locus-tag class description CB0101_00005 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CB0101_00055 ENOG4105TQG cytochrome C, class I CB0101_00075 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) CB0101_00085 ENOG41069EW electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity) CB0101_00140 ENOG4105BZU Histidine kinase CB0101_00175 ENOG4105KME endoribonuclease L-psp CB0101_00180 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CB0101_00190 ENOG4105CMQ Chloride channel CB0101_00215 ENOG4107QKW extracellular solute-binding protein family 1 CB0101_00235 ENOG4105HF0 Membrane CB0101_00275 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CB0101_00285 ENOG4108QF0 This is one of the two reaction center proteins of photosystem II CB0101_00295 ENOG4105D4P Coproporphyrinogen iii oxidase CB0101_00345 ENOG4108JUA Transcriptional regulator CB0101_00375 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CB0101_00390 ENOG4105DWF phosphomethylpyrimidine kinase CB0101_00410 ENOG4105CAQ asparagine synthetase CB0101_00445 ENOG4107FQX Alpha-acetolactate decarboxylase CB0101_00460 ENOG4105CI2 imidazolone-5-propionate hydrolase CB0101_00475 ENOG4105C57 major facilitator superfamily CB0101_00480 ENOG4105C5I Dehydrogenase CB0101_00495 ENOG4108RIN C-phycoerythrin class I beta chain CB0101_00515 ENOG4105F2I Transposase CB0101_00545 ENOG4105CSR polyphosphate kinase 2 CB0101_00565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CB0101_00670 ENOG4105QUW CB0101_00680 ENOG410802X bacteriophage n4 adsorption protein b CB0101_00690 ENOG4105BZU Histidine kinase CB0101_00720 ENOG41062D9 Histidine kinase CB0101_00785 ENOG4105F2I Transposase CB0101_00815 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CB0101_00820 ENOG41069ZX CB0101_00860 ENOG4105CHH sulfate transporter CB0101_00870 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CB0101_00920 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CB0101_00930 ENOG4105BZG amino acid carrier protein CB0101_00950 ENOG4105DC8 reductase CB0101_00955 ENOG4105E2X shikimate dehydrogenase CB0101_01000 ENOG4108MZQ phycobilisome linker polypeptide CB0101_01010 ENOG4105EKE dihydroorotase CB0101_01015 ENOG410864U UPF0235 protein CB0101_01025 ENOG4105BZU Histidine kinase CB0101_01075 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) CB0101_01085 ENOG4105WH1 Two component transcriptional regulator luxr family CB0101_01150 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CB0101_01155 ENOG4105KBH arsR family transcriptional regulator CB0101_01160 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CB0101_01165 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) CB0101_01170 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CB0101_01180 ENOG4105C8U phosphate abc transporter CB0101_01185 ENOG4105E2Z phosphate ABC transporter (Permease CB0101_01190 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CB0101_01200 ENOG4105F2I Transposase CB0101_01235 ENOG4105C54 Major Facilitator superfamily CB0101_01245 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CB0101_01270 ENOG4105D7N magnesium and cobalt transport protein CorA CB0101_01295 ENOG4105EB3 Histidine kinase CB0101_01300 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CB0101_01345 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family CB0101_01360 ENOG4105C6T cysteine synthase CB0101_01370 ENOG4105BZ1 (ABC) transporter CB0101_01380 ENOG4105CP7 Triose-phosphate isomerase CB0101_01390 ENOG4105BZU Histidine kinase CB0101_01395 ENOG4107QZ7 Cellulose synthase catalytic subunit CB0101_01410 ENOG4105CTK cobaltochelatase, cobn subunit CB0101_01415 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CB0101_01425 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CB0101_01440 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CB0101_01465 ENOG4105CSR polyphosphate kinase 2 CB0101_01500 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) CB0101_01505 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) CB0101_01520 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) CB0101_01525 ENOG4108JJB ABC transporter CB0101_01565 ENOG4105D5T phosphonate abc transporter CB0101_01575 ENOG4107T9Q phosphonate abc transporter CB0101_01590 ENOG4108UN4 phage SPO1 DNA polymerase-related protein CB0101_01595 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CB0101_01630 ENOG4107TS3 membrane protein, TerC CB0101_01645 ENOG4105C1J atp-dependent rna helicase CB0101_01655 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CB0101_01670 ENOG4105FBB Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity) CB0101_01715 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CB0101_01720 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 CB0101_01730 ENOG4105CAT Cytidine monophosphate kinase CB0101_01735 ENOG41068G9 50S ribosomal protein L32 CB0101_01740 ENOG4108790 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CB0101_01780 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) CB0101_01795 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) CB0101_01800 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CB0101_01805 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CB0101_01810 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CB0101_01825 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CB0101_01850 ENOG4105DWV Homoserine O-trans-acetylase CB0101_01860 ENOG4105C9Q fumarate hydratase class II CB0101_01880 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CB0101_01895 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CB0101_01915 ENOG4105CYM Glutathione S-transferase CB0101_01990 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CB0101_02015 ENOG4105JZI cytochrome P450 CB0101_02050 ENOG41084W5 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CB0101_02125 ENOG410811Q Ferredoxin CB0101_02130 ENOG4105C6K Malic enzyme CB0101_02170 ENOG4107QRT dEAD DEAH box helicase CB0101_02175 ENOG4107T0X DNA ligase CB0101_02185 ENOG4107R1Y fructose-bisphosphate aldolase CB0101_02220 ENOG4105D49 3-dehydroquinate synthase CB0101_02225 ENOG4105C9U ATP-dependent DNA helicase RecQ CB0101_02230 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component CB0101_02235 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CB0101_02280 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) CB0101_02290 ENOG4108R9R May be involved in photosynthetic membrane biogenesis (By similarity) CB0101_02295 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CB0101_02305 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CB0101_02330 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CB0101_02360 ENOG4105C7B Threonine dehydratase CB0101_02365 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CB0101_02375 ENOG4105VGQ Photosystem I subunit X CB0101_02435 ENOG4108DJF Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CB0101_02515 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CB0101_02520 ENOG41083EU 50s ribosomal protein l28 CB0101_02530 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CB0101_02535 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CB0101_02555 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CB0101_02570 ENOG4107T3P ABC, transporter CB0101_02600 ENOG410811H Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) CB0101_02620 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CB0101_02625 ENOG4105E2Z phosphate ABC transporter (Permease CB0101_02630 ENOG4105C8U phosphate abc transporter CB0101_02640 ENOG4105DVC DnaJ domain protein CB0101_02650 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CB0101_02655 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) CB0101_02660 ENOG4108ZCU PPIases accelerate the folding of proteins CB0101_02670 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CB0101_02675 ENOG4108V3E phosphoribosylglycinamide formyltransferase CB0101_02700 ENOG4105C89 phosphohexose isomerase CB0101_02705 ENOG4105C8T Leucyl-tRNA synthetase CB0101_02715 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CB0101_02745 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CB0101_02755 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CB0101_02765 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein CB0101_02780 ENOG4105C0B DNA polymerase III (alpha subunit) CB0101_02790 ENOG4105CTK cobaltochelatase, cobn subunit CB0101_02820 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CB0101_02825 ENOG4105JAB phenazine biosynthesis protein, phzf family CB0101_02830 ENOG4105JFG SpoIID LytB domain protein CB0101_02870 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CB0101_02875 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CB0101_02880 ENOG41084GG 50S ribosomal protein L33 CB0101_02885 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CB0101_02910 ENOG4106PGW Short-chain dehydrogenase reductase Sdr CB0101_02920 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) CB0101_02970 ENOG4108MV2 Involved in light-induced Na( )-dependent proton extrusion. Also seems to be involved in CO(2) transport (By similarity) CB0101_02985 ENOG4108K5P (LipO)protein CB0101_03050 ENOG4105DQ4 alcohol dehydrogenase CB0101_03090 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CB0101_03105 ENOG4107QRP cobalamin biosynthesis protein CobW CB0101_03120 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CB0101_03130 ENOG4105C01 Dihydroxy-acid dehydratase CB0101_03155 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CB0101_03160 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CB0101_03165 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CB0101_03170 ENOG4105CBT Fructose-1,6-bisphosphatase CB0101_03180 ENOG4105CRE cytochrome C CB0101_03190 ENOG4108IUZ ABC transporter CB0101_03210 ENOG4105CFP Peptidase U32 CB0101_03230 ENOG4105C38 Glycyl-tRNA synthetase beta subunit CB0101_03255 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CB0101_03260 ENOG4105CE9 30S ribosomal protein S2 CB0101_03265 ENOG4107R51 Glycosyl transferase, family 2 CB0101_03275 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) CB0101_03285 ENOG4105ENT Efflux transporter rnd family, mfp subunit CB0101_03290 ENOG4105E67 Catalyzes the four-electron reduction of biliverdin IX- alpha (2-electron reduction at both the A and D rings) CB0101_03295 ENOG4105C1V Peptidase, M16 CB0101_03315 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CB0101_03320 ENOG4105BZ4 penicillin-binding protein CB0101_03325 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CB0101_03340 ENOG4108Z6B deaminase CB0101_03345 ENOG4105C5R Aminotransferase CB0101_03350 ENOG4108TCG allophycocyanin beta subunit CB0101_03355 ENOG4105C5F glutamine synthetase CB0101_03390 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) CB0101_03395 ENOG4105MSA Photosystem II reaction center W protein CB0101_03415 ENOG4107TV7 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CB0101_03420 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CB0101_03425 ENOG4105CPP Dehydrogenase, E1 component CB0101_03435 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) CB0101_03440 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CB0101_03475 ENOG4105KT5 UmuD protein CB0101_03480 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CB0101_03490 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CB0101_03505 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CB0101_03510 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CB0101_03525 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CB0101_03540 ENOG4108420 Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) CB0101_03550 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CB0101_03555 ENOG4108I0Q anthranilate phosphoribosyltransferase CB0101_03565 ENOG4105BZ1 (ABC) transporter CB0101_03575 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CB0101_03605 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CB0101_03610 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CB0101_03620 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CB0101_03625 ENOG4107VXZ Hydrolase CB0101_03635 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CB0101_03650 ENOG4108N5B 2-phosphosulfolactate phosphatase CB0101_03665 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CB0101_03670 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) CB0101_03675 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CB0101_03690 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) CB0101_03695 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein CB0101_03700 ENOG4108IPT Naphthoate synthase CB0101_03705 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CB0101_03735 ENOG4105DSE periplasmic solute binding protein CB0101_03770 ENOG4105EY5 This is one of the two reaction center proteins of photosystem II CB0101_03780 ENOG4105PGM cation diffusion facilitator family transporter CB0101_03795 ENOG4105C31 Tryptophanyl-tRNA synthetase CB0101_03810 ENOG4105C22 threonyL-tRNA synthetase CB0101_03815 ENOG4105CHC glucokinase (EC 2.7.1.2) CB0101_03820 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CB0101_03825 ENOG4105C8S subunit m CB0101_03830 ENOG4105DGW oligopeptidase A CB0101_03865 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) CB0101_03905 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CB0101_03910 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CB0101_03950 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CB0101_04010 ENOG4105CTD carboxy-peptidase CB0101_04015 ENOG4105F0N pyrophosphate phospho-hydrolase CB0101_04025 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CB0101_04040 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) CB0101_04045 ENOG4107QRS glycosyltransferase group 2 family protein CB0101_04050 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CB0101_04065 ENOG4105CAS nag kinase CB0101_04100 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CB0101_04110 ENOG4107QP0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CB0101_04170 ENOG4105CJN penicillin-binding protein CB0101_04175 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CB0101_04190 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CB0101_04195 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CB0101_04200 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CB0101_04210 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CB0101_04250 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit CB0101_04255 ENOG4107QIZ NADH dehydrogenase CB0101_04260 ENOG4108IEH NADH dehydrogenase subunit g CB0101_04265 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CB0101_04280 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) CB0101_04300 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) CB0101_04310 ENOG4105CQS hydrogenase expression formation protein HypD CB0101_04400 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CB0101_04435 ENOG4105VN1 Heat shock protein CB0101_04465 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CB0101_04470 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CB0101_04495 ENOG4105EY5 This is one of the two reaction center proteins of photosystem II CB0101_04500 ENOG4105CAH Chromate CB0101_04515 ENOG4105DZ0 fad dependent oxidoreductase CB0101_04540 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CB0101_04550 ENOG410612X Catalyzes the decarbonylation of fatty aldehydes to alkanes. Requires the presence of ferredoxin, ferredoxin reductase and NADPH for in vitro decarbonylase activity (By similarity). Involved in the biosynthesis of alkanes, mainly heptadecane and pentadecane CB0101_04555 ENOG4105E6N shikimate quinate 5-dehydrogenase CB0101_04560 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CB0101_04570 ENOG4105EUJ GTP cyclohydrolase i CB0101_04580 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase CB0101_04590 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) CB0101_04625 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) CB0101_04630 ENOG4105CI2 imidazolone-5-propionate hydrolase CB0101_04635 ENOG4105EVY Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) CB0101_04640 ENOG4105C78 Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) CB0101_04650 ENOG4105CZN Potassium uptake protein CB0101_04675 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CB0101_04720 ENOG4108ZE9 Monovalent cation H antiporter subunit C CB0101_04725 ENOG4108JPZ Monovalent cation H antiporter subunit D CB0101_04755 ENOG4105CHH sulfate transporter CB0101_04765 ENOG4105WVZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CB0101_04780 ENOG410906A Beta-Ig-H3 fasciclin CB0101_04790 ENOG4105C8S subunit m CB0101_04800 ENOG4105C0X amino acid CB0101_04825 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CB0101_04840 ENOG4105KNY Microcompartments protein CB0101_04845 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate CB0101_04850 ENOG4108VFZ ribulose bisphosphate carboxylase, small CB0101_04875 ENOG4105KNY Microcompartments protein CB0101_04885 ENOG4105D65 subunit l CB0101_04890 ENOG4105C8S subunit m CB0101_04905 ENOG4106F1P AAA ATPase, central domain protein CB0101_04925 ENOG4105FFC UPF0187 protein CB0101_04935 ENOG4108KMM Diguanylate cyclase CB0101_04940 ENOG4107WJM -acetyltransferase CB0101_04950 ENOG4105BZ1 (ABC) transporter CB0101_04955 ENOG4107WMZ Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CB0101_04960 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CB0101_04965 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CB0101_04980 ENOG41063SB peptidase CB0101_05080 ENOG4108V1T peptidylprolyl cis-trans isomerase CB0101_05105 ENOG4105KK6 nuclease CB0101_05155 ENOG4105CJT Mannose-1-phosphate guanylyltransferase CB0101_05180 ENOG4105CKK Glycosyl transferase, family 2 CB0101_05195 ENOG4105E2K Glycosyl transferase (Group 1 CB0101_05205 ENOG4105D3Q Sugar transferase CB0101_05235 ENOG4105VJK Transcription factor CB0101_05250 ENOG4106CD9 glycosyl transferase group 1 CB0101_05275 ENOG4105D3Q Sugar transferase CB0101_05285 ENOG4105FAW cDP-glucose 4,6-dehydratase CB0101_05290 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CB0101_05330 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) CB0101_05365 ENOG4105F2I Transposase CB0101_05375 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CB0101_05390 ENOG4105CMR udp-glucose 4-epimerase CB0101_05395 ENOG4105C30 Nad-dependent epimerase dehydratase CB0101_05400 ENOG4105C0K Gdp-mannose 4,6-dehydratase CB0101_05460 ENOG410624X efflux transporter, rnd family, mfp subunit CB0101_05465 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CB0101_05480 ENOG4108PJD permease CB0101_05520 ENOG41090A1 ferritin CB0101_05535 ENOG4105CKI cobalamin synthesis protein CB0101_05545 ENOG4107XWZ ferric uptake regulator CB0101_05555 ENOG4105C8M UPF0272 protein CB0101_05580 ENOG4105CGK Exodeoxyribonuclease III CB0101_05585 ENOG4105CQB FAD linked oxidase domain protein CB0101_05590 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CB0101_05600 ENOG4105C32 Amino acid ABC transporter (Permease) CB0101_05605 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CB0101_05610 ENOG4105C0Z ABC transporter CB0101_05615 ENOG4108IV0 ABC, transporter CB0101_05630 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CB0101_05645 ENOG4108VPT UPF0234 protein CB0101_05695 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CB0101_05715 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CB0101_05750 ENOG4105C8N cysteinyl-tRNA synthetase CB0101_05760 ENOG4105C8J )-transporter CB0101_05775 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CB0101_05790 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CB0101_05795 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CB0101_05800 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CB0101_05815 ENOG4105C3M thioredoxin reductase CB0101_05865 ENOG4108S5W Seems to be required for the assembly of the photosystem I complex (By similarity) CB0101_05875 ENOG4105E9X Photosystem II 44 kDa subunit reaction center protein CB0101_05930 ENOG4105VXP Protein of unknown function DUF86 CB0101_05940 ENOG4108Z03 MAF-like protein CB0101_05950 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CB0101_05970 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CB0101_05980 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CB0101_06060 ENOG4105DGU Histone deacetylase CB0101_06065 ENOG4108JYK Dehydrogenase CB0101_06075 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY CB0101_06080 ENOG41082B1 30S ribosomal protein S16 CB0101_06090 ENOG4105HFZ Membrane CB0101_06110 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CB0101_06125 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) CB0101_06135 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase CB0101_06155 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CB0101_06170 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) CB0101_06175 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CB0101_06180 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CB0101_06185 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CB0101_06215 ENOG4105IPI Membrane CB0101_06255 ENOG4108RAV Conserved protein CB0101_06265 ENOG4105DBV ornithine carbamoyltransferase CB0101_06350 ENOG4107U7Q Transfers the fatty acyl group on membrane lipoproteins (By similarity) CB0101_06375 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) CB0101_06380 ENOG4105C7S Dehydrogenase CB0101_06390 ENOG4108IQE Amp-dependent synthetase and ligase CB0101_06395 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) CB0101_06420 ENOG4105E2K Glycosyl transferase (Group 1 CB0101_06425 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) CB0101_06435 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CB0101_06475 ENOG4107R50 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CB0101_06485 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CB0101_06490 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CB0101_06495 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CB0101_06505 ENOG4107QPR SAICAR synthetase CB0101_06515 ENOG4105C12 Phosphoribosylglycinamide synthetase CB0101_06525 ENOG4105EHU Circadian clock protein KaiC CB0101_06530 ENOG4108ZGN Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead needs the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC (By similarity) CB0101_06535 ENOG4108WXF Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of KaiC. In contrast, the presence of KaiB in the complex decreases the phosphorylation status of KaiC, suggesting that KaiB acts by antagonizing the interaction between KaiA and KaiC. A KaiA dimer is sufficient to enhance KaiC hexamer phosphorylation CB0101_06540 ENOG41082FX This protein binds to 23S rRNA in the presence of protein L20 (By similarity) CB0101_06545 ENOG4105K46 50S ribosomal protein l27 CB0101_06550 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CB0101_06560 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CB0101_06565 ENOG4105CDY transcriptional regulatory protein CB0101_06570 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CB0101_06575 ENOG4105JFG SpoIID LytB domain protein CB0101_06580 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CB0101_06585 ENOG4108UQX Low-potential cytochrome c that plays a role in the oxygen-evolving complex of photosystem II (By similarity) CB0101_06600 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CB0101_06625 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CB0101_06655 ENOG4105WXN Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) CB0101_06665 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB CB0101_06680 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) CB0101_06695 ENOG4105E0X reductase CB0101_06700 ENOG4105BZU Histidine kinase CB0101_06705 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CB0101_06710 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CB0101_06715 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CB0101_06720 ENOG410823V Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CB0101_06730 ENOG4105BZ4 penicillin-binding protein CB0101_06745 ENOG4107QPV Serine Threonine protein kinase CB0101_06765 ENOG4105KAN Probably a ribosomal protein or a ribosome-associated protein (By similarity) CB0101_06775 ENOG4107RAQ aminopeptidase CB0101_06780 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CB0101_06795 ENOG4105DCF alanine dehydrogenase CB0101_06805 ENOG4105K5B UPF0225 protein CB0101_06830 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CB0101_06835 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CB0101_06845 ENOG4105VYJ F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CB0101_06855 ENOG4105VH4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CB0101_06870 ENOG4107SWE Methyltransferase CB0101_06875 ENOG4105EEK Polypeptide CB0101_06910 ENOG4107Z8Z Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) CB0101_06920 ENOG4105DX0 Hemolysin A CB0101_06935 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) CB0101_06940 ENOG4105CQR helicase CB0101_06960 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CB0101_06975 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CB0101_06980 ENOG4107YBR Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CB0101_06985 ENOG4105CV8 reductase CB0101_06990 ENOG4108ISE 4Fe-4S ferredoxin, iron-sulfur binding CB0101_07010 ENOG4105CK7 Sodium proline symporter CB0101_07015 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CB0101_07020 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CB0101_07025 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CB0101_07030 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CB0101_07035 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CB0101_07045 ENOG41084H8 Binds directly to 16S ribosomal RNA (By similarity) CB0101_07050 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CB0101_07055 ENOG4105E66 phosphoriboisomerase A CB0101_07060 ENOG4105C0H protease CB0101_07065 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) CB0101_07075 ENOG4107ZR3 Required for maturation of 30S ribosomal subunits (By similarity) CB0101_07080 ENOG4105CHV Transcription elongation factor NusA CB0101_07090 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CB0101_07145 ENOG4105CVR type I restriction-modification system CB0101_07150 ENOG4105F2I Transposase CB0101_07230 ENOG4105EY5 This is one of the two reaction center proteins of photosystem II CB0101_07245 ENOG4108Q6X Aspartoacylase (EC 3.5.1.15) CB0101_07260 ENOG4105F2I Transposase CB0101_07285 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) CB0101_07290 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CB0101_07300 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CB0101_07305 ENOG4107Z3D 50S ribosomal protein l10 CB0101_07310 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) CB0101_07315 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CB0101_07330 ENOG4106JDQ ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB CB0101_07340 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CB0101_07365 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CB0101_07370 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CB0101_07390 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CB0101_07395 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CB0101_07405 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CB0101_07425 ENOG410870F Cyclic nucleotide-binding protein CB0101_07430 ENOG4106TD9 Diguanylate cyclase CB0101_07440 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CB0101_07450 ENOG4105C0D helicase CB0101_07480 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) CB0101_07490 ENOG4105F2I Transposase CB0101_07495 ENOG4105CNW domain protein CB0101_07510 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CB0101_07515 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CB0101_07520 ENOG4105CXI aluminum resistance protein CB0101_07540 ENOG4105K9Q Binds to the 23S rRNA (By similarity) CB0101_07545 ENOG4105CDU Replicative dna helicase CB0101_07545 ENOG4105CDU Replicative dna helicase CB0101_07550 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CB0101_07585 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CB0101_07605 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CB0101_07615 ENOG4105EGS Mechanosensitive ion channel CB0101_07645 ENOG4105K63 Thioredoxin CB0101_07655 ENOG4105F2I Transposase CB0101_07735 ENOG4105DXN mazG family CB0101_07740 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) CB0101_07750 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CB0101_07755 ENOG4105CYW agmatinase CB0101_07770 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CB0101_07775 ENOG4105C9M aspartyl-trna synthetase CB0101_07780 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CB0101_07785 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CB0101_07790 ENOG4107U96 Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CB0101_07795 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CB0101_07815 ENOG4107QTZ amino acid CB0101_07820 ENOG4108IV0 ABC, transporter CB0101_07825 ENOG4105C0Z ABC transporter CB0101_07835 ENOG4105C32 Amino acid ABC transporter (Permease) CB0101_07840 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein CB0101_07845 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) CB0101_07855 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CB0101_07860 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) CB0101_07865 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CB0101_07870 ENOG4108YZ9 Urea amidohydrolase subunit gamma CB0101_07875 ENOG4105KI2 Urea amidohydrolase subunit beta CB0101_07880 ENOG4105CQM Urea amidohydrolase subunit alpha CB0101_07940 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CB0101_07950 ENOG4105TMB Formate nitrite transporter CB0101_07960 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) CB0101_07965 ENOG4107QYG anthranilate phosphoribosyltransferase CB0101_07980 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CB0101_07985 ENOG4107R3J Transporter CB0101_07990 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) CB0101_07995 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CB0101_08010 ENOG4108RIR Molybdenum cofactor biosynthesis protein CB0101_08020 ENOG4108ZAF Molybdopterin CB0101_08025 ENOG4105CVM Molybdenum cofactor synthesis domain protein CB0101_08030 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CB0101_08040 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CB0101_08045 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CB0101_08060 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CB0101_08070 ENOG4105CMQ Chloride channel CB0101_08105 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) CB0101_08110 ENOG4105CFG Acts as a chaperone (By similarity) CB0101_08125 ENOG41082BG Binds together with S18 to 16S ribosomal RNA (By similarity) CB0101_08135 ENOG4105CDH Citrulline--aspartate ligase CB0101_08150 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CB0101_08165 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR CB0101_08170 ENOG4108KGH TRANSCRIPTIONal CB0101_08175 ENOG4107STW synthase CB0101_08180 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CB0101_08195 ENOG4107UAN Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CB0101_08210 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CB0101_08215 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CB0101_08220 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CB0101_08225 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CB0101_08230 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CB0101_08240 ENOG4105C6E dna polymerase iii CB0101_08250 ENOG4105JFG SpoIID LytB domain protein CB0101_08255 ENOG41084A0 50s ribosomal protein L35 CB0101_08260 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CB0101_08275 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CB0101_08285 ENOG4105CMR udp-glucose 4-epimerase CB0101_08290 ENOG4105BZF Glycosyl transferase (Group 1 CB0101_08295 ENOG4105CJN penicillin-binding protein CB0101_08310 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CB0101_08315 ENOG4107VQD May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) CB0101_08385 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) CB0101_08390 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein CB0101_08395 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CB0101_08405 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CB0101_08415 ENOG4105DFU Cell wall formation (By similarity) CB0101_08420 ENOG4105D4A Cell wall formation (By similarity) CB0101_08425 ENOG41082EZ Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CB0101_08430 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CB0101_08440 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CB0101_08445 ENOG4107Z9D Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CB0101_08450 ENOG4107QHF type ii secretion system protein e CB0101_08455 ENOG4105CZX twitching motility protein CB0101_08475 ENOG4105CBX hi0933 family CB0101_08485 ENOG4105VFU Rna-binding protein CB0101_08490 ENOG4105CH7 arginosuccinase CB0101_08495 ENOG4107SGM protein serine threonine phosphatase CB0101_08505 ENOG4107Y1F Involved in the transcription termination process (By similarity) CB0101_08520 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CB0101_08610 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CB0101_08620 ENOG4105QNJ serralysin (EC 3.4.24.40) CB0101_08625 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii CB0101_08630 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase CB0101_08670 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CB0101_08675 ENOG4106YF5 Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna (By similarity) CB0101_08680 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CB0101_08695 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase CB0101_08710 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase CB0101_08755 ENOG4105IQ5 FAD linked oxidase domain protein CB0101_08780 ENOG4105C1B dTDP-glucose 4-6-dehydratase CB0101_08875 ENOG4105C42 Type I secretion membrane fusion protein (HlyD CB0101_08880 ENOG4108JJA ABC, transporter CB0101_08895 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CB0101_08920 ENOG4105F2I Transposase CB0101_08930 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CB0101_08940 ENOG4106CSM Rv0623-like transcription factor CB0101_08945 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CB0101_08965 ENOG4105EY8 ABC transporter CB0101_08975 ENOG4105D7W serine acetyltransferase CB0101_08980 ENOG4105XMH SpoVT AbrB domain protein CB0101_08985 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A CB0101_08990 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CB0101_09010 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CB0101_09015 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CB0101_09030 ENOG41086BQ Protein CrcB homolog CB0101_09035 ENOG4107KCI Protein CrcB homolog CB0101_09050 ENOG4105CJW magnesium transporter CB0101_09055 ENOG4105WVZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CB0101_09065 ENOG4105CEN a g-specific adenine glycosylase CB0101_09075 ENOG4105K8N protein family UPF0079, ATPase CB0101_09080 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) CB0101_09085 ENOG4107T5V SNARE associated Golgi CB0101_09090 ENOG41080E3 single-stranded DNA-binding protein CB0101_09100 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CB0101_09115 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CB0101_09120 ENOG4105CRK lysyL-tRNA synthetase CB0101_09145 ENOG41067HS methyltransferase CB0101_09200 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CB0101_09210 ENOG4105CV1 Transketolase (EC 2.2.1.1) CB0101_09220 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CB0101_09225 ENOG4108Z6M essential for photochemical activity. FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin. The C-terminus interacts with PsaA B D and helps assemble the protein into the PSI complex. Required for binding of PsaD and PsaE to PSI. PSI is a plastocyanin cytochrome c6- ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn CB0101_09240 ENOG41080P6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CB0101_09250 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CB0101_09280 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CB0101_09290 ENOG4107QRI Phosphoketolase CB0101_09320 ENOG4105EU8 FAD linked oxidase domain protein CB0101_09350 ENOG4105E5D amino acid CB0101_09355 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CB0101_09360 ENOG4108HMX isocitrate dehydrogenase (NADP) CB0101_09380 ENOG4105BZ1 (ABC) transporter CB0101_09385 ENOG4105BZ1 (ABC) transporter CB0101_09390 ENOG4107EF8 Glycosyl transferase (Group 1 CB0101_09420 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CB0101_09435 ENOG4105CMR udp-glucose 4-epimerase CB0101_09440 ENOG4105CUT histidyl-tRNA synthetase CB0101_09445 ENOG4105C6Y Udp-glucose 6-dehydrogenase CB0101_09460 ENOG4105YEU This protein is a component of the reaction center of photosystem II (By similarity) CB0101_09465 ENOG4107JBH Required for PSII activity (By similarity) CB0101_09470 ENOG410689D This b-type cytochrome is tightly associated with the reaction center of photosystem II and possibly is part of the water-oxidation complex (By similarity) CB0101_09475 ENOG4105NT3 This b-type cytochrome is tightly associated with the reaction center of photosystem II and possibly is part of the water-oxidation complex (By similarity) CB0101_09480 ENOG4107SP2 The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity CB0101_09485 ENOG410828V rubredoxin CB0101_09490 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CB0101_09505 ENOG4105CHW UPF0052 protein CB0101_09510 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CB0101_09520 ENOG4105EET magnesium chelatase CB0101_09545 ENOG4108YZ4 nudix hydrolase CB0101_09550 ENOG4105CVP deoxyribo-dipyrimidine photolyase CB0101_09575 ENOG4105CVP deoxyribo-dipyrimidine photolyase CB0101_09580 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH CB0101_09585 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CB0101_09605 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CB0101_09610 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CB0101_09620 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) CB0101_09625 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CB0101_09645 ENOG4105C37 (CBS) domain CB0101_09665 ENOG4106815 This protein is a component of the reaction center of photosystem II (By similarity) CB0101_09670 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CB0101_09675 ENOG4107Z12 Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) CB0101_09695 ENOG4105DC1 bifunctional purine biosynthesis protein purh CB0101_09710 ENOG4107RAJ Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CB0101_09715 ENOG4105PW4 Sugar fermentation stimulation protein homolog CB0101_09745 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CB0101_09750 ENOG4105ESV Glycosyl transferase, family 4 CB0101_09755 ENOG4105CEV competence damage-inducible protein CB0101_09760 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CB0101_09780 ENOG4107M19 This protein is a component of the reaction center of photosystem II (By similarity) CB0101_09790 ENOG410686T photosystem II reaction center protein N CB0101_09795 ENOG4105WIA photosystem II reaction center protein H CB0101_09800 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CB0101_09805 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CB0101_09820 ENOG4108R0D protein with myosin-like CB0101_09825 ENOG4107RU9 Transcriptional regulator, Crp Fnr family CB0101_09830 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CB0101_09835 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CB0101_09840 ENOG4105DHP deoxycytidine triphosphate deaminase CB0101_09850 ENOG4108S64 thioredoxin-like protein txlA CB0101_09865 ENOG4107SC1 transglycosylase CB0101_09875 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CB0101_09890 ENOG4107YD0 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CB0101_09915 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CB0101_09935 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CB0101_09940 ENOG4107W9I Creatinine amidohydrolase CB0101_09950 ENOG4108VX5 3-methyladenine DNA glycosylase CB0101_10010 ENOG4105NI8 Cytosine-specific methyltransferase CB0101_10020 ENOG4108VX5 3-methyladenine DNA glycosylase CB0101_10025 ENOG4105CXT aspartate transcarbamylase CB0101_10065 ENOG4105CPJ photosystem II manganese-stabilizing CB0101_10070 ENOG4107RIQ Sulfate adenylate transferase CB0101_10090 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CB0101_10095 ENOG4105CSM endonuclease III CB0101_10100 ENOG4105EY5 This is one of the two reaction center proteins of photosystem II CB0101_10105 ENOG4105DF7 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) CB0101_10110 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CB0101_10115 ENOG4105JJR Histidine kinase CB0101_10120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CB0101_10130 ENOG4105J3Z Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) CB0101_10135 ENOG4107QSS Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity) CB0101_10150 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CB0101_10160 ENOG4105CQC Prephenate dehydratase CB0101_10170 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CB0101_10175 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) CB0101_10180 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CB0101_10185 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CB0101_10190 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CB0101_10195 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) CB0101_10220 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CB0101_10230 ENOG4105E4R Precorrin-3B C17-methyltransferase CB0101_10240 ENOG4105MN0 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 CB0101_10245 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 CB0101_10250 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CB0101_10255 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CB0101_10260 ENOG4105C79 DNA protecting protein DprA CB0101_10285 ENOG4105YVZ photosystem II CB0101_10295 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CB0101_10300 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CB0101_10305 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CB0101_10310 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CB0101_10315 ENOG4107S5T Carbohydrate kinase CB0101_10345 ENOG4106BTU phycobilisome rod-core linker polypeptide CB0101_10365 ENOG4108RIN C-phycoerythrin class I beta chain CB0101_10370 ENOG4108SDR phycocyanin, alpha subunit CB0101_10380 ENOG4108RIN C-phycoerythrin class I beta chain CB0101_10385 ENOG4108SDR phycocyanin, alpha subunit CB0101_10405 ENOG4105CAT Cytidine monophosphate kinase CB0101_10415 ENOG4105CXB phosphoribosylaminoimidazole synthetase CB0101_10465 ENOG4105EXC Acyl-transferase CB0101_10485 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) CB0101_10505 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) CB0101_10515 ENOG4105CNI cell division protein FtsW CB0101_10535 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) CB0101_10540 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) CB0101_10555 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CB0101_10560 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CB0101_10580 ENOG4106D5S Corrinoid adenosyltransferase BtuR CobO CobP CB0101_10645 ENOG4105CD2 stage iii sporulation protein aa CB0101_10655 ENOG4108USA electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity) CB0101_10660 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CB0101_10665 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CB0101_10670 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CB0101_10675 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CB0101_10680 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CB0101_10685 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CB0101_10690 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CB0101_10695 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CB0101_10700 ENOG410848H 50s ribosomal protein l29 CB0101_10705 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CB0101_10710 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CB0101_10715 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) CB0101_10720 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CB0101_10725 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CB0101_10730 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CB0101_10735 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CB0101_10740 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CB0101_10745 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CB0101_10750 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CB0101_10755 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CB0101_10760 ENOG41067V7 50S ribosomal protein L36 CB0101_10765 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CB0101_10770 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CB0101_10775 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CB0101_10780 ENOG4108ZT0 50S ribosomal protein l17 CB0101_10785 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CB0101_10790 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CB0101_10795 ENOG4108UJD 30S ribosomal protein S9 CB0101_10800 ENOG41082HT Binds the 23S rRNA (By similarity) CB0101_10805 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CB0101_10815 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CB0101_10835 ENOG4108JJA ABC, transporter CB0101_10840 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CB0101_10845 ENOG4105BZU Histidine kinase CB0101_10860 ENOG4105JHY Membrane CB0101_10865 ENOG4105CKK Glycosyl transferase, family 2 CB0101_10880 ENOG4108W6I photosystem I reaction center protein subunit XI CB0101_10920 ENOG4108PWY Carbohydrate-selective porin OprB CB0101_10925 ENOG4108PWY Carbohydrate-selective porin OprB CB0101_10930 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CB0101_10935 ENOG4105X1F electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity) CB0101_10980 ENOG4105CVN desaturase CB0101_10995 ENOG4108DIF synthase (EC 4.2.1.75) CB0101_11000 ENOG4107TVC Glycosyl transferase, family 2 CB0101_11010 ENOG41082QS Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CB0101_11020 ENOG4107MKT Stringent starvation protein a CB0101_11035 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CB0101_11080 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) CB0101_11085 ENOG4105CVB Vitamin K epoxide reductase CB0101_11090 ENOG4108IYU L-aspartate oxidase CB0101_11095 ENOG41060KK Stabilizes the structure of photosystem II oxygen- evolving complex (OEC), the ion environment of oxygen evolution and protects the OEC against heat-induced inactivation (By similarity) CB0101_11105 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CB0101_11125 ENOG4105ECY inositol monophosphatase CB0101_11160 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) CB0101_11165 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CB0101_11170 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CB0101_11175 ENOG4105WN2 Stabilizes the interaction between PsaC and the PSI core, assists the docking of the ferredoxin to PSI and interacts with ferredoxin-NADP oxidoreductase (By similarity) CB0101_11185 ENOG4105C9U ATP-dependent DNA helicase RecQ CB0101_11190 ENOG41068JE domain protein CB0101_11195 ENOG4105C26 Dehydrogenase CB0101_11205 ENOG4105BZU Histidine kinase CB0101_11225 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CB0101_11295 ENOG4105ETX regulatoR CB0101_11300 ENOG4105BZU Histidine kinase CB0101_11390 ENOG41084W5 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CB0101_11405 ENOG4105WH1 Two component transcriptional regulator luxr family CB0101_11545 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CB0101_11550 ENOG4107U45 Cobalt transport protein CB0101_11565 ENOG41080W8 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CB0101_11575 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CB0101_11615 ENOG4105K70 DNA-binding protein CB0101_11650 ENOG4105D52 delta-aminolevulinic acid dehydratase CB0101_11675 ENOG4105DJY efflux transporter, rnd family, mfp subunit CB0101_11690 ENOG4108IJ9 (ABC) transporter CB0101_11695 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CB0101_11710 ENOG4105C5H ABC transporter CB0101_11735 ENOG4105F2I Transposase CB0101_11750 ENOG4108Q6X Aspartoacylase (EC 3.5.1.15) CB0101_11910 ENOG4105F2I Transposase CB0101_12020 ENOG41084W5 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CB0101_12110 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CB0101_12125 ENOG41080W8 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CB0101_12195 ENOG4108PWY Carbohydrate-selective porin OprB CB0101_12230 ENOG4105F2I Transposase CB0101_12310 ENOG41076WT Manganese-binding polypeptide with L-arginine metabolizing enzyme activity. Component of the core of photosystem II (By similarity) CB0101_12330 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) CB0101_12350 ENOG4106FC9 Protein of unknown function (DUF3018) CB0101_12355 ENOG4105NFY transcriptional modulator of maze toxin, mazf CB0101_12400 ENOG4108HRK Histidine kinase CB0101_12490 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) CB0101_12510 ENOG4105DSY exodeoxyribonuclease V, gamma CB0101_12515 ENOG4107QKA exodeoxyribonuclease V beta CB0101_12520 ENOG4107QYX exodeoxyribonuclease v alpha CB0101_12525 ENOG4107QYX exodeoxyribonuclease v alpha CB0101_12530 ENOG4105CJT Mannose-1-phosphate guanylyltransferase CB0101_12535 ENOG4105C1J atp-dependent rna helicase CB0101_12545 ENOG4105VFU Rna-binding protein CB0101_12560 ENOG4105BZ1 (ABC) transporter CB0101_12575 ENOG4108302 MgtC SapB transporter CB0101_12630 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CB0101_12635 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CB0101_12650 ENOG4105C72 UPF0176 protein CB0101_12655 ENOG4107QSQ Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CB0101_12660 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CB0101_12665 ENOG4105C8B TIGR00159 family CB0101_12750 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CB0101_12785 ENOG4105WVZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CB0101_12805 ENOG4106I2R Coenzyme F420 hydrogenase dehydrogenase, beta CB0101_12820 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CB0101_12845 ENOG4105BZU Histidine kinase CB0101_12865 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CB0101_12870 ENOG4107RNI Glucose 6-phosphate dehydrogenase effector OpcA CB0101_12875 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CB0101_12880 ENOG4108ZM9 phosphoglycerate mutase CB0101_12885 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 CB0101_12895 ENOG4107QYX exodeoxyribonuclease v alpha CB0101_12925 ENOG4105W3H MtN3 and saliva related transmembrane protein CB0101_12930 ENOG4105D3G Pseudouridine synthase CB0101_12945 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CB0101_12985 ENOG4105DRS transport system, permease CB0101_12990 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CB0101_13000 ENOG4107RFW hydrolase family 57 CB0101_13010 ENOG4108JT6 LycopEne CB0101_13030 ENOG4107QVP Dehydrogenase CB0101_13035 ENOG4105K63 Thioredoxin CB0101_13040 ENOG4108URH decarboxylase CB0101_13045 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CB0101_13050 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CB0101_13055 ENOG4106ASF Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. PetG is required for either the stability or assembly of the cytochrome b6-f complex (By similarity) CB0101_13065 ENOG4106FVC RNA methyltransferase CB0101_13085 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) CB0101_13120 ENOG4105DEF Extracellular solute-binding protein, family 5 CB0101_13125 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CB0101_13130 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CB0101_13145 ENOG4105C3G gtp-binding protein CB0101_13160 ENOG4105CZX twitching motility protein CB0101_13165 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CB0101_13170 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CB0101_13180 ENOG4106AST May help in the organization of the PsaE and PsaF subunits (By similarity) CB0101_13185 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CB0101_13190 ENOG4105F23 Fibronectin-binding protein CB0101_13205 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CB0101_13210 ENOG4105D1D Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CB0101_13220 ENOG4105CIA precorrin-4 C(11)-methyltransferase CB0101_13235 ENOG4105C9X ppx gppa phosphatase CB0101_13250 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CB0101_13260 ENOG4107ZYR domain protein CB0101_13275 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CB0101_13285 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) CB0101_13305 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CB0101_13340 ENOG4108R6K riboflavin synthase, subunit alpha CB0101_13360 ENOG4108K7V UPF0284 protein CB0101_13375 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CB0101_13385 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CB0101_13390 ENOG4105DR5 peptidase CB0101_13395 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CB0101_13400 ENOG4105CHM Aminotransferase CB0101_13405 ENOG4105K63 Thioredoxin CB0101_13415 ENOG4105D64 Mechanosensitive ion channel CB0101_13430 ENOG4105Q84 sucrose synthase CB0101_13445 ENOG4105KHN chorismate mutase CB0101_13460 ENOG4105UVI RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) CB0101_13470 ENOG4107RIX inner membrane protein translocase component YidC CB0101_13545 ENOG4105F2I Transposase CB0101_13550 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CB0101_13555 ENOG4105C3J Cysteine desulfurase CB0101_13560 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CB0101_13570 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) CB0101_13585 ENOG4105DK0 Indole-3-glycerol phosphate synthase CB0101_13610 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CB0101_13615 ENOG4105C8Y Acetylornithine aminotransferase CB0101_13620 ENOG4105C8Y Acetylornithine aminotransferase CB0101_13660 ENOG4105DTQ mandelate racemase muconate lactonizing CB0101_13665 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CB0101_13670 ENOG4105CPF Cell wall formation (By similarity) CB0101_13695 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CB0101_13710 ENOG41084IE Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CB0101_13715 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CB0101_13720 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CB0101_13730 ENOG4105D3Q Sugar transferase CB0101_13735 ENOG4105CPK Glycosyl transferase (Group 1 CB0101_13765 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit CB0101_13770 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) CB0101_13780 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CB0101_13790 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase CB0101_13795 ENOG4108JQC penicillin-binding protein 1A CB0101_13805 ENOG41080UX Methyltransferase CB0101_13810 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase CB0101_13830 ENOG4105ETX regulatoR CB0101_13845 ENOG4105BZU Histidine kinase CB0101_13855 ENOG4105F2I Transposase CB0101_13880 ENOG4106855 Competence protein CB0101_13925 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CB0101_13930 ENOG410814C multidrug resistance protein CB0101_13935 ENOG41083MR nifu domain-containing protein CB0101_13940 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CB0101_13945 ENOG4105DWT malate dehydrogenase (quinone) CB0101_13950 ENOG4105DZP Membrane-associated zinc metalloprotease CB0101_13955 ENOG41082AF Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CB0101_13960 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CB0101_13965 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase CB0101_14035 ENOG4105CVB Vitamin K epoxide reductase CB0101_14045 ENOG41082CH UPF0145 protein CB0101_14065 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) CB0101_14090 ENOG4105E0X reductase CB0101_14105 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CB0101_14115 ENOG4106AG1 Involved in the binding and or turnover of quinones at the Q(B) site of Photosystem II (By similarity) CB0101_14145 ENOG4107YU2 histidine triad (hIT) protein CB0101_14150 ENOG4105C0P Mg chelatase subunit ChlI CB0101_14155 ENOG410848W 30S ribosomal protein S21 CB0101_14170 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CB0101_14190 ENOG4107W7X Aldolase CB0101_14195 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CB0101_14215 ENOG4107QVI Methyltransferase, type 11 CB0101_14265 ENOG4108P5B Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) CB0101_14270 ENOG4106BTU phycobilisome rod-core linker polypeptide CB0101_14285 ENOG4107RDJ Sulfotransferase CB0101_14295 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 CB0101_14310 ENOG4105BZS acriflavin resistance protein CB0101_14320 ENOG4105BZS acriflavin resistance protein CB0101_14330 ENOG4105D1H recombination factor protein RarA CB0101_14355 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CB0101_14360 ENOG4107ZH9 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) CB0101_14365 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CB0101_14380 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CB0101_14390 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) CB0101_14400 ENOG4105C5H ABC transporter CB0101_14410 ENOG4105C0H protease CB0101_14425 ENOG4105CQ7 ATP-dependent helicase CB0101_14445 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CB0101_14500 ENOG4108R6B Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CB0101_14505 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CB0101_14510 ENOG4105CN1 protease CB0101_14515 ENOG4105DCI Phosphohydrolase CB0101_14520 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) CB0101_14545 ENOG41083CN Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) CB0101_14570 ENOG4105D6H One of the two reaction center proteins of photosystem II (PSII), D2 is needed for assembly of a stable PSII complex (By similarity) CB0101_14575 ENOG4105VUV UPF0367 protein CB0101_14580 ENOG4108JJB ABC transporter CB0101_14595 ENOG4105FA2 dna polymerase iii CB0101_14600 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CB0101_14605 ENOG4105C59 p-type ATPase CB0101_14610 ENOG4108PPB Seems to be required for the assembly of the photosystem I complex (By similarity) CB0101_14620 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CB0101_14625 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) CB0101_14630 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CB0101_14650 ENOG41072GX Peptidase M22 Glycoprotease CB0101_14665 ENOG4105VFU Rna-binding protein CB0101_14675 ENOG4105FE1 phytoene synthase CB0101_14680 ENOG4105CVN desaturase CB0101_14685 ENOG4105GHY electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity) CB0101_14695 ENOG4105DUM transcriptional regulator, lysR family CB0101_14715 ENOG4105C8S subunit m CB0101_14740 ENOG4108Q9V regulatoR CB0101_14750 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CB0101_14755 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CB0101_14765 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CB0101_14770 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) CB0101_14790 ENOG41082J7 Rhodanese domain protein CB0101_14795 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) CB0101_14800 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CB0101_14815 ENOG4105DZP Membrane-associated zinc metalloprotease CB0101_14820 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CB0101_14840 ENOG4105CE4 GlcNAc 6-P deacetylase CB0101_14860 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CB0101_14870 ENOG4105C3J Cysteine desulfurase CB0101_14885 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CB0101_14890 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CB0101_14900 ENOG4105WGP Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl- CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis (By similarity) CB0101_14910 ENOG4105CEY Amp-dependent synthetase and ligase CB0101_14930 ENOG4105EYW Ion transport protein CB0101_14935 ENOG4105D7Z glutathione synthase CB0101_14965 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CB0101_14975 ENOG4105DDQ anthranilate synthase CB0101_14985 ENOG4105CIH Imidazole acetol-phosphate transaminase CB0101_14990 ENOG4105C75 arginyL-tRNA synthetase CB0101_14995 ENOG4107TPY serine threonine protein kinase CB0101_15015 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CB0101_15025 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) CB0101_15045 ENOG4108JQ6 ABC transporter CB0101_15055 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CB0101_15065 ENOG4105BZA Phosphoglycerate kinase CB0101_15075 ENOG4105E0F Histidine kinase CB0101_15080 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CB0101_15090 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CB0101_15100 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CB0101_15105 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CB0101_15115 ENOG4105GVR general secretion pathway protein D