locus-tag	class	description
CB0101_00005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CB0101_00055	COG2010	Cytochrome c
CB0101_00075	COG0159	tryptophan synthase activity
CB0101_00110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CB0101_00115	COG1845	cytochrome c oxidase, subunit III
CB0101_00215	COG1840	ABC-type Fe3 transport system, periplasmic component
CB0101_00235	COG0730	response to heat
CB0101_00240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CB0101_00275	COG2267	carboxylic ester hydrolase activity
CB0101_00295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CB0101_00310	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CB0101_00325	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CB0101_00345	COG3604	Transcriptional regulator
CB0101_00375	COG2226	methyltransferase
CB0101_00390	COG0351	phosphomethylpyrimidine kinase
CB0101_00410	COG0367	asparagine synthase
CB0101_00415	COG0540	Belongs to the ATCase OTCase family
CB0101_00440	COG0028	Belongs to the TPP enzyme family
CB0101_00445	COG3527	Alpha-acetolactate decarboxylase
CB0101_00460	COG1228	amidohydrolase
CB0101_00475	COG0477	Major facilitator Superfamily
CB0101_00480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CB0101_00505	COG2226	methyltransferase
CB0101_00515	COG3039	Transposase
CB0101_00545	COG2326	polyphosphate kinase activity
CB0101_00565	COG0745	RESPONSE REGULATOR receiver
CB0101_00680	COG1215	transferase activity, transferring glycosyl groups
CB0101_00690	COG3706	GGDEF domain
CB0101_00785	COG3039	Transposase
CB0101_00815	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CB0101_00860	COG0659	secondary active sulfate transmembrane transporter activity
CB0101_00910	COG0799	negative regulation of ribosome biogenesis
CB0101_00920	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CB0101_00930	COG1115	amino acid carrier protein
CB0101_00950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CB0101_00955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CB0101_01000	COG0237	dephospho-CoA kinase activity
CB0101_01010	COG0418	dihydroorotase activity
CB0101_01015	COG1872	DUF167
CB0101_01020	COG5001	Diguanylate cyclase
CB0101_01020	COG1716	ATPase activity
CB0101_01075	COG0709	Synthesizes selenophosphate from selenide and ATP
CB0101_01085	COG2197	response regulator
CB0101_01155	COG0640	Transcriptional regulator
CB0101_01160	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CB0101_01170	COG0745	RESPONSE REGULATOR receiver
CB0101_01175	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CB0101_01180	COG0573	inorganic phosphate transmembrane transporter activity
CB0101_01185	COG0581	inorganic phosphate transmembrane transporter activity
CB0101_01190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CB0101_01200	COG3039	Transposase
CB0101_01225	COG0671	phosphoesterase, PA-phosphatase related
CB0101_01230	COG1252	NADH dehydrogenase
CB0101_01235	COG2271	Major facilitator Superfamily
CB0101_01240	COG0058	SHG alpha-glucan phosphorylase activity
CB0101_01245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CB0101_01270	COG0598	Magnesium transport protein CorA
CB0101_01290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CB0101_01295	COG5002	protein histidine kinase activity
CB0101_01300	COG0745	RESPONSE REGULATOR receiver
CB0101_01325	COG1741	Belongs to the pirin family
CB0101_01345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CB0101_01360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CB0101_01370	COG1132	(ABC) transporter
CB0101_01380	COG0149	triose-phosphate isomerase activity
CB0101_01385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CB0101_01390	COG5001	Diguanylate cyclase
CB0101_01395	COG1215	transferase activity, transferring glycosyl groups
CB0101_01410	COG1429	ligase activity, forming nitrogen-metal bonds
CB0101_01415	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CB0101_01425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CB0101_01440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CB0101_01500	COG4106	trans-aconitate 2-methyltransferase activity
CB0101_01505	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CB0101_01520	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CB0101_01525	COG1122	ATPase activity
CB0101_01535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CB0101_01545	COG1836	PFAM Integral membrane protein DUF92
CB0101_01560	COG3639	organic phosphonate transmembrane transporter activity
CB0101_01565	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CB0101_01575	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CB0101_01580	COG0436	Aminotransferase
CB0101_01590	COG1573	uracil-dna glycosylase
CB0101_01595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CB0101_01600	COG0793	Belongs to the peptidase S41A family
CB0101_01610	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CB0101_01630	COG0861	Integral membrane protein TerC family
CB0101_01645	COG0513	Belongs to the DEAD box helicase family
CB0101_01655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CB0101_01665	COG0312	modulator of DNA gyrase
CB0101_01670	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CB0101_01685	COG0163	prenyltransferase activity
CB0101_01690	COG0557	exoribonuclease II activity
CB0101_01700	COG2119	membrane
CB0101_01715	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CB0101_01715	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CB0101_01720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CB0101_01730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CB0101_01730	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CB0101_01735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CB0101_01740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CB0101_01750	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CB0101_01755	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CB0101_01765	COG0191	fructose-bisphosphate aldolase activity
CB0101_01770	COG0673	inositol 2-dehydrogenase activity
CB0101_01780	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CB0101_01785	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CB0101_01795	COG3954	Phosphoribulokinase
CB0101_01800	COG0473	3-isopropylmalate dehydrogenase activity
CB0101_01805	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CB0101_01810	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CB0101_01825	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CB0101_01850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CB0101_01860	COG0114	fumarate hydratase activity
CB0101_01865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CB0101_01870	COG2197	response regulator
CB0101_01880	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CB0101_01895	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CB0101_01915	COG0625	glutathione transferase activity
CB0101_01955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CB0101_01990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CB0101_02015	COG2124	cytochrome p450
CB0101_02050	COG1970	mechanosensitive ion channel activity
CB0101_02085	COG3631	Ketosteroid isomerase-related protein
CB0101_02090	COG0724	RNA recognition motif
CB0101_02100	COG0058	SHG alpha-glucan phosphorylase activity
CB0101_02130	COG0281	malic enzyme
CB0101_02170	COG1201	RNA secondary structure unwinding
CB0101_02175	COG1793	dna ligase
CB0101_02185	COG3588	fructose-bisphosphate aldolase
CB0101_02220	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CB0101_02225	COG0514	ATP-dependent DNA helicase (RecQ)
CB0101_02235	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CB0101_02265	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CB0101_02280	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CB0101_02295	COG0740	serine-type endopeptidase activity
CB0101_02320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CB0101_02330	COG0577	efflux transmembrane transporter activity
CB0101_02330	COG1136	(ABC) transporter
CB0101_02335	COG0469	pyruvate kinase activity
CB0101_02360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CB0101_02365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CB0101_02435	COG0284	orotidine-5'-phosphate decarboxylase activity
CB0101_02435	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CB0101_02515	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CB0101_02520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CB0101_02530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CB0101_02535	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CB0101_02570	COG1653	transport
CB0101_02575	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CB0101_02600	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CB0101_02605	COG0483	inositol monophosphate 1-phosphatase activity
CB0101_02620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CB0101_02625	COG0581	inorganic phosphate transmembrane transporter activity
CB0101_02630	COG0573	inorganic phosphate transmembrane transporter activity
CB0101_02640	COG0484	heat shock protein binding
CB0101_02650	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CB0101_02655	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CB0101_02660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CB0101_02665	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CB0101_02665	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CB0101_02670	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CB0101_02675	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CB0101_02700	COG0166	Belongs to the GPI family
CB0101_02705	COG0495	leucyl-tRNA aminoacylation
CB0101_02715	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CB0101_02720	COG1104	cysteine desulfurase activity
CB0101_02745	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CB0101_02750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CB0101_02750	COG0426	domain, Protein
CB0101_02755	COG0322	excinuclease ABC activity
CB0101_02765	COG3046	protein related to deoxyribodipyrimidine photolyase
CB0101_02780	COG0587	DNA-directed DNA polymerase activity
CB0101_02795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CB0101_02800	COG0646	methionine synthase
CB0101_02800	COG1410	methionine synthase
CB0101_02820	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CB0101_02830	COG2385	sporulation resulting in formation of a cellular spore
CB0101_02870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CB0101_02875	COG0072	phenylalanine-tRNA ligase activity
CB0101_02880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CB0101_02885	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CB0101_02890	COG0557	exoribonuclease II activity
CB0101_02910	COG1028	Short-chain dehydrogenase reductase Sdr
CB0101_02920	COG3263	regulation of cellular component size
CB0101_02945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CB0101_02980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CB0101_03000	COG1115	amino acid carrier protein
CB0101_03050	COG1064	alcohol dehydrogenase
CB0101_03080	COG0450	alkyl hydroperoxide reductase
CB0101_03085	COG1619	proteins homologs of microcin C7 resistance protein MccF
CB0101_03090	COG0047	phosphoribosylformylglycinamidine synthase activity
CB0101_03095	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CB0101_03120	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CB0101_03130	COG0129	dihydroxy-acid dehydratase activity
CB0101_03150	COG0363	glucosamine-6-phosphate deaminase activity
CB0101_03155	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CB0101_03160	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CB0101_03165	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CB0101_03170	COG1494	fructose-1,6-bisphosphatase
CB0101_03175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CB0101_03180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CB0101_03190	COG1137	ATPase activity
CB0101_03220	COG0644	oxidoreductase
CB0101_03230	COG0751	glycine-tRNA ligase activity
CB0101_03235	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CB0101_03240	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CB0101_03245	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CB0101_03255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CB0101_03260	COG0052	Belongs to the universal ribosomal protein uS2 family
CB0101_03265	COG1216	Glycosyl transferase, family 2
CB0101_03275	COG1136	(ABC) transporter
CB0101_03285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CB0101_03295	COG0612	Peptidase, M16
CB0101_03315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CB0101_03320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CB0101_03325	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CB0101_03340	COG0590	tRNA wobble adenosine to inosine editing
CB0101_03345	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CB0101_03355	COG0174	glutamine synthetase
CB0101_03385	COG0515	serine threonine protein kinase
CB0101_03390	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CB0101_03395	COG3310	Protein conserved in bacteria
CB0101_03415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CB0101_03420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CB0101_03425	COG0022	dehydrogenase e1 component
CB0101_03435	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CB0101_03440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CB0101_03475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CB0101_03490	COG0358	DNA primase activity
CB0101_03505	COG0632	four-way junction helicase activity
CB0101_03510	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CB0101_03520	COG0587	DNA-directed DNA polymerase activity
CB0101_03525	COG0154	amidase activity
CB0101_03535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CB0101_03540	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CB0101_03550	COG0505	Belongs to the CarA family
CB0101_03555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CB0101_03565	COG1132	(ABC) transporter
CB0101_03575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CB0101_03605	COG2176	DNA-directed DNA polymerase activity
CB0101_03610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CB0101_03620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CB0101_03625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CB0101_03630	COG0142	geranyltranstransferase activity
CB0101_03635	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CB0101_03640	COG0860	N-Acetylmuramoyl-L-alanine amidase
CB0101_03645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CB0101_03650	COG2045	Belongs to the ComB family
CB0101_03655	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CB0101_03665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CB0101_03670	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CB0101_03670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CB0101_03675	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CB0101_03680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CB0101_03690	COG0297	glycogen (starch) synthase activity
CB0101_03695	COG1376	ErfK ybiS ycfS ynhG family protein
CB0101_03700	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CB0101_03705	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CB0101_03710	COG0681	Belongs to the peptidase S26 family
CB0101_03725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CB0101_03730	COG1121	(ABC) transporter
CB0101_03735	COG0803	Belongs to the bacterial solute-binding protein 9 family
CB0101_03780	COG1230	cation diffusion facilitator family transporter
CB0101_03795	COG0180	Tryptophanyl-tRNA synthetase
CB0101_03810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CB0101_03815	COG0837	glucose binding
CB0101_03820	COG0083	homoserine kinase activity
CB0101_03825	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CB0101_03830	COG0339	signal peptide processing
CB0101_03865	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CB0101_03870	COG1940	carbohydrate kinase activity
CB0101_03905	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CB0101_03910	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CB0101_03920	COG2010	Cytochrome c
CB0101_03950	COG0542	response to heat
CB0101_03975	COG0432	Pfam Uncharacterised protein family UPF0047
CB0101_04025	COG0181	hydroxymethylbilane synthase activity
CB0101_04045	COG1216	Glycosyl transferase, family 2
CB0101_04050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CB0101_04055	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CB0101_04065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CB0101_04080	COG0629	single-stranded DNA binding
CB0101_04085	COG2099	Precorrin-6x reductase
CB0101_04095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CB0101_04100	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CB0101_04110	COG0442	prolyl-tRNA aminoacylation
CB0101_04120	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CB0101_04145	COG0681	Belongs to the peptidase S26 family
CB0101_04150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CB0101_04170	COG0768	penicillin binding
CB0101_04175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CB0101_04190	COG0233	cytoplasmic translational termination
CB0101_04195	COG0528	UMP kinase activity
CB0101_04210	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CB0101_04245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CB0101_04245	COG0574	Belongs to the PEP-utilizing enzyme family
CB0101_04260	COG1034	ATP synthesis coupled electron transport
CB0101_04265	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CB0101_04270	COG3259	Nickel-dependent hydrogenase
CB0101_04280	COG0375	protein maturation
CB0101_04285	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CB0101_04290	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CB0101_04295	COG0298	carbon dioxide binding
CB0101_04315	COG0309	Hydrogenase expression formation protein (HypE)
CB0101_04385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CB0101_04400	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CB0101_04435	COG0071	Belongs to the small heat shock protein (HSP20) family
CB0101_04465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CB0101_04470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CB0101_04475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CB0101_04500	COG2059	Chromate
CB0101_04515	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CB0101_04525	COG0415	Belongs to the DNA photolyase family
CB0101_04540	COG0539	negative regulation of cytoplasmic translation
CB0101_04550	COG3396	Phenylacetate-CoA oxygenase
CB0101_04555	COG5322	oxidoreductase activity
CB0101_04560	COG0825	malonyl-CoA metabolic process
CB0101_04570	COG0302	gtp cyclohydrolase
CB0101_04580	COG0135	phosphoribosylanthranilate isomerase activity
CB0101_04585	COG0517	IMP dehydrogenase activity
CB0101_04585	COG1994	Peptidase M50
CB0101_04590	COG0095	Lipoate-protein ligase
CB0101_04625	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CB0101_04630	COG1228	amidohydrolase
CB0101_04635	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CB0101_04640	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CB0101_04645	COG0569	domain protein
CB0101_04650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CB0101_04655	COG1253	flavin adenine dinucleotide binding
CB0101_04665	COG3273	potassium ion transport
CB0101_04665	COG0471	metal ion transport
CB0101_04670	COG1959	2 iron, 2 sulfur cluster binding
CB0101_04675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CB0101_04685	COG0004	ammonium transporteR
CB0101_04715	COG0475	glutathione-regulated potassium exporter activity
CB0101_04720	COG1006	Multisubunit Na H antiporter MnhC subunit
CB0101_04725	COG0651	ATP synthesis coupled electron transport
CB0101_04755	COG0659	secondary active sulfate transmembrane transporter activity
CB0101_04765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CB0101_04780	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CB0101_04790	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CB0101_04800	COG0531	amino acid
CB0101_04825	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CB0101_04845	COG1850	ribulose-bisphosphate carboxylase activity
CB0101_04850	COG4451	ribulose bisphosphate carboxylase, small
CB0101_04885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CB0101_04890	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CB0101_04905	COG0464	growth
CB0101_04915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CB0101_04925	COG3781	membrane
CB0101_04935	COG2199	diguanylate cyclase activity
CB0101_04935	COG2200	EAL domain
CB0101_04940	COG0456	acetyltransferase
CB0101_04950	COG1132	(ABC) transporter
CB0101_04955	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CB0101_04960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CB0101_04965	COG3842	ATPase activity
CB0101_04970	COG0251	oxidation-reduction process
CB0101_04980	COG4942	peptidase
CB0101_05080	COG0545	Peptidyl-prolyl cis-trans isomerase
CB0101_05105	COG1525	nuclease
CB0101_05155	COG0662	Cupin 2, conserved barrel domain protein
CB0101_05155	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CB0101_05180	COG0463	Glycosyl transferase, family 2
CB0101_05190	COG1216	Glycosyl transferase, family 2
CB0101_05190	COG0438	transferase activity, transferring glycosyl groups
CB0101_05195	COG0438	transferase activity, transferring glycosyl groups
CB0101_05205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CB0101_05235	COG4423	Transcription factor
CB0101_05250	COG0297	glycogen (starch) synthase activity
CB0101_05275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CB0101_05290	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CB0101_05320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CB0101_05330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CB0101_05345	COG2801	Transposase and inactivated derivatives
CB0101_05365	COG3039	Transposase
CB0101_05375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CB0101_05390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CB0101_05395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CB0101_05400	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CB0101_05460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CB0101_05465	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CB0101_05465	COG0140	phosphoribosyl-ATP diphosphatase activity
CB0101_05480	COG0701	Predicted permease
CB0101_05505	COG1121	(ABC) transporter
CB0101_05510	COG3659	wide pore channel activity
CB0101_05520	COG1528	Iron-storage protein
CB0101_05525	COG0783	Belongs to the Dps family
CB0101_05535	COG0523	cobalamin synthesis protein
CB0101_05545	COG0735	belongs to the Fur family
CB0101_05555	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CB0101_05580	COG0708	Exodeoxyribonuclease III
CB0101_05585	COG0277	FAD linked oxidase domain protein
CB0101_05590	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CB0101_05600	COG0559	Belongs to the binding-protein-dependent transport system permease family
CB0101_05610	COG0411	ABC transporter
CB0101_05630	COG0405	Gamma-glutamyltransferase
CB0101_05645	COG1666	GTP binding
CB0101_05670	COG0857	belongs to the CobB CobQ family
CB0101_05680	COG3000	fatty acid hydroxylase
CB0101_05680	COG0300	oxidoreductase activity
CB0101_05685	COG0024	Methionine aminopeptidase
CB0101_05695	COG0335	large ribosomal subunit rRNA binding
CB0101_05715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CB0101_05745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CB0101_05745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CB0101_05750	COG0215	cysteine-tRNA ligase activity
CB0101_05760	COG0733	neurotransmitter:sodium symporter activity
CB0101_05775	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CB0101_05790	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CB0101_05800	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CB0101_05815	COG0492	ferredoxin-NADP+ reductase activity
CB0101_05825	COG1187	pseudouridine synthase activity
CB0101_05855	COG0440	acetolactate synthase activity
CB0101_05860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CB0101_05930	COG2361	Protein of unknown function DUF86
CB0101_05940	COG0424	maF-like protein
CB0101_05950	COG1492	cobalamin metabolic process
CB0101_05970	COG0482	sulfurtransferase activity
CB0101_05975	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CB0101_05975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CB0101_05980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CB0101_06060	COG0123	including yeast histone deacetylase and acetoin utilization protein
CB0101_06065	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CB0101_06075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CB0101_06080	COG0228	four-way junction DNA binding
CB0101_06085	COG1702	phosphate starvation-inducible protein PhoH
CB0101_06090	COG0670	Belongs to the BI1 family
CB0101_06100	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CB0101_06110	COG0336	Belongs to the RNA methyltransferase TrmD family
CB0101_06115	COG0330	HflC and HflK could
CB0101_06125	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CB0101_06135	COG1691	(AIR) carboxylase
CB0101_06155	COG0352	thiamine-phosphate diphosphorylase activity
CB0101_06160	COG0196	riboflavin kinase activity
CB0101_06170	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CB0101_06175	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CB0101_06180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CB0101_06185	COG0745	RESPONSE REGULATOR receiver
CB0101_06210	COG0641	radical SAM
CB0101_06215	COG0628	permease
CB0101_06245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CB0101_06245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CB0101_06255	COG2135	peptidase activity
CB0101_06260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CB0101_06265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CB0101_06275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CB0101_06350	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CB0101_06365	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CB0101_06375	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CB0101_06380	COG0508	dehydrogenase complex catalyzes the overall conversion of
CB0101_06390	COG1022	Amp-dependent synthetase and ligase
CB0101_06395	COG0321	lipoyl(octanoyl) transferase activity
CB0101_06400	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CB0101_06405	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CB0101_06420	COG0438	transferase activity, transferring glycosyl groups
CB0101_06425	COG0284	orotidine-5'-phosphate decarboxylase activity
CB0101_06435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CB0101_06475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CB0101_06490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CB0101_06505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CB0101_06515	COG0151	Belongs to the GarS family
CB0101_06520	COG5002	protein histidine kinase activity
CB0101_06525	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CB0101_06530	COG4251	negative regulation of phosphorylation
CB0101_06540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CB0101_06545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CB0101_06550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CB0101_06555	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CB0101_06560	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CB0101_06565	COG0217	transcriptional regulatory protein
CB0101_06570	COG0363	glucosamine-6-phosphate deaminase activity
CB0101_06575	COG2385	sporulation resulting in formation of a cellular spore
CB0101_06575	COG2247	cell wall binding repeat
CB0101_06580	COG1234	tRNA 3'-trailer cleavage
CB0101_06585	COG2010	Cytochrome c
CB0101_06600	COG2264	protein methyltransferase activity
CB0101_06605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CB0101_06625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CB0101_06665	COG0443	Heat shock 70 kDa protein
CB0101_06680	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CB0101_06695	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CB0101_06700	COG0004	ammonium transporteR
CB0101_06705	COG0459	protein refolding
CB0101_06710	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CB0101_06715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CB0101_06720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CB0101_06730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CB0101_06745	COG0515	serine threonine protein kinase
CB0101_06745	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CB0101_06775	COG0006	proline dipeptidase activity
CB0101_06780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CB0101_06785	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CB0101_06790	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CB0101_06790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CB0101_06795	COG0686	Belongs to the AlaDH PNT family
CB0101_06805	COG3012	SEC-C Motif Domain Protein
CB0101_06810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CB0101_06820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CB0101_06830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CB0101_06835	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CB0101_06845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CB0101_06855	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CB0101_06870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CB0101_06875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CB0101_06895	COG0772	Belongs to the SEDS family
CB0101_06910	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CB0101_06915	COG0347	Belongs to the P(II) protein family
CB0101_06920	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CB0101_06930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CB0101_06935	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CB0101_06940	COG4581	dead DEAH box helicase
CB0101_06960	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CB0101_06975	COG0484	heat shock protein binding
CB0101_06980	COG0357	Ribosomal RNA small subunit methyltransferase G
CB0101_07010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CB0101_07015	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CB0101_07020	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CB0101_07025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CB0101_07030	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CB0101_07035	COG0085	RNA polymerase activity
CB0101_07040	COG0084	hydrolase, TatD family'
CB0101_07045	COG0268	Binds directly to 16S ribosomal RNA
CB0101_07050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CB0101_07055	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CB0101_07060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CB0101_07065	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CB0101_07075	COG0779	Required for maturation of 30S ribosomal subunits
CB0101_07080	COG0195	Participates in both transcription termination and antitermination
CB0101_07090	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CB0101_07145	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CB0101_07150	COG3039	Transposase
CB0101_07245	COG2988	succinylglutamate desuccinylase activity
CB0101_07260	COG3039	Transposase
CB0101_07285	COG0167	dihydroorotate dehydrogenase activity
CB0101_07290	COG0328	RNA-DNA hybrid ribonuclease activity
CB0101_07300	COG0222	ribosome binding
CB0101_07305	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CB0101_07310	COG0081	regulation of translation
CB0101_07315	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CB0101_07320	COG0250	Participates in transcription elongation, termination and antitermination
CB0101_07325	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CB0101_07330	COG0542	response to heat
CB0101_07335	COG0346	lactoylglutathione lyase activity
CB0101_07340	COG0148	phosphopyruvate hydratase activity
CB0101_07345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CB0101_07365	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CB0101_07370	COG0237	dephospho-CoA kinase activity
CB0101_07390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CB0101_07405	COG0105	UTP biosynthetic process
CB0101_07425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CB0101_07425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CB0101_07430	COG3706	GGDEF domain
CB0101_07440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CB0101_07450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CB0101_07470	COG0426	domain, Protein
CB0101_07470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CB0101_07480	COG1475	DNA binding
CB0101_07490	COG3039	Transposase
CB0101_07495	COG0426	domain, Protein
CB0101_07495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CB0101_07510	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CB0101_07510	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CB0101_07515	COG0509	glycine decarboxylation via glycine cleavage system
CB0101_07520	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CB0101_07540	COG0359	binds to the 23S rRNA
CB0101_07545	COG1372	Participates in initiation and elongation during chromosome replication
CB0101_07545	COG0305	Participates in initiation and elongation during chromosome replication
CB0101_07545	COG0305	Participates in initiation and elongation during chromosome replication
CB0101_07545	COG1372	Participates in initiation and elongation during chromosome replication
CB0101_07550	COG0445	tRNA wobble uridine modification
CB0101_07585	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CB0101_07595	COG0398	Pfam SNARE associated Golgi protein
CB0101_07605	COG0525	valine-tRNA ligase activity
CB0101_07615	COG3264	Mechanosensitive ion channel
CB0101_07615	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CB0101_07635	COG2226	methyltransferase
CB0101_07645	COG3118	belongs to the thioredoxin family
CB0101_07655	COG3039	Transposase
CB0101_07735	COG3956	TIGRFAM MazG family protein
CB0101_07750	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CB0101_07755	COG0010	Belongs to the arginase family
CB0101_07770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CB0101_07775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CB0101_07780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CB0101_07785	COG0504	CTP synthase activity
CB0101_07790	COG0602	queuosine metabolic process
CB0101_07795	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CB0101_07800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CB0101_07815	COG0531	amino acid
CB0101_07825	COG0411	ABC transporter
CB0101_07835	COG0559	Belongs to the binding-protein-dependent transport system permease family
CB0101_07845	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CB0101_07855	COG0830	nickel cation binding
CB0101_07860	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CB0101_07865	COG0829	nickel cation binding
CB0101_07870	COG0831	urea catabolic process
CB0101_07875	COG0832	Belongs to the urease beta subunit family
CB0101_07880	COG0804	urea catabolic process
CB0101_07890	COG2308	Evidence 4 Homologs of previously reported genes of
CB0101_07925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CB0101_07940	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CB0101_07950	COG2116	formate transmembrane transporter activity
CB0101_07960	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CB0101_07965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CB0101_07980	COG0243	molybdopterin cofactor binding
CB0101_07985	COG2223	nitrite transmembrane transporter activity
CB0101_07995	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CB0101_08000	COG0730	response to heat
CB0101_08010	COG0521	Mo-molybdopterin cofactor biosynthetic process
CB0101_08020	COG0314	molybdopterin synthase activity
CB0101_08025	COG0303	'Molybdopterin
CB0101_08030	COG0315	cyclic pyranopterin monophosphate synthase activity
CB0101_08040	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CB0101_08045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CB0101_08050	COG0170	dolichyl monophosphate biosynthetic process
CB0101_08060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CB0101_08065	COG1049	propionate catabolic process, 2-methylcitrate cycle
CB0101_08070	COG0038	chloride channel
CB0101_08090	COG0788	formyltetrahydrofolate deformylase activity
CB0101_08100	COG2022	thiamine diphosphate biosynthetic process
CB0101_08100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CB0101_08110	COG0443	Heat shock 70 kDa protein
CB0101_08115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CB0101_08125	COG0360	Binds together with S18 to 16S ribosomal RNA
CB0101_08135	COG0137	argininosuccinate synthase activity
CB0101_08150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CB0101_08165	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CB0101_08170	COG1316	TRANSCRIPTIONal
CB0101_08175	COG0438	transferase activity, transferring glycosyl groups
CB0101_08180	COG0556	nucleotide-excision repair
CB0101_08195	COG0037	tRNA processing
CB0101_08205	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CB0101_08210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CB0101_08215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CB0101_08220	COG0544	peptidyl-prolyl cis-trans isomerase activity
CB0101_08225	COG0740	serine-type endopeptidase activity
CB0101_08230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CB0101_08240	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CB0101_08245	COG1215	transferase activity, transferring glycosyl groups
CB0101_08250	COG2385	sporulation resulting in formation of a cellular spore
CB0101_08255	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CB0101_08260	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CB0101_08275	COG2022	thiamine diphosphate biosynthetic process
CB0101_08285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CB0101_08290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CB0101_08290	COG0438	transferase activity, transferring glycosyl groups
CB0101_08295	COG0768	penicillin binding
CB0101_08310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CB0101_08310	COG0519	Catalyzes the synthesis of GMP from XMP
CB0101_08315	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CB0101_08385	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CB0101_08390	COG0511	ligase activity, forming carbon-carbon bonds
CB0101_08395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CB0101_08400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CB0101_08405	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CB0101_08410	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CB0101_08415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CB0101_08420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CB0101_08425	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CB0101_08430	COG1162	GTPase activity
CB0101_08440	COG0484	heat shock protein binding
CB0101_08445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CB0101_08450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CB0101_08475	COG2081	HI0933 family
CB0101_08480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CB0101_08485	COG0724	RNA recognition motif
CB0101_08490	COG0165	Argininosuccinate lyase
CB0101_08495	COG2208	phosphoserine phosphatase activity
CB0101_08500	COG0552	protein localization to endoplasmic reticulum
CB0101_08505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CB0101_08520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CB0101_08530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CB0101_08535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CB0101_08565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CB0101_08585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CB0101_08590	COG0497	DNA recombination
CB0101_08595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CB0101_08605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CB0101_08610	COG0592	DNA-directed DNA polymerase activity
CB0101_08625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CB0101_08630	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CB0101_08655	COG2082	Precorrin-8x methylmutase
CB0101_08670	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CB0101_08680	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CB0101_08715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CB0101_08755	COG0277	FAD linked oxidase domain protein
CB0101_08780	COG1088	dTDP-glucose 4,6-dehydratase activity
CB0101_08795	COG1216	Glycosyl transferase, family 2
CB0101_08795	COG0438	transferase activity, transferring glycosyl groups
CB0101_08880	COG2274	protein secretion by the type I secretion system
CB0101_08895	COG0297	glycogen (starch) synthase activity
CB0101_08920	COG3039	Transposase
CB0101_08930	COG0456	acetyltransferase
CB0101_08940	COG4423	Transcription factor
CB0101_08945	COG0653	protein targeting
CB0101_08955	COG2192	nodulation
CB0101_08975	COG1045	serine acetyltransferase
CB0101_08980	COG4456	Virulence-associated protein
CB0101_08990	COG1725	Transcriptional regulator
CB0101_08995	COG0412	Dienelactone hydrolase
CB0101_09010	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CB0101_09015	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CB0101_09020	COG1372	Participates in initiation and elongation during chromosome replication
CB0101_09020	COG0187	DNA topoisomerase II activity
CB0101_09030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CB0101_09035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CB0101_09040	COG0386	Belongs to the glutathione peroxidase family
CB0101_09050	COG2239	Acts as a magnesium transporter
CB0101_09055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CB0101_09065	COG1194	a g-specific adenine glycosylase
CB0101_09075	COG0802	atpase or kinase
CB0101_09080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CB0101_09085	COG0586	Pfam SNARE associated Golgi protein
CB0101_09090	COG0629	single-stranded DNA binding
CB0101_09100	COG1792	Involved in formation and maintenance of cell shape
CB0101_09115	COG0745	RESPONSE REGULATOR receiver
CB0101_09120	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CB0101_09145	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CB0101_09165	COG0515	serine threonine protein kinase
CB0101_09185	COG1473	amidohydrolase
CB0101_09200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CB0101_09210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CB0101_09215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CB0101_09220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CB0101_09225	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CB0101_09240	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CB0101_09250	COG0571	ribonuclease III activity
CB0101_09280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CB0101_09285	COG0058	SHG alpha-glucan phosphorylase activity
CB0101_09290	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CB0101_09295	COG0475	glutathione-regulated potassium exporter activity
CB0101_09320	COG0277	FAD linked oxidase domain protein
CB0101_09350	COG0531	amino acid
CB0101_09355	COG0247	lactate metabolic process
CB0101_09360	COG0538	isocitrate dehydrogenase activity
CB0101_09370	COG5398	heme oxygenase
CB0101_09380	COG1132	(ABC) transporter
CB0101_09385	COG1132	(ABC) transporter
CB0101_09390	COG0438	transferase activity, transferring glycosyl groups
CB0101_09420	COG0617	tRNA 3'-terminal CCA addition
CB0101_09435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CB0101_09440	COG0124	histidyl-tRNA synthetase
CB0101_09445	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CB0101_09480	COG4447	cellulose binding
CB0101_09490	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CB0101_09505	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CB0101_09510	COG3842	ATPase activity
CB0101_09520	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CB0101_09520	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CB0101_09530	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CB0101_09545	COG0494	nUDIX hydrolase
CB0101_09550	COG0415	Belongs to the DNA photolyase family
CB0101_09575	COG0415	Belongs to the DNA photolyase family
CB0101_09580	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CB0101_09585	COG0131	Imidazoleglycerol-phosphate dehydratase
CB0101_09590	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CB0101_09605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CB0101_09610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CB0101_09620	COG0354	folic acid binding
CB0101_09625	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CB0101_09645	COG1253	flavin adenine dinucleotide binding
CB0101_09650	COG0673	inositol 2-dehydrogenase activity
CB0101_09670	COG0343	queuine tRNA-ribosyltransferase activity
CB0101_09675	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CB0101_09680	COG2205	protein histidine kinase activity
CB0101_09695	COG0138	bifunctional purine biosynthesis protein purh
CB0101_09710	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CB0101_09715	COG1489	DNA binding
CB0101_09720	COG0728	peptidoglycan biosynthetic process
CB0101_09745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CB0101_09750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CB0101_09755	COG1546	Belongs to the CinA family
CB0101_09755	COG1058	Belongs to the CinA family
CB0101_09760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CB0101_09765	COG0066	3-isopropylmalate dehydratase activity
CB0101_09800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CB0101_09805	COG0193	aminoacyl-tRNA hydrolase activity
CB0101_09820	COG4372	Transposase
CB0101_09825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CB0101_09830	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CB0101_09840	COG0717	Belongs to the dCTP deaminase family
CB0101_09850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CB0101_09865	COG0741	lytic transglycosylase activity
CB0101_09875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CB0101_09890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CB0101_09915	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CB0101_09935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CB0101_09940	COG1402	creatininase
CB0101_09950	COG2094	Belongs to the DNA glycosylase MPG family
CB0101_09960	COG2801	Transposase and inactivated derivatives
CB0101_10020	COG2094	Belongs to the DNA glycosylase MPG family
CB0101_10025	COG0540	Belongs to the ATCase OTCase family
CB0101_10050	COG3536	Protein conserved in bacteria
CB0101_10055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CB0101_10070	COG2046	Belongs to the sulfate adenylyltransferase family
CB0101_10070	COG0529	Catalyzes the synthesis of activated sulfate
CB0101_10075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CB0101_10090	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CB0101_10095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CB0101_10105	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CB0101_10110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CB0101_10115	COG2205	protein histidine kinase activity
CB0101_10130	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CB0101_10135	COG0436	Aminotransferase
CB0101_10145	COG1530	ribonuclease E activity
CB0101_10150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CB0101_10160	COG1605	Chorismate mutase
CB0101_10160	COG0077	Prephenate dehydratase
CB0101_10165	COG2226	methyltransferase
CB0101_10175	COG0051	transcription antitermination factor activity, RNA binding
CB0101_10180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CB0101_10185	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CB0101_10190	COG0049	tRNA binding
CB0101_10195	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CB0101_10210	COG0069	glutamate synthase activity
CB0101_10210	COG0070	glutamate synthase
CB0101_10210	COG0067	glutamate synthase
CB0101_10220	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CB0101_10240	COG2885	chlorophyll binding
CB0101_10245	COG2885	chlorophyll binding
CB0101_10250	COG0009	L-threonylcarbamoyladenylate synthase
CB0101_10255	COG2890	protein-(glutamine-N5) methyltransferase activity
CB0101_10260	COG0758	DNA mediated transformation
CB0101_10270	COG0589	response to stress
CB0101_10295	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CB0101_10300	COG0539	negative regulation of cytoplasmic translation
CB0101_10305	COG0546	phosphoglycolate phosphatase activity
CB0101_10310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CB0101_10315	COG1070	Carbohydrate kinase
CB0101_10345	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CB0101_10395	COG1413	lyase activity
CB0101_10400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CB0101_10405	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CB0101_10405	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CB0101_10410	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CB0101_10415	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CB0101_10465	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CB0101_10465	COG2755	lipolytic protein G-D-S-L family
CB0101_10485	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CB0101_10505	COG0408	coproporphyrinogen oxidase activity
CB0101_10510	COG0489	protein tyrosine kinase activity
CB0101_10515	COG0772	Belongs to the SEDS family
CB0101_10530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CB0101_10535	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CB0101_10540	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CB0101_10555	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CB0101_10560	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CB0101_10575	COG1606	tRNA processing
CB0101_10580	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CB0101_10645	COG3854	ATPases associated with a variety of cellular activities
CB0101_10660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CB0101_10665	COG0088	Forms part of the polypeptide exit tunnel
CB0101_10670	COG0089	rRNA binding
CB0101_10675	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CB0101_10680	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CB0101_10685	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CB0101_10690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CB0101_10695	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CB0101_10700	COG0255	Belongs to the universal ribosomal protein uL29 family
CB0101_10705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CB0101_10710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CB0101_10715	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CB0101_10720	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CB0101_10725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CB0101_10730	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CB0101_10735	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CB0101_10740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CB0101_10745	COG0200	Binds to the 23S rRNA
CB0101_10750	COG0201	protein transport
CB0101_10755	COG0563	adenylate kinase activity
CB0101_10760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CB0101_10765	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CB0101_10770	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CB0101_10775	COG0202	RNA polymerase activity
CB0101_10780	COG0203	ribosomal protein L17
CB0101_10785	COG0101	tRNA pseudouridine synthase activity
CB0101_10790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CB0101_10795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CB0101_10800	COG0254	rRNA binding
CB0101_10805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CB0101_10815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CB0101_10840	COG0745	RESPONSE REGULATOR receiver
CB0101_10860	COG5505	Protein of unknown function (DUF819)
CB0101_10865	COG0463	Glycosyl transferase, family 2
CB0101_10900	COG0463	Glycosyl transferase, family 2
CB0101_10920	COG3659	wide pore channel activity
CB0101_10925	COG3659	wide pore channel activity
CB0101_10930	COG0484	heat shock protein binding
CB0101_10945	COG1090	epimerase
CB0101_10975	COG0316	Belongs to the HesB IscA family
CB0101_10980	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CB0101_10995	COG1587	Uroporphyrinogen-III synthase
CB0101_11000	COG0457	Tetratricopeptide repeat
CB0101_11000	COG0463	Glycosyl transferase, family 2
CB0101_11010	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CB0101_11020	COG0625	glutathione transferase activity
CB0101_11035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CB0101_11065	COG1032	radical SAM domain protein
CB0101_11080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CB0101_11085	COG4243	Vitamin k epoxide reductase
CB0101_11090	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CB0101_11095	COG1555	photosystem II stabilization
CB0101_11105	COG1968	undecaprenyl-diphosphatase activity
CB0101_11160	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CB0101_11170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CB0101_11185	COG0514	ATP-dependent DNA helicase (RecQ)
CB0101_11190	COG3942	CHAP domain
CB0101_11190	COG1388	LysM domain
CB0101_11195	COG1012	belongs to the aldehyde dehydrogenase family
CB0101_11205	COG4191	Histidine kinase
CB0101_11225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CB0101_11295	COG0745	RESPONSE REGULATOR receiver
CB0101_11300	COG5002	protein histidine kinase activity
CB0101_11365	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CB0101_11390	COG1970	mechanosensitive ion channel activity
CB0101_11405	COG2197	response regulator
CB0101_11530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CB0101_11545	COG1160	GTP binding
CB0101_11550	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CB0101_11560	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CB0101_11565	COG1799	cell septum assembly
CB0101_11570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CB0101_11575	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CB0101_11590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CB0101_11595	COG2211	Major facilitator Superfamily
CB0101_11615	COG0776	regulation of translation
CB0101_11635	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CB0101_11650	COG0113	porphobilinogen synthase activity
CB0101_11675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CB0101_11685	COG1193	negative regulation of DNA recombination
CB0101_11690	COG3842	ATPase activity
CB0101_11695	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CB0101_11710	COG0488	(ABC) transporter
CB0101_11715	COG2801	Transposase and inactivated derivatives
CB0101_11735	COG3039	Transposase
CB0101_11750	COG2988	succinylglutamate desuccinylase activity
CB0101_11910	COG3039	Transposase
CB0101_11980	COG0582	viral genome integration into host DNA
CB0101_12020	COG1970	mechanosensitive ion channel activity
CB0101_12110	COG0745	RESPONSE REGULATOR receiver
CB0101_12125	COG1799	cell septum assembly
CB0101_12185	COG2197	response regulator
CB0101_12195	COG3659	wide pore channel activity
CB0101_12230	COG3039	Transposase
CB0101_12295	COG0582	viral genome integration into host DNA
CB0101_12330	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CB0101_12355	COG2337	Toxic component of a toxin-antitoxin (TA) module
CB0101_12400	COG3275	phosphorelay sensor kinase activity
CB0101_12450	COG4178	(ABC) transporter
CB0101_12460	COG0745	RESPONSE REGULATOR receiver
CB0101_12470	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CB0101_12475	COG0271	Belongs to the BolA IbaG family
CB0101_12490	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CB0101_12510	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CB0101_12515	COG1074	ATP-dependent DNA helicase activity
CB0101_12520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CB0101_12525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CB0101_12535	COG0513	Belongs to the DEAD box helicase family
CB0101_12545	COG0724	RNA recognition motif
CB0101_12560	COG1132	(ABC) transporter
CB0101_12575	COG1285	pathogenesis
CB0101_12630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CB0101_12635	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CB0101_12655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CB0101_12660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CB0101_12665	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CB0101_12670	COG0019	diaminopimelate decarboxylase activity
CB0101_12680	COG0542	response to heat
CB0101_12740	COG2119	membrane
CB0101_12745	COG0371	Dehydrogenase
CB0101_12750	COG0596	Alpha beta hydrolase
CB0101_12760	COG0575	Belongs to the CDS family
CB0101_12765	COG2242	protein methyltransferase activity
CB0101_12765	COG2241	protein methyltransferase activity
CB0101_12775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CB0101_12785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CB0101_12790	COG1187	pseudouridine synthase activity
CB0101_12800	COG1640	4-alpha-glucanotransferase
CB0101_12805	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
CB0101_12820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CB0101_12845	COG2205	protein histidine kinase activity
CB0101_12860	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CB0101_12865	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CB0101_12870	COG3409	Peptidoglycan-binding domain 1 protein
CB0101_12870	COG3429	Glucose-6-phosphate dehydrogenase subunit
CB0101_12875	COG1797	cobyrinic acid a,c-diamide synthase activity
CB0101_12880	COG0406	alpha-ribazole phosphatase activity
CB0101_12885	COG1254	Belongs to the acylphosphatase family
CB0101_12895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CB0101_12915	COG1480	7TM receptor with intracellular HD hydrolase
CB0101_12925	COG4095	Psort location CytoplasmicMembrane, score
CB0101_12930	COG0564	pseudouridine synthase activity
CB0101_12945	COG1799	cell septum assembly
CB0101_12985	COG0395	ABC-type sugar transport system, permease component
CB0101_12990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CB0101_13000	COG1543	Belongs to the glycosyl hydrolase 57 family
CB0101_13010	COG0644	oxidoreductase
CB0101_13015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CB0101_13030	COG0516	GMP reductase activity
CB0101_13035	COG3118	belongs to the thioredoxin family
CB0101_13040	COG1611	Belongs to the LOG family
CB0101_13045	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CB0101_13050	COG0116	Belongs to the methyltransferase superfamily
CB0101_13050	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CB0101_13060	COG2010	Cytochrome c
CB0101_13065	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CB0101_13080	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CB0101_13085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CB0101_13105	COG2166	iron-sulfur cluster assembly
CB0101_13110	COG0460	homoserine dehydrogenase
CB0101_13120	COG0747	negative chemotaxis
CB0101_13130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CB0101_13140	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CB0101_13145	COG0012	GTP binding
CB0101_13165	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CB0101_13170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CB0101_13185	COG0194	GDP metabolic process
CB0101_13195	COG0805	protein transport
CB0101_13205	COG0723	plastoquinol--plastocyanin reductase activity
CB0101_13210	COG0739	heme binding
CB0101_13240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CB0101_13245	COG1619	proteins homologs of microcin C7 resistance protein MccF
CB0101_13250	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CB0101_13260	COG0569	domain protein
CB0101_13265	COG1028	Short-chain dehydrogenase reductase Sdr
CB0101_13275	COG0459	protein refolding
CB0101_13285	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CB0101_13305	COG0109	protoheme IX farnesyltransferase activity
CB0101_13320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CB0101_13325	COG1845	cytochrome c oxidase, subunit III
CB0101_13360	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CB0101_13375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CB0101_13385	COG0577	efflux transmembrane transporter activity
CB0101_13385	COG1136	(ABC) transporter
CB0101_13390	COG0739	heme binding
CB0101_13395	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CB0101_13395	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CB0101_13400	COG0436	Aminotransferase
CB0101_13405	COG3118	belongs to the thioredoxin family
CB0101_13410	COG1842	Phage shock protein A
CB0101_13415	COG0668	transmembrane transport
CB0101_13430	COG0438	transferase activity, transferring glycosyl groups
CB0101_13435	COG0697	spore germination
CB0101_13440	COG0616	signal peptide processing
CB0101_13455	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CB0101_13460	COG0594	ribonuclease P activity
CB0101_13470	COG0706	membrane insertase activity
CB0101_13545	COG3039	Transposase
CB0101_13550	COG4974	Belongs to the 'phage' integrase family
CB0101_13555	COG1104	cysteine desulfurase activity
CB0101_13560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CB0101_13570	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CB0101_13585	COG0134	indole-3-glycerol-phosphate synthase activity
CB0101_13590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CB0101_13595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CB0101_13610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CB0101_13615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CB0101_13620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CB0101_13660	COG4948	Mandelate Racemase Muconate Lactonizing
CB0101_13665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CB0101_13670	COG1181	Belongs to the D-alanine--D-alanine ligase family
CB0101_13685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CB0101_13695	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CB0101_13700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CB0101_13705	COG4956	integral membrane protein (PIN domain superfamily)
CB0101_13710	COG0740	serine-type endopeptidase activity
CB0101_13715	COG0740	serine-type endopeptidase activity
CB0101_13720	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CB0101_13725	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CB0101_13730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CB0101_13735	COG0438	transferase activity, transferring glycosyl groups
CB0101_13765	COG0752	glycyl-tRNA synthetase alpha subunit
CB0101_13780	COG0107	imidazoleglycerol-phosphate synthase activity
CB0101_13790	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CB0101_13800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CB0101_13800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CB0101_13805	COG3695	enzyme binding
CB0101_13810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CB0101_13830	COG0745	RESPONSE REGULATOR receiver
CB0101_13845	COG5002	protein histidine kinase activity
CB0101_13855	COG3039	Transposase
CB0101_13865	COG2801	Transposase and inactivated derivatives
CB0101_13880	COG4968	Prepilin-type N-terminal cleavage methylation domain
CB0101_13925	COG0481	GTPase activity
CB0101_13935	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CB0101_13940	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CB0101_13945	COG0579	oxidoreductase
CB0101_13950	COG0750	zinc metalloprotease
CB0101_13955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CB0101_13960	COG1185	polyribonucleotide nucleotidyltransferase activity
CB0101_13965	COG1218	3'(2'),5'-bisphosphate nucleotidase
CB0101_13970	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CB0101_14030	COG0484	heat shock protein binding
CB0101_14035	COG4243	Vitamin k epoxide reductase
CB0101_14045	COG0393	Putative heavy-metal-binding
CB0101_14060	COG0116	Belongs to the methyltransferase superfamily
CB0101_14065	COG3263	regulation of cellular component size
CB0101_14090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CB0101_14105	COG0439	Biotin carboxylase
CB0101_14120	COG0515	serine threonine protein kinase
CB0101_14140	COG4178	(ABC) transporter
CB0101_14145	COG0537	adenosine 5'-monophosphoramidase activity
CB0101_14150	COG0606	chelatase, subunit chli
CB0101_14155	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CB0101_14170	COG0242	peptide deformylase activity
CB0101_14190	COG0235	Class ii aldolase
CB0101_14195	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CB0101_14210	COG1231	oxidoreductase activity
CB0101_14225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CB0101_14230	COG0719	Fe-S assembly protein
CB0101_14235	COG0396	ATPase activity
CB0101_14240	COG0719	Fe-S assembly protein
CB0101_14245	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
CB0101_14270	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CB0101_14285	COG0457	Tetratricopeptide repeat
CB0101_14295	COG0033	Phosphoglucomutase
CB0101_14320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CB0101_14330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CB0101_14355	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CB0101_14360	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CB0101_14365	COG0175	sulfate reduction
CB0101_14370	COG1252	NADH dehydrogenase
CB0101_14380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CB0101_14390	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CB0101_14400	COG0488	(ABC) transporter
CB0101_14410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CB0101_14425	COG1643	Atp-dependent helicase
CB0101_14445	COG1570	exodeoxyribonuclease VII activity
CB0101_14500	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CB0101_14505	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CB0101_14510	COG0793	Belongs to the peptidase S41A family
CB0101_14515	COG1078	dGTPase activity
CB0101_14520	COG0850	regulation of cytokinetic process
CB0101_14540	COG2894	cell division
CB0101_14545	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CB0101_14580	COG1122	ATPase activity
CB0101_14595	COG0470	DNA polymerase III
CB0101_14600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CB0101_14605	COG2217	Heavy metal translocating P-type atpase
CB0101_14610	COG0457	Tetratricopeptide repeat
CB0101_14615	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CB0101_14620	COG0745	RESPONSE REGULATOR receiver
CB0101_14625	COG0416	fatty acid biosynthetic process
CB0101_14630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CB0101_14635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CB0101_14650	COG1214	PFAM Peptidase M22, glycoprotease
CB0101_14665	COG0724	RNA recognition motif
CB0101_14675	COG1562	ergosterol biosynthetic process
CB0101_14680	COG0493	'glutamate synthase
CB0101_14680	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CB0101_14695	COG0583	DNA-binding transcription factor activity
CB0101_14705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CB0101_14715	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CB0101_14730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CB0101_14750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CB0101_14755	COG0713	ATP synthesis coupled electron transport
CB0101_14760	COG0839	Belongs to the complex I subunit 6 family
CB0101_14765	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CB0101_14770	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CB0101_14775	COG0372	Belongs to the citrate synthase family
CB0101_14780	COG2062	phosphohistidine phosphatase, SixA
CB0101_14790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CB0101_14795	COG1420	regulation of RNA biosynthetic process
CB0101_14800	COG0133	tryptophan synthase activity
CB0101_14810	COG0023	Translation Initiation Factor
CB0101_14815	COG0750	zinc metalloprotease
CB0101_14820	COG0529	Catalyzes the synthesis of activated sulfate
CB0101_14825	COG0628	permease
CB0101_14835	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CB0101_14840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CB0101_14845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CB0101_14855	COG0564	pseudouridine synthase activity
CB0101_14860	COG0745	RESPONSE REGULATOR receiver
CB0101_14870	COG1104	cysteine desulfurase activity
CB0101_14885	COG0275	rRNA processing
CB0101_14890	COG0649	NAD binding
CB0101_14900	COG0824	Thioesterase
CB0101_14910	COG0318	PFAM AMP-dependent synthetase and ligase
CB0101_14920	COG1575	Belongs to the MenA family. Type 1 subfamily
CB0101_14930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CB0101_14935	COG0189	ligase activity
CB0101_14940	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CB0101_14965	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CB0101_14970	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CB0101_14985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CB0101_14990	COG0018	arginyl-trna synthetase
CB0101_14995	COG0515	serine threonine protein kinase
CB0101_15010	COG0157	Belongs to the NadC ModD family
CB0101_15015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CB0101_15025	COG4106	trans-aconitate 2-methyltransferase activity
CB0101_15040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CB0101_15045	COG4172	Belongs to the ABC transporter superfamily
CB0101_15050	COG0564	pseudouridine synthase activity
CB0101_15060	COG0589	response to stress
CB0101_15065	COG0126	phosphoglycerate kinase activity
CB0101_15080	COG0745	RESPONSE REGULATOR receiver
CB0101_15090	COG2084	Dehydrogenase
CB0101_15100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CB0101_15115	COG1450	Type ii and iii secretion system protein