	COG2252	PERMEase
STH2862	COG0351	phosphomethylpyrimidine kinase
STH2871	COG3118	belongs to the thioredoxin family
STH2874	COG0137	argininosuccinate synthase activity
STH2875	COG2217	Heavy metal translocating P-type atpase
STH2879	COG2268	Band 7 protein
STH2881	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
STH2882	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
STH2884	COG1051	belongs to the nudix hydrolase family
STH2885	COG3284	Transcriptional regulator
STH2886	COG2414	aldehyde ferredoxin oxidoreductase
STH2889	COG3706	GGDEF domain
STH2890	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
STH2891	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
STH2892	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
STH2896	COG0546	phosphoglycolate phosphatase activity
STH2897	COG0459	protein refolding
STH2898	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
STH2899	COG1796	DNA polymerase
STH2899	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
STH2903	COG0315	cyclic pyranopterin monophosphate synthase activity
STH2904	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
STH2906	COG0303	'Molybdopterin
STH291	COG4447	cellulose binding
STH2911	COG3226	Transcriptional regulator
STH2912	COG1250	3-hydroxyacyl-CoA dehydrogenase
STH2913	COG0183	Belongs to the thiolase family
STH2914	COG0772	Belongs to the SEDS family
STH2915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
STH2916	COG0517	IMP dehydrogenase activity
STH2916	COG0516	GMP reductase activity
STH2917	COG1573	uracil-dna glycosylase
STH2918	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
STH2919	COG0671	phosphoesterase, PA-phosphatase related
STH292	COG2971	BadF BadG BcrA BcrD
STH2920	COG0110	maltose O-acetyltransferase activity
STH2921	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
STH2922	COG0328	RNA-DNA hybrid ribonuclease activity
STH2923	COG0456	acetyltransferase
STH2924	COG3344	reverse transcriptase
STH2926	COG0802	atpase or kinase
STH2928	COG2183	response to ionizing radiation
STH2933	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
STH2934	COG2337	Toxic component of a toxin-antitoxin (TA) module
STH2936	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
STH2937	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
STH2937	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
STH2938	COG0736	holo-[acyl-carrier-protein] synthase activity
STH2943	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
STH2944	COG2151	metal-sulfur cluster biosynthetic enzyme
STH2948	COG0012	GTP binding
STH2951	COG0179	Fumarylacetoacetate (FAA) hydrolase
STH2953	COG3344	reverse transcriptase
STH2957	COG3859	Proton-coupled thiamine transporter YuaJ
STH2958	COG3409	Peptidoglycan-binding domain 1 protein
STH2958	COG3773	Cell wall hydrolase
STH2959	COG2959	enzyme of heme biosynthesis
STH296	COG4608	Belongs to the ABC transporter superfamily
STH2962	COG1595	DNA-templated transcription, initiation
STH2963	COG1056	cytidyltransferase-related domain
STH2963	COG3172	ATPase kinase involved in NAD metabolism
STH2964	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
STH2965	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
STH2966	COG0840	transmembrane signaling receptor activity
STH297	COG0444	Belongs to the ABC transporter superfamily
STH2972	COG1360	Flagellar Motor Protein
STH2973	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
STH2974	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
STH2976	COG1516	flagellar protein fliS
STH2978	COG1334	flagellar protein FlaG
STH2980	COG4786	Flagellar basal body rod
STH2980	COG1256	bacterial-type flagellum assembly
STH2984	COG1191	sigma factor activity
STH2985	COG0455	bacterial-type flagellum organization
STH2986	COG1419	protein localization to endoplasmic reticulum
STH2986	COG1419	protein localization to endoplasmic reticulum
STH2987	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
STH2988	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
STH299	COG0601	transmembrane transport
STH2990	COG1987	bacterial-type flagellum assembly
STH2991	COG1338	Plays a role in the flagellum-specific transport system
STH2996	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
STH30	COG1752	Esterase of the alpha-beta hydrolase superfamily
STH300	COG1472	Belongs to the glycosyl hydrolase 3 family
STH3000	COG1157	protein secretion by the type III secretion system
STH3002	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
STH3003	COG1766	The M ring may be actively involved in energy transduction
STH3004	COG1677	Flagellar hook-basal body complex protein FliE
STH3006	COG1815	bacterial-type flagellum-dependent cell motility
STH3007	COG4786	Flagellar basal body rod
STH301	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
STH3010	COG1960	acyl-CoA dehydrogenase activity
STH3011	COG0183	Belongs to the thiolase family
STH3012	COG1024	Enoyl-CoA hydratase
STH3012	COG1250	3-hydroxyacyl-CoA dehydrogenase
STH3013	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
STH3014	COG2086	electron transfer activity
STH3015	COG1309	transcriptional regulator
STH3016	COG0318	PFAM AMP-dependent synthetase and ligase
STH3019	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
STH302	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
STH3022	COG4120	Belongs to the binding-protein-dependent transport system permease family
STH3023	COG1116	anion transmembrane transporter activity
STH303	COG3876	Protein conserved in bacteria
STH3035	COG0473	3-isopropylmalate dehydrogenase activity
STH3037	COG2226	methyltransferase
STH3039	COG0860	N-Acetylmuramoyl-L-alanine amidase
STH3040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
STH3041	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
STH3042	COG0101	tRNA pseudouridine synthase activity
STH3043	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
STH3044	COG1122	ATPase activity
STH3045	COG1122	ATPase activity
STH3046	COG0203	ribosomal protein L17
STH3047	COG0202	RNA polymerase activity
STH3048	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
STH3049	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
STH3050	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
STH3051	COG0257	Belongs to the bacterial ribosomal protein bL36 family
STH3052	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
STH3054	COG0563	adenylate kinase activity
STH3055	COG0201	protein transport
STH3056	COG0200	Binds to the 23S rRNA
STH3057	COG1841	ribosomal large subunit assembly
STH3058	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
STH3059	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
STH3060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
STH3061	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
STH3062	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
STH3063	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
STH3064	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
STH3065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
STH3066	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
STH3067	COG0255	Belongs to the universal ribosomal protein uL29 family
STH3068	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
STH3069	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
STH3070	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
STH3071	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
STH3072	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
STH3073	COG0089	rRNA binding
STH3074	COG0088	Forms part of the polypeptide exit tunnel
STH3075	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
STH3076	COG0051	transcription antitermination factor activity, RNA binding
STH3077	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
STH3078	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
STH3079	COG0049	tRNA binding
STH308	COG3328	transposase activity
STH3080	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
STH3081	COG1358	cellular component organization or biogenesis
STH3082	COG2813	Specifically methylates the guanine in position
STH3084	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
STH3085	COG0085	RNA polymerase activity
STH3086	COG0222	ribosome binding
STH3087	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
STH3089	COG0081	regulation of translation
STH3090	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
STH3091	COG0250	Participates in transcription elongation, termination and antitermination
STH3093	COG0267	Belongs to the bacterial ribosomal protein bL33 family
STH3094	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
STH3097	COG4585	Histidine kinase
STH3098	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
STH31	COG3829	transcription factor binding
STH3100	COG0437	4 iron, 4 sulfur cluster binding
STH3103	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
STH3108	COG3706	GGDEF domain
STH3110	COG3344	reverse transcriptase
STH3111	COG0456	acetyltransferase
STH3114	COG2720	vancomycin resistance protein
STH3115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
STH3117	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
STH3118	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
STH3119	COG0215	cysteine-tRNA ligase activity
STH3120	COG1045	serine acetyltransferase
STH3121	COG3344	reverse transcriptase
STH3122	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
STH3123	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
STH3124	COG4956	integral membrane protein (PIN domain superfamily)
STH3125	COG1329	Transcriptional regulator
STH3127	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
STH3128	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
STH3129	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
STH3131	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
STH3133	COG0542	response to heat
STH3134	COG3869	Catalyzes the specific phosphorylation of arginine residues in
STH3135	COG3880	PFAM UvrB UvrC protein
STH3140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
STH3141	COG0546	phosphoglycolate phosphatase activity
STH3142	COG2878	Part of a membrane complex involved in electron transport
STH3153	COG3278	Belongs to the heme-copper respiratory oxidase family
STH3158	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
STH3160	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
STH3161	COG1307	EDD domain protein, DegV family
STH3162	COG2197	response regulator
STH3163	COG4585	Histidine kinase
STH3164	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
STH3166	COG0405	Gamma-glutamyltransferase
STH3167	COG1013	pyruvate-flavodoxin oxidoreductase activity
STH3167	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
STH3167	COG0674	pyruvate-flavodoxin oxidoreductase activity
STH3167	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
STH3170	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
STH3171	COG0724	RNA recognition motif
STH3172	COG0772	Belongs to the SEDS family
STH3174	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
STH3175	COG1053	succinate dehydrogenase
STH3176	COG2009	succinate dehydrogenase
STH3178	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
STH3180	COG0314	molybdopterin synthase activity
STH3183	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
STH3184	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
STH3185	COG0157	Belongs to the NadC ModD family
STH3186	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
STH3187	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
STH3188	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
STH3189	COG2759	Belongs to the formate--tetrahydrofolate ligase family
STH319	COG0823	Involved in the tonB-independent uptake of proteins
STH319	COG1506	peptidase
STH319	COG4946	Tricorn protease homolog
STH3191	COG1228	amidohydrolase
STH3193	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
STH3194	COG2986	histidine ammonia-lyase
STH3195	COG0612	Peptidase, M16
STH3196	COG0612	Peptidase, M16
STH3198	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STH3199	COG0037	tRNA processing
STH3201	COG0303	'Molybdopterin
STH3202	COG1763	Mo-molybdopterin cofactor biosynthetic process
STH321	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
STH3211	COG0577	efflux transmembrane transporter activity
STH3212	COG1136	(ABC) transporter
STH3213	COG5002	protein histidine kinase activity
STH3214	COG0745	RESPONSE REGULATOR receiver
STH3215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
STH3217	COG3842	ATPase activity
STH3219	COG1840	ABC-type Fe3 transport system, periplasmic component
STH322	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
STH3220	COG2197	response regulator
STH3229	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
STH3231	COG3956	TIGRFAM MazG family protein
STH3233	COG2244	polysaccharide biosynthetic process
STH3234	COG2002	toxin-antitoxin pair type II binding
STH3235	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
STH3237	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
STH3238	COG0193	aminoacyl-tRNA hydrolase activity
STH3239	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
STH3240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
STH3241	COG2088	sporulation resulting in formation of a cellular spore
STH3243	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
STH3244	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
STH3245	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
STH3246	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
STH3247	COG4466	Protein conserved in bacteria
STH3248	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
STH3249	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
STH3250	COG3584	3D domain protein
STH3250	COG1388	LysM domain
STH3251	COG0084	hydrolase, TatD family'
STH3252	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
STH3252	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
STH3253	COG2002	toxin-antitoxin pair type II binding
STH3254	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
STH3255	COG1774	PSP1 C-terminal conserved region
STH3257	COG3870	Protein conserved in bacteria
STH3258	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
STH3259	COG1982	Orn Lys Arg decarboxylase major
STH3260	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
STH3262	COG0674	pyruvate-flavodoxin oxidoreductase activity
STH3265	COG2959	enzyme of heme biosynthesis
STH3266	COG3773	Cell wall hydrolase
STH3266	COG3409	Peptidoglycan-binding domain 1 protein
STH3267	COG1388	LysM domain
STH3269	COG1982	Orn Lys Arg decarboxylase major
STH3270	COG2323	membrane
STH3273	COG1309	transcriptional regulator
STH3277	COG1132	(ABC) transporter
STH3278	COG1132	(ABC) transporter
STH3280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
STH3285	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
STH3289	COG2205	protein histidine kinase activity
STH3290	COG0745	RESPONSE REGULATOR receiver
STH3291	COG3142	Participates in the control of copper homeostasis
STH3292	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
STH3294	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
STH3295	COG3383	formate dehydrogenase (NAD+) activity
STH3296	COG3383	formate dehydrogenase (NAD+) activity
STH3299	COG2204	response regulator
STH33	COG2814	Major facilitator Superfamily
STH3300	COG4191	Histidine kinase
STH3301	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
STH3303	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
STH3304	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
STH3307	COG5002	protein histidine kinase activity
STH3308	COG0745	RESPONSE REGULATOR receiver
STH3312	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
STH3313	COG3344	reverse transcriptase
STH3314	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
STH3315	COG0305	Participates in initiation and elongation during chromosome replication
STH3316	COG1067	ATP-dependent peptidase activity
STH3316	COG0470	DNA polymerase III
STH3317	COG0359	binds to the 23S rRNA
STH3319	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
STH3321	COG0360	Binds together with S18 to 16S ribosomal RNA
STH3327	COG0739	heme binding
STH3332	COG1475	DNA binding
STH3333	COG1192	Involved in chromosome partitioning
STH3334	COG0357	Ribosomal RNA small subunit methyltransferase G
STH3335	COG0445	tRNA wobble uridine modification
STH3336	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
STH3337	COG1847	R3H domain protein
STH3338	COG0706	membrane insertase activity
STH3339	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
STH3340	COG0594	ribonuclease P activity
STH3341	COG0230	Belongs to the bacterial ribosomal protein bL34 family
STH339	COG0557	exoribonuclease II activity
STH34	COG0604	alcohol dehydrogenase
STH340	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
STH341	COG1846	Transcriptional regulator
STH342	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
STH343	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
STH344	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
STH345	COG0622	Phosphoesterase
STH346	COG2155	Conserved Protein
STH350	COG1263	PTS System
STH350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
STH350	COG2190	(PTS) system
STH351	COG3711	transcriptional antiterminator
STH352	COG1160	GTP binding
STH353	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
STH354	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
STH356	COG0446	pyridine nucleotide-disulphide oxidoreductase
STH357	COG0544	peptidyl-prolyl cis-trans isomerase activity
STH358	COG0740	serine-type endopeptidase activity
STH359	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
STH360	COG0470	DNA polymerase III
STH360	COG1067	ATP-dependent peptidase activity
STH361	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
STH362	COG0218	Necessary for normal cell division and for the maintenance of normal septation
STH366	COG0525	valine-tRNA ligase activity
STH37	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
STH370	COG0424	maF-like protein
STH371	COG2003	Belongs to the UPF0758 family
STH372	COG1077	Cell shape determining protein MreB Mrl
STH375	COG0850	regulation of cytokinetic process
STH376	COG2894	cell division
STH377	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
STH379	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
STH38	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STH382	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
STH387	COG2894	cell division
STH389	COG0489	protein tyrosine kinase activity
STH4	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
STH40	COG0504	CTP synthase activity
STH409	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
STH41	COG1078	dGTPase activity
STH410	COG0640	Transcriptional regulator
STH415	COG0745	RESPONSE REGULATOR receiver
STH416	COG0642	Histidine kinase
STH416	COG3850	Histidine kinase
STH421	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
STH422	COG0517	IMP dehydrogenase activity
STH422	COG1994	Peptidase M50
STH423	COG1032	radical SAM domain protein
STH426	COG1530	ribonuclease E activity
STH427	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
STH429	COG0261	This protein binds to 23S rRNA in the presence of protein L20
STH43	COG0497	DNA recombination
STH430	COG2868	ribosomal protein
STH431	COG0211	Belongs to the bacterial ribosomal protein bL27 family
STH432	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
STH434	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
STH435	COG1713	HD superfamily hydrolase involved in NAD metabolism
STH436	COG0799	negative regulation of ribosome biogenesis
STH437	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
STH438	COG3290	protein histidine kinase activity
STH438	COG3829	transcription factor binding
STH439	COG3033	Beta-eliminating lyase
STH441	COG3033	Beta-eliminating lyase
STH442	COG0733	neurotransmitter:sodium symporter activity
STH444	COG0495	leucyl-tRNA aminoacylation
STH45	COG1484	DNA-dependent DNA replication
STH451	COG0179	Fumarylacetoacetate (FAA) hydrolase
STH452	COG1132	(ABC) transporter
STH453	COG1132	(ABC) transporter
STH459	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
STH462	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
STH463	COG0714	Associated with various cellular activities
STH468	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
STH469	COG1177	transmembrane transport
STH470	COG1176	ABC-type spermidine putrescine transport system, permease component I
STH471	COG3842	ATPase activity
STH473	COG0658	competence protein
STH473	COG2333	competence protein COMEC
STH476	COG0268	Binds directly to 16S ribosomal RNA
STH478	COG1388	LysM domain
STH478	COG3858	chitin binding
STH480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
STH482	COG0481	GTPase activity
STH483	COG0635	Involved in the biosynthesis of porphyrin-containing compound
STH485	COG3025	triphosphatase activity
STH486	COG0165	Argininosuccinate lyase
STH488	COG0765	amino acid transport
STH489	COG0765	amino acid transport
STH490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
STH492	COG2197	response regulator
STH493	COG4585	Histidine kinase
STH493	COG2203	Gaf domain
STH494	COG0746	molybdenum cofactor guanylyltransferase activity
STH50	COG4584	PFAM Integrase catalytic
STH501	COG0519	Catalyzes the synthesis of GMP from XMP
STH501	COG0518	GMP synthase (glutamine-hydrolyzing) activity
STH502	COG1420	regulation of RNA biosynthetic process
STH504	COG0443	Heat shock 70 kDa protein
STH505	COG0484	heat shock protein binding
STH507	COG2264	protein methyltransferase activity
STH508	COG1385	rRNA (uridine-N3-)-methyltransferase activity
STH51	COG4584	PFAM Integrase catalytic
STH512	COG1181	Belongs to the D-alanine--D-alanine ligase family
STH513	COG0537	adenosine 5'-monophosphoramidase activity
STH514	COG0828	Belongs to the bacterial ribosomal protein bS21 family
STH515	COG1610	YqeY-like protein
STH518	COG0243	molybdopterin cofactor binding
STH519	COG1030	water channel activity
STH52	COG1484	DNA-dependent DNA replication
STH520	COG4864	UPF0365 protein
STH529	COG1702	phosphate starvation-inducible protein PhoH
STH53	COG1484	DNA-dependent DNA replication
STH530	COG1480	7TM receptor with intracellular HD hydrolase
STH531	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
STH532	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
STH534	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
STH535	COG1979	alcohol dehydrogenase
STH537	COG1388	LysM domain
STH537	COG3858	chitin binding
STH538	COG2267	carboxylic ester hydrolase activity
STH539	COG2239	Acts as a magnesium transporter
STH541	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
STH542	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
STH543	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH549	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STH55	COG3409	Peptidoglycan-binding domain 1 protein
STH55	COG3267	Type II secretory pathway component ExeA
STH550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
STH552	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
STH553	COG3457	Alanine racemase
STH554	COG1735	metal-dependent hydrolase with the TIM-barrel fold
STH557	COG2188	Transcriptional regulator
STH559	COG0626	cystathionine gamma-synthase activity
STH562	COG2222	sugar isomerase
STH564	COG2340	Cysteine-rich secretory protein family
STH565	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
STH566	COG3706	GGDEF domain
STH568	COG1381	Involved in DNA repair and RecF pathway recombination
STH569	COG0601	transmembrane transport
STH570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH571	COG0601	transmembrane transport
STH573	COG4124	Belongs to the glycosyl hydrolase 26 family
STH574	COG0752	glycyl-tRNA synthetase alpha subunit
STH575	COG0751	glycine-tRNA ligase activity
STH583	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
STH584	COG0508	dehydrogenase complex catalyzes the overall conversion of
STH585	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
STH586	COG0574	Belongs to the PEP-utilizing enzyme family
STH586	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
STH587	COG0358	DNA primase activity
STH588	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
STH589	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
STH590	COG2224	Isocitrate lyase
STH598	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
STH6	COG0187	DNA topoisomerase II activity
STH60	COG0793	Belongs to the peptidase S41A family
STH60	COG3409	Peptidoglycan-binding domain 1 protein
STH600	COG1408	metallophosphoesterase
STH601	COG1028	Short-chain dehydrogenase reductase Sdr
STH602	COG1940	carbohydrate kinase activity
STH604	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
STH606	COG0363	glucosamine-6-phosphate deaminase activity
STH607	COG0577	efflux transmembrane transporter activity
STH608	COG1136	(ABC) transporter
STH611	COG0210	DNA helicase
STH612	COG2096	Adenosyltransferase
STH616	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
STH619	COG0318	PFAM AMP-dependent synthetase and ligase
STH623	COG0247	lactate metabolic process
STH623	COG2181	nitrate reductase activity
STH624	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STH627	COG1393	Belongs to the ArsC family
STH629	COG0535	radical SAM domain protein
STH63	COG1607	acyl-coa hydrolase
STH632	COG1132	(ABC) transporter
STH633	COG1132	(ABC) transporter
STH635	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
STH636	COG3876	Protein conserved in bacteria
STH638	COG0778	Nitroreductase
STH64	COG3246	L-lysine catabolic process to acetate
STH641	COG1104	cysteine desulfurase activity
STH642	COG1271	oxidase subunit
STH643	COG1294	oxidase, subunit
STH646	COG1012	belongs to the aldehyde dehydrogenase family
STH647	COG0842	Transport permease protein
STH650	COG4585	Histidine kinase
STH653	COG1120	ATPase activity
STH657	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
STH658	COG0656	L-ascorbic acid biosynthetic process
STH66	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
STH667	COG1857	crispr-associated protein
STH67	COG1494	fructose-1,6-bisphosphatase
STH677	COG1136	(ABC) transporter
STH677	COG0577	efflux transmembrane transporter activity
STH68	COG0741	lytic transglycosylase activity
STH68	COG0739	heme binding
STH68	COG1196	nuclear chromosome segregation
STH680	COG0003	Pfam Anion-transporting ATPase
STH681	COG0003	Pfam Anion-transporting ATPase
STH683	COG1966	Carbon starvation protein
STH686	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
STH689	COG1131	(ABC) transporter
STH690	COG0745	RESPONSE REGULATOR receiver
STH692	COG0812	UDP-N-acetylmuramate dehydrogenase activity
STH693	COG0840	transmembrane signaling receptor activity
STH694	COG1136	(ABC) transporter
STH697	COG1073	alpha beta
STH7	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
STH700	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
STH702	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
STH704	COG0318	PFAM AMP-dependent synthetase and ligase
STH705	COG0559	Belongs to the binding-protein-dependent transport system permease family
STH709	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
STH71	COG0254	rRNA binding
STH712	COG0437	4 iron, 4 sulfur cluster binding
STH713	COG0243	molybdopterin cofactor binding
STH718	COG1404	Belongs to the peptidase S8 family
STH718	COG4412	M6 family metalloprotease domain protein
STH719	COG2718	Belongs to the UPF0229 family
STH72	COG3872	metal-dependent enzyme
STH720	COG0183	Belongs to the thiolase family
STH722	COG1012	belongs to the aldehyde dehydrogenase family
STH723	COG0840	transmembrane signaling receptor activity
STH724	COG2719	SpoVR family
STH727	COG5001	Diguanylate cyclase
STH727	COG3300	MHYT domain
STH729	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
STH73	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
STH731	COG0745	RESPONSE REGULATOR receiver
STH732	COG2205	protein histidine kinase activity
STH732	COG2202	Pas domain
STH734	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STH735	COG1333	cytochrome c biogenesis protein
STH736	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
STH737	COG1164	Oligoendopeptidase f
STH74	COG2890	protein-(glutamine-N5) methyltransferase activity
STH744	COG3344	reverse transcriptase
STH745	COG0704	Plays a role in the regulation of phosphate uptake
STH746	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
STH747	COG0581	inorganic phosphate transmembrane transporter activity
STH748	COG0573	inorganic phosphate transmembrane transporter activity
STH749	COG5002	protein histidine kinase activity
STH75	COG0009	L-threonylcarbamoyladenylate synthase
STH750	COG0745	RESPONSE REGULATOR receiver
STH751	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
STH755	COG1404	Belongs to the peptidase S8 family
STH757	COG0534	Mate efflux family protein
STH759	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
STH76	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
STH761	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
STH763	COG0573	inorganic phosphate transmembrane transporter activity
STH764	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
STH77	COG0698	ribose 5-phosphate isomerase
STH770	COG1609	Transcriptional regulator
STH771	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
STH772	COG1869	D-ribose catabolic process
STH773	COG1129	ABC transporter
STH775	COG0006	proline dipeptidase activity
STH779	COG0438	transferase activity, transferring glycosyl groups
STH78	COG4475	Protein of unknown function (DUF436)
STH780	COG0438	transferase activity, transferring glycosyl groups
STH781	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
STH783	COG5337	Spore coat protein CotH
STH786	COG0647	UMP catabolic process
STH788	COG2766	serine protein kinase
STH79	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
STH793	COG1349	DNA-binding transcription factor activity
STH795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
STH795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
STH795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
STH798	COG0318	PFAM AMP-dependent synthetase and ligase
STH8	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
STH80	COG2131	deaminase
STH800	COG0411	ABC transporter
STH802	COG0559	Belongs to the binding-protein-dependent transport system permease family
STH804	COG0183	Belongs to the thiolase family
STH808	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
STH81	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
STH814	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
STH815	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
STH816	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
STH817	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
STH818	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
STH819	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
STH82	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
STH822	COG0559	Belongs to the binding-protein-dependent transport system permease family
STH824	COG0411	ABC transporter
STH827	COG0561	phosphatase activity
STH830	COG1988	membrane-bound metal-dependent
STH833	COG1027	Aspartate ammonia-lyase
STH834	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
STH834	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
STH837	COG0205	6-phosphofructokinase activity
STH839	COG0824	Thioesterase
STH840	COG0489	protein tyrosine kinase activity
STH840	COG2151	metal-sulfur cluster biosynthetic enzyme
STH843	COG5002	protein histidine kinase activity
STH844	COG0745	RESPONSE REGULATOR receiver
STH847	COG3344	reverse transcriptase
STH849	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
STH85	COG0356	it plays a direct role in the translocation of protons across the membrane
STH851	COG0237	dephospho-CoA kinase activity
STH856	COG4181	ATPase activity
STH86	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
STH863	COG1331	Highly conserved protein containing a thioredoxin domain
STH864	COG3773	Cell wall hydrolase
STH867	COG0426	domain, Protein
STH867	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
STH87	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
STH872	COG0534	Mate efflux family protein
STH874	COG1116	anion transmembrane transporter activity
STH875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
STH877	COG1196	nuclear chromosome segregation
STH877	COG0741	lytic transglycosylase activity
STH877	COG0739	heme binding
STH88	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
STH880	COG3344	reverse transcriptase
STH881	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STH883	COG2843	Capsule synthesis protein
STH885	COG2226	methyltransferase
STH886	COG1201	RNA secondary structure unwinding
STH89	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
STH893	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
STH894	COG3344	reverse transcriptase
STH896	COG4656	Part of a membrane complex involved in electron transport
STH897	COG4658	electron transport chain
STH898	COG4659	FMN binding
STH899	COG4660	Part of a membrane complex involved in electron transport
STH9	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
STH90	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
STH900	COG4657	Part of a membrane complex involved in electron transport
STH901	COG1245	4Fe-4S binding domain
STH901	COG2878	Part of a membrane complex involved in electron transport
STH906	COG0823	Involved in the tonB-independent uptake of proteins
STH906	COG1506	peptidase
STH906	COG4946	Tricorn protease homolog
STH907	COG1595	DNA-templated transcription, initiation
STH91	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
STH910	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
STH913	COG0612	Peptidase, M16
STH914	COG0740	serine-type endopeptidase activity
STH916	COG0437	4 iron, 4 sulfur cluster binding
STH917	COG0243	molybdopterin cofactor binding
STH92	COG0355	proton-transporting ATP synthase activity, rotational mechanism
STH923	COG2197	response regulator
STH924	COG0589	response to stress
STH927	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STH930	COG0069	glutamate synthase activity
STH932	COG1942	4-Oxalocrotonate Tautomerase
STH934	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
STH94	COG1139	Iron-sulfur cluster binding protein
STH949	COG1489	DNA binding
STH952	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
STH954	COG2723	6-phospho-beta-galactosidase activity
STH955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
STH955	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
STH956	COG4946	Tricorn protease homolog
STH956	COG0823	Involved in the tonB-independent uptake of proteins
STH956	COG1506	peptidase
STH958	COG1253	flavin adenine dinucleotide binding
STH959	COG0501	Belongs to the peptidase M48B family
STH96	COG1620	l-lactate permease
STH960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
STH963	COG1252	NADH dehydrogenase
STH965	COG0492	ferredoxin-NADP+ reductase activity
STH968	COG1028	Short-chain dehydrogenase reductase Sdr
STH97	COG2186	Transcriptional regulator
STH971	COG2050	protein possibly involved in aromatic compounds catabolism
STH976	COG1136	(ABC) transporter
STH977	COG0577	efflux transmembrane transporter activity
STH982	COG0730	response to heat
STH983	COG0316	Belongs to the HesB IscA family
STH984	COG3344	reverse transcriptase
STH985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STH986	COG3275	phosphorelay sensor kinase activity
STH987	COG3279	Response regulator of the LytR AlgR family
STH989	COG1686	Belongs to the peptidase S11 family
STH990	COG0302	gtp cyclohydrolase
STH992	COG0247	lactate metabolic process
STH993	COG0277	FAD linked oxidase domain protein
STH997	COG4149	molybdate abc transporter
STH998	COG3842	ATPase activity