locus-tag	class	description
SynA1562_00001	COG0592	DNA-directed DNA polymerase activity
SynA1562_00003	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynA1562_00005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynA1562_00007	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynA1562_00010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynA1562_00011	COG0552	protein localization to endoplasmic reticulum
SynA1562_00012	COG2208	phosphoserine phosphatase activity
SynA1562_00013	COG0165	Argininosuccinate lyase
SynA1562_00014	COG0724	RNA recognition motif
SynA1562_00015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynA1562_00017	COG2081	HI0933 family
SynA1562_00018	COG1459	type II secretion system
SynA1562_00020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynA1562_00021	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynA1562_00022	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynA1562_00023	COG0484	heat shock protein binding
SynA1562_00025	COG1162	GTPase activity
SynA1562_00026	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynA1562_00027	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynA1562_00028	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynA1562_00030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA1562_00031	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynA1562_00032	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1562_00033	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynA1562_00034	COG0511	ligase activity, forming carbon-carbon bonds
SynA1562_00035	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynA1562_00051	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynA1562_00052	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynA1562_00052	COG0519	Catalyzes the synthesis of GMP from XMP
SynA1562_00057	COG0768	penicillin binding
SynA1562_00058	COG0438	transferase activity, transferring glycosyl groups
SynA1562_00059	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA1562_00061	COG2022	thiamine diphosphate biosynthetic process
SynA1562_00064	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynA1562_00065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynA1562_00066	COG2385	sporulation resulting in formation of a cellular spore
SynA1562_00067	COG1215	transferase activity, transferring glycosyl groups
SynA1562_00068	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynA1562_00070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynA1562_00071	COG0740	serine-type endopeptidase activity
SynA1562_00072	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynA1562_00073	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynA1562_00074	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynA1562_00075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynA1562_00080	COG2082	Precorrin-8x methylmutase
SynA1562_00081	COG0037	tRNA processing
SynA1562_00084	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynA1562_00085	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynA1562_00087	COG0556	nucleotide-excision repair
SynA1562_00089	COG0653	protein targeting
SynA1562_00090	COG1045	serine acetyltransferase
SynA1562_00091	COG1725	Transcriptional regulator
SynA1562_00093	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynA1562_00094	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynA1562_00095	COG0187	DNA topoisomerase II activity
SynA1562_00095	COG1372	Participates in initiation and elongation during chromosome replication
SynA1562_00097	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynA1562_00098	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynA1562_00099	COG0386	Belongs to the glutathione peroxidase family
SynA1562_00100	COG2239	Acts as a magnesium transporter
SynA1562_00101	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1562_00102	COG0596	Alpha beta hydrolase
SynA1562_00103	COG1194	a g-specific adenine glycosylase
SynA1562_00105	COG0802	atpase or kinase
SynA1562_00106	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynA1562_00107	COG0586	Pfam SNARE associated Golgi protein
SynA1562_00108	COG0629	single-stranded DNA binding
SynA1562_00110	COG1792	Involved in formation and maintenance of cell shape
SynA1562_00114	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynA1562_00118	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynA1562_00121	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynA1562_00122	COG2255	four-way junction helicase activity
SynA1562_00124	COG1473	amidohydrolase
SynA1562_00127	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynA1562_00128	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynA1562_00129	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynA1562_00130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynA1562_00131	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1562_00132	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynA1562_00144	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynA1562_00145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynA1562_00146	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynA1562_00147	COG0662	Cupin 2, conserved barrel domain protein
SynA1562_00147	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynA1562_00154	COG1216	Glycosyl transferase, family 2
SynA1562_00156	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA1562_00157	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynA1562_00158	COG0662	Cupin 2, conserved barrel domain protein
SynA1562_00158	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynA1562_00159	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynA1562_00161	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1562_00162	COG0571	ribonuclease III activity
SynA1562_00166	COG0058	SHG alpha-glucan phosphorylase activity
SynA1562_00167	COG0475	glutathione-regulated potassium exporter activity
SynA1562_00171	COG0277	FAD linked oxidase domain protein
SynA1562_00173	COG0247	lactate metabolic process
SynA1562_00174	COG0538	isocitrate dehydrogenase activity
SynA1562_00177	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SynA1562_00179	COG5398	heme oxygenase
SynA1562_00181	COG1132	(ABC) transporter
SynA1562_00182	COG0438	transferase activity, transferring glycosyl groups
SynA1562_00185	COG0438	transferase activity, transferring glycosyl groups
SynA1562_00186	COG0438	transferase activity, transferring glycosyl groups
SynA1562_00187	COG0438	transferase activity, transferring glycosyl groups
SynA1562_00190	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynA1562_00197	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynA1562_00198	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynA1562_00199	COG0517	IMP dehydrogenase activity
SynA1562_00199	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SynA1562_00200	COG0617	tRNA 3'-terminal CCA addition
SynA1562_00201	COG0709	Synthesizes selenophosphate from selenide and ATP
SynA1562_00202	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA1562_00203	COG0124	histidyl-tRNA synthetase
SynA1562_00204	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA1562_00205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynA1562_00206	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynA1562_00219	COG4447	cellulose binding
SynA1562_00220	COG1773	rubredoxin
SynA1562_00221	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1562_00222	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1562_00223	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1562_00224	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynA1562_00225	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SynA1562_00227	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1562_00227	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1562_00229	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SynA1562_00230	COG0494	nUDIX hydrolase
SynA1562_00231	COG0415	Belongs to the DNA photolyase family
SynA1562_00232	COG1459	type II secretion system
SynA1562_00238	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynA1562_00239	COG0131	Imidazoleglycerol-phosphate dehydratase
SynA1562_00240	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynA1562_00242	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynA1562_00246	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynA1562_00247	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynA1562_00249	COG0354	folic acid binding
SynA1562_00250	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynA1562_00253	COG1253	flavin adenine dinucleotide binding
SynA1562_00254	COG0673	inositol 2-dehydrogenase activity
SynA1562_00258	COG0343	queuine tRNA-ribosyltransferase activity
SynA1562_00260	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SynA1562_00266	COG0138	bifunctional purine biosynthesis protein purh
SynA1562_00269	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynA1562_00270	COG0004	ammonium transporteR
SynA1562_00271	COG1489	DNA binding
SynA1562_00272	COG0728	peptidoglycan biosynthetic process
SynA1562_00277	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynA1562_00279	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA1562_00280	COG1058	Belongs to the CinA family
SynA1562_00280	COG1546	Belongs to the CinA family
SynA1562_00281	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynA1562_00282	COG0066	3-isopropylmalate dehydratase activity
SynA1562_00289	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynA1562_00290	COG0193	aminoacyl-tRNA hydrolase activity
SynA1562_00293	COG4372	Transposase
SynA1562_00294	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1562_00295	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynA1562_00297	COG0717	Belongs to the dCTP deaminase family
SynA1562_00299	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynA1562_00301	COG0741	lytic transglycosylase activity
SynA1562_00302	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynA1562_00305	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynA1562_00309	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynA1562_00313	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA1562_00314	COG1402	creatininase
SynA1562_00316	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynA1562_00317	COG2094	Belongs to the DNA glycosylase MPG family
SynA1562_00323	COG2094	Belongs to the DNA glycosylase MPG family
SynA1562_00324	COG0540	Belongs to the ATCase OTCase family
SynA1562_00330	COG3536	Protein conserved in bacteria
SynA1562_00331	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynA1562_00334	COG2046	Belongs to the sulfate adenylyltransferase family
SynA1562_00334	COG0529	Catalyzes the synthesis of activated sulfate
SynA1562_00335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1562_00338	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynA1562_00342	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA1562_00344	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynA1562_00345	COG0436	Aminotransferase
SynA1562_00347	COG1530	ribonuclease E activity
SynA1562_00348	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynA1562_00351	COG2226	methyltransferase
SynA1562_00352	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynA1562_00353	COG0051	transcription antitermination factor activity, RNA binding
SynA1562_00354	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynA1562_00355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynA1562_00356	COG0049	tRNA binding
SynA1562_00357	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynA1562_00358	COG0316	Belongs to the HesB IscA family
SynA1562_00360	COG0067	glutamate synthase
SynA1562_00360	COG0070	glutamate synthase
SynA1562_00360	COG0069	glutamate synthase activity
SynA1562_00362	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynA1562_00366	COG2885	chlorophyll binding
SynA1562_00367	COG2885	chlorophyll binding
SynA1562_00375	COG0463	Glycosyl transferase, family 2
SynA1562_00379	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynA1562_00381	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynA1562_00382	COG0254	rRNA binding
SynA1562_00383	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynA1562_00384	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynA1562_00385	COG0101	tRNA pseudouridine synthase activity
SynA1562_00387	COG0203	ribosomal protein L17
SynA1562_00388	COG0202	RNA polymerase activity
SynA1562_00389	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynA1562_00390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynA1562_00391	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynA1562_00392	COG0563	adenylate kinase activity
SynA1562_00393	COG0201	protein transport
SynA1562_00394	COG0200	Binds to the 23S rRNA
SynA1562_00395	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynA1562_00396	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynA1562_00397	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynA1562_00398	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynA1562_00399	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynA1562_00400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynA1562_00401	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynA1562_00402	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynA1562_00403	COG0255	Belongs to the universal ribosomal protein uL29 family
SynA1562_00404	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynA1562_00405	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynA1562_00406	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynA1562_00407	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynA1562_00408	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynA1562_00409	COG0089	rRNA binding
SynA1562_00410	COG0088	Forms part of the polypeptide exit tunnel
SynA1562_00411	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynA1562_00414	COG3854	ATPases associated with a variety of cellular activities
SynA1562_00417	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynA1562_00422	COG1233	COG1233 Phytoene dehydrogenase and related
SynA1562_00423	COG3001	Fructosamine kinase
SynA1562_00427	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynA1562_00428	COG1606	tRNA processing
SynA1562_00429	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynA1562_00430	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynA1562_00433	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynA1562_00434	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynA1562_00435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynA1562_00438	COG0772	Belongs to the SEDS family
SynA1562_00439	COG0489	protein tyrosine kinase activity
SynA1562_00440	COG0408	coproporphyrinogen oxidase activity
SynA1562_00444	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SynA1562_00452	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynA1562_00453	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynA1562_00454	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynA1562_00454	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynA1562_00455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynA1562_00491	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1562_00501	COG1070	Carbohydrate kinase
SynA1562_00502	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynA1562_00504	COG0539	negative regulation of cytoplasmic translation
SynA1562_00505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynA1562_00510	COG0589	response to stress
SynA1562_00512	COG0758	DNA mediated transformation
SynA1562_00512	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynA1562_00513	COG2890	protein-(glutamine-N5) methyltransferase activity
SynA1562_00514	COG0009	L-threonylcarbamoyladenylate synthase
SynA1562_00518	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynA1562_00519	COG2894	cell division
SynA1562_00520	COG0850	regulation of cytokinetic process
SynA1562_00521	COG1078	dGTPase activity
SynA1562_00522	COG0793	Belongs to the peptidase S41A family
SynA1562_00523	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynA1562_00524	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynA1562_00533	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynA1562_00534	COG0235	Class ii aldolase
SynA1562_00535	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynA1562_00536	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynA1562_00539	COG0514	ATP-dependent DNA helicase (RecQ)
SynA1562_00540	COG1388	LysM domain
SynA1562_00540	COG3942	CHAP domain
SynA1562_00541	COG1012	belongs to the aldehyde dehydrogenase family
SynA1562_00547	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynA1562_00548	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynA1562_00552	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynA1562_00554	COG0659	secondary active sulfate transmembrane transporter activity
SynA1562_00555	COG4243	Vitamin k epoxide reductase
SynA1562_00556	COG0484	heat shock protein binding
SynA1562_00557	COG0113	porphobilinogen synthase activity
SynA1562_00559	COG1193	negative regulation of DNA recombination
SynA1562_00560	COG3842	ATPase activity
SynA1562_00561	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynA1562_00564	COG0488	(ABC) transporter
SynA1562_00566	COG0435	Glutathione S-transferase
SynA1562_00567	COG2988	succinylglutamate desuccinylase activity
SynA1562_00602	COG0582	viral genome integration into host DNA
SynA1562_00606	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynA1562_00608	COG1185	polyribonucleotide nucleotidyltransferase activity
SynA1562_00609	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynA1562_00610	COG0750	zinc metalloprotease
SynA1562_00611	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynA1562_00613	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1562_00615	COG0706	membrane insertase activity
SynA1562_00617	COG0594	ribonuclease P activity
SynA1562_00618	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynA1562_00621	COG0616	signal peptide processing
SynA1562_00622	COG0697	spore germination
SynA1562_00624	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynA1562_00626	COG1842	Phage shock protein A
SynA1562_00627	COG3118	belongs to the thioredoxin family
SynA1562_00628	COG0436	Aminotransferase
SynA1562_00631	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SynA1562_00631	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SynA1562_00632	COG0739	heme binding
SynA1562_00633	COG0745	RESPONSE REGULATOR receiver
SynA1562_00635	COG0577	efflux transmembrane transporter activity
SynA1562_00635	COG1136	(ABC) transporter
SynA1562_00636	COG1007	ATP synthesis coupled electron transport
SynA1562_00637	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynA1562_00640	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynA1562_00646	COG1845	cytochrome c oxidase, subunit III
SynA1562_00648	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynA1562_00649	COG1612	heme a metabolic process
SynA1562_00650	COG0109	protoheme IX farnesyltransferase activity
SynA1562_00654	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynA1562_00655	COG0459	protein refolding
SynA1562_00657	COG1028	Short-chain dehydrogenase reductase Sdr
SynA1562_00660	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynA1562_00661	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynA1562_00662	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynA1562_00667	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynA1562_00668	COG0739	heme binding
SynA1562_00669	COG0723	plastoquinol--plastocyanin reductase activity
SynA1562_00671	COG0805	protein transport
SynA1562_00672	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynA1562_00673	COG0194	GDP metabolic process
SynA1562_00676	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynA1562_00677	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1562_00679	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SynA1562_00683	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA1562_00687	COG0335	large ribosomal subunit rRNA binding
SynA1562_00689	COG0024	Methionine aminopeptidase
SynA1562_00690	COG0300	oxidoreductase activity
SynA1562_00690	COG3000	fatty acid hydroxylase
SynA1562_00692	COG0857	belongs to the CobB CobQ family
SynA1562_00695	COG1666	GTP binding
SynA1562_00698	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SynA1562_00700	COG0295	cytidine deaminase activity
SynA1562_00702	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynA1562_00704	COG0277	FAD linked oxidase domain protein
SynA1562_00705	COG0708	Exodeoxyribonuclease III
SynA1562_00709	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1562_00710	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynA1562_00714	COG3842	ATPase activity
SynA1562_00716	COG0523	cobalamin synthesis protein
SynA1562_00717	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynA1562_00718	COG0432	Pfam Uncharacterised protein family UPF0047
SynA1562_00722	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynA1562_00724	COG0181	hydroxymethylbilane synthase activity
SynA1562_00726	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1562_00727	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynA1562_00729	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynA1562_00735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynA1562_00736	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynA1562_00738	COG0442	prolyl-tRNA aminoacylation
SynA1562_00741	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynA1562_00747	COG0588	phosphoglycerate mutase activity
SynA1562_00750	COG0768	penicillin binding
SynA1562_00751	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynA1562_00755	COG0415	Belongs to the DNA photolyase family
SynA1562_00757	COG0233	cytoplasmic translational termination
SynA1562_00758	COG0528	UMP kinase activity
SynA1562_00761	COG2226	methyltransferase
SynA1562_00763	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1562_00764	COG0028	Belongs to the TPP enzyme family
SynA1562_00768	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynA1562_00772	COG0539	negative regulation of cytoplasmic translation
SynA1562_00774	COG3396	Phenylacetate-CoA oxygenase
SynA1562_00775	COG5322	oxidoreductase activity
SynA1562_00776	COG0825	malonyl-CoA metabolic process
SynA1562_00778	COG0302	gtp cyclohydrolase
SynA1562_00779	COG0135	phosphoribosylanthranilate isomerase activity
SynA1562_00780	COG1994	Peptidase M50
SynA1562_00780	COG0517	IMP dehydrogenase activity
SynA1562_00781	COG0095	Lipoate-protein ligase
SynA1562_00782	COG0730	response to heat
SynA1562_00787	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynA1562_00789	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynA1562_00790	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynA1562_00792	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA1562_00793	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynA1562_00794	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA1562_00795	COG1850	ribulose-bisphosphate carboxylase activity
SynA1562_00796	COG4451	ribulose bisphosphate carboxylase, small
SynA1562_00801	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA1562_00802	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynA1562_00803	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1562_00809	COG1492	cobalamin metabolic process
SynA1562_00811	COG0424	maF-like protein
SynA1562_00818	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynA1562_00819	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SynA1562_00821	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynA1562_00831	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynA1562_00832	COG0579	oxidoreductase
SynA1562_00834	COG0481	GTPase activity
SynA1562_00838	COG5002	protein histidine kinase activity
SynA1562_00840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SynA1562_00843	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1562_00844	COG3695	enzyme binding
SynA1562_00845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynA1562_00845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynA1562_00846	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynA1562_00847	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynA1562_00849	COG0107	imidazoleglycerol-phosphate synthase activity
SynA1562_00850	COG2226	methyltransferase
SynA1562_00854	COG0752	glycyl-tRNA synthetase alpha subunit
SynA1562_00864	COG0028	Belongs to the TPP enzyme family
SynA1562_00868	COG1234	tRNA 3'-trailer cleavage
SynA1562_00869	COG3659	wide pore channel activity
SynA1562_00872	COG0438	transferase activity, transferring glycosyl groups
SynA1562_00873	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynA1562_00874	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynA1562_00875	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynA1562_00876	COG0740	serine-type endopeptidase activity
SynA1562_00877	COG0740	serine-type endopeptidase activity
SynA1562_00878	COG4956	integral membrane protein (PIN domain superfamily)
SynA1562_00879	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynA1562_00882	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynA1562_00883	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynA1562_00886	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynA1562_00887	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA1562_00888	COG4948	Mandelate Racemase Muconate Lactonizing
SynA1562_00895	COG0285	dihydrofolate synthase activity
SynA1562_00896	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynA1562_00897	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynA1562_00898	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynA1562_00901	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1562_00902	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynA1562_00903	COG0134	indole-3-glycerol-phosphate synthase activity
SynA1562_00909	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynA1562_00910	COG0482	sulfurtransferase activity
SynA1562_00911	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynA1562_00911	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynA1562_00912	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1562_00913	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynA1562_00916	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynA1562_00917	COG0228	four-way junction DNA binding
SynA1562_00918	COG1702	phosphate starvation-inducible protein PhoH
SynA1562_00919	COG0670	Belongs to the BI1 family
SynA1562_00921	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynA1562_00924	COG0336	Belongs to the RNA methyltransferase TrmD family
SynA1562_00926	COG1691	(AIR) carboxylase
SynA1562_00930	COG0352	thiamine-phosphate diphosphorylase activity
SynA1562_00931	COG0196	riboflavin kinase activity
SynA1562_00934	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynA1562_00935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynA1562_00938	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynA1562_00947	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynA1562_00947	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynA1562_00949	COG2135	peptidase activity
SynA1562_00950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1562_00951	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynA1562_00954	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynA1562_00962	COG4974	Belongs to the 'phage' integrase family
SynA1562_00975	COG0251	oxidation-reduction process
SynA1562_00976	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynA1562_00977	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynA1562_00978	COG1132	(ABC) transporter
SynA1562_00979	COG0456	acetyltransferase
SynA1562_00980	COG1215	transferase activity, transferring glycosyl groups
SynA1562_00982	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1562_00983	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynA1562_00988	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynA1562_00990	COG3961	Belongs to the TPP enzyme family
SynA1562_00991	COG1845	cytochrome c oxidase, subunit III
SynA1562_00992	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynA1562_00993	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynA1562_00996	COG0530	calcium, potassium:sodium antiporter activity
SynA1562_00997	COG0659	secondary active sulfate transmembrane transporter activity
SynA1562_00998	COG0418	dihydroorotase activity
SynA1562_01003	COG0159	tryptophan synthase activity
SynA1562_01006	COG2010	Cytochrome c
SynA1562_01013	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1562_01017	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynA1562_01017	COG0140	phosphoribosyl-ATP diphosphatase activity
SynA1562_01020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SynA1562_01021	COG0542	response to heat
SynA1562_01036	COG3794	PFAM blue (type 1) copper domain protein
SynA1562_01038	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynA1562_01039	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynA1562_01047	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynA1562_01050	COG0339	signal peptide processing
SynA1562_01051	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1562_01052	COG0083	homoserine kinase activity
SynA1562_01053	COG0837	glucose binding
SynA1562_01055	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynA1562_01058	COG0180	Tryptophanyl-tRNA synthetase
SynA1562_01086	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynA1562_01106	COG1116	anion transmembrane transporter activity
SynA1562_01107	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynA1562_01110	COG0375	protein maturation
SynA1562_01111	COG0010	Belongs to the arginase family
SynA1562_01120	COG0484	heat shock protein binding
SynA1562_01136	COG3659	wide pore channel activity
SynA1562_01137	COG3659	wide pore channel activity
SynA1562_01148	COG0681	Belongs to the peptidase S26 family
SynA1562_01149	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynA1562_01150	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynA1562_01151	COG1376	ErfK ybiS ycfS ynhG family protein
SynA1562_01152	COG0297	glycogen (starch) synthase activity
SynA1562_01154	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynA1562_01155	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynA1562_01157	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynA1562_01158	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynA1562_01159	COG2045	Belongs to the ComB family
SynA1562_01161	COG0860	N-Acetylmuramoyl-L-alanine amidase
SynA1562_01162	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynA1562_01163	COG0142	geranyltranstransferase activity
SynA1562_01164	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynA1562_01165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynA1562_01167	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1562_01168	COG2176	DNA-directed DNA polymerase activity
SynA1562_01172	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1562_01177	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1562_01182	COG1132	(ABC) transporter
SynA1562_01183	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynA1562_01184	COG0505	Belongs to the CarA family
SynA1562_01186	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynA1562_01187	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1562_01189	COG0154	amidase activity
SynA1562_01190	COG0587	DNA-directed DNA polymerase activity
SynA1562_01192	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynA1562_01193	COG0632	four-way junction helicase activity
SynA1562_01194	COG1006	Multisubunit Na H antiporter MnhC subunit
SynA1562_01201	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1562_01202	COG1809	phosphosulfolactate synthase activity
SynA1562_01207	COG0358	DNA primase activity
SynA1562_01211	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynA1562_01215	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynA1562_01219	COG0792	nuclease activity
SynA1562_01220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynA1562_01221	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynA1562_01223	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynA1562_01223	COG0022	dehydrogenase e1 component
SynA1562_01224	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynA1562_01225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynA1562_01230	COG0628	permease
SynA1562_01232	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynA1562_01233	COG0515	serine threonine protein kinase
SynA1562_01238	COG2226	methyltransferase
SynA1562_01239	COG0174	glutamine synthetase
SynA1562_01241	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynA1562_01245	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynA1562_01249	COG0612	Peptidase, M16
SynA1562_01255	COG1216	Glycosyl transferase, family 2
SynA1562_01256	COG0052	Belongs to the universal ribosomal protein uS2 family
SynA1562_01257	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynA1562_01259	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynA1562_01260	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynA1562_01261	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynA1562_01262	COG0751	glycine-tRNA ligase activity
SynA1562_01264	COG0644	oxidoreductase
SynA1562_01266	COG0826	peptidase U32
SynA1562_01267	COG1217	gtp-binding protein TYPA
SynA1562_01272	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynA1562_01278	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynA1562_01279	COG1494	fructose-1,6-bisphosphatase
SynA1562_01280	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynA1562_01281	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1562_01282	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynA1562_01283	COG0363	glucosamine-6-phosphate deaminase activity
SynA1562_01286	COG0129	dihydroxy-acid dehydratase activity
SynA1562_01288	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynA1562_01289	COG1357	PFAM Pentapeptide repeats (8 copies)
SynA1562_01296	COG0300	oxidoreductase activity
SynA1562_01304	COG4106	trans-aconitate 2-methyltransferase activity
SynA1562_01305	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynA1562_01308	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynA1562_01309	COG1122	ATPase activity
SynA1562_01313	COG1836	PFAM Integral membrane protein DUF92
SynA1562_01314	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1562_01319	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA1562_01319	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynA1562_01320	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynA1562_01321	COG0436	Aminotransferase
SynA1562_01323	COG1573	uracil-dna glycosylase
SynA1562_01324	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynA1562_01325	COG0793	Belongs to the peptidase S41A family
SynA1562_01327	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynA1562_01334	COG0861	Integral membrane protein TerC family
SynA1562_01337	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynA1562_01339	COG0312	modulator of DNA gyrase
SynA1562_01340	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynA1562_01343	COG0163	prenyltransferase activity
SynA1562_01344	COG0557	exoribonuclease II activity
SynA1562_01346	COG2119	membrane
SynA1562_01349	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynA1562_01349	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynA1562_01350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynA1562_01353	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynA1562_01354	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1562_01355	COG1615	UPF0182 protein
SynA1562_01356	COG0450	alkyl hydroperoxide reductase
SynA1562_01359	COG0739	heme binding
SynA1562_01360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynA1562_01366	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynA1562_01368	COG0557	exoribonuclease II activity
SynA1562_01369	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynA1562_01370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynA1562_01371	COG0072	phenylalanine-tRNA ligase activity
SynA1562_01372	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynA1562_01382	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1562_01384	COG2385	sporulation resulting in formation of a cellular spore
SynA1562_01389	COG1410	methionine synthase
SynA1562_01389	COG0646	methionine synthase
SynA1562_01390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynA1562_01394	COG1981	membrane
SynA1562_01395	COG3046	protein related to deoxyribodipyrimidine photolyase
SynA1562_01397	COG0322	excinuclease ABC activity
SynA1562_01399	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynA1562_01404	COG1104	cysteine desulfurase activity
SynA1562_01405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynA1562_01407	COG0495	leucyl-tRNA aminoacylation
SynA1562_01408	COG0166	Belongs to the GPI family
SynA1562_01416	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynA1562_01417	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynA1562_01419	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynA1562_01419	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynA1562_01420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1562_01421	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynA1562_01422	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynA1562_01424	COG0484	heat shock protein binding
SynA1562_01425	COG0443	Heat shock 70 kDa protein
SynA1562_01426	COG0573	inorganic phosphate transmembrane transporter activity
SynA1562_01427	COG0581	inorganic phosphate transmembrane transporter activity
SynA1562_01428	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynA1562_01430	COG3217	Mosc domain protein beta barrel domain protein
SynA1562_01430	COG0633	Ferredoxin
SynA1562_01431	COG0483	inositol monophosphate 1-phosphatase activity
SynA1562_01432	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynA1562_01434	COG0326	Molecular chaperone. Has ATPase activity
SynA1562_01435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynA1562_01436	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1562_01437	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynA1562_01438	COG1653	transport
SynA1562_01439	COG1175	transmembrane transport
SynA1562_01446	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynA1562_01447	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynA1562_01448	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynA1562_01453	COG0469	pyruvate kinase activity
SynA1562_01454	COG0577	efflux transmembrane transporter activity
SynA1562_01454	COG1136	(ABC) transporter
SynA1562_01455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1562_01456	COG0740	serine-type endopeptidase activity
SynA1562_01461	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynA1562_01470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynA1562_01471	COG1175	transmembrane transport
SynA1562_01472	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynA1562_01479	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SynA1562_01484	COG1793	dna ligase
SynA1562_01485	COG1201	RNA secondary structure unwinding
SynA1562_01501	COG2226	methyltransferase
SynA1562_01508	COG1119	ATPase activity
SynA1562_01511	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA1562_01513	COG1121	(ABC) transporter
SynA1562_01514	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynA1562_01515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynA1562_01516	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA1562_01538	COG2032	superoxide dismutase activity
SynA1562_01542	COG0724	RNA recognition motif
SynA1562_01544	COG0463	Glycosyl transferase, family 2
SynA1562_01568	COG2124	cytochrome p450
SynA1562_01584	COG1611	Belongs to the LOG family
SynA1562_01585	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SynA1562_01625	COG0405	Gamma-glutamyltransferase
SynA1562_01639	COG0523	cobalamin synthesis protein
SynA1562_01647	COG3659	wide pore channel activity
SynA1562_01649	COG3128	pkhd-type hydroxylase
SynA1562_01650	COG1840	ABC-type Fe3 transport system, periplasmic component
SynA1562_01652	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA1562_01656	COG0492	ferredoxin-NADP+ reductase activity
SynA1562_01657	COG0716	FMN binding
SynA1562_01663	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynA1562_01671	COG3659	wide pore channel activity
SynA1562_01685	COG0701	Predicted permease
SynA1562_01690	COG1121	(ABC) transporter
SynA1562_01691	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA1562_01698	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynA1562_01699	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynA1562_01700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynA1562_01701	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynA1562_01703	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynA1562_01706	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynA1562_01710	COG1640	4-alpha-glucanotransferase
SynA1562_01711	COG1187	pseudouridine synthase activity
SynA1562_01712	COG5002	protein histidine kinase activity
SynA1562_01713	COG0745	RESPONSE REGULATOR receiver
SynA1562_01715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1562_01716	COG1982	Orn Lys Arg decarboxylase major
SynA1562_01717	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynA1562_01718	COG0575	Belongs to the CDS family
SynA1562_01720	COG0596	Alpha beta hydrolase
SynA1562_01720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SynA1562_01720	COG2226	methyltransferase
SynA1562_01721	COG0371	Dehydrogenase
SynA1562_01722	COG0542	response to heat
SynA1562_01724	COG0019	diaminopimelate decarboxylase activity
SynA1562_01725	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynA1562_01726	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynA1562_01727	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynA1562_01731	COG1054	Belongs to the UPF0176 family
SynA1562_01734	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynA1562_01735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynA1562_01738	COG0475	glutathione-regulated potassium exporter activity
SynA1562_01738	COG0589	response to stress
SynA1562_01739	COG1132	(ABC) transporter
SynA1562_01741	COG0724	RNA recognition motif
SynA1562_01745	COG0513	Belongs to the DEAD box helicase family
SynA1562_01747	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynA1562_01752	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynA1562_01753	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynA1562_01756	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynA1562_01760	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynA1562_01763	COG0271	Belongs to the BolA IbaG family
SynA1562_01764	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynA1562_01766	COG0745	RESPONSE REGULATOR receiver
SynA1562_01780	COG0463	Glycosyl transferase, family 2
SynA1562_01781	COG0297	glycogen (starch) synthase activity
SynA1562_01784	COG0438	transferase activity, transferring glycosyl groups
SynA1562_01785	COG0438	transferase activity, transferring glycosyl groups
SynA1562_01789	COG1132	(ABC) transporter
SynA1562_01793	COG1596	polysaccharide export
SynA1562_01794	COG0489	protein tyrosine kinase activity
SynA1562_01799	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynA1562_01801	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynA1562_01868	COG0786	glutamate:sodium symporter activity
SynA1562_01869	COG2197	response regulator
SynA1562_01886	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynA1562_01893	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SynA1562_01896	COG0735	belongs to the Fur family
SynA1562_01913	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynA1562_01922	COG1126	abc transporter atp-binding protein
SynA1562_01923	COG0765	amino acid transport
SynA1562_01924	COG4597	amino acid ABC transporter
SynA1562_01925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynA1562_01927	COG0659	secondary active sulfate transmembrane transporter activity
SynA1562_01936	COG0799	negative regulation of ribosome biogenesis
SynA1562_01938	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynA1562_01940	COG1115	amino acid carrier protein
SynA1562_01942	COG1132	(ABC) transporter
SynA1562_01944	COG0149	triose-phosphate isomerase activity
SynA1562_01945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynA1562_01948	COG1429	ligase activity, forming nitrogen-metal bonds
SynA1562_01950	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynA1562_01952	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1562_01955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynA1562_01967	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA1562_01968	COG0640	Transcriptional regulator
SynA1562_01970	COG0668	transmembrane transport
SynA1562_01973	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynA1562_01974	COG0047	phosphoribosylformylglycinamidine synthase activity
SynA1562_01975	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynA1562_01977	COG0191	fructose-bisphosphate aldolase activity
SynA1562_01978	COG0673	inositol 2-dehydrogenase activity
SynA1562_01980	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynA1562_01981	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynA1562_01983	COG3954	Phosphoribulokinase
SynA1562_01984	COG0473	3-isopropylmalate dehydrogenase activity
SynA1562_01985	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1562_01986	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynA1562_01989	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynA1562_01992	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynA1562_01993	COG2197	response regulator
SynA1562_01995	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynA1562_02000	COG1376	ErfK ybiS ycfS ynhG family protein
SynA1562_02006	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA1562_02023	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1562_02025	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynA1562_02039	COG0308	aminopeptidase N
SynA1562_02043	COG2205	protein histidine kinase activity
SynA1562_02048	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynA1562_02050	COG1797	cobyrinic acid a,c-diamide synthase activity
SynA1562_02051	COG1254	Belongs to the acylphosphatase family
SynA1562_02055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynA1562_02059	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynA1562_02060	COG1480	7TM receptor with intracellular HD hydrolase
SynA1562_02062	COG0564	pseudouridine synthase activity
SynA1562_02064	COG0011	TIGRFAM Protein of
SynA1562_02070	COG0395	ABC-type sugar transport system, permease component
SynA1562_02071	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynA1562_02072	COG1543	Belongs to the glycosyl hydrolase 57 family
SynA1562_02073	COG0644	oxidoreductase
SynA1562_02074	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynA1562_02075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA1562_02076	COG0516	GMP reductase activity
SynA1562_02077	COG3118	belongs to the thioredoxin family
SynA1562_02078	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynA1562_02079	COG0742	ribosomal rna small subunit methyltransferase
SynA1562_02081	COG2010	Cytochrome c
SynA1562_02082	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SynA1562_02085	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1562_02086	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynA1562_02087	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynA1562_02089	COG2166	iron-sulfur cluster assembly
SynA1562_02090	COG0460	homoserine dehydrogenase
SynA1562_02092	COG0747	negative chemotaxis
SynA1562_02093	COG0601	transmembrane transport
SynA1562_02097	COG0012	GTP binding
SynA1562_02098	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynA1562_02099	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynA1562_02099	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynA1562_02100	COG0215	cysteine-tRNA ligase activity
SynA1562_02102	COG0733	neurotransmitter:sodium symporter activity
SynA1562_02103	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynA1562_02104	COG3411	Ferredoxin
SynA1562_02114	COG0492	ferredoxin-NADP+ reductase activity
SynA1562_02115	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynA1562_02117	COG2226	methyltransferase
SynA1562_02119	COG0702	epimerase
SynA1562_02122	COG2267	carboxylic ester hydrolase activity
SynA1562_02123	COG0440	acetolactate synthase activity
SynA1562_02124	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1562_02131	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynA1562_02132	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynA1562_02143	COG1022	Amp-dependent synthetase and ligase
SynA1562_02144	COG0321	lipoyl(octanoyl) transferase activity
SynA1562_02145	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynA1562_02146	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynA1562_02147	COG1381	Involved in DNA repair and RecF pathway recombination
SynA1562_02149	COG0438	transferase activity, transferring glycosyl groups
SynA1562_02153	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynA1562_02155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynA1562_02156	COG1799	cell septum assembly
SynA1562_02157	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynA1562_02159	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynA1562_02160	COG1160	GTP binding
SynA1562_02161	COG1376	ErfK ybiS ycfS ynhG family protein
SynA1562_02163	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynA1562_02168	COG1088	dTDP-glucose 4,6-dehydratase activity
SynA1562_02174	COG0114	fumarate hydratase activity
SynA1562_02175	COG4581	dead DEAH box helicase
SynA1562_02183	COG0385	Bile acid
SynA1562_02184	COG0156	8-amino-7-oxononanoate synthase activity
SynA1562_02187	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynA1562_02190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynA1562_02193	COG0357	Ribosomal RNA small subunit methyltransferase G
SynA1562_02201	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynA1562_02202	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1562_02203	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynA1562_02204	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynA1562_02205	COG0085	RNA polymerase activity
SynA1562_02206	COG0084	hydrolase, TatD family'
SynA1562_02207	COG0268	Binds directly to 16S ribosomal RNA
SynA1562_02208	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynA1562_02209	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynA1562_02210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1562_02214	COG0641	radical SAM
SynA1562_02217	COG0779	Required for maturation of 30S ribosomal subunits
SynA1562_02218	COG0195	Participates in both transcription termination and antitermination
SynA1562_02220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynA1562_02227	COG1053	succinate dehydrogenase
SynA1562_02233	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA1562_02235	COG0776	regulation of translation
SynA1562_02239	COG2211	Major facilitator Superfamily
SynA1562_02240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynA1562_02243	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynA1562_02244	COG0284	orotidine-5'-phosphate decarboxylase activity
SynA1562_02246	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynA1562_02253	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynA1562_02263	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1562_02265	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1562_02266	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynA1562_02267	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynA1562_02269	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynA1562_02271	COG0151	Belongs to the GarS family
SynA1562_02272	COG5002	protein histidine kinase activity
SynA1562_02273	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynA1562_02274	COG4251	negative regulation of phosphorylation
SynA1562_02276	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynA1562_02277	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynA1562_02279	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynA1562_02280	COG0217	transcriptional regulatory protein
SynA1562_02283	COG0363	glucosamine-6-phosphate deaminase activity
SynA1562_02284	COG2385	sporulation resulting in formation of a cellular spore
SynA1562_02284	COG2247	cell wall binding repeat
SynA1562_02285	COG1234	tRNA 3'-trailer cleavage
SynA1562_02286	COG2010	Cytochrome c
SynA1562_02289	COG2264	protein methyltransferase activity
SynA1562_02290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynA1562_02294	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynA1562_02302	COG0443	Heat shock 70 kDa protein
SynA1562_02305	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynA1562_02306	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynA1562_02312	COG0459	protein refolding
SynA1562_02313	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynA1562_02314	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynA1562_02315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynA1562_02319	COG0387	Pfam Sodium calcium exchanger
SynA1562_02320	COG0006	proline dipeptidase activity
SynA1562_02321	COG1253	flavin adenine dinucleotide binding
SynA1562_02322	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynA1562_02323	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynA1562_02324	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynA1562_02324	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynA1562_02325	COG0686	Belongs to the AlaDH PNT family
SynA1562_02326	COG3012	SEC-C Motif Domain Protein
SynA1562_02327	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynA1562_02329	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA1562_02331	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynA1562_02332	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynA1562_02333	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynA1562_02334	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynA1562_02335	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynA1562_02336	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynA1562_02337	COG0356	it plays a direct role in the translocation of protons across the membrane
SynA1562_02339	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1562_02340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1562_02346	COG0772	Belongs to the SEDS family
SynA1562_02348	COG1333	cytochrome c biogenesis protein
SynA1562_02349	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynA1562_02352	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynA1562_02355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynA1562_02357	COG3562	capsule polysaccharide
SynA1562_02363	COG2089	acid synthase
SynA1562_02385	COG0590	tRNA wobble adenosine to inosine editing
SynA1562_02397	COG0116	Belongs to the methyltransferase superfamily
SynA1562_02402	COG1196	nuclear chromosome segregation
SynA1562_02404	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1562_02405	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1562_02408	COG0439	Biotin carboxylase
SynA1562_02411	COG0515	serine threonine protein kinase
SynA1562_02414	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1562_02415	COG4178	(ABC) transporter
SynA1562_02416	COG0537	adenosine 5'-monophosphoramidase activity
SynA1562_02417	COG0606	chelatase, subunit chli
SynA1562_02418	COG0606	chelatase, subunit chli
SynA1562_02419	COG0606	chelatase, subunit chli
SynA1562_02423	COG0242	peptide deformylase activity
SynA1562_02426	COG1970	mechanosensitive ion channel activity
SynA1562_02428	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynA1562_02429	COG0719	Fe-S assembly protein
SynA1562_02430	COG0396	ATPase activity
SynA1562_02431	COG0719	Fe-S assembly protein
SynA1562_02432	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynA1562_02436	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1562_02442	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1562_02447	COG0033	Phosphoglucomutase
SynA1562_02453	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynA1562_02455	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SynA1562_02458	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1562_02459	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynA1562_02460	COG0175	sulfate reduction
SynA1562_02461	COG1252	NADH dehydrogenase
SynA1562_02462	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynA1562_02463	COG0471	metal ion transport
SynA1562_02463	COG3273	potassium ion transport
SynA1562_02464	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynA1562_02465	COG0569	domain protein
SynA1562_02466	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynA1562_02471	COG0488	(ABC) transporter
SynA1562_02473	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1562_02476	COG1643	Atp-dependent helicase
SynA1562_02479	COG1570	exodeoxyribonuclease VII activity
SynA1562_02493	COG1968	undecaprenyl-diphosphatase activity
SynA1562_02495	COG1555	photosystem II stabilization
SynA1562_02496	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynA1562_02497	COG4243	Vitamin k epoxide reductase
SynA1562_02498	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA1562_02502	COG1032	radical SAM domain protein
SynA1562_02507	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynA1562_02512	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynA1562_02513	COG1472	Belongs to the glycosyl hydrolase 3 family
SynA1562_02514	COG0463	Glycosyl transferase, family 2
SynA1562_02514	COG0457	Tetratricopeptide repeat
SynA1562_02515	COG1587	Uroporphyrinogen-III synthase
SynA1562_02518	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynA1562_02519	COG0316	Belongs to the HesB IscA family
SynA1562_02523	COG1090	epimerase
SynA1562_02526	COG0484	heat shock protein binding
SynA1562_02527	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynA1562_02528	COG3659	wide pore channel activity
SynA1562_02529	COG3659	wide pore channel activity
SynA1562_02539	COG1122	ATPase activity
SynA1562_02541	COG0745	RESPONSE REGULATOR receiver
SynA1562_02543	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynA1562_02544	COG2217	Heavy metal translocating P-type atpase
SynA1562_02545	COG3063	Type IV pilus biogenesis stability protein PilW
SynA1562_02546	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynA1562_02548	COG0416	fatty acid biosynthetic process
SynA1562_02549	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynA1562_02550	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynA1562_02551	COG0204	Acyl-transferase
SynA1562_02551	COG0318	PFAM AMP-dependent synthetase and ligase
SynA1562_02553	COG1214	PFAM Peptidase M22, glycoprotease
SynA1562_02555	COG0617	tRNA 3'-terminal CCA addition
SynA1562_02556	COG0724	RNA recognition motif
SynA1562_02557	COG1562	ergosterol biosynthetic process
SynA1562_02558	COG0493	'glutamate synthase
SynA1562_02558	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynA1562_02561	COG0583	DNA-binding transcription factor activity
SynA1562_02563	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynA1562_02564	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1562_02567	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynA1562_02569	COG2197	response regulator
SynA1562_02572	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynA1562_02573	COG0713	ATP synthesis coupled electron transport
SynA1562_02574	COG0839	Belongs to the complex I subunit 6 family
SynA1562_02575	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1562_02576	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynA1562_02577	COG0372	Belongs to the citrate synthase family
SynA1562_02580	COG1054	Belongs to the UPF0176 family
SynA1562_02581	COG1420	regulation of RNA biosynthetic process
SynA1562_02582	COG1420	regulation of RNA biosynthetic process
SynA1562_02583	COG0133	tryptophan synthase activity
SynA1562_02584	COG0023	Translation Initiation Factor
SynA1562_02585	COG0529	Catalyzes the synthesis of activated sulfate
SynA1562_02586	COG0628	permease
SynA1562_02588	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynA1562_02590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1562_02591	COG0564	pseudouridine synthase activity
SynA1562_02592	COG0745	RESPONSE REGULATOR receiver
SynA1562_02594	COG1104	cysteine desulfurase activity
SynA1562_02597	COG0275	rRNA processing
SynA1562_02598	COG0649	NAD binding
SynA1562_02601	COG0824	Thioesterase
SynA1562_02603	COG4948	Mandelate Racemase Muconate Lactonizing
SynA1562_02604	COG1575	Belongs to the MenA family. Type 1 subfamily
SynA1562_02606	COG0189	ligase activity
SynA1562_02607	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynA1562_02608	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynA1562_02610	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynA1562_02611	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynA1562_02615	COG0252	asparaginase activity
SynA1562_02616	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynA1562_02617	COG0018	arginyl-trna synthetase
SynA1562_02618	COG0157	Belongs to the NadC ModD family
SynA1562_02619	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynA1562_02621	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynA1562_02622	COG4172	Belongs to the ABC transporter superfamily
SynA1562_02623	COG0564	pseudouridine synthase activity
SynA1562_02624	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SynA1562_02625	COG0126	phosphoglycerate kinase activity
SynA1562_02629	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynA1562_02630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynA1562_02632	COG0167	dihydroorotate dehydrogenase activity
SynA1562_02633	COG0328	RNA-DNA hybrid ribonuclease activity
SynA1562_02635	COG0222	ribosome binding
SynA1562_02636	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynA1562_02637	COG0081	regulation of translation
SynA1562_02638	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynA1562_02639	COG0250	Participates in transcription elongation, termination and antitermination
SynA1562_02640	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynA1562_02641	COG0542	response to heat
SynA1562_02642	COG0346	lactoylglutathione lyase activity
SynA1562_02643	COG0148	phosphopyruvate hydratase activity
SynA1562_02644	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1562_02655	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SynA1562_02655	COG2755	lipolytic protein G-D-S-L family
SynA1562_02658	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynA1562_02660	COG0237	dephospho-CoA kinase activity
SynA1562_02662	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA1562_02663	COG2022	thiamine diphosphate biosynthetic process
SynA1562_02663	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynA1562_02664	COG0105	UTP biosynthetic process
SynA1562_02665	COG1166	arginine decarboxylase activity
SynA1562_02671	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynA1562_02673	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynA1562_02677	COG0071	Belongs to the small heat shock protein (HSP20) family
SynA1562_02679	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynA1562_02679	COG0426	domain, Protein
SynA1562_02681	COG0426	domain, Protein
SynA1562_02681	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynA1562_02686	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynA1562_02686	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynA1562_02687	COG0509	glycine decarboxylation via glycine cleavage system
SynA1562_02688	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynA1562_02690	COG0359	binds to the 23S rRNA
SynA1562_02691	COG0305	Participates in initiation and elongation during chromosome replication
SynA1562_02691	COG1372	Participates in initiation and elongation during chromosome replication
SynA1562_02691	COG1372	Participates in initiation and elongation during chromosome replication
SynA1562_02691	COG0305	Participates in initiation and elongation during chromosome replication
SynA1562_02694	COG0445	tRNA wobble uridine modification
SynA1562_02701	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynA1562_02703	COG0398	Pfam SNARE associated Golgi protein
SynA1562_02707	COG0668	transmembrane transport
SynA1562_02708	COG0525	valine-tRNA ligase activity
SynA1562_02714	COG4221	oxidoreductase activity
SynA1562_02726	COG3956	TIGRFAM MazG family protein
SynA1562_02727	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynA1562_02728	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynA1562_02729	COG0010	Belongs to the arginase family
SynA1562_02732	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynA1562_02733	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynA1562_02734	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1562_02735	COG0783	Belongs to the Dps family
SynA1562_02736	COG0504	CTP synthase activity
SynA1562_02737	COG0602	queuosine metabolic process
SynA1562_02738	COG2084	Dehydrogenase
SynA1562_02739	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynA1562_02743	COG0366	Alpha amylase catalytic
SynA1562_02744	COG0463	Glycosyl transferase, family 2
SynA1562_02753	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynA1562_02754	COG0830	nickel cation binding
SynA1562_02755	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynA1562_02756	COG0829	nickel cation binding
SynA1562_02757	COG0831	urea catabolic process
SynA1562_02758	COG0832	Belongs to the urease beta subunit family
SynA1562_02759	COG0804	urea catabolic process
SynA1562_02765	COG0367	asparagine synthase
SynA1562_02766	COG0540	Belongs to the ATCase OTCase family
SynA1562_02771	COG2308	Evidence 4 Homologs of previously reported genes of
SynA1562_02775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynA1562_02776	COG0746	molybdenum cofactor guanylyltransferase activity
SynA1562_02778	COG2223	nitrite transmembrane transporter activity
SynA1562_02779	COG0243	molybdopterin cofactor binding
SynA1562_02784	COG0315	cyclic pyranopterin monophosphate synthase activity
SynA1562_02785	COG0303	'Molybdopterin
SynA1562_02788	COG0314	molybdopterin synthase activity
SynA1562_02790	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynA1562_02791	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynA1562_02794	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynA1562_02796	COG2116	formate transmembrane transporter activity
SynA1562_02798	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynA1562_02800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynA1562_02803	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynA1562_02805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1562_02806	COG0170	dolichyl monophosphate biosynthetic process
SynA1562_02807	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynA1562_02808	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynA1562_02810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA1562_02812	COG0788	formyltetrahydrofolate deformylase activity
SynA1562_02817	COG0443	Heat shock 70 kDa protein
SynA1562_02818	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynA1562_02820	COG0360	Binds together with S18 to 16S ribosomal RNA
SynA1562_02822	COG0137	argininosuccinate synthase activity
SynA1562_02825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA1562_02831	COG1376	ErfK ybiS ycfS ynhG family protein
SynA1562_02832	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynA1562_02833	COG0438	transferase activity, transferring glycosyl groups
SynA1562_02836	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynA1562_02837	COG0497	DNA recombination
SynA1562_02838	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1562_02840	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine