locus-tag	class	description
Mal52_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Mal52_00020	COG0592	DNA-directed DNA polymerase activity
Mal52_00040	COG0187	DNA topoisomerase II activity
Mal52_00050	COG2084	Dehydrogenase
Mal52_00060	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_00100	COG0515	serine threonine protein kinase
Mal52_00100	COG2815	serine threonine protein kinase
Mal52_00120	COG0590	tRNA wobble adenosine to inosine editing
Mal52_00230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Mal52_00240	COG3494	Protein of unknown function (DUF1009)
Mal52_00250	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Mal52_00300	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Mal52_00340	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_00580	COG0598	Magnesium transport protein CorA
Mal52_00590	COG0473	3-isopropylmalate dehydrogenase activity
Mal52_00600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Mal52_00610	COG2890	protein-(glutamine-N5) methyltransferase activity
Mal52_00620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Mal52_00630	COG0254	rRNA binding
Mal52_00670	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_00720	COG0515	serine threonine protein kinase
Mal52_00720	COG2815	serine threonine protein kinase
Mal52_00730	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Mal52_00750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Mal52_00860	COG2204	response regulator
Mal52_00890	COG1677	Flagellar hook-basal body complex protein FliE
Mal52_00910	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Mal52_00930	COG1157	protein secretion by the type III secretion system
Mal52_00970	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Mal52_01010	COG1360	Flagellar Motor Protein
Mal52_01030	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Mal52_01030	COG1776	CheC inhibitor of MCP methylation
Mal52_01050	COG1338	Plays a role in the flagellum-specific transport system
Mal52_01060	COG1987	bacterial-type flagellum assembly
Mal52_01080	COG1684	flagellar biosynthetic protein fliR
Mal52_01090	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Mal52_01120	COG5002	protein histidine kinase activity
Mal52_01120	COG2205	protein histidine kinase activity
Mal52_01120	COG0784	Response regulator, receiver
Mal52_01200	COG1376	ErfK ybiS ycfS ynhG family protein
Mal52_01220	COG0673	inositol 2-dehydrogenase activity
Mal52_01240	COG1943	Transposase
Mal52_01260	COG0714	Associated with various cellular activities
Mal52_01360	COG1515	deoxyribonuclease V activity
Mal52_01370	COG2199	diguanylate cyclase activity
Mal52_01370	COG2200	EAL domain
Mal52_01370	COG3287	FIST C domain
Mal52_01410	COG0515	serine threonine protein kinase
Mal52_01410	COG2815	serine threonine protein kinase
Mal52_01440	COG2154	pterin-4-alpha-carbinolamine dehydratase
Mal52_01450	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_01490	COG0617	tRNA 3'-terminal CCA addition
Mal52_01490	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Mal52_01490	COG0517	IMP dehydrogenase activity
Mal52_01500	COG0039	L-malate dehydrogenase activity
Mal52_01810	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_01830	COG1862	Preprotein translocase
Mal52_01840	COG0343	queuine tRNA-ribosyltransferase activity
Mal52_01890	COG4536	flavin adenine dinucleotide binding
Mal52_01920	COG0142	geranyltranstransferase activity
Mal52_01960	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Mal52_01970	COG0174	glutamine synthetase
Mal52_02000	COG0004	ammonium transporteR
Mal52_02020	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Mal52_02030	COG0616	signal peptide processing
Mal52_02040	COG0598	Magnesium transport protein CorA
Mal52_02050	COG4067	protein conserved in archaea
Mal52_02050	COG0189	ligase activity
Mal52_02060	COG0569	domain protein
Mal52_02060	COG0189	ligase activity
Mal52_02100	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Mal52_02120	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_02130	COG1597	lipid kinase activity
Mal52_02140	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Mal52_02160	COG3119	arylsulfatase activity
Mal52_02300	COG1560	Kdo2-lipid A biosynthetic process
Mal52_02360	COG0714	Associated with various cellular activities
Mal52_02410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Mal52_02420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Mal52_02470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Mal52_02480	COG0626	cystathionine gamma-synthase activity
Mal52_02490	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_02500	COG0205	6-phosphofructokinase activity
Mal52_02510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_02540	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Mal52_02550	COG0287	Prephenate dehydrogenase
Mal52_02560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Mal52_02640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Mal52_02650	COG2226	methyltransferase
Mal52_02680	COG0577	efflux transmembrane transporter activity
Mal52_02680	COG1136	(ABC) transporter
Mal52_02770	COG3022	response to hydroperoxide
Mal52_02810	COG0537	adenosine 5'-monophosphoramidase activity
Mal52_02830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Mal52_02870	COG0058	SHG alpha-glucan phosphorylase activity
Mal52_02880	COG0649	NAD binding
Mal52_02890	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mal52_02900	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mal52_02930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Mal52_03070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Mal52_03100	COG0010	Belongs to the arginase family
Mal52_03120	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
Mal52_03120	COG0028	Belongs to the TPP enzyme family
Mal52_03180	COG1459	type II secretion system
Mal52_03190	COG1459	type II secretion system
Mal52_03210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_03220	COG0545	Peptidyl-prolyl cis-trans isomerase
Mal52_03270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Mal52_03300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Mal52_03310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Mal52_03360	COG1725	Transcriptional regulator
Mal52_03370	COG1131	(ABC) transporter
Mal52_03450	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Mal52_03460	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Mal52_03480	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Mal52_03510	COG0067	glutamate synthase
Mal52_03510	COG0070	glutamate synthase
Mal52_03510	COG0069	glutamate synthase activity
Mal52_03520	COG0493	'glutamate synthase
Mal52_03540	COG0129	dihydroxy-acid dehydratase activity
Mal52_03560	COG2208	phosphoserine phosphatase activity
Mal52_03560	COG2770	Histidine kinase
Mal52_03690	COG3206	protein involved in exopolysaccharide biosynthesis
Mal52_03690	COG0489	protein tyrosine kinase activity
Mal52_03710	COG0726	polysaccharide deacetylase
Mal52_03740	COG0438	transferase activity, transferring glycosyl groups
Mal52_03770	COG0438	transferase activity, transferring glycosyl groups
Mal52_03800	COG0438	transferase activity, transferring glycosyl groups
Mal52_03810	COG0367	asparagine synthase
Mal52_03820	COG1215	transferase activity, transferring glycosyl groups
Mal52_03830	COG1216	Glycosyl transferase, family 2
Mal52_03860	COG0463	Glycosyl transferase, family 2
Mal52_03870	COG3394	polysaccharide catabolic process
Mal52_03940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Mal52_03950	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Mal52_03960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Mal52_04000	COG4956	integral membrane protein (PIN domain superfamily)
Mal52_04070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Mal52_04080	COG0187	DNA topoisomerase II activity
Mal52_04130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Mal52_04160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Mal52_04180	COG0750	zinc metalloprotease
Mal52_04190	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Mal52_04250	COG1082	Xylose isomerase domain protein TIM barrel
Mal52_04270	COG0788	formyltetrahydrofolate deformylase activity
Mal52_04300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Mal52_04360	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Mal52_04380	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Mal52_04390	COG0328	RNA-DNA hybrid ribonuclease activity
Mal52_04400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Mal52_04420	COG1295	ribonuclease BN
Mal52_04510	COG3119	arylsulfatase activity
Mal52_04520	COG3119	arylsulfatase activity
Mal52_04550	COG2815	serine threonine protein kinase
Mal52_04550	COG0515	serine threonine protein kinase
Mal52_04600	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_04630	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Mal52_04700	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Mal52_04770	COG3119	arylsulfatase activity
Mal52_04800	COG0584	glycerophosphoryl diester phosphodiesterase
Mal52_04880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Mal52_04890	COG2116	formate transmembrane transporter activity
Mal52_04900	COG2217	Heavy metal translocating P-type atpase
Mal52_04950	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Mal52_04970	COG1846	Transcriptional regulator
Mal52_05000	COG3119	arylsulfatase activity
Mal52_05050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Mal52_05060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Mal52_05070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Mal52_05080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Mal52_05150	COG0443	Heat shock 70 kDa protein
Mal52_05260	COG2198	Histidine kinase
Mal52_05260	COG5002	protein histidine kinase activity
Mal52_05260	COG0784	Response regulator, receiver
Mal52_05280	COG2234	aminopeptidase activity
Mal52_05300	COG1674	ftsk spoiiie
Mal52_05350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Mal52_05360	COG0581	inorganic phosphate transmembrane transporter activity
Mal52_05370	COG0573	inorganic phosphate transmembrane transporter activity
Mal52_05380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Mal52_05390	COG1283	sodium-dependent phosphate transmembrane transporter activity
Mal52_05410	COG0489	protein tyrosine kinase activity
Mal52_05420	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Mal52_05430	COG0159	tryptophan synthase activity
Mal52_05440	COG2738	Putative neutral zinc metallopeptidase
Mal52_05520	COG2890	protein-(glutamine-N5) methyltransferase activity
Mal52_05530	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_05550	COG0673	inositol 2-dehydrogenase activity
Mal52_05570	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Mal52_05600	COG1073	alpha beta
Mal52_05620	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Mal52_05690	COG3119	arylsulfatase activity
Mal52_05780	COG1643	Atp-dependent helicase
Mal52_05800	COG2414	aldehyde ferredoxin oxidoreductase
Mal52_05830	COG1509	lysine 2,3-aminomutase activity
Mal52_05840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Mal52_05930	COG1940	carbohydrate kinase activity
Mal52_05990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Mal52_06000	COG1132	(ABC) transporter
Mal52_06090	COG0482	sulfurtransferase activity
Mal52_06110	COG1196	nuclear chromosome segregation
Mal52_06140	COG1649	PFAM Uncharacterised BCR, COG1649
Mal52_06140	COG0726	polysaccharide deacetylase
Mal52_06150	COG2204	response regulator
Mal52_06170	COG1007	ATP synthesis coupled electron transport
Mal52_06190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Mal52_06190	COG2111	Na H antiporter
Mal52_06310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Mal52_06330	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Mal52_06360	COG0156	8-amino-7-oxononanoate synthase activity
Mal52_06370	COG1063	alcohol dehydrogenase
Mal52_06460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Mal52_06460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Mal52_06520	COG0284	orotidine-5'-phosphate decarboxylase activity
Mal52_06540	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Mal52_06550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Mal52_06560	COG2239	Acts as a magnesium transporter
Mal52_06590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Mal52_06620	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Mal52_06650	COG0302	gtp cyclohydrolase
Mal52_06690	COG1321	iron dependent repressor
Mal52_06700	COG0803	Belongs to the bacterial solute-binding protein 9 family
Mal52_06710	COG1121	(ABC) transporter
Mal52_06720	COG1321	iron dependent repressor
Mal52_06720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Mal52_06740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Mal52_06760	COG0552	protein localization to endoplasmic reticulum
Mal52_06830	COG0196	riboflavin kinase activity
Mal52_06840	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Mal52_06860	COG1104	cysteine desulfurase activity
Mal52_06890	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Mal52_06900	COG1805	sodium ion transport
Mal52_06920	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Mal52_06930	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Mal52_06940	COG2871	sodium ion transport
Mal52_06950	COG1477	protein flavinylation
Mal52_06960	COG0579	oxidoreductase
Mal52_06970	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Mal52_07000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Mal52_07010	COG1668	transmembrane transport
Mal52_07020	COG1131	(ABC) transporter
Mal52_07030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Mal52_07040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Mal52_07090	COG0047	phosphoribosylformylglycinamidine synthase activity
Mal52_07140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Mal52_07170	COG1530	ribonuclease E activity
Mal52_07180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Mal52_07280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Mal52_07290	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Mal52_07310	COG0314	molybdopterin synthase activity
Mal52_07410	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Mal52_07430	COG3119	arylsulfatase activity
Mal52_07430	COG3408	Glycogen debranching enzyme
Mal52_07440	COG0531	amino acid
Mal52_07460	COG0069	glutamate synthase activity
Mal52_07520	COG1030	water channel activity
Mal52_07530	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Mal52_07540	COG0594	ribonuclease P activity
Mal52_07550	COG1136	(ABC) transporter
Mal52_07560	COG1136	(ABC) transporter
Mal52_07560	COG0577	efflux transmembrane transporter activity
Mal52_07570	COG0484	heat shock protein binding
Mal52_07620	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Mal52_07630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mal52_07650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Mal52_07660	COG0138	bifunctional purine biosynthesis protein purh
Mal52_07680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Mal52_07690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mal52_07700	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_07830	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Mal52_07860	COG3119	arylsulfatase activity
Mal52_07890	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Mal52_07910	COG0514	ATP-dependent DNA helicase (RecQ)
Mal52_07940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Mal52_08000	COG2814	Major facilitator Superfamily
Mal52_08030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Mal52_08120	COG1573	uracil-dna glycosylase
Mal52_08200	COG2169	Transcriptional regulator
Mal52_08200	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Mal52_08240	COG0387	Pfam Sodium calcium exchanger
Mal52_08260	COG0038	chloride channel
Mal52_08280	COG0584	glycerophosphoryl diester phosphodiesterase
Mal52_08410	COG2912	Transglutaminase-like superfamily
Mal52_08430	COG0740	serine-type endopeptidase activity
Mal52_08440	COG0740	serine-type endopeptidase activity
Mal52_08450	COG0544	peptidyl-prolyl cis-trans isomerase activity
Mal52_08470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Mal52_08480	COG0822	iron-sulfur transferase activity
Mal52_08510	COG1611	Belongs to the LOG family
Mal52_08520	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Mal52_08590	COG1216	Glycosyl transferase, family 2
Mal52_08660	COG0714	Associated with various cellular activities
Mal52_08680	COG3177	Filamentation induced by cAMP protein fic
Mal52_08740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Mal52_08750	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Mal52_08760	COG0228	four-way junction DNA binding
Mal52_08770	COG0336	Belongs to the RNA methyltransferase TrmD family
Mal52_08780	COG0335	large ribosomal subunit rRNA binding
Mal52_08790	COG0792	nuclease activity
Mal52_08810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Mal52_08900	COG1690	Belongs to the RtcB family
Mal52_08980	COG0583	DNA-binding transcription factor activity
Mal52_09040	COG3119	arylsulfatase activity
Mal52_09100	COG3119	arylsulfatase activity
Mal52_09110	COG3119	arylsulfatase activity
Mal52_09130	COG2201	protein-glutamate methylesterase activity
Mal52_09210	COG1253	flavin adenine dinucleotide binding
Mal52_09280	COG3119	arylsulfatase activity
Mal52_09540	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Mal52_09600	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Mal52_09620	COG1199	ATP-dependent helicase activity
Mal52_09680	COG1192	Involved in chromosome partitioning
Mal52_09720	COG0167	dihydroorotate dehydrogenase activity
Mal52_09780	COG0395	ABC-type sugar transport system, permease component
Mal52_09840	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Mal52_09870	COG1301	dicarboxylic acid transport
Mal52_09880	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Mal52_09950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Mal52_10000	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Mal52_10020	COG5492	domain, Protein
Mal52_10020	COG4932	domain protein
Mal52_10060	COG1132	(ABC) transporter
Mal52_10070	COG0390	transport system, permease component
Mal52_10080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Mal52_10130	COG3119	arylsulfatase activity
Mal52_10160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Mal52_10190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Mal52_10200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Mal52_10210	COG1555	photosystem II stabilization
Mal52_10210	COG1596	polysaccharide export
Mal52_10260	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Mal52_10290	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Mal52_10300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Mal52_10310	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Mal52_10330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Mal52_10340	COG0601	transmembrane transport
Mal52_10350	COG0747	negative chemotaxis
Mal52_10370	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Mal52_10370	COG0456	acetyltransferase
Mal52_10390	COG0473	3-isopropylmalate dehydrogenase activity
Mal52_10590	COG3119	arylsulfatase activity
Mal52_10700	COG0488	(ABC) transporter
Mal52_10780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Mal52_10790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Mal52_10800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Mal52_10810	COG0405	Gamma-glutamyltransferase
Mal52_10830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Mal52_10900	COG1570	exodeoxyribonuclease VII activity
Mal52_10950	COG0714	Associated with various cellular activities
Mal52_10980	COG1174	glycine betaine transport
Mal52_10990	COG1125	glycine betaine transport
Mal52_10990	COG0517	IMP dehydrogenase activity
Mal52_11010	COG0513	Belongs to the DEAD box helicase family
Mal52_11250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Mal52_11310	COG3118	belongs to the thioredoxin family
Mal52_11330	COG0483	inositol monophosphate 1-phosphatase activity
Mal52_11340	COG0175	sulfate reduction
Mal52_11350	COG0515	serine threonine protein kinase
Mal52_11350	COG2815	serine threonine protein kinase
Mal52_11370	COG0793	Belongs to the peptidase S41A family
Mal52_11390	COG1454	alcohol dehydrogenase
Mal52_11490	COG0330	HflC and HflK could
Mal52_11500	COG0330	HflC and HflK could
Mal52_11510	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Mal52_11520	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Mal52_11530	COG4555	ABC transporter
Mal52_11540	COG1668	transmembrane transport
Mal52_11590	COG3842	ATPase activity
Mal52_11670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Mal52_11720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mal52_11740	COG1175	transmembrane transport
Mal52_11790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Mal52_11820	COG1774	PSP1 C-terminal conserved region
Mal52_11930	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Mal52_11940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mal52_11960	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Mal52_11990	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Mal52_12000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Mal52_12100	COG0714	Associated with various cellular activities
Mal52_12170	COG3258	Cytochrome c
Mal52_12200	COG0446	pyridine nucleotide-disulphide oxidoreductase
Mal52_12210	COG2427	Protein of unknown function (DUF1641)
Mal52_12220	COG0450	alkyl hydroperoxide reductase
Mal52_12350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Mal52_12370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Mal52_12390	COG1045	serine acetyltransferase
Mal52_12400	COG0463	Glycosyl transferase, family 2
Mal52_12500	COG0297	glycogen (starch) synthase activity
Mal52_12510	COG1215	transferase activity, transferring glycosyl groups
Mal52_12660	COG0745	RESPONSE REGULATOR receiver
Mal52_12700	COG0673	inositol 2-dehydrogenase activity
Mal52_12710	COG0714	Associated with various cellular activities
Mal52_12770	COG0436	Aminotransferase
Mal52_12800	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Mal52_12810	COG0166	Belongs to the GPI family
Mal52_12820	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Mal52_12830	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Mal52_12860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Mal52_12880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mal52_12960	COG0702	epimerase
Mal52_13040	COG1253	flavin adenine dinucleotide binding
Mal52_13080	COG1331	Highly conserved protein containing a thioredoxin domain
Mal52_13110	COG0723	plastoquinol--plastocyanin reductase activity
Mal52_13110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mal52_13190	COG1796	DNA polymerase
Mal52_13190	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Mal52_13200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mal52_13210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Mal52_13290	COG0644	oxidoreductase
Mal52_13420	COG0358	DNA primase activity
Mal52_13610	COG4974	Belongs to the 'phage' integrase family
Mal52_13760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Mal52_14020	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Mal52_14070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Mal52_14080	COG2267	carboxylic ester hydrolase activity
Mal52_14100	COG0800	Aldolase
Mal52_14110	COG0784	Response regulator, receiver
Mal52_14120	COG4251	negative regulation of phosphorylation
Mal52_14130	COG1285	pathogenesis
Mal52_14190	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Mal52_14270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Mal52_14320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Mal52_14340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Mal52_14350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_14360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Mal52_14380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Mal52_14390	COG0515	serine threonine protein kinase
Mal52_14430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Mal52_14440	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Mal52_14460	COG0107	imidazoleglycerol-phosphate synthase activity
Mal52_14480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_14510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Mal52_14510	COG0519	Catalyzes the synthesis of GMP from XMP
Mal52_14560	COG0583	DNA-binding transcription factor activity
Mal52_14640	COG5002	protein histidine kinase activity
Mal52_14680	COG4251	negative regulation of phosphorylation
Mal52_14690	COG0784	Response regulator, receiver
Mal52_14840	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Mal52_14860	COG1201	RNA secondary structure unwinding
Mal52_14870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Mal52_14930	COG0275	rRNA processing
Mal52_14960	COG0564	pseudouridine synthase activity
Mal52_14980	COG0673	inositol 2-dehydrogenase activity
Mal52_15030	COG2115	Belongs to the xylose isomerase family
Mal52_15050	COG1082	Xylose isomerase domain protein TIM barrel
Mal52_15060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Mal52_15120	COG3385	transposase activity
Mal52_15160	COG3118	belongs to the thioredoxin family
Mal52_15210	COG0616	signal peptide processing
Mal52_15350	COG1082	Xylose isomerase domain protein TIM barrel
Mal52_15360	COG4786	Flagellar basal body rod
Mal52_15370	COG4786	Flagellar basal body rod
Mal52_15390	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Mal52_15400	COG1706	bacterial-type flagellum-dependent cell motility
Mal52_15430	COG1256	bacterial-type flagellum assembly
Mal52_15430	COG4786	Flagellar basal body rod
Mal52_15440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Mal52_15510	COG3119	arylsulfatase activity
Mal52_15590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Mal52_15640	COG2308	Evidence 4 Homologs of previously reported genes of
Mal52_15700	COG2204	response regulator
Mal52_15710	COG3852	Histidine kinase
Mal52_15720	COG0288	reversible hydration of carbon dioxide
Mal52_15730	COG0667	Aldo Keto reductase
Mal52_15740	COG3119	arylsulfatase activity
Mal52_15760	COG4191	Histidine kinase
Mal52_15790	COG0673	inositol 2-dehydrogenase activity
Mal52_15850	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_15860	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Mal52_15910	COG0811	peptide transport
Mal52_15940	COG0517	IMP dehydrogenase activity
Mal52_15940	COG0516	GMP reductase activity
Mal52_15950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Mal52_15960	COG0307	riboflavin synthase, alpha
Mal52_15990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Mal52_16010	COG1331	Highly conserved protein containing a thioredoxin domain
Mal52_16020	COG0673	inositol 2-dehydrogenase activity
Mal52_16030	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Mal52_16080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Mal52_16090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Mal52_16100	COG0673	inositol 2-dehydrogenase activity
Mal52_16120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Mal52_16130	COG0131	Imidazoleglycerol-phosphate dehydratase
Mal52_16160	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Mal52_16170	COG1012	belongs to the aldehyde dehydrogenase family
Mal52_16200	COG0604	alcohol dehydrogenase
Mal52_16220	COG3119	arylsulfatase activity
Mal52_16230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Mal52_16260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Mal52_16310	COG0475	glutathione-regulated potassium exporter activity
Mal52_16320	COG2815	serine threonine protein kinase
Mal52_16320	COG0515	serine threonine protein kinase
Mal52_16410	COG0768	penicillin binding
Mal52_16480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Mal52_16490	COG0187	DNA topoisomerase II activity
Mal52_16500	COG3119	arylsulfatase activity
Mal52_16510	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Mal52_16530	COG0402	S-adenosylhomocysteine deaminase activity
Mal52_16600	COG3119	arylsulfatase activity
Mal52_16610	COG1024	Enoyl-CoA hydratase
Mal52_16660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_16670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mal52_16680	COG0165	Argininosuccinate lyase
Mal52_16710	COG0515	serine threonine protein kinase
Mal52_16710	COG2815	serine threonine protein kinase
Mal52_16810	COG0704	Plays a role in the regulation of phosphate uptake
Mal52_16830	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Mal52_16840	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Mal52_16880	COG1040	competence protein
Mal52_16900	COG0181	hydroxymethylbilane synthase activity
Mal52_17050	COG0148	phosphopyruvate hydratase activity
Mal52_17060	COG0688	phosphatidylethanolamine metabolic process
Mal52_17070	COG1183	phosphatidylcholine synthase activity
Mal52_17090	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Mal52_17090	COG0493	'glutamate synthase
Mal52_17100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Mal52_17160	COG1222	aaa ATPase
Mal52_17200	COG0009	L-threonylcarbamoyladenylate synthase
Mal52_17230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Mal52_17280	COG3119	arylsulfatase activity
Mal52_17290	COG0508	dehydrogenase complex catalyzes the overall conversion of
Mal52_17420	COG0515	serine threonine protein kinase
Mal52_17420	COG2815	serine threonine protein kinase
Mal52_17450	COG1477	protein flavinylation
Mal52_17460	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Mal52_17530	COG3228	Belongs to the MtfA family
Mal52_17610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Mal52_17630	COG0151	Belongs to the GarS family
Mal52_17810	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Mal52_17870	COG2211	Major facilitator Superfamily
Mal52_17920	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Mal52_17990	COG2095	MarC family integral membrane protein
Mal52_18070	COG0515	serine threonine protein kinase
Mal52_18070	COG2815	serine threonine protein kinase
Mal52_18120	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Mal52_18170	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mal52_18210	COG3119	arylsulfatase activity
Mal52_18280	COG1131	(ABC) transporter
Mal52_18300	COG0714	Associated with various cellular activities
Mal52_18330	COG1091	dTDP-4-dehydrorhamnose reductase activity
Mal52_18350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Mal52_18350	COG4106	trans-aconitate 2-methyltransferase activity
Mal52_18410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Mal52_18450	COG2226	methyltransferase
Mal52_18460	COG3956	TIGRFAM MazG family protein
Mal52_18470	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Mal52_18480	COG0539	negative regulation of cytoplasmic translation
Mal52_18490	COG2195	Cleaves the N-terminal amino acid of tripeptides
Mal52_18540	COG3119	arylsulfatase activity
Mal52_18630	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_18740	COG0326	Molecular chaperone. Has ATPase activity
Mal52_18780	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
Mal52_18790	COG0189	ligase activity
Mal52_18820	COG1073	alpha beta
Mal52_18850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Mal52_18890	COG2255	four-way junction helicase activity
Mal52_18970	COG3540	Alkaline phosphatase
Mal52_19330	COG3119	arylsulfatase activity
Mal52_19350	COG0617	tRNA 3'-terminal CCA addition
Mal52_19350	COG0517	IMP dehydrogenase activity
Mal52_19350	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Mal52_19580	COG1657	PFAM Prenyltransferase squalene oxidase
Mal52_19620	COG1129	ABC transporter
Mal52_19640	COG3386	PFAM SMP-30 Gluconolaconase
Mal52_19700	COG3706	GGDEF domain
Mal52_19720	COG0129	dihydroxy-acid dehydratase activity
Mal52_19730	COG1858	cytochrome C peroxidase
Mal52_19750	COG0784	Response regulator, receiver
Mal52_19780	COG2818	Glycosylase
Mal52_19880	COG2205	protein histidine kinase activity
Mal52_19880	COG3437	response regulator, receiver
Mal52_19880	COG3850	Histidine kinase
Mal52_19880	COG4999	Histidine kinase
Mal52_19900	COG2204	response regulator
Mal52_19920	COG0515	serine threonine protein kinase
Mal52_19930	COG1012	belongs to the aldehyde dehydrogenase family
Mal52_20000	COG0512	Glutamine amidotransferase of anthranilate synthase
Mal52_20000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Mal52_20030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Mal52_20060	COG1595	DNA-templated transcription, initiation
Mal52_20090	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_20100	COG0443	Heat shock 70 kDa protein
Mal52_20120	COG0205	6-phosphofructokinase activity
Mal52_20140	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Mal52_20160	COG1234	tRNA 3'-trailer cleavage
Mal52_20170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Mal52_20180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Mal52_20190	COG3119	arylsulfatase activity
Mal52_20240	COG0714	Associated with various cellular activities
Mal52_20340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Mal52_20360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Mal52_20370	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_20380	COG1070	Carbohydrate kinase
Mal52_20470	COG3119	arylsulfatase activity
Mal52_20560	COG0745	RESPONSE REGULATOR receiver
Mal52_20650	COG1216	Glycosyl transferase, family 2
Mal52_20650	COG0438	transferase activity, transferring glycosyl groups
Mal52_20710	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Mal52_20930	COG0367	asparagine synthase
Mal52_20940	COG0438	transferase activity, transferring glycosyl groups
Mal52_20950	COG1505	serine-type exopeptidase activity
Mal52_20970	COG0438	transferase activity, transferring glycosyl groups
Mal52_20980	COG0457	Tetratricopeptide repeat
Mal52_20990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Mal52_21010	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Mal52_21020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Mal52_21100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Mal52_21110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mal52_21140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Mal52_21210	COG2062	phosphohistidine phosphatase, SixA
Mal52_21220	COG0066	3-isopropylmalate dehydratase activity
Mal52_21230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Mal52_21240	COG0575	Belongs to the CDS family
Mal52_21250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Mal52_21260	COG1229	Formylmethanofuran dehydrogenase subunit A
Mal52_21320	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Mal52_21340	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Mal52_21410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Mal52_21430	COG2130	NADP-dependent
Mal52_21460	COG0653	protein targeting
Mal52_21490	COG0247	lactate metabolic process
Mal52_21500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Mal52_21510	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Mal52_21550	COG0673	inositol 2-dehydrogenase activity
Mal52_21600	COG2322	membrane
Mal52_21620	COG1131	(ABC) transporter
Mal52_21650	COG0109	protoheme IX farnesyltransferase activity
Mal52_21670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Mal52_21680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Mal52_21730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Mal52_21740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Mal52_21810	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_21900	COG0443	Heat shock 70 kDa protein
Mal52_21930	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mal52_21950	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Mal52_22070	COG0406	alpha-ribazole phosphatase activity
Mal52_22100	COG0673	inositol 2-dehydrogenase activity
Mal52_22170	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Mal52_22180	COG0438	transferase activity, transferring glycosyl groups
Mal52_22200	COG0275	rRNA processing
Mal52_22230	COG0768	penicillin binding
Mal52_22240	COG0011	TIGRFAM Protein of
Mal52_22250	COG0426	domain, Protein
Mal52_22250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Mal52_22260	COG0277	FAD linked oxidase domain protein
Mal52_22270	COG0277	FAD linked oxidase domain protein
Mal52_22280	COG0659	secondary active sulfate transmembrane transporter activity
Mal52_22290	COG2815	serine threonine protein kinase
Mal52_22290	COG0515	serine threonine protein kinase
Mal52_22320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_22360	COG4191	Histidine kinase
Mal52_22520	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Mal52_22560	COG0463	Glycosyl transferase, family 2
Mal52_22760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Mal52_22770	COG3481	metal-dependent phosphohydrolase, HD sub domain
Mal52_22840	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
Mal52_22850	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Mal52_22910	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Mal52_22950	COG5002	protein histidine kinase activity
Mal52_22970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Mal52_22980	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Mal52_23040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Mal52_23050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Mal52_23060	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Mal52_23070	COG0736	holo-[acyl-carrier-protein] synthase activity
Mal52_23100	COG0180	Tryptophanyl-tRNA synthetase
Mal52_23110	COG0167	dihydroorotate dehydrogenase activity
Mal52_23160	COG0303	'Molybdopterin
Mal52_23170	COG0303	'Molybdopterin
Mal52_23260	COG0473	3-isopropylmalate dehydrogenase activity
Mal52_23340	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Mal52_23350	COG1519	Transferase
Mal52_23360	COG0653	protein targeting
Mal52_23370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Mal52_23390	COG3119	arylsulfatase activity
Mal52_23500	COG0477	Major facilitator Superfamily
Mal52_23520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Mal52_23520	COG0195	Participates in both transcription termination and antitermination
Mal52_23530	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Mal52_23540	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Mal52_23570	COG0217	transcriptional regulatory protein
Mal52_23630	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Mal52_23630	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mal52_23630	COG1013	pyruvate-flavodoxin oxidoreductase activity
Mal52_23630	COG0674	pyruvate-flavodoxin oxidoreductase activity
Mal52_23640	COG0674	pyruvate-flavodoxin oxidoreductase activity
Mal52_23650	COG2040	homocysteine
Mal52_23670	COG1466	dna polymerase III delta subunit
Mal52_23680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Mal52_23770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Mal52_23770	COG0519	Catalyzes the synthesis of GMP from XMP
Mal52_23870	COG1253	flavin adenine dinucleotide binding
Mal52_23880	COG0598	Magnesium transport protein CorA
Mal52_23890	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Mal52_23920	COG0039	L-malate dehydrogenase activity
Mal52_23930	COG0235	Class ii aldolase
Mal52_24000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Mal52_24010	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Mal52_24020	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Mal52_24030	COG4869	propanediol catabolic process
Mal52_24040	COG1349	DNA-binding transcription factor activity
Mal52_24050	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Mal52_24070	COG3118	belongs to the thioredoxin family
Mal52_24110	COG0693	protein deglycase activity
Mal52_24130	COG3385	transposase activity
Mal52_24140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Mal52_24190	COG1136	(ABC) transporter
Mal52_24190	COG0577	efflux transmembrane transporter activity
Mal52_24200	COG1136	(ABC) transporter
Mal52_24270	COG0714	Associated with various cellular activities
Mal52_24280	COG3119	arylsulfatase activity
Mal52_24300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Mal52_24330	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Mal52_24340	COG0673	inositol 2-dehydrogenase activity
Mal52_24360	COG4106	trans-aconitate 2-methyltransferase activity
Mal52_24370	COG0728	peptidoglycan biosynthetic process
Mal52_24450	COG0733	neurotransmitter:sodium symporter activity
Mal52_24510	COG1490	D-aminoacyl-tRNA deacylase activity
Mal52_24530	COG0825	malonyl-CoA metabolic process
Mal52_24580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Mal52_24610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Mal52_24620	COG0363	glucosamine-6-phosphate deaminase activity
Mal52_24630	COG0823	Involved in the tonB-independent uptake of proteins
Mal52_24660	COG1073	alpha beta
Mal52_24670	COG0372	Belongs to the citrate synthase family
Mal52_24690	COG2813	Specifically methylates the guanine in position
Mal52_24770	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_24800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mal52_24830	COG1053	succinate dehydrogenase
Mal52_24850	COG0557	exoribonuclease II activity
Mal52_24860	COG0277	FAD linked oxidase domain protein
Mal52_24890	COG0564	pseudouridine synthase activity
Mal52_24930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Mal52_24990	COG1024	Enoyl-CoA hydratase
Mal52_25080	COG0793	Belongs to the peptidase S41A family
Mal52_25090	COG1131	(ABC) transporter
Mal52_25140	COG0222	ribosome binding
Mal52_25160	COG0148	phosphopyruvate hydratase activity
Mal52_25190	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Mal52_25210	COG2079	MmgE PrpD family protein
Mal52_25240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Mal52_25370	COG0004	ammonium transporteR
Mal52_25380	COG0347	Belongs to the P(II) protein family
Mal52_25490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Mal52_25530	COG1181	Belongs to the D-alanine--D-alanine ligase family
Mal52_25540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Mal52_25550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Mal52_25570	COG2208	phosphoserine phosphatase activity
Mal52_25570	COG2770	Histidine kinase
Mal52_25580	COG3119	arylsulfatase activity
Mal52_25670	COG1127	ABC transporter
Mal52_25680	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Mal52_25700	COG3119	arylsulfatase activity
Mal52_25750	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_25770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mal52_25810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Mal52_25820	COG0459	protein refolding
Mal52_25860	COG0137	argininosuccinate synthase activity
Mal52_25870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Mal52_25970	COG1459	type II secretion system
Mal52_25980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_26070	COG4796	Type ii and iii secretion system protein
Mal52_26130	COG1312	Catalyzes the dehydration of D-mannonate
Mal52_26180	COG2226	methyltransferase
Mal52_26190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Mal52_26200	COG0698	ribose 5-phosphate isomerase
Mal52_26210	COG0509	glycine decarboxylation via glycine cleavage system
Mal52_26220	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Mal52_26230	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Mal52_26240	COG0095	Lipoate-protein ligase
Mal52_26250	COG1716	ATPase activity
Mal52_26290	COG2208	phosphoserine phosphatase activity
Mal52_26290	COG2770	Histidine kinase
Mal52_26380	COG0235	Class ii aldolase
Mal52_26440	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Mal52_26450	COG0126	phosphoglycerate kinase activity
Mal52_26470	COG3320	Male sterility
Mal52_26470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mal52_26480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Mal52_26490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Mal52_26500	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Mal52_26510	COG0237	dephospho-CoA kinase activity
Mal52_26520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Mal52_26520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Mal52_26550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mal52_26570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Mal52_26580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mal52_26590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mal52_26720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Mal52_26730	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Mal52_26740	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Mal52_26770	COG0556	nucleotide-excision repair
Mal52_26820	COG1073	alpha beta
Mal52_26830	COG0384	phenazine biosynthesis protein PhzF
Mal52_26840	COG0384	phenazine biosynthesis protein PhzF
Mal52_26940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Mal52_26940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Mal52_26990	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Mal52_27040	COG1045	serine acetyltransferase
Mal52_27090	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Mal52_27110	COG0386	Belongs to the glutathione peroxidase family
Mal52_27140	COG4864	UPF0365 protein
Mal52_27240	COG4249	Peptidase C14 caspase catalytic subunit p20
Mal52_27350	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Mal52_27440	COG3002	Belongs to the UPF0753 family
Mal52_27450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Mal52_27460	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mal52_27500	COG0604	alcohol dehydrogenase
Mal52_27500	COG3321	synthase
Mal52_27510	COG0702	epimerase
Mal52_27560	COG3795	YCII-related domain
Mal52_27600	COG3795	YCII-related domain
Mal52_27630	COG4941	Belongs to the sigma-70 factor family
Mal52_27690	COG0515	serine threonine protein kinase
Mal52_27690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Mal52_27740	COG2815	serine threonine protein kinase
Mal52_27740	COG0515	serine threonine protein kinase
Mal52_27780	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Mal52_27810	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
Mal52_27930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Mal52_28050	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Mal52_28070	COG1475	DNA binding
Mal52_28200	COG3119	arylsulfatase activity
Mal52_28250	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Mal52_28250	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Mal52_28280	COG0204	Acyl-transferase
Mal52_28280	COG0318	PFAM AMP-dependent synthetase and ligase
Mal52_28320	COG4294	response to UV
Mal52_28390	COG1285	pathogenesis
Mal52_28440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Mal52_28490	COG1606	tRNA processing
Mal52_28550	COG0463	Glycosyl transferase, family 2
Mal52_28600	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Mal52_28620	COG0527	aspartate kinase activity
Mal52_28690	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Mal52_28750	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Mal52_28800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Mal52_28810	COG0321	lipoyl(octanoyl) transferase activity
Mal52_28820	COG1160	GTP binding
Mal52_28830	COG1562	ergosterol biosynthetic process
Mal52_28840	COG1562	ergosterol biosynthetic process
Mal52_28850	COG2815	serine threonine protein kinase
Mal52_28850	COG0515	serine threonine protein kinase
Mal52_28860	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Mal52_28930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mal52_28960	COG0463	Glycosyl transferase, family 2
Mal52_28980	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Mal52_28990	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Mal52_29000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Mal52_29080	COG0135	phosphoribosylanthranilate isomerase activity
Mal52_29100	COG2832	Protein of unknown function (DUF454)
Mal52_29110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Mal52_29150	COG4336	lyase activity
Mal52_29210	COG4191	Histidine kinase
Mal52_29320	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Mal52_29320	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Mal52_29420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Mal52_29470	COG2165	general secretion pathway protein
Mal52_29670	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
Mal52_29710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mal52_29720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mal52_29750	COG0402	S-adenosylhomocysteine deaminase activity
Mal52_29760	COG1187	pseudouridine synthase activity
Mal52_29770	COG0543	2 iron, 2 sulfur cluster binding
Mal52_29820	COG2172	sigma factor antagonist activity
Mal52_29840	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Mal52_29850	COG2217	Heavy metal translocating P-type atpase
Mal52_29880	COG2132	Multicopper oxidase
Mal52_30020	COG1475	DNA binding
Mal52_30190	COG0420	3'-5' exonuclease activity
Mal52_30200	COG4717	serine-type aminopeptidase activity
Mal52_30200	COG4717	serine-type aminopeptidase activity
Mal52_30280	COG3209	COG3209 Rhs family protein
Mal52_30320	COG3209	COG3209 Rhs family protein
Mal52_30350	COG1450	Type ii and iii secretion system protein
Mal52_30360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_30460	COG1459	type II secretion system
Mal52_30620	COG3645	SOS response
Mal52_30790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Mal52_30820	COG1475	DNA binding
Mal52_30970	COG0714	Associated with various cellular activities
Mal52_30990	COG3552	Protein containing von Willebrand factor type A (VWA) domain
Mal52_31000	COG0668	transmembrane transport
Mal52_31010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Mal52_31040	COG1566	PFAM secretion protein HlyD family protein
Mal52_31100	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Mal52_31120	COG0589	response to stress
Mal52_31130	COG0515	serine threonine protein kinase
Mal52_31180	COG1309	transcriptional regulator
Mal52_31230	COG0515	serine threonine protein kinase
Mal52_31230	COG0457	Tetratricopeptide repeat
Mal52_31250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Mal52_31410	COG3541	Predicted nucleotidyltransferase
Mal52_31430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Mal52_31530	COG3119	arylsulfatase activity
Mal52_31550	COG0577	efflux transmembrane transporter activity
Mal52_31550	COG1136	(ABC) transporter
Mal52_31630	COG1131	(ABC) transporter
Mal52_31680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Mal52_31710	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
Mal52_31780	COG2815	serine threonine protein kinase
Mal52_31780	COG0515	serine threonine protein kinase
Mal52_31790	COG1842	Phage shock protein A
Mal52_31870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Mal52_31900	COG2204	response regulator
Mal52_31910	COG4191	Histidine kinase
Mal52_31930	COG1320	monovalent cation:proton antiporter activity
Mal52_31940	COG2212	antiporter activity
Mal52_31950	COG1863	multisubunit Na H antiporter MnhE subunit
Mal52_31960	COG0651	ATP synthesis coupled electron transport
Mal52_31970	COG1006	Multisubunit Na H antiporter MnhC subunit
Mal52_31980	COG2111	Na H antiporter
Mal52_31990	COG2111	Na H antiporter
Mal52_31990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Mal52_32000	COG3189	MarR family transcriptional regulator
Mal52_32050	COG4968	Prepilin-type N-terminal cleavage methylation domain
Mal52_32090	COG0714	Associated with various cellular activities
Mal52_32150	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Mal52_32210	COG0443	Heat shock 70 kDa protein
Mal52_32260	COG2205	protein histidine kinase activity
Mal52_32260	COG5002	protein histidine kinase activity
Mal52_32260	COG0784	Response regulator, receiver
Mal52_32270	COG3437	response regulator, receiver
Mal52_32280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Mal52_32300	COG0702	epimerase
Mal52_32330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Mal52_32340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Mal52_32360	COG1231	oxidoreductase activity
Mal52_32380	COG0123	including yeast histone deacetylase and acetoin utilization protein
Mal52_32390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Mal52_32390	COG0045	succinate-CoA ligase (ADP-forming) activity
Mal52_32390	COG1042	CoA-binding domain protein
Mal52_32420	COG2226	methyltransferase
Mal52_32560	COG3540	Alkaline phosphatase
Mal52_32580	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
Mal52_32590	COG1017	nitric oxide dioxygenase activity
Mal52_32590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Mal52_32600	COG1959	2 iron, 2 sulfur cluster binding
Mal52_32620	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Mal52_32660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mal52_32670	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Mal52_32680	COG2971	BadF BadG BcrA BcrD
Mal52_32770	COG0564	pseudouridine synthase activity
Mal52_32860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Mal52_32900	COG2815	serine threonine protein kinase
Mal52_32900	COG0515	serine threonine protein kinase
Mal52_33000	COG1136	(ABC) transporter
Mal52_33010	COG0577	efflux transmembrane transporter activity
Mal52_33010	COG1136	(ABC) transporter
Mal52_33020	COG0243	molybdopterin cofactor binding
Mal52_33030	COG0437	4 iron, 4 sulfur cluster binding
Mal52_33040	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Mal52_33050	COG2223	nitrite transmembrane transporter activity
Mal52_33190	COG0530	calcium, potassium:sodium antiporter activity
Mal52_33220	COG0443	Heat shock 70 kDa protein
Mal52_33240	COG0515	serine threonine protein kinase
Mal52_33260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Mal52_33280	COG0446	pyridine nucleotide-disulphide oxidoreductase
Mal52_33340	COG2261	transglycosylase associated protein
Mal52_33350	COG0523	cobalamin synthesis protein
Mal52_33360	COG1234	tRNA 3'-trailer cleavage
Mal52_33380	COG2321	neutral zinc metallopeptidase
Mal52_33390	COG0668	transmembrane transport
Mal52_33430	COG0653	protein targeting
Mal52_33730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Mal52_33740	COG1940	carbohydrate kinase activity
Mal52_33790	COG0513	Belongs to the DEAD box helicase family
Mal52_33800	COG3119	arylsulfatase activity
Mal52_33880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Mal52_33890	COG0436	Aminotransferase
Mal52_33910	COG1408	metallophosphoesterase
Mal52_33930	COG0277	FAD linked oxidase domain protein
Mal52_33930	COG0247	lactate metabolic process
Mal52_33940	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Mal52_33960	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Mal52_34000	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Mal52_34010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Mal52_34170	COG0659	secondary active sulfate transmembrane transporter activity
Mal52_34180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Mal52_34220	COG1702	phosphate starvation-inducible protein PhoH
Mal52_34230	COG1480	7TM receptor with intracellular HD hydrolase
Mal52_34240	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Mal52_34280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Mal52_34280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Mal52_34290	COG0114	fumarate hydratase activity
Mal52_34420	COG0859	PFAM glycosyl transferase family 9
Mal52_34420	COG0457	Tetratricopeptide repeat
Mal52_34450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Mal52_34520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Mal52_34550	COG3119	arylsulfatase activity
Mal52_34570	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_34680	COG1482	cell wall glycoprotein biosynthetic process
Mal52_34700	COG2855	membrane
Mal52_34790	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Mal52_34850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mal52_34860	COG0318	PFAM AMP-dependent synthetase and ligase
Mal52_34900	COG0823	Involved in the tonB-independent uptake of proteins
Mal52_34980	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Mal52_35000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Mal52_35010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Mal52_35070	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mal52_35090	COG3119	arylsulfatase activity
Mal52_35130	COG0456	acetyltransferase
Mal52_35140	COG0612	Peptidase, M16
Mal52_35150	COG0612	Peptidase, M16
Mal52_35160	COG3361	conserved protein (COG2071)
Mal52_35170	COG1278	Cold shock
Mal52_35180	COG0434	BtpA family
Mal52_35190	COG0534	Mate efflux family protein
Mal52_35210	COG3104	oligopeptide transport
Mal52_35300	COG1073	alpha beta
Mal52_35440	COG3264	Mechanosensitive ion channel
Mal52_35440	COG1196	nuclear chromosome segregation
Mal52_35510	COG1132	(ABC) transporter
Mal52_35520	COG1283	sodium-dependent phosphate transmembrane transporter activity
Mal52_35560	COG0321	lipoyl(octanoyl) transferase activity
Mal52_35560	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Mal52_35580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Mal52_35590	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Mal52_35610	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Mal52_35650	COG1191	sigma factor activity
Mal52_35670	COG0455	bacterial-type flagellum organization
Mal52_35680	COG1419	protein localization to endoplasmic reticulum
Mal52_35690	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Mal52_35720	COG4589	Belongs to the CDS family
Mal52_35740	COG2267	carboxylic ester hydrolase activity
Mal52_35750	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Mal52_35800	COG0673	inositol 2-dehydrogenase activity
Mal52_35810	COG0617	tRNA 3'-terminal CCA addition
Mal52_35820	COG0205	6-phosphofructokinase activity
Mal52_35830	COG0439	Biotin carboxylase
Mal52_35840	COG0511	ligase activity, forming carbon-carbon bonds
Mal52_35850	COG0006	proline dipeptidase activity
Mal52_35870	COG1136	(ABC) transporter
Mal52_35870	COG0577	efflux transmembrane transporter activity
Mal52_35900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mal52_35920	COG1546	Belongs to the CinA family
Mal52_35920	COG1058	Belongs to the CinA family
Mal52_35950	COG4864	UPF0365 protein
Mal52_36010	COG0811	peptide transport
Mal52_36020	COG0848	biopolymer transport protein
Mal52_36040	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Mal52_36050	COG0515	serine threonine protein kinase
Mal52_36050	COG2815	serine threonine protein kinase
Mal52_36110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Mal52_36150	COG0656	L-ascorbic acid biosynthetic process
Mal52_36180	COG0438	transferase activity, transferring glycosyl groups
Mal52_36240	COG1073	alpha beta
Mal52_36280	COG3153	acetyltransferase
Mal52_36290	COG1136	(ABC) transporter
Mal52_36330	COG4566	intracellular signal transduction
Mal52_36340	COG4191	Histidine kinase
Mal52_36420	COG1136	(ABC) transporter
Mal52_36450	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Mal52_36460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Mal52_36530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Mal52_36590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Mal52_36600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Mal52_36610	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Mal52_36630	COG2385	sporulation resulting in formation of a cellular spore
Mal52_36640	COG0202	RNA polymerase activity
Mal52_36700	COG0045	succinate-CoA ligase (ADP-forming) activity
Mal52_36710	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Mal52_36720	COG0105	UTP biosynthetic process
Mal52_36750	COG1131	(ABC) transporter
Mal52_36810	COG3339	Conserved Protein
Mal52_36880	COG0515	serine threonine protein kinase
Mal52_36880	COG2815	serine threonine protein kinase
Mal52_37160	COG1192	Involved in chromosome partitioning
Mal52_37190	COG5433	transposase activity
Mal52_37330	COG1278	Cold shock
Mal52_37400	COG0673	inositol 2-dehydrogenase activity
Mal52_37420	COG1943	Transposase
Mal52_37480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Mal52_37490	COG3781	membrane
Mal52_37510	COG0515	serine threonine protein kinase
Mal52_37510	COG2815	serine threonine protein kinase
Mal52_37700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Mal52_37730	COG0116	Belongs to the methyltransferase superfamily
Mal52_37740	COG0745	RESPONSE REGULATOR receiver
Mal52_37790	COG3959	Transketolase, thiamine diphosphate binding domain
Mal52_37800	COG3958	Transketolase
Mal52_37820	COG2062	phosphohistidine phosphatase, SixA
Mal52_37860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Mal52_37910	COG0657	acetylesterase activity
Mal52_37920	COG1073	alpha beta
Mal52_37940	COG0673	inositol 2-dehydrogenase activity
Mal52_37990	COG0673	inositol 2-dehydrogenase activity
Mal52_38000	COG4566	intracellular signal transduction
Mal52_38200	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Mal52_38210	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Mal52_38220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Mal52_38230	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Mal52_38240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Mal52_38260	COG1045	serine acetyltransferase
Mal52_38310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Mal52_38330	COG1940	carbohydrate kinase activity
Mal52_38340	COG0481	GTPase activity
Mal52_38370	COG1137	ATPase activity
Mal52_38390	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_38440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Mal52_38450	COG1217	gtp-binding protein TYPA
Mal52_38500	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_38510	COG2022	thiamine diphosphate biosynthetic process
Mal52_38530	COG4112	unkown
Mal52_38580	COG2204	response regulator
Mal52_38590	COG4191	Histidine kinase
Mal52_38600	COG0297	glycogen (starch) synthase activity
Mal52_38680	COG0367	asparagine synthase
Mal52_38700	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Mal52_38780	COG0714	Associated with various cellular activities
Mal52_38870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_38890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Mal52_38900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Mal52_39020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_39110	COG1450	Type ii and iii secretion system protein
Mal52_39150	COG0673	inositol 2-dehydrogenase activity
Mal52_39180	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Mal52_39190	COG1250	3-hydroxyacyl-CoA dehydrogenase
Mal52_39240	COG0859	PFAM glycosyl transferase family 9
Mal52_39290	COG0719	Fe-S assembly protein
Mal52_39300	COG0719	Fe-S assembly protein
Mal52_39320	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mal52_39340	COG1115	amino acid carrier protein
Mal52_39350	COG0589	response to stress
Mal52_39390	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Mal52_39410	COG0071	Belongs to the small heat shock protein (HSP20) family
Mal52_39420	COG0071	Belongs to the small heat shock protein (HSP20) family
Mal52_39460	COG0589	response to stress
Mal52_39500	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Mal52_39600	COG0586	Pfam SNARE associated Golgi protein
Mal52_39620	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Mal52_39640	COG3842	ATPase activity
Mal52_39690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Mal52_39710	COG2985	domain, Protein
Mal52_39710	COG0490	domain, Protein
Mal52_39730	COG1959	2 iron, 2 sulfur cluster binding
Mal52_39740	COG1879	ABC-type sugar transport system periplasmic component
Mal52_39780	COG0113	porphobilinogen synthase activity
Mal52_39820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Mal52_39830	COG0793	Belongs to the peptidase S41A family
Mal52_39840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Mal52_39920	COG3119	arylsulfatase activity
Mal52_39940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mal52_39960	COG1063	alcohol dehydrogenase
Mal52_40020	COG1449	Belongs to the glycosyl hydrolase 57 family
Mal52_40050	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Mal52_40160	COG3253	May function as heme-dependent peroxidase
Mal52_40180	COG1129	ABC transporter
Mal52_40270	COG0745	RESPONSE REGULATOR receiver
Mal52_40280	COG5002	protein histidine kinase activity
Mal52_40300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Mal52_40400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Mal52_40410	COG0037	tRNA processing
Mal52_40430	COG1418	mRNA catabolic process
Mal52_40450	COG0657	acetylesterase activity
Mal52_40560	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_40610	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Mal52_40620	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Mal52_40630	COG3119	arylsulfatase activity
Mal52_40670	COG3118	belongs to the thioredoxin family
Mal52_40680	COG3604	Transcriptional regulator
Mal52_40710	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Mal52_40780	COG0584	glycerophosphoryl diester phosphodiesterase
Mal52_40990	COG0385	Bile acid
Mal52_41000	COG0154	amidase activity
Mal52_41010	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Mal52_41020	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Mal52_41040	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Mal52_41100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Mal52_41130	COG1959	2 iron, 2 sulfur cluster binding
Mal52_41160	COG4191	Histidine kinase
Mal52_41230	COG0481	GTPase activity
Mal52_41270	COG3537	Alpha-1,2-mannosidase
Mal52_41290	COG0745	RESPONSE REGULATOR receiver
Mal52_41300	COG2205	protein histidine kinase activity
Mal52_41340	COG0072	phenylalanine-tRNA ligase activity
Mal52_41390	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_41430	COG0590	tRNA wobble adenosine to inosine editing
Mal52_41540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Mal52_41640	COG1162	GTPase activity
Mal52_41670	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_41680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_41710	COG1058	Belongs to the CinA family
Mal52_41710	COG1546	Belongs to the CinA family
Mal52_41740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Mal52_41760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Mal52_41760	COG0574	Belongs to the PEP-utilizing enzyme family
Mal52_41770	COG0784	Response regulator, receiver
Mal52_41780	COG3119	arylsulfatase activity
Mal52_41870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Mal52_41900	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Mal52_41910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Mal52_41920	COG2897	thiosulfate sulfurtransferase activity
Mal52_41930	COG2815	serine threonine protein kinase
Mal52_41930	COG0515	serine threonine protein kinase
Mal52_42000	COG3394	polysaccharide catabolic process
Mal52_42130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Mal52_42150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Mal52_42210	COG5564	TIM-barrel signal transduction protein
Mal52_42260	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_42310	COG3437	response regulator, receiver
Mal52_42330	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_42410	COG1082	Xylose isomerase domain protein TIM barrel
Mal52_42460	COG0129	dihydroxy-acid dehydratase activity
Mal52_42470	COG2204	response regulator
Mal52_42500	COG0442	prolyl-tRNA aminoacylation
Mal52_42520	COG0432	Pfam Uncharacterised protein family UPF0047
Mal52_42540	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Mal52_42540	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Mal52_42570	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Mal52_42570	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Mal52_42580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Mal52_42590	COG0617	tRNA 3'-terminal CCA addition
Mal52_42610	COG2719	SpoVR family
Mal52_42630	COG2718	Belongs to the UPF0229 family
Mal52_42640	COG2766	serine protein kinase
Mal52_42660	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Mal52_42720	COG2201	protein-glutamate methylesterase activity
Mal52_42740	COG2198	Histidine kinase
Mal52_42740	COG0784	Response regulator, receiver
Mal52_42740	COG0643	Histidine kinase
Mal52_42750	COG0612	Peptidase, M16
Mal52_42800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Mal52_42800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Mal52_42930	COG2815	serine threonine protein kinase
Mal52_42930	COG0515	serine threonine protein kinase
Mal52_42970	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Mal52_42990	COG2183	response to ionizing radiation
Mal52_43020	COG4191	Histidine kinase
Mal52_43220	COG0134	indole-3-glycerol-phosphate synthase activity
Mal52_43340	COG0714	Associated with various cellular activities
Mal52_43380	COG1131	(ABC) transporter
Mal52_43420	COG1131	(ABC) transporter
Mal52_43500	COG1918	ferrous iron import across plasma membrane
Mal52_43500	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Mal52_43520	COG3383	formate dehydrogenase (NAD+) activity
Mal52_43580	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Mal52_43600	COG0179	Fumarylacetoacetate (FAA) hydrolase
Mal52_43630	COG0515	serine threonine protein kinase
Mal52_43660	COG2197	response regulator
Mal52_43710	COG1082	Xylose isomerase domain protein TIM barrel
Mal52_43790	COG0154	amidase activity
Mal52_43900	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Mal52_43910	COG0839	Belongs to the complex I subunit 6 family
Mal52_43920	COG0713	ATP synthesis coupled electron transport
Mal52_43930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Mal52_43950	COG1007	ATP synthesis coupled electron transport
Mal52_43970	COG0084	hydrolase, TatD family'
Mal52_43990	COG0495	leucyl-tRNA aminoacylation
Mal52_44010	COG0569	domain protein
Mal52_44020	COG1454	alcohol dehydrogenase
Mal52_44090	COG2815	serine threonine protein kinase
Mal52_44090	COG0515	serine threonine protein kinase
Mal52_44120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Mal52_44130	COG0109	protoheme IX farnesyltransferase activity
Mal52_44170	COG3119	arylsulfatase activity
Mal52_44170	COG3408	Glycogen debranching enzyme
Mal52_44310	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Mal52_44320	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Mal52_44370	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Mal52_44380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Mal52_44390	COG2852	Protein conserved in bacteria
Mal52_44400	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_44410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mal52_44420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Mal52_44630	COG0673	inositol 2-dehydrogenase activity
Mal52_44710	COG2721	sulfolactate sulfo-lyase activity
Mal52_44720	COG0673	inositol 2-dehydrogenase activity
Mal52_44960	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Mal52_44970	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Mal52_44980	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Mal52_44990	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Mal52_45030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Mal52_45090	COG0577	efflux transmembrane transporter activity
Mal52_45100	COG1136	(ABC) transporter
Mal52_45180	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_45320	COG3273	potassium ion transport
Mal52_45320	COG0471	metal ion transport
Mal52_45370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Mal52_45390	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Mal52_45400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Mal52_45430	COG5002	protein histidine kinase activity
Mal52_45440	COG0745	RESPONSE REGULATOR receiver
Mal52_45470	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Mal52_45480	COG0233	cytoplasmic translational termination
Mal52_45490	COG0528	UMP kinase activity
Mal52_45580	COG0588	phosphoglycerate mutase activity
Mal52_45620	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Mal52_45630	COG3119	arylsulfatase activity
Mal52_45660	COG2373	Large extracellular alpha-helical protein
Mal52_45670	COG1757	Na H antiporter
Mal52_45680	COG3852	Histidine kinase
Mal52_45700	COG0445	tRNA wobble uridine modification
Mal52_45710	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Mal52_45720	COG2962	Rard protein
Mal52_45730	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Mal52_45740	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_45810	COG1136	(ABC) transporter
Mal52_45820	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mal52_45830	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Mal52_45970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Mal52_46000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mal52_46040	COG2192	nodulation
Mal52_46060	COG1131	(ABC) transporter
Mal52_46150	COG0405	Gamma-glutamyltransferase
Mal52_46160	COG1691	(AIR) carboxylase
Mal52_46220	COG0542	response to heat
Mal52_46230	COG0504	CTP synthase activity
Mal52_46240	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Mal52_46250	COG0459	protein refolding
Mal52_46260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Mal52_46270	COG0459	protein refolding
Mal52_46280	COG0484	heat shock protein binding
Mal52_46290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Mal52_46340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Mal52_46350	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Mal52_46360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Mal52_46370	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Mal52_46380	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Mal52_46390	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Mal52_46400	COG2084	Dehydrogenase
Mal52_46510	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Mal52_46530	COG0019	diaminopimelate decarboxylase activity
Mal52_46570	COG2204	response regulator
Mal52_46780	COG1528	Iron-storage protein
Mal52_47080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Mal52_47090	COG0539	negative regulation of cytoplasmic translation
Mal52_47090	COG2183	response to ionizing radiation
Mal52_47120	COG1022	Amp-dependent synthetase and ligase
Mal52_47130	COG0183	Belongs to the thiolase family
Mal52_47150	COG0179	Fumarylacetoacetate (FAA) hydrolase
Mal52_47200	COG0529	Catalyzes the synthesis of activated sulfate
Mal52_47240	COG0745	RESPONSE REGULATOR receiver
Mal52_47250	COG2201	protein-glutamate methylesterase activity
Mal52_47260	COG2205	protein histidine kinase activity
Mal52_47340	COG4191	Histidine kinase
Mal52_47350	COG0784	Response regulator, receiver
Mal52_47360	COG4191	Histidine kinase
Mal52_47370	COG4566	intracellular signal transduction
Mal52_47380	COG3437	response regulator, receiver
Mal52_47480	COG1131	(ABC) transporter
Mal52_47500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Mal52_47500	COG1754	DNA topoisomerase type I activity
Mal52_47520	COG2226	methyltransferase
Mal52_47540	COG1136	(ABC) transporter
Mal52_47550	COG4591	ABC-type transport system involved in lipoprotein release permease component
Mal52_47570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Mal52_47580	COG0124	histidyl-tRNA synthetase
Mal52_47620	COG0564	pseudouridine synthase activity
Mal52_47660	COG0805	protein transport
Mal52_47680	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Mal52_47690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Mal52_47710	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Mal52_47720	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Mal52_47720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Mal52_47790	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Mal52_47890	COG2001	Belongs to the MraZ family
Mal52_47900	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Mal52_47930	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Mal52_47950	COG4651	solute:proton antiporter activity
Mal52_47950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Mal52_47980	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Mal52_48040	COG0398	Pfam SNARE associated Golgi protein
Mal52_48060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Mal52_48070	COG1758	RNA polymerase activity
Mal52_48080	COG0194	GDP metabolic process
Mal52_48090	COG1561	YicC-like family, N-terminal region
Mal52_48110	COG0149	triose-phosphate isomerase activity
Mal52_48130	COG0077	Prephenate dehydratase
Mal52_48130	COG1605	Chorismate mutase
Mal52_48150	COG0443	Heat shock 70 kDa protein
Mal52_48160	COG1012	belongs to the aldehyde dehydrogenase family
Mal52_48180	COG0628	permease
Mal52_48200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Mal52_48270	COG2234	aminopeptidase activity
Mal52_48320	COG0632	four-way junction helicase activity
Mal52_48330	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Mal52_48330	COG0662	Cupin 2, conserved barrel domain protein
Mal52_48350	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Mal52_48350	COG0517	IMP dehydrogenase activity
Mal52_48380	COG1164	Oligoendopeptidase f
Mal52_48450	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Mal52_48460	COG0215	cysteine-tRNA ligase activity
Mal52_48470	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Mal52_48490	COG0174	glutamine synthetase
Mal52_48530	COG1725	Transcriptional regulator
Mal52_48540	COG1131	(ABC) transporter
Mal52_48570	COG0673	inositol 2-dehydrogenase activity
Mal52_48600	COG2255	four-way junction helicase activity
Mal52_48610	COG0443	Heat shock 70 kDa protein
Mal52_48620	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Mal52_48640	COG2815	serine threonine protein kinase
Mal52_48640	COG0515	serine threonine protein kinase
Mal52_48700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mal52_48730	COG0154	amidase activity
Mal52_48870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Mal52_48880	COG5002	protein histidine kinase activity
Mal52_48920	COG0671	phosphoesterase, PA-phosphatase related
Mal52_48950	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Mal52_48980	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Mal52_48990	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Mal52_49020	COG4109	DRTGG domain
Mal52_49030	COG2423	ornithine cyclodeaminase activity
Mal52_49040	COG0505	Belongs to the CarA family
Mal52_49050	COG0640	Transcriptional regulator
Mal52_49080	COG0714	Associated with various cellular activities
Mal52_49150	COG2258	MOSC domain
Mal52_49200	COG0509	glycine decarboxylation via glycine cleavage system
Mal52_49230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Mal52_49250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Mal52_49260	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Mal52_49290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Mal52_49300	COG0424	maF-like protein
Mal52_49310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Mal52_49330	COG1690	Belongs to the RtcB family
Mal52_49360	COG4232	protein-disulfide reductase activity
Mal52_49390	COG0352	thiamine-phosphate diphosphorylase activity
Mal52_49410	COG0542	response to heat
Mal52_49450	COG0515	serine threonine protein kinase
Mal52_49450	COG2815	serine threonine protein kinase
Mal52_49460	COG2755	lipolytic protein G-D-S-L family
Mal52_49460	COG0657	acetylesterase activity
Mal52_49480	COG1752	Esterase of the alpha-beta hydrolase superfamily
Mal52_49500	COG1960	acyl-CoA dehydrogenase activity
Mal52_49510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Mal52_49520	COG0545	Peptidyl-prolyl cis-trans isomerase
Mal52_49550	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_49580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_49590	COG1459	type II secretion system
Mal52_49700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Mal52_49710	COG0667	Aldo Keto reductase
Mal52_49750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Mal52_49750	COG1587	Uroporphyrinogen-III synthase
Mal52_49770	COG0268	Binds directly to 16S ribosomal RNA
Mal52_49800	COG3642	lipopolysaccharide core region biosynthetic process
Mal52_49840	COG1078	dGTPase activity
Mal52_49850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Mal52_49950	COG4974	Belongs to the 'phage' integrase family
Mal52_50080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Mal52_50120	COG0589	response to stress
Mal52_50190	COG0488	(ABC) transporter
Mal52_50200	COG1012	belongs to the aldehyde dehydrogenase family
Mal52_50230	COG1404	Belongs to the peptidase S8 family
Mal52_50300	COG0673	inositol 2-dehydrogenase activity
Mal52_50330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Mal52_50400	COG2010	Cytochrome c
Mal52_50410	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Mal52_50420	COG1074	ATP-dependent DNA helicase activity
Mal52_50430	COG1122	ATPase activity
Mal52_50490	COG0673	inositol 2-dehydrogenase activity
Mal52_50510	COG2208	phosphoserine phosphatase activity
Mal52_50540	COG1381	Involved in DNA repair and RecF pathway recombination
Mal52_50590	COG3119	arylsulfatase activity
Mal52_50600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Mal52_50650	COG0698	ribose 5-phosphate isomerase
Mal52_50690	COG1525	nuclease
Mal52_50750	COG0571	ribonuclease III activity
Mal52_50830	COG0673	inositol 2-dehydrogenase activity
Mal52_50840	COG0589	response to stress
Mal52_50890	COG0596	Alpha beta hydrolase
Mal52_51000	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Mal52_51030	COG1070	Carbohydrate kinase
Mal52_51050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Mal52_51080	COG1842	Phage shock protein A
Mal52_51090	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
Mal52_51110	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Mal52_51330	COG1595	DNA-templated transcription, initiation
Mal52_51420	COG2835	tetraacyldisaccharide 4'-kinase activity
Mal52_51440	COG0596	Alpha beta hydrolase
Mal52_51500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Mal52_51520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Mal52_51540	COG0584	glycerophosphoryl diester phosphodiesterase
Mal52_51600	COG0802	atpase or kinase
Mal52_51610	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Mal52_51620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_51650	COG0471	metal ion transport
Mal52_51660	COG0589	response to stress
Mal52_51670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Mal52_51700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Mal52_51720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Mal52_51790	COG0305	Participates in initiation and elongation during chromosome replication
Mal52_51800	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Mal52_51810	COG0359	binds to the 23S rRNA
Mal52_51820	COG0629	single-stranded DNA binding
Mal52_51830	COG0360	Binds together with S18 to 16S ribosomal RNA
Mal52_51840	COG0193	aminoacyl-tRNA hydrolase activity
Mal52_51850	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Mal52_52010	COG1129	ABC transporter
Mal52_52070	COG1013	pyruvate-flavodoxin oxidoreductase activity
Mal52_52080	COG0674	pyruvate-flavodoxin oxidoreductase activity
Mal52_52080	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Mal52_52110	COG2815	serine threonine protein kinase
Mal52_52110	COG0515	serine threonine protein kinase
Mal52_52120	COG0540	Belongs to the ATCase OTCase family
Mal52_52130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Mal52_52160	COG4968	Prepilin-type N-terminal cleavage methylation domain
Mal52_52210	COG0515	serine threonine protein kinase
Mal52_52210	COG2815	serine threonine protein kinase
Mal52_52250	COG0606	chelatase, subunit chli
Mal52_52280	COG2815	serine threonine protein kinase
Mal52_52280	COG0515	serine threonine protein kinase
Mal52_52290	COG0628	permease
Mal52_52300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Mal52_52310	COG0601	transmembrane transport
Mal52_52320	COG4166	transmembrane transport
Mal52_52350	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_52360	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Mal52_52420	COG0745	RESPONSE REGULATOR receiver
Mal52_52520	COG3963	phosphatidate phosphatase activity
Mal52_52550	COG0745	RESPONSE REGULATOR receiver
Mal52_52560	COG0006	proline dipeptidase activity
Mal52_52590	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Mal52_52620	COG0515	serine threonine protein kinase
Mal52_52620	COG2815	serine threonine protein kinase
Mal52_52630	COG0028	Belongs to the TPP enzyme family
Mal52_52670	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Mal52_52680	COG0488	(ABC) transporter
Mal52_52690	COG0405	Gamma-glutamyltransferase
Mal52_52770	COG0657	acetylesterase activity
Mal52_52770	COG2755	lipolytic protein G-D-S-L family
Mal52_52780	COG0577	efflux transmembrane transporter activity
Mal52_52780	COG1136	(ABC) transporter
Mal52_52790	COG1136	(ABC) transporter
Mal52_52790	COG0577	efflux transmembrane transporter activity
Mal52_52850	COG0318	PFAM AMP-dependent synthetase and ligase
Mal52_52920	COG1902	pentaerythritol trinitrate reductase activity
Mal52_52930	COG0318	PFAM AMP-dependent synthetase and ligase
Mal52_52940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Mal52_52990	COG4145	pantothenate transmembrane transporter activity
Mal52_53010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Mal52_53080	COG3119	arylsulfatase activity
Mal52_53090	COG0423	glycine-tRNA ligase activity
Mal52_53150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_53160	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Mal52_53180	COG3616	Alanine racemase, N-terminal domain
Mal52_53200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mal52_53210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mal52_53220	COG2995	paraquat-inducible protein a
Mal52_53230	COG3008	intermembrane lipid transfer
Mal52_53240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Mal52_53290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Mal52_53330	COG2815	serine threonine protein kinase
Mal52_53330	COG0515	serine threonine protein kinase
Mal52_53360	COG0483	inositol monophosphate 1-phosphatase activity
Mal52_53410	COG1968	undecaprenyl-diphosphatase activity
Mal52_53470	COG0745	RESPONSE REGULATOR receiver
Mal52_53500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Mal52_53530	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Mal52_53540	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Mal52_53640	COG1475	DNA binding
Mal52_53700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Mal52_53810	COG0210	DNA helicase
Mal52_53820	COG1205	dead DEAH box helicase
Mal52_53820	COG1111	helicase
Mal52_53870	COG1309	transcriptional regulator
Mal52_53890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Mal52_53910	COG1752	Esterase of the alpha-beta hydrolase superfamily
Mal52_53980	COG1082	Xylose isomerase domain protein TIM barrel
Mal52_54030	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Mal52_54050	COG0203	ribosomal protein L17
Mal52_54060	COG0202	RNA polymerase activity
Mal52_54070	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Mal52_54080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Mal52_54090	COG0024	Methionine aminopeptidase
Mal52_54100	COG0201	protein transport
Mal52_54110	COG0200	Binds to the 23S rRNA
Mal52_54120	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Mal52_54130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Mal52_54140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Mal52_54150	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Mal52_54160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Mal52_54170	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Mal52_54180	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Mal52_54190	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Mal52_54210	COG0255	Belongs to the universal ribosomal protein uL29 family
Mal52_54220	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Mal52_54230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Mal52_54240	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Mal52_54250	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Mal52_54260	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Mal52_54270	COG0089	rRNA binding
Mal52_54280	COG0088	Forms part of the polypeptide exit tunnel
Mal52_54290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Mal52_54300	COG0051	transcription antitermination factor activity, RNA binding
Mal52_54310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Mal52_54320	COG0049	tRNA binding
Mal52_54340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Mal52_54350	COG0085	RNA polymerase activity
Mal52_54370	COG0222	ribosome binding
Mal52_54380	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Mal52_54390	COG0081	regulation of translation
Mal52_54400	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Mal52_54440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Mal52_54450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Mal52_54560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mal52_54580	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Mal52_54610	COG0372	Belongs to the citrate synthase family
Mal52_54650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Mal52_54660	COG0772	Belongs to the SEDS family
Mal52_54670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Mal52_54680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Mal52_54690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Mal52_54710	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Mal52_54720	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Mal52_54730	COG0706	membrane insertase activity
Mal52_54730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_54750	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Mal52_54760	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Mal52_54780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Mal52_54800	COG0714	Associated with various cellular activities
Mal52_54820	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Mal52_54850	COG3119	arylsulfatase activity
Mal52_54870	COG2409	Drug exporters of the RND superfamily
Mal52_54880	COG5285	phytanoyl-CoA dioxygenase
Mal52_54910	COG0577	efflux transmembrane transporter activity
Mal52_54960	COG5002	protein histidine kinase activity
Mal52_54960	COG0784	Response regulator, receiver
Mal52_54960	COG2205	protein histidine kinase activity
Mal52_55000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Mal52_55010	COG2878	Part of a membrane complex involved in electron transport
Mal52_55100	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Mal52_55130	COG0339	signal peptide processing
Mal52_55140	COG3458	cephalosporin-C deacetylase activity
Mal52_55150	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Mal52_55170	COG0726	polysaccharide deacetylase
Mal52_55180	COG1473	amidohydrolase
Mal52_55190	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Mal52_55200	COG0322	excinuclease ABC activity
Mal52_55210	COG1250	3-hydroxyacyl-CoA dehydrogenase
Mal52_55210	COG1024	Enoyl-CoA hydratase
Mal52_55240	COG0300	oxidoreductase activity
Mal52_55250	COG0318	PFAM AMP-dependent synthetase and ligase
Mal52_55260	COG1796	DNA polymerase
Mal52_55260	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Mal52_55290	COG0415	Belongs to the DNA photolyase family
Mal52_55360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Mal52_55410	COG2304	oxidoreductase activity
Mal52_55420	COG0018	arginyl-trna synthetase
Mal52_55430	COG0799	negative regulation of ribosome biogenesis
Mal52_55440	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Mal52_55470	COG1131	(ABC) transporter
Mal52_55520	COG0686	Belongs to the AlaDH PNT family
Mal52_55600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Mal52_55650	COG1024	Enoyl-CoA hydratase
Mal52_55690	COG3119	arylsulfatase activity
Mal52_55900	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Mal52_55910	COG2205	protein histidine kinase activity
Mal52_55920	COG0602	queuosine metabolic process
Mal52_55930	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Mal52_55960	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Mal52_56000	COG1131	(ABC) transporter
Mal52_56050	COG1663	tetraacyldisaccharide 4'-kinase activity
Mal52_56080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Mal52_56110	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_56120	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Mal52_56210	COG1475	DNA binding
Mal52_56250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mal52_56260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Mal52_56280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Mal52_56290	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_56300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mal52_56310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Mal52_56320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mal52_56370	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Mal52_56380	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Mal52_56470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Mal52_56500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Mal52_56510	COG0525	valine-tRNA ligase activity
Mal52_56530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Mal52_56540	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Mal52_56580	COG2045	Belongs to the ComB family
Mal52_56630	COG0242	peptide deformylase activity
Mal52_56640	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Mal52_56690	COG2204	response regulator
Mal52_56730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Mal52_56750	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Mal52_56790	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Mal52_56790	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Mal52_56810	COG0297	glycogen (starch) synthase activity
Mal52_56830	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Mal52_56850	COG1363	Peptidase, m42
Mal52_56910	COG0534	Mate efflux family protein
Mal52_56930	COG2274	protein secretion by the type I secretion system
Mal52_56940	COG0673	inositol 2-dehydrogenase activity
Mal52_56960	COG4864	UPF0365 protein
Mal52_57020	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Mal52_57040	COG0456	acetyltransferase
Mal52_57070	COG3119	arylsulfatase activity
Mal52_57080	COG0673	inositol 2-dehydrogenase activity
Mal52_57100	COG1216	Glycosyl transferase, family 2
Mal52_57170	COG1012	belongs to the aldehyde dehydrogenase family
Mal52_57190	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Mal52_57220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Mal52_57250	COG0848	biopolymer transport protein
Mal52_57260	COG0811	peptide transport
Mal52_57270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Mal52_57270	COG3153	acetyltransferase
Mal52_57330	COG1069	ribulokinase activity
Mal52_57370	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Mal52_57380	COG3119	arylsulfatase activity
Mal52_57430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Mal52_57440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mal52_57450	COG1566	PFAM secretion protein HlyD family protein
Mal52_57470	COG0653	protein targeting
Mal52_57480	COG0450	alkyl hydroperoxide reductase
Mal52_57520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Mal52_57530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Mal52_57560	COG3706	GGDEF domain
Mal52_57580	COG0693	protein deglycase activity
Mal52_57590	COG2363	Small membrane protein
Mal52_57610	COG0076	glutamate decarboxylase activity
Mal52_57720	COG5002	protein histidine kinase activity
Mal52_57730	COG1185	polyribonucleotide nucleotidyltransferase activity
Mal52_57740	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Mal52_57750	COG5002	protein histidine kinase activity
Mal52_57800	COG0076	glutamate decarboxylase activity
Mal52_57810	COG3548	integral membrane protein
Mal52_57870	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Mal52_57890	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Mal52_57920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Mal52_57940	COG1845	cytochrome c oxidase, subunit III
Mal52_58010	COG0069	glutamate synthase activity
Mal52_58030	COG0281	malic enzyme
Mal52_58040	COG3961	Belongs to the TPP enzyme family
Mal52_58050	COG1252	NADH dehydrogenase
Mal52_58110	COG2304	oxidoreductase activity
Mal52_58150	COG0714	Associated with various cellular activities
Mal52_58160	COG2204	response regulator
Mal52_58190	COG3118	belongs to the thioredoxin family
Mal52_58220	COG0515	serine threonine protein kinase
Mal52_58220	COG2815	serine threonine protein kinase
Mal52_58240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Mal52_58250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Mal52_58260	COG0730	response to heat
Mal52_58410	COG0798	PFAM Bile acid sodium symporter
Mal52_58420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Mal52_58430	COG0346	lactoylglutathione lyase activity
Mal52_58500	COG4864	UPF0365 protein
Mal52_58510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Mal52_58550	COG1917	Cupin 2, conserved barrel domain protein
Mal52_58560	COG5285	phytanoyl-CoA dioxygenase
Mal52_58580	COG0006	proline dipeptidase activity
Mal52_58600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Mal52_58610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mal52_58620	COG3005	denitrification pathway
Mal52_58630	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Mal52_58660	COG2267	carboxylic ester hydrolase activity
Mal52_58730	COG0515	serine threonine protein kinase
Mal52_58730	COG2815	serine threonine protein kinase
Mal52_58770	COG0786	glutamate:sodium symporter activity
Mal52_58790	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Mal52_58800	COG1523	belongs to the glycosyl hydrolase 13 family
Mal52_58810	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Mal52_58820	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Mal52_58860	COG1269	ATP hydrolysis coupled proton transport
Mal52_58940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mal52_59040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Mal52_59160	COG0017	Asparaginyl-tRNA synthetase
Mal52_59210	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Mal52_59220	COG2088	sporulation resulting in formation of a cellular spore
Mal52_59260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Mal52_59290	COG0316	Belongs to the HesB IscA family
Mal52_59300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Mal52_59310	COG4191	Histidine kinase
Mal52_59320	COG4566	intracellular signal transduction
Mal52_59330	COG0436	Aminotransferase
Mal52_59340	COG0133	tryptophan synthase activity
Mal52_59390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mal52_59440	COG0673	inositol 2-dehydrogenase activity
Mal52_59460	COG0515	serine threonine protein kinase
Mal52_59460	COG2815	serine threonine protein kinase
Mal52_59470	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Mal52_59490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Mal52_59550	COG2017	converts alpha-aldose to the beta-anomer
Mal52_59560	COG1678	Uncharacterized ACR, COG1678
Mal52_59590	COG0714	Associated with various cellular activities
Mal52_59640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Mal52_59650	COG2172	sigma factor antagonist activity
Mal52_59690	COG2815	serine threonine protein kinase
Mal52_59690	COG0515	serine threonine protein kinase
Mal52_59740	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_59770	COG1741	Belongs to the pirin family
Mal52_59800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Mal52_59810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_59840	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Mal52_59920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_60040	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Mal52_60100	COG4977	sequence-specific DNA binding
Mal52_60100	COG1917	Cupin 2, conserved barrel domain protein
Mal52_60190	COG0640	Transcriptional regulator
Mal52_60320	COG0512	Glutamine amidotransferase of anthranilate synthase
Mal52_60340	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Mal52_60350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Mal52_60470	COG2186	Transcriptional regulator
Mal52_60710	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_60720	COG4191	Histidine kinase
Mal52_60720	COG2205	protein histidine kinase activity
Mal52_60720	COG0745	RESPONSE REGULATOR receiver
Mal52_60740	COG2046	Belongs to the sulfate adenylyltransferase family
Mal52_60780	COG0811	peptide transport
Mal52_60790	COG0848	biopolymer transport protein
Mal52_60870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Mal52_60880	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Mal52_60910	COG0300	oxidoreductase activity
Mal52_60920	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Mal52_60930	COG1607	acyl-coa hydrolase
Mal52_60960	COG0024	Methionine aminopeptidase
Mal52_61060	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Mal52_61080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mal52_61090	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mal52_61140	COG1966	Carbon starvation protein
Mal52_61160	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Mal52_61250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Mal52_61260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Mal52_61300	COG0545	Peptidyl-prolyl cis-trans isomerase
Mal52_61380	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Mal52_61710	COG3591	Belongs to the peptidase S1B family
Mal52_61710	COG1864	DNA RNA non-specific endonuclease
Mal52_61740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Mal52_61800	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Mal52_61810	COG0012	GTP binding
Mal52_61850	COG0673	inositol 2-dehydrogenase activity
Mal52_61860	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Mal52_61870	COG1940	carbohydrate kinase activity
Mal52_61900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mal52_61950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Mal52_61960	COG1082	Xylose isomerase domain protein TIM barrel
Mal52_62050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Mal52_62060	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Mal52_62070	COG0563	adenylate kinase activity
Mal52_62080	COG0758	DNA mediated transformation
Mal52_62080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Mal52_62090	COG3385	transposase activity
Mal52_62120	COG0772	Belongs to the SEDS family
Mal52_62130	COG3118	belongs to the thioredoxin family
Mal52_62170	COG0052	Belongs to the universal ribosomal protein uS2 family
Mal52_62180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Mal52_62250	COG1104	cysteine desulfurase activity