locus-tag	class	description
K6K13_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6K13_00010	COG0592	DNA-directed DNA polymerase activity
K6K13_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K6K13_00020	COG0187	DNA topoisomerase II activity
K6K13_00035	COG0561	phosphatase activity
K6K13_00045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K6K13_00055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6K13_00110	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K6K13_00130	COG5645	(Lipo)protein
K6K13_00135	COG0071	Belongs to the small heat shock protein (HSP20) family
K6K13_00140	COG0071	Belongs to the small heat shock protein (HSP20) family
K6K13_00155	COG3290	protein histidine kinase activity
K6K13_00160	COG4565	transcriptional regulatory protein
K6K13_00170	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K6K13_00190	COG3493	citrate carrier protein
K6K13_00200	COG0747	negative chemotaxis
K6K13_00205	COG0601	transmembrane transport
K6K13_00210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6K13_00215	COG0444	Belongs to the ABC transporter superfamily
K6K13_00220	COG4608	Belongs to the ABC transporter superfamily
K6K13_00225	COG1028	Short-chain dehydrogenase reductase Sdr
K6K13_00245	COG1966	Carbon starvation protein
K6K13_00250	COG2879	small protein
K6K13_00255	COG0523	cobalamin synthesis protein
K6K13_00270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6K13_00290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6K13_00295	COG4172	Belongs to the ABC transporter superfamily
K6K13_00300	COG4319	ketosteroid isomerase
K6K13_00310	COG0583	DNA-binding transcription factor activity
K6K13_00315	COG1846	Transcriptional regulator
K6K13_00325	COG0583	DNA-binding transcription factor activity
K6K13_00360	COG0457	Tetratricopeptide repeat
K6K13_00360	COG3118	belongs to the thioredoxin family
K6K13_00365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K6K13_00370	COG1215	transferase activity, transferring glycosyl groups
K6K13_00380	COG1192	Involved in chromosome partitioning
K6K13_00400	COG2194	sulfuric ester hydrolase activity
K6K13_00405	COG2199	diguanylate cyclase activity
K6K13_00405	COG2200	EAL domain
K6K13_00415	COG0612	Peptidase, M16
K6K13_00420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6K13_00425	COG1942	4-Oxalocrotonate Tautomerase
K6K13_00430	COG1295	ribonuclease BN
K6K13_00435	COG0477	Major facilitator Superfamily
K6K13_00450	COG1053	succinate dehydrogenase
K6K13_00450	COG3976	FMN-binding domain protein
K6K13_00460	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K6K13_00465	COG0425	Belongs to the sulfur carrier protein TusA family
K6K13_00470	COG2217	Heavy metal translocating P-type atpase
K6K13_00475	COG3714	YhhN family
K6K13_00490	COG3776	membrane
K6K13_00495	COG0742	ribosomal rna small subunit methyltransferase
K6K13_00500	COG0552	protein localization to endoplasmic reticulum
K6K13_00500	COG0552	protein localization to endoplasmic reticulum
K6K13_00505	COG2884	Cell division ATP-binding protein ftsE
K6K13_00510	COG2177	Part of the ABC transporter FtsEX involved in
K6K13_00530	COG0456	acetyltransferase
K6K13_00535	COG0683	leucine binding
K6K13_00560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6K13_00580	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K6K13_00585	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6K13_00590	COG0840	transmembrane signaling receptor activity
K6K13_00595	COG0840	transmembrane signaling receptor activity
K6K13_00600	COG0840	transmembrane signaling receptor activity
K6K13_00605	COG1653	transport
K6K13_00610	COG1175	transmembrane transport
K6K13_00615	COG0395	ABC-type sugar transport system, permease component
K6K13_00620	COG3842	ATPase activity
K6K13_00625	COG0584	glycerophosphoryl diester phosphodiesterase
K6K13_00640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K6K13_00655	COG2217	Heavy metal translocating P-type atpase
K6K13_00665	COG1937	Protein conserved in bacteria
K6K13_00670	COG2205	protein histidine kinase activity
K6K13_00675	COG0745	RESPONSE REGULATOR receiver
K6K13_00685	COG2814	Major facilitator Superfamily
K6K13_00690	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K6K13_00695	COG0205	6-phosphofructokinase activity
K6K13_00705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6K13_00710	COG2957	Belongs to the agmatine deiminase family
K6K13_00720	COG2066	Belongs to the glutaminase family
K6K13_00725	COG0149	triose-phosphate isomerase activity
K6K13_00735	COG1053	succinate dehydrogenase
K6K13_00740	COG1053	succinate dehydrogenase
K6K13_00755	COG1494	fructose-1,6-bisphosphatase
K6K13_00765	COG1609	Transcriptional regulator
K6K13_00770	COG1028	Short-chain dehydrogenase reductase Sdr
K6K13_00775	COG3265	gluconokinase activity
K6K13_00785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6K13_00790	COG3074	FtsZ-dependent cytokinesis
K6K13_00795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6K13_00805	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K6K13_00810	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K6K13_00815	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K6K13_00820	COG1609	Transcriptional regulator
K6K13_00825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6K13_00835	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
K6K13_00840	COG0626	cystathionine gamma-synthase activity
K6K13_00845	COG0460	homoserine dehydrogenase
K6K13_00845	COG0527	aspartate kinase activity
K6K13_00850	COG3842	ATPase activity
K6K13_00875	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K6K13_00895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6K13_00910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6K13_00915	COG4206	TonB-dependent receptor
K6K13_00920	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K6K13_00960	COG1126	abc transporter atp-binding protein
K6K13_00965	COG0765	amino acid transport
K6K13_00970	COG4597	amino acid ABC transporter
K6K13_00975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6K13_00980	COG0765	amino acid transport
K6K13_00985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6K13_00995	COG2910	NAD(P)H-binding
K6K13_01000	COG1116	anion transmembrane transporter activity
K6K13_01005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6K13_01010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6K13_01015	COG0154	amidase activity
K6K13_01025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6K13_01040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6K13_01045	COG0601	transmembrane transport
K6K13_01055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6K13_01070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6K13_01085	COG4948	Mandelate Racemase Muconate Lactonizing
K6K13_01090	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6K13_01105	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K6K13_01115	COG2264	protein methyltransferase activity
K6K13_01120	COG4145	pantothenate transmembrane transporter activity
K6K13_01125	COG3924	membrane
K6K13_01130	COG0439	Biotin carboxylase
K6K13_01135	COG0511	ligase activity, forming carbon-carbon bonds
K6K13_01140	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K6K13_01150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K6K13_01155	COG2199	diguanylate cyclase activity
K6K13_01155	COG2200	EAL domain
K6K13_01165	COG1077	Cell shape determining protein MreB Mrl
K6K13_01170	COG1792	Involved in formation and maintenance of cell shape
K6K13_01175	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K6K13_01180	COG0424	maF-like protein
K6K13_01185	COG1530	ribonuclease E activity
K6K13_01190	COG3164	Protein of unknown function
K6K13_01195	COG0312	modulator of DNA gyrase
K6K13_01215	COG1566	PFAM secretion protein HlyD family protein
K6K13_01225	COG3028	Belongs to the UPF0307 family
K6K13_01230	COG0312	modulator of DNA gyrase
K6K13_01240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6K13_01250	COG1660	Displays ATPase and GTPase activities
K6K13_01260	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6K13_01265	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K6K13_01270	COG1137	ATPase activity
K6K13_01275	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K6K13_01280	COG3117	lipopolysaccharide transmembrane transporter activity
K6K13_01285	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K6K13_01290	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K6K13_01290	COG0517	IMP dehydrogenase activity
K6K13_01295	COG0530	calcium, potassium:sodium antiporter activity
K6K13_01300	COG1127	ABC transporter
K6K13_01305	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K6K13_01310	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K6K13_01315	COG2854	intermembrane phospholipid transfer
K6K13_01320	COG3113	response to antibiotic
K6K13_01325	COG5007	Belongs to the BolA IbaG family
K6K13_01330	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6K13_01340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6K13_01345	COG3105	Protein conserved in bacteria
K6K13_01350	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K6K13_01360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K6K13_01365	COG0625	glutathione transferase activity
K6K13_01370	COG2969	positive regulation of protein catabolic process
K6K13_01380	COG0493	'glutamate synthase
K6K13_01385	COG0070	glutamate synthase
K6K13_01385	COG0067	glutamate synthase
K6K13_01385	COG0069	glutamate synthase activity
K6K13_01390	COG1242	4 iron, 4 sulfur cluster binding
K6K13_01395	COG2198	Histidine kinase
K6K13_01395	COG5002	protein histidine kinase activity
K6K13_01395	COG0784	Response regulator, receiver
K6K13_01400	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K6K13_01405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6K13_01415	COG2823	Periplasmic or secreted lipoprotein
K6K13_01420	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K6K13_01425	COG0792	nuclease activity
K6K13_01430	COG3107	peptidoglycan biosynthetic process
K6K13_01435	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K6K13_01455	COG3384	dioxygenase
K6K13_01465	COG0754	glutathionylspermidine amidase activity
K6K13_01470	COG5463	Belongs to the UPF0441 family
K6K13_01475	COG1538	Outer membrane efflux protein
K6K13_01480	COG0494	nUDIX hydrolase
K6K13_01485	COG3151	Protein conserved in bacteria
K6K13_01490	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K6K13_01495	COG3150	esterase
K6K13_01500	COG0187	DNA topoisomerase II activity
K6K13_01525	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6K13_01530	COG0583	DNA-binding transcription factor activity
K6K13_01535	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6K13_01545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6K13_01555	COG2132	Multicopper oxidase
K6K13_01565	COG3479	Phenolic acid decarboxylase
K6K13_01575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6K13_01585	COG2188	Transcriptional regulator
K6K13_01625	COG0848	biopolymer transport protein
K6K13_01635	COG0702	epimerase
K6K13_01640	COG0602	queuosine metabolic process
K6K13_01655	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K6K13_01660	COG0540	Belongs to the ATCase OTCase family
K6K13_01665	COG2731	YhcH YjgK YiaL family protein
K6K13_01670	COG1609	Transcriptional regulator
K6K13_01675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K6K13_01685	COG0456	acetyltransferase
K6K13_01690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K6K13_01695	COG0840	transmembrane signaling receptor activity
K6K13_01710	COG0525	valine-tRNA ligase activity
K6K13_01715	COG2927	DNA polymerase III (CHI subunit)
K6K13_01720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K6K13_01725	COG0795	lipopolysaccharide-transporting ATPase activity
K6K13_01730	COG0795	lipopolysaccharide-transporting ATPase activity
K6K13_01740	COG3842	ATPase activity
K6K13_01745	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
K6K13_01750	COG0725	ABC transporter, periplasmic molybdate-binding protein
K6K13_01755	COG2814	Major facilitator Superfamily
K6K13_01760	COG1454	alcohol dehydrogenase
K6K13_01780	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6K13_01790	COG3842	ATPase activity
K6K13_01795	COG1177	transmembrane transport
K6K13_01800	COG1349	DNA-binding transcription factor activity
K6K13_01810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6K13_01855	COG3585	molybdate ion transport
K6K13_01875	COG1283	sodium-dependent phosphate transmembrane transporter activity
K6K13_01880	COG3366	ferrous iron transmembrane transporter activity
K6K13_01885	COG0700	Nucleoside recognition
K6K13_01890	COG1473	amidohydrolase
K6K13_01895	COG0444	Belongs to the ABC transporter superfamily
K6K13_01905	COG0534	Mate efflux family protein
K6K13_01910	COG0840	transmembrane signaling receptor activity
K6K13_01915	COG2378	regulation of single-species biofilm formation
K6K13_01925	COG3254	rhamnose metabolic process
K6K13_01930	COG0235	Class ii aldolase
K6K13_01935	COG4806	L-rhamnose isomerase
K6K13_01940	COG1070	Carbohydrate kinase
K6K13_01945	COG2169	Transcriptional regulator
K6K13_01945	COG1917	Cupin 2, conserved barrel domain protein
K6K13_01950	COG1917	Cupin 2, conserved barrel domain protein
K6K13_01950	COG4977	sequence-specific DNA binding
K6K13_01955	COG3477	response to acidic pH
K6K13_01965	COG4948	Mandelate Racemase Muconate Lactonizing
K6K13_01970	COG2862	Uncharacterized protein family, UPF0114
K6K13_01975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6K13_01980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6K13_01985	COG0006	proline dipeptidase activity
K6K13_01990	COG3079	Belongs to the UPF0149 family
K6K13_01995	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K6K13_02005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K6K13_02020	COG0560	Phosphoserine phosphatase
K6K13_02025	COG3726	membrane protein affecting hemolysin expression
K6K13_02040	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K6K13_02045	COG2823	Periplasmic or secreted lipoprotein
K6K13_02050	COG5487	UPF0391 membrane protein
K6K13_02055	COG3237	CsbD-like
K6K13_02060	COG0084	hydrolase, TatD family'
K6K13_02065	COG0747	negative chemotaxis
K6K13_02075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6K13_02080	COG0444	Belongs to the ABC transporter superfamily
K6K13_02085	COG4608	Belongs to the ABC transporter superfamily
K6K13_02095	COG0583	DNA-binding transcription factor activity
K6K13_02110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6K13_02115	COG2977	Belongs to the P-Pant transferase superfamily
K6K13_02140	COG1309	transcriptional regulator
K6K13_02145	COG4232	protein-disulfide reductase activity
K6K13_02150	COG1324	tolerance protein
K6K13_02155	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6K13_02180	COG3161	chorismate lyase activity
K6K13_02185	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K6K13_02190	COG2937	Belongs to the GPAT DAPAT family
K6K13_02195	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6K13_02200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K6K13_02205	COG0735	belongs to the Fur family
K6K13_02210	COG1741	Belongs to the pirin family
K6K13_02215	COG0583	DNA-binding transcription factor activity
K6K13_02220	COG0435	Glutathione S-transferase
K6K13_02225	COG2259	Doxx family
K6K13_02235	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
K6K13_02240	COG4575	ribosome binding
K6K13_02255	COG0586	Pfam SNARE associated Golgi protein
K6K13_02265	COG2271	Major facilitator Superfamily
K6K13_02270	COG1904	glucuronate isomerase
K6K13_02275	COG0246	Mannitol dehydrogenase
K6K13_02290	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K6K13_02295	COG0861	Integral membrane protein TerC family
K6K13_02310	COG0673	inositol 2-dehydrogenase activity
K6K13_02315	COG2813	Specifically methylates the guanine in position
K6K13_02320	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6K13_02320	COG1902	pentaerythritol trinitrate reductase activity
K6K13_02330	COG1764	response to oxidative stress
K6K13_02335	COG1846	Transcriptional regulator
K6K13_02340	COG3678	ATP-independent chaperone mediated protein folding
K6K13_02360	COG0251	oxidation-reduction process
K6K13_02365	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K6K13_02375	COG1136	(ABC) transporter
K6K13_02390	COG0582	viral genome integration into host DNA
K6K13_02515	COG0305	Participates in initiation and elongation during chromosome replication
K6K13_02535	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
K6K13_02565	COG3772	lysozyme
K6K13_02580	COG1783	phage Terminase large subunit
K6K13_02585	COG3567	Phage-associated protein, HI1409 family
K6K13_02655	COG0741	lytic transglycosylase activity
K6K13_02655	COG0739	heme binding
K6K13_02655	COG1196	nuclear chromosome segregation
K6K13_02715	COG0582	viral genome integration into host DNA
K6K13_02730	COG3646	Phage regulatory protein
K6K13_02835	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K6K13_02845	COG0582	viral genome integration into host DNA
K6K13_02965	COG0305	Participates in initiation and elongation during chromosome replication
K6K13_03000	COG3617	BRO family, N-terminal domain
K6K13_03010	COG3772	lysozyme
K6K13_03070	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K6K13_03080	COG0582	viral genome integration into host DNA
K6K13_03125	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K6K13_03180	COG0358	DNA primase activity
K6K13_03185	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K6K13_03190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K6K13_03195	COG1438	arginine binding
K6K13_03205	COG3423	Transcriptional regulator
K6K13_03220	COG0142	geranyltranstransferase activity
K6K13_03225	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K6K13_03230	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K6K13_03235	COG0697	spore germination
K6K13_03240	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6K13_03245	COG2027	D-alanyl-D-alanine carboxypeptidase
K6K13_03255	COG1534	Rna-binding protein
K6K13_03260	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K6K13_03270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K6K13_03275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6K13_03280	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6K13_03345	COG0195	Participates in both transcription termination and antitermination
K6K13_03350	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K6K13_03355	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6K13_03360	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K6K13_03365	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K6K13_03370	COG1185	polyribonucleotide nucleotidyltransferase activity
K6K13_03380	COG0513	Belongs to the DEAD box helicase family
K6K13_03390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6K13_03395	COG0826	peptidase U32
K6K13_03400	COG0826	peptidase U32
K6K13_03405	COG3154	lipid carrier protein
K6K13_03410	COG3153	acetyltransferase
K6K13_03430	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K6K13_03435	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K6K13_03440	COG0813	purine-nucleoside phosphorylase activity
K6K13_03455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6K13_03460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K13_03475	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
K6K13_03480	COG1605	Chorismate mutase
K6K13_03485	COG2813	Specifically methylates the guanine in position
K6K13_03490	COG0667	Aldo Keto reductase
K6K13_03510	COG1454	alcohol dehydrogenase
K6K13_03515	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K6K13_03520	COG0509	glycine decarboxylation via glycine cleavage system
K6K13_03525	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6K13_03525	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6K13_03540	COG1272	protein, Hemolysin III
K6K13_03545	COG0354	folic acid binding
K6K13_03550	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K6K13_03565	COG0477	Major facilitator Superfamily
K6K13_03575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6K13_03580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6K13_03590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K6K13_03610	COG0243	molybdopterin cofactor binding
K6K13_03615	COG0437	4 iron, 4 sulfur cluster binding
K6K13_03620	COG3302	dmso reductase anchor subunit
K6K13_03625	COG3381	protein complex oligomerization
K6K13_03650	COG0726	polysaccharide deacetylase
K6K13_03655	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K6K13_03660	COG2076	Multidrug Resistance protein
K6K13_03675	COG2252	PERMEase
K6K13_03680	COG0025	NhaP-type Na H and K H
K6K13_03695	COG0129	dihydroxy-acid dehydratase activity
K6K13_03700	COG1609	Transcriptional regulator
K6K13_03705	COG3265	gluconokinase activity
K6K13_03715	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6K13_03720	COG3162	membrane
K6K13_03725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6K13_03735	COG4774	siderophore transport
K6K13_03740	COG1595	DNA-templated transcription, initiation
K6K13_03760	COG3655	Transcriptional regulator
K6K13_03765	COG0246	Mannitol dehydrogenase
K6K13_03775	COG1376	ErfK ybiS ycfS ynhG family protein
K6K13_03795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6K13_03955	COG4964	Belongs to the GSP D family
K6K13_03975	COG0348	domain, Protein
K6K13_03980	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K6K13_03985	COG2207	Transcriptional regulator
K6K13_03985	COG3708	Transcriptional regulator
K6K13_03995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6K13_04000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K13_04005	COG1120	ATPase activity
K6K13_04025	COG3711	transcriptional antiterminator
K6K13_04030	COG1263	PTS System
K6K13_04030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K13_04030	COG2190	(PTS) system
K6K13_04035	COG2723	6-phospho-beta-galactosidase activity
K6K13_04065	COG4774	siderophore transport
K6K13_04100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6K13_04100	COG4191	Histidine kinase
K6K13_04135	COG2867	negative regulation of translational initiation
K6K13_04140	COG2914	Belongs to the UPF0125 (RnfH) family
K6K13_04150	COG0497	DNA recombination
K6K13_04155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K6K13_04160	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K6K13_04165	COG1914	H( )-stimulated, divalent metal cation uptake system
K6K13_04170	COG1454	alcohol dehydrogenase
K6K13_04185	COG2271	Major facilitator Superfamily
K6K13_04195	COG1414	Transcriptional regulator
K6K13_04200	COG0494	nUDIX hydrolase
K6K13_04205	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6K13_04210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6K13_04215	COG0698	ribose 5-phosphate isomerase
K6K13_04225	COG2376	Dihydroxyacetone kinase
K6K13_04230	COG0149	triose-phosphate isomerase activity
K6K13_04235	COG1082	Xylose isomerase domain protein TIM barrel
K6K13_04240	COG2084	Dehydrogenase
K6K13_04245	COG2390	Transcriptional regulator
K6K13_04255	COG1671	Belongs to the UPF0178 family
K6K13_04260	COG0408	coproporphyrinogen oxidase activity
K6K13_04265	COG0456	acetyltransferase
K6K13_04270	COG1595	DNA-templated transcription, initiation
K6K13_04275	COG3712	iron ion homeostasis
K6K13_04280	COG4771	TonB-dependent receptor
K6K13_04285	COG0612	Peptidase, M16
K6K13_04305	COG2837	iron assimilation
K6K13_04315	COG1136	(ABC) transporter
K6K13_04315	COG0577	efflux transmembrane transporter activity
K6K13_04320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6K13_04325	COG0745	RESPONSE REGULATOR receiver
K6K13_04330	COG2205	protein histidine kinase activity
K6K13_04340	COG2190	(PTS) system
K6K13_04360	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K6K13_04365	COG3115	cell septum assembly
K6K13_04370	COG0531	amino acid
K6K13_04395	COG3436	PFAM IS66 Orf2 family protein
K6K13_04475	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6K13_04495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6K13_04615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K6K13_04665	COG0697	spore germination
K6K13_04670	COG0583	DNA-binding transcription factor activity
K6K13_04675	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K6K13_04680	COG0412	Dienelactone hydrolase
K6K13_04685	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K6K13_04695	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K6K13_04700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6K13_04705	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K6K13_04710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K6K13_04715	COG0165	Argininosuccinate lyase
K6K13_04720	COG1322	Protein conserved in bacteria
K6K13_04725	COG2226	methyltransferase
K6K13_04735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K6K13_04740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6K13_04745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6K13_04750	COG0805	protein transport
K6K13_04755	COG0084	hydrolase, TatD family'
K6K13_04770	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K6K13_04785	COG1609	Transcriptional regulator
K6K13_04795	COG1024	Enoyl-CoA hydratase
K6K13_04795	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6K13_04800	COG0006	proline dipeptidase activity
K6K13_04805	COG1739	Uncharacterized protein family UPF0029
K6K13_04810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6K13_04850	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K6K13_04855	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K6K13_04870	COG4589	Belongs to the CDS family
K6K13_04890	COG1410	methionine synthase
K6K13_04890	COG0646	methionine synthase
K6K13_04895	COG4115	mRNA cleavage
K6K13_04900	COG2161	toxin-antitoxin pair type II binding
K6K13_04925	COG0471	metal ion transport
K6K13_04935	COG0527	aspartate kinase activity
K6K13_04940	COG0166	Belongs to the GPI family
K6K13_04950	COG1509	lysine 2,3-aminomutase activity
K6K13_04960	COG0583	DNA-binding transcription factor activity
K6K13_04970	COG2814	Major facilitator Superfamily
K6K13_05000	COG2814	Major facilitator Superfamily
K6K13_05005	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K6K13_05010	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K6K13_05015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6K13_05020	COG1053	succinate dehydrogenase
K6K13_05025	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K6K13_05030	COG1511	domain protein
K6K13_05030	COG3264	Mechanosensitive ion channel
K6K13_05035	COG0688	phosphatidylethanolamine metabolic process
K6K13_05040	COG1162	GTPase activity
K6K13_05045	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K6K13_05065	COG0583	DNA-binding transcription factor activity
K6K13_05075	COG1881	PFAM PEBP family protein
K6K13_05090	COG0577	efflux transmembrane transporter activity
K6K13_05090	COG1136	(ABC) transporter
K6K13_05120	COG1609	Transcriptional regulator
K6K13_05125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K13_05125	COG1263	PTS System
K6K13_05130	COG2723	6-phospho-beta-galactosidase activity
K6K13_05135	COG2990	Protein conserved in bacteria
K6K13_05140	COG1230	cation diffusion facilitator family transporter
K6K13_05160	COG0582	viral genome integration into host DNA
K6K13_05175	COG3423	Transcriptional regulator
K6K13_05205	COG3423	Transcriptional regulator
K6K13_05225	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K6K13_05230	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K6K13_05235	COG2205	protein histidine kinase activity
K6K13_05240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6K13_05280	COG2011	ABC-type metal ion transport system permease component
K6K13_05285	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6K13_05290	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K6K13_05290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K6K13_05295	COG0802	atpase or kinase
K6K13_05305	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K6K13_05310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6K13_05315	COG1923	regulation of RNA biosynthetic process
K6K13_05320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6K13_05325	COG0330	HflC and HflK could
K6K13_05330	COG0330	HflC and HflK could
K6K13_05335	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K6K13_05340	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6K13_05345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6K13_05350	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K6K13_05355	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K6K13_05360	COG1678	Uncharacterized ACR, COG1678
K6K13_05365	COG0189	ligase activity
K6K13_05370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K6K13_05375	COG2356	endonuclease I
K6K13_05380	COG3091	SprT-like family
K6K13_05385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K6K13_05390	COG1166	arginine decarboxylase activity
K6K13_05400	COG0501	Belongs to the peptidase M48B family
K6K13_05405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6K13_05410	COG1414	Transcriptional regulator
K6K13_05415	COG0673	inositol 2-dehydrogenase activity
K6K13_05420	COG1653	transport
K6K13_05430	COG0395	ABC-type sugar transport system, permease component
K6K13_05435	COG3842	ATPase activity
K6K13_05440	COG0129	dihydroxy-acid dehydratase activity
K6K13_05450	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6K13_05455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6K13_05460	COG0126	phosphoglycerate kinase activity
K6K13_05470	COG0668	transmembrane transport
K6K13_05480	COG1279	arginine transmembrane transporter activity
K6K13_05485	COG2968	Membrane
K6K13_05490	COG0583	DNA-binding transcription factor activity
K6K13_05495	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K6K13_05500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6K13_05515	COG0840	transmembrane signaling receptor activity
K6K13_05520	COG0488	(ABC) transporter
K6K13_05525	COG0741	lytic transglycosylase activity
K6K13_05535	COG2223	nitrite transmembrane transporter activity
K6K13_05540	COG3056	Lipoprotein
K6K13_05550	COG0271	Belongs to the BolA IbaG family
K6K13_05555	COG0544	peptidyl-prolyl cis-trans isomerase activity
K6K13_05560	COG0740	serine-type endopeptidase activity
K6K13_05565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K6K13_05570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K6K13_05575	COG0776	regulation of translation
K6K13_05580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6K13_05585	COG1555	photosystem II stabilization
K6K13_05590	COG0824	Thioesterase
K6K13_05595	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K6K13_05605	COG1522	sequence-specific DNA binding
K6K13_05610	COG1132	(ABC) transporter
K6K13_05620	COG0347	Belongs to the P(II) protein family
K6K13_05625	COG0004	ammonium transporteR
K6K13_05630	COG1946	Acyl-CoA thioesterase
K6K13_05635	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K6K13_05640	COG3695	enzyme binding
K6K13_05660	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6K13_05670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6K13_05675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6K13_05680	COG1309	transcriptional regulator
K6K13_05685	COG1196	nuclear chromosome segregation
K6K13_05685	COG3264	Mechanosensitive ion channel
K6K13_05700	COG2832	Protein of unknown function (DUF454)
K6K13_05705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6K13_05710	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K6K13_05715	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K6K13_05720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K6K13_05725	COG0326	Molecular chaperone. Has ATPase activity
K6K13_05730	COG0563	adenylate kinase activity
K6K13_05735	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K6K13_05740	COG4651	solute:proton antiporter activity
K6K13_05740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6K13_05745	COG0737	Belongs to the 5'-nucleotidase family
K6K13_05750	COG5434	Belongs to the glycosyl hydrolase 28 family
K6K13_05760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6K13_05765	COG3735	TraB family
K6K13_05770	COG1585	Membrane protein implicated in regulation of membrane protease activity
K6K13_05775	COG0330	HflC and HflK could
K6K13_05780	COG0840	transmembrane signaling receptor activity
K6K13_05815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6K13_05825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6K13_05830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6K13_05840	COG0784	Response regulator, receiver
K6K13_05840	COG2205	protein histidine kinase activity
K6K13_05845	COG2197	response regulator
K6K13_05850	COG0642	Histidine kinase
K6K13_05850	COG2198	Histidine kinase
K6K13_05855	COG1169	isochorismate synthase
K6K13_05860	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K6K13_05865	COG0596	Alpha beta hydrolase
K6K13_05870	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K6K13_05875	COG1441	menaquinone biosynthetic process
K6K13_05890	COG0814	amino acid
K6K13_05900	COG3118	belongs to the thioredoxin family
K6K13_05905	COG0300	oxidoreductase activity
K6K13_05910	COG2755	lipolytic protein G-D-S-L family
K6K13_05915	COG4181	ATPase activity
K6K13_05930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6K13_05945	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K6K13_05950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K6K13_05960	COG2233	PERMEase
K6K13_05970	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6K13_05975	COG1393	Belongs to the ArsC family
K6K13_05980	COG4783	chaperone-mediated protein folding
K6K13_05985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6K13_05990	COG2716	regulation of RNA biosynthetic process
K6K13_06000	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K6K13_06005	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K6K13_06010	COG2707	UPF0756 membrane protein
K6K13_06015	COG1444	tRNA N-acetyltransferase activity
K6K13_06025	COG0494	nUDIX hydrolase
K6K13_06030	COG0400	carboxylic ester hydrolase activity
K6K13_06040	COG0183	Belongs to the thiolase family
K6K13_06045	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K6K13_06050	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K6K13_06070	COG0583	DNA-binding transcription factor activity
K6K13_06080	COG1876	peptidase activity
K6K13_06085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6K13_06090	COG1393	Belongs to the ArsC family
K6K13_06095	COG1794	racemase activity, acting on amino acids and derivatives
K6K13_06105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K6K13_06110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6K13_06115	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K6K13_06120	COG0321	lipoyl(octanoyl) transferase activity
K6K13_06125	COG2921	Belongs to the UPF0250 family
K6K13_06130	COG1686	Belongs to the peptidase S11 family
K6K13_06135	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K6K13_06140	COG0772	Belongs to the SEDS family
K6K13_06145	COG0768	penicillin binding
K6K13_06155	COG0799	negative regulation of ribosome biogenesis
K6K13_06160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6K13_06165	COG1466	dna polymerase III delta subunit
K6K13_06170	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K6K13_06175	COG0495	leucyl-tRNA aminoacylation
K6K13_06180	COG2888	peptidyl-tyrosine sulfation
K6K13_06185	COG1126	abc transporter atp-binding protein
K6K13_06190	COG0765	amino acid transport
K6K13_06195	COG0765	amino acid transport
K6K13_06205	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K6K13_06210	COG4535	Mg2 and Co2 transporter CorC
K6K13_06215	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K6K13_06220	COG1702	phosphate starvation-inducible protein PhoH
K6K13_06225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6K13_06230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6K13_06235	COG2076	Multidrug Resistance protein
K6K13_06275	COG0367	asparagine synthase
K6K13_06280	COG1846	Transcriptional regulator
K6K13_06280	COG1940	carbohydrate kinase activity
K6K13_06285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K6K13_06290	COG0363	glucosamine-6-phosphate deaminase activity
K6K13_06295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K13_06295	COG2190	(PTS) system
K6K13_06295	COG1263	PTS System
K6K13_06300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6K13_06305	COG0735	belongs to the Fur family
K6K13_06310	COG0716	FMN binding
K6K13_06315	COG0840	transmembrane signaling receptor activity
K6K13_06325	COG0596	Alpha beta hydrolase
K6K13_06330	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K6K13_06335	COG0033	Phosphoglucomutase
K6K13_06355	COG0745	RESPONSE REGULATOR receiver
K6K13_06365	COG3272	Protein of unknown function (DUF1722)
K6K13_06375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6K13_06380	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K6K13_06385	COG1984	allophanate hydrolase subunit 2
K6K13_06390	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K6K13_06395	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K6K13_06415	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K6K13_06420	COG1053	succinate dehydrogenase
K6K13_06425	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6K13_06430	COG0567	Dehydrogenase, E1 component
K6K13_06435	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6K13_06440	COG0045	succinate-CoA ligase (ADP-forming) activity
K6K13_06445	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K6K13_06450	COG1271	oxidase subunit
K6K13_06455	COG1294	oxidase, subunit
K6K13_06460	COG4890	Cyd operon protein YbgT
K6K13_06465	COG3790	cyd operon protein YbgE
K6K13_06480	COG0811	peptide transport
K6K13_06485	COG0848	biopolymer transport protein
K6K13_06490	COG3064	Membrane
K6K13_06490	COG3064	Membrane
K6K13_06495	COG0823	Involved in the tonB-independent uptake of proteins
K6K13_06500	COG2885	chlorophyll binding
K6K13_06505	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K6K13_06545	COG4221	oxidoreductase activity
K6K13_06550	COG0667	Aldo Keto reductase
K6K13_06560	COG1733	regulation of RNA biosynthetic process
K6K13_06570	COG1811	Na channel or pump
K6K13_06580	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6K13_06585	COG0588	phosphoglycerate mutase activity
K6K13_06590	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6K13_06595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6K13_06605	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6K13_06615	COG2017	converts alpha-aldose to the beta-anomer
K6K13_06635	COG1119	ATPase activity
K6K13_06640	COG3585	molybdate ion transport
K6K13_06640	COG2005	Transcriptional regulator
K6K13_06650	COG0725	ABC transporter, periplasmic molybdate-binding protein
K6K13_06655	COG4149	molybdate abc transporter
K6K13_06660	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K6K13_06665	COG0561	phosphatase activity
K6K13_06670	COG2706	6-phosphogluconolactonase activity
K6K13_06675	COG2864	formate dehydrogenase
K6K13_06680	COG0437	4 iron, 4 sulfur cluster binding
K6K13_06690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6K13_06690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6K13_06700	COG0572	uridine kinase
K6K13_06705	COG0717	Belongs to the dCTP deaminase family
K6K13_06710	COG2982	Protein involved in outer membrane biogenesis
K6K13_06715	COG3069	C4-dicarboxylate transmembrane transporter activity
K6K13_06725	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
K6K13_06730	COG1253	flavin adenine dinucleotide binding
K6K13_06735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6K13_06750	COG0489	protein tyrosine kinase activity
K6K13_06750	COG3206	protein involved in exopolysaccharide biosynthesis
K6K13_06775	COG0438	transferase activity, transferring glycosyl groups
K6K13_06820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K6K13_06825	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6K13_06870	COG3842	ATPase activity
K6K13_06875	COG1176	ABC-type spermidine putrescine transport system, permease component I
K6K13_06885	COG0006	proline dipeptidase activity
K6K13_06890	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K6K13_06895	COG1917	Cupin 2, conserved barrel domain protein
K6K13_06895	COG2207	Transcriptional regulator
K6K13_06900	COG0288	reversible hydration of carbon dioxide
K6K13_06905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6K13_06915	COG2271	Major facilitator Superfamily
K6K13_06920	COG1609	Transcriptional regulator
K6K13_06930	COG2188	Transcriptional regulator
K6K13_06945	COG3706	GGDEF domain
K6K13_06965	COG0784	Response regulator, receiver
K6K13_06965	COG0835	chemotaxis
K6K13_06985	COG1757	Na H antiporter
K6K13_07000	COG1064	alcohol dehydrogenase
K6K13_07005	COG0667	Aldo Keto reductase
K6K13_07015	COG1388	LysM domain
K6K13_07015	COG1470	cell adhesion involved in biofilm formation
K6K13_07020	COG1403	HNH endonuclease
K6K13_07030	COG1794	racemase activity, acting on amino acids and derivatives
K6K13_07035	COG0667	Aldo Keto reductase
K6K13_07040	COG0656	L-ascorbic acid biosynthetic process
K6K13_07065	COG5002	protein histidine kinase activity
K6K13_07075	COG0667	Aldo Keto reductase
K6K13_07080	COG1073	alpha beta
K6K13_07085	COG1028	Short-chain dehydrogenase reductase Sdr
K6K13_07090	COG1733	regulation of RNA biosynthetic process
K6K13_07105	COG1309	transcriptional regulator
K6K13_07115	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
K6K13_07125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6K13_07130	COG1704	LemA family
K6K13_07140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6K13_07145	COG0697	spore germination
K6K13_07150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6K13_07170	COG1522	sequence-specific DNA binding
K6K13_07195	COG0583	DNA-binding transcription factor activity
K6K13_07200	COG1301	dicarboxylic acid transport
K6K13_07210	COG3383	formate dehydrogenase (NAD+) activity
K6K13_07215	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6K13_07220	COG0840	transmembrane signaling receptor activity
K6K13_07225	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
K6K13_07235	COG3260	NADH ubiquinone oxidoreductase 20
K6K13_07240	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6K13_07245	COG3261	NADH dehydrogenase
K6K13_07245	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
K6K13_07250	COG0651	ATP synthesis coupled electron transport
K6K13_07255	COG4237	Hydrogenase 4 membrane
K6K13_07260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6K13_07265	COG0650	Formate hydrogenlyase subunit 4
K6K13_07270	COG0651	ATP synthesis coupled electron transport
K6K13_07275	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6K13_07290	COG0298	carbon dioxide binding
K6K13_07295	COG0672	)-iron permease
K6K13_07310	COG0577	efflux transmembrane transporter activity
K6K13_07310	COG1136	(ABC) transporter
K6K13_07320	COG0577	efflux transmembrane transporter activity
K6K13_07320	COG1136	(ABC) transporter
K6K13_07330	COG0697	spore germination
K6K13_07340	COG0583	DNA-binding transcription factor activity
K6K13_07345	COG1301	dicarboxylic acid transport
K6K13_07350	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6K13_07360	COG1012	belongs to the aldehyde dehydrogenase family
K6K13_07365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6K13_07370	COG0640	Transcriptional regulator
K6K13_07380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6K13_07385	COG2951	lytic endotransglycosylase activity
K6K13_07390	COG2723	6-phospho-beta-galactosidase activity
K6K13_07395	COG2723	6-phospho-beta-galactosidase activity
K6K13_07400	COG2197	response regulator
K6K13_07405	COG0697	spore germination
K6K13_07410	COG1846	Transcriptional regulator
K6K13_07415	COG1609	Transcriptional regulator
K6K13_07430	COG3842	ATPase activity
K6K13_07490	COG3829	transcription factor binding
K6K13_07530	COG1733	regulation of RNA biosynthetic process
K6K13_07600	COG3228	Belongs to the MtfA family
K6K13_07625	COG1470	cell adhesion involved in biofilm formation
K6K13_07625	COG1388	LysM domain
K6K13_07630	COG0401	homolog of Blt101
K6K13_07660	COG0303	'Molybdopterin
K6K13_07665	COG4172	Belongs to the ABC transporter superfamily
K6K13_07675	COG0601	transmembrane transport
K6K13_07680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6K13_07685	COG0281	malic enzyme
K6K13_07690	COG0295	cytidine deaminase activity
K6K13_07695	COG1346	cytolysis
K6K13_07700	COG1380	Effector of murein hydrolase LrgA
K6K13_07705	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6K13_07710	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K6K13_07715	COG0156	8-amino-7-oxononanoate synthase activity
K6K13_07720	COG2226	methyltransferase
K6K13_07725	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K6K13_07730	COG1357	PFAM Pentapeptide repeats (8 copies)
K6K13_07735	COG0556	nucleotide-excision repair
K6K13_07745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K6K13_07750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K6K13_07755	COG0521	Mo-molybdopterin cofactor biosynthetic process
K6K13_07765	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K6K13_07770	COG0314	molybdopterin synthase activity
K6K13_07775	COG0670	Belongs to the BI1 family
K6K13_07780	COG0842	Transport permease protein
K6K13_07785	COG0842	Transport permease protein
K6K13_07790	COG1131	(ABC) transporter
K6K13_07800	COG1309	transcriptional regulator
K6K13_07810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6K13_07815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K13_07820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K13_07825	COG1120	ATPase activity
K6K13_07835	COG0513	Belongs to the DEAD box helicase family
K6K13_07850	COG0833	amino acid
K6K13_07855	COG2040	homocysteine
K6K13_07890	COG1686	Belongs to the peptidase S11 family
K6K13_07900	COG1472	Belongs to the glycosyl hydrolase 3 family
K6K13_07920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K6K13_07940	COG1126	abc transporter atp-binding protein
K6K13_07945	COG0765	amino acid transport
K6K13_07950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6K13_07955	COG0783	Belongs to the Dps family
K6K13_07965	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6K13_07970	COG2807	transmembrane transport
K6K13_07975	COG0534	Mate efflux family protein
K6K13_07980	COG0640	Transcriptional regulator
K6K13_07985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6K13_08000	COG3706	GGDEF domain
K6K13_08005	COG5645	(Lipo)protein
K6K13_08040	COG3081	Nucleoid-associated protein
K6K13_08050	COG1061	Type III restriction enzyme res subunit
K6K13_08060	COG1187	pseudouridine synthase activity
K6K13_08065	COG2814	Major facilitator Superfamily
K6K13_08075	COG4172	Belongs to the ABC transporter superfamily
K6K13_08080	COG4239	(ABC) transporter, permease
K6K13_08085	COG4174	ABC transporter (Permease)
K6K13_08090	COG4166	transmembrane transport
K6K13_08095	COG0791	NLP P60 protein
K6K13_08100	COG0671	phosphoesterase, PA-phosphatase related
K6K13_08105	COG0523	cobalamin synthesis protein
K6K13_08110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K6K13_08135	COG1105	Belongs to the carbohydrate kinase PfkB family
K6K13_08140	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K6K13_08140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6K13_08140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6K13_08145	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K6K13_08155	COG0583	DNA-binding transcription factor activity
K6K13_08160	COG0833	amino acid
K6K13_08185	COG0583	DNA-binding transcription factor activity
K6K13_08190	COG0840	transmembrane signaling receptor activity
K6K13_08195	COG0582	viral genome integration into host DNA
K6K13_08280	COG1396	sequence-specific DNA binding
K6K13_08315	COG0305	Participates in initiation and elongation during chromosome replication
K6K13_08340	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
K6K13_08355	COG3772	lysozyme
K6K13_08440	COG4386	tail sheath protein
K6K13_08485	COG4381	Mu-like prophage protein gp46
K6K13_08500	COG5301	cellulose 1,4-beta-cellobiosidase activity
K6K13_08505	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K6K13_08510	COG0859	PFAM glycosyl transferase family 9
K6K13_08515	COG0302	gtp cyclohydrolase
K6K13_08520	COG2311	Membrane
K6K13_08525	COG2949	membrane
K6K13_08530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6K13_08535	COG2133	pyrroloquinoline quinone binding
K6K13_08540	COG0625	glutathione transferase activity
K6K13_08545	COG1464	Belongs to the NlpA lipoprotein family
K6K13_08550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K6K13_08555	COG2011	ABC-type metal ion transport system permease component
K6K13_08560	COG1686	Belongs to the peptidase S11 family
K6K13_08565	COG1349	DNA-binding transcription factor activity
K6K13_08570	COG0569	domain protein
K6K13_08570	COG2985	domain, Protein
K6K13_08600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K6K13_08605	COG3842	ATPase activity
K6K13_08615	COG1177	transmembrane transport
K6K13_08625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6K13_08630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6K13_08635	COG4160	amino acid transport
K6K13_08640	COG4215	(ABC) transporter
K6K13_08645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6K13_08650	COG1126	abc transporter atp-binding protein
K6K13_08655	COG0726	polysaccharide deacetylase
K6K13_08665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6K13_08670	COG1151	hydroxylamine reductase activity
K6K13_08680	COG3593	DNA synthesis involved in DNA repair
K6K13_08730	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K6K13_08755	COG1064	alcohol dehydrogenase
K6K13_08765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K13_08765	COG2190	(PTS) system
K6K13_08765	COG1263	PTS System
K6K13_08770	COG2723	6-phospho-beta-galactosidase activity
K6K13_08775	COG0583	DNA-binding transcription factor activity
K6K13_08785	COG2814	Major facilitator Superfamily
K6K13_08805	COG1451	nucleotide metabolic process
K6K13_08810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K6K13_08815	COG2200	EAL domain
K6K13_08840	COG0738	Major facilitator superfamily
K6K13_08875	COG1454	alcohol dehydrogenase
K6K13_08880	COG3300	MHYT domain
K6K13_08880	COG5001	Diguanylate cyclase
K6K13_08885	COG1757	Na H antiporter
K6K13_08890	COG1609	Transcriptional regulator
K6K13_08905	COG0583	DNA-binding transcription factor activity
K6K13_08915	COG3122	Protein conserved in bacteria
K6K13_08940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K6K13_08950	COG0534	Mate efflux family protein
K6K13_08955	COG0307	riboflavin synthase, alpha
K6K13_08960	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K6K13_08965	COG1609	Transcriptional regulator
K6K13_08975	COG0791	NLP P60 protein
K6K13_08980	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K6K13_08985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K6K13_08990	COG0346	lactoylglutathione lyase activity
K6K13_08995	COG3313	Fe-S protein
K6K13_09000	COG1846	Transcriptional regulator
K6K13_09010	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K6K13_09015	COG3895	Periplasmic Protein
K6K13_09020	COG0259	pyridoxamine-phosphate oxidase activity
K6K13_09025	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6K13_09030	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K6K13_09035	COG0625	glutathione transferase activity
K6K13_09045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6K13_09050	COG0671	phosphoesterase, PA-phosphatase related
K6K13_09055	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K6K13_09060	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K6K13_09065	COG0284	orotidine-5'-phosphate decarboxylase activity
K6K13_09070	COG0023	Translation Initiation Factor
K6K13_09080	COG0235	Class ii aldolase
K6K13_09085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6K13_09090	COG2364	Membrane
K6K13_09095	COG1966	Carbon starvation protein
K6K13_09100	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K6K13_09105	COG0243	molybdopterin cofactor binding
K6K13_09110	COG0583	DNA-binding transcription factor activity
K6K13_09125	COG4172	Belongs to the ABC transporter superfamily
K6K13_09130	COG4171	peptide transport system, permease
K6K13_09145	COG4166	transmembrane transport
K6K13_09150	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K6K13_09155	COG1842	Phage shock protein A
K6K13_09165	COG1983	PspC domain protein
K6K13_09170	COG3106	COG3106 Predicted ATPase
K6K13_09175	COG3768	UPF0283 membrane protein
K6K13_09185	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K6K13_09190	COG2866	Carboxypeptidase
K6K13_09205	COG0598	Magnesium transport protein CorA
K6K13_09225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6K13_09230	COG0840	transmembrane signaling receptor activity
K6K13_09235	COG2911	Protein conserved in bacteria
K6K13_09245	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K6K13_09260	COG3591	Belongs to the peptidase S1B family
K6K13_09275	COG2205	protein histidine kinase activity
K6K13_09280	COG0745	RESPONSE REGULATOR receiver
K6K13_09295	COG0387	Pfam Sodium calcium exchanger
K6K13_09305	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
K6K13_09315	COG2197	response regulator
K6K13_09325	COG2223	nitrite transmembrane transporter activity
K6K13_09330	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
K6K13_09335	COG1140	nitrate reductase beta subunit
K6K13_09340	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
K6K13_09345	COG2181	nitrate reductase activity
K6K13_09355	COG2261	transglycosylase associated protein
K6K13_09365	COG3842	ATPase activity
K6K13_09375	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6K13_09390	COG1176	ABC-type spermidine putrescine transport system, permease component I
K6K13_09400	COG1028	Short-chain dehydrogenase reductase Sdr
K6K13_09410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6K13_09435	COG0583	DNA-binding transcription factor activity
K6K13_09440	COG2072	flavoprotein involved in K transport
K6K13_09455	COG1177	transmembrane transport
K6K13_09480	COG2072	flavoprotein involved in K transport
K6K13_09485	COG1802	Transcriptional regulator
K6K13_09510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K6K13_09515	COG2011	ABC-type metal ion transport system permease component
K6K13_09520	COG4948	Mandelate Racemase Muconate Lactonizing
K6K13_09525	COG1464	Belongs to the NlpA lipoprotein family
K6K13_09535	COG0583	DNA-binding transcription factor activity
K6K13_09545	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
K6K13_09565	COG1473	amidohydrolase
K6K13_09575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6K13_09575	COG2226	methyltransferase
K6K13_09575	COG3433	isochorismatase activity
K6K13_09595	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6K13_09600	COG1021	2,3-dihydroxybenzoate-AMP ligase
K6K13_09605	COG1169	isochorismate synthase
K6K13_09615	COG4771	TonB-dependent receptor
K6K13_09625	COG0601	transmembrane transport
K6K13_09635	COG4172	Belongs to the ABC transporter superfamily
K6K13_09640	COG2375	cellular response to nickel ion
K6K13_09640	COG1132	(ABC) transporter
K6K13_09645	COG1132	(ABC) transporter
K6K13_09695	COG0642	Histidine kinase
K6K13_09700	COG0745	RESPONSE REGULATOR receiver
K6K13_09715	COG4977	sequence-specific DNA binding
K6K13_09735	COG0662	Cupin 2, conserved barrel domain protein
K6K13_09765	COG0583	DNA-binding transcription factor activity
K6K13_09775	COG0436	Aminotransferase
K6K13_09800	COG0012	GTP binding
K6K13_09805	COG0193	aminoacyl-tRNA hydrolase activity
K6K13_09815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K6K13_09820	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K6K13_09825	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K6K13_09830	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K6K13_09835	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K6K13_09840	COG2890	protein-(glutamine-N5) methyltransferase activity
K6K13_09850	COG2912	Transglutaminase-like superfamily
K6K13_09855	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K6K13_09865	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K6K13_09870	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K6K13_09875	COG1472	Belongs to the glycosyl hydrolase 3 family
K6K13_09885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6K13_09945	COG0477	Major facilitator Superfamily
K6K13_09950	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6K13_09955	COG1649	PFAM Uncharacterised BCR, COG1649
K6K13_09960	COG0628	permease
K6K13_09965	COG0483	inositol monophosphate 1-phosphatase activity
K6K13_09975	COG4677	pectinesterase activity
K6K13_09985	COG4628	conserved protein (DUF2132)
K6K13_09990	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6K13_09995	COG0076	glutamate decarboxylase activity
K6K13_10015	COG4221	oxidoreductase activity
K6K13_10045	COG0114	fumarate hydratase activity
K6K13_10050	COG1482	cell wall glycoprotein biosynthetic process
K6K13_10055	COG5339	Protein conserved in bacteria
K6K13_10065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K6K13_10075	COG0385	Bile acid
K6K13_10085	COG0673	inositol 2-dehydrogenase activity
K6K13_10100	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6K13_10105	COG1129	ABC transporter
K6K13_10110	COG1879	ABC-type sugar transport system periplasmic component
K6K13_10115	COG1069	ribulokinase activity
K6K13_10120	COG2160	L-arabinose isomerase activity
K6K13_10130	COG4657	Part of a membrane complex involved in electron transport
K6K13_10135	COG2878	Part of a membrane complex involved in electron transport
K6K13_10140	COG4656	Part of a membrane complex involved in electron transport
K6K13_10145	COG4658	electron transport chain
K6K13_10150	COG4659	FMN binding
K6K13_10160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6K13_10185	COG0616	signal peptide processing
K6K13_10190	COG1028	Short-chain dehydrogenase reductase Sdr
K6K13_10210	COG0009	L-threonylcarbamoyladenylate synthase
K6K13_10215	COG0613	PHP domain protein
K6K13_10225	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K6K13_10225	COG0512	Glutamine amidotransferase of anthranilate synthase
K6K13_10230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K6K13_10235	COG0134	indole-3-glycerol-phosphate synthase activity
K6K13_10235	COG0135	phosphoribosylanthranilate isomerase activity
K6K13_10240	COG0133	tryptophan synthase activity
K6K13_10245	COG0159	tryptophan synthase activity
K6K13_10255	COG3047	cAMP biosynthetic process
K6K13_10260	COG0727	PFAM Uncharacterised protein family (UPF0153)
K6K13_10275	COG1607	acyl-coa hydrolase
K6K13_10285	COG2350	Protein conserved in bacteria
K6K13_10300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6K13_10305	COG3099	Belongs to the UPF0263 family
K6K13_10320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6K13_10345	COG1435	thymidine kinase activity
K6K13_10360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K6K13_10365	COG0745	RESPONSE REGULATOR receiver
K6K13_10370	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6K13_10375	COG3012	SEC-C Motif Domain Protein
K6K13_10380	COG0788	formyltetrahydrofolate deformylase activity
K6K13_10395	COG2860	membrane
K6K13_10400	COG0708	Exodeoxyribonuclease III
K6K13_10410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6K13_10415	COG0778	Nitroreductase
K6K13_10425	COG0616	signal peptide processing
K6K13_10430	COG0252	asparaginase activity
K6K13_10435	COG1335	isochorismatase
K6K13_10440	COG3139	Protein of unknown function (DUF1315)
K6K13_10445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6K13_10450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6K13_10460	COG0656	L-ascorbic acid biosynthetic process
K6K13_10465	COG3713	MltA-interacting MipA family protein
K6K13_10470	COG2766	serine protein kinase
K6K13_10475	COG2718	Belongs to the UPF0229 family
K6K13_10485	COG0583	DNA-binding transcription factor activity
K6K13_10505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6K13_10515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6K13_10520	COG2719	SpoVR family
K6K13_10525	COG2186	Transcriptional regulator
K6K13_10530	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6K13_10535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K6K13_10540	COG4886	Leucine-rich repeat (LRR) protein
K6K13_10550	COG1422	Protein of unknown function (DUF1090)
K6K13_10570	COG2983	Belongs to the UPF0260 family
K6K13_10575	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6K13_10580	COG3100	YcgL domain-containing protein
K6K13_10585	COG0850	regulation of cytokinetic process
K6K13_10590	COG2894	cell division
K6K13_10595	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K6K13_10600	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K6K13_10605	COG0318	PFAM AMP-dependent synthetase and ligase
K6K13_10610	COG3065	identical protein binding
K6K13_10620	COG1199	ATP-dependent helicase activity
K6K13_10630	COG0251	oxidation-reduction process
K6K13_10640	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6K13_10645	COG0494	nUDIX hydrolase
K6K13_10650	COG1760	l-serine dehydratase
K6K13_10655	COG1253	flavin adenine dinucleotide binding
K6K13_10660	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K13_10660	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6K13_10665	COG3715	PTS system
K6K13_10670	COG3716	PTS system mannose fructose sorbose family IID component
K6K13_10675	COG4811	Protein of unknown function (DUF986)
K6K13_10680	COG1971	Probably functions as a manganese efflux pump
K6K13_10685	COG2226	methyltransferase
K6K13_10700	COG0803	Belongs to the bacterial solute-binding protein 9 family
K6K13_10705	COG1121	(ABC) transporter
K6K13_10710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6K13_10715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6K13_10720	COG3001	Fructosamine kinase
K6K13_10730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6K13_10735	COG1917	Cupin 2, conserved barrel domain protein
K6K13_10745	COG1175	transmembrane transport
K6K13_10750	COG0395	ABC-type sugar transport system, permease component
K6K13_10755	COG3842	ATPase activity
K6K13_10765	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K6K13_10770	COG2755	lipolytic protein G-D-S-L family
K6K13_10770	COG0657	acetylesterase activity
K6K13_10775	COG1988	membrane-bound metal-dependent
K6K13_10780	COG1823	symporter activity
K6K13_10790	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K6K13_10800	COG1132	(ABC) transporter
K6K13_10810	COG0776	regulation of translation
K6K13_10815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6K13_10815	COG0072	phenylalanine-tRNA ligase activity
K6K13_10820	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K6K13_10835	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K6K13_10840	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K6K13_10845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6K13_10850	COG4939	FMN-binding domain protein
K6K13_10855	COG1113	amino acid transport
K6K13_10875	COG0823	Involved in the tonB-independent uptake of proteins
K6K13_10880	COG0501	Belongs to the peptidase M48B family
K6K13_10885	COG2223	nitrite transmembrane transporter activity
K6K13_10890	COG3279	Response regulator of the LytR AlgR family
K6K13_10920	COG1028	Short-chain dehydrogenase reductase Sdr
K6K13_10925	COG1560	Kdo2-lipid A biosynthetic process
K6K13_11145	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
K6K13_11205	COG1484	DNA-dependent DNA replication
K6K13_11230	COG1396	sequence-specific DNA binding
K6K13_11300	COG0538	isocitrate dehydrogenase activity
K6K13_11305	COG1187	pseudouridine synthase activity
K6K13_11315	COG0482	sulfurtransferase activity
K6K13_11320	COG2915	High frequency lysogenization protein hflD homolog
K6K13_11325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K6K13_11330	COG0745	RESPONSE REGULATOR receiver
K6K13_11340	COG2850	peptidyl-arginine hydroxylation
K6K13_11350	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6K13_11355	COG3842	ATPase activity
K6K13_11365	COG1177	transmembrane transport
K6K13_11380	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K6K13_11400	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K6K13_11405	COG1956	GAF domain-containing protein
K6K13_11410	COG2995	paraquat-inducible protein a
K6K13_11415	COG3008	intermembrane lipid transfer
K6K13_11420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K6K13_11420	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
K6K13_11430	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K6K13_11460	COG4886	Leucine-rich repeat (LRR) protein
K6K13_11480	COG1528	Iron-storage protein
K6K13_11490	COG1770	oligopeptidase
K6K13_11495	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K6K13_11500	COG0800	Aldolase
K6K13_11505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K6K13_11510	COG1737	Transcriptional regulator
K6K13_11520	COG0840	transmembrane signaling receptor activity
K6K13_11525	COG1560	Kdo2-lipid A biosynthetic process
K6K13_11530	COG0739	heme binding
K6K13_11540	COG1121	(ABC) transporter
K6K13_11545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6K13_11550	COG2255	four-way junction helicase activity
K6K13_11555	COG0632	four-way junction helicase activity
K6K13_11570	COG0494	nUDIX hydrolase
K6K13_11575	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K6K13_11580	COG1801	Protein of unknown function DUF72
K6K13_11585	COG3788	relative of glutathione S-transferase, MAPEG superfamily
K6K13_11595	COG0500	methyltransferase
K6K13_11660	COG3142	Participates in the control of copper homeostasis
K6K13_11665	COG3102	Protein conserved in bacteria
K6K13_11670	COG0018	arginyl-trna synthetase
K6K13_11675	COG0728	peptidoglycan biosynthetic process
K6K13_11685	COG3132	Protein of unknown function, DUF480
K6K13_11690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6K13_11695	COG0477	Major facilitator Superfamily
K6K13_11705	COG3381	protein complex oligomerization
K6K13_11710	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K6K13_11730	COG3130	regulation of translation
K6K13_11740	COG0444	Belongs to the ABC transporter superfamily
K6K13_11745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6K13_11750	COG0601	transmembrane transport
K6K13_11755	COG0747	negative chemotaxis
K6K13_11760	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
K6K13_11770	COG3009	Protein conserved in bacteria
K6K13_11775	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K6K13_11775	COG3008	intermembrane lipid transfer
K6K13_11780	COG2995	paraquat-inducible protein a
K6K13_11785	COG0488	(ABC) transporter
K6K13_11790	COG0116	Belongs to the methyltransferase superfamily
K6K13_11790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6K13_11795	COG0633	Ferredoxin
K6K13_11795	COG3217	Mosc domain protein beta barrel domain protein
K6K13_11805	COG0167	dihydroorotate dehydrogenase activity
K6K13_11810	COG0308	aminopeptidase N
K6K13_11815	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K6K13_11820	COG0017	Asparaginyl-tRNA synthetase
K6K13_11830	COG1448	Aminotransferase
K6K13_11835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6K13_11840	COG3108	Peptidase M15
K6K13_11845	COG2989	Protein conserved in bacteria
K6K13_11850	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K6K13_11855	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K6K13_11860	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K6K13_11865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6K13_11870	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K6K13_11875	COG3173	Aminoglycoside phosphotransferase
K6K13_11880	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K6K13_11885	COG2835	tetraacyldisaccharide 4'-kinase activity
K6K13_11890	COG1663	tetraacyldisaccharide 4'-kinase activity
K6K13_11895	COG1132	(ABC) transporter
K6K13_11900	COG0658	competence protein
K6K13_11900	COG2333	competence protein COMEC
K6K13_11905	COG2926	Belongs to the UPF0265 family
K6K13_11910	COG4604	ABC transporter, ATP-binding protein
K6K13_11915	COG4605	iron ion homeostasis
K6K13_11925	COG4607	ABC-type enterochelin transport system periplasmic component
K6K13_12035	COG3772	lysozyme
K6K13_12065	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
K6K13_12085	COG0305	Participates in initiation and elongation during chromosome replication
K6K13_12215	COG2925	Exonuclease
K6K13_12220	COG0531	amino acid
K6K13_12225	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
K6K13_12230	COG3493	citrate carrier protein
K6K13_12235	COG0840	transmembrane signaling receptor activity
K6K13_12240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6K13_12245	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K6K13_12250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6K13_12255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K6K13_12260	COG0131	Imidazoleglycerol-phosphate dehydratase
K6K13_12260	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6K13_12265	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K6K13_12270	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K6K13_12280	COG0140	phosphoribosyl-ATP diphosphatase activity
K6K13_12280	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K6K13_12290	COG0776	regulation of translation
K6K13_12295	COG0539	negative regulation of cytoplasmic translation
K6K13_12300	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K6K13_12305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K6K13_12310	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K6K13_12315	COG1944	ATP diphosphatase activity
K6K13_12320	COG2116	formate transmembrane transporter activity
K6K13_12325	COG1882	Formate acetyltransferase
K6K13_12330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6K13_12355	COG0477	Major facilitator Superfamily
K6K13_12360	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K6K13_12365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6K13_12370	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K6K13_12375	COG1674	ftsk spoiiie
K6K13_12375	COG3107	peptidoglycan biosynthetic process
K6K13_12380	COG1522	sequence-specific DNA binding
K6K13_12385	COG0492	ferredoxin-NADP+ reductase activity
K6K13_12395	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K6K13_12400	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K6K13_12405	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K6K13_12410	COG0542	response to heat
K6K13_12415	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K6K13_12420	COG1278	Cold shock
K6K13_12465	COG3501	Rhs element vgr protein
K6K13_12475	COG2207	Transcriptional regulator
K6K13_12480	COG1979	alcohol dehydrogenase
K6K13_12485	COG1902	pentaerythritol trinitrate reductase activity
K6K13_12505	COG4238	major outer membrane lipoprotein
K6K13_12510	COG1376	ErfK ybiS ycfS ynhG family protein
K6K13_12510	COG1388	LysM domain
K6K13_12515	COG2166	iron-sulfur cluster assembly
K6K13_12520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6K13_12525	COG0719	Fe-S assembly protein
K6K13_12530	COG0396	ATPase activity
K6K13_12535	COG0719	Fe-S assembly protein
K6K13_12540	COG0316	Belongs to the HesB IscA family
K6K13_12550	COG2050	protein possibly involved in aromatic compounds catabolism
K6K13_12555	COG0247	lactate metabolic process
K6K13_12555	COG0277	FAD linked oxidase domain protein
K6K13_12560	COG0628	permease
K6K13_12570	COG1477	protein flavinylation
K6K13_12575	COG0574	Belongs to the PEP-utilizing enzyme family
K6K13_12575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K6K13_12580	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K6K13_12595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6K13_12600	COG3720	iron ion transport
K6K13_12605	COG4558	Periplasmic binding protein
K6K13_12610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K13_12615	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K6K13_12625	COG2200	EAL domain
K6K13_12630	COG0095	Lipoate-protein ligase
K6K13_12635	COG0791	NLP P60 protein
K6K13_12640	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K6K13_12645	COG0386	Belongs to the glutathione peroxidase family
K6K13_12650	COG4139	cobalamin transport
K6K13_12660	COG1940	carbohydrate kinase activity
K6K13_12665	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6K13_12670	COG1136	(ABC) transporter
K6K13_12675	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6K13_12680	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K6K13_12705	COG0443	Heat shock 70 kDa protein
K6K13_12715	COG1252	NADH dehydrogenase
K6K13_12720	COG3150	esterase
K6K13_12730	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
K6K13_12735	COG5633	Lipoprotein
K6K13_12740	COG0537	adenosine 5'-monophosphoramidase activity
K6K13_12745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K13_12745	COG1263	PTS System
K6K13_12750	COG0084	hydrolase, TatD family'
K6K13_12755	COG0470	DNA polymerase III
K6K13_12760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K6K13_12765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6K13_12770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6K13_12775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6K13_12780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6K13_12785	COG1028	Short-chain dehydrogenase reductase Sdr
K6K13_12795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6K13_12800	COG0416	fatty acid biosynthetic process
K6K13_12805	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K6K13_12820	COG0564	pseudouridine synthase activity
K6K13_12825	COG1530	ribonuclease E activity
K6K13_12825	COG1530	ribonuclease E activity
K6K13_12835	COG0418	dihydroorotase activity
K6K13_12855	COG1054	Belongs to the UPF0176 family
K6K13_12860	COG1902	pentaerythritol trinitrate reductase activity
K6K13_12870	COG1560	Kdo2-lipid A biosynthetic process
K6K13_12875	COG2943	transferase activity, transferring hexosyl groups
K6K13_12880	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K6K13_12895	COG0840	transmembrane signaling receptor activity
K6K13_12915	COG0589	response to stress
K6K13_12955	COG0670	Belongs to the BI1 family
K6K13_12960	COG2920	part of a sulfur-relay system
K6K13_12965	COG1254	Belongs to the acylphosphatase family
K6K13_12970	COG3785	DNA binding
K6K13_12975	COG1832	CoA-binding protein
K6K13_12985	COG1803	Methylglyoxal synthase
K6K13_12990	COG0210	DNA helicase
K6K13_12995	COG3304	Inner membrane component domain
K6K13_13000	COG1289	transmembrane transporter activity
K6K13_13005	COG3070	regulator of competence-specific genes
K6K13_13010	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
K6K13_13015	COG2885	chlorophyll binding
K6K13_13015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6K13_13020	COG3120	sequence-specific DNA binding
K6K13_13025	COG1067	ATP-dependent peptidase activity
K6K13_13030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6K13_13035	COG2979	Protein of unknown function (DUF533)
K6K13_13065	COG1702	phosphate starvation-inducible protein PhoH
K6K13_13080	COG0463	Glycosyl transferase, family 2
K6K13_13095	COG0438	transferase activity, transferring glycosyl groups
K6K13_13095	COG1216	Glycosyl transferase, family 2
K6K13_13105	COG1216	Glycosyl transferase, family 2
K6K13_13105	COG0438	transferase activity, transferring glycosyl groups
K6K13_13120	COG1677	Flagellar hook-basal body complex protein FliE
K6K13_13125	COG1766	The M ring may be actively involved in energy transduction
K6K13_13135	COG1317	bacterial-type flagellum organization
K6K13_13145	COG2882	bacterial-type flagellum organization
K6K13_13155	COG1580	Controls the rotational direction of flagella during chemotaxis
K6K13_13190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6K13_13205	COG1706	bacterial-type flagellum-dependent cell motility
K6K13_13210	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K6K13_13220	COG1749	Flagellar hook protein flgE
K6K13_13225	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K6K13_13230	COG1558	bacterial-type flagellum-dependent cell motility
K6K13_13235	COG1815	bacterial-type flagellum-dependent cell motility
K6K13_13245	COG2747	anti-sigma28 factor FlgM
K6K13_13270	COG0840	transmembrane signaling receptor activity
K6K13_13305	COG3188	usher protein
K6K13_13310	COG3121	Chaperone
K6K13_13320	COG0583	DNA-binding transcription factor activity
K6K13_13400	COG2003	Belongs to the UPF0758 family
K6K13_13430	COG4735	regulation of single-species biofilm formation
K6K13_13450	COG0582	viral genome integration into host DNA
K6K13_13480	COG0738	Major facilitator superfamily
K6K13_13490	COG2271	Major facilitator Superfamily
K6K13_13505	COG4670	ketone body catabolic process
K6K13_13510	COG1960	acyl-CoA dehydrogenase activity
K6K13_13515	COG1917	Cupin 2, conserved barrel domain protein
K6K13_13515	COG2207	Transcriptional regulator
K6K13_13520	COG2086	electron transfer activity
K6K13_13525	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K6K13_13530	COG0644	oxidoreductase
K6K13_13535	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
K6K13_13540	COG0318	PFAM AMP-dependent synthetase and ligase
K6K13_13545	COG4771	TonB-dependent receptor
K6K13_13550	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6K13_13560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K6K13_13565	COG0322	excinuclease ABC activity
K6K13_13570	COG2197	response regulator
K6K13_13590	COG1113	amino acid transport
K6K13_13645	COG0583	DNA-binding transcription factor activity
K6K13_13660	COG1028	Short-chain dehydrogenase reductase Sdr
K6K13_13665	COG0583	DNA-binding transcription factor activity
K6K13_13675	COG2814	Major facilitator Superfamily
K6K13_13680	COG1522	sequence-specific DNA binding
K6K13_13690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6K13_13695	COG3539	Fimbrial protein
K6K13_13710	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6K13_13720	COG0583	DNA-binding transcription factor activity
K6K13_13745	COG2149	membrane
K6K13_13775	COG2814	Major facilitator Superfamily
K6K13_13780	COG3058	Necessary for formate dehydrogenase activity
K6K13_13785	COG2864	formate dehydrogenase
K6K13_13790	COG0437	4 iron, 4 sulfur cluster binding
K6K13_13795	COG3383	formate dehydrogenase (NAD+) activity
K6K13_13795	COG0243	molybdopterin cofactor binding
K6K13_13805	COG0519	Catalyzes the synthesis of GMP from XMP
K6K13_13805	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K6K13_13820	COG3721	Heme iron utilization protein
K6K13_13830	COG4771	TonB-dependent receptor
K6K13_13850	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
K6K13_13855	COG0309	Hydrogenase expression formation protein (HypE)
K6K13_13865	COG0298	carbon dioxide binding
K6K13_13870	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
K6K13_13870	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
K6K13_13880	COG1773	rubredoxin
K6K13_13885	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
K6K13_13895	COG5557	Pfam Polysulphide reductase, NrfD
K6K13_13900	COG0437	4 iron, 4 sulfur cluster binding
K6K13_13910	COG0488	(ABC) transporter
K6K13_13920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6K13_13925	COG1263	PTS System
K6K13_13925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K13_13935	COG0366	Alpha amylase catalytic
K6K13_13945	COG4575	ribosome binding
K6K13_13950	COG1007	ATP synthesis coupled electron transport
K6K13_13955	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6K13_13960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6K13_13965	COG0713	ATP synthesis coupled electron transport
K6K13_13970	COG0839	Belongs to the complex I subunit 6 family
K6K13_13975	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6K13_13980	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K6K13_13990	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K6K13_13995	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K6K13_14000	COG0649	NAD binding
K6K13_14000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6K13_14005	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6K13_14010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6K13_14015	COG0583	DNA-binding transcription factor activity
K6K13_14020	COG0436	Aminotransferase
K6K13_14025	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K6K13_14030	COG0490	domain, Protein
K6K13_14030	COG0471	metal ion transport
K6K13_14035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6K13_14040	COG3013	Belongs to the UPF0304 family
K6K13_14050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6K13_14055	COG0280	phosphate acetyltransferase
K6K13_14055	COG0857	belongs to the CobB CobQ family
K6K13_14070	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K6K13_14075	COG0622	Phosphoesterase
K6K13_14080	COG4302	ethanolamine ammonia-lyase activity
K6K13_14085	COG4303	Ethanolamine ammonia lyase large subunit
K6K13_14090	COG0531	amino acid
K6K13_14095	COG1090	epimerase
K6K13_14110	COG4215	(ABC) transporter
K6K13_14115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6K13_14120	COG0163	prenyltransferase activity
K6K13_14125	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6K13_14130	COG1286	toxin biosynthetic process
K6K13_14135	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K6K13_14140	COG0285	dihydrofolate synthase activity
K6K13_14145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K6K13_14150	COG0586	Pfam SNARE associated Golgi protein
K6K13_14155	COG0101	tRNA pseudouridine synthase activity
K6K13_14160	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6K13_14165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6K13_14175	COG0697	spore germination
K6K13_14185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6K13_14190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6K13_14190	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K6K13_14195	COG3121	Chaperone
K6K13_14210	COG3121	Chaperone
K6K13_14225	COG3101	peptidyl-lysine hydroxylation
K6K13_14230	COG0730	response to heat
K6K13_14235	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
K6K13_14240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K6K13_14245	COG2890	protein-(glutamine-N5) methyltransferase activity
K6K13_14250	COG2840	Smr protein MutS2
K6K13_14255	COG2062	phosphohistidine phosphatase, SixA
K6K13_14315	COG1278	Cold shock
K6K13_14330	COG0477	Major facilitator Superfamily
K6K13_14345	COG1902	pentaerythritol trinitrate reductase activity
K6K13_14430	COG3866	Pectate lyase
K6K13_14435	COG3266	domain, Protein
K6K13_14445	COG0436	Aminotransferase
K6K13_14455	COG4948	Mandelate Racemase Muconate Lactonizing
K6K13_14460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6K13_14465	COG1511	domain protein
K6K13_14465	COG3264	Mechanosensitive ion channel
K6K13_14500	COG0322	excinuclease ABC activity
K6K13_14505	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
K6K13_14510	COG0644	oxidoreductase
K6K13_14515	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K6K13_14545	COG1924	4 iron, 4 sulfur cluster binding
K6K13_14555	COG0318	PFAM AMP-dependent synthetase and ligase
K6K13_14585	COG4771	TonB-dependent receptor
K6K13_14590	COG4178	(ABC) transporter
K6K13_14595	COG0612	Peptidase, M16
K6K13_14605	COG0513	Belongs to the DEAD box helicase family
K6K13_14615	COG1120	ATPase activity
K6K13_14620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K13_14625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6K13_14630	COG1045	serine acetyltransferase
K6K13_14640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K6K13_14650	COG0402	S-adenosylhomocysteine deaminase activity
K6K13_14660	COG0402	S-adenosylhomocysteine deaminase activity
K6K13_14670	COG3608	succinylglutamate desuccinylase aspartoacylase
K6K13_14670	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K6K13_14680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K6K13_14685	COG3829	transcription factor binding
K6K13_14690	COG2068	MobA-Related Protein
K6K13_14710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6K13_14715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6K13_14720	COG1116	anion transmembrane transporter activity
K6K13_14730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6K13_14735	COG0837	glucose binding
K6K13_14735	COG1737	Transcriptional regulator
K6K13_14765	COG3038	cytochrome b561
K6K13_14780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6K13_14790	COG0543	2 iron, 2 sulfur cluster binding
K6K13_14795	COG0167	dihydroorotate dehydrogenase activity
K6K13_14800	COG0583	DNA-binding transcription factor activity
K6K13_14805	COG2814	Major facilitator Superfamily
K6K13_14810	COG5001	Diguanylate cyclase
K6K13_14810	COG4251	negative regulation of phosphorylation
K6K13_14810	COG3706	GGDEF domain
K6K13_14810	COG2203	Gaf domain
K6K13_14815	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K6K13_14820	COG2501	S4 domain
K6K13_14825	COG0215	cysteine-tRNA ligase activity
K6K13_14835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6K13_14840	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6K13_14845	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K6K13_14850	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K6K13_14855	COG0814	amino acid
K6K13_14860	COG1760	l-serine dehydratase
K6K13_14870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6K13_14875	COG0581	inorganic phosphate transmembrane transporter activity
K6K13_14885	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6K13_14895	COG0840	transmembrane signaling receptor activity
K6K13_14900	COG4807	Protein conserved in bacteria
K6K13_14905	COG2239	Acts as a magnesium transporter
K6K13_14910	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K6K13_14915	COG1085	galactose-1-phosphate uridylyltransferase
K6K13_14920	COG1609	Transcriptional regulator
K6K13_14925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6K13_14930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6K13_14940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6K13_14945	COG0477	Major facilitator Superfamily
K6K13_14950	COG2205	protein histidine kinase activity
K6K13_14955	COG0745	RESPONSE REGULATOR receiver
K6K13_14975	COG0435	Glutathione S-transferase
K6K13_14980	COG0826	peptidase U32
K6K13_14990	COG1597	lipid kinase activity
K6K13_14995	COG3223	Belongs to the PsiE family
K6K13_15000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6K13_15010	COG2235	arginine
K6K13_15025	COG0351	phosphomethylpyrimidine kinase
K6K13_15030	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K6K13_15035	COG2916	Histone family protein nucleoid-structuring protein H-NS
K6K13_15050	COG1396	sequence-specific DNA binding
K6K13_15060	COG3423	Transcriptional regulator
K6K13_15075	COG5434	Belongs to the glycosyl hydrolase 28 family
K6K13_15080	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K6K13_15155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6K13_15165	COG3093	addiction module antidote protein HigA
K6K13_15185	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K6K13_15185	COG0519	Catalyzes the synthesis of GMP from XMP
K6K13_15190	COG0516	GMP reductase activity
K6K13_15190	COG0517	IMP dehydrogenase activity
K6K13_15195	COG1570	exodeoxyribonuclease VII activity
K6K13_15200	COG1645	bacterial-type flagellum-dependent swarming motility
K6K13_15210	COG1160	GTP binding
K6K13_15215	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6K13_15220	COG2976	Protein conserved in bacteria
K6K13_15225	COG0124	histidyl-tRNA synthetase
K6K13_15230	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K6K13_15235	COG1426	Protein conserved in bacteria
K6K13_15245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K6K13_15250	COG0105	UTP biosynthetic process
K6K13_15255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K13_15255	COG2190	(PTS) system
K6K13_15255	COG1263	PTS System
K6K13_15265	COG2897	thiosulfate sulfurtransferase activity
K6K13_15280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K6K13_15285	COG2975	iron-sulfur cluster assembly
K6K13_15290	COG0633	Ferredoxin
K6K13_15295	COG0443	Heat shock 70 kDa protein
K6K13_15300	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K6K13_15305	COG0316	Belongs to the HesB IscA family
K6K13_15310	COG0822	iron-sulfur transferase activity
K6K13_15320	COG1959	2 iron, 2 sulfur cluster binding
K6K13_15330	COG0483	inositol monophosphate 1-phosphatase activity
K6K13_15340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K13_15345	COG1120	ATPase activity
K6K13_15355	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
K6K13_15360	COG3683	transport system, periplasmic component
K6K13_15365	COG2814	Major facilitator Superfamily
K6K13_15390	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6K13_15395	COG1017	nitric oxide dioxygenase activity
K6K13_15395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6K13_15400	COG2755	lipolytic protein G-D-S-L family
K6K13_15405	COG4677	pectinesterase activity
K6K13_15410	COG0347	Belongs to the P(II) protein family
K6K13_15415	COG2204	response regulator
K6K13_15420	COG3170	Tfp pilus assembly protein FimV
K6K13_15425	COG2205	protein histidine kinase activity
K6K13_15430	COG0047	phosphoribosylformylglycinamidine synthase activity
K6K13_15430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K6K13_15435	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K6K13_15445	COG0560	Phosphoserine phosphatase
K6K13_15450	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K6K13_15460	COG3300	MHYT domain
K6K13_15460	COG5001	Diguanylate cyclase
K6K13_15480	COG2274	protein secretion by the type I secretion system
K6K13_15485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6K13_15495	COG2200	EAL domain
K6K13_15500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6K13_15510	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K6K13_15515	COG1381	Involved in DNA repair and RecF pathway recombination
K6K13_15520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6K13_15525	COG0571	ribonuclease III activity
K6K13_15535	COG0481	GTPase activity
K6K13_15540	COG3086	response to oxidative stress
K6K13_15545	COG3026	antisigma factor binding
K6K13_15550	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
K6K13_15560	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K6K13_15565	COG0513	Belongs to the DEAD box helicase family
K6K13_15570	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K6K13_15575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K6K13_15590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6K13_15610	COG2259	Doxx family
K6K13_15615	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K6K13_15620	COG4208	sulfate ABC transporter
K6K13_15630	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
K6K13_15635	COG3835	regulator
K6K13_15640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6K13_15645	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K6K13_15650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6K13_15655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6K13_15665	COG2026	Addiction module toxin, RelE StbE family
K6K13_15675	COG0316	Belongs to the HesB IscA family
K6K13_15685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K6K13_15695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K13_15700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6K13_15705	COG1120	ATPase activity
K6K13_15710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6K13_15715	COG1643	Atp-dependent helicase
K6K13_15720	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
K6K13_15725	COG1489	DNA binding
K6K13_15735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6K13_15740	COG0617	tRNA 3'-terminal CCA addition
K6K13_15745	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6K13_15750	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K6K13_15755	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K6K13_15760	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K6K13_15765	COG0842	Transport permease protein
K6K13_15770	COG1131	(ABC) transporter
K6K13_15775	COG0288	reversible hydration of carbon dioxide
K6K13_15780	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K6K13_15810	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K6K13_15815	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K6K13_15825	COG1780	Probably involved in ribonucleotide reductase function
K6K13_15890	COG4964	Belongs to the GSP D family
K6K13_15910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K6K13_15915	COG0328	RNA-DNA hybrid ribonuclease activity
K6K13_15920	COG2226	methyltransferase
K6K13_15925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6K13_15930	COG1388	LysM domain
K6K13_15930	COG0741	lytic transglycosylase activity
K6K13_15965	COG0542	response to heat
K6K13_15970	COG1496	oxidoreductase activity
K6K13_15980	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6K13_15985	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6K13_15995	COG0077	Prephenate dehydratase
K6K13_15995	COG1605	Chorismate mutase
K6K13_16000	COG0287	Prephenate dehydrogenase
K6K13_16000	COG1605	Chorismate mutase
K6K13_16005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6K13_16010	COG3279	Response regulator of the LytR AlgR family
K6K13_16025	COG0335	large ribosomal subunit rRNA binding
K6K13_16030	COG0336	Belongs to the RNA methyltransferase TrmD family
K6K13_16035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K6K13_16040	COG0228	four-way junction DNA binding
K6K13_16045	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6K13_16050	COG4137	Cytochrome C assembly protein
K6K13_16055	COG1854	S-ribosylhomocysteine lyase activity
K6K13_16060	COG2918	glutathione biosynthetic process
K6K13_16065	COG1238	metal cluster binding
K6K13_16070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6K13_16090	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K6K13_16095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6K13_16100	COG2137	regulation of response to DNA damage stimulus
K6K13_16105	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K6K13_16120	COG0456	acetyltransferase
K6K13_16135	COG2999	glutathione oxidoreductase activity
K6K13_16150	COG0840	transmembrane signaling receptor activity
K6K13_16155	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K6K13_16305	COG2207	Transcriptional regulator
K6K13_16315	COG5001	Diguanylate cyclase
K6K13_16315	COG4251	negative regulation of phosphorylation
K6K13_16315	COG3706	GGDEF domain
K6K13_16315	COG2203	Gaf domain
K6K13_16370	COG0505	Belongs to the CarA family
K6K13_16375	COG2850	peptidyl-arginine hydroxylation
K6K13_16380	COG1840	ABC-type Fe3 transport system, periplasmic component
K6K13_16385	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
K6K13_16420	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6K13_16425	COG0583	DNA-binding transcription factor activity
K6K13_16435	COG2226	methyltransferase
K6K13_16445	COG1696	Membrane protein involved in D-alanine export
K6K13_16450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6K13_16500	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K6K13_16505	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K6K13_16515	COG1073	alpha beta
K6K13_16520	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K6K13_16525	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6K13_16530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K6K13_16540	COG2226	methyltransferase
K6K13_16545	COG3034	peptidoglycan biosynthetic process
K6K13_16550	COG0121	glutamine amidotransferase
K6K13_16555	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K6K13_16560	COG1960	acyl-CoA dehydrogenase activity
K6K13_16565	COG3852	Histidine kinase
K6K13_16570	COG2204	response regulator
K6K13_16575	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K6K13_16580	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K6K13_16585	COG2031	fatty acid transporter
K6K13_16590	COG0183	Belongs to the thiolase family
K6K13_16595	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
K6K13_16600	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K6K13_16605	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K6K13_16610	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
K6K13_16615	COG0235	Class ii aldolase
K6K13_16620	COG0436	Aminotransferase
K6K13_16635	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K6K13_16645	COG0765	amino acid transport
K6K13_16655	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K6K13_16675	COG4175	Glycine betaine
K6K13_16680	COG4176	ABC-type proline glycine betaine transport system permease component
K6K13_16685	COG2113	Glycine betaine
K6K13_16690	COG2814	Major facilitator Superfamily
K6K13_16695	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
K6K13_16705	COG1846	Transcriptional regulator
K6K13_16715	COG1566	PFAM secretion protein HlyD family protein
K6K13_16720	COG2814	Major facilitator Superfamily
K6K13_16725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6K13_16730	COG3118	belongs to the thioredoxin family
K6K13_16735	COG3148	PFAM DTW domain containing protein
K6K13_16745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6K13_16750	COG1414	Transcriptional regulator
K6K13_16790	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6K13_16800	COG2011	ABC-type metal ion transport system permease component
K6K13_16805	COG1464	Belongs to the NlpA lipoprotein family
K6K13_16815	COG1720	tRNA m6t6A37 methyltransferase activity
K6K13_16820	COG0442	prolyl-tRNA aminoacylation
K6K13_16825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6K13_16835	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K6K13_16840	COG0585	pseudouridine synthase activity
K6K13_16845	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K6K13_16855	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K6K13_16865	COG0529	Catalyzes the synthesis of activated sulfate
K6K13_16870	COG2895	sulfate adenylyltransferase (ATP) activity
K6K13_16875	COG0175	sulfate reduction
K6K13_16880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K6K13_16880	COG1648	precorrin-2 dehydrogenase activity
K6K13_16975	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6K13_16980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6K13_16985	COG0720	synthase
K6K13_16990	COG0602	queuosine metabolic process
K6K13_17010	COG0504	CTP synthase activity
K6K13_17015	COG3956	TIGRFAM MazG family protein
K6K13_17020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6K13_17035	COG3545	Serine hydrolase
K6K13_17040	COG1929	Belongs to the glycerate kinase type-1 family
K6K13_17060	COG4948	Mandelate Racemase Muconate Lactonizing
K6K13_17070	COG2271	Major facilitator Superfamily
K6K13_17075	COG2721	sulfolactate sulfo-lyase activity
K6K13_17080	COG0840	transmembrane signaling receptor activity
K6K13_17090	COG3530	Putative quorum-sensing-regulated virulence factor
K6K13_17095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K6K13_17100	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K6K13_17100	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K6K13_17105	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K6K13_17115	COG4991	sh3 domain protein
K6K13_17120	COG0617	tRNA 3'-terminal CCA addition
K6K13_17125	COG2226	methyltransferase
K6K13_17130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6K13_17135	COG1968	undecaprenyl-diphosphatase activity
K6K13_17140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K6K13_17145	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K6K13_17150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K6K13_17160	COG2105	PFAM AIG2 family protein
K6K13_17165	COG2911	Protein conserved in bacteria
K6K13_17170	COG0729	surface antigen
K6K13_17175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6K13_17180	COG1253	flavin adenine dinucleotide binding
K6K13_17190	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K6K13_17200	COG0737	Belongs to the 5'-nucleotidase family
K6K13_17210	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
K6K13_17215	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K6K13_17225	COG0545	Peptidyl-prolyl cis-trans isomerase
K6K13_17230	COG3061	Opacity-associated protein A
K6K13_17235	COG3189	MarR family transcriptional regulator
K6K13_17240	COG0359	binds to the 23S rRNA
K6K13_17245	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K6K13_17250	COG2965	DNA replication, synthesis of RNA primer
K6K13_17265	COG1073	alpha beta
K6K13_17270	COG0840	transmembrane signaling receptor activity
K6K13_17285	COG3111	PFAM Bacterial OB fold (BOF) protein
K6K13_17295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6K13_17300	COG0557	exoribonuclease II activity
K6K13_17305	COG1959	2 iron, 2 sulfur cluster binding
K6K13_17315	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K6K13_17325	COG0402	S-adenosylhomocysteine deaminase activity
K6K13_17330	COG1802	Transcriptional regulator
K6K13_17335	COG1063	alcohol dehydrogenase
K6K13_17345	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6K13_17350	COG2805	Type II/IV secretion system protein
K6K13_17355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K6K13_17360	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6K13_17365	COG0762	integral membrane protein
K6K13_17370	COG1872	DUF167
K6K13_17375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K6K13_17380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6K13_17400	COG4948	Mandelate Racemase Muconate Lactonizing
K6K13_17405	COG0800	Aldolase
K6K13_17410	COG3734	2-keto-3-deoxy-galactonokinase
K6K13_17415	COG2186	Transcriptional regulator
K6K13_17425	COG0477	Major facilitator Superfamily
K6K13_17430	COG0204	Acyl-transferase
K6K13_17430	COG0318	PFAM AMP-dependent synthetase and ligase
K6K13_17435	COG0840	transmembrane signaling receptor activity
K6K13_17445	COG2186	Transcriptional regulator
K6K13_17455	COG2723	6-phospho-beta-galactosidase activity
K6K13_17460	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6K13_17465	COG1447	Phosphotransferase system cellobiose-specific component IIA
K6K13_17470	COG3835	regulator
K6K13_17485	COG2610	gluconate transmembrane transporter activity
K6K13_17495	COG3842	ATPase activity
K6K13_17515	COG0583	DNA-binding transcription factor activity
K6K13_17545	COG4221	oxidoreductase activity
K6K13_17550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6K13_17570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6K13_17575	COG1113	amino acid transport
K6K13_17590	COG1448	Aminotransferase
K6K13_17595	COG3706	GGDEF domain
K6K13_17600	COG0840	transmembrane signaling receptor activity
K6K13_17610	COG0629	single-stranded DNA binding
K6K13_17625	COG2146	nitrite reductase [NAD(P)H] activity
K6K13_17640	COG1609	Transcriptional regulator
K6K13_17645	COG1121	(ABC) transporter
K6K13_17650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6K13_17655	COG0803	Belongs to the bacterial solute-binding protein 9 family
K6K13_17660	COG3048	D-serine ammonia-lyase activity
K6K13_17665	COG2200	EAL domain
K6K13_17670	COG1349	DNA-binding transcription factor activity
K6K13_17675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K6K13_17680	COG3395	kinase activity
K6K13_17685	COG1454	alcohol dehydrogenase
K6K13_17705	COG2731	YhcH YjgK YiaL family protein
K6K13_17730	COG3112	Uncharacterised protein family (UPF0231)
K6K13_17740	COG0840	transmembrane signaling receptor activity
K6K13_17745	COG2188	Transcriptional regulator
K6K13_17750	COG2222	sugar isomerase
K6K13_17755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6K13_17760	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6K13_17765	COG4771	TonB-dependent receptor
K6K13_17770	COG2207	Transcriptional regulator
K6K13_17775	COG2079	MmgE PrpD family protein
K6K13_17785	COG0673	inositol 2-dehydrogenase activity
K6K13_17790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6K13_17795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6K13_17800	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6K13_17805	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K6K13_17810	COG2186	Transcriptional regulator
K6K13_17820	COG1113	amino acid transport
K6K13_17830	COG3725	Membrane protein required for beta-lactamase induction
K6K13_17835	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6K13_17840	COG4969	Belongs to the N-Me-Phe pilin family
K6K13_17845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6K13_17850	COG1459	type II secretion system
K6K13_17855	COG0516	GMP reductase activity
K6K13_17860	COG0237	dephospho-CoA kinase activity
K6K13_17865	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K6K13_17870	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K6K13_17875	COG0494	nUDIX hydrolase
K6K13_17880	COG0653	protein targeting
K6K13_17895	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K6K13_17900	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6K13_17905	COG0849	cell division
K6K13_17910	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K6K13_17920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6K13_17925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K6K13_17930	COG0772	Belongs to the SEDS family
K6K13_17935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K6K13_17940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6K13_17945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6K13_17950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K6K13_17955	COG0768	penicillin binding
K6K13_17960	COG3116	cell division
K6K13_17965	COG0275	rRNA processing
K6K13_17990	COG0028	Belongs to the TPP enzyme family
K6K13_18005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6K13_18010	COG0473	3-isopropylmalate dehydrogenase activity
K6K13_18015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K6K13_18020	COG0066	3-isopropylmalate dehydratase activity
K6K13_18030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6K13_18040	COG4533	DNA binding
K6K13_18050	COG1178	ABC-type Fe3 transport system permease component
K6K13_18055	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K6K13_18065	COG0028	Belongs to the TPP enzyme family
K6K13_18070	COG0440	acetolactate synthase activity
K6K13_18080	COG0586	Pfam SNARE associated Golgi protein
K6K13_18120	COG0417	DNA replication proofreading
K6K13_18130	COG0564	pseudouridine synthase activity
K6K13_18135	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K6K13_18140	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K6K13_18145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6K13_18150	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K6K13_18155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6K13_18160	COG2967	ApaG domain
K6K13_18165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K6K13_18170	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K6K13_18175	COG3610	response to peptide
K6K13_18180	COG2966	Psort location CytoplasmicMembrane, score
K6K13_18195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6K13_18210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K6K13_18215	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K6K13_18220	COG1047	Peptidyl-prolyl cis-trans
K6K13_18230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K6K13_18235	COG0196	riboflavin kinase activity
K6K13_18240	COG0268	Binds directly to 16S ribosomal RNA
K6K13_18260	COG0484	heat shock protein binding
K6K13_18265	COG0443	Heat shock 70 kDa protein
K6K13_18270	COG1584	GPR1 FUN34 yaaH family protein
K6K13_18280	COG0521	Mo-molybdopterin cofactor biosynthetic process
K6K13_18285	COG3706	GGDEF domain
K6K13_18290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6K13_18295	COG3022	response to hydroperoxide
K6K13_18305	COG0083	homoserine kinase activity
K6K13_18315	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K6K13_18320	COG0745	RESPONSE REGULATOR receiver
K6K13_18330	COG3045	CreA protein
K6K13_18345	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K6K13_18350	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K6K13_18360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K6K13_18365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K6K13_18370	COG1845	cytochrome c oxidase, subunit III
K6K13_18375	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K6K13_18380	COG0109	protoheme IX farnesyltransferase activity
K6K13_18385	COG2814	Major facilitator Superfamily
K6K13_18390	COG1666	GTP binding
K6K13_18395	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6K13_18400	COG0693	protein deglycase activity
K6K13_18405	COG3077	Addiction module antitoxin, RelB DinJ family
K6K13_18415	COG0301	tRNA thio-modification
K6K13_18415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6K13_18425	COG0142	geranyltranstransferase activity
K6K13_18430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K6K13_18435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K6K13_18440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K6K13_18450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K6K13_18455	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6K13_18455	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6K13_18460	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K6K13_18465	COG4238	major outer membrane lipoprotein
K6K13_18470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6K13_18475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6K13_18480	COG1862	Preprotein translocase
K6K13_18485	COG0343	queuine tRNA-ribosyltransferase activity
K6K13_18490	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6K13_18495	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K6K13_18500	COG0450	alkyl hydroperoxide reductase
K6K13_18505	COG4206	TonB-dependent receptor
K6K13_18530	COG4174	ABC transporter (Permease)
K6K13_18535	COG4239	(ABC) transporter, permease
K6K13_18540	COG4172	Belongs to the ABC transporter superfamily
K6K13_18555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K6K13_18565	COG5002	protein histidine kinase activity
K6K13_18575	COG0420	3'-5' exonuclease activity
K6K13_18580	COG0419	ATPase involved in DNA repair
K6K13_18585	COG1940	carbohydrate kinase activity
K6K13_18590	COG2974	May be involved in recombination
K6K13_18600	COG2076	Multidrug Resistance protein
K6K13_18605	COG2076	Multidrug Resistance protein
K6K13_18615	COG3123	guanosine phosphorylase activity
K6K13_18620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K6K13_18630	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K6K13_18660	COG0246	Mannitol dehydrogenase
K6K13_18665	COG2186	Transcriptional regulator
K6K13_18710	COG2824	Alkylphosphonate utilization operon protein PhnA
K6K13_18715	COG2308	Evidence 4 Homologs of previously reported genes of
K6K13_18725	COG1305	Transglutaminase-like
K6K13_18765	COG1280	lysine exporter protein (LysE YggA)
K6K13_18770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K6K13_18770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6K13_18770	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
K6K13_18775	COG1461	Dihydroxyacetone kinase
K6K13_18780	COG2376	Dihydroxyacetone kinase
K6K13_18785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6K13_18845	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6K13_18930	COG1388	LysM domain
K6K13_18930	COG4932	domain protein
K6K13_18930	COG2373	Large extracellular alpha-helical protein
K6K13_18935	COG0754	glutathionylspermidine amidase activity
K6K13_18950	COG3188	usher protein
K6K13_18970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6K13_18975	COG3015	lipoprotein NlpE involved in copper resistance
K6K13_18980	COG4681	YaeQ
K6K13_18990	COG4568	rho-dependent transcription termination
K6K13_19000	COG0037	tRNA processing
K6K13_19005	COG0346	lactoylglutathione lyase activity
K6K13_19010	COG0825	malonyl-CoA metabolic process
K6K13_19020	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K6K13_19025	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6K13_19030	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6K13_19035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6K13_19040	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6K13_19045	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K6K13_19050	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6K13_19055	COG0750	zinc metalloprotease
K6K13_19060	COG0575	Belongs to the CDS family
K6K13_19065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K6K13_19070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K6K13_19075	COG0233	cytoplasmic translational termination
K6K13_19080	COG0528	UMP kinase activity
K6K13_19085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K6K13_19090	COG0052	Belongs to the universal ribosomal protein uS2 family
K6K13_19100	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K6K13_19105	COG2171	N-acyltransferase activity
K6K13_19125	COG3098	single-species biofilm formation
K6K13_19140	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6K13_19140	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6K13_19145	COG1611	Belongs to the LOG family
K6K13_19150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6K13_19155	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
K6K13_19160	COG2363	Small membrane protein
K6K13_19165	COG0583	DNA-binding transcription factor activity
K6K13_19175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6K13_19180	COG2166	iron-sulfur cluster assembly
K6K13_19185	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K6K13_19205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6K13_19210	COG4172	Belongs to the ABC transporter superfamily
K6K13_19220	COG1473	amidohydrolase
K6K13_19230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6K13_19235	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K6K13_19240	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K6K13_19265	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6K13_19270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K6K13_19270	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K6K13_19285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6K13_19290	COG1074	ATP-dependent DNA helicase activity
K6K13_19300	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K6K13_19315	COG4795	General secretion pathway protein
K6K13_19320	COG2165	general secretion pathway protein
K6K13_19325	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K6K13_19330	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K6K13_19340	COG0494	nUDIX hydrolase
K6K13_19350	COG3066	DNA modification
K6K13_19355	COG0861	Integral membrane protein TerC family
K6K13_19365	COG0667	Aldo Keto reductase
K6K13_19370	COG1028	Short-chain dehydrogenase reductase Sdr
K6K13_19375	COG0753	catalase activity
K6K13_19395	COG3171	Protein conserved in bacteria
K6K13_19400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K6K13_19415	COG0741	lytic transglycosylase activity
K6K13_19425	COG1982	Orn Lys Arg decarboxylase major
K6K13_19440	COG0789	Transcriptional regulator
K6K13_19450	COG0740	serine-type endopeptidase activity
K6K13_19470	COG1263	PTS System
K6K13_19470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K13_19620	COG2205	protein histidine kinase activity
K6K13_19620	COG3437	response regulator, receiver
K6K13_19620	COG3850	Histidine kinase
K6K13_19620	COG4999	Histidine kinase
K6K13_19635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K6K13_19645	COG2986	histidine ammonia-lyase
K6K13_19650	COG1116	anion transmembrane transporter activity
K6K13_19675	COG0402	S-adenosylhomocysteine deaminase activity
K6K13_19680	COG1228	amidohydrolase
K6K13_19695	COG0583	DNA-binding transcription factor activity
K6K13_19710	COG1012	belongs to the aldehyde dehydrogenase family
K6K13_19720	COG1447	Phosphotransferase system cellobiose-specific component IIA
K6K13_19725	COG0583	DNA-binding transcription factor activity
K6K13_19730	COG0473	3-isopropylmalate dehydrogenase activity
K6K13_19740	COG2814	Major facilitator Superfamily
K6K13_19750	COG1802	Transcriptional regulator
K6K13_19755	COG0246	Mannitol dehydrogenase
K6K13_19765	COG1904	glucuronate isomerase
K6K13_19770	COG4948	Mandelate Racemase Muconate Lactonizing
K6K13_19785	COG0437	4 iron, 4 sulfur cluster binding
K6K13_19790	COG3301	Polysulphide reductase, NrfD
K6K13_19795	COG0477	Major facilitator Superfamily
K6K13_19800	COG3976	FMN-binding domain protein
K6K13_19800	COG1053	succinate dehydrogenase
K6K13_19800	COG0431	NADPH-dependent FMN reductase
K6K13_19815	COG2169	Transcriptional regulator
K6K13_19815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6K13_19820	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K6K13_19835	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
K6K13_19835	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K6K13_19845	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6K13_19895	COG3335	DDE superfamily endonuclease
K6K13_19940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K6K13_19945	COG4372	Transposase
K6K13_19950	COG3436	PFAM IS66 Orf2 family protein
K6K13_19980	COG1484	DNA-dependent DNA replication
K6K13_19985	COG4584	PFAM Integrase catalytic
K6K13_20115	COG1045	serine acetyltransferase
K6K13_20120	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K6K13_20125	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K6K13_20130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6K13_20135	COG4942	peptidase
K6K13_20140	COG2861	carbohydrate metabolic process
K6K13_20145	COG1063	alcohol dehydrogenase
K6K13_20150	COG0156	8-amino-7-oxononanoate synthase activity
K6K13_20155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6K13_20160	COG0859	PFAM glycosyl transferase family 9
K6K13_20165	COG0859	PFAM glycosyl transferase family 9
K6K13_20170	COG3307	-O-antigen
K6K13_20175	COG0859	PFAM glycosyl transferase family 9
K6K13_20180	COG0438	transferase activity, transferring glycosyl groups
K6K13_20185	COG0515	serine threonine protein kinase
K6K13_20190	COG0438	transferase activity, transferring glycosyl groups
K6K13_20205	COG4641	Protein conserved in bacteria
K6K13_20205	COG0438	transferase activity, transferring glycosyl groups
K6K13_20220	COG1519	Transferase
K6K13_20225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K6K13_20235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K6K13_20250	COG2003	Belongs to the UPF0758 family
K6K13_20255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K6K13_20260	COG0756	dUTP diphosphatase activity
K6K13_20265	COG1309	transcriptional regulator
K6K13_20270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K6K13_20275	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K6K13_20280	COG4948	Mandelate Racemase Muconate Lactonizing
K6K13_20285	COG4172	Belongs to the ABC transporter superfamily
K6K13_20290	COG0747	negative chemotaxis
K6K13_20295	COG0601	transmembrane transport
K6K13_20300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6K13_20315	COG1446	asparaginase
K6K13_20325	COG4608	Belongs to the ABC transporter superfamily
K6K13_20335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6K13_20340	COG0601	transmembrane transport
K6K13_20345	COG0747	negative chemotaxis
K6K13_20355	COG0583	DNA-binding transcription factor activity
K6K13_20360	COG1561	YicC-like family, N-terminal region
K6K13_20375	COG1470	cell adhesion involved in biofilm formation
K6K13_20375	COG1388	LysM domain
K6K13_20400	COG3969	phosphoadenosine phosphosulfate
K6K13_20405	COG3136	membrane protein required for alginate biosynthesis
K6K13_20415	COG1082	Xylose isomerase domain protein TIM barrel
K6K13_20430	COG0823	Involved in the tonB-independent uptake of proteins
K6K13_20435	COG0673	inositol 2-dehydrogenase activity
K6K13_20450	COG0137	argininosuccinate synthase activity
K6K13_20460	COG1609	Transcriptional regulator
K6K13_20460	COG2207	Transcriptional regulator
K6K13_20465	COG4214	carbohydrate transport
K6K13_20470	COG1129	ABC transporter
K6K13_20475	COG4213	ABC transporter substrate-binding protein
K6K13_20485	COG1070	Carbohydrate kinase
K6K13_20490	COG3274	enterobacterial common antigen metabolic process
K6K13_20500	COG1012	belongs to the aldehyde dehydrogenase family
K6K13_20505	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K6K13_20510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K6K13_20525	COG0246	Mannitol dehydrogenase
K6K13_20530	COG2213	PTS system mannitol-specific
K6K13_20530	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6K13_20550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6K13_20555	COG0751	glycine-tRNA ligase activity
K6K13_20560	COG0752	glycyl-tRNA synthetase alpha subunit
K6K13_20565	COG0730	response to heat
K6K13_20570	COG2818	Glycosylase
K6K13_20575	COG0456	acetyltransferase
K6K13_20580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6K13_20590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6K13_20595	COG0129	dihydroxy-acid dehydratase activity
K6K13_20600	COG2271	Major facilitator Superfamily
K6K13_20605	COG1414	Transcriptional regulator
K6K13_20615	COG1397	ADP-ribosylglycohydrolase
K6K13_20620	COG2188	Transcriptional regulator
K6K13_20625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6K13_20640	COG3977	Valine--pyruvate aminotransferase
K6K13_20665	COG1566	PFAM secretion protein HlyD family protein
K6K13_20670	COG1538	Outer membrane efflux protein
K6K13_20690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6K13_20695	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K6K13_20705	COG0339	signal peptide processing
K6K13_20710	COG0742	ribosomal rna small subunit methyltransferase
K6K13_20715	COG0371	Dehydrogenase
K6K13_20720	COG1129	ABC transporter
K6K13_20725	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6K13_20745	COG0589	response to stress
K6K13_20755	COG0306	phosphate transporter
K6K13_20760	COG2081	HI0933 family
K6K13_20775	COG0697	spore germination
K6K13_20785	COG1773	rubredoxin
K6K13_20785	COG0426	domain, Protein
K6K13_20795	COG0583	DNA-binding transcription factor activity
K6K13_20800	COG2271	Major facilitator Superfamily
K6K13_20805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6K13_20810	COG0473	3-isopropylmalate dehydrogenase activity
K6K13_20810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6K13_20825	COG0604	alcohol dehydrogenase
K6K13_20830	COG1309	transcriptional regulator
K6K13_20845	COG0583	DNA-binding transcription factor activity
K6K13_20880	COG2271	Major facilitator Superfamily
K6K13_20885	COG1840	ABC-type Fe3 transport system, periplasmic component
K6K13_20895	COG3842	ATPase activity
K6K13_20900	COG2200	EAL domain
K6K13_20915	COG2194	sulfuric ester hydrolase activity
K6K13_20925	COG0194	GDP metabolic process
K6K13_20935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6K13_20940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6K13_20945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6K13_20950	COG2233	PERMEase
K6K13_20955	COG2982	Protein involved in outer membrane biogenesis
K6K13_20965	COG1490	D-aminoacyl-tRNA deacylase activity
K6K13_20970	COG1011	Hydrolase
K6K13_20975	COG0583	DNA-binding transcription factor activity
K6K13_20980	COG0477	Major facilitator Superfamily
K6K13_20985	COG1217	gtp-binding protein TYPA
K6K13_21000	COG3852	Histidine kinase
K6K13_21020	COG0811	peptide transport
K6K13_21050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6K13_21060	COG3078	GTPase activator activity
K6K13_21070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6K13_21070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6K13_21075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6K13_21080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6K13_21085	COG3084	Protein conserved in bacteria
K6K13_21090	COG0746	molybdenum cofactor guanylyltransferase activity
K6K13_21095	COG1763	Mo-molybdopterin cofactor biosynthetic process
K6K13_21120	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K6K13_21130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K6K13_21140	COG0551	DNA topoisomerase type I activity
K6K13_21145	COG2922	Belongs to the Smg family
K6K13_21155	COG0242	peptide deformylase activity
K6K13_21160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6K13_21165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K6K13_21165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6K13_21170	COG0569	domain protein
K6K13_21175	COG1970	mechanosensitive ion channel activity
K6K13_21180	COG3036	rescue of stalled ribosome
K6K13_21190	COG0203	ribosomal protein L17
K6K13_21195	COG0202	RNA polymerase activity
K6K13_21200	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K6K13_21215	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6K13_21220	COG0201	protein transport
K6K13_21225	COG0200	Binds to the 23S rRNA
K6K13_21230	COG1841	ribosomal large subunit assembly
K6K13_21250	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K6K13_21255	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K6K13_21260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K6K13_21265	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K6K13_21275	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K6K13_21280	COG0255	Belongs to the universal ribosomal protein uL29 family
K6K13_21285	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K6K13_21290	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K6K13_21295	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K6K13_21300	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K6K13_21305	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K6K13_21310	COG0089	rRNA binding
K6K13_21315	COG0088	Forms part of the polypeptide exit tunnel
K6K13_21320	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6K13_21325	COG0051	transcription antitermination factor activity, RNA binding
K6K13_21345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6K13_21355	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K6K13_21360	COG2168	tRNA wobble position uridine thiolation
K6K13_21365	COG2923	Belongs to the DsrF TusC family
K6K13_21370	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K6K13_21375	COG2964	Protein conserved in bacteria
K6K13_21385	COG0745	RESPONSE REGULATOR receiver
K6K13_21390	COG0642	Histidine kinase
K6K13_21395	COG0545	Peptidyl-prolyl cis-trans isomerase
K6K13_21400	COG2900	Belongs to the SlyX family
K6K13_21405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6K13_21410	COG1609	Transcriptional regulator
K6K13_21415	COG0840	transmembrane signaling receptor activity
K6K13_21425	COG0477	Major facilitator Superfamily
K6K13_21430	COG1047	Peptidyl-prolyl cis-trans
K6K13_21435	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
K6K13_21440	COG0475	glutathione-regulated potassium exporter activity
K6K13_21440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6K13_21445	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6K13_21450	COG0488	(ABC) transporter
K6K13_21460	COG0429	hydrolase of the alpha beta-hydrolase fold
K6K13_21465	COG3089	Belongs to the UPF0270 family
K6K13_21470	COG3954	Phosphoribulokinase
K6K13_21475	COG1765	OsmC-like protein
K6K13_21495	COG3397	chitin binding
K6K13_21510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6K13_21515	COG4608	Belongs to the ABC transporter superfamily
K6K13_21520	COG0444	Belongs to the ABC transporter superfamily
K6K13_21525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6K13_21535	COG0747	negative chemotaxis
K6K13_21540	COG4948	Mandelate Racemase Muconate Lactonizing
K6K13_21565	COG1473	amidohydrolase
K6K13_21570	COG1280	lysine exporter protein (LysE YggA)
K6K13_21575	COG0180	Tryptophanyl-tRNA synthetase
K6K13_21580	COG0546	phosphoglycolate phosphatase activity
K6K13_21585	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K6K13_21600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K6K13_21605	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K6K13_21610	COG4796	Type ii and iii secretion system protein
K6K13_21635	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K6K13_21640	COG0494	nUDIX hydrolase
K6K13_21650	COG1011	Hydrolase
K6K13_21660	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K6K13_21665	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K6K13_21680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6K13_21705	COG2183	response to ionizing radiation
K6K13_21725	COG1136	(ABC) transporter
K6K13_21735	COG1785	Belongs to the alkaline phosphatase family
K6K13_21745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6K13_21750	COG2267	carboxylic ester hydrolase activity
K6K13_21755	COG1040	competence protein
K6K13_21760	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K6K13_21760	COG0316	Belongs to the HesB IscA family
K6K13_21765	COG1640	4-alpha-glucanotransferase
K6K13_21775	COG1349	DNA-binding transcription factor activity
K6K13_21780	COG0705	Rhomboid family
K6K13_21785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6K13_21790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6K13_21795	COG2271	Major facilitator Superfamily
K6K13_21800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6K13_21830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6K13_21850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K6K13_21855	COG0437	4 iron, 4 sulfur cluster binding
K6K13_21860	COG2414	aldehyde ferredoxin oxidoreductase
K6K13_21870	COG0437	4 iron, 4 sulfur cluster binding
K6K13_21900	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6K13_21905	COG0058	SHG alpha-glucan phosphorylase activity
K6K13_21920	COG1523	belongs to the glycosyl hydrolase 13 family
K6K13_21925	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K6K13_21930	COG3275	phosphorelay sensor kinase activity
K6K13_21940	COG0601	transmembrane transport
K6K13_21945	COG0747	negative chemotaxis
K6K13_21950	COG2226	methyltransferase
K6K13_21950	COG1073	alpha beta
K6K13_21955	COG0864	Transcriptional regulator
K6K13_21970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6K13_21975	COG2095	MarC family integral membrane protein
K6K13_21990	COG1741	Belongs to the pirin family
K6K13_21995	COG0247	lactate metabolic process
K6K13_22000	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
K6K13_22005	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K6K13_22010	COG2271	Major facilitator Superfamily
K6K13_22015	COG0561	phosphatase activity
K6K13_22020	COG2267	carboxylic ester hydrolase activity
K6K13_22025	COG1280	lysine exporter protein (LysE YggA)
K6K13_22030	COG1280	lysine exporter protein (LysE YggA)
K6K13_22035	COG0514	ATP-dependent DNA helicase (RecQ)
K6K13_22045	COG2050	protein possibly involved in aromatic compounds catabolism
K6K13_22055	COG3180	Ammonia monooxygenase
K6K13_22060	COG0598	Magnesium transport protein CorA
K6K13_22070	COG0210	DNA helicase
K6K13_22075	COG1011	Hydrolase
K6K13_22090	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K6K13_22110	COG0181	hydroxymethylbilane synthase activity
K6K13_22115	COG1587	Uroporphyrinogen-III synthase
K6K13_22120	COG2959	enzyme of heme biosynthesis
K6K13_22125	COG3071	HemY protein
K6K13_22130	COG2723	6-phospho-beta-galactosidase activity
K6K13_22150	COG1126	abc transporter atp-binding protein
K6K13_22155	COG0765	amino acid transport
K6K13_22160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6K13_22165	COG0456	acetyltransferase
K6K13_22175	COG0371	Dehydrogenase
K6K13_22180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6K13_22205	COG1113	amino acid transport
K6K13_22210	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K6K13_22220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K6K13_22225	COG2244	polysaccharide biosynthetic process
K6K13_22230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6K13_22235	COG0456	acetyltransferase
K6K13_22240	COG1088	dTDP-glucose 4,6-dehydratase activity
K6K13_22245	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K6K13_22250	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K6K13_22260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6K13_22265	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K6K13_22270	COG3118	belongs to the thioredoxin family
K6K13_22280	COG0248	Ppx GppA phosphatase
K6K13_22290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6K13_22305	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K6K13_22310	COG0583	DNA-binding transcription factor activity
K6K13_22315	COG4774	siderophore transport
K6K13_22335	COG0129	dihydroxy-acid dehydratase activity
K6K13_22340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6K13_22345	COG3978	acetolactate synthase activity
K6K13_22365	COG3085	chromosome segregation
K6K13_22370	COG0583	DNA-binding transcription factor activity
K6K13_22375	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6K13_22380	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6K13_22390	COG1879	ABC-type sugar transport system periplasmic component
K6K13_22420	COG0138	bifunctional purine biosynthesis protein purh
K6K13_22445	COG1515	deoxyribonuclease V activity
K6K13_22450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K6K13_22455	COG2816	NAD+ diphosphatase activity
K6K13_22460	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K6K13_22465	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K6K13_22470	COG0352	thiamine-phosphate diphosphorylase activity
K6K13_22475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6K13_22480	COG2104	thiamine diphosphate biosynthetic process
K6K13_22485	COG2022	thiamine diphosphate biosynthetic process
K6K13_22495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6K13_22505	COG4191	Histidine kinase
K6K13_22510	COG4566	intracellular signal transduction
K6K13_22525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K6K13_22530	COG0085	RNA polymerase activity
K6K13_22550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K6K13_22555	COG0250	Participates in transcription elongation, termination and antitermination
K6K13_22595	COG1072	(Pantothenic acid kinase))
K6K13_22630	COG1609	Transcriptional regulator
K6K13_22635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6K13_22640	COG1879	ABC-type sugar transport system periplasmic component
K6K13_22645	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6K13_22650	COG1129	ABC transporter
K6K13_22655	COG1869	D-ribose catabolic process
K6K13_22665	COG3158	transport of potassium into the cell
K6K13_22670	COG0714	Associated with various cellular activities
K6K13_22675	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K6K13_22680	COG2502	aspartate--ammonia ligase
K6K13_22685	COG1522	sequence-specific DNA binding
K6K13_22690	COG0716	FMN binding
K6K13_22695	COG0445	tRNA wobble uridine modification
K6K13_22700	COG0357	Ribosomal RNA small subunit methyltransferase G
K6K13_22705	COG3312	ion transport
K6K13_22710	COG0356	it plays a direct role in the translocation of protons across the membrane
K6K13_22720	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K6K13_22730	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K6K13_22735	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K6K13_22740	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K6K13_22745	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K6K13_22760	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K6K13_22765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K6K13_22785	COG0204	Acyl-transferase
K6K13_22785	COG0318	PFAM AMP-dependent synthetase and ligase
K6K13_22795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6K13_22810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6K13_22815	COG1216	Glycosyl transferase, family 2
K6K13_22840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6K13_22870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K6K13_22875	COG0573	inorganic phosphate transmembrane transporter activity
K6K13_22880	COG0581	inorganic phosphate transmembrane transporter activity
K6K13_22885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6K13_22910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6K13_22915	COG0765	amino acid transport
K6K13_22920	COG0765	amino acid transport
K6K13_22925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6K13_22930	COG2252	PERMEase
K6K13_22940	COG0493	'glutamate synthase
K6K13_22940	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6K13_22965	COG1181	Belongs to the D-alanine--D-alanine ligase family
K6K13_22975	COG1349	DNA-binding transcription factor activity
K6K13_22985	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K6K13_22990	COG0706	membrane insertase activity
K6K13_22995	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K6K13_23000	COG0594	ribonuclease P activity
K6K13_23005	COG0230	Belongs to the bacterial ribosomal protein bL34 family