locus-tag	class	description
I1E95_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I1E95_00010	COG0464	growth
I1E95_00025	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_00030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I1E95_00040	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I1E95_00065	COG4451	ribulose bisphosphate carboxylase, small
I1E95_00070	COG1850	ribulose-bisphosphate carboxylase activity
I1E95_00075	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I1E95_00080	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
I1E95_00085	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
I1E95_00090	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
I1E95_00130	COG0730	response to heat
I1E95_00135	COG0095	Lipoate-protein ligase
I1E95_00140	COG0517	IMP dehydrogenase activity
I1E95_00140	COG1994	Peptidase M50
I1E95_00145	COG0135	phosphoribosylanthranilate isomerase activity
I1E95_00155	COG4221	oxidoreductase activity
I1E95_00160	COG0825	malonyl-CoA metabolic process
I1E95_00165	COG5322	oxidoreductase activity
I1E95_00170	COG3396	Phenylacetate-CoA oxygenase
I1E95_00180	COG0539	negative regulation of cytoplasmic translation
I1E95_00195	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I1E95_00210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1E95_00215	COG0745	RESPONSE REGULATOR receiver
I1E95_00245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I1E95_00250	COG0530	calcium, potassium:sodium antiporter activity
I1E95_00255	COG0659	secondary active sulfate transmembrane transporter activity
I1E95_00260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1E95_00270	COG0523	cobalamin synthesis protein
I1E95_00275	COG3659	wide pore channel activity
I1E95_00300	COG2132	Multicopper oxidase
I1E95_00310	COG1121	(ABC) transporter
I1E95_00315	COG3328	transposase activity
I1E95_00325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I1E95_00340	COG0701	Predicted permease
I1E95_00350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I1E95_00350	COG0140	phosphoribosyl-ATP diphosphatase activity
I1E95_00370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1E95_00375	COG3339	Conserved Protein
I1E95_00410	COG2010	Cytochrome c
I1E95_00440	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I1E95_00450	COG0159	tryptophan synthase activity
I1E95_00480	COG3328	transposase activity
I1E95_00485	COG4221	oxidoreductase activity
I1E95_00485	COG3321	synthase
I1E95_00485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1E95_00485	COG0300	oxidoreductase activity
I1E95_00495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I1E95_00505	COG0242	peptide deformylase activity
I1E95_00515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I1E95_00520	COG0463	Glycosyl transferase, family 2
I1E95_00535	COG0415	Belongs to the DNA photolyase family
I1E95_00545	COG0659	secondary active sulfate transmembrane transporter activity
I1E95_00610	COG2226	methyltransferase
I1E95_00615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I1E95_00630	COG0668	transmembrane transport
I1E95_00670	COG3328	transposase activity
I1E95_00705	COG0586	Pfam SNARE associated Golgi protein
I1E95_00725	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I1E95_00730	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I1E95_00775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_00780	COG1231	oxidoreductase activity
I1E95_00810	COG0786	glutamate:sodium symporter activity
I1E95_00815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I1E95_00835	COG0739	heme binding
I1E95_00865	COG1054	Belongs to the UPF0176 family
I1E95_00870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I1E95_00875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I1E95_00880	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I1E95_00885	COG0019	diaminopimelate decarboxylase activity
I1E95_00895	COG0542	response to heat
I1E95_00900	COG0371	Dehydrogenase
I1E95_00905	COG2226	methyltransferase
I1E95_00905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I1E95_00905	COG0596	Alpha beta hydrolase
I1E95_00920	COG0575	Belongs to the CDS family
I1E95_00930	COG1982	Orn Lys Arg decarboxylase major
I1E95_00935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I1E95_00955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1E95_00960	COG1187	pseudouridine synthase activity
I1E95_00970	COG1640	4-alpha-glucanotransferase
I1E95_00975	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
I1E95_00990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I1E95_01000	COG0308	aminopeptidase N
I1E95_01020	COG2205	protein histidine kinase activity
I1E95_01040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I1E95_01045	COG3429	Glucose-6-phosphate dehydrogenase subunit
I1E95_01045	COG3409	Peptidoglycan-binding domain 1 protein
I1E95_01050	COG1797	cobyrinic acid a,c-diamide synthase activity
I1E95_01055	COG1254	Belongs to the acylphosphatase family
I1E95_01080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I1E95_01085	COG1480	7TM receptor with intracellular HD hydrolase
I1E95_01090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_01125	COG0799	negative regulation of ribosome biogenesis
I1E95_01135	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I1E95_01155	COG1132	(ABC) transporter
I1E95_01165	COG0149	triose-phosphate isomerase activity
I1E95_01170	COG0277	FAD linked oxidase domain protein
I1E95_01175	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I1E95_01185	COG0559	Belongs to the binding-protein-dependent transport system permease family
I1E95_01215	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I1E95_01220	COG2045	Belongs to the ComB family
I1E95_01235	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I1E95_01240	COG0142	geranyltranstransferase activity
I1E95_01260	COG4106	trans-aconitate 2-methyltransferase activity
I1E95_01350	COG3046	protein related to deoxyribodipyrimidine photolyase
I1E95_01370	COG3328	transposase activity
I1E95_01390	COG1881	PFAM PEBP family protein
I1E95_01490	COG3328	transposase activity
I1E95_01495	COG5002	protein histidine kinase activity
I1E95_01510	COG3588	fructose-bisphosphate aldolase
I1E95_01530	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I1E95_01530	COG1793	dna ligase
I1E95_01600	COG1793	dna ligase
I1E95_01610	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I1E95_01630	COG1201	RNA secondary structure unwinding
I1E95_01660	COG3829	transcription factor binding
I1E95_01665	COG0625	glutathione transferase activity
I1E95_01680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I1E95_01695	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I1E95_01705	COG2197	response regulator
I1E95_01710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1E95_01715	COG0114	fumarate hydratase activity
I1E95_01735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I1E95_01750	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I1E95_01765	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I1E95_01770	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I1E95_01775	COG0473	3-isopropylmalate dehydrogenase activity
I1E95_01780	COG3954	Phosphoribulokinase
I1E95_01790	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I1E95_01795	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I1E95_01805	COG0673	inositol 2-dehydrogenase activity
I1E95_01810	COG0191	fructose-bisphosphate aldolase activity
I1E95_01820	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I1E95_01825	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I1E95_01835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1E95_01840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I1E95_01855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I1E95_01860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I1E95_01860	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I1E95_01875	COG2119	membrane
I1E95_01885	COG0557	exoribonuclease II activity
I1E95_01890	COG0163	prenyltransferase activity
I1E95_01905	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I1E95_01910	COG0312	modulator of DNA gyrase
I1E95_01920	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I1E95_01925	COG2326	polyphosphate kinase activity
I1E95_01950	COG1269	ATP hydrolysis coupled proton transport
I1E95_01970	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
I1E95_01975	COG0513	Belongs to the DEAD box helicase family
I1E95_02000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I1E95_02005	COG0281	malic enzyme
I1E95_02010	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I1E95_02100	COG0443	Heat shock 70 kDa protein
I1E95_02120	COG3328	transposase activity
I1E95_02135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1E95_02150	COG3328	transposase activity
I1E95_02195	COG3328	transposase activity
I1E95_02240	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I1E95_02245	COG1233	COG1233 Phytoene dehydrogenase and related
I1E95_02270	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I1E95_02275	COG0271	Belongs to the BolA IbaG family
I1E95_02290	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I1E95_02310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I1E95_02315	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I1E95_02325	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I1E95_02345	COG0513	Belongs to the DEAD box helicase family
I1E95_02360	COG0724	RNA recognition motif
I1E95_02365	COG1132	(ABC) transporter
I1E95_02390	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I1E95_02395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I1E95_02430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I1E95_02435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1E95_02450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I1E95_02455	COG2176	DNA-directed DNA polymerase activity
I1E95_02465	COG1283	sodium-dependent phosphate transmembrane transporter activity
I1E95_02475	COG0598	Magnesium transport protein CorA
I1E95_02525	COG1122	ATPase activity
I1E95_02535	COG1064	alcohol dehydrogenase
I1E95_02575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_02585	COG3848	Pyruvate phosphate dikinase
I1E95_02585	COG0574	Belongs to the PEP-utilizing enzyme family
I1E95_02595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I1E95_02595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1E95_02600	COG2326	polyphosphate kinase activity
I1E95_02605	COG0300	oxidoreductase activity
I1E95_02610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I1E95_02620	COG1132	(ABC) transporter
I1E95_02630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I1E95_02635	COG0505	Belongs to the CarA family
I1E95_02645	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I1E95_02650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I1E95_02660	COG0154	amidase activity
I1E95_02665	COG0587	DNA-directed DNA polymerase activity
I1E95_02675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I1E95_02680	COG0632	four-way junction helicase activity
I1E95_02690	COG0076	glutamate decarboxylase activity
I1E95_02700	COG0358	DNA primase activity
I1E95_02765	COG0069	glutamate synthase activity
I1E95_02785	COG1484	DNA-dependent DNA replication
I1E95_02800	COG1028	Short-chain dehydrogenase reductase Sdr
I1E95_02840	COG2890	protein-(glutamine-N5) methyltransferase activity
I1E95_02855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I1E95_02860	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I1E95_02875	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I1E95_02900	COG1836	PFAM Integral membrane protein DUF92
I1E95_02915	COG3639	organic phosphonate transmembrane transporter activity
I1E95_02920	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I1E95_02920	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I1E95_02930	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I1E95_02935	COG0436	Aminotransferase
I1E95_02940	COG1573	uracil-dna glycosylase
I1E95_02945	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I1E95_02950	COG0793	Belongs to the peptidase S41A family
I1E95_02960	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I1E95_02975	COG0861	Integral membrane protein TerC family
I1E95_02985	COG2119	membrane
I1E95_03000	COG0395	ABC-type sugar transport system, permease component
I1E95_03005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I1E95_03015	COG1543	Belongs to the glycosyl hydrolase 57 family
I1E95_03025	COG0589	response to stress
I1E95_03030	COG0644	oxidoreductase
I1E95_03035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I1E95_03050	COG0516	GMP reductase activity
I1E95_03055	COG3118	belongs to the thioredoxin family
I1E95_03060	COG1611	Belongs to the LOG family
I1E95_03065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I1E95_03080	COG2010	Cytochrome c
I1E95_03085	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I1E95_03100	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
I1E95_03105	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I1E95_03110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I1E95_03125	COG2166	iron-sulfur cluster assembly
I1E95_03130	COG0460	homoserine dehydrogenase
I1E95_03140	COG0747	negative chemotaxis
I1E95_03145	COG0601	transmembrane transport
I1E95_03170	COG0012	GTP binding
I1E95_03180	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I1E95_03190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_03195	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I1E95_03210	COG0194	GDP metabolic process
I1E95_03215	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I1E95_03220	COG0805	protein transport
I1E95_03230	COG0723	plastoquinol--plastocyanin reductase activity
I1E95_03235	COG0739	heme binding
I1E95_03240	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I1E95_03260	COG0248	Ppx GppA phosphatase
I1E95_03265	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I1E95_03275	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I1E95_03290	COG1028	Short-chain dehydrogenase reductase Sdr
I1E95_03300	COG0459	protein refolding
I1E95_03305	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I1E95_03325	COG0109	protoheme IX farnesyltransferase activity
I1E95_03340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I1E95_03345	COG1845	cytochrome c oxidase, subunit III
I1E95_03380	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I1E95_03395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I1E95_03400	COG1007	ATP synthesis coupled electron transport
I1E95_03405	COG1136	(ABC) transporter
I1E95_03405	COG0577	efflux transmembrane transporter activity
I1E95_03410	COG0739	heme binding
I1E95_03415	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I1E95_03415	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I1E95_03420	COG0436	Aminotransferase
I1E95_03425	COG3118	belongs to the thioredoxin family
I1E95_03430	COG1842	Phage shock protein A
I1E95_03445	COG0438	transferase activity, transferring glycosyl groups
I1E95_03450	COG0697	spore germination
I1E95_03455	COG0616	signal peptide processing
I1E95_03470	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I1E95_03475	COG0594	ribonuclease P activity
I1E95_03485	COG0706	membrane insertase activity
I1E95_03495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1E95_03500	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I1E95_03505	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I1E95_03525	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I1E95_03530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I1E95_03545	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I1E95_03555	COG0134	indole-3-glycerol-phosphate synthase activity
I1E95_03560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1E95_03565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I1E95_03580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I1E95_03585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I1E95_03590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I1E95_03595	COG0285	dihydrofolate synthase activity
I1E95_03610	COG1228	amidohydrolase
I1E95_03630	COG4948	Mandelate Racemase Muconate Lactonizing
I1E95_03635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I1E95_03640	COG1181	Belongs to the D-alanine--D-alanine ligase family
I1E95_03655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I1E95_03665	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I1E95_03670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I1E95_03675	COG4956	integral membrane protein (PIN domain superfamily)
I1E95_03680	COG0740	serine-type endopeptidase activity
I1E95_03685	COG0740	serine-type endopeptidase activity
I1E95_03700	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I1E95_03705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I1E95_03785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I1E95_03795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1E95_03800	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_03810	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I1E95_03815	COG1429	ligase activity, forming nitrogen-metal bonds
I1E95_03820	COG0435	Glutathione S-transferase
I1E95_03825	COG0778	Nitroreductase
I1E95_03830	COG1028	Short-chain dehydrogenase reductase Sdr
I1E95_03835	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I1E95_03840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I1E95_03850	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I1E95_03865	COG1649	PFAM Uncharacterised BCR, COG1649
I1E95_03870	COG1959	2 iron, 2 sulfur cluster binding
I1E95_03890	COG0842	Transport permease protein
I1E95_03895	COG0842	Transport permease protein
I1E95_03895	COG1129	ABC transporter
I1E95_03900	COG1131	(ABC) transporter
I1E95_03905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I1E95_03920	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I1E95_03935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I1E95_03940	COG1136	(ABC) transporter
I1E95_03945	COG0577	efflux transmembrane transporter activity
I1E95_03945	COG1136	(ABC) transporter
I1E95_03950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I1E95_03955	COG0531	amino acid
I1E95_03980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1E95_04010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I1E95_04035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I1E95_04050	COG0318	PFAM AMP-dependent synthetase and ligase
I1E95_04075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1E95_04180	COG0723	plastoquinol--plastocyanin reductase activity
I1E95_04220	COG3328	transposase activity
I1E95_04230	COG1872	DUF167
I1E95_04260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I1E95_04360	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I1E95_04500	COG3328	transposase activity
I1E95_04545	COG3328	transposase activity
I1E95_04625	COG3328	transposase activity
I1E95_04650	COG0582	viral genome integration into host DNA
I1E95_04660	COG3237	CsbD-like
I1E95_04670	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1E95_04690	COG0752	glycyl-tRNA synthetase alpha subunit
I1E95_04715	COG2226	methyltransferase
I1E95_04725	COG0107	imidazoleglycerol-phosphate synthase activity
I1E95_04735	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I1E95_04740	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I1E95_04745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I1E95_04745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I1E95_04750	COG3695	enzyme binding
I1E95_04755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1E95_04760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I1E95_04775	COG0714	Associated with various cellular activities
I1E95_04845	COG3328	transposase activity
I1E95_04855	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I1E95_04860	COG3657	addiction module killer protein
I1E95_04880	COG2226	methyltransferase
I1E95_04895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I1E95_04900	COG0719	Fe-S assembly protein
I1E95_04905	COG0396	ATPase activity
I1E95_04910	COG0719	Fe-S assembly protein
I1E95_04915	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
I1E95_04940	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I1E95_04975	COG0033	Phosphoglucomutase
I1E95_05000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I1E95_05025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I1E95_05030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I1E95_05035	COG0175	sulfate reduction
I1E95_05040	COG1252	NADH dehydrogenase
I1E95_05050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I1E95_05055	COG0471	metal ion transport
I1E95_05055	COG3273	potassium ion transport
I1E95_05060	COG0450	alkyl hydroperoxide reductase
I1E95_05065	COG0569	domain protein
I1E95_05070	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I1E95_05095	COG0488	(ABC) transporter
I1E95_05110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1E95_05125	COG1643	Atp-dependent helicase
I1E95_05130	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_05140	COG1570	exodeoxyribonuclease VII activity
I1E95_05195	COG0483	inositol monophosphate 1-phosphatase activity
I1E95_05215	COG1968	undecaprenyl-diphosphatase activity
I1E95_05225	COG1555	photosystem II stabilization
I1E95_05230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I1E95_05235	COG4243	Vitamin k epoxide reductase
I1E95_05240	COG0434	BtpA family
I1E95_05245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I1E95_05260	COG1032	radical SAM domain protein
I1E95_05290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I1E95_05315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I1E95_05320	COG1472	Belongs to the glycosyl hydrolase 3 family
I1E95_05325	COG0463	Glycosyl transferase, family 2
I1E95_05325	COG0457	Tetratricopeptide repeat
I1E95_05330	COG1587	Uroporphyrinogen-III synthase
I1E95_05345	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I1E95_05350	COG0316	Belongs to the HesB IscA family
I1E95_05370	COG1090	epimerase
I1E95_05380	COG0484	heat shock protein binding
I1E95_05385	COG3659	wide pore channel activity
I1E95_05390	COG3659	wide pore channel activity
I1E95_05420	COG1122	ATPase activity
I1E95_05430	COG0745	RESPONSE REGULATOR receiver
I1E95_05435	COG0470	DNA polymerase III
I1E95_05440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I1E95_05445	COG2217	Heavy metal translocating P-type atpase
I1E95_05450	COG0457	Tetratricopeptide repeat
I1E95_05455	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I1E95_05460	COG0745	RESPONSE REGULATOR receiver
I1E95_05465	COG0416	fatty acid biosynthetic process
I1E95_05470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I1E95_05475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I1E95_05490	COG1214	PFAM Peptidase M22, glycoprotease
I1E95_05500	COG0617	tRNA 3'-terminal CCA addition
I1E95_05505	COG0724	RNA recognition motif
I1E95_05515	COG1562	ergosterol biosynthetic process
I1E95_05520	COG0493	'glutamate synthase
I1E95_05520	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I1E95_05535	COG0583	DNA-binding transcription factor activity
I1E95_05545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I1E95_05550	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_05565	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I1E95_05585	COG2954	triphosphatase activity
I1E95_05590	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I1E95_05600	COG0839	Belongs to the complex I subunit 6 family
I1E95_05605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_05610	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I1E95_05615	COG0372	Belongs to the citrate synthase family
I1E95_05620	COG2062	phosphohistidine phosphatase, SixA
I1E95_05630	COG1054	Belongs to the UPF0176 family
I1E95_05635	COG1420	regulation of RNA biosynthetic process
I1E95_05645	COG0133	tryptophan synthase activity
I1E95_05655	COG0023	Translation Initiation Factor
I1E95_05660	COG0529	Catalyzes the synthesis of activated sulfate
I1E95_05665	COG0628	permease
I1E95_05675	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I1E95_05680	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I1E95_05685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I1E95_05690	COG0070	glutamate synthase
I1E95_05690	COG0069	glutamate synthase activity
I1E95_05690	COG0067	glutamate synthase
I1E95_05710	COG0049	tRNA binding
I1E95_05715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I1E95_05720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I1E95_05725	COG0051	transcription antitermination factor activity, RNA binding
I1E95_05735	COG2226	methyltransferase
I1E95_05740	COG0077	Prephenate dehydratase
I1E95_05740	COG1605	Chorismate mutase
I1E95_05750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I1E95_05755	COG1530	ribonuclease E activity
I1E95_05765	COG0436	Aminotransferase
I1E95_05770	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I1E95_05785	COG3328	transposase activity
I1E95_05795	COG3328	transposase activity
I1E95_05815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I1E95_05820	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I1E95_05835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I1E95_05845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1E95_05850	COG2046	Belongs to the sulfate adenylyltransferase family
I1E95_05850	COG0529	Catalyzes the synthesis of activated sulfate
I1E95_05865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I1E95_05870	COG3536	Protein conserved in bacteria
I1E95_05880	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
I1E95_05895	COG0540	Belongs to the ATCase OTCase family
I1E95_05900	COG2094	Belongs to the DNA glycosylase MPG family
I1E95_05915	COG1402	creatininase
I1E95_05920	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I1E95_05935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I1E95_05940	COG0640	Transcriptional regulator
I1E95_05945	COG0798	PFAM Bile acid sodium symporter
I1E95_05950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I1E95_05955	COG5002	protein histidine kinase activity
I1E95_05960	COG0745	RESPONSE REGULATOR receiver
I1E95_05965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1E95_06010	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I1E95_06045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I1E95_06070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1E95_06085	COG0717	Belongs to the dCTP deaminase family
I1E95_06095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1E95_06100	COG4372	Transposase
I1E95_06115	COG0193	aminoacyl-tRNA hydrolase activity
I1E95_06120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I1E95_06150	COG0066	3-isopropylmalate dehydratase activity
I1E95_06155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I1E95_06165	COG1546	Belongs to the CinA family
I1E95_06165	COG1058	Belongs to the CinA family
I1E95_06170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I1E95_06175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I1E95_06200	COG0728	peptidoglycan biosynthetic process
I1E95_06205	COG1489	DNA binding
I1E95_06210	COG0004	ammonium transporteR
I1E95_06215	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I1E95_06230	COG0138	bifunctional purine biosynthesis protein purh
I1E95_06245	COG2205	protein histidine kinase activity
I1E95_06250	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I1E95_06255	COG0343	queuine tRNA-ribosyltransferase activity
I1E95_06275	COG0673	inositol 2-dehydrogenase activity
I1E95_06280	COG1253	flavin adenine dinucleotide binding
I1E95_06285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I1E95_06290	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_06295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1E95_06300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I1E95_06305	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I1E95_06310	COG0463	Glycosyl transferase, family 2
I1E95_06325	COG3328	transposase activity
I1E95_06345	COG1484	DNA-dependent DNA replication
I1E95_06350	COG3328	transposase activity
I1E95_06370	COG3328	transposase activity
I1E95_06375	COG0463	Glycosyl transferase, family 2
I1E95_06385	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I1E95_06400	COG1473	amidohydrolase
I1E95_06425	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I1E95_06470	COG2826	transposase and inactivated derivatives, IS30 family
I1E95_06475	COG2801	Transposase and inactivated derivatives
I1E95_06480	COG3328	transposase activity
I1E95_06505	COG1132	(ABC) transporter
I1E95_06535	COG0617	tRNA 3'-terminal CCA addition
I1E95_06540	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I1E95_06545	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I1E95_06555	COG5398	heme oxygenase
I1E95_06565	COG0538	isocitrate dehydrogenase activity
I1E95_06570	COG0247	lactate metabolic process
I1E95_06580	COG0277	FAD linked oxidase domain protein
I1E95_06635	COG0668	transmembrane transport
I1E95_06685	COG0071	Belongs to the small heat shock protein (HSP20) family
I1E95_06695	COG3119	arylsulfatase activity
I1E95_06700	COG1116	anion transmembrane transporter activity
I1E95_06705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I1E95_06705	COG1116	anion transmembrane transporter activity
I1E95_06710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1E95_06715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I1E95_06725	COG0347	Belongs to the P(II) protein family
I1E95_06735	COG0426	domain, Protein
I1E95_06735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1E95_06740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1E95_06740	COG0426	domain, Protein
I1E95_06750	COG1902	pentaerythritol trinitrate reductase activity
I1E95_06755	COG1741	Belongs to the pirin family
I1E95_06780	COG0509	glycine decarboxylation via glycine cleavage system
I1E95_06785	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I1E95_06805	COG0359	binds to the 23S rRNA
I1E95_06810	COG0305	Participates in initiation and elongation during chromosome replication
I1E95_06810	COG0305	Participates in initiation and elongation during chromosome replication
I1E95_06810	COG1372	Participates in initiation and elongation during chromosome replication
I1E95_06810	COG1372	Participates in initiation and elongation during chromosome replication
I1E95_06835	COG0445	tRNA wobble uridine modification
I1E95_06875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I1E95_06885	COG0398	Pfam SNARE associated Golgi protein
I1E95_06910	COG1970	mechanosensitive ion channel activity
I1E95_06920	COG0525	valine-tRNA ligase activity
I1E95_06930	COG0306	phosphate transporter
I1E95_06975	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I1E95_06990	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I1E95_06990	COG3264	Mechanosensitive ion channel
I1E95_06995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I1E95_06995	COG1116	anion transmembrane transporter activity
I1E95_07000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1E95_07005	COG1116	anion transmembrane transporter activity
I1E95_07010	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I1E95_07025	COG2144	transferase activity, transferring acyl groups
I1E95_07050	COG2072	flavoprotein involved in K transport
I1E95_07060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I1E95_07075	COG0625	glutathione transferase activity
I1E95_07100	COG2217	Heavy metal translocating P-type atpase
I1E95_07115	COG2226	methyltransferase
I1E95_07130	COG0303	'Molybdopterin
I1E95_07135	COG0315	cyclic pyranopterin monophosphate synthase activity
I1E95_07145	COG1595	DNA-templated transcription, initiation
I1E95_07160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1E95_07165	COG2226	methyltransferase
I1E95_07175	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I1E95_07180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1E95_07185	COG0170	dolichyl monophosphate biosynthetic process
I1E95_07195	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I1E95_07200	COG1049	propionate catabolic process, 2-methylcitrate cycle
I1E95_07225	COG0788	formyltetrahydrofolate deformylase activity
I1E95_07240	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I1E95_07245	COG0443	Heat shock 70 kDa protein
I1E95_07250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I1E95_07260	COG0360	Binds together with S18 to 16S ribosomal RNA
I1E95_07270	COG0137	argininosuccinate synthase activity
I1E95_07285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I1E95_07300	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I1E95_07315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I1E95_07320	COG0497	DNA recombination
I1E95_07325	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I1E95_07335	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I1E95_07340	COG0592	DNA-directed DNA polymerase activity
I1E95_07355	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I1E95_07360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I1E95_07370	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I1E95_07385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I1E95_07390	COG0552	protein localization to endoplasmic reticulum
I1E95_07395	COG2208	phosphoserine phosphatase activity
I1E95_07400	COG0165	Argininosuccinate lyase
I1E95_07405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I1E95_07410	COG2081	HI0933 family
I1E95_07435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I1E95_07440	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I1E95_07445	COG0484	heat shock protein binding
I1E95_07460	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I1E95_07465	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I1E95_07470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I1E95_07475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I1E95_07480	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I1E95_07485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I1E95_07490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I1E95_07495	COG0511	ligase activity, forming carbon-carbon bonds
I1E95_07500	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I1E95_07585	COG0402	S-adenosylhomocysteine deaminase activity
I1E95_07590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I1E95_07590	COG0784	Response regulator, receiver
I1E95_07600	COG1028	Short-chain dehydrogenase reductase Sdr
I1E95_07685	COG3328	transposase activity
I1E95_07865	COG1061	Type III restriction enzyme res subunit
I1E95_07940	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I1E95_07945	COG0519	Catalyzes the synthesis of GMP from XMP
I1E95_07945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I1E95_07960	COG0768	penicillin binding
I1E95_07965	COG0438	transferase activity, transferring glycosyl groups
I1E95_07965	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I1E95_07980	COG2022	thiamine diphosphate biosynthetic process
I1E95_07995	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I1E95_08000	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I1E95_08005	COG2385	sporulation resulting in formation of a cellular spore
I1E95_08010	COG1215	transferase activity, transferring glycosyl groups
I1E95_08015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I1E95_08025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I1E95_08030	COG0740	serine-type endopeptidase activity
I1E95_08035	COG0544	peptidyl-prolyl cis-trans isomerase activity
I1E95_08040	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I1E95_08045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I1E95_08050	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I1E95_08060	COG0037	tRNA processing
I1E95_08075	COG0556	nucleotide-excision repair
I1E95_08080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I1E95_08105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I1E95_08115	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I1E95_08120	COG0438	transferase activity, transferring glycosyl groups
I1E95_08175	COG3328	transposase activity
I1E95_08210	COG3328	transposase activity
I1E95_08225	COG0653	protein targeting
I1E95_08235	COG1725	Transcriptional regulator
I1E95_08245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I1E95_08250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I1E95_08255	COG0187	DNA topoisomerase II activity
I1E95_08255	COG1372	Participates in initiation and elongation during chromosome replication
I1E95_08270	COG0386	Belongs to the glutathione peroxidase family
I1E95_08275	COG2239	Acts as a magnesium transporter
I1E95_08280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1E95_08300	COG0802	atpase or kinase
I1E95_08305	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I1E95_08310	COG0586	Pfam SNARE associated Golgi protein
I1E95_08315	COG0629	single-stranded DNA binding
I1E95_08340	COG0745	RESPONSE REGULATOR receiver
I1E95_08345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I1E95_08370	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I1E95_08375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I1E95_08385	COG0515	serine threonine protein kinase
I1E95_08385	COG3266	domain, Protein
I1E95_08390	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I1E95_08395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I1E95_08425	COG0411	ABC transporter
I1E95_08445	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I1E95_08450	COG0830	nickel cation binding
I1E95_08455	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I1E95_08460	COG0829	nickel cation binding
I1E95_08465	COG2211	Major facilitator Superfamily
I1E95_08475	COG0832	Belongs to the urease beta subunit family
I1E95_08485	COG2308	Evidence 4 Homologs of previously reported genes of
I1E95_08500	COG0058	SHG alpha-glucan phosphorylase activity
I1E95_08510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I1E95_08515	COG0709	Synthesizes selenophosphate from selenide and ATP
I1E95_08520	COG0662	Cupin 2, conserved barrel domain protein
I1E95_08520	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I1E95_08525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I1E95_08535	COG0571	ribonuclease III activity
I1E95_08560	COG0058	SHG alpha-glucan phosphorylase activity
I1E95_08565	COG0475	glutathione-regulated potassium exporter activity
I1E95_08585	COG0010	Belongs to the arginase family
I1E95_08590	COG0375	protein maturation
I1E95_08615	COG1116	anion transmembrane transporter activity
I1E95_08640	COG1653	transport
I1E95_08645	COG1175	transmembrane transport
I1E95_08650	COG0395	ABC-type sugar transport system, permease component
I1E95_08655	COG3842	ATPase activity
I1E95_08690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I1E95_08720	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I1E95_08730	COG1704	LemA family
I1E95_08785	COG3956	TIGRFAM MazG family protein
I1E95_08805	COG0010	Belongs to the arginase family
I1E95_08825	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I1E95_08830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1E95_08835	COG0783	Belongs to the Dps family
I1E95_08840	COG0504	CTP synthase activity
I1E95_08855	COG0602	queuosine metabolic process
I1E95_08860	COG0124	histidyl-tRNA synthetase
I1E95_08865	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I1E95_08900	COG4447	cellulose binding
I1E95_08905	COG1773	rubredoxin
I1E95_08910	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_08915	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_08925	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I1E95_08930	COG3842	ATPase activity
I1E95_08940	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
I1E95_08940	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
I1E95_08970	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I1E95_08985	COG3328	transposase activity
I1E95_09000	COG0644	oxidoreductase
I1E95_09005	COG2890	protein-(glutamine-N5) methyltransferase activity
I1E95_09020	COG0598	Magnesium transport protein CorA
I1E95_09035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1E95_09045	COG1032	radical SAM domain protein
I1E95_09080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1E95_09110	COG2345	Transcriptional regulator
I1E95_09115	COG0154	amidase activity
I1E95_09155	COG0556	nucleotide-excision repair
I1E95_09165	COG3328	transposase activity
I1E95_09205	COG2361	Protein of unknown function DUF86
I1E95_09270	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_09275	COG2124	cytochrome p450
I1E95_09285	COG4413	Urea transporter
I1E95_09335	COG0071	Belongs to the small heat shock protein (HSP20) family
I1E95_09340	COG1231	oxidoreductase activity
I1E95_09350	COG2226	methyltransferase
I1E95_09365	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I1E95_09370	COG0494	nUDIX hydrolase
I1E95_09375	COG0415	Belongs to the DNA photolyase family
I1E95_09405	COG0415	Belongs to the DNA photolyase family
I1E95_09410	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I1E95_09420	COG0131	Imidazoleglycerol-phosphate dehydratase
I1E95_09425	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
I1E95_09455	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I1E95_09455	COG3264	Mechanosensitive ion channel
I1E95_09485	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I1E95_09490	COG3119	arylsulfatase activity
I1E95_09500	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I1E95_09505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I1E95_09515	COG0354	folic acid binding
I1E95_09520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I1E95_09575	COG3328	transposase activity
I1E95_09605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I1E95_09620	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I1E95_09625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I1E95_09635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I1E95_09640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1E95_09645	COG1116	anion transmembrane transporter activity
I1E95_09645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I1E95_09650	COG1116	anion transmembrane transporter activity
I1E95_09655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1E95_09660	COG0243	molybdopterin cofactor binding
I1E95_09675	COG0746	molybdenum cofactor guanylyltransferase activity
I1E95_09680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I1E95_09725	COG2814	Major facilitator Superfamily
I1E95_09740	COG0438	transferase activity, transferring glycosyl groups
I1E95_09745	COG3100	YcgL domain-containing protein
I1E95_09745	COG0561	phosphatase activity
I1E95_09760	COG0521	Mo-molybdopterin cofactor biosynthetic process
I1E95_09770	COG1803	Methylglyoxal synthase
I1E95_09770	COG1597	lipid kinase activity
I1E95_09775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I1E95_09785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I1E95_09790	COG2066	Belongs to the glutaminase family
I1E95_09790	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I1E95_09805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1E95_09825	COG1166	arginine decarboxylase activity
I1E95_09895	COG0105	UTP biosynthetic process
I1E95_09905	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I1E95_09920	COG2022	thiamine diphosphate biosynthetic process
I1E95_09920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I1E95_09940	COG0237	dephospho-CoA kinase activity
I1E95_09945	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I1E95_09960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I1E95_09965	COG0148	phosphopyruvate hydratase activity
I1E95_09970	COG0346	lactoylglutathione lyase activity
I1E95_09975	COG0542	response to heat
I1E95_09980	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I1E95_09985	COG0250	Participates in transcription elongation, termination and antitermination
I1E95_09990	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I1E95_09995	COG0081	regulation of translation
I1E95_10000	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I1E95_10005	COG0222	ribosome binding
I1E95_10020	COG0167	dihydroorotate dehydrogenase activity
I1E95_10055	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I1E95_10065	COG2084	Dehydrogenase
I1E95_10080	COG0589	response to stress
I1E95_10085	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I1E95_10090	COG0564	pseudouridine synthase activity
I1E95_10095	COG0038	chloride channel
I1E95_10100	COG4172	Belongs to the ABC transporter superfamily
I1E95_10105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I1E95_10140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I1E95_10145	COG0157	Belongs to the NadC ModD family
I1E95_10165	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I1E95_10190	COG0641	radical SAM
I1E95_10195	COG0018	arginyl-trna synthetase
I1E95_10200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I1E95_10215	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I1E95_10220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I1E95_10235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I1E95_10240	COG0189	ligase activity
I1E95_10250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1E95_10260	COG1575	Belongs to the MenA family. Type 1 subfamily
I1E95_10290	COG0824	Thioesterase
I1E95_10295	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I1E95_10310	COG0275	rRNA processing
I1E95_10320	COG1104	cysteine desulfurase activity
I1E95_10330	COG0745	RESPONSE REGULATOR receiver
I1E95_10335	COG0564	pseudouridine synthase activity
I1E95_10345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I1E95_10365	COG2885	chlorophyll binding
I1E95_10370	COG2885	chlorophyll binding
I1E95_10395	COG0463	Glycosyl transferase, family 2
I1E95_10400	COG0791	NLP P60 protein
I1E95_10415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I1E95_10425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I1E95_10430	COG0254	rRNA binding
I1E95_10435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I1E95_10445	COG0101	tRNA pseudouridine synthase activity
I1E95_10450	COG0203	ribosomal protein L17
I1E95_10455	COG0202	RNA polymerase activity
I1E95_10465	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I1E95_10470	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I1E95_10475	COG0563	adenylate kinase activity
I1E95_10480	COG0201	protein transport
I1E95_10485	COG0200	Binds to the 23S rRNA
I1E95_10490	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I1E95_10495	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I1E95_10500	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I1E95_10505	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I1E95_10510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I1E95_10515	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I1E95_10520	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I1E95_10525	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I1E95_10530	COG0255	Belongs to the universal ribosomal protein uL29 family
I1E95_10535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I1E95_10540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I1E95_10545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I1E95_10550	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I1E95_10555	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I1E95_10560	COG0089	rRNA binding
I1E95_10565	COG0088	Forms part of the polypeptide exit tunnel
I1E95_10570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I1E95_10585	COG3854	ATPases associated with a variety of cellular activities
I1E95_10630	COG3001	Fructosamine kinase
I1E95_10650	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I1E95_10655	COG1606	tRNA processing
I1E95_10660	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I1E95_10665	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I1E95_10675	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I1E95_10680	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I1E95_10685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I1E95_10700	COG0772	Belongs to the SEDS family
I1E95_10705	COG0489	protein tyrosine kinase activity
I1E95_10710	COG0408	coproporphyrinogen oxidase activity
I1E95_10765	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I1E95_10770	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I1E95_10770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I1E95_10775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I1E95_10820	COG5398	heme oxygenase
I1E95_10890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_10905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I1E95_10920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I1E95_10960	COG1070	Carbohydrate kinase
I1E95_10975	COG0539	negative regulation of cytoplasmic translation
I1E95_11020	COG2890	protein-(glutamine-N5) methyltransferase activity
I1E95_11025	COG0009	L-threonylcarbamoyladenylate synthase
I1E95_11065	COG0651	ATP synthesis coupled electron transport
I1E95_11070	COG1006	Multisubunit Na H antiporter MnhC subunit
I1E95_11080	COG3328	transposase activity
I1E95_11095	COG4566	intracellular signal transduction
I1E95_11100	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I1E95_11105	COG2894	cell division
I1E95_11125	COG0850	regulation of cytokinetic process
I1E95_11130	COG1078	dGTPase activity
I1E95_11135	COG0793	Belongs to the peptidase S41A family
I1E95_11140	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I1E95_11145	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I1E95_11180	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I1E95_11185	COG0235	Class ii aldolase
I1E95_11190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I1E95_11205	COG0514	ATP-dependent DNA helicase (RecQ)
I1E95_11210	COG1388	LysM domain
I1E95_11210	COG1705	Flagellar rod assembly protein muramidase FlgJ
I1E95_11215	COG1012	belongs to the aldehyde dehydrogenase family
I1E95_11230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I1E95_11255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I1E95_11265	COG1160	GTP binding
I1E95_11270	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I1E95_11280	COG3328	transposase activity
I1E95_11285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I1E95_11290	COG1799	cell septum assembly
I1E95_11295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I1E95_11300	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I1E95_11315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I1E95_11320	COG2211	Major facilitator Superfamily
I1E95_11330	COG1523	belongs to the glycosyl hydrolase 13 family
I1E95_11340	COG0776	regulation of translation
I1E95_11370	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I1E95_11370	COG1013	pyruvate-flavodoxin oxidoreductase activity
I1E95_11370	COG0674	pyruvate-flavodoxin oxidoreductase activity
I1E95_11370	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I1E95_11375	COG0298	carbon dioxide binding
I1E95_11380	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I1E95_11385	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I1E95_11390	COG0375	protein maturation
I1E95_11400	COG3259	Nickel-dependent hydrogenase
I1E95_11410	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_11455	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I1E95_11460	COG1218	3'(2'),5'-bisphosphate nucleotidase
I1E95_11470	COG1185	polyribonucleotide nucleotidyltransferase activity
I1E95_11480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I1E95_11485	COG0750	zinc metalloprotease
I1E95_11495	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I1E95_11500	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I1E95_11505	COG0481	GTPase activity
I1E95_11550	COG4795	General secretion pathway protein
I1E95_11575	COG3328	transposase activity
I1E95_11590	COG3328	transposase activity
I1E95_11595	COG4968	Prepilin-type N-terminal cleavage methylation domain
I1E95_11610	COG0745	RESPONSE REGULATOR receiver
I1E95_11615	COG3328	transposase activity
I1E95_11670	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I1E95_11675	COG0598	Magnesium transport protein CorA
I1E95_11680	COG3347	Dehydrogenase
I1E95_11680	COG1028	Short-chain dehydrogenase reductase Sdr
I1E95_11695	COG0242	peptide deformylase activity
I1E95_11710	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I1E95_11715	COG0606	chelatase, subunit chli
I1E95_11720	COG0537	adenosine 5'-monophosphoramidase activity
I1E95_11725	COG4178	(ABC) transporter
I1E95_11745	COG0515	serine threonine protein kinase
I1E95_11760	COG0439	Biotin carboxylase
I1E95_11775	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I1E95_11785	COG1196	nuclear chromosome segregation
I1E95_11805	COG0116	Belongs to the methyltransferase superfamily
I1E95_11820	COG3328	transposase activity
I1E95_11915	COG4243	Vitamin k epoxide reductase
I1E95_11920	COG0484	heat shock protein binding
I1E95_11925	COG0113	porphobilinogen synthase activity
I1E95_11935	COG1193	negative regulation of DNA recombination
I1E95_11940	COG3842	ATPase activity
I1E95_11945	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I1E95_11955	COG0488	(ABC) transporter
I1E95_11965	COG0435	Glutathione S-transferase
I1E95_11970	COG2988	succinylglutamate desuccinylase activity
I1E95_12015	COG3266	domain, Protein
I1E95_12015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I1E95_12025	COG0195	Participates in both transcription termination and antitermination
I1E95_12030	COG0779	Required for maturation of 30S ribosomal subunits
I1E95_12040	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I1E95_12045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1E95_12050	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I1E95_12055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I1E95_12065	COG0084	hydrolase, TatD family'
I1E95_12075	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I1E95_12080	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I1E95_12085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_12090	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I1E95_12095	COG2223	nitrite transmembrane transporter activity
I1E95_12125	COG0357	Ribosomal RNA small subunit methyltransferase G
I1E95_12130	COG0484	heat shock protein binding
I1E95_12140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I1E95_12150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I1E95_12155	COG2226	methyltransferase
I1E95_12165	COG0156	8-amino-7-oxononanoate synthase activity
I1E95_12170	COG4581	dead DEAH box helicase
I1E95_12175	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I1E95_12185	COG0347	Belongs to the P(II) protein family
I1E95_12195	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I1E95_12210	COG0772	Belongs to the SEDS family
I1E95_12230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I1E95_12235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I1E95_12255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I1E95_12260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I1E95_12270	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I1E95_12275	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I1E95_12285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I1E95_12295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I1E95_12300	COG0686	Belongs to the AlaDH PNT family
I1E95_12305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I1E95_12305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I1E95_12310	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I1E95_12315	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I1E95_12320	COG1253	flavin adenine dinucleotide binding
I1E95_12325	COG0006	proline dipeptidase activity
I1E95_12370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1E95_12385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I1E95_12390	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I1E95_12395	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I1E95_12400	COG0459	protein refolding
I1E95_12415	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I1E95_12420	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I1E95_12435	COG0443	Heat shock 70 kDa protein
I1E95_12470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I1E95_12490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I1E95_12495	COG2264	protein methyltransferase activity
I1E95_12510	COG2010	Cytochrome c
I1E95_12515	COG1234	tRNA 3'-trailer cleavage
I1E95_12520	COG2385	sporulation resulting in formation of a cellular spore
I1E95_12525	COG0363	glucosamine-6-phosphate deaminase activity
I1E95_12530	COG0217	transcriptional regulatory protein
I1E95_12535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I1E95_12540	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I1E95_12545	COG0500	methyltransferase
I1E95_12550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I1E95_12555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I1E95_12565	COG4251	negative regulation of phosphorylation
I1E95_12570	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
I1E95_12575	COG5002	protein histidine kinase activity
I1E95_12580	COG0151	Belongs to the GarS family
I1E95_12600	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I1E95_12605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I1E95_12610	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I1E95_12615	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I1E95_12620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I1E95_12635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I1E95_12660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I1E95_12665	COG0284	orotidine-5'-phosphate decarboxylase activity
I1E95_12670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I1E95_12680	COG0438	transferase activity, transferring glycosyl groups
I1E95_12690	COG1381	Involved in DNA repair and RecF pathway recombination
I1E95_12695	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I1E95_12700	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I1E95_12705	COG0321	lipoyl(octanoyl) transferase activity
I1E95_12710	COG1022	Amp-dependent synthetase and ligase
I1E95_12720	COG0508	dehydrogenase complex catalyzes the overall conversion of
I1E95_12725	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I1E95_12730	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I1E95_12745	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I1E95_12755	COG0724	RNA recognition motif
I1E95_12765	COG1799	cell septum assembly
I1E95_12795	COG0366	Alpha amylase catalytic
I1E95_12810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I1E95_12815	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I1E95_12820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1E95_12865	COG0628	permease
I1E95_12895	COG0668	transmembrane transport
I1E95_12900	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I1E95_12900	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I1E95_12930	COG0745	RESPONSE REGULATOR receiver
I1E95_12935	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I1E95_12940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I1E95_12945	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I1E95_12955	COG0196	riboflavin kinase activity
I1E95_12960	COG0352	thiamine-phosphate diphosphorylase activity
I1E95_12975	COG1691	(AIR) carboxylase
I1E95_12985	COG0336	Belongs to the RNA methyltransferase TrmD family
I1E95_12995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I1E95_13005	COG0670	Belongs to the BI1 family
I1E95_13010	COG1702	phosphate starvation-inducible protein PhoH
I1E95_13020	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I1E95_13030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I1E95_13035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1E95_13040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I1E95_13040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I1E95_13045	COG0482	sulfurtransferase activity
I1E95_13055	COG1492	cobalamin metabolic process
I1E95_13065	COG0424	maF-like protein
I1E95_13090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I1E95_13095	COG0440	acetolactate synthase activity
I1E95_13100	COG2267	carboxylic ester hydrolase activity
I1E95_13115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1E95_13130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I1E95_13135	COG0492	ferredoxin-NADP+ reductase activity
I1E95_13155	COG0702	epimerase
I1E95_13170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I1E95_13180	COG0215	cysteine-tRNA ligase activity
I1E95_13190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I1E95_13190	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I1E95_13205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I1E95_13225	COG0335	large ribosomal subunit rRNA binding
I1E95_13235	COG0024	Methionine aminopeptidase
I1E95_13240	COG0300	oxidoreductase activity
I1E95_13240	COG3000	fatty acid hydroxylase
I1E95_13250	COG0857	belongs to the CobB CobQ family
I1E95_13265	COG0330	HflC and HflK could
I1E95_13275	COG1666	GTP binding
I1E95_13290	COG0405	Gamma-glutamyltransferase
I1E95_13335	COG0129	dihydroxy-acid dehydratase activity
I1E95_13350	COG0363	glucosamine-6-phosphate deaminase activity
I1E95_13355	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I1E95_13360	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I1E95_13365	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I1E95_13370	COG1494	fructose-1,6-bisphosphatase
I1E95_13375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I1E95_13380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I1E95_13405	COG1217	gtp-binding protein TYPA
I1E95_13415	COG0644	oxidoreductase
I1E95_13420	COG0751	glycine-tRNA ligase activity
I1E95_13425	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I1E95_13435	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I1E95_13440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I1E95_13450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I1E95_13455	COG0052	Belongs to the universal ribosomal protein uS2 family
I1E95_13460	COG1216	Glycosyl transferase, family 2
I1E95_13490	COG0612	Peptidase, M16
I1E95_13510	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I1E95_13515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1E95_13535	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I1E95_13545	COG0174	glutamine synthetase
I1E95_13550	COG2226	methyltransferase
I1E95_13575	COG0515	serine threonine protein kinase
I1E95_13580	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I1E95_13590	COG0628	permease
I1E95_13605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I1E95_13610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I1E95_13615	COG0022	dehydrogenase e1 component
I1E95_13625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I1E95_13630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I1E95_13655	COG4555	ABC transporter
I1E95_13705	COG3128	pkhd-type hydroxylase
I1E95_13720	COG0514	ATP-dependent DNA helicase (RecQ)
I1E95_13730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I1E95_13750	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I1E95_13765	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I1E95_13780	COG0740	serine-type endopeptidase activity
I1E95_13790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1E95_13800	COG0577	efflux transmembrane transporter activity
I1E95_13800	COG1136	(ABC) transporter
I1E95_13805	COG0469	pyruvate kinase activity
I1E95_13830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I1E95_13835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I1E95_13865	COG0668	transmembrane transport
I1E95_13870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I1E95_13875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I1E95_13900	COG0483	inositol monophosphate 1-phosphatase activity
I1E95_13905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I1E95_13915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I1E95_13920	COG0581	inorganic phosphate transmembrane transporter activity
I1E95_13925	COG0573	inorganic phosphate transmembrane transporter activity
I1E95_13930	COG0443	Heat shock 70 kDa protein
I1E95_13935	COG0484	heat shock protein binding
I1E95_13945	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I1E95_13950	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I1E95_13955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I1E95_13960	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I1E95_13960	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I1E95_13965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I1E95_13970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I1E95_13995	COG0166	Belongs to the GPI family
I1E95_14000	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I1E95_14005	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I1E95_14010	COG0495	leucyl-tRNA aminoacylation
I1E95_14020	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I1E95_14040	COG2027	D-alanyl-D-alanine carboxypeptidase
I1E95_14050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I1E95_14055	COG0426	domain, Protein
I1E95_14055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1E95_14060	COG0322	excinuclease ABC activity
I1E95_14065	COG1981	membrane
I1E95_14070	COG0613	PHP domain protein
I1E95_14085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I1E95_14090	COG0646	methionine synthase
I1E95_14090	COG1410	methionine synthase
I1E95_14115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I1E95_14125	COG2385	sporulation resulting in formation of a cellular spore
I1E95_14160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I1E95_14165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I1E95_14165	COG0072	phenylalanine-tRNA ligase activity
I1E95_14170	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I1E95_14175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I1E95_14180	COG0557	exoribonuclease II activity
I1E95_14190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I1E95_14225	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I1E95_14245	COG0450	alkyl hydroperoxide reductase
I1E95_14250	COG0047	phosphoribosylformylglycinamidine synthase activity
I1E95_14255	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I1E95_14275	COG1357	PFAM Pentapeptide repeats (8 copies)
I1E95_14280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I1E95_14285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I1E95_14295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I1E95_14300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I1E95_14310	COG0297	glycogen (starch) synthase activity
I1E95_14315	COG1376	ErfK ybiS ycfS ynhG family protein
I1E95_14355	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I1E95_14360	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I1E95_14365	COG0681	Belongs to the peptidase S26 family
I1E95_14380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I1E95_14385	COG1121	(ABC) transporter
I1E95_14390	COG0803	Belongs to the bacterial solute-binding protein 9 family
I1E95_14415	COG0180	Tryptophanyl-tRNA synthetase
I1E95_14435	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I1E95_14440	COG0837	glucose binding
I1E95_14445	COG0083	homoserine kinase activity
I1E95_14450	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_14455	COG0339	signal peptide processing
I1E95_14470	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I1E95_14475	COG1940	carbohydrate kinase activity
I1E95_14510	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I1E95_14515	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I1E95_14525	COG3794	PFAM blue (type 1) copper domain protein
I1E95_14530	COG2010	Cytochrome c
I1E95_14555	COG0542	response to heat
I1E95_14570	COG0438	transferase activity, transferring glycosyl groups
I1E95_14600	COG0463	Glycosyl transferase, family 2
I1E95_14605	COG3328	transposase activity
I1E95_14635	COG2226	methyltransferase
I1E95_14655	COG0463	Glycosyl transferase, family 2
I1E95_14680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I1E95_14695	COG0546	phosphoglycolate phosphatase activity
I1E95_14700	COG3962	Belongs to the TPP enzyme family
I1E95_14725	COG3328	transposase activity
I1E95_14755	COG2801	Transposase and inactivated derivatives
I1E95_15015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1E95_15020	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I1E95_15035	COG0471	metal ion transport
I1E95_15035	COG3273	potassium ion transport
I1E95_15070	COG3328	transposase activity
I1E95_15075	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I1E95_15090	COG1088	dTDP-glucose 4,6-dehydratase activity
I1E95_15125	COG0708	Exodeoxyribonuclease III
I1E95_15145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1E95_15150	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
I1E95_15160	COG0735	belongs to the Fur family
I1E95_15180	COG1840	ABC-type Fe3 transport system, periplasmic component
I1E95_15190	COG0432	Pfam Uncharacterised protein family UPF0047
I1E95_15215	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I1E95_15220	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I1E95_15235	COG0181	hydroxymethylbilane synthase activity
I1E95_15250	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I1E95_15255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1E95_15260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I1E95_15270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I1E95_15295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I1E95_15310	COG0442	prolyl-tRNA aminoacylation
I1E95_15320	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I1E95_15335	COG1393	Belongs to the ArsC family
I1E95_15355	COG0588	phosphoglycerate mutase activity
I1E95_15370	COG0768	penicillin binding
I1E95_15375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I1E95_15385	COG0644	oxidoreductase
I1E95_15390	COG0233	cytoplasmic translational termination
I1E95_15395	COG0528	UMP kinase activity
I1E95_15410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_15420	COG0028	Belongs to the TPP enzyme family
I1E95_15445	COG0574	Belongs to the PEP-utilizing enzyme family
I1E95_15445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I1E95_15450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1E95_15455	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I1E95_15465	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_15475	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
I1E95_15485	COG0347	Belongs to the P(II) protein family
I1E95_15495	COG1126	abc transporter atp-binding protein
I1E95_15500	COG0765	amino acid transport
I1E95_15505	COG4597	amino acid ABC transporter
I1E95_15510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1E95_15515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I1E95_15520	COG0418	dihydroorotase activity
I1E95_15530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I1E95_15530	COG0284	orotidine-5'-phosphate decarboxylase activity
I1E95_15540	COG1053	succinate dehydrogenase
I1E95_15550	COG2199	diguanylate cyclase activity
I1E95_15560	COG2154	pterin-4-alpha-carbinolamine dehydratase
I1E95_15575	COG1752	Esterase of the alpha-beta hydrolase superfamily
I1E95_15600	COG3328	transposase activity
I1E95_15630	COG3328	transposase activity
I1E95_15640	COG0412	Dienelactone hydrolase
I1E95_15645	COG3328	transposase activity
I1E95_15650	COG0412	Dienelactone hydrolase
I1E95_15670	COG3328	transposase activity
I1E95_15700	COG3328	transposase activity
I1E95_15730	COG3328	transposase activity
I1E95_15795	COG3328	transposase activity
I1E95_15800	COG3328	transposase activity
I1E95_15805	COG3328	transposase activity
I1E95_15820	COG3328	transposase activity
I1E95_15825	COG3328	transposase activity
I1E95_15955	COG1111	helicase
I1E95_15955	COG1205	dead DEAH box helicase
I1E95_16000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I1E95_16030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I1E95_16080	COG0535	radical SAM domain protein
I1E95_16095	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I1E95_16140	COG1061	Type III restriction enzyme res subunit
I1E95_16335	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I1E95_16350	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I1E95_16425	COG0596	Alpha beta hydrolase
I1E95_16430	COG3263	regulation of cellular component size
I1E95_16450	COG3328	transposase activity
I1E95_16455	COG3328	transposase activity
I1E95_16470	COG2963	transposase activity
I1E95_16475	COG2801	Transposase and inactivated derivatives
I1E95_16520	COG0804	urea catabolic process
I1E95_16560	COG3328	transposase activity
I1E95_16580	COG2135	peptidase activity
I1E95_16585	COG0419	ATPase involved in DNA repair
I1E95_16590	COG0420	3'-5' exonuclease activity
I1E95_16605	COG0251	oxidation-reduction process
I1E95_16610	COG3842	ATPase activity
I1E95_16615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I1E95_16620	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I1E95_16625	COG1132	(ABC) transporter
I1E95_16635	COG0456	acetyltransferase
I1E95_16650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain