locus-tag	class	description
SynA18461_00001	COG0592	DNA-directed DNA polymerase activity
SynA18461_00003	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynA18461_00004	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SynA18461_00005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynA18461_00007	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynA18461_00010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynA18461_00011	COG0552	protein localization to endoplasmic reticulum
SynA18461_00012	COG2208	phosphoserine phosphatase activity
SynA18461_00013	COG0165	Argininosuccinate lyase
SynA18461_00014	COG0724	RNA recognition motif
SynA18461_00015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynA18461_00016	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA18461_00017	COG2081	HI0933 family
SynA18461_00018	COG1459	type II secretion system
SynA18461_00020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynA18461_00021	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynA18461_00022	COG0484	heat shock protein binding
SynA18461_00024	COG1162	GTPase activity
SynA18461_00025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynA18461_00026	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynA18461_00027	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynA18461_00029	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA18461_00030	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynA18461_00031	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA18461_00032	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynA18461_00033	COG0511	ligase activity, forming carbon-carbon bonds
SynA18461_00034	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynA18461_00049	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynA18461_00050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynA18461_00050	COG0519	Catalyzes the synthesis of GMP from XMP
SynA18461_00053	COG0768	penicillin binding
SynA18461_00054	COG0438	transferase activity, transferring glycosyl groups
SynA18461_00057	COG2022	thiamine diphosphate biosynthetic process
SynA18461_00060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynA18461_00061	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynA18461_00062	COG2385	sporulation resulting in formation of a cellular spore
SynA18461_00063	COG1215	transferase activity, transferring glycosyl groups
SynA18461_00064	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynA18461_00066	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynA18461_00067	COG0740	serine-type endopeptidase activity
SynA18461_00068	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynA18461_00069	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynA18461_00070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynA18461_00071	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynA18461_00077	COG2082	Precorrin-8x methylmutase
SynA18461_00078	COG0037	tRNA processing
SynA18461_00080	COG0556	nucleotide-excision repair
SynA18461_00081	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynA18461_00085	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynA18461_00090	COG0653	protein targeting
SynA18461_00094	COG1045	serine acetyltransferase
SynA18461_00095	COG1725	Transcriptional regulator
SynA18461_00096	COG0412	Dienelactone hydrolase
SynA18461_00097	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynA18461_00098	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynA18461_00099	COG1372	Participates in initiation and elongation during chromosome replication
SynA18461_00099	COG0187	DNA topoisomerase II activity
SynA18461_00101	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynA18461_00102	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynA18461_00103	COG0386	Belongs to the glutathione peroxidase family
SynA18461_00106	COG2239	Acts as a magnesium transporter
SynA18461_00107	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA18461_00111	COG0714	Associated with various cellular activities
SynA18461_00117	COG2015	COG2015, Alkyl sulfatase and related hydrolases
SynA18461_00122	COG0802	atpase or kinase
SynA18461_00123	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynA18461_00124	COG0586	Pfam SNARE associated Golgi protein
SynA18461_00125	COG0629	single-stranded DNA binding
SynA18461_00130	COG0745	RESPONSE REGULATOR receiver
SynA18461_00131	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynA18461_00135	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynA18461_00136	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynA18461_00138	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynA18461_00139	COG2255	four-way junction helicase activity
SynA18461_00141	COG1473	amidohydrolase
SynA18461_00144	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynA18461_00145	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynA18461_00146	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynA18461_00147	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynA18461_00148	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA18461_00149	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynA18461_00150	COG0598	Magnesium transport protein CorA
SynA18461_00152	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynA18461_00154	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA18461_00155	COG0571	ribonuclease III activity
SynA18461_00159	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SynA18461_00160	COG0058	SHG alpha-glucan phosphorylase activity
SynA18461_00162	COG0475	glutathione-regulated potassium exporter activity
SynA18461_00166	COG0277	FAD linked oxidase domain protein
SynA18461_00168	COG0247	lactate metabolic process
SynA18461_00172	COG0538	isocitrate dehydrogenase activity
SynA18461_00173	COG0463	Glycosyl transferase, family 2
SynA18461_00175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SynA18461_00177	COG5398	heme oxygenase
SynA18461_00179	COG1132	(ABC) transporter
SynA18461_00180	COG0438	transferase activity, transferring glycosyl groups
SynA18461_00186	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynA18461_00203	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynA18461_00205	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynA18461_00206	COG0517	IMP dehydrogenase activity
SynA18461_00206	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SynA18461_00207	COG0517	IMP dehydrogenase activity
SynA18461_00207	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SynA18461_00207	COG0617	tRNA 3'-terminal CCA addition
SynA18461_00209	COG0709	Synthesizes selenophosphate from selenide and ATP
SynA18461_00210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA18461_00212	COG2274	protein secretion by the type I secretion system
SynA18461_00214	COG0438	transferase activity, transferring glycosyl groups
SynA18461_00216	COG0124	histidyl-tRNA synthetase
SynA18461_00217	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynA18461_00218	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynA18461_00224	COG4447	cellulose binding
SynA18461_00225	COG1773	rubredoxin
SynA18461_00226	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA18461_00227	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA18461_00228	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA18461_00229	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynA18461_00232	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA18461_00232	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA18461_00235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SynA18461_00236	COG1132	(ABC) transporter
SynA18461_00237	COG0494	nUDIX hydrolase
SynA18461_00238	COG0415	Belongs to the DNA photolyase family
SynA18461_00244	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynA18461_00245	COG0131	Imidazoleglycerol-phosphate dehydratase
SynA18461_00246	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynA18461_00248	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynA18461_00252	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynA18461_00253	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynA18461_00255	COG0354	folic acid binding
SynA18461_00256	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynA18461_00259	COG1253	flavin adenine dinucleotide binding
SynA18461_00260	COG0673	inositol 2-dehydrogenase activity
SynA18461_00264	COG0343	queuine tRNA-ribosyltransferase activity
SynA18461_00266	COG2205	protein histidine kinase activity
SynA18461_00270	COG0138	bifunctional purine biosynthesis protein purh
SynA18461_00273	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynA18461_00274	COG0004	ammonium transporteR
SynA18461_00275	COG1489	DNA binding
SynA18461_00276	COG0728	peptidoglycan biosynthetic process
SynA18461_00281	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynA18461_00282	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA18461_00283	COG1546	Belongs to the CinA family
SynA18461_00283	COG1058	Belongs to the CinA family
SynA18461_00284	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynA18461_00285	COG0066	3-isopropylmalate dehydratase activity
SynA18461_00292	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynA18461_00293	COG0193	aminoacyl-tRNA hydrolase activity
SynA18461_00296	COG4372	Transposase
SynA18461_00297	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA18461_00298	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynA18461_00300	COG0717	Belongs to the dCTP deaminase family
SynA18461_00302	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynA18461_00303	COG0739	heme binding
SynA18461_00303	COG1196	nuclear chromosome segregation
SynA18461_00303	COG0741	lytic transglycosylase activity
SynA18461_00304	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynA18461_00305	COG2971	BadF BadG BcrA BcrD
SynA18461_00307	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynA18461_00311	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynA18461_00315	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA18461_00316	COG1402	creatininase
SynA18461_00318	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynA18461_00319	COG0540	Belongs to the ATCase OTCase family
SynA18461_00326	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynA18461_00329	COG0529	Catalyzes the synthesis of activated sulfate
SynA18461_00329	COG2046	Belongs to the sulfate adenylyltransferase family
SynA18461_00330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA18461_00331	COG0800	Aldolase
SynA18461_00333	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynA18461_00338	COG4974	Belongs to the 'phage' integrase family
SynA18461_00348	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynA18461_00353	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA18461_00357	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynA18461_00358	COG0719	Fe-S assembly protein
SynA18461_00359	COG0396	ATPase activity
SynA18461_00360	COG0719	Fe-S assembly protein
SynA18461_00361	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynA18461_00363	COG0242	peptide deformylase activity
SynA18461_00367	COG0606	chelatase, subunit chli
SynA18461_00368	COG0537	adenosine 5'-monophosphoramidase activity
SynA18461_00369	COG4178	(ABC) transporter
SynA18461_00373	COG0515	serine threonine protein kinase
SynA18461_00376	COG0439	Biotin carboxylase
SynA18461_00378	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA18461_00388	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA18461_00391	COG1196	nuclear chromosome segregation
SynA18461_00396	COG0116	Belongs to the methyltransferase superfamily
SynA18461_00441	COG2089	acid synthase
SynA18461_00445	COG1083	cytidylyl-transferase
SynA18461_00447	COG3562	capsule polysaccharide
SynA18461_00449	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynA18461_00452	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynA18461_00459	COG2274	protein secretion by the type I secretion system
SynA18461_00463	COG0438	transferase activity, transferring glycosyl groups
SynA18461_00468	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA18461_00471	COG1132	(ABC) transporter
SynA18461_00472	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SynA18461_00474	COG2089	acid synthase
SynA18461_00475	COG1083	cytidylyl-transferase
SynA18461_00475	COG2755	lipolytic protein G-D-S-L family
SynA18461_00476	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SynA18461_00478	COG2226	methyltransferase
SynA18461_00480	COG1028	Short-chain dehydrogenase reductase Sdr
SynA18461_00481	COG1028	Short-chain dehydrogenase reductase Sdr
SynA18461_00485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA18461_00488	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynA18461_00492	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynA18461_00499	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA18461_00501	COG1086	Polysaccharide biosynthesis protein
SynA18461_00507	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynA18461_00517	COG1333	cytochrome c biogenesis protein
SynA18461_00521	COG0772	Belongs to the SEDS family
SynA18461_00530	COG2161	toxin-antitoxin pair type II binding
SynA18461_00535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA18461_00536	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA18461_00538	COG0356	it plays a direct role in the translocation of protons across the membrane
SynA18461_00539	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynA18461_00540	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynA18461_00541	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynA18461_00542	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynA18461_00543	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynA18461_00544	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynA18461_00546	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA18461_00548	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynA18461_00549	COG3012	SEC-C Motif Domain Protein
SynA18461_00551	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynA18461_00551	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynA18461_00552	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynA18461_00553	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynA18461_00554	COG1253	flavin adenine dinucleotide binding
SynA18461_00555	COG0006	proline dipeptidase activity
SynA18461_00556	COG0387	Pfam Sodium calcium exchanger
SynA18461_00560	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynA18461_00561	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynA18461_00562	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynA18461_00563	COG0459	protein refolding
SynA18461_00569	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynA18461_00570	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynA18461_00573	COG0443	Heat shock 70 kDa protein
SynA18461_00580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynA18461_00585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynA18461_00586	COG2264	protein methyltransferase activity
SynA18461_00589	COG2010	Cytochrome c
SynA18461_00590	COG1234	tRNA 3'-trailer cleavage
SynA18461_00591	COG2385	sporulation resulting in formation of a cellular spore
SynA18461_00592	COG0363	glucosamine-6-phosphate deaminase activity
SynA18461_00595	COG0217	transcriptional regulatory protein
SynA18461_00596	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynA18461_00598	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynA18461_00599	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynA18461_00602	COG4251	negative regulation of phosphorylation
SynA18461_00603	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynA18461_00604	COG5002	protein histidine kinase activity
SynA18461_00605	COG0151	Belongs to the GarS family
SynA18461_00607	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynA18461_00609	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynA18461_00610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynA18461_00611	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA18461_00612	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA18461_00613	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA18461_00616	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynA18461_00621	COG2197	response regulator
SynA18461_00624	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynA18461_00627	COG0284	orotidine-5'-phosphate decarboxylase activity
SynA18461_00634	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynA18461_00639	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynA18461_00640	COG2211	Major facilitator Superfamily
SynA18461_00644	COG0776	regulation of translation
SynA18461_00645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA18461_00650	COG1053	succinate dehydrogenase
SynA18461_00658	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynA18461_00660	COG0195	Participates in both transcription termination and antitermination
SynA18461_00661	COG0779	Required for maturation of 30S ribosomal subunits
SynA18461_00664	COG0641	radical SAM
SynA18461_00668	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA18461_00669	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynA18461_00670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynA18461_00671	COG0268	Binds directly to 16S ribosomal RNA
SynA18461_00672	COG0084	hydrolase, TatD family'
SynA18461_00673	COG0085	RNA polymerase activity
SynA18461_00674	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynA18461_00675	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynA18461_00677	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynA18461_00690	COG0357	Ribosomal RNA small subunit methyltransferase G
SynA18461_00691	COG0484	heat shock protein binding
SynA18461_00692	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynA18461_00695	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynA18461_00699	COG0385	Bile acid
SynA18461_00700	COG4581	dead DEAH box helicase
SynA18461_00701	COG0114	fumarate hydratase activity
SynA18461_00705	COG0438	transferase activity, transferring glycosyl groups
SynA18461_00705	COG1216	Glycosyl transferase, family 2
SynA18461_00709	COG0438	transferase activity, transferring glycosyl groups
SynA18461_00709	COG1216	Glycosyl transferase, family 2
SynA18461_00710	COG1088	dTDP-glucose 4,6-dehydratase activity
SynA18461_00716	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynA18461_00718	COG1215	transferase activity, transferring glycosyl groups
SynA18461_00719	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynA18461_00721	COG1160	GTP binding
SynA18461_00722	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynA18461_00724	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynA18461_00725	COG1799	cell septum assembly
SynA18461_00726	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynA18461_00727	COG0438	transferase activity, transferring glycosyl groups
SynA18461_00729	COG1381	Involved in DNA repair and RecF pathway recombination
SynA18461_00730	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynA18461_00731	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynA18461_00732	COG0321	lipoyl(octanoyl) transferase activity
SynA18461_00733	COG1022	Amp-dependent synthetase and ligase
SynA18461_00735	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynA18461_00736	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynA18461_00737	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynA18461_00743	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA18461_00744	COG0440	acetolactate synthase activity
SynA18461_00745	COG2267	carboxylic ester hydrolase activity
SynA18461_00750	COG2226	methyltransferase
SynA18461_00752	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynA18461_00753	COG0492	ferredoxin-NADP+ reductase activity
SynA18461_00765	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynA18461_00766	COG0733	neurotransmitter:sodium symporter activity
SynA18461_00768	COG0215	cysteine-tRNA ligase activity
SynA18461_00770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynA18461_00770	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynA18461_00771	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynA18461_00772	COG0012	GTP binding
SynA18461_00776	COG0601	transmembrane transport
SynA18461_00777	COG4533	DNA binding
SynA18461_00779	COG0460	homoserine dehydrogenase
SynA18461_00780	COG2166	iron-sulfur cluster assembly
SynA18461_00782	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynA18461_00783	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynA18461_00784	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA18461_00788	COG2010	Cytochrome c
SynA18461_00789	COG0742	ribosomal rna small subunit methyltransferase
SynA18461_00790	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynA18461_00791	COG3118	belongs to the thioredoxin family
SynA18461_00792	COG0516	GMP reductase activity
SynA18461_00794	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynA18461_00795	COG0644	oxidoreductase
SynA18461_00797	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynA18461_00798	COG0395	ABC-type sugar transport system, permease component
SynA18461_00803	COG0011	TIGRFAM Protein of
SynA18461_00806	COG0564	pseudouridine synthase activity
SynA18461_00808	COG1480	7TM receptor with intracellular HD hydrolase
SynA18461_00809	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynA18461_00811	COG0142	geranyltranstransferase activity
SynA18461_00813	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynA18461_00815	COG0406	alpha-ribazole phosphatase activity
SynA18461_00816	COG1254	Belongs to the acylphosphatase family
SynA18461_00817	COG1797	cobyrinic acid a,c-diamide synthase activity
SynA18461_00819	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynA18461_00823	COG2205	protein histidine kinase activity
SynA18461_00827	COG0308	aminopeptidase N
SynA18461_00830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA18461_00837	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynA18461_00839	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA18461_00845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SynA18461_00847	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynA18461_00849	COG2197	response regulator
SynA18461_00850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynA18461_00853	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynA18461_00856	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynA18461_00857	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA18461_00858	COG0473	3-isopropylmalate dehydrogenase activity
SynA18461_00859	COG3954	Phosphoribulokinase
SynA18461_00861	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynA18461_00862	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynA18461_00864	COG0673	inositol 2-dehydrogenase activity
SynA18461_00865	COG0191	fructose-bisphosphate aldolase activity
SynA18461_00866	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynA18461_00867	COG0047	phosphoribosylformylglycinamidine synthase activity
SynA18461_00868	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynA18461_00870	COG0668	transmembrane transport
SynA18461_00872	COG0640	Transcriptional regulator
SynA18461_00873	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA18461_00882	COG5002	protein histidine kinase activity
SynA18461_00889	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynA18461_00892	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA18461_00894	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynA18461_00895	COG1429	ligase activity, forming nitrogen-metal bonds
SynA18461_00897	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynA18461_00898	COG0149	triose-phosphate isomerase activity
SynA18461_00899	COG2501	S4 domain
SynA18461_00900	COG1132	(ABC) transporter
SynA18461_00903	COG1115	amino acid carrier protein
SynA18461_00905	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynA18461_00907	COG0799	negative regulation of ribosome biogenesis
SynA18461_00916	COG0659	secondary active sulfate transmembrane transporter activity
SynA18461_00917	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynA18461_00918	COG4597	amino acid ABC transporter
SynA18461_00919	COG0765	amino acid transport
SynA18461_00928	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynA18461_00935	COG0625	glutathione transferase activity
SynA18461_00942	COG1799	cell septum assembly
SynA18461_00945	COG0735	belongs to the Fur family
SynA18461_00948	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SynA18461_00956	COG0259	pyridoxamine-phosphate oxidase activity
SynA18461_00958	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynA18461_00968	COG4106	trans-aconitate 2-methyltransferase activity
SynA18461_00999	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynA18461_01001	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynA18461_01007	COG0745	RESPONSE REGULATOR receiver
SynA18461_01009	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynA18461_01010	COG0271	Belongs to the BolA IbaG family
SynA18461_01013	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynA18461_01016	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SynA18461_01017	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynA18461_01020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynA18461_01022	COG0513	Belongs to the DEAD box helicase family
SynA18461_01025	COG0724	RNA recognition motif
SynA18461_01026	COG1132	(ABC) transporter
SynA18461_01027	COG0475	glutathione-regulated potassium exporter activity
SynA18461_01027	COG0589	response to stress
SynA18461_01030	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynA18461_01031	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynA18461_01036	COG1054	Belongs to the UPF0176 family
SynA18461_01037	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynA18461_01038	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynA18461_01039	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynA18461_01040	COG0019	diaminopimelate decarboxylase activity
SynA18461_01041	COG0456	acetyltransferase
SynA18461_01042	COG0542	response to heat
SynA18461_01043	COG0371	Dehydrogenase
SynA18461_01044	COG0596	Alpha beta hydrolase
SynA18461_01046	COG0575	Belongs to the CDS family
SynA18461_01047	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynA18461_01048	COG1982	Orn Lys Arg decarboxylase major
SynA18461_01049	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA18461_01051	COG0745	RESPONSE REGULATOR receiver
SynA18461_01052	COG5002	protein histidine kinase activity
SynA18461_01053	COG1187	pseudouridine synthase activity
SynA18461_01082	COG2274	protein secretion by the type I secretion system
SynA18461_01086	COG1640	4-alpha-glucanotransferase
SynA18461_01090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynA18461_01093	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA18461_01094	COG1121	(ABC) transporter
SynA18461_01099	COG0701	Predicted permease
SynA18461_01123	COG0681	Belongs to the peptidase S26 family
SynA18461_01125	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynA18461_01126	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynA18461_01127	COG1376	ErfK ybiS ycfS ynhG family protein
SynA18461_01128	COG0297	glycogen (starch) synthase activity
SynA18461_01130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynA18461_01131	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynA18461_01133	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynA18461_01134	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynA18461_01135	COG2045	Belongs to the ComB family
SynA18461_01137	COG0860	N-Acetylmuramoyl-L-alanine amidase
SynA18461_01138	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynA18461_01139	COG0142	geranyltranstransferase activity
SynA18461_01140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynA18461_01141	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynA18461_01143	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA18461_01144	COG2176	DNA-directed DNA polymerase activity
SynA18461_01146	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA18461_01147	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA18461_01151	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA18461_01153	COG1132	(ABC) transporter
SynA18461_01155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynA18461_01156	COG0505	Belongs to the CarA family
SynA18461_01158	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynA18461_01159	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA18461_01161	COG0154	amidase activity
SynA18461_01162	COG0587	DNA-directed DNA polymerase activity
SynA18461_01164	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynA18461_01165	COG0632	four-way junction helicase activity
SynA18461_01169	COG0358	DNA primase activity
SynA18461_01170	COG0798	PFAM Bile acid sodium symporter
SynA18461_01175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynA18461_01178	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynA18461_01181	COG0792	nuclease activity
SynA18461_01193	COG0792	nuclease activity
SynA18461_01194	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynA18461_01195	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynA18461_01197	COG0022	dehydrogenase e1 component
SynA18461_01197	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynA18461_01198	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynA18461_01199	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynA18461_01215	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynA18461_01216	COG0515	serine threonine protein kinase
SynA18461_01221	COG2226	methyltransferase
SynA18461_01222	COG0174	glutamine synthetase
SynA18461_01224	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynA18461_01228	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynA18461_01232	COG0612	Peptidase, M16
SynA18461_01238	COG1216	Glycosyl transferase, family 2
SynA18461_01239	COG0052	Belongs to the universal ribosomal protein uS2 family
SynA18461_01240	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynA18461_01242	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynA18461_01243	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynA18461_01244	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynA18461_01245	COG0751	glycine-tRNA ligase activity
SynA18461_01247	COG0644	oxidoreductase
SynA18461_01249	COG0826	peptidase U32
SynA18461_01250	COG1217	gtp-binding protein TYPA
SynA18461_01255	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynA18461_01257	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynA18461_01258	COG1494	fructose-1,6-bisphosphatase
SynA18461_01259	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynA18461_01260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA18461_01261	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynA18461_01262	COG0363	glucosamine-6-phosphate deaminase activity
SynA18461_01265	COG0129	dihydroxy-acid dehydratase activity
SynA18461_01267	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynA18461_01273	COG0300	oxidoreductase activity
SynA18461_01328	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SynA18461_01329	COG4106	trans-aconitate 2-methyltransferase activity
SynA18461_01330	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynA18461_01334	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynA18461_01339	COG1836	PFAM Integral membrane protein DUF92
SynA18461_01345	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynA18461_01346	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynA18461_01347	COG0436	Aminotransferase
SynA18461_01349	COG1573	uracil-dna glycosylase
SynA18461_01350	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynA18461_01351	COG0793	Belongs to the peptidase S41A family
SynA18461_01353	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynA18461_01357	COG0861	Integral membrane protein TerC family
SynA18461_01361	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynA18461_01363	COG0312	modulator of DNA gyrase
SynA18461_01364	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynA18461_01367	COG0163	prenyltransferase activity
SynA18461_01368	COG0557	exoribonuclease II activity
SynA18461_01370	COG2119	membrane
SynA18461_01373	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynA18461_01373	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynA18461_01377	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynA18461_01378	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA18461_01379	COG1615	UPF0182 protein
SynA18461_01380	COG0450	alkyl hydroperoxide reductase
SynA18461_01382	COG0739	heme binding
SynA18461_01384	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynA18461_01390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynA18461_01391	COG0445	tRNA wobble uridine modification
SynA18461_01392	COG0557	exoribonuclease II activity
SynA18461_01393	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynA18461_01394	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynA18461_01395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynA18461_01395	COG0072	phenylalanine-tRNA ligase activity
SynA18461_01396	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynA18461_01408	COG0646	methionine synthase
SynA18461_01408	COG1410	methionine synthase
SynA18461_01409	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynA18461_01413	COG1981	membrane
SynA18461_01414	COG3046	protein related to deoxyribodipyrimidine photolyase
SynA18461_01416	COG0322	excinuclease ABC activity
SynA18461_01418	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynA18461_01420	COG2027	D-alanyl-D-alanine carboxypeptidase
SynA18461_01424	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynA18461_01425	COG0495	leucyl-tRNA aminoacylation
SynA18461_01426	COG0166	Belongs to the GPI family
SynA18461_01431	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynA18461_01432	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynA18461_01433	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynA18461_01433	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynA18461_01434	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA18461_01435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynA18461_01436	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynA18461_01438	COG0484	heat shock protein binding
SynA18461_01439	COG0443	Heat shock 70 kDa protein
SynA18461_01440	COG0573	inorganic phosphate transmembrane transporter activity
SynA18461_01441	COG0581	inorganic phosphate transmembrane transporter activity
SynA18461_01442	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynA18461_01446	COG0633	Ferredoxin
SynA18461_01447	COG0483	inositol monophosphate 1-phosphatase activity
SynA18461_01448	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynA18461_01450	COG0326	Molecular chaperone. Has ATPase activity
SynA18461_01451	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynA18461_01452	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA18461_01453	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynA18461_01454	COG1653	transport
SynA18461_01459	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA18461_01464	COG0644	oxidoreductase
SynA18461_01465	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynA18461_01466	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynA18461_01471	COG0469	pyruvate kinase activity
SynA18461_01472	COG1136	(ABC) transporter
SynA18461_01472	COG0577	efflux transmembrane transporter activity
SynA18461_01473	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA18461_01476	COG0740	serine-type endopeptidase activity
SynA18461_01480	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynA18461_01485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynA18461_01486	COG1175	transmembrane transport
SynA18461_01487	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynA18461_01500	COG1793	dna ligase
SynA18461_01501	COG1201	RNA secondary structure unwinding
SynA18461_01503	COG2059	Chromate
SynA18461_01515	COG2226	methyltransferase
SynA18461_01524	COG1119	ATPase activity
SynA18461_01526	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA18461_01529	COG1121	(ABC) transporter
SynA18461_01530	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynA18461_01531	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynA18461_01532	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA18461_01559	COG0724	RNA recognition motif
SynA18461_01579	COG2197	response regulator
SynA18461_01583	COG0189	ligase activity
SynA18461_01583	COG4067	protein conserved in archaea
SynA18461_01584	COG2197	response regulator
SynA18461_01593	COG0405	Gamma-glutamyltransferase
SynA18461_01613	COG2124	cytochrome p450
SynA18461_01621	COG0010	Belongs to the arginase family
SynA18461_01622	COG0375	protein maturation
SynA18461_01625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynA18461_01626	COG1116	anion transmembrane transporter activity
SynA18461_01627	COG4638	Rieske (2fe-2S)
SynA18461_01631	COG2144	transferase activity, transferring acyl groups
SynA18461_01636	COG2072	flavoprotein involved in K transport
SynA18461_01638	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SynA18461_01664	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynA18461_01672	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA18461_01695	COG0786	glutamate:sodium symporter activity
SynA18461_01701	COG0180	Tryptophanyl-tRNA synthetase
SynA18461_01704	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynA18461_01706	COG0837	glucose binding
SynA18461_01707	COG0083	homoserine kinase activity
SynA18461_01708	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA18461_01709	COG0339	signal peptide processing
SynA18461_01712	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynA18461_01721	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynA18461_01722	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynA18461_01724	COG3794	PFAM blue (type 1) copper domain protein
SynA18461_01730	COG0542	response to heat
SynA18461_01732	COG0140	phosphoribosyl-ATP diphosphatase activity
SynA18461_01732	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynA18461_01736	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA18461_01743	COG2010	Cytochrome c
SynA18461_01746	COG0159	tryptophan synthase activity
SynA18461_01751	COG0418	dihydroorotase activity
SynA18461_01752	COG0659	secondary active sulfate transmembrane transporter activity
SynA18461_01753	COG0530	calcium, potassium:sodium antiporter activity
SynA18461_01757	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynA18461_01758	COG1845	cytochrome c oxidase, subunit III
SynA18461_01761	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynA18461_01764	COG0037	tRNA processing
SynA18461_01765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynA18461_01766	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA18461_01769	COG0456	acetyltransferase
SynA18461_01770	COG1132	(ABC) transporter
SynA18461_01771	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynA18461_01772	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynA18461_01773	COG3842	ATPase activity
SynA18461_01816	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynA18461_01820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynA18461_01821	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA18461_01822	COG2135	peptidase activity
SynA18461_01823	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA18461_01828	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynA18461_01828	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynA18461_01837	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynA18461_01838	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynA18461_01839	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynA18461_01841	COG0196	riboflavin kinase activity
SynA18461_01843	COG0352	thiamine-phosphate diphosphorylase activity
SynA18461_01847	COG1691	(AIR) carboxylase
SynA18461_01849	COG0336	Belongs to the RNA methyltransferase TrmD family
SynA18461_01852	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynA18461_01854	COG0670	Belongs to the BI1 family
SynA18461_01855	COG1702	phosphate starvation-inducible protein PhoH
SynA18461_01856	COG0228	four-way junction DNA binding
SynA18461_01857	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynA18461_01859	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynA18461_01860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA18461_01862	COG0482	sulfurtransferase activity
SynA18461_01863	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynA18461_01869	COG0134	indole-3-glycerol-phosphate synthase activity
SynA18461_01870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynA18461_01871	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA18461_01874	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynA18461_01875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynA18461_01876	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynA18461_01877	COG0285	dihydrofolate synthase activity
SynA18461_01883	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA18461_01884	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynA18461_01887	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynA18461_01888	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynA18461_01889	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynA18461_01890	COG4956	integral membrane protein (PIN domain superfamily)
SynA18461_01891	COG0740	serine-type endopeptidase activity
SynA18461_01892	COG0740	serine-type endopeptidase activity
SynA18461_01893	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynA18461_01894	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynA18461_01914	COG2094	Belongs to the DNA glycosylase MPG family
SynA18461_01928	COG0752	glycyl-tRNA synthetase alpha subunit
SynA18461_01931	COG2226	methyltransferase
SynA18461_01932	COG0107	imidazoleglycerol-phosphate synthase activity
SynA18461_01934	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynA18461_01935	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynA18461_01936	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynA18461_01936	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynA18461_01937	COG3695	enzyme binding
SynA18461_01938	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA18461_01946	COG0745	RESPONSE REGULATOR receiver
SynA18461_01947	COG2205	protein histidine kinase activity
SynA18461_01948	COG2205	protein histidine kinase activity
SynA18461_01956	COG0481	GTPase activity
SynA18461_01958	COG0579	oxidoreductase
SynA18461_01959	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynA18461_01963	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynA18461_01967	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SynA18461_01968	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynA18461_01971	COG0556	nucleotide-excision repair
SynA18461_01986	COG3239	Fatty acid desaturase
SynA18461_01995	COG0424	maF-like protein
SynA18461_01997	COG1492	cobalamin metabolic process
SynA18461_02003	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA18461_02004	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynA18461_02005	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA18461_02010	COG4451	ribulose bisphosphate carboxylase, small
SynA18461_02011	COG1850	ribulose-bisphosphate carboxylase activity
SynA18461_02012	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA18461_02013	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynA18461_02014	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA18461_02016	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynA18461_02017	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynA18461_02018	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynA18461_02023	COG0730	response to heat
SynA18461_02024	COG0095	Lipoate-protein ligase
SynA18461_02025	COG0517	IMP dehydrogenase activity
SynA18461_02025	COG1994	Peptidase M50
SynA18461_02026	COG0135	phosphoribosylanthranilate isomerase activity
SynA18461_02027	COG0302	gtp cyclohydrolase
SynA18461_02028	COG0300	oxidoreductase activity
SynA18461_02029	COG0825	malonyl-CoA metabolic process
SynA18461_02030	COG5322	oxidoreductase activity
SynA18461_02031	COG3396	Phenylacetate-CoA oxygenase
SynA18461_02033	COG0539	negative regulation of cytoplasmic translation
SynA18461_02035	COG1496	oxidoreductase activity
SynA18461_02036	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynA18461_02040	COG0028	Belongs to the TPP enzyme family
SynA18461_02041	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA18461_02043	COG2226	methyltransferase
SynA18461_02046	COG0528	UMP kinase activity
SynA18461_02047	COG0233	cytoplasmic translational termination
SynA18461_02053	COG0415	Belongs to the DNA photolyase family
SynA18461_02055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynA18461_02056	COG0768	penicillin binding
SynA18461_02059	COG0588	phosphoglycerate mutase activity
SynA18461_02065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynA18461_02068	COG0442	prolyl-tRNA aminoacylation
SynA18461_02070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynA18461_02071	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynA18461_02073	COG0629	single-stranded DNA binding
SynA18461_02076	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynA18461_02078	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynA18461_02079	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA18461_02081	COG0181	hydroxymethylbilane synthase activity
SynA18461_02084	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynA18461_02085	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynA18461_02089	COG0432	Pfam Uncharacterised protein family UPF0047
SynA18461_02090	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynA18461_02091	COG0523	cobalamin synthesis protein
SynA18461_02093	COG1840	ABC-type Fe3 transport system, periplasmic component
SynA18461_02098	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynA18461_02099	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA18461_02103	COG0708	Exodeoxyribonuclease III
SynA18461_02104	COG0277	FAD linked oxidase domain protein
SynA18461_02105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynA18461_02107	COG0295	cytidine deaminase activity
SynA18461_02109	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SynA18461_02111	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA18461_02112	COG1666	GTP binding
SynA18461_02115	COG0857	belongs to the CobB CobQ family
SynA18461_02117	COG3000	fatty acid hydroxylase
SynA18461_02117	COG0300	oxidoreductase activity
SynA18461_02118	COG0024	Methionine aminopeptidase
SynA18461_02120	COG0335	large ribosomal subunit rRNA binding
SynA18461_02124	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA18461_02127	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SynA18461_02129	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA18461_02130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynA18461_02133	COG0194	GDP metabolic process
SynA18461_02134	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynA18461_02135	COG0805	protein transport
SynA18461_02137	COG0723	plastoquinol--plastocyanin reductase activity
SynA18461_02138	COG0739	heme binding
SynA18461_02139	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynA18461_02140	COG2875	Belongs to the precorrin methyltransferase family
SynA18461_02143	COG0248	Ppx GppA phosphatase
SynA18461_02144	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynA18461_02145	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynA18461_02146	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynA18461_02149	COG1028	Short-chain dehydrogenase reductase Sdr
SynA18461_02151	COG0459	protein refolding
SynA18461_02152	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynA18461_02156	COG0109	protoheme IX farnesyltransferase activity
SynA18461_02157	COG1612	heme a metabolic process
SynA18461_02158	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynA18461_02160	COG1845	cytochrome c oxidase, subunit III
SynA18461_02166	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynA18461_02169	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynA18461_02170	COG1007	ATP synthesis coupled electron transport
SynA18461_02171	COG0577	efflux transmembrane transporter activity
SynA18461_02171	COG1136	(ABC) transporter
SynA18461_02175	COG0436	Aminotransferase
SynA18461_02176	COG3118	belongs to the thioredoxin family
SynA18461_02177	COG1842	Phage shock protein A
SynA18461_02179	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynA18461_02181	COG0697	spore germination
SynA18461_02183	COG0616	signal peptide processing
SynA18461_02187	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynA18461_02188	COG0594	ribonuclease P activity
SynA18461_02190	COG0706	membrane insertase activity
SynA18461_02192	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA18461_02194	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynA18461_02195	COG0750	zinc metalloprotease
SynA18461_02196	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynA18461_02197	COG1185	polyribonucleotide nucleotidyltransferase activity
SynA18461_02199	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynA18461_02231	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SynA18461_02232	COG2226	methyltransferase
SynA18461_02234	COG4176	ABC-type proline glycine betaine transport system permease component
SynA18461_02235	COG2113	Glycine betaine
SynA18461_02240	COG2988	succinylglutamate desuccinylase activity
SynA18461_02241	COG0435	Glutathione S-transferase
SynA18461_02243	COG0488	(ABC) transporter
SynA18461_02246	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynA18461_02249	COG1193	negative regulation of DNA recombination
SynA18461_02251	COG0113	porphobilinogen synthase activity
SynA18461_02252	COG0484	heat shock protein binding
SynA18461_02253	COG4243	Vitamin k epoxide reductase
SynA18461_02254	COG0659	secondary active sulfate transmembrane transporter activity
SynA18461_02257	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynA18461_02269	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SynA18461_02276	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynA18461_02277	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynA18461_02279	COG1012	belongs to the aldehyde dehydrogenase family
SynA18461_02280	COG0741	lytic transglycosylase activity
SynA18461_02280	COG1388	LysM domain
SynA18461_02284	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynA18461_02285	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynA18461_02287	COG0235	Class ii aldolase
SynA18461_02288	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynA18461_02296	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynA18461_02297	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynA18461_02298	COG0793	Belongs to the peptidase S41A family
SynA18461_02299	COG1078	dGTPase activity
SynA18461_02300	COG0850	regulation of cytokinetic process
SynA18461_02301	COG2894	cell division
SynA18461_02302	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynA18461_02306	COG0009	L-threonylcarbamoyladenylate synthase
SynA18461_02307	COG2890	protein-(glutamine-N5) methyltransferase activity
SynA18461_02308	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynA18461_02308	COG0758	DNA mediated transformation
SynA18461_02314	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynA18461_02316	COG0539	negative regulation of cytoplasmic translation
SynA18461_02317	COG0546	phosphoglycolate phosphatase activity
SynA18461_02318	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynA18461_02319	COG1070	Carbohydrate kinase
SynA18461_02323	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynA18461_02344	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA18461_02377	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynA18461_02378	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynA18461_02378	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynA18461_02379	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynA18461_02381	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynA18461_02383	COG4989	oxidoreductase activity
SynA18461_02389	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SynA18461_02393	COG0408	coproporphyrinogen oxidase activity
SynA18461_02394	COG0489	protein tyrosine kinase activity
SynA18461_02395	COG0772	Belongs to the SEDS family
SynA18461_02398	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynA18461_02400	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynA18461_02403	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynA18461_02404	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynA18461_02405	COG1606	tRNA processing
SynA18461_02406	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynA18461_02410	COG3001	Fructosamine kinase
SynA18461_02411	COG1233	COG1233 Phytoene dehydrogenase and related
SynA18461_02416	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynA18461_02419	COG3854	ATPases associated with a variety of cellular activities
SynA18461_02422	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynA18461_02423	COG0088	Forms part of the polypeptide exit tunnel
SynA18461_02424	COG0089	rRNA binding
SynA18461_02425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynA18461_02426	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynA18461_02427	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynA18461_02428	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynA18461_02429	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynA18461_02430	COG0255	Belongs to the universal ribosomal protein uL29 family
SynA18461_02431	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynA18461_02432	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynA18461_02433	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynA18461_02434	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynA18461_02435	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynA18461_02436	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynA18461_02437	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynA18461_02438	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynA18461_02439	COG0200	Binds to the 23S rRNA
SynA18461_02440	COG0201	protein transport
SynA18461_02441	COG0563	adenylate kinase activity
SynA18461_02442	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynA18461_02443	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynA18461_02444	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynA18461_02445	COG0202	RNA polymerase activity
SynA18461_02446	COG0203	ribosomal protein L17
SynA18461_02447	COG0101	tRNA pseudouridine synthase activity
SynA18461_02448	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynA18461_02449	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynA18461_02450	COG0254	rRNA binding
SynA18461_02451	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynA18461_02453	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynA18461_02463	COG0463	Glycosyl transferase, family 2
SynA18461_02471	COG2885	chlorophyll binding
SynA18461_02472	COG2885	chlorophyll binding
SynA18461_02479	COG3659	wide pore channel activity
SynA18461_02481	COG3128	pkhd-type hydroxylase
SynA18461_02482	COG1840	ABC-type Fe3 transport system, periplasmic component
SynA18461_02490	COG3659	wide pore channel activity
SynA18461_02495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynA18461_02497	COG0067	glutamate synthase
SynA18461_02497	COG0070	glutamate synthase
SynA18461_02497	COG0069	glutamate synthase activity
SynA18461_02500	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynA18461_02501	COG0049	tRNA binding
SynA18461_02502	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynA18461_02503	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynA18461_02504	COG0051	transcription antitermination factor activity, RNA binding
SynA18461_02505	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynA18461_02506	COG2226	methyltransferase
SynA18461_02509	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynA18461_02510	COG1530	ribonuclease E activity
SynA18461_02512	COG0436	Aminotransferase
SynA18461_02513	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynA18461_02520	COG0033	Phosphoglucomutase
SynA18461_02522	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynA18461_02524	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SynA18461_02528	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA18461_02529	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynA18461_02530	COG0175	sulfate reduction
SynA18461_02531	COG1252	NADH dehydrogenase
SynA18461_02532	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynA18461_02533	COG3273	potassium ion transport
SynA18461_02533	COG0471	metal ion transport
SynA18461_02534	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynA18461_02535	COG0569	domain protein
SynA18461_02536	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynA18461_02541	COG0488	(ABC) transporter
SynA18461_02543	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA18461_02547	COG1643	Atp-dependent helicase
SynA18461_02548	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA18461_02550	COG1570	exodeoxyribonuclease VII activity
SynA18461_02551	COG1722	exodeoxyribonuclease VII activity
SynA18461_02564	COG1968	undecaprenyl-diphosphatase activity
SynA18461_02566	COG1555	photosystem II stabilization
SynA18461_02567	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynA18461_02568	COG4243	Vitamin k epoxide reductase
SynA18461_02569	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA18461_02571	COG1032	radical SAM domain protein
SynA18461_02577	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynA18461_02582	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynA18461_02583	COG1472	Belongs to the glycosyl hydrolase 3 family
SynA18461_02584	COG0463	Glycosyl transferase, family 2
SynA18461_02584	COG0457	Tetratricopeptide repeat
SynA18461_02585	COG1587	Uroporphyrinogen-III synthase
SynA18461_02588	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynA18461_02589	COG0316	Belongs to the HesB IscA family
SynA18461_02593	COG1090	epimerase
SynA18461_02597	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynA18461_02598	COG3659	wide pore channel activity
SynA18461_02600	COG3659	wide pore channel activity
SynA18461_02601	COG3659	wide pore channel activity
SynA18461_02602	COG3659	wide pore channel activity
SynA18461_02603	COG3659	wide pore channel activity
SynA18461_02611	COG1122	ATPase activity
SynA18461_02614	COG0745	RESPONSE REGULATOR receiver
SynA18461_02616	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynA18461_02617	COG2217	Heavy metal translocating P-type atpase
SynA18461_02618	COG3063	Type IV pilus biogenesis stability protein PilW
SynA18461_02619	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynA18461_02621	COG0416	fatty acid biosynthetic process
SynA18461_02622	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynA18461_02623	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynA18461_02626	COG1214	PFAM Peptidase M22, glycoprotease
SynA18461_02628	COG0617	tRNA 3'-terminal CCA addition
SynA18461_02629	COG0724	RNA recognition motif
SynA18461_02630	COG1562	ergosterol biosynthetic process
SynA18461_02631	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynA18461_02631	COG0493	'glutamate synthase
SynA18461_02634	COG0583	DNA-binding transcription factor activity
SynA18461_02636	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynA18461_02637	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA18461_02640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynA18461_02642	COG2197	response regulator
SynA18461_02645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynA18461_02646	COG0713	ATP synthesis coupled electron transport
SynA18461_02647	COG0839	Belongs to the complex I subunit 6 family
SynA18461_02648	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA18461_02649	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynA18461_02650	COG0372	Belongs to the citrate synthase family
SynA18461_02651	COG2062	phosphohistidine phosphatase, SixA
SynA18461_02654	COG1420	regulation of RNA biosynthetic process
SynA18461_02655	COG0133	tryptophan synthase activity
SynA18461_02656	COG0023	Translation Initiation Factor
SynA18461_02657	COG0529	Catalyzes the synthesis of activated sulfate
SynA18461_02658	COG0628	permease
SynA18461_02659	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynA18461_02660	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SynA18461_02661	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA18461_02662	COG0564	pseudouridine synthase activity
SynA18461_02663	COG0745	RESPONSE REGULATOR receiver
SynA18461_02665	COG1104	cysteine desulfurase activity
SynA18461_02675	COG0275	rRNA processing
SynA18461_02676	COG0649	NAD binding
SynA18461_02678	COG0824	Thioesterase
SynA18461_02686	COG1575	Belongs to the MenA family. Type 1 subfamily
SynA18461_02688	COG0189	ligase activity
SynA18461_02689	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynA18461_02690	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynA18461_02692	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynA18461_02693	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynA18461_02694	COG0512	Glutamine amidotransferase of anthranilate synthase
SynA18461_02696	COG0252	asparaginase activity
SynA18461_02697	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynA18461_02698	COG0018	arginyl-trna synthetase
SynA18461_02699	COG0157	Belongs to the NadC ModD family
SynA18461_02704	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynA18461_02706	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynA18461_02707	COG4172	Belongs to the ABC transporter superfamily
SynA18461_02709	COG0564	pseudouridine synthase activity
SynA18461_02711	COG0589	response to stress
SynA18461_02712	COG0126	phosphoglycerate kinase activity
SynA18461_02716	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynA18461_02717	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynA18461_02723	COG0167	dihydroorotate dehydrogenase activity
SynA18461_02724	COG0328	RNA-DNA hybrid ribonuclease activity
SynA18461_02726	COG0222	ribosome binding
SynA18461_02727	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynA18461_02729	COG0081	regulation of translation
SynA18461_02730	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynA18461_02731	COG0250	Participates in transcription elongation, termination and antitermination
SynA18461_02732	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynA18461_02733	COG0542	response to heat
SynA18461_02734	COG0346	lactoylglutathione lyase activity
SynA18461_02735	COG0148	phosphopyruvate hydratase activity
SynA18461_02736	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA18461_02741	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynA18461_02742	COG0237	dephospho-CoA kinase activity
SynA18461_02744	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA18461_02745	COG2022	thiamine diphosphate biosynthetic process
SynA18461_02745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynA18461_02749	COG0105	UTP biosynthetic process
SynA18461_02751	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SynA18461_02754	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA18461_02757	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynA18461_02759	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynA18461_02765	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynA18461_02765	COG0426	domain, Protein
SynA18461_02766	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynA18461_02766	COG0426	domain, Protein
SynA18461_02768	COG1733	regulation of RNA biosynthetic process
SynA18461_02770	COG1741	Belongs to the pirin family
SynA18461_02774	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynA18461_02774	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynA18461_02775	COG0509	glycine decarboxylation via glycine cleavage system
SynA18461_02776	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynA18461_02778	COG0359	binds to the 23S rRNA
SynA18461_02779	COG1372	Participates in initiation and elongation during chromosome replication
SynA18461_02779	COG0305	Participates in initiation and elongation during chromosome replication
SynA18461_02779	COG1372	Participates in initiation and elongation during chromosome replication
SynA18461_02779	COG0305	Participates in initiation and elongation during chromosome replication
SynA18461_02782	COG0445	tRNA wobble uridine modification
SynA18461_02789	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynA18461_02795	COG0398	Pfam SNARE associated Golgi protein
SynA18461_02799	COG0525	valine-tRNA ligase activity
SynA18461_02803	COG4221	oxidoreductase activity
SynA18461_02842	COG3956	TIGRFAM MazG family protein
SynA18461_02844	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynA18461_02845	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynA18461_02846	COG0010	Belongs to the arginase family
SynA18461_02849	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynA18461_02850	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynA18461_02852	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA18461_02853	COG0504	CTP synthase activity
SynA18461_02854	COG0602	queuosine metabolic process
SynA18461_02855	COG2084	Dehydrogenase
SynA18461_02856	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynA18461_02860	COG0366	Alpha amylase catalytic
SynA18461_02861	COG0463	Glycosyl transferase, family 2
SynA18461_02869	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynA18461_02870	COG0830	nickel cation binding
SynA18461_02871	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynA18461_02872	COG0829	nickel cation binding
SynA18461_02873	COG0831	urea catabolic process
SynA18461_02874	COG0832	Belongs to the urease beta subunit family
SynA18461_02875	COG0804	urea catabolic process
SynA18461_02879	COG0367	asparagine synthase
SynA18461_02880	COG0540	Belongs to the ATCase OTCase family
SynA18461_02885	COG2308	Evidence 4 Homologs of previously reported genes of
SynA18461_02889	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynA18461_02890	COG0746	molybdenum cofactor guanylyltransferase activity
SynA18461_02892	COG2223	nitrite transmembrane transporter activity
SynA18461_02893	COG0243	molybdopterin cofactor binding
SynA18461_02898	COG0315	cyclic pyranopterin monophosphate synthase activity
SynA18461_02899	COG0303	'Molybdopterin
SynA18461_02902	COG0314	molybdopterin synthase activity
SynA18461_02904	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynA18461_02905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynA18461_02908	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynA18461_02911	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA18461_02912	COG1121	(ABC) transporter
SynA18461_02913	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynA18461_02914	COG0523	cobalamin synthesis protein
SynA18461_02918	COG1116	anion transmembrane transporter activity
SynA18461_02919	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynA18461_02920	COG1116	anion transmembrane transporter activity
SynA18461_02920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SynA18461_02921	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynA18461_02923	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynA18461_02926	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynA18461_02929	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynA18461_02930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA18461_02931	COG0170	dolichyl monophosphate biosynthetic process
SynA18461_02933	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynA18461_02934	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynA18461_02935	COG0038	chloride channel
SynA18461_02937	COG0788	formyltetrahydrofolate deformylase activity
SynA18461_02939	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynA18461_02940	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA18461_02941	COG0443	Heat shock 70 kDa protein
SynA18461_02942	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynA18461_02944	COG0360	Binds together with S18 to 16S ribosomal RNA
SynA18461_02946	COG0137	argininosuccinate synthase activity
SynA18461_02949	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA18461_02952	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynA18461_02953	COG0438	transferase activity, transferring glycosyl groups
SynA18461_02956	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynA18461_02957	COG0497	DNA recombination
SynA18461_02958	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA18461_02960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine