locus-tag	class	description
H8F24_00025	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_00030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8F24_00040	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8F24_00045	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
H8F24_00065	COG4451	ribulose bisphosphate carboxylase, small
H8F24_00070	COG1850	ribulose-bisphosphate carboxylase activity
H8F24_00075	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8F24_00090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8F24_00095	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8F24_00100	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H8F24_00105	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H8F24_00110	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
H8F24_00135	COG0730	response to heat
H8F24_00140	COG0095	Lipoate-protein ligase
H8F24_00145	COG0517	IMP dehydrogenase activity
H8F24_00145	COG1994	Peptidase M50
H8F24_00150	COG0135	phosphoribosylanthranilate isomerase activity
H8F24_00160	COG0302	gtp cyclohydrolase
H8F24_00170	COG0825	malonyl-CoA metabolic process
H8F24_00175	COG5322	oxidoreductase activity
H8F24_00180	COG3396	Phenylacetate-CoA oxygenase
H8F24_00190	COG0539	negative regulation of cytoplasmic translation
H8F24_00205	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H8F24_00225	COG0737	Belongs to the 5'-nucleotidase family
H8F24_00230	COG0574	Belongs to the PEP-utilizing enzyme family
H8F24_00230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8F24_00250	COG0028	Belongs to the TPP enzyme family
H8F24_00260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F24_00280	COG0528	UMP kinase activity
H8F24_00285	COG0233	cytoplasmic translational termination
H8F24_00290	COG0644	oxidoreductase
H8F24_00300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8F24_00320	COG0588	phosphoglycerate mutase activity
H8F24_00330	COG0681	Belongs to the peptidase S26 family
H8F24_00350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F24_00355	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H8F24_00365	COG0442	prolyl-tRNA aminoacylation
H8F24_00375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H8F24_00380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8F24_00410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H8F24_00420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8F24_00425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F24_00430	COG1215	transferase activity, transferring glycosyl groups
H8F24_00450	COG0181	hydroxymethylbilane synthase activity
H8F24_00470	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H8F24_00475	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F24_00480	COG3659	wide pore channel activity
H8F24_00490	COG0786	glutamate:sodium symporter activity
H8F24_00500	COG2066	Belongs to the glutaminase family
H8F24_00540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8F24_00580	COG0426	domain, Protein
H8F24_00580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F24_00585	COG0284	orotidine-5'-phosphate decarboxylase activity
H8F24_00590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8F24_00600	COG2197	response regulator
H8F24_00615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8F24_00635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F24_00645	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F24_00650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8F24_00655	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H8F24_00665	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H8F24_00675	COG0151	Belongs to the GarS family
H8F24_00680	COG5002	protein histidine kinase activity
H8F24_00685	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H8F24_00705	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H8F24_00710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F24_00715	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8F24_00720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H8F24_00725	COG0217	transcriptional regulatory protein
H8F24_00730	COG0363	glucosamine-6-phosphate deaminase activity
H8F24_00735	COG2385	sporulation resulting in formation of a cellular spore
H8F24_00740	COG1234	tRNA 3'-trailer cleavage
H8F24_00745	COG2010	Cytochrome c
H8F24_00760	COG2264	protein methyltransferase activity
H8F24_00765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8F24_00785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8F24_00810	COG0443	Heat shock 70 kDa protein
H8F24_00825	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H8F24_00850	COG0459	protein refolding
H8F24_00855	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H8F24_00860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H8F24_00865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H8F24_00875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8F24_00925	COG0006	proline dipeptidase activity
H8F24_00930	COG1253	flavin adenine dinucleotide binding
H8F24_00935	COG1160	GTP binding
H8F24_00940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H8F24_00945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H8F24_00945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F24_00950	COG0686	Belongs to the AlaDH PNT family
H8F24_00955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F24_00965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8F24_00975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H8F24_00980	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H8F24_00990	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8F24_00995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8F24_01015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F24_01020	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F24_01040	COG0772	Belongs to the SEDS family
H8F24_01055	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8F24_01060	COG0347	Belongs to the P(II) protein family
H8F24_01075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H8F24_01085	COG1088	dTDP-glucose 4,6-dehydratase activity
H8F24_01095	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H8F24_01110	COG4581	dead DEAH box helicase
H8F24_01115	COG0385	Bile acid
H8F24_01120	COG0156	8-amino-7-oxononanoate synthase activity
H8F24_01135	COG4106	trans-aconitate 2-methyltransferase activity
H8F24_01135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H8F24_01140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8F24_01155	COG0357	Ribosomal RNA small subunit methyltransferase G
H8F24_01185	COG2223	nitrite transmembrane transporter activity
H8F24_01190	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H8F24_01200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8F24_01205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8F24_01210	COG0085	RNA polymerase activity
H8F24_01215	COG0084	hydrolase, TatD family'
H8F24_01220	COG0268	Binds directly to 16S ribosomal RNA
H8F24_01225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8F24_01230	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H8F24_01240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8F24_01245	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H8F24_01255	COG0779	Required for maturation of 30S ribosomal subunits
H8F24_01260	COG0195	Participates in both transcription termination and antitermination
H8F24_01270	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H8F24_01300	COG0484	heat shock protein binding
H8F24_01315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8F24_01325	COG0438	transferase activity, transferring glycosyl groups
H8F24_01365	COG2274	protein secretion by the type I secretion system
H8F24_01380	COG0438	transferase activity, transferring glycosyl groups
H8F24_01380	COG1216	Glycosyl transferase, family 2
H8F24_01410	COG2988	succinylglutamate desuccinylase activity
H8F24_01415	COG0435	Glutathione S-transferase
H8F24_01425	COG0488	(ABC) transporter
H8F24_01440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H8F24_01445	COG3842	ATPase activity
H8F24_01450	COG1193	negative regulation of DNA recombination
H8F24_01460	COG0113	porphobilinogen synthase activity
H8F24_01465	COG0484	heat shock protein binding
H8F24_01525	COG4974	Belongs to the 'phage' integrase family
H8F24_01640	COG0798	PFAM Bile acid sodium symporter
H8F24_01750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F24_01770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F24_01810	COG0288	reversible hydration of carbon dioxide
H8F24_01870	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H8F24_01905	COG2801	Transposase and inactivated derivatives
H8F24_01945	COG3328	transposase activity
H8F24_02080	COG0784	Response regulator, receiver
H8F24_02080	COG2198	Histidine kinase
H8F24_02080	COG5002	protein histidine kinase activity
H8F24_02090	COG0784	Response regulator, receiver
H8F24_02090	COG2198	Histidine kinase
H8F24_02090	COG2205	protein histidine kinase activity
H8F24_02105	COG1012	belongs to the aldehyde dehydrogenase family
H8F24_02110	COG1705	Flagellar rod assembly protein muramidase FlgJ
H8F24_02110	COG1388	LysM domain
H8F24_02115	COG0514	ATP-dependent DNA helicase (RecQ)
H8F24_02120	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H8F24_02125	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H8F24_02135	COG3842	ATPase activity
H8F24_02150	COG1653	transport
H8F24_02155	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H8F24_02170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H8F24_02175	COG0235	Class ii aldolase
H8F24_02180	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H8F24_02220	COG1538	Outer membrane efflux protein
H8F24_02230	COG1968	undecaprenyl-diphosphatase activity
H8F24_02240	COG1555	photosystem II stabilization
H8F24_02245	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H8F24_02250	COG4243	Vitamin k epoxide reductase
H8F24_02255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8F24_02270	COG1032	radical SAM domain protein
H8F24_02305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H8F24_02330	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H8F24_02335	COG1472	Belongs to the glycosyl hydrolase 3 family
H8F24_02340	COG1587	Uroporphyrinogen-III synthase
H8F24_02355	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H8F24_02360	COG0316	Belongs to the HesB IscA family
H8F24_02380	COG1090	epimerase
H8F24_02395	COG0484	heat shock protein binding
H8F24_02400	COG3659	wide pore channel activity
H8F24_02405	COG3659	wide pore channel activity
H8F24_02450	COG1122	ATPase activity
H8F24_02460	COG0745	RESPONSE REGULATOR receiver
H8F24_02470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8F24_02475	COG2217	Heavy metal translocating P-type atpase
H8F24_02480	COG3063	Type IV pilus biogenesis stability protein PilW
H8F24_02485	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H8F24_02490	COG0745	RESPONSE REGULATOR receiver
H8F24_02495	COG0416	fatty acid biosynthetic process
H8F24_02500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8F24_02505	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8F24_02520	COG1214	PFAM Peptidase M22, glycoprotease
H8F24_02530	COG0617	tRNA 3'-terminal CCA addition
H8F24_02545	COG1562	ergosterol biosynthetic process
H8F24_02550	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H8F24_02550	COG0493	'glutamate synthase
H8F24_02565	COG0583	DNA-binding transcription factor activity
H8F24_02575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8F24_02580	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_02595	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H8F24_02605	COG2197	response regulator
H8F24_02615	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8F24_02620	COG0713	ATP synthesis coupled electron transport
H8F24_02625	COG0839	Belongs to the complex I subunit 6 family
H8F24_02635	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H8F24_02640	COG0372	Belongs to the citrate synthase family
H8F24_02645	COG2062	phosphohistidine phosphatase, SixA
H8F24_02655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8F24_02660	COG1420	regulation of RNA biosynthetic process
H8F24_02670	COG0133	tryptophan synthase activity
H8F24_02680	COG0023	Translation Initiation Factor
H8F24_02690	COG2376	Dihydroxyacetone kinase
H8F24_02700	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
H8F24_02705	COG2116	formate transmembrane transporter activity
H8F24_02710	COG0018	arginyl-trna synthetase
H8F24_02725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8F24_02740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H8F24_02745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H8F24_02780	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H8F24_02785	COG0189	ligase activity
H8F24_02790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F24_02800	COG1575	Belongs to the MenA family. Type 1 subfamily
H8F24_02810	COG0318	PFAM AMP-dependent synthetase and ligase
H8F24_02825	COG0824	Thioesterase
H8F24_02840	COG0649	NAD binding
H8F24_02845	COG0275	rRNA processing
H8F24_02855	COG1104	cysteine desulfurase activity
H8F24_02870	COG0564	pseudouridine synthase activity
H8F24_02885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F24_02895	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H8F24_02900	COG0628	permease
H8F24_02905	COG0529	Catalyzes the synthesis of activated sulfate
H8F24_02915	COG1799	cell septum assembly
H8F24_02930	COG1119	ATPase activity
H8F24_02970	COG1028	Short-chain dehydrogenase reductase Sdr
H8F24_03030	COG2144	transferase activity, transferring acyl groups
H8F24_03050	COG2226	methyltransferase
H8F24_03090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F24_03115	COG0105	UTP biosynthetic process
H8F24_03120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8F24_03120	COG2022	thiamine diphosphate biosynthetic process
H8F24_03125	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H8F24_03145	COG0237	dephospho-CoA kinase activity
H8F24_03155	COG4260	virion core protein, lumpy skin disease virus
H8F24_03160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H8F24_03175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8F24_03175	COG2755	lipolytic protein G-D-S-L family
H8F24_03185	COG2801	Transposase and inactivated derivatives
H8F24_03205	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8F24_03210	COG0148	phosphopyruvate hydratase activity
H8F24_03215	COG0346	lactoylglutathione lyase activity
H8F24_03220	COG0542	response to heat
H8F24_03225	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H8F24_03235	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H8F24_03240	COG0081	regulation of translation
H8F24_03245	COG0765	amino acid transport
H8F24_03255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H8F24_03260	COG0222	ribosome binding
H8F24_03270	COG0328	RNA-DNA hybrid ribonuclease activity
H8F24_03275	COG0167	dihydroorotate dehydrogenase activity
H8F24_03305	COG2801	Transposase and inactivated derivatives
H8F24_03345	COG0714	Associated with various cellular activities
H8F24_03350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8F24_03355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8F24_03365	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H8F24_03370	COG2084	Dehydrogenase
H8F24_03415	COG0126	phosphoglycerate kinase activity
H8F24_03420	COG0589	response to stress
H8F24_03430	COG0564	pseudouridine synthase activity
H8F24_03445	COG4172	Belongs to the ABC transporter superfamily
H8F24_03450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8F24_03470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H8F24_03475	COG0157	Belongs to the NadC ModD family
H8F24_03490	COG0641	radical SAM
H8F24_03505	COG1231	oxidoreductase activity
H8F24_03515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F24_03525	COG0475	glutathione-regulated potassium exporter activity
H8F24_03540	COG0628	permease
H8F24_03550	COG0415	Belongs to the DNA photolyase family
H8F24_03575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H8F24_03585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8F24_03655	COG5002	protein histidine kinase activity
H8F24_03655	COG0784	Response regulator, receiver
H8F24_03655	COG2205	protein histidine kinase activity
H8F24_03670	COG3437	response regulator, receiver
H8F24_03690	COG2205	protein histidine kinase activity
H8F24_03690	COG5002	protein histidine kinase activity
H8F24_03690	COG0784	Response regulator, receiver
H8F24_03765	COG2801	Transposase and inactivated derivatives
H8F24_03830	COG5001	Diguanylate cyclase
H8F24_03830	COG3447	MASE1 domain protein
H8F24_03830	COG5002	protein histidine kinase activity
H8F24_03880	COG3956	TIGRFAM MazG family protein
H8F24_03890	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H8F24_03895	COG0010	Belongs to the arginase family
H8F24_03910	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H8F24_03915	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8F24_03920	COG1215	transferase activity, transferring glycosyl groups
H8F24_03925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8F24_03925	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8F24_03930	COG1028	Short-chain dehydrogenase reductase Sdr
H8F24_03935	COG1051	belongs to the nudix hydrolase family
H8F24_03945	COG3328	transposase activity
H8F24_03950	COG3328	transposase activity
H8F24_03975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8F24_04000	COG2770	Histidine kinase
H8F24_04000	COG2208	phosphoserine phosphatase activity
H8F24_04030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8F24_04040	COG0783	Belongs to the Dps family
H8F24_04050	COG0602	queuosine metabolic process
H8F24_04055	COG4574	serine-type endopeptidase inhibitor activity
H8F24_04060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H8F24_04080	COG0411	ABC transporter
H8F24_04100	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H8F24_04105	COG0830	nickel cation binding
H8F24_04110	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H8F24_04120	COG0831	urea catabolic process
H8F24_04125	COG0832	Belongs to the urease beta subunit family
H8F24_04130	COG0804	urea catabolic process
H8F24_04150	COG2308	Evidence 4 Homologs of previously reported genes of
H8F24_04165	COG0058	SHG alpha-glucan phosphorylase activity
H8F24_04185	COG5001	Diguanylate cyclase
H8F24_04185	COG3300	MHYT domain
H8F24_04190	COG5001	Diguanylate cyclase
H8F24_04210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8F24_04215	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H8F24_04215	COG3264	Mechanosensitive ion channel
H8F24_04225	COG2226	methyltransferase
H8F24_04245	COG0525	valine-tRNA ligase activity
H8F24_04290	COG1970	mechanosensitive ion channel activity
H8F24_04370	COG1970	mechanosensitive ion channel activity
H8F24_04380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H8F24_04385	COG0398	Pfam SNARE associated Golgi protein
H8F24_04400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8F24_04440	COG0445	tRNA wobble uridine modification
H8F24_04445	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H8F24_04480	COG2124	cytochrome p450
H8F24_04495	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8F24_04500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8F24_04505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8F24_04510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_04515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8F24_04545	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H8F24_04555	COG0571	ribonuclease III activity
H8F24_04590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8F24_04595	COG0390	transport system, permease component
H8F24_04615	COG0058	SHG alpha-glucan phosphorylase activity
H8F24_04620	COG0475	glutathione-regulated potassium exporter activity
H8F24_04645	COG0277	FAD linked oxidase domain protein
H8F24_04655	COG0435	Glutathione S-transferase
H8F24_04660	COG0247	lactate metabolic process
H8F24_04665	COG0538	isocitrate dehydrogenase activity
H8F24_04675	COG5398	heme oxygenase
H8F24_04690	COG0438	transferase activity, transferring glycosyl groups
H8F24_04710	COG0438	transferase activity, transferring glycosyl groups
H8F24_04715	COG0438	transferase activity, transferring glycosyl groups
H8F24_04735	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H8F24_04750	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H8F24_04760	COG0617	tRNA 3'-terminal CCA addition
H8F24_04765	COG0709	Synthesizes selenophosphate from selenide and ATP
H8F24_04770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8F24_04775	COG0124	histidyl-tRNA synthetase
H8F24_04780	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H8F24_04785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8F24_04815	COG4447	cellulose binding
H8F24_04820	COG1773	rubredoxin
H8F24_04825	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_04830	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_04835	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_04840	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H8F24_04845	COG3842	ATPase activity
H8F24_04855	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H8F24_04855	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H8F24_04865	COG0415	Belongs to the DNA photolyase family
H8F24_04870	COG0189	ligase activity
H8F24_04870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8F24_04895	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H8F24_04940	COG0131	Imidazoleglycerol-phosphate dehydratase
H8F24_04950	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
H8F24_04975	COG1595	DNA-templated transcription, initiation
H8F24_04985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8F24_04990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8F24_05000	COG0354	folic acid binding
H8F24_05005	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8F24_05025	COG1028	Short-chain dehydrogenase reductase Sdr
H8F24_05080	COG2226	methyltransferase
H8F24_05105	COG2217	Heavy metal translocating P-type atpase
H8F24_05160	COG0071	Belongs to the small heat shock protein (HSP20) family
H8F24_05200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8F24_05225	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H8F24_05230	COG0511	ligase activity, forming carbon-carbon bonds
H8F24_05235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8F24_05240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8F24_05245	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H8F24_05250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8F24_05255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8F24_05260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H8F24_05265	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H8F24_05270	COG1162	GTPase activity
H8F24_05280	COG0484	heat shock protein binding
H8F24_05285	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H8F24_05290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8F24_05300	COG1459	type II secretion system
H8F24_05310	COG2081	HI0933 family
H8F24_05315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8F24_05320	COG0724	RNA recognition motif
H8F24_05325	COG0165	Argininosuccinate lyase
H8F24_05330	COG2208	phosphoserine phosphatase activity
H8F24_05335	COG0552	protein localization to endoplasmic reticulum
H8F24_05340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8F24_05355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8F24_05365	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8F24_05370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H8F24_05385	COG0592	DNA-directed DNA polymerase activity
H8F24_05390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H8F24_05400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8F24_05405	COG0497	DNA recombination
H8F24_05420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H8F24_05470	COG0438	transferase activity, transferring glycosyl groups
H8F24_05480	COG1316	TRANSCRIPTIONal
H8F24_05485	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H8F24_05500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8F24_05515	COG0137	argininosuccinate synthase activity
H8F24_05535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8F24_05540	COG0443	Heat shock 70 kDa protein
H8F24_05545	COG2022	thiamine diphosphate biosynthetic process
H8F24_05545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8F24_05555	COG0788	formyltetrahydrofolate deformylase activity
H8F24_05590	COG1049	propionate catabolic process, 2-methylcitrate cycle
H8F24_05595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8F24_05605	COG0170	dolichyl monophosphate biosynthetic process
H8F24_05610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F24_05615	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H8F24_05630	COG1053	succinate dehydrogenase
H8F24_05640	COG0315	cyclic pyranopterin monophosphate synthase activity
H8F24_05645	COG0393	Putative heavy-metal-binding
H8F24_05650	COG0303	'Molybdopterin
H8F24_05655	COG0438	transferase activity, transferring glycosyl groups
H8F24_05660	COG3100	YcgL domain-containing protein
H8F24_05660	COG0561	phosphatase activity
H8F24_05670	COG0730	response to heat
H8F24_05675	COG0314	molybdopterin synthase activity
H8F24_05685	COG0590	tRNA wobble adenosine to inosine editing
H8F24_05720	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8F24_05730	COG1597	lipid kinase activity
H8F24_05730	COG1803	Methylglyoxal synthase
H8F24_05790	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F24_05795	COG3657	addiction module killer protein
H8F24_05810	COG4974	Belongs to the 'phage' integrase family
H8F24_05845	COG2801	Transposase and inactivated derivatives
H8F24_05875	COG4584	PFAM Integrase catalytic
H8F24_05880	COG1484	DNA-dependent DNA replication
H8F24_05935	COG4974	Belongs to the 'phage' integrase family
H8F24_06000	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H8F24_06010	COG2223	nitrite transmembrane transporter activity
H8F24_06015	COG0243	molybdopterin cofactor binding
H8F24_06025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8F24_06035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8F24_06050	COG1648	precorrin-2 dehydrogenase activity
H8F24_06050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8F24_06070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F24_06070	COG0426	domain, Protein
H8F24_06080	COG0426	domain, Protein
H8F24_06080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F24_06085	COG1773	rubredoxin
H8F24_06085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F24_06105	COG0509	glycine decarboxylation via glycine cleavage system
H8F24_06110	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H8F24_06130	COG0359	binds to the 23S rRNA
H8F24_06135	COG0305	Participates in initiation and elongation during chromosome replication
H8F24_06135	COG1372	Participates in initiation and elongation during chromosome replication
H8F24_06135	COG1372	Participates in initiation and elongation during chromosome replication
H8F24_06135	COG0305	Participates in initiation and elongation during chromosome replication
H8F24_06190	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H8F24_06205	COG1473	amidohydrolase
H8F24_06225	COG1357	PFAM Pentapeptide repeats (8 copies)
H8F24_06225	COG0515	serine threonine protein kinase
H8F24_06235	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8F24_06240	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H8F24_06265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8F24_06270	COG0745	RESPONSE REGULATOR receiver
H8F24_06295	COG0629	single-stranded DNA binding
H8F24_06300	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H8F24_06305	COG0802	atpase or kinase
H8F24_06310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8F24_06340	COG0174	glutamine synthetase
H8F24_06345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F24_06350	COG2239	Acts as a magnesium transporter
H8F24_06365	COG0386	Belongs to the glutathione peroxidase family
H8F24_06370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8F24_06375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8F24_06385	COG1372	Participates in initiation and elongation during chromosome replication
H8F24_06385	COG0187	DNA topoisomerase II activity
H8F24_06390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8F24_06405	COG1725	Transcriptional regulator
H8F24_06410	COG1045	serine acetyltransferase
H8F24_06425	COG0653	protein targeting
H8F24_06430	COG0297	glycogen (starch) synthase activity
H8F24_06435	COG0454	-acetyltransferase
H8F24_06455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F24_06525	COG1215	transferase activity, transferring glycosyl groups
H8F24_06540	COG0438	transferase activity, transferring glycosyl groups
H8F24_06545	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H8F24_06550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8F24_06555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H8F24_06565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H8F24_06570	COG2082	Precorrin-8x methylmutase
H8F24_06580	COG0527	aspartate kinase activity
H8F24_06590	COG0556	nucleotide-excision repair
H8F24_06605	COG0037	tRNA processing
H8F24_06615	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H8F24_06620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8F24_06625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8F24_06630	COG0544	peptidyl-prolyl cis-trans isomerase activity
H8F24_06635	COG0740	serine-type endopeptidase activity
H8F24_06640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H8F24_06650	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H8F24_06655	COG1215	transferase activity, transferring glycosyl groups
H8F24_06665	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H8F24_06670	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H8F24_06690	COG2022	thiamine diphosphate biosynthetic process
H8F24_06710	COG0768	penicillin binding
H8F24_06725	COG0519	Catalyzes the synthesis of GMP from XMP
H8F24_06725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8F24_06840	COG1216	Glycosyl transferase, family 2
H8F24_07080	COG2026	Addiction module toxin, RelE StbE family
H8F24_07140	COG0402	S-adenosylhomocysteine deaminase activity
H8F24_07145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H8F24_07145	COG0784	Response regulator, receiver
H8F24_07155	COG1028	Short-chain dehydrogenase reductase Sdr
H8F24_07215	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H8F24_07235	COG0673	inositol 2-dehydrogenase activity
H8F24_07245	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H8F24_07255	COG2267	carboxylic ester hydrolase activity
H8F24_07260	COG0596	Alpha beta hydrolase
H8F24_07285	COG1484	DNA-dependent DNA replication
H8F24_07290	COG4584	PFAM Integrase catalytic
H8F24_07305	COG0402	S-adenosylhomocysteine deaminase activity
H8F24_07325	COG0402	S-adenosylhomocysteine deaminase activity
H8F24_07330	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H8F24_07330	COG0784	Response regulator, receiver
H8F24_07415	COG3263	regulation of cellular component size
H8F24_07440	COG2801	Transposase and inactivated derivatives
H8F24_07445	COG3039	Transposase
H8F24_07520	COG0318	PFAM AMP-dependent synthetase and ligase
H8F24_07525	COG1253	flavin adenine dinucleotide binding
H8F24_07530	COG0673	inositol 2-dehydrogenase activity
H8F24_07550	COG0343	queuine tRNA-ribosyltransferase activity
H8F24_07555	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H8F24_07575	COG0138	bifunctional purine biosynthesis protein purh
H8F24_07590	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H8F24_07595	COG1489	DNA binding
H8F24_07600	COG0728	peptidoglycan biosynthetic process
H8F24_07645	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8F24_07650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8F24_07655	COG1058	Belongs to the CinA family
H8F24_07655	COG1546	Belongs to the CinA family
H8F24_07660	COG3224	Antibiotic biosynthesis monooxygenase
H8F24_07665	COG2860	membrane
H8F24_07670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H8F24_07675	COG0066	3-isopropylmalate dehydratase activity
H8F24_07710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8F24_07715	COG0193	aminoacyl-tRNA hydrolase activity
H8F24_07730	COG4372	Transposase
H8F24_07740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F24_07750	COG0717	Belongs to the dCTP deaminase family
H8F24_07765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8F24_07780	COG0741	lytic transglycosylase activity
H8F24_07790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8F24_07805	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H8F24_07825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H8F24_07845	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H8F24_07865	COG2094	Belongs to the DNA glycosylase MPG family
H8F24_07870	COG0540	Belongs to the ATCase OTCase family
H8F24_07885	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H8F24_07930	COG3536	Protein conserved in bacteria
H8F24_07935	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8F24_07950	COG0529	Catalyzes the synthesis of activated sulfate
H8F24_07950	COG2046	Belongs to the sulfate adenylyltransferase family
H8F24_07955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F24_07960	COG0800	Aldolase
H8F24_07965	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H8F24_08000	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8F24_08005	COG3119	arylsulfatase activity
H8F24_08020	COG3386	PFAM SMP-30 Gluconolaconase
H8F24_08050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H8F24_08055	COG0436	Aminotransferase
H8F24_08065	COG1530	ribonuclease E activity
H8F24_08070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8F24_08080	COG0077	Prephenate dehydratase
H8F24_08080	COG1605	Chorismate mutase
H8F24_08085	COG2226	methyltransferase
H8F24_08095	COG0051	transcription antitermination factor activity, RNA binding
H8F24_08100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8F24_08105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H8F24_08110	COG0049	tRNA binding
H8F24_08115	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H8F24_08130	COG0069	glutamate synthase activity
H8F24_08130	COG0067	glutamate synthase
H8F24_08130	COG0070	glutamate synthase
H8F24_08135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8F24_08145	COG5002	protein histidine kinase activity
H8F24_08145	COG5001	Diguanylate cyclase
H8F24_08145	COG3447	MASE1 domain protein
H8F24_08165	COG2885	chlorophyll binding
H8F24_08170	COG2885	chlorophyll binding
H8F24_08185	COG0463	Glycosyl transferase, family 2
H8F24_08205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8F24_08215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H8F24_08225	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H8F24_08230	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H8F24_08235	COG0101	tRNA pseudouridine synthase activity
H8F24_08245	COG0202	RNA polymerase activity
H8F24_08250	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H8F24_08255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H8F24_08260	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H8F24_08265	COG0563	adenylate kinase activity
H8F24_08270	COG0201	protein transport
H8F24_08275	COG0200	Binds to the 23S rRNA
H8F24_08280	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H8F24_08285	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H8F24_08290	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H8F24_08295	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H8F24_08300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H8F24_08305	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H8F24_08310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H8F24_08315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H8F24_08320	COG0255	Belongs to the universal ribosomal protein uL29 family
H8F24_08330	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H8F24_08335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H8F24_08340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H8F24_08350	COG0089	rRNA binding
H8F24_08355	COG0088	Forms part of the polypeptide exit tunnel
H8F24_08360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H8F24_08375	COG3854	ATPases associated with a variety of cellular activities
H8F24_08420	COG3001	Fructosamine kinase
H8F24_08445	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H8F24_08450	COG1606	tRNA processing
H8F24_08460	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H8F24_08465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8F24_08480	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H8F24_08485	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H8F24_08490	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8F24_08500	COG2205	protein histidine kinase activity
H8F24_08505	COG0772	Belongs to the SEDS family
H8F24_08510	COG0489	protein tyrosine kinase activity
H8F24_08515	COG0408	coproporphyrinogen oxidase activity
H8F24_08560	COG0667	Aldo Keto reductase
H8F24_08570	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H8F24_08575	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8F24_08580	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H8F24_08580	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H8F24_08585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8F24_08590	COG1413	lyase activity
H8F24_08625	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8F24_08640	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F24_08675	COG1070	Carbohydrate kinase
H8F24_08680	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H8F24_08690	COG0539	negative regulation of cytoplasmic translation
H8F24_08695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H8F24_08720	COG0589	response to stress
H8F24_08730	COG0758	DNA mediated transformation
H8F24_08735	COG2890	protein-(glutamine-N5) methyltransferase activity
H8F24_08740	COG0009	L-threonylcarbamoyladenylate synthase
H8F24_08750	COG3706	GGDEF domain
H8F24_08755	COG2203	Gaf domain
H8F24_08755	COG3706	GGDEF domain
H8F24_08755	COG4251	negative regulation of phosphorylation
H8F24_08755	COG5001	Diguanylate cyclase
H8F24_08780	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H8F24_08785	COG2894	cell division
H8F24_08800	COG2059	Chromate
H8F24_08805	COG0850	regulation of cytokinetic process
H8F24_08810	COG1078	dGTPase activity
H8F24_08815	COG0793	Belongs to the peptidase S41A family
H8F24_08820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8F24_08825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8F24_08880	COG1570	exodeoxyribonuclease VII activity
H8F24_08890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F24_08900	COG1643	Atp-dependent helicase
H8F24_08915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8F24_08930	COG0488	(ABC) transporter
H8F24_08960	COG0569	domain protein
H8F24_08965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H8F24_08970	COG0450	alkyl hydroperoxide reductase
H8F24_08975	COG0471	metal ion transport
H8F24_08975	COG3273	potassium ion transport
H8F24_08980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8F24_08990	COG1252	NADH dehydrogenase
H8F24_08995	COG0175	sulfate reduction
H8F24_09000	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H8F24_09005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8F24_09025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F24_09030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8F24_09065	COG0033	Phosphoglucomutase
H8F24_09090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8F24_09105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F24_09125	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
H8F24_09130	COG0719	Fe-S assembly protein
H8F24_09135	COG0396	ATPase activity
H8F24_09140	COG0719	Fe-S assembly protein
H8F24_09145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8F24_09175	COG2197	response regulator
H8F24_09185	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H8F24_09200	COG1028	Short-chain dehydrogenase reductase Sdr
H8F24_09200	COG3347	Dehydrogenase
H8F24_09270	COG0562	UDP-galactopyranose mutase
H8F24_09320	COG3328	transposase activity
H8F24_09365	COG3328	transposase activity
H8F24_09395	COG3328	transposase activity
H8F24_09435	COG3328	transposase activity
H8F24_09465	COG0242	peptide deformylase activity
H8F24_09480	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H8F24_09495	COG0537	adenosine 5'-monophosphoramidase activity
H8F24_09500	COG4178	(ABC) transporter
H8F24_09520	COG0515	serine threonine protein kinase
H8F24_09535	COG0439	Biotin carboxylase
H8F24_09545	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F24_09550	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F24_09560	COG1196	nuclear chromosome segregation
H8F24_09575	COG0116	Belongs to the methyltransferase superfamily
H8F24_09620	COG3550	peptidyl-serine autophosphorylation
H8F24_09645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8F24_09645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8F24_09650	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8F24_09660	COG3328	transposase activity
H8F24_09750	COG0202	RNA polymerase activity
H8F24_09760	COG2801	Transposase and inactivated derivatives
H8F24_09780	COG0443	Heat shock 70 kDa protein
H8F24_09790	COG2361	Protein of unknown function DUF86
H8F24_09800	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H8F24_09880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F24_09895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F24_09935	COG2801	Transposase and inactivated derivatives
H8F24_09950	COG0297	glycogen (starch) synthase activity
H8F24_09955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8F24_09960	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8F24_09970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H8F24_09980	COG0740	serine-type endopeptidase activity
H8F24_09985	COG0740	serine-type endopeptidase activity
H8F24_09990	COG4956	integral membrane protein (PIN domain superfamily)
H8F24_09995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8F24_10000	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H8F24_10010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H8F24_10025	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8F24_10030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8F24_10035	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H8F24_10035	COG2066	Belongs to the glutaminase family
H8F24_10040	COG4948	Mandelate Racemase Muconate Lactonizing
H8F24_10085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8F24_10090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8F24_10095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8F24_10110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8F24_10115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8F24_10120	COG0134	indole-3-glycerol-phosphate synthase activity
H8F24_10125	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H8F24_10130	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H8F24_10140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8F24_10145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H8F24_10170	COG0306	phosphate transporter
H8F24_10190	COG0706	membrane insertase activity
H8F24_10200	COG0594	ribonuclease P activity
H8F24_10205	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H8F24_10220	COG0616	signal peptide processing
H8F24_10225	COG0697	spore germination
H8F24_10230	COG0438	transferase activity, transferring glycosyl groups
H8F24_10245	COG1842	Phage shock protein A
H8F24_10250	COG3118	belongs to the thioredoxin family
H8F24_10255	COG0436	Aminotransferase
H8F24_10260	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H8F24_10260	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H8F24_10265	COG0739	heme binding
H8F24_10270	COG1136	(ABC) transporter
H8F24_10280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8F24_10295	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H8F24_10335	COG1845	cytochrome c oxidase, subunit III
H8F24_10340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8F24_10355	COG0109	protoheme IX farnesyltransferase activity
H8F24_10370	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H8F24_10375	COG0459	protein refolding
H8F24_10385	COG1028	Short-chain dehydrogenase reductase Sdr
H8F24_10390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8F24_10400	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H8F24_10410	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8F24_10425	COG0482	sulfurtransferase activity
H8F24_10430	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H8F24_10430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8F24_10435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F24_10440	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8F24_10450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H8F24_10460	COG1702	phosphate starvation-inducible protein PhoH
H8F24_10465	COG0670	Belongs to the BI1 family
H8F24_10475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H8F24_10485	COG0336	Belongs to the RNA methyltransferase TrmD family
H8F24_10495	COG1691	(AIR) carboxylase
H8F24_10515	COG0196	riboflavin kinase activity
H8F24_10525	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H8F24_10530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H8F24_10535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8F24_10540	COG0745	RESPONSE REGULATOR receiver
H8F24_10555	COG0651	ATP synthesis coupled electron transport
H8F24_10605	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8F24_10605	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8F24_10610	COG0668	transmembrane transport
H8F24_10625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F24_10630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8F24_10635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8F24_10665	COG2154	pterin-4-alpha-carbinolamine dehydratase
H8F24_10695	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H8F24_10725	COG1185	polyribonucleotide nucleotidyltransferase activity
H8F24_10730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H8F24_10735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H8F24_10740	COG0750	zinc metalloprotease
H8F24_10745	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H8F24_10750	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H8F24_10800	COG0347	Belongs to the P(II) protein family
H8F24_10810	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H8F24_10835	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_10845	COG0586	Pfam SNARE associated Golgi protein
H8F24_10855	COG2205	protein histidine kinase activity
H8F24_10865	COG1126	abc transporter atp-binding protein
H8F24_10870	COG0765	amino acid transport
H8F24_10875	COG4597	amino acid ABC transporter
H8F24_10880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8F24_10885	COG0530	calcium, potassium:sodium antiporter activity
H8F24_10890	COG0371	Dehydrogenase
H8F24_10895	COG0596	Alpha beta hydrolase
H8F24_10930	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H8F24_10940	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H8F24_10945	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H8F24_10950	COG0298	carbon dioxide binding
H8F24_10955	COG0674	pyruvate-flavodoxin oxidoreductase activity
H8F24_10955	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H8F24_10955	COG1013	pyruvate-flavodoxin oxidoreductase activity
H8F24_10955	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H8F24_10960	COG0167	dihydroorotate dehydrogenase activity
H8F24_10965	COG0409	Hydrogenase expression formation protein
H8F24_10980	COG0579	oxidoreductase
H8F24_10990	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H8F24_10995	COG0739	heme binding
H8F24_11000	COG0723	plastoquinol--plastocyanin reductase activity
H8F24_11010	COG0805	protein transport
H8F24_11015	COG1293	RNA-binding protein homologous to eukaryotic snRNP
H8F24_11020	COG0194	GDP metabolic process
H8F24_11035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H8F24_11040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F24_11050	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H8F24_11060	COG0012	GTP binding
H8F24_11095	COG0601	transmembrane transport
H8F24_11110	COG0460	homoserine dehydrogenase
H8F24_11115	COG2166	iron-sulfur cluster assembly
H8F24_11125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8F24_11130	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H8F24_11135	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H8F24_11155	COG2010	Cytochrome c
H8F24_11170	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8F24_11175	COG1611	Belongs to the LOG family
H8F24_11180	COG3118	belongs to the thioredoxin family
H8F24_11185	COG0516	GMP reductase activity
H8F24_11200	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8F24_11205	COG0644	oxidoreductase
H8F24_11210	COG1543	Belongs to the glycosyl hydrolase 57 family
H8F24_11220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8F24_11225	COG0395	ABC-type sugar transport system, permease component
H8F24_11245	COG1480	7TM receptor with intracellular HD hydrolase
H8F24_11260	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
H8F24_11280	COG1254	Belongs to the acylphosphatase family
H8F24_11285	COG1797	cobyrinic acid a,c-diamide synthase activity
H8F24_11290	COG3429	Glucose-6-phosphate dehydrogenase subunit
H8F24_11290	COG3409	Peptidoglycan-binding domain 1 protein
H8F24_11295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8F24_11320	COG2205	protein histidine kinase activity
H8F24_11335	COG0308	aminopeptidase N
H8F24_11345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H8F24_11360	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
H8F24_11365	COG1640	4-alpha-glucanotransferase
H8F24_11375	COG1187	pseudouridine synthase activity
H8F24_11380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F24_11390	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8F24_11395	COG1982	Orn Lys Arg decarboxylase major
H8F24_11400	COG2242	protein methyltransferase activity
H8F24_11400	COG2241	protein methyltransferase activity
H8F24_11405	COG0575	Belongs to the CDS family
H8F24_11435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8F24_11450	COG0375	protein maturation
H8F24_11460	COG3259	Nickel-dependent hydrogenase
H8F24_11490	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_11540	COG0776	regulation of translation
H8F24_11550	COG1523	belongs to the glycosyl hydrolase 13 family
H8F24_11570	COG1215	transferase activity, transferring glycosyl groups
H8F24_11575	COG1472	Belongs to the glycosyl hydrolase 3 family
H8F24_11645	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H8F24_11655	COG1064	alcohol dehydrogenase
H8F24_11660	COG1233	COG1233 Phytoene dehydrogenase and related
H8F24_11685	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8F24_11690	COG0271	Belongs to the BolA IbaG family
H8F24_11705	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H8F24_11720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H8F24_11730	COG1074	ATP-dependent DNA helicase activity
H8F24_11735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F24_11745	COG0513	Belongs to the DEAD box helicase family
H8F24_11755	COG0724	RNA recognition motif
H8F24_11775	COG1132	(ABC) transporter
H8F24_11830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H8F24_11835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8F24_11840	COG2205	protein histidine kinase activity
H8F24_11845	COG0745	RESPONSE REGULATOR receiver
H8F24_11860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8F24_11865	COG3695	enzyme binding
H8F24_11870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8F24_11870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8F24_11875	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8F24_11880	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8F24_11890	COG0107	imidazoleglycerol-phosphate synthase activity
H8F24_11900	COG2226	methyltransferase
H8F24_11905	COG0752	glycyl-tRNA synthetase alpha subunit
H8F24_11925	COG0582	viral genome integration into host DNA
H8F24_12085	COG5002	protein histidine kinase activity
H8F24_12090	COG0745	RESPONSE REGULATOR receiver
H8F24_12235	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F24_12290	COG2217	Heavy metal translocating P-type atpase
H8F24_12320	COG0789	Transcriptional regulator
H8F24_12355	COG2442	InterPro IPR007367
H8F24_12390	COG2267	carboxylic ester hydrolase activity
H8F24_12410	COG1484	DNA-dependent DNA replication
H8F24_12415	COG4584	PFAM Integrase catalytic
H8F24_12505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8F24_12515	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8F24_12530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F24_12555	COG0121	glutamine amidotransferase
H8F24_12565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8F24_12570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8F24_12620	COG2226	methyltransferase
H8F24_12625	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F24_12645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F24_12655	COG1136	(ABC) transporter
H8F24_12655	COG0577	efflux transmembrane transporter activity
H8F24_12685	COG4584	PFAM Integrase catalytic
H8F24_12760	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H8F24_12785	COG3328	transposase activity
H8F24_12810	COG1054	Belongs to the UPF0176 family
H8F24_12815	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H8F24_12820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8F24_12825	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H8F24_12830	COG0019	diaminopimelate decarboxylase activity
H8F24_12840	COG0542	response to heat
H8F24_12895	COG0724	RNA recognition motif
H8F24_12920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8F24_12970	COG0531	amino acid
H8F24_12995	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8F24_13065	COG2211	Major facilitator Superfamily
H8F24_13070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8F24_13085	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H8F24_13090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H8F24_13095	COG1799	cell septum assembly
H8F24_13100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8F24_13110	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H8F24_13115	COG1160	GTP binding
H8F24_13125	COG0477	Major facilitator Superfamily
H8F24_13140	COG3527	Alpha-acetolactate decarboxylase
H8F24_13145	COG0028	Belongs to the TPP enzyme family
H8F24_13160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8F24_13170	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H8F24_13175	COG2918	glutathione biosynthetic process
H8F24_13175	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8F24_13190	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H8F24_13205	COG0438	transferase activity, transferring glycosyl groups
H8F24_13220	COG1381	Involved in DNA repair and RecF pathway recombination
H8F24_13225	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H8F24_13230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H8F24_13235	COG0321	lipoyl(octanoyl) transferase activity
H8F24_13240	COG1022	Amp-dependent synthetase and ligase
H8F24_13255	COG0531	amino acid
H8F24_13260	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H8F24_13265	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8F24_13280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H8F24_13285	COG1492	cobalamin metabolic process
H8F24_13295	COG0424	maF-like protein
H8F24_13325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8F24_13330	COG0440	acetolactate synthase activity
H8F24_13335	COG2267	carboxylic ester hydrolase activity
H8F24_13340	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H8F24_13385	COG1187	pseudouridine synthase activity
H8F24_13390	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H8F24_13395	COG0492	ferredoxin-NADP+ reductase activity
H8F24_13425	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H8F24_13450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8F24_13460	COG0733	neurotransmitter:sodium symporter activity
H8F24_13515	COG0489	protein tyrosine kinase activity
H8F24_13575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8F24_13590	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H8F24_13635	COG0438	transferase activity, transferring glycosyl groups
H8F24_13650	COG0438	transferase activity, transferring glycosyl groups
H8F24_13660	COG0367	asparagine synthase
H8F24_13680	COG0438	transferase activity, transferring glycosyl groups
H8F24_13685	COG0110	maltose O-acetyltransferase activity
H8F24_13725	COG0656	L-ascorbic acid biosynthetic process
H8F24_13740	COG3039	Transposase
H8F24_13760	COG2942	2-epimerase
H8F24_13765	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H8F24_13765	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H8F24_13770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8F24_13775	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H8F24_13815	COG0297	glycogen (starch) synthase activity
H8F24_13820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8F24_13935	COG0215	cysteine-tRNA ligase activity
H8F24_13940	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H8F24_13945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8F24_13955	COG0475	glutathione-regulated potassium exporter activity
H8F24_13955	COG0589	response to stress
H8F24_13990	COG0367	asparagine synthase
H8F24_13995	COG0540	Belongs to the ATCase OTCase family
H8F24_14025	COG0799	negative regulation of ribosome biogenesis
H8F24_14035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8F24_14045	COG1115	amino acid carrier protein
H8F24_14060	COG1132	(ABC) transporter
H8F24_14065	COG2501	S4 domain
H8F24_14070	COG0149	triose-phosphate isomerase activity
H8F24_14075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8F24_14090	COG1132	(ABC) transporter
H8F24_14095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F24_14115	COG0745	RESPONSE REGULATOR receiver
H8F24_14120	COG1429	ligase activity, forming nitrogen-metal bonds
H8F24_14125	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H8F24_14135	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F24_14140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8F24_14150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8F24_14220	COG0598	Magnesium transport protein CorA
H8F24_14240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F24_14245	COG0745	RESPONSE REGULATOR receiver
H8F24_14250	COG5002	protein histidine kinase activity
H8F24_14255	COG0659	secondary active sulfate transmembrane transporter activity
H8F24_14265	COG0659	secondary active sulfate transmembrane transporter activity
H8F24_14270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H8F24_14285	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8F24_14295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8F24_14315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8F24_14340	COG3128	pkhd-type hydroxylase
H8F24_14350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8F24_14365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8F24_14380	COG2199	diguanylate cyclase activity
H8F24_14390	COG0358	DNA primase activity
H8F24_14405	COG0632	four-way junction helicase activity
H8F24_14410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H8F24_14420	COG0587	DNA-directed DNA polymerase activity
H8F24_14425	COG0154	amidase activity
H8F24_14440	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H8F24_14450	COG0505	Belongs to the CarA family
H8F24_14455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8F24_14465	COG1132	(ABC) transporter
H8F24_14475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F24_14510	COG0505	Belongs to the CarA family
H8F24_14525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8F24_14555	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8F24_14560	COG0798	PFAM Bile acid sodium symporter
H8F24_14595	COG3551	Protein conserved in bacteria
H8F24_14645	COG3321	synthase
H8F24_14645	COG0604	alcohol dehydrogenase
H8F24_14655	COG2801	Transposase and inactivated derivatives
H8F24_14725	COG4584	PFAM Integrase catalytic
H8F24_14730	COG1484	DNA-dependent DNA replication
H8F24_14785	COG1484	DNA-dependent DNA replication
H8F24_14845	COG3328	transposase activity
H8F24_14890	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H8F24_14895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8F24_14910	COG2345	Transcriptional regulator
H8F24_14915	COG0154	amidase activity
H8F24_14950	COG2197	response regulator
H8F24_15000	COG2326	polyphosphate kinase activity
H8F24_15010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8F24_15015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8F24_15055	COG0142	geranyltranstransferase activity
H8F24_15060	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H8F24_15075	COG2045	Belongs to the ComB family
H8F24_15080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H8F24_15085	COG1959	2 iron, 2 sulfur cluster binding
H8F24_15095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H8F24_15100	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H8F24_15100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8F24_15105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F24_15115	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8F24_15125	COG0297	glycogen (starch) synthase activity
H8F24_15130	COG1376	ErfK ybiS ycfS ynhG family protein
H8F24_15135	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H8F24_15140	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H8F24_15145	COG0681	Belongs to the peptidase S26 family
H8F24_15160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8F24_15165	COG1121	(ABC) transporter
H8F24_15200	COG0180	Tryptophanyl-tRNA synthetase
H8F24_15220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8F24_15225	COG0837	glucose binding
H8F24_15230	COG0083	homoserine kinase activity
H8F24_15235	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_15240	COG0339	signal peptide processing
H8F24_15255	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H8F24_15260	COG1940	carbohydrate kinase activity
H8F24_15295	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8F24_15300	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H8F24_15310	COG2010	Cytochrome c
H8F24_15335	COG0542	response to heat
H8F24_15340	COG0432	Pfam Uncharacterised protein family UPF0047
H8F24_15355	COG1283	sodium-dependent phosphate transmembrane transporter activity
H8F24_15385	COG1741	Belongs to the pirin family
H8F24_15390	COG0281	malic enzyme
H8F24_15415	COG4942	peptidase
H8F24_15425	COG0347	Belongs to the P(II) protein family
H8F24_15430	COG0004	ammonium transporteR
H8F24_15445	COG0792	nuclease activity
H8F24_15455	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H8F24_15460	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H8F24_15470	COG0022	dehydrogenase e1 component
H8F24_15475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8F24_15480	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8F24_15495	COG0628	permease
H8F24_15500	COG3310	Protein conserved in bacteria
H8F24_15505	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H8F24_15510	COG0515	serine threonine protein kinase
H8F24_15530	COG2226	methyltransferase
H8F24_15535	COG0174	glutamine synthetase
H8F24_15545	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H8F24_15550	COG0590	tRNA wobble adenosine to inosine editing
H8F24_15550	COG0037	tRNA processing
H8F24_15565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8F24_15570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H8F24_15590	COG0612	Peptidase, M16
H8F24_15610	COG1136	(ABC) transporter
H8F24_15620	COG1216	Glycosyl transferase, family 2
H8F24_15625	COG0052	Belongs to the universal ribosomal protein uS2 family
H8F24_15630	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H8F24_15640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8F24_15645	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H8F24_15655	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8F24_15660	COG0751	glycine-tRNA ligase activity
H8F24_15665	COG0644	oxidoreductase
H8F24_15675	COG0826	peptidase U32
H8F24_15680	COG1217	gtp-binding protein TYPA
H8F24_15695	COG1137	ATPase activity
H8F24_15705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8F24_15710	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H8F24_15715	COG1494	fructose-1,6-bisphosphatase
H8F24_15720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H8F24_15725	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F24_15730	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H8F24_15735	COG0363	glucosamine-6-phosphate deaminase activity
H8F24_15750	COG0129	dihydroxy-acid dehydratase activity
H8F24_15760	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H8F24_15790	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8F24_15795	COG0047	phosphoribosylformylglycinamidine synthase activity
H8F24_15800	COG1619	proteins homologs of microcin C7 resistance protein MccF
H8F24_15805	COG0450	alkyl hydroperoxide reductase
H8F24_15825	COG0484	heat shock protein binding
H8F24_15830	COG0076	glutamate decarboxylase activity
H8F24_15835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F24_15840	COG0640	Transcriptional regulator
H8F24_15845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8F24_15900	COG1695	Transcriptional regulator
H8F24_15945	COG2361	Protein of unknown function DUF86
H8F24_15980	COG1487	ribonuclease activity
H8F24_16075	COG2105	PFAM AIG2 family protein
H8F24_16090	COG0739	heme binding
H8F24_16095	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H8F24_16130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8F24_16145	COG0557	exoribonuclease II activity
H8F24_16150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8F24_16155	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H8F24_16160	COG0072	phenylalanine-tRNA ligase activity
H8F24_16160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8F24_16165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8F24_16195	COG2385	sporulation resulting in formation of a cellular spore
H8F24_16205	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H8F24_16230	COG0646	methionine synthase
H8F24_16230	COG1410	methionine synthase
H8F24_16235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8F24_16255	COG1981	membrane
H8F24_16265	COG0641	radical SAM
H8F24_16295	COG3046	protein related to deoxyribodipyrimidine photolyase
H8F24_16305	COG0322	excinuclease ABC activity
H8F24_16315	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H8F24_16325	COG2027	D-alanyl-D-alanine carboxypeptidase
H8F24_16340	COG1104	cysteine desulfurase activity
H8F24_16345	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H8F24_16355	COG0495	leucyl-tRNA aminoacylation
H8F24_16360	COG0166	Belongs to the GPI family
H8F24_16385	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H8F24_16390	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H8F24_16395	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H8F24_16395	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H8F24_16400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8F24_16405	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H8F24_16410	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H8F24_16420	COG0484	heat shock protein binding
H8F24_16425	COG0443	Heat shock 70 kDa protein
H8F24_16430	COG0573	inorganic phosphate transmembrane transporter activity
H8F24_16435	COG0581	inorganic phosphate transmembrane transporter activity
H8F24_16440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8F24_16455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8F24_16460	COG0483	inositol monophosphate 1-phosphatase activity
H8F24_16465	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H8F24_16480	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H8F24_16485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8F24_16525	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H8F24_16530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8F24_16560	COG0469	pyruvate kinase activity
H8F24_16565	COG1136	(ABC) transporter
H8F24_16565	COG0577	efflux transmembrane transporter activity
H8F24_16575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F24_16580	COG0740	serine-type endopeptidase activity
H8F24_16600	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H8F24_16660	COG3328	transposase activity
H8F24_16715	COG4584	PFAM Integrase catalytic
H8F24_16790	COG2801	Transposase and inactivated derivatives
H8F24_16795	COG2801	Transposase and inactivated derivatives
H8F24_16815	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H8F24_16820	COG1175	transmembrane transport
H8F24_16825	COG0514	ATP-dependent DNA helicase (RecQ)
H8F24_16830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H8F24_16870	COG3588	fructose-bisphosphate aldolase
H8F24_16875	COG1793	dna ligase
H8F24_16875	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8F24_16900	COG0778	Nitroreductase
H8F24_16930	COG0569	domain protein
H8F24_16930	COG0475	glutathione-regulated potassium exporter activity
H8F24_16935	COG1028	Short-chain dehydrogenase reductase Sdr
H8F24_16950	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H8F24_16975	COG0861	Integral membrane protein TerC family
H8F24_16985	COG0513	Belongs to the DEAD box helicase family
H8F24_17000	COG1252	NADH dehydrogenase
H8F24_17005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8F24_17015	COG0312	modulator of DNA gyrase
H8F24_17020	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H8F24_17035	COG0163	prenyltransferase activity
H8F24_17040	COG0557	exoribonuclease II activity
H8F24_17075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H8F24_17075	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H8F24_17095	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H8F24_17100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F24_17115	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H8F24_17120	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H8F24_17130	COG0191	fructose-bisphosphate aldolase activity
H8F24_17135	COG0673	inositol 2-dehydrogenase activity
H8F24_17145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H8F24_17150	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H8F24_17160	COG3954	Phosphoribulokinase
H8F24_17165	COG0473	3-isopropylmalate dehydrogenase activity
H8F24_17170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F24_17175	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8F24_17190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H8F24_17205	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H8F24_17215	COG5001	Diguanylate cyclase
H8F24_17215	COG5002	protein histidine kinase activity
H8F24_17215	COG3447	MASE1 domain protein
H8F24_17220	COG0114	fumarate hydratase activity
H8F24_17225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8F24_17230	COG2197	response regulator
H8F24_17240	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H8F24_17260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8F24_17290	COG1201	RNA secondary structure unwinding
H8F24_17295	COG1793	dna ligase
H8F24_17295	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8F24_17300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F24_17325	COG1136	(ABC) transporter
H8F24_17325	COG0577	efflux transmembrane transporter activity
H8F24_17350	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8F24_17400	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H8F24_17460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8F24_17470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8F24_17485	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
H8F24_17495	COG4245	von Willebrand factor, type A
H8F24_17505	COG2234	aminopeptidase activity
H8F24_17520	COG4456	Virulence-associated protein
H8F24_17570	COG1160	GTP binding
H8F24_17705	COG1484	DNA-dependent DNA replication
H8F24_17710	COG4584	PFAM Integrase catalytic
H8F24_17745	COG1028	Short-chain dehydrogenase reductase Sdr
H8F24_17820	COG1122	ATPase activity
H8F24_17860	COG0159	tryptophan synthase activity
H8F24_17880	COG2010	Cytochrome c
H8F24_17920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F24_17935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8F24_17940	COG1121	(ABC) transporter
H8F24_17955	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H8F24_17955	COG0140	phosphoribosyl-ATP diphosphatase activity
H8F24_17960	COG0720	synthase
H8F24_17965	COG0701	Predicted permease
H8F24_17985	COG3659	wide pore channel activity
H8F24_18000	COG3706	GGDEF domain
H8F24_18010	COG0523	cobalamin synthesis protein
H8F24_18025	COG1840	ABC-type Fe3 transport system, periplasmic component
H8F24_18045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F24_18050	COG0735	belongs to the Fur family
H8F24_18090	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
H8F24_18095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F24_18115	COG0708	Exodeoxyribonuclease III
H8F24_18125	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H8F24_18130	COG4251	negative regulation of phosphorylation
H8F24_18145	COG2119	membrane
H8F24_18155	COG1116	anion transmembrane transporter activity
H8F24_18160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8F24_18180	COG0375	protein maturation
H8F24_18185	COG0010	Belongs to the arginase family
H8F24_18205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8F24_18220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8F24_18220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8F24_18235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8F24_18250	COG0335	large ribosomal subunit rRNA binding
H8F24_18260	COG0024	Methionine aminopeptidase
H8F24_18265	COG0300	oxidoreductase activity
H8F24_18265	COG3000	fatty acid hydroxylase
H8F24_18275	COG0857	belongs to the CobB CobQ family
H8F24_18290	COG0330	HflC and HflK could
H8F24_18315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F24_18325	COG1666	GTP binding
H8F24_18375	COG0405	Gamma-glutamyltransferase
H8F24_18405	COG1845	cytochrome c oxidase, subunit III
H8F24_18480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8F24_18485	COG0277	FAD linked oxidase domain protein
H8F24_18545	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8F24_18550	COG4106	trans-aconitate 2-methyltransferase activity
H8F24_18565	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H8F24_18580	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H8F24_18585	COG1122	ATPase activity
H8F24_18605	COG1836	PFAM Integral membrane protein DUF92
H8F24_18620	COG3639	organic phosphonate transmembrane transporter activity
H8F24_18625	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H8F24_18645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8F24_18655	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H8F24_18660	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H8F24_18670	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H8F24_18675	COG0436	Aminotransferase
H8F24_18695	COG1573	uracil-dna glycosylase
H8F24_18710	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H8F24_18715	COG0793	Belongs to the peptidase S41A family
H8F24_18730	COG1269	ATP hydrolysis coupled proton transport
H8F24_18750	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
H8F24_18760	COG0668	transmembrane transport
H8F24_18765	COG1196	nuclear chromosome segregation
H8F24_18765	COG3264	Mechanosensitive ion channel
H8F24_18800	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H8F24_18845	COG1230	cation diffusion facilitator family transporter
H8F24_18850	COG0300	oxidoreductase activity
H8F24_18865	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8F24_18865	COG0284	orotidine-5'-phosphate decarboxylase activity
H8F24_18870	COG0418	dihydroorotase activity
H8F24_18880	COG0251	oxidation-reduction process
H8F24_18885	COG3842	ATPase activity
H8F24_18890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8F24_18895	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H8F24_18900	COG1132	(ABC) transporter
H8F24_18910	COG0456	acetyltransferase
H8F24_18915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain