locus-tag	class	description
SynA1840_00001	COG0592	DNA-directed DNA polymerase activity
SynA1840_00003	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynA1840_00004	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SynA1840_00005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynA1840_00007	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynA1840_00010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynA1840_00011	COG0552	protein localization to endoplasmic reticulum
SynA1840_00012	COG2208	phosphoserine phosphatase activity
SynA1840_00013	COG0165	Argininosuccinate lyase
SynA1840_00014	COG0724	RNA recognition motif
SynA1840_00015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynA1840_00016	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1840_00017	COG2081	HI0933 family
SynA1840_00018	COG1459	type II secretion system
SynA1840_00021	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynA1840_00023	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynA1840_00024	COG0484	heat shock protein binding
SynA1840_00026	COG1162	GTPase activity
SynA1840_00027	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynA1840_00028	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynA1840_00029	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynA1840_00031	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA1840_00032	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynA1840_00033	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1840_00034	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynA1840_00035	COG0511	ligase activity, forming carbon-carbon bonds
SynA1840_00036	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynA1840_00049	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynA1840_00050	COG0519	Catalyzes the synthesis of GMP from XMP
SynA1840_00050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynA1840_00053	COG0768	penicillin binding
SynA1840_00054	COG0438	transferase activity, transferring glycosyl groups
SynA1840_00057	COG2022	thiamine diphosphate biosynthetic process
SynA1840_00060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynA1840_00061	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynA1840_00062	COG2385	sporulation resulting in formation of a cellular spore
SynA1840_00063	COG1215	transferase activity, transferring glycosyl groups
SynA1840_00064	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynA1840_00066	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynA1840_00067	COG0740	serine-type endopeptidase activity
SynA1840_00068	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynA1840_00069	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynA1840_00070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynA1840_00071	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynA1840_00075	COG2082	Precorrin-8x methylmutase
SynA1840_00076	COG0037	tRNA processing
SynA1840_00078	COG0556	nucleotide-excision repair
SynA1840_00079	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynA1840_00083	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynA1840_00088	COG0653	protein targeting
SynA1840_00092	COG1045	serine acetyltransferase
SynA1840_00093	COG1725	Transcriptional regulator
SynA1840_00094	COG0412	Dienelactone hydrolase
SynA1840_00095	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynA1840_00096	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynA1840_00097	COG1372	Participates in initiation and elongation during chromosome replication
SynA1840_00097	COG0187	DNA topoisomerase II activity
SynA1840_00099	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynA1840_00100	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynA1840_00101	COG0386	Belongs to the glutathione peroxidase family
SynA1840_00104	COG2239	Acts as a magnesium transporter
SynA1840_00105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1840_00109	COG0714	Associated with various cellular activities
SynA1840_00113	COG0802	atpase or kinase
SynA1840_00114	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynA1840_00115	COG0586	Pfam SNARE associated Golgi protein
SynA1840_00116	COG0629	single-stranded DNA binding
SynA1840_00121	COG0745	RESPONSE REGULATOR receiver
SynA1840_00122	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynA1840_00126	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynA1840_00127	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynA1840_00129	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynA1840_00130	COG2255	four-way junction helicase activity
SynA1840_00132	COG1473	amidohydrolase
SynA1840_00135	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynA1840_00136	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynA1840_00137	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynA1840_00138	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynA1840_00139	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1840_00140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynA1840_00141	COG0598	Magnesium transport protein CorA
SynA1840_00142	COG0662	Cupin 2, conserved barrel domain protein
SynA1840_00142	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynA1840_00143	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynA1840_00145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1840_00146	COG0571	ribonuclease III activity
SynA1840_00150	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SynA1840_00151	COG0058	SHG alpha-glucan phosphorylase activity
SynA1840_00153	COG0475	glutathione-regulated potassium exporter activity
SynA1840_00157	COG0277	FAD linked oxidase domain protein
SynA1840_00159	COG0247	lactate metabolic process
SynA1840_00164	COG0538	isocitrate dehydrogenase activity
SynA1840_00165	COG0463	Glycosyl transferase, family 2
SynA1840_00169	COG5398	heme oxygenase
SynA1840_00171	COG1132	(ABC) transporter
SynA1840_00172	COG0438	transferase activity, transferring glycosyl groups
SynA1840_00173	COG0438	transferase activity, transferring glycosyl groups
SynA1840_00174	COG0438	transferase activity, transferring glycosyl groups
SynA1840_00179	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynA1840_00181	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynA1840_00186	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynA1840_00188	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynA1840_00189	COG0517	IMP dehydrogenase activity
SynA1840_00189	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SynA1840_00190	COG0517	IMP dehydrogenase activity
SynA1840_00190	COG0617	tRNA 3'-terminal CCA addition
SynA1840_00190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SynA1840_00191	COG0709	Synthesizes selenophosphate from selenide and ATP
SynA1840_00192	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA1840_00194	COG2274	protein secretion by the type I secretion system
SynA1840_00196	COG0438	transferase activity, transferring glycosyl groups
SynA1840_00198	COG0124	histidyl-tRNA synthetase
SynA1840_00199	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynA1840_00200	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynA1840_00206	COG4447	cellulose binding
SynA1840_00207	COG1773	rubredoxin
SynA1840_00208	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1840_00209	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1840_00210	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1840_00211	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynA1840_00214	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1840_00214	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1840_00217	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SynA1840_00218	COG1132	(ABC) transporter
SynA1840_00219	COG0494	nUDIX hydrolase
SynA1840_00220	COG0415	Belongs to the DNA photolyase family
SynA1840_00226	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynA1840_00227	COG0131	Imidazoleglycerol-phosphate dehydratase
SynA1840_00228	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynA1840_00230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynA1840_00234	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynA1840_00235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynA1840_00237	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynA1840_00238	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynA1840_00241	COG1253	flavin adenine dinucleotide binding
SynA1840_00242	COG0673	inositol 2-dehydrogenase activity
SynA1840_00246	COG0343	queuine tRNA-ribosyltransferase activity
SynA1840_00248	COG2205	protein histidine kinase activity
SynA1840_00252	COG0138	bifunctional purine biosynthesis protein purh
SynA1840_00255	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynA1840_00256	COG0004	ammonium transporteR
SynA1840_00257	COG1489	DNA binding
SynA1840_00258	COG0728	peptidoglycan biosynthetic process
SynA1840_00263	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynA1840_00264	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA1840_00265	COG1546	Belongs to the CinA family
SynA1840_00265	COG1058	Belongs to the CinA family
SynA1840_00266	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynA1840_00267	COG0066	3-isopropylmalate dehydratase activity
SynA1840_00274	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynA1840_00275	COG0193	aminoacyl-tRNA hydrolase activity
SynA1840_00278	COG4372	Transposase
SynA1840_00279	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1840_00280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynA1840_00282	COG0717	Belongs to the dCTP deaminase family
SynA1840_00284	COG3118	belongs to the thioredoxin family
SynA1840_00285	COG0739	heme binding
SynA1840_00285	COG0741	lytic transglycosylase activity
SynA1840_00285	COG1196	nuclear chromosome segregation
SynA1840_00286	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynA1840_00287	COG2971	BadF BadG BcrA BcrD
SynA1840_00289	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynA1840_00293	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynA1840_00297	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA1840_00298	COG1402	creatininase
SynA1840_00300	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynA1840_00302	COG2094	Belongs to the DNA glycosylase MPG family
SynA1840_00303	COG0540	Belongs to the ATCase OTCase family
SynA1840_00310	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynA1840_00313	COG0529	Catalyzes the synthesis of activated sulfate
SynA1840_00313	COG2046	Belongs to the sulfate adenylyltransferase family
SynA1840_00314	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1840_00315	COG0800	Aldolase
SynA1840_00317	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynA1840_00324	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1840_00328	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynA1840_00329	COG0719	Fe-S assembly protein
SynA1840_00330	COG0396	ATPase activity
SynA1840_00331	COG0719	Fe-S assembly protein
SynA1840_00332	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynA1840_00334	COG0242	peptide deformylase activity
SynA1840_00338	COG0606	chelatase, subunit chli
SynA1840_00340	COG0537	adenosine 5'-monophosphoramidase activity
SynA1840_00341	COG4178	(ABC) transporter
SynA1840_00345	COG0515	serine threonine protein kinase
SynA1840_00348	COG0439	Biotin carboxylase
SynA1840_00350	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1840_00351	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1840_00354	COG1196	nuclear chromosome segregation
SynA1840_00359	COG0116	Belongs to the methyltransferase superfamily
SynA1840_00376	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA1840_00399	COG2089	acid synthase
SynA1840_00403	COG1083	cytidylyl-transferase
SynA1840_00405	COG3562	capsule polysaccharide
SynA1840_00407	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynA1840_00410	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynA1840_00427	COG0489	protein tyrosine kinase activity
SynA1840_00429	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA1840_00431	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynA1840_00432	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynA1840_00433	COG1132	(ABC) transporter
SynA1840_00435	COG1086	Polysaccharide biosynthesis protein
SynA1840_00439	COG2089	acid synthase
SynA1840_00443	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynA1840_00444	COG0463	Glycosyl transferase, family 2
SynA1840_00447	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynA1840_00452	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynA1840_00454	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SynA1840_00459	COG1215	transferase activity, transferring glycosyl groups
SynA1840_00469	COG1216	Glycosyl transferase, family 2
SynA1840_00470	COG0438	transferase activity, transferring glycosyl groups
SynA1840_00470	COG0297	glycogen (starch) synthase activity
SynA1840_00476	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA1840_00480	COG0347	Belongs to the P(II) protein family
SynA1840_00481	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynA1840_00490	COG1333	cytochrome c biogenesis protein
SynA1840_00494	COG0772	Belongs to the SEDS family
SynA1840_00508	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1840_00509	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1840_00511	COG0356	it plays a direct role in the translocation of protons across the membrane
SynA1840_00512	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynA1840_00513	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynA1840_00514	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynA1840_00515	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynA1840_00516	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynA1840_00517	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynA1840_00519	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA1840_00521	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynA1840_00522	COG3012	SEC-C Motif Domain Protein
SynA1840_00524	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynA1840_00524	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynA1840_00525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynA1840_00526	COG1160	GTP binding
SynA1840_00527	COG1253	flavin adenine dinucleotide binding
SynA1840_00528	COG0006	proline dipeptidase activity
SynA1840_00529	COG0387	Pfam Sodium calcium exchanger
SynA1840_00535	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynA1840_00536	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynA1840_00537	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynA1840_00538	COG0459	protein refolding
SynA1840_00543	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynA1840_00544	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynA1840_00547	COG0443	Heat shock 70 kDa protein
SynA1840_00554	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynA1840_00558	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynA1840_00559	COG2264	protein methyltransferase activity
SynA1840_00562	COG2010	Cytochrome c
SynA1840_00563	COG1234	tRNA 3'-trailer cleavage
SynA1840_00564	COG2385	sporulation resulting in formation of a cellular spore
SynA1840_00565	COG0363	glucosamine-6-phosphate deaminase activity
SynA1840_00568	COG0217	transcriptional regulatory protein
SynA1840_00569	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynA1840_00570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1840_00571	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynA1840_00572	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynA1840_00575	COG4251	negative regulation of phosphorylation
SynA1840_00576	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynA1840_00577	COG5002	protein histidine kinase activity
SynA1840_00578	COG0151	Belongs to the GarS family
SynA1840_00580	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynA1840_00582	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynA1840_00583	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynA1840_00584	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1840_00585	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1840_00586	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1840_00589	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynA1840_00596	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynA1840_00599	COG0284	orotidine-5'-phosphate decarboxylase activity
SynA1840_00606	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynA1840_00611	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynA1840_00612	COG2211	Major facilitator Superfamily
SynA1840_00616	COG0776	regulation of translation
SynA1840_00617	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA1840_00622	COG1053	succinate dehydrogenase
SynA1840_00629	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynA1840_00631	COG0195	Participates in both transcription termination and antitermination
SynA1840_00632	COG0779	Required for maturation of 30S ribosomal subunits
SynA1840_00635	COG0641	radical SAM
SynA1840_00638	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1840_00639	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynA1840_00640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynA1840_00641	COG0268	Binds directly to 16S ribosomal RNA
SynA1840_00642	COG0084	hydrolase, TatD family'
SynA1840_00643	COG0085	RNA polymerase activity
SynA1840_00644	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynA1840_00645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynA1840_00647	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynA1840_00658	COG0357	Ribosomal RNA small subunit methyltransferase G
SynA1840_00659	COG0484	heat shock protein binding
SynA1840_00660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynA1840_00663	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynA1840_00667	COG0385	Bile acid
SynA1840_00668	COG4581	dead DEAH box helicase
SynA1840_00669	COG0114	fumarate hydratase activity
SynA1840_00673	COG1216	Glycosyl transferase, family 2
SynA1840_00673	COG0438	transferase activity, transferring glycosyl groups
SynA1840_00678	COG1216	Glycosyl transferase, family 2
SynA1840_00678	COG0438	transferase activity, transferring glycosyl groups
SynA1840_00679	COG1088	dTDP-glucose 4,6-dehydratase activity
SynA1840_00685	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynA1840_00687	COG1215	transferase activity, transferring glycosyl groups
SynA1840_00688	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynA1840_00690	COG1160	GTP binding
SynA1840_00691	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynA1840_00693	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynA1840_00694	COG1799	cell septum assembly
SynA1840_00695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynA1840_00696	COG0438	transferase activity, transferring glycosyl groups
SynA1840_00698	COG1381	Involved in DNA repair and RecF pathway recombination
SynA1840_00699	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynA1840_00700	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynA1840_00701	COG0321	lipoyl(octanoyl) transferase activity
SynA1840_00702	COG1022	Amp-dependent synthetase and ligase
SynA1840_00704	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynA1840_00705	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynA1840_00706	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynA1840_00712	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1840_00713	COG0440	acetolactate synthase activity
SynA1840_00714	COG2267	carboxylic ester hydrolase activity
SynA1840_00719	COG2226	methyltransferase
SynA1840_00721	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynA1840_00722	COG0492	ferredoxin-NADP+ reductase activity
SynA1840_00733	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynA1840_00734	COG0733	neurotransmitter:sodium symporter activity
SynA1840_00736	COG0215	cysteine-tRNA ligase activity
SynA1840_00741	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynA1840_00741	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynA1840_00742	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynA1840_00743	COG0012	GTP binding
SynA1840_00746	COG0601	transmembrane transport
SynA1840_00749	COG0460	homoserine dehydrogenase
SynA1840_00750	COG2166	iron-sulfur cluster assembly
SynA1840_00752	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynA1840_00753	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynA1840_00754	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1840_00758	COG2010	Cytochrome c
SynA1840_00759	COG0742	ribosomal rna small subunit methyltransferase
SynA1840_00760	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynA1840_00761	COG3118	belongs to the thioredoxin family
SynA1840_00762	COG0516	GMP reductase activity
SynA1840_00764	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynA1840_00765	COG0644	oxidoreductase
SynA1840_00767	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynA1840_00768	COG0395	ABC-type sugar transport system, permease component
SynA1840_00773	COG0011	TIGRFAM Protein of
SynA1840_00776	COG0564	pseudouridine synthase activity
SynA1840_00778	COG1480	7TM receptor with intracellular HD hydrolase
SynA1840_00779	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynA1840_00782	COG0142	geranyltranstransferase activity
SynA1840_00784	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynA1840_00786	COG0406	alpha-ribazole phosphatase activity
SynA1840_00788	COG1254	Belongs to the acylphosphatase family
SynA1840_00789	COG1797	cobyrinic acid a,c-diamide synthase activity
SynA1840_00791	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynA1840_00795	COG2205	protein histidine kinase activity
SynA1840_00798	COG0308	aminopeptidase N
SynA1840_00801	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1840_00808	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynA1840_00810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1840_00816	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SynA1840_00818	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynA1840_00820	COG2197	response regulator
SynA1840_00821	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynA1840_00824	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynA1840_00827	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynA1840_00828	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1840_00829	COG0473	3-isopropylmalate dehydrogenase activity
SynA1840_00830	COG3954	Phosphoribulokinase
SynA1840_00832	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynA1840_00833	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynA1840_00835	COG0673	inositol 2-dehydrogenase activity
SynA1840_00836	COG0191	fructose-bisphosphate aldolase activity
SynA1840_00837	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynA1840_00838	COG0047	phosphoribosylformylglycinamidine synthase activity
SynA1840_00839	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynA1840_00841	COG0668	transmembrane transport
SynA1840_00843	COG0640	Transcriptional regulator
SynA1840_00844	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA1840_00853	COG5002	protein histidine kinase activity
SynA1840_00861	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynA1840_00864	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1840_00866	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynA1840_00867	COG1429	ligase activity, forming nitrogen-metal bonds
SynA1840_00875	COG4974	Belongs to the 'phage' integrase family
SynA1840_00883	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynA1840_00884	COG0149	triose-phosphate isomerase activity
SynA1840_00885	COG2501	S4 domain
SynA1840_00886	COG1132	(ABC) transporter
SynA1840_00889	COG1115	amino acid carrier protein
SynA1840_00891	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynA1840_00893	COG0799	negative regulation of ribosome biogenesis
SynA1840_00902	COG0659	secondary active sulfate transmembrane transporter activity
SynA1840_00903	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynA1840_00904	COG4597	amino acid ABC transporter
SynA1840_00905	COG0765	amino acid transport
SynA1840_00914	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynA1840_00921	COG0625	glutathione transferase activity
SynA1840_00928	COG1799	cell septum assembly
SynA1840_00932	COG0735	belongs to the Fur family
SynA1840_00935	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SynA1840_00945	COG0259	pyridoxamine-phosphate oxidase activity
SynA1840_00947	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynA1840_00955	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynA1840_00957	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynA1840_00962	COG0745	RESPONSE REGULATOR receiver
SynA1840_00963	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynA1840_00964	COG0271	Belongs to the BolA IbaG family
SynA1840_00967	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynA1840_00970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SynA1840_00971	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynA1840_00975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynA1840_00977	COG0513	Belongs to the DEAD box helicase family
SynA1840_00980	COG0724	RNA recognition motif
SynA1840_00982	COG1132	(ABC) transporter
SynA1840_00983	COG0589	response to stress
SynA1840_00983	COG0475	glutathione-regulated potassium exporter activity
SynA1840_00986	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynA1840_00987	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynA1840_00992	COG1054	Belongs to the UPF0176 family
SynA1840_00993	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynA1840_00994	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynA1840_00995	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynA1840_00996	COG0019	diaminopimelate decarboxylase activity
SynA1840_00997	COG0456	acetyltransferase
SynA1840_00998	COG0542	response to heat
SynA1840_00999	COG0371	Dehydrogenase
SynA1840_01000	COG0596	Alpha beta hydrolase
SynA1840_01002	COG0575	Belongs to the CDS family
SynA1840_01003	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynA1840_01004	COG1982	Orn Lys Arg decarboxylase major
SynA1840_01005	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1840_01007	COG0745	RESPONSE REGULATOR receiver
SynA1840_01008	COG5002	protein histidine kinase activity
SynA1840_01009	COG1187	pseudouridine synthase activity
SynA1840_01022	COG2274	protein secretion by the type I secretion system
SynA1840_01026	COG1640	4-alpha-glucanotransferase
SynA1840_01030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynA1840_01033	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA1840_01034	COG1121	(ABC) transporter
SynA1840_01039	COG0701	Predicted permease
SynA1840_01049	COG0681	Belongs to the peptidase S26 family
SynA1840_01050	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynA1840_01051	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynA1840_01053	COG0297	glycogen (starch) synthase activity
SynA1840_01055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynA1840_01056	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynA1840_01058	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynA1840_01059	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynA1840_01060	COG2045	Belongs to the ComB family
SynA1840_01062	COG0860	N-Acetylmuramoyl-L-alanine amidase
SynA1840_01063	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynA1840_01064	COG0142	geranyltranstransferase activity
SynA1840_01065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynA1840_01066	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynA1840_01068	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1840_01069	COG2176	DNA-directed DNA polymerase activity
SynA1840_01071	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA1840_01072	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1840_01076	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1840_01078	COG1132	(ABC) transporter
SynA1840_01080	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynA1840_01081	COG0505	Belongs to the CarA family
SynA1840_01083	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynA1840_01084	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1840_01086	COG0154	amidase activity
SynA1840_01087	COG0587	DNA-directed DNA polymerase activity
SynA1840_01089	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynA1840_01090	COG0632	four-way junction helicase activity
SynA1840_01094	COG0358	DNA primase activity
SynA1840_01095	COG0798	PFAM Bile acid sodium symporter
SynA1840_01100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynA1840_01103	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynA1840_01106	COG0792	nuclease activity
SynA1840_01107	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynA1840_01108	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynA1840_01111	COG0022	dehydrogenase e1 component
SynA1840_01111	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynA1840_01112	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynA1840_01113	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynA1840_01131	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynA1840_01132	COG0515	serine threonine protein kinase
SynA1840_01137	COG2226	methyltransferase
SynA1840_01138	COG0174	glutamine synthetase
SynA1840_01140	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynA1840_01144	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynA1840_01148	COG0612	Peptidase, M16
SynA1840_01154	COG1216	Glycosyl transferase, family 2
SynA1840_01155	COG0052	Belongs to the universal ribosomal protein uS2 family
SynA1840_01156	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynA1840_01158	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynA1840_01159	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynA1840_01160	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynA1840_01161	COG0751	glycine-tRNA ligase activity
SynA1840_01163	COG0644	oxidoreductase
SynA1840_01165	COG0826	peptidase U32
SynA1840_01166	COG1217	gtp-binding protein TYPA
SynA1840_01171	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynA1840_01173	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynA1840_01174	COG1494	fructose-1,6-bisphosphatase
SynA1840_01175	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynA1840_01176	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1840_01177	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynA1840_01178	COG0363	glucosamine-6-phosphate deaminase activity
SynA1840_01181	COG0129	dihydroxy-acid dehydratase activity
SynA1840_01183	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynA1840_01189	COG0300	oxidoreductase activity
SynA1840_01215	COG4974	Belongs to the 'phage' integrase family
SynA1840_01223	COG0582	viral genome integration into host DNA
SynA1840_01225	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SynA1840_01226	COG4106	trans-aconitate 2-methyltransferase activity
SynA1840_01227	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynA1840_01231	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynA1840_01236	COG1836	PFAM Integral membrane protein DUF92
SynA1840_01243	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynA1840_01244	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynA1840_01245	COG0436	Aminotransferase
SynA1840_01247	COG1573	uracil-dna glycosylase
SynA1840_01248	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynA1840_01249	COG0793	Belongs to the peptidase S41A family
SynA1840_01251	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynA1840_01256	COG0861	Integral membrane protein TerC family
SynA1840_01260	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynA1840_01262	COG0312	modulator of DNA gyrase
SynA1840_01263	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynA1840_01266	COG0163	prenyltransferase activity
SynA1840_01267	COG0557	exoribonuclease II activity
SynA1840_01269	COG2119	membrane
SynA1840_01272	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynA1840_01272	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynA1840_01276	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynA1840_01277	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1840_01278	COG1615	UPF0182 protein
SynA1840_01279	COG0450	alkyl hydroperoxide reductase
SynA1840_01281	COG0739	heme binding
SynA1840_01282	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynA1840_01288	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynA1840_01289	COG0445	tRNA wobble uridine modification
SynA1840_01290	COG0557	exoribonuclease II activity
SynA1840_01291	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynA1840_01292	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynA1840_01293	COG0072	phenylalanine-tRNA ligase activity
SynA1840_01293	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynA1840_01294	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynA1840_01306	COG0646	methionine synthase
SynA1840_01306	COG1410	methionine synthase
SynA1840_01307	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynA1840_01310	COG0613	PHP domain protein
SynA1840_01311	COG1981	membrane
SynA1840_01312	COG3046	protein related to deoxyribodipyrimidine photolyase
SynA1840_01314	COG0322	excinuclease ABC activity
SynA1840_01316	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynA1840_01318	COG2027	D-alanyl-D-alanine carboxypeptidase
SynA1840_01322	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynA1840_01324	COG0495	leucyl-tRNA aminoacylation
SynA1840_01325	COG0166	Belongs to the GPI family
SynA1840_01331	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynA1840_01332	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynA1840_01333	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynA1840_01333	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynA1840_01334	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1840_01335	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynA1840_01336	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynA1840_01338	COG0484	heat shock protein binding
SynA1840_01339	COG0443	Heat shock 70 kDa protein
SynA1840_01340	COG0573	inorganic phosphate transmembrane transporter activity
SynA1840_01341	COG0581	inorganic phosphate transmembrane transporter activity
SynA1840_01342	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynA1840_01344	COG0633	Ferredoxin
SynA1840_01345	COG0483	inositol monophosphate 1-phosphatase activity
SynA1840_01346	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynA1840_01348	COG0326	Molecular chaperone. Has ATPase activity
SynA1840_01349	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynA1840_01350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1840_01351	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynA1840_01352	COG1653	transport
SynA1840_01356	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA1840_01361	COG0644	oxidoreductase
SynA1840_01362	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynA1840_01363	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynA1840_01368	COG0469	pyruvate kinase activity
SynA1840_01369	COG1136	(ABC) transporter
SynA1840_01369	COG0577	efflux transmembrane transporter activity
SynA1840_01370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1840_01372	COG0740	serine-type endopeptidase activity
SynA1840_01377	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynA1840_01382	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynA1840_01383	COG1175	transmembrane transport
SynA1840_01384	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynA1840_01398	COG1793	dna ligase
SynA1840_01399	COG1201	RNA secondary structure unwinding
SynA1840_01401	COG2059	Chromate
SynA1840_01411	COG2226	methyltransferase
SynA1840_01419	COG1119	ATPase activity
SynA1840_01421	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA1840_01424	COG1121	(ABC) transporter
SynA1840_01425	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynA1840_01426	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynA1840_01427	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA1840_01453	COG0724	RNA recognition motif
SynA1840_01473	COG2197	response regulator
SynA1840_01478	COG2197	response regulator
SynA1840_01486	COG1487	ribonuclease activity
SynA1840_01499	COG0405	Gamma-glutamyltransferase
SynA1840_01524	COG2124	cytochrome p450
SynA1840_01531	COG0010	Belongs to the arginase family
SynA1840_01532	COG0375	protein maturation
SynA1840_01535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynA1840_01536	COG1116	anion transmembrane transporter activity
SynA1840_01537	COG4638	Rieske (2fe-2S)
SynA1840_01541	COG2144	transferase activity, transferring acyl groups
SynA1840_01546	COG2072	flavoprotein involved in K transport
SynA1840_01572	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynA1840_01580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1840_01608	COG0180	Tryptophanyl-tRNA synthetase
SynA1840_01611	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynA1840_01613	COG0837	glucose binding
SynA1840_01614	COG0083	homoserine kinase activity
SynA1840_01615	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1840_01616	COG0339	signal peptide processing
SynA1840_01619	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynA1840_01628	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynA1840_01629	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynA1840_01631	COG3794	PFAM blue (type 1) copper domain protein
SynA1840_01637	COG0542	response to heat
SynA1840_01639	COG0140	phosphoribosyl-ATP diphosphatase activity
SynA1840_01639	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynA1840_01644	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1840_01650	COG2010	Cytochrome c
SynA1840_01653	COG0159	tryptophan synthase activity
SynA1840_01658	COG0418	dihydroorotase activity
SynA1840_01659	COG0659	secondary active sulfate transmembrane transporter activity
SynA1840_01660	COG0530	calcium, potassium:sodium antiporter activity
SynA1840_01664	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynA1840_01667	COG0037	tRNA processing
SynA1840_01668	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynA1840_01669	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1840_01672	COG0456	acetyltransferase
SynA1840_01673	COG1132	(ABC) transporter
SynA1840_01674	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynA1840_01675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynA1840_01676	COG3842	ATPase activity
SynA1840_01677	COG0251	oxidation-reduction process
SynA1840_01733	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynA1840_01737	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynA1840_01738	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1840_01739	COG2135	peptidase activity
SynA1840_01743	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynA1840_01743	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynA1840_01752	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynA1840_01753	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynA1840_01754	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynA1840_01756	COG0196	riboflavin kinase activity
SynA1840_01758	COG0352	thiamine-phosphate diphosphorylase activity
SynA1840_01762	COG1691	(AIR) carboxylase
SynA1840_01764	COG0336	Belongs to the RNA methyltransferase TrmD family
SynA1840_01767	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynA1840_01769	COG0670	Belongs to the BI1 family
SynA1840_01770	COG1702	phosphate starvation-inducible protein PhoH
SynA1840_01771	COG0228	four-way junction DNA binding
SynA1840_01772	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynA1840_01774	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynA1840_01775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1840_01777	COG0482	sulfurtransferase activity
SynA1840_01778	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynA1840_01784	COG0134	indole-3-glycerol-phosphate synthase activity
SynA1840_01785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynA1840_01786	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1840_01789	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynA1840_01790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynA1840_01791	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynA1840_01792	COG0285	dihydrofolate synthase activity
SynA1840_01798	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA1840_01799	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynA1840_01802	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynA1840_01803	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynA1840_01804	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynA1840_01805	COG4956	integral membrane protein (PIN domain superfamily)
SynA1840_01806	COG0740	serine-type endopeptidase activity
SynA1840_01807	COG0740	serine-type endopeptidase activity
SynA1840_01808	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynA1840_01809	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynA1840_01818	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SynA1840_01827	COG0582	viral genome integration into host DNA
SynA1840_01843	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1840_01855	COG0752	glycyl-tRNA synthetase alpha subunit
SynA1840_01859	COG2226	methyltransferase
SynA1840_01860	COG0107	imidazoleglycerol-phosphate synthase activity
SynA1840_01862	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynA1840_01863	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynA1840_01864	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynA1840_01864	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynA1840_01865	COG3695	enzyme binding
SynA1840_01866	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1840_01871	COG0481	GTPase activity
SynA1840_01873	COG0579	oxidoreductase
SynA1840_01874	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynA1840_01878	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynA1840_01883	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SynA1840_01884	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynA1840_01895	COG0424	maF-like protein
SynA1840_01897	COG1492	cobalamin metabolic process
SynA1840_01903	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1840_01904	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynA1840_01905	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA1840_01910	COG4451	ribulose bisphosphate carboxylase, small
SynA1840_01911	COG1850	ribulose-bisphosphate carboxylase activity
SynA1840_01912	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA1840_01913	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynA1840_01914	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA1840_01916	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynA1840_01917	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynA1840_01918	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynA1840_01923	COG0730	response to heat
SynA1840_01924	COG0095	Lipoate-protein ligase
SynA1840_01925	COG0517	IMP dehydrogenase activity
SynA1840_01925	COG1994	Peptidase M50
SynA1840_01926	COG0135	phosphoribosylanthranilate isomerase activity
SynA1840_01927	COG0302	gtp cyclohydrolase
SynA1840_01928	COG4221	oxidoreductase activity
SynA1840_01929	COG0825	malonyl-CoA metabolic process
SynA1840_01930	COG5322	oxidoreductase activity
SynA1840_01931	COG3396	Phenylacetate-CoA oxygenase
SynA1840_01933	COG0539	negative regulation of cytoplasmic translation
SynA1840_01935	COG1496	oxidoreductase activity
SynA1840_01936	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynA1840_01940	COG0028	Belongs to the TPP enzyme family
SynA1840_01941	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1840_01943	COG2226	methyltransferase
SynA1840_01946	COG0528	UMP kinase activity
SynA1840_01947	COG0233	cytoplasmic translational termination
SynA1840_01955	COG0415	Belongs to the DNA photolyase family
SynA1840_01957	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynA1840_01958	COG0768	penicillin binding
SynA1840_01961	COG0588	phosphoglycerate mutase activity
SynA1840_01963	COG0681	Belongs to the peptidase S26 family
SynA1840_01967	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynA1840_01971	COG0442	prolyl-tRNA aminoacylation
SynA1840_01973	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynA1840_01974	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynA1840_01976	COG0629	single-stranded DNA binding
SynA1840_01979	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynA1840_01981	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynA1840_01983	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1840_01985	COG0181	hydroxymethylbilane synthase activity
SynA1840_01988	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynA1840_01994	COG0432	Pfam Uncharacterised protein family UPF0047
SynA1840_01995	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynA1840_01996	COG0523	cobalamin synthesis protein
SynA1840_01998	COG1840	ABC-type Fe3 transport system, periplasmic component
SynA1840_02003	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynA1840_02004	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1840_02008	COG0708	Exodeoxyribonuclease III
SynA1840_02009	COG0277	FAD linked oxidase domain protein
SynA1840_02010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynA1840_02014	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SynA1840_02017	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA1840_02018	COG1666	GTP binding
SynA1840_02021	COG0857	belongs to the CobB CobQ family
SynA1840_02023	COG3000	fatty acid hydroxylase
SynA1840_02023	COG0300	oxidoreductase activity
SynA1840_02024	COG0024	Methionine aminopeptidase
SynA1840_02026	COG0335	large ribosomal subunit rRNA binding
SynA1840_02030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA1840_02033	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SynA1840_02035	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1840_02036	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynA1840_02039	COG0194	GDP metabolic process
SynA1840_02040	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynA1840_02041	COG0805	protein transport
SynA1840_02043	COG0723	plastoquinol--plastocyanin reductase activity
SynA1840_02044	COG0739	heme binding
SynA1840_02045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynA1840_02046	COG2875	Belongs to the precorrin methyltransferase family
SynA1840_02049	COG0248	Ppx GppA phosphatase
SynA1840_02050	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynA1840_02051	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynA1840_02052	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynA1840_02055	COG1028	Short-chain dehydrogenase reductase Sdr
SynA1840_02057	COG0459	protein refolding
SynA1840_02058	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynA1840_02062	COG0109	protoheme IX farnesyltransferase activity
SynA1840_02063	COG1612	heme a metabolic process
SynA1840_02065	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynA1840_02067	COG1845	cytochrome c oxidase, subunit III
SynA1840_02073	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynA1840_02076	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynA1840_02078	COG1007	ATP synthesis coupled electron transport
SynA1840_02079	COG1136	(ABC) transporter
SynA1840_02079	COG0577	efflux transmembrane transporter activity
SynA1840_02081	COG2205	protein histidine kinase activity
SynA1840_02083	COG0745	RESPONSE REGULATOR receiver
SynA1840_02084	COG0739	heme binding
SynA1840_02086	COG0436	Aminotransferase
SynA1840_02087	COG3118	belongs to the thioredoxin family
SynA1840_02088	COG1842	Phage shock protein A
SynA1840_02091	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynA1840_02093	COG0697	spore germination
SynA1840_02094	COG0616	signal peptide processing
SynA1840_02097	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynA1840_02098	COG0594	ribonuclease P activity
SynA1840_02100	COG0706	membrane insertase activity
SynA1840_02102	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1840_02104	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynA1840_02105	COG0750	zinc metalloprotease
SynA1840_02106	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynA1840_02107	COG1185	polyribonucleotide nucleotidyltransferase activity
SynA1840_02109	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynA1840_02130	COG0322	excinuclease ABC activity
SynA1840_02143	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SynA1840_02144	COG2226	methyltransferase
SynA1840_02147	COG4176	ABC-type proline glycine betaine transport system permease component
SynA1840_02148	COG2113	Glycine betaine
SynA1840_02154	COG2988	succinylglutamate desuccinylase activity
SynA1840_02155	COG0435	Glutathione S-transferase
SynA1840_02157	COG0488	(ABC) transporter
SynA1840_02160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynA1840_02161	COG3842	ATPase activity
SynA1840_02163	COG1193	negative regulation of DNA recombination
SynA1840_02165	COG0113	porphobilinogen synthase activity
SynA1840_02166	COG0484	heat shock protein binding
SynA1840_02167	COG4243	Vitamin k epoxide reductase
SynA1840_02168	COG0659	secondary active sulfate transmembrane transporter activity
SynA1840_02171	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynA1840_02184	COG4106	trans-aconitate 2-methyltransferase activity
SynA1840_02190	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SynA1840_02197	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynA1840_02198	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynA1840_02200	COG1012	belongs to the aldehyde dehydrogenase family
SynA1840_02201	COG0741	lytic transglycosylase activity
SynA1840_02201	COG1388	LysM domain
SynA1840_02205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynA1840_02206	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynA1840_02207	COG0235	Class ii aldolase
SynA1840_02208	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynA1840_02215	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynA1840_02216	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynA1840_02217	COG0793	Belongs to the peptidase S41A family
SynA1840_02218	COG1078	dGTPase activity
SynA1840_02219	COG0850	regulation of cytokinetic process
SynA1840_02220	COG2894	cell division
SynA1840_02221	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynA1840_02225	COG0009	L-threonylcarbamoyladenylate synthase
SynA1840_02226	COG2890	protein-(glutamine-N5) methyltransferase activity
SynA1840_02227	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynA1840_02227	COG0758	DNA mediated transformation
SynA1840_02233	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynA1840_02234	COG0539	negative regulation of cytoplasmic translation
SynA1840_02235	COG0546	phosphoglycolate phosphatase activity
SynA1840_02236	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynA1840_02237	COG1070	Carbohydrate kinase
SynA1840_02242	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynA1840_02249	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1840_02286	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynA1840_02287	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynA1840_02287	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynA1840_02288	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynA1840_02289	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynA1840_02291	COG4989	oxidoreductase activity
SynA1840_02297	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SynA1840_02301	COG0408	coproporphyrinogen oxidase activity
SynA1840_02303	COG0489	protein tyrosine kinase activity
SynA1840_02304	COG0772	Belongs to the SEDS family
SynA1840_02307	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynA1840_02309	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynA1840_02312	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynA1840_02313	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynA1840_02314	COG1606	tRNA processing
SynA1840_02315	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynA1840_02319	COG3001	Fructosamine kinase
SynA1840_02320	COG1233	COG1233 Phytoene dehydrogenase and related
SynA1840_02325	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynA1840_02328	COG3854	ATPases associated with a variety of cellular activities
SynA1840_02331	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynA1840_02332	COG0088	Forms part of the polypeptide exit tunnel
SynA1840_02333	COG0089	rRNA binding
SynA1840_02334	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynA1840_02335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynA1840_02336	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynA1840_02337	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynA1840_02338	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynA1840_02339	COG0255	Belongs to the universal ribosomal protein uL29 family
SynA1840_02340	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynA1840_02341	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynA1840_02342	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynA1840_02343	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynA1840_02344	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynA1840_02345	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynA1840_02346	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynA1840_02347	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynA1840_02348	COG0200	Binds to the 23S rRNA
SynA1840_02349	COG0201	protein transport
SynA1840_02350	COG0563	adenylate kinase activity
SynA1840_02351	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynA1840_02352	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynA1840_02353	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynA1840_02354	COG0202	RNA polymerase activity
SynA1840_02355	COG0203	ribosomal protein L17
SynA1840_02356	COG0101	tRNA pseudouridine synthase activity
SynA1840_02357	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynA1840_02358	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynA1840_02359	COG0254	rRNA binding
SynA1840_02360	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynA1840_02362	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynA1840_02366	COG0463	Glycosyl transferase, family 2
SynA1840_02375	COG2885	chlorophyll binding
SynA1840_02376	COG2885	chlorophyll binding
SynA1840_02384	COG3659	wide pore channel activity
SynA1840_02386	COG3128	pkhd-type hydroxylase
SynA1840_02387	COG1840	ABC-type Fe3 transport system, periplasmic component
SynA1840_02395	COG3659	wide pore channel activity
SynA1840_02399	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynA1840_02401	COG0070	glutamate synthase
SynA1840_02401	COG0067	glutamate synthase
SynA1840_02401	COG0069	glutamate synthase activity
SynA1840_02405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynA1840_02406	COG0049	tRNA binding
SynA1840_02407	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynA1840_02408	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynA1840_02409	COG0051	transcription antitermination factor activity, RNA binding
SynA1840_02410	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynA1840_02411	COG2226	methyltransferase
SynA1840_02412	COG1605	Chorismate mutase
SynA1840_02412	COG0077	Prephenate dehydratase
SynA1840_02414	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynA1840_02415	COG1530	ribonuclease E activity
SynA1840_02417	COG0436	Aminotransferase
SynA1840_02418	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynA1840_02425	COG0033	Phosphoglucomutase
SynA1840_02427	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynA1840_02429	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SynA1840_02433	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1840_02434	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynA1840_02435	COG0175	sulfate reduction
SynA1840_02436	COG1252	NADH dehydrogenase
SynA1840_02437	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynA1840_02438	COG3273	potassium ion transport
SynA1840_02438	COG0471	metal ion transport
SynA1840_02439	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynA1840_02440	COG0569	domain protein
SynA1840_02441	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynA1840_02446	COG0488	(ABC) transporter
SynA1840_02448	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1840_02452	COG1643	Atp-dependent helicase
SynA1840_02453	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1840_02455	COG1570	exodeoxyribonuclease VII activity
SynA1840_02456	COG1722	exodeoxyribonuclease VII activity
SynA1840_02468	COG1968	undecaprenyl-diphosphatase activity
SynA1840_02470	COG1555	photosystem II stabilization
SynA1840_02471	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynA1840_02472	COG4243	Vitamin k epoxide reductase
SynA1840_02473	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA1840_02475	COG1032	radical SAM domain protein
SynA1840_02481	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynA1840_02486	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynA1840_02487	COG1472	Belongs to the glycosyl hydrolase 3 family
SynA1840_02488	COG0463	Glycosyl transferase, family 2
SynA1840_02488	COG0457	Tetratricopeptide repeat
SynA1840_02489	COG1587	Uroporphyrinogen-III synthase
SynA1840_02492	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynA1840_02493	COG0316	Belongs to the HesB IscA family
SynA1840_02497	COG1090	epimerase
SynA1840_02501	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynA1840_02502	COG3659	wide pore channel activity
SynA1840_02503	COG3659	wide pore channel activity
SynA1840_02505	COG3659	wide pore channel activity
SynA1840_02506	COG3659	wide pore channel activity
SynA1840_02513	COG1122	ATPase activity
SynA1840_02517	COG0745	RESPONSE REGULATOR receiver
SynA1840_02519	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynA1840_02520	COG2217	Heavy metal translocating P-type atpase
SynA1840_02521	COG3063	Type IV pilus biogenesis stability protein PilW
SynA1840_02522	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynA1840_02524	COG0416	fatty acid biosynthetic process
SynA1840_02525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynA1840_02526	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynA1840_02529	COG1214	PFAM Peptidase M22, glycoprotease
SynA1840_02531	COG0617	tRNA 3'-terminal CCA addition
SynA1840_02532	COG0724	RNA recognition motif
SynA1840_02533	COG1562	ergosterol biosynthetic process
SynA1840_02534	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynA1840_02534	COG0493	'glutamate synthase
SynA1840_02537	COG0583	DNA-binding transcription factor activity
SynA1840_02539	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynA1840_02540	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1840_02543	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynA1840_02545	COG2197	response regulator
SynA1840_02548	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynA1840_02549	COG0713	ATP synthesis coupled electron transport
SynA1840_02550	COG0839	Belongs to the complex I subunit 6 family
SynA1840_02551	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1840_02552	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynA1840_02553	COG0372	Belongs to the citrate synthase family
SynA1840_02554	COG2062	phosphohistidine phosphatase, SixA
SynA1840_02557	COG1420	regulation of RNA biosynthetic process
SynA1840_02558	COG0133	tryptophan synthase activity
SynA1840_02559	COG0023	Translation Initiation Factor
SynA1840_02560	COG0529	Catalyzes the synthesis of activated sulfate
SynA1840_02561	COG0628	permease
SynA1840_02562	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynA1840_02563	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SynA1840_02564	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1840_02565	COG0564	pseudouridine synthase activity
SynA1840_02566	COG0745	RESPONSE REGULATOR receiver
SynA1840_02568	COG1104	cysteine desulfurase activity
SynA1840_02578	COG0275	rRNA processing
SynA1840_02579	COG0649	NAD binding
SynA1840_02582	COG0824	Thioesterase
SynA1840_02592	COG0318	PFAM AMP-dependent synthetase and ligase
SynA1840_02594	COG1575	Belongs to the MenA family. Type 1 subfamily
SynA1840_02596	COG0189	ligase activity
SynA1840_02597	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynA1840_02598	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynA1840_02600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynA1840_02601	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynA1840_02602	COG0512	Glutamine amidotransferase of anthranilate synthase
SynA1840_02604	COG0252	asparaginase activity
SynA1840_02605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynA1840_02606	COG0018	arginyl-trna synthetase
SynA1840_02607	COG0157	Belongs to the NadC ModD family
SynA1840_02609	COG1475	DNA binding
SynA1840_02611	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynA1840_02613	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynA1840_02614	COG4172	Belongs to the ABC transporter superfamily
SynA1840_02615	COG0564	pseudouridine synthase activity
SynA1840_02617	COG0589	response to stress
SynA1840_02618	COG0126	phosphoglycerate kinase activity
SynA1840_02622	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynA1840_02623	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynA1840_02632	COG0167	dihydroorotate dehydrogenase activity
SynA1840_02633	COG0328	RNA-DNA hybrid ribonuclease activity
SynA1840_02636	COG0222	ribosome binding
SynA1840_02637	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynA1840_02639	COG0081	regulation of translation
SynA1840_02640	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynA1840_02641	COG0250	Participates in transcription elongation, termination and antitermination
SynA1840_02642	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynA1840_02643	COG0542	response to heat
SynA1840_02644	COG0346	lactoylglutathione lyase activity
SynA1840_02645	COG0148	phosphopyruvate hydratase activity
SynA1840_02646	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1840_02651	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynA1840_02652	COG0237	dephospho-CoA kinase activity
SynA1840_02654	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA1840_02655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynA1840_02655	COG2022	thiamine diphosphate biosynthetic process
SynA1840_02656	COG0105	UTP biosynthetic process
SynA1840_02657	COG1166	arginine decarboxylase activity
SynA1840_02658	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynA1840_02660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynA1840_02663	COG0071	Belongs to the small heat shock protein (HSP20) family
SynA1840_02665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynA1840_02665	COG0426	domain, Protein
SynA1840_02666	COG0426	domain, Protein
SynA1840_02666	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynA1840_02668	COG1733	regulation of RNA biosynthetic process
SynA1840_02670	COG1741	Belongs to the pirin family
SynA1840_02674	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynA1840_02674	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynA1840_02675	COG0509	glycine decarboxylation via glycine cleavage system
SynA1840_02676	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynA1840_02678	COG0359	binds to the 23S rRNA
SynA1840_02679	COG1372	Participates in initiation and elongation during chromosome replication
SynA1840_02679	COG0305	Participates in initiation and elongation during chromosome replication
SynA1840_02679	COG0305	Participates in initiation and elongation during chromosome replication
SynA1840_02679	COG1372	Participates in initiation and elongation during chromosome replication
SynA1840_02682	COG0445	tRNA wobble uridine modification
SynA1840_02690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynA1840_02694	COG0398	Pfam SNARE associated Golgi protein
SynA1840_02698	COG0525	valine-tRNA ligase activity
SynA1840_02702	COG4221	oxidoreductase activity
SynA1840_02727	COG3956	TIGRFAM MazG family protein
SynA1840_02729	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynA1840_02730	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynA1840_02731	COG0010	Belongs to the arginase family
SynA1840_02734	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynA1840_02735	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynA1840_02737	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1840_02738	COG0504	CTP synthase activity
SynA1840_02739	COG0602	queuosine metabolic process
SynA1840_02740	COG2084	Dehydrogenase
SynA1840_02741	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynA1840_02745	COG0366	Alpha amylase catalytic
SynA1840_02746	COG0463	Glycosyl transferase, family 2
SynA1840_02754	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynA1840_02755	COG0830	nickel cation binding
SynA1840_02756	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynA1840_02757	COG0829	nickel cation binding
SynA1840_02758	COG0831	urea catabolic process
SynA1840_02759	COG0832	Belongs to the urease beta subunit family
SynA1840_02760	COG0804	urea catabolic process
SynA1840_02765	COG0367	asparagine synthase
SynA1840_02766	COG0540	Belongs to the ATCase OTCase family
SynA1840_02770	COG2308	Evidence 4 Homologs of previously reported genes of
SynA1840_02774	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynA1840_02775	COG0746	molybdenum cofactor guanylyltransferase activity
SynA1840_02777	COG2223	nitrite transmembrane transporter activity
SynA1840_02778	COG0243	molybdopterin cofactor binding
SynA1840_02782	COG0315	cyclic pyranopterin monophosphate synthase activity
SynA1840_02786	COG0314	molybdopterin synthase activity
SynA1840_02788	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynA1840_02789	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynA1840_02791	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynA1840_02793	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA1840_02794	COG1121	(ABC) transporter
SynA1840_02795	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynA1840_02797	COG0523	cobalamin synthesis protein
SynA1840_02801	COG1116	anion transmembrane transporter activity
SynA1840_02802	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynA1840_02803	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SynA1840_02803	COG1116	anion transmembrane transporter activity
SynA1840_02804	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynA1840_02806	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynA1840_02808	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynA1840_02811	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynA1840_02812	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1840_02813	COG0170	dolichyl monophosphate biosynthetic process
SynA1840_02815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynA1840_02816	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynA1840_02819	COG0788	formyltetrahydrofolate deformylase activity
SynA1840_02822	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA1840_02824	COG0443	Heat shock 70 kDa protein
SynA1840_02825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynA1840_02827	COG0360	Binds together with S18 to 16S ribosomal RNA
SynA1840_02829	COG0137	argininosuccinate synthase activity
SynA1840_02832	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA1840_02835	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynA1840_02836	COG0438	transferase activity, transferring glycosyl groups
SynA1840_02839	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynA1840_02840	COG0497	DNA recombination
SynA1840_02841	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1840_02843	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine