locus-tag	class	description
CYB_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CYB_0003	COG2226	methyltransferase
CYB_0004	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYB_0005	COG0300	oxidoreductase activity
CYB_0008	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CYB_0009	COG0488	(ABC) transporter
CYB_0021	COG2885	chlorophyll binding
CYB_0022	COG2885	chlorophyll binding
CYB_0023	COG0804	urea catabolic process
CYB_0024	COG3842	ATPase activity
CYB_0027	COG4134	Bacterial extracellular solute-binding protein
CYB_0028	COG5002	protein histidine kinase activity
CYB_0035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYB_0036	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYB_0037	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYB_0037	COG1116	anion transmembrane transporter activity
CYB_0038	COG1116	anion transmembrane transporter activity
CYB_0040	COG0243	molybdopterin cofactor binding
CYB_0043	COG0151	Belongs to the GarS family
CYB_0045	COG1078	dGTPase activity
CYB_0047	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CYB_0048	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYB_0049	COG0778	Nitroreductase
CYB_0050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYB_0051	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CYB_0053	COG3293	Transposase
CYB_0055	COG2052	Domain of unknown function (DUF370)
CYB_0056	COG0194	GDP metabolic process
CYB_0057	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CYB_0058	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CYB_0059	COG0123	including yeast histone deacetylase and acetoin utilization protein
CYB_0062	COG0799	negative regulation of ribosome biogenesis
CYB_0064	COG0481	GTPase activity
CYB_0068	COG1160	GTP binding
CYB_0071	COG0436	Aminotransferase
CYB_0079	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CYB_0082	COG0544	peptidyl-prolyl cis-trans isomerase activity
CYB_0084	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CYB_0088	COG1570	exodeoxyribonuclease VII activity
CYB_0089	COG1722	exodeoxyribonuclease VII activity
CYB_0090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CYB_0095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CYB_0096	COG0741	lytic transglycosylase activity
CYB_0096	COG0739	heme binding
CYB_0096	COG1196	nuclear chromosome segregation
CYB_0097	COG2062	phosphohistidine phosphatase, SixA
CYB_0100	COG0484	heat shock protein binding
CYB_0107	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CYB_0113	COG0450	alkyl hydroperoxide reductase
CYB_0115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYB_0117	COG0629	single-stranded DNA binding
CYB_0118	COG2099	Precorrin-6x reductase
CYB_0121	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CYB_0124	COG0748	coenzyme F420 binding
CYB_0125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CYB_0126	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CYB_0126	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CYB_0131	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CYB_0132	COG1178	ABC-type Fe3 transport system permease component
CYB_0136	COG1555	photosystem II stabilization
CYB_0141	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYB_0142	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CYB_0143	COG2166	iron-sulfur cluster assembly
CYB_0144	COG3443	Belongs to the bacterial solute-binding protein 9 family
CYB_0144	COG0803	Belongs to the bacterial solute-binding protein 9 family
CYB_0145	COG1121	(ABC) transporter
CYB_0147	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYB_0148	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CYB_0151	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYB_0154	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CYB_0157	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CYB_0157	COG0140	phosphoribosyl-ATP diphosphatase activity
CYB_0159	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CYB_0161	COG3639	organic phosphonate transmembrane transporter activity
CYB_0165	COG3627	carbon phosphorus lyase activity
CYB_0166	COG4107	phosphonate C-P lyase system protein PhnK
CYB_0167	COG4778	phosphonate C-P lyase system protein PhnL
CYB_0168	COG3454	Phosphonate metabolism
CYB_0169	COG0726	polysaccharide deacetylase
CYB_0169	COG1649	PFAM Uncharacterised BCR, COG1649
CYB_0174	COG0745	RESPONSE REGULATOR receiver
CYB_0177	COG1366	Belongs to the anti-sigma-factor antagonist family
CYB_0180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CYB_0181	COG4178	(ABC) transporter
CYB_0182	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CYB_0184	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CYB_0188	COG0302	gtp cyclohydrolase
CYB_0189	COG0300	oxidoreductase activity
CYB_0190	COG3842	ATPase activity
CYB_0192	COG3118	belongs to the thioredoxin family
CYB_0194	COG0135	phosphoribosylanthranilate isomerase activity
CYB_0196	COG1187	pseudouridine synthase activity
CYB_0197	COG3293	Transposase
CYB_0200	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CYB_0202	COG0415	Belongs to the DNA photolyase family
CYB_0204	COG3293	Transposase
CYB_0206	COG0303	'Molybdopterin
CYB_0208	COG1007	ATP synthesis coupled electron transport
CYB_0215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CYB_0217	COG0527	aspartate kinase activity
CYB_0223	COG0163	prenyltransferase activity
CYB_0225	COG2082	Precorrin-8x methylmutase
CYB_0229	COG1489	DNA binding
CYB_0230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CYB_0231	COG0708	Exodeoxyribonuclease III
CYB_0234	COG1176	ABC-type spermidine putrescine transport system, permease component I
CYB_0235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYB_0236	COG4208	sulfate ABC transporter
CYB_0237	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CYB_0238	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CYB_0239	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CYB_0241	COG1454	alcohol dehydrogenase
CYB_0241	COG1012	belongs to the aldehyde dehydrogenase family
CYB_0243	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CYB_0245	COG1882	Formate acetyltransferase
CYB_0246	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CYB_0247	COG0675	Transposase, IS605 OrfB family
CYB_0249	COG0745	RESPONSE REGULATOR receiver
CYB_0250	COG1834	amidinotransferase
CYB_0260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYB_0261	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CYB_0262	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CYB_0263	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CYB_0268	COG1116	anion transmembrane transporter activity
CYB_0270	COG0105	UTP biosynthetic process
CYB_0274	COG0737	Belongs to the 5'-nucleotidase family
CYB_0276	COG0515	serine threonine protein kinase
CYB_0278	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CYB_0283	COG0784	Response regulator, receiver
CYB_0284	COG0047	phosphoribosylformylglycinamidine synthase activity
CYB_0285	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CYB_0287	COG2045	Belongs to the ComB family
CYB_0289	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CYB_0292	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CYB_0293	COG0772	Belongs to the SEDS family
CYB_0298	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYB_0299	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CYB_0300	COG0575	Belongs to the CDS family
CYB_0301	COG0525	valine-tRNA ligase activity
CYB_0302	COG0724	RNA recognition motif
CYB_0308	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CYB_0310	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CYB_0312	COG0552	protein localization to endoplasmic reticulum
CYB_0315	COG4783	chaperone-mediated protein folding
CYB_0316	COG0850	regulation of cytokinetic process
CYB_0317	COG2894	cell division
CYB_0318	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CYB_0321	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CYB_0322	COG0187	DNA topoisomerase II activity
CYB_0322	COG1372	Participates in initiation and elongation during chromosome replication
CYB_0323	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CYB_0324	COG0330	HflC and HflK could
CYB_0327	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CYB_0331	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CYB_0332	COG0583	DNA-binding transcription factor activity
CYB_0333	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYB_0338	COG0371	Dehydrogenase
CYB_0340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CYB_0343	COG0284	orotidine-5'-phosphate decarboxylase activity
CYB_0348	COG0509	glycine decarboxylation via glycine cleavage system
CYB_0349	COG0596	Alpha beta hydrolase
CYB_0350	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CYB_0352	COG0745	RESPONSE REGULATOR receiver
CYB_0353	COG0675	Transposase, IS605 OrfB family
CYB_0357	COG0191	fructose-bisphosphate aldolase activity
CYB_0359	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CYB_0360	COG0860	N-Acetylmuramoyl-L-alanine amidase
CYB_0372	COG1615	UPF0182 protein
CYB_0375	COG0746	molybdenum cofactor guanylyltransferase activity
CYB_0378	COG0537	adenosine 5'-monophosphoramidase activity
CYB_0381	COG0426	domain, Protein
CYB_0381	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CYB_0382	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CYB_0393	COG0402	S-adenosylhomocysteine deaminase activity
CYB_0394	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CYB_0399	COG0725	ABC transporter, periplasmic molybdate-binding protein
CYB_0401	COG3585	molybdate ion transport
CYB_0407	COG5420	small protein containing a coiled-coil domain
CYB_0410	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CYB_0414	COG0783	Belongs to the Dps family
CYB_0417	COG0535	radical SAM domain protein
CYB_0417	COG1433	Dinitrogenase iron-molybdenum cofactor
CYB_0418	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
CYB_0421	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CYB_0424	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYB_0431	COG0237	dephospho-CoA kinase activity
CYB_0431	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYB_0432	COG2255	four-way junction helicase activity
CYB_0434	COG1214	PFAM Peptidase M22, glycoprotease
CYB_0435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CYB_0436	COG0511	ligase activity, forming carbon-carbon bonds
CYB_0437	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CYB_0438	COG0175	sulfate reduction
CYB_0441	COG0572	uridine kinase
CYB_0442	COG1842	Phage shock protein A
CYB_0444	COG1218	3'(2'),5'-bisphosphate nucleotidase
CYB_0445	COG0107	imidazoleglycerol-phosphate synthase activity
CYB_0448	COG0228	four-way junction DNA binding
CYB_0450	COG1937	Protein conserved in bacteria
CYB_0451	COG0142	geranyltranstransferase activity
CYB_0455	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CYB_0460	COG0859	PFAM glycosyl transferase family 9
CYB_0463	COG1752	Esterase of the alpha-beta hydrolase superfamily
CYB_0464	COG0406	alpha-ribazole phosphatase activity
CYB_0465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CYB_0466	COG0515	serine threonine protein kinase
CYB_0479	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CYB_0481	COG1253	flavin adenine dinucleotide binding
CYB_0482	COG1982	Orn Lys Arg decarboxylase major
CYB_0491	COG1957	nucleoside hydrolase
CYB_0492	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CYB_0493	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CYB_0494	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CYB_0497	COG1181	Belongs to the D-alanine--D-alanine ligase family
CYB_0500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CYB_0503	COG0454	-acetyltransferase
CYB_0506	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYB_0511	COG0343	queuine tRNA-ribosyltransferase activity
CYB_0515	COG0702	epimerase
CYB_0516	COG1012	belongs to the aldehyde dehydrogenase family
CYB_0518	COG0675	Transposase, IS605 OrfB family
CYB_0519	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CYB_0522	COG0515	serine threonine protein kinase
CYB_0522	COG2815	serine threonine protein kinase
CYB_0523	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CYB_0524	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CYB_0526	COG1027	Aspartate ammonia-lyase
CYB_0528	COG2211	Major facilitator Superfamily
CYB_0533	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYB_0535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CYB_0538	COG0739	heme binding
CYB_0541	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CYB_0545	COG1177	transmembrane transport
CYB_0546	COG0632	four-way junction helicase activity
CYB_0547	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CYB_0549	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYB_0553	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CYB_0556	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CYB_0557	COG0398	Pfam SNARE associated Golgi protein
CYB_0559	COG0251	oxidation-reduction process
CYB_0560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CYB_0561	COG2814	Major facilitator Superfamily
CYB_0562	COG2385	sporulation resulting in formation of a cellular spore
CYB_0566	COG1587	Uroporphyrinogen-III synthase
CYB_0568	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYB_0568	COG0237	dephospho-CoA kinase activity
CYB_0578	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYB_0580	COG0517	IMP dehydrogenase activity
CYB_0580	COG1125	glycine betaine transport
CYB_0584	COG2720	vancomycin resistance protein
CYB_0590	COG1337	RAMP superfamily
CYB_0597	COG2010	Cytochrome c
CYB_0601	COG1116	anion transmembrane transporter activity
CYB_0602	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYB_0602	COG1116	anion transmembrane transporter activity
CYB_0603	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYB_0604	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYB_0607	COG0542	response to heat
CYB_0608	COG0740	serine-type endopeptidase activity
CYB_0610	COG0740	serine-type endopeptidase activity
CYB_0619	COG2010	Cytochrome c
CYB_0623	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYB_0625	COG0785	Cytochrome C biogenesis protein
CYB_0626	COG1333	cytochrome c biogenesis protein
CYB_0631	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYB_0633	COG2385	sporulation resulting in formation of a cellular spore
CYB_0635	COG0590	tRNA wobble adenosine to inosine editing
CYB_0636	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYB_0642	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CYB_0643	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CYB_0646	COG0297	glycogen (starch) synthase activity
CYB_0647	COG1543	Belongs to the glycosyl hydrolase 57 family
CYB_0648	COG0028	Belongs to the TPP enzyme family
CYB_0649	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CYB_0650	COG0673	inositol 2-dehydrogenase activity
CYB_0651	COG1305	Transglutaminase-like
CYB_0652	COG0730	response to heat
CYB_0653	COG0077	Prephenate dehydratase
CYB_0653	COG1605	Chorismate mutase
CYB_0655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CYB_0656	COG0616	signal peptide processing
CYB_0660	COG0109	protoheme IX farnesyltransferase activity
CYB_0662	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYB_0666	COG0170	dolichyl monophosphate biosynthetic process
CYB_0667	COG2010	Cytochrome c
CYB_0669	COG0514	ATP-dependent DNA helicase (RecQ)
CYB_0671	COG0131	Imidazoleglycerol-phosphate dehydratase
CYB_0674	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CYB_0677	COG0366	Alpha amylase catalytic
CYB_0678	COG0758	DNA mediated transformation
CYB_0678	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CYB_0679	COG2135	peptidase activity
CYB_0681	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYB_0683	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CYB_0688	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CYB_0688	COG0662	Cupin 2, conserved barrel domain protein
CYB_0694	COG0124	histidyl-tRNA synthetase
CYB_0701	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CYB_0703	COG0438	transferase activity, transferring glycosyl groups
CYB_0707	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CYB_0708	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CYB_0709	COG0424	maF-like protein
CYB_0710	COG1254	Belongs to the acylphosphatase family
CYB_0714	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CYB_0714	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CYB_0723	COG1716	ATPase activity
CYB_0723	COG5001	Diguanylate cyclase
CYB_0724	COG0475	glutathione-regulated potassium exporter activity
CYB_0725	COG0193	aminoacyl-tRNA hydrolase activity
CYB_0729	COG4948	Mandelate Racemase Muconate Lactonizing
CYB_0732	COG0612	Peptidase, M16
CYB_0733	COG1994	Peptidase M50
CYB_0733	COG0517	IMP dehydrogenase activity
CYB_0735	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CYB_0738	COG1136	(ABC) transporter
CYB_0739	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CYB_0741	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CYB_0742	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CYB_0745	COG0484	heat shock protein binding
CYB_0747	COG2234	aminopeptidase activity
CYB_0748	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CYB_0749	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYB_0752	COG1194	a g-specific adenine glycosylase
CYB_0755	COG0571	ribonuclease III activity
CYB_0759	COG2885	chlorophyll binding
CYB_0765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CYB_0766	COG0456	acetyltransferase
CYB_0769	COG0489	protein tyrosine kinase activity
CYB_0770	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CYB_0776	COG0497	DNA recombination
CYB_0780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYB_0783	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CYB_0784	COG0747	negative chemotaxis
CYB_0786	COG0438	transferase activity, transferring glycosyl groups
CYB_0798	COG1192	Involved in chromosome partitioning
CYB_0801	COG1715	Restriction endonuclease
CYB_0803	COG0415	Belongs to the DNA photolyase family
CYB_0807	COG0556	nucleotide-excision repair
CYB_0808	COG1511	domain protein
CYB_0808	COG3264	Mechanosensitive ion channel
CYB_0813	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
CYB_0814	COG0675	Transposase, IS605 OrfB family
CYB_0816	COG1070	Carbohydrate kinase
CYB_0819	COG0811	peptide transport
CYB_0820	COG0848	biopolymer transport protein
CYB_0821	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CYB_0822	COG0793	Belongs to the peptidase S41A family
CYB_0823	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CYB_0825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CYB_0825	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CYB_0828	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CYB_0828	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CYB_0830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CYB_0832	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CYB_0847	COG0539	negative regulation of cytoplasmic translation
CYB_0848	COG1959	2 iron, 2 sulfur cluster binding
CYB_0849	COG0714	Associated with various cellular activities
CYB_0850	COG0601	transmembrane transport
CYB_0856	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CYB_0857	COG4221	oxidoreductase activity
CYB_0858	COG5002	protein histidine kinase activity
CYB_0864	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYB_0869	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYB_0870	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CYB_0872	COG0649	NAD binding
CYB_0874	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CYB_0877	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CYB_0878	COG0829	nickel cation binding
CYB_0881	COG0596	Alpha beta hydrolase
CYB_0883	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYB_0884	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CYB_0889	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CYB_0890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CYB_0891	COG1666	GTP binding
CYB_0892	COG0300	oxidoreductase activity
CYB_0894	COG1716	ATPase activity
CYB_0894	COG5001	Diguanylate cyclase
CYB_0895	COG0768	penicillin binding
CYB_0896	COG0776	regulation of translation
CYB_0901	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CYB_0905	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CYB_0906	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CYB_0908	COG1429	ligase activity, forming nitrogen-metal bonds
CYB_0909	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CYB_0911	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CYB_0911	COG0189	ligase activity
CYB_0916	COG1040	competence protein
CYB_0917	COG3437	response regulator, receiver
CYB_0918	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CYB_0919	COG0049	tRNA binding
CYB_0920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CYB_0921	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CYB_0922	COG0051	transcription antitermination factor activity, RNA binding
CYB_0924	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CYB_0927	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYB_0929	COG0805	protein transport
CYB_0930	COG0765	amino acid transport
CYB_0931	COG4597	amino acid ABC transporter
CYB_0932	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYB_0933	COG1126	abc transporter atp-binding protein
CYB_0937	COG0159	tryptophan synthase activity
CYB_0941	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CYB_0942	COG1413	lyase activity
CYB_0943	COG1413	lyase activity
CYB_0944	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYB_0945	COG3937	granule-associated protein
CYB_0946	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYB_0947	COG0631	protein serine/threonine phosphatase activity
CYB_0948	COG0123	including yeast histone deacetylase and acetoin utilization protein
CYB_0949	COG0515	serine threonine protein kinase
CYB_0958	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYB_0960	COG3118	belongs to the thioredoxin family
CYB_0966	COG2890	protein-(glutamine-N5) methyltransferase activity
CYB_0970	COG0826	peptidase U32
CYB_0971	COG0440	acetolactate synthase activity
CYB_0974	COG0837	glucose binding
CYB_0976	COG2226	methyltransferase
CYB_0978	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYB_0983	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CYB_0984	COG0616	signal peptide processing
CYB_0985	COG1028	Short-chain dehydrogenase reductase Sdr
CYB_0986	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CYB_0987	COG2205	protein histidine kinase activity
CYB_0987	COG4999	Histidine kinase
CYB_0987	COG3437	response regulator, receiver
CYB_0987	COG3850	Histidine kinase
CYB_0988	COG4956	integral membrane protein (PIN domain superfamily)
CYB_0989	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CYB_0990	COG0750	zinc metalloprotease
CYB_0991	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CYB_0992	COG1660	Displays ATPase and GTPase activities
CYB_0993	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CYB_0996	COG0768	penicillin binding
CYB_0997	COG0463	Glycosyl transferase, family 2
CYB_0998	COG1480	7TM receptor with intracellular HD hydrolase
CYB_1001	COG1316	TRANSCRIPTIONal
CYB_1003	COG0326	Molecular chaperone. Has ATPase activity
CYB_1005	COG0174	glutamine synthetase
CYB_1006	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CYB_1008	COG0745	RESPONSE REGULATOR receiver
CYB_1012	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CYB_1013	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CYB_1016	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CYB_1018	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CYB_1020	COG0406	alpha-ribazole phosphatase activity
CYB_1021	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CYB_1022	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CYB_1026	COG0006	proline dipeptidase activity
CYB_1027	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CYB_1030	COG0009	L-threonylcarbamoyladenylate synthase
CYB_1031	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CYB_1040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CYB_1049	COG0189	ligase activity
CYB_1051	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CYB_1057	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CYB_1060	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CYB_1063	COG0402	S-adenosylhomocysteine deaminase activity
CYB_1066	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYB_1067	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYB_1070	COG2046	Belongs to the sulfate adenylyltransferase family
CYB_1073	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CYB_1074	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CYB_1075	COG0581	inorganic phosphate transmembrane transporter activity
CYB_1076	COG0573	inorganic phosphate transmembrane transporter activity
CYB_1080	COG0359	binds to the 23S rRNA
CYB_1081	COG1372	Participates in initiation and elongation during chromosome replication
CYB_1081	COG0305	Participates in initiation and elongation during chromosome replication
CYB_1083	COG1691	(AIR) carboxylase
CYB_1084	COG0861	Integral membrane protein TerC family
CYB_1086	COG1127	ABC transporter
CYB_1089	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CYB_1092	COG3293	Transposase
CYB_1094	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CYB_1095	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CYB_1100	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CYB_1106	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CYB_1106	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CYB_1107	COG0419	ATPase involved in DNA repair
CYB_1112	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CYB_1113	COG0564	pseudouridine synthase activity
CYB_1115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CYB_1115	COG0574	Belongs to the PEP-utilizing enzyme family
CYB_1117	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CYB_1119	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CYB_1126	COG0442	prolyl-tRNA aminoacylation
CYB_1127	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CYB_1130	COG3437	response regulator, receiver
CYB_1134	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYB_1135	COG0003	Pfam Anion-transporting ATPase
CYB_1141	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CYB_1142	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYB_1145	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CYB_1146	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CYB_1152	COG2211	Major facilitator Superfamily
CYB_1159	COG0628	permease
CYB_1160	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CYB_1161	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CYB_1162	COG0803	Belongs to the bacterial solute-binding protein 9 family
CYB_1163	COG1121	(ABC) transporter
CYB_1164	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYB_1165	COG0724	RNA recognition motif
CYB_1166	COG0357	Ribosomal RNA small subunit methyltransferase G
CYB_1168	COG0519	Catalyzes the synthesis of GMP from XMP
CYB_1168	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CYB_1171	COG0523	cobalamin synthesis protein
CYB_1181	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYB_1183	COG0587	DNA-directed DNA polymerase activity
CYB_1184	COG0709	Synthesizes selenophosphate from selenide and ATP
CYB_1186	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYB_1191	COG0482	sulfurtransferase activity
CYB_1194	COG1357	PFAM Pentapeptide repeats (8 copies)
CYB_1194	COG0515	serine threonine protein kinase
CYB_1196	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CYB_1197	COG1305	Transglutaminase-like
CYB_1200	COG1846	Transcriptional regulator
CYB_1207	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CYB_1208	COG1271	oxidase subunit
CYB_1209	COG1294	oxidase, subunit
CYB_1211	COG0668	transmembrane transport
CYB_1212	COG0456	acetyltransferase
CYB_1214	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CYB_1217	COG0336	Belongs to the RNA methyltransferase TrmD family
CYB_1219	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CYB_1220	COG0250	Participates in transcription elongation, termination and antitermination
CYB_1221	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CYB_1222	COG0081	regulation of translation
CYB_1223	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CYB_1224	COG0222	ribosome binding
CYB_1229	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CYB_1231	COG1192	Involved in chromosome partitioning
CYB_1233	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CYB_1234	COG1132	(ABC) transporter
CYB_1236	COG0505	Belongs to the CarA family
CYB_1242	COG2197	response regulator
CYB_1244	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CYB_1248	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CYB_1248	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYB_1249	COG5002	protein histidine kinase activity
CYB_1251	COG0322	excinuclease ABC activity
CYB_1253	COG0067	glutamate synthase
CYB_1253	COG0069	glutamate synthase activity
CYB_1253	COG0070	glutamate synthase
CYB_1254	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CYB_1261	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
CYB_1262	COG0436	Aminotransferase
CYB_1263	COG1160	GTP binding
CYB_1264	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CYB_1268	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CYB_1269	COG2385	sporulation resulting in formation of a cellular spore
CYB_1269	COG2247	cell wall binding repeat
CYB_1272	COG4968	Prepilin-type N-terminal cleavage methylation domain
CYB_1276	COG3293	Transposase
CYB_1278	COG0713	ATP synthesis coupled electron transport
CYB_1281	COG0095	Lipoate-protein ligase
CYB_1283	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CYB_1289	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYB_1290	COG0275	rRNA processing
CYB_1298	COG1233	COG1233 Phytoene dehydrogenase and related
CYB_1299	COG1176	ABC-type spermidine putrescine transport system, permease component I
CYB_1301	COG3842	ATPase activity
CYB_1304	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CYB_1306	COG0237	dephospho-CoA kinase activity
CYB_1307	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYB_1309	COG1606	tRNA processing
CYB_1316	COG0640	Transcriptional regulator
CYB_1320	COG1331	Highly conserved protein containing a thioredoxin domain
CYB_1321	COG0456	acetyltransferase
CYB_1326	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CYB_1327	COG0275	rRNA processing
CYB_1330	COG4206	TonB-dependent receptor
CYB_1335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CYB_1336	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CYB_1337	COG0569	domain protein
CYB_1338	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CYB_1339	COG0857	belongs to the CobB CobQ family
CYB_1340	COG0328	RNA-DNA hybrid ribonuclease activity
CYB_1344	COG2205	protein histidine kinase activity
CYB_1348	COG2048	Heterodisulfide reductase, subunit B
CYB_1350	COG0217	transcriptional regulatory protein
CYB_1351	COG0393	Putative heavy-metal-binding
CYB_1353	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYB_1354	COG2197	response regulator
CYB_1360	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CYB_1362	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CYB_1363	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CYB_1371	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CYB_1374	COG2133	pyrroloquinoline quinone binding
CYB_1382	COG0285	dihydrofolate synthase activity
CYB_1383	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CYB_1384	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CYB_1390	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CYB_1391	COG0439	Biotin carboxylase
CYB_1394	COG0484	heat shock protein binding
CYB_1400	COG3932	Exopolysaccharide synthesis, ExoD
CYB_1402	COG0719	Fe-S assembly protein
CYB_1403	COG0396	ATPase activity
CYB_1404	COG1970	mechanosensitive ion channel activity
CYB_1405	COG0719	Fe-S assembly protein
CYB_1407	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CYB_1410	COG5002	protein histidine kinase activity
CYB_1414	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CYB_1417	COG0529	Catalyzes the synthesis of activated sulfate
CYB_1419	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CYB_1421	COG0436	Aminotransferase
CYB_1423	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYB_1425	COG0460	homoserine dehydrogenase
CYB_1427	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CYB_1430	COG2223	nitrite transmembrane transporter activity
CYB_1431	COG0673	inositol 2-dehydrogenase activity
CYB_1434	COG0783	Belongs to the Dps family
CYB_1435	COG0463	Glycosyl transferase, family 2
CYB_1436	COG1162	GTPase activity
CYB_1437	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CYB_1441	COG1131	(ABC) transporter
CYB_1444	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CYB_1445	COG1185	polyribonucleotide nucleotidyltransferase activity
CYB_1452	COG0431	NADPH-dependent FMN reductase
CYB_1454	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CYB_1464	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CYB_1467	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CYB_1471	COG1007	ATP synthesis coupled electron transport
CYB_1477	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYB_1478	COG0504	CTP synthase activity
CYB_1480	COG0667	Aldo Keto reductase
CYB_1481	COG2217	Heavy metal translocating P-type atpase
CYB_1485	COG2205	protein histidine kinase activity
CYB_1487	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CYB_1490	COG1640	4-alpha-glucanotransferase
CYB_1492	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CYB_1493	COG0248	Ppx GppA phosphatase
CYB_1503	COG0443	Heat shock 70 kDa protein
CYB_1508	COG0133	tryptophan synthase activity
CYB_1510	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CYB_1511	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CYB_1512	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CYB_1514	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CYB_1515	COG0515	serine threonine protein kinase
CYB_1515	COG1357	PFAM Pentapeptide repeats (8 copies)
CYB_1516	COG2372	response to copper ion
CYB_1520	COG0358	DNA primase activity
CYB_1521	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CYB_1522	COG0515	serine threonine protein kinase
CYB_1522	COG1357	PFAM Pentapeptide repeats (8 copies)
CYB_1530	COG1484	DNA-dependent DNA replication
CYB_1534	COG0052	Belongs to the universal ribosomal protein uS2 family
CYB_1535	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CYB_1536	COG0402	S-adenosylhomocysteine deaminase activity
CYB_1537	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CYB_1539	COG0592	DNA-directed DNA polymerase activity
CYB_1543	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CYB_1545	COG0469	pyruvate kinase activity
CYB_1549	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CYB_1550	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CYB_1554	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYB_1555	COG1136	(ABC) transporter
CYB_1555	COG0577	efflux transmembrane transporter activity
CYB_1556	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYB_1559	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CYB_1560	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CYB_1567	COG3293	Transposase
CYB_1568	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CYB_1570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CYB_1577	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CYB_1578	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CYB_1579	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CYB_1580	COG0202	RNA polymerase activity
CYB_1581	COG0203	ribosomal protein L17
CYB_1582	COG0101	tRNA pseudouridine synthase activity
CYB_1583	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CYB_1584	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CYB_1585	COG0254	rRNA binding
CYB_1586	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CYB_1587	COG1049	propionate catabolic process, 2-methylcitrate cycle
CYB_1589	COG0071	Belongs to the small heat shock protein (HSP20) family
CYB_1590	COG3842	ATPase activity
CYB_1598	COG0633	Ferredoxin
CYB_1605	COG0154	amidase activity
CYB_1607	COG1929	Belongs to the glycerate kinase type-1 family
CYB_1609	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CYB_1611	COG0659	secondary active sulfate transmembrane transporter activity
CYB_1613	COG3659	wide pore channel activity
CYB_1616	COG0516	GMP reductase activity
CYB_1618	COG0459	protein refolding
CYB_1619	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CYB_1621	COG0739	heme binding
CYB_1622	COG0723	plastoquinol--plastocyanin reductase activity
CYB_1628	COG0793	Belongs to the peptidase S41A family
CYB_1629	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CYB_1630	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CYB_1631	COG0473	3-isopropylmalate dehydrogenase activity
CYB_1632	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CYB_1633	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CYB_1634	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CYB_1636	COG1234	tRNA 3'-trailer cleavage
CYB_1638	COG0316	Belongs to the HesB IscA family
CYB_1639	COG0745	RESPONSE REGULATOR receiver
CYB_1640	COG5002	protein histidine kinase activity
CYB_1640	COG0784	Response regulator, receiver
CYB_1640	COG2205	protein histidine kinase activity
CYB_1641	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CYB_1644	COG0019	diaminopimelate decarboxylase activity
CYB_1645	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CYB_1648	COG1104	cysteine desulfurase activity
CYB_1649	COG0772	Belongs to the SEDS family
CYB_1651	COG1129	ABC transporter
CYB_1652	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CYB_1653	COG5001	Diguanylate cyclase
CYB_1653	COG5002	protein histidine kinase activity
CYB_1653	COG3447	MASE1 domain protein
CYB_1655	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CYB_1656	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CYB_1657	COG1131	(ABC) transporter
CYB_1661	COG0589	response to stress
CYB_1662	COG2866	Carboxypeptidase
CYB_1664	COG0360	Binds together with S18 to 16S ribosomal RNA
CYB_1665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYB_1666	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CYB_1668	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CYB_1670	COG0717	Belongs to the dCTP deaminase family
CYB_1673	COG3293	Transposase
CYB_1678	COG0473	3-isopropylmalate dehydrogenase activity
CYB_1680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYB_1683	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYB_1685	COG0501	Belongs to the peptidase M48B family
CYB_1687	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CYB_1689	COG1132	(ABC) transporter
CYB_1691	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYB_1693	COG0126	phosphoglycerate kinase activity
CYB_1694	COG0493	'glutamate synthase
CYB_1694	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CYB_1695	COG1562	ergosterol biosynthetic process
CYB_1696	COG1205	dead DEAH box helicase
CYB_1696	COG1111	helicase
CYB_1700	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CYB_1701	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYB_1704	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CYB_1709	COG0456	acetyltransferase
CYB_1712	COG0459	protein refolding
CYB_1727	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYB_1729	COG4636	protein conserved in cyanobacteria
CYB_1734	COG0297	glycogen (starch) synthase activity
CYB_1737	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CYB_1739	COG0488	(ABC) transporter
CYB_1741	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CYB_1744	COG0010	Belongs to the arginase family
CYB_1746	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CYB_1747	COG1799	cell septum assembly
CYB_1748	COG1252	NADH dehydrogenase
CYB_1749	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CYB_1750	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CYB_1751	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CYB_1752	COG0137	argininosuccinate synthase activity
CYB_1756	COG3293	Transposase
CYB_1757	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYB_1758	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYB_1761	COG0644	oxidoreductase
CYB_1764	COG4372	Transposase
CYB_1765	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYB_1765	COG0022	dehydrogenase e1 component
CYB_1766	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CYB_1772	COG0426	domain, Protein
CYB_1772	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CYB_1773	COG2203	Gaf domain
CYB_1773	COG3706	GGDEF domain
CYB_1773	COG4251	negative regulation of phosphorylation
CYB_1773	COG5001	Diguanylate cyclase
CYB_1779	COG3000	fatty acid hydroxylase
CYB_1779	COG0300	oxidoreductase activity
CYB_1782	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CYB_1783	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CYB_1784	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CYB_1786	COG0181	hydroxymethylbilane synthase activity
CYB_1789	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CYB_1790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CYB_1794	COG4451	ribulose bisphosphate carboxylase, small
CYB_1794	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CYB_1795	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CYB_1796	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CYB_1798	COG1122	ATPase activity
CYB_1803	COG3794	PFAM blue (type 1) copper domain protein
CYB_1806	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CYB_1811	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYB_1812	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYB_1815	COG0352	thiamine-phosphate diphosphorylase activity
CYB_1816	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYB_1817	COG0484	heat shock protein binding
CYB_1818	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CYB_1820	COG0739	heme binding
CYB_1821	COG0215	cysteine-tRNA ligase activity
CYB_1823	COG1530	ribonuclease E activity
CYB_1824	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CYB_1827	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CYB_1839	COG4401	Chorismate mutase type I
CYB_1842	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CYB_1847	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYB_1847	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYB_1861	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CYB_1862	COG0483	inositol monophosphate 1-phosphatase activity
CYB_1863	COG1216	Glycosyl transferase, family 2
CYB_1864	COG0515	serine threonine protein kinase
CYB_1867	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CYB_1868	COG2226	methyltransferase
CYB_1868	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CYB_1868	COG0596	Alpha beta hydrolase
CYB_1875	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CYB_1877	COG1192	Involved in chromosome partitioning
CYB_1878	COG0436	Aminotransferase
CYB_1880	COG2177	Part of the ABC transporter FtsEX involved in
CYB_1883	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYB_1884	COG0601	transmembrane transport
CYB_1886	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CYB_1887	COG2884	Cell division ATP-binding protein ftsE
CYB_1893	COG1012	belongs to the aldehyde dehydrogenase family
CYB_1895	COG2205	protein histidine kinase activity
CYB_1897	COG0739	heme binding
CYB_1898	COG1122	ATPase activity
CYB_1900	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CYB_1901	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CYB_1902	COG0083	homoserine kinase activity
CYB_1903	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CYB_1904	COG1028	Short-chain dehydrogenase reductase Sdr
CYB_1908	COG0372	Belongs to the citrate synthase family
CYB_1909	COG0701	Predicted permease
CYB_1912	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CYB_1913	COG0581	inorganic phosphate transmembrane transporter activity
CYB_1914	COG0573	inorganic phosphate transmembrane transporter activity
CYB_1915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CYB_1917	COG0540	Belongs to the ATCase OTCase family
CYB_1918	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CYB_1921	COG0321	lipoyl(octanoyl) transferase activity
CYB_1922	COG3118	belongs to the thioredoxin family
CYB_1925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYB_1927	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYB_1928	COG0640	Transcriptional regulator
CYB_1930	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CYB_1931	COG1230	cation diffusion facilitator family transporter
CYB_1933	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CYB_1934	COG0643	Histidine kinase
CYB_1934	COG2198	Histidine kinase
CYB_1934	COG0643	Histidine kinase
CYB_1934	COG2198	Histidine kinase
CYB_1935	COG2203	Gaf domain
CYB_1935	COG0840	transmembrane signaling receptor activity
CYB_1941	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CYB_1942	COG2086	electron transfer activity
CYB_1944	COG0018	arginyl-trna synthetase
CYB_1948	COG0583	DNA-binding transcription factor activity
CYB_1949	COG3046	protein related to deoxyribodipyrimidine photolyase
CYB_1950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CYB_1958	COG1741	Belongs to the pirin family
CYB_1959	COG0802	atpase or kinase
CYB_1960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CYB_1961	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CYB_1962	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYB_1963	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CYB_1963	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CYB_1964	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CYB_1965	COG1473	amidohydrolase
CYB_1972	COG3781	membrane
CYB_1975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYB_1977	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYB_1978	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CYB_1980	COG0859	PFAM glycosyl transferase family 9
CYB_1982	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CYB_1983	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CYB_1985	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CYB_1986	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CYB_1987	COG0129	dihydroxy-acid dehydratase activity
CYB_1990	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CYB_1991	COG0644	oxidoreductase
CYB_1993	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CYB_1994	COG2003	Belongs to the UPF0758 family
CYB_1995	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CYB_1997	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CYB_1999	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYB_2004	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYB_2005	COG1446	asparaginase
CYB_2008	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CYB_2012	COG0411	ABC transporter
CYB_2014	COG0559	Belongs to the binding-protein-dependent transport system permease family
CYB_2018	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CYB_2021	COG0066	3-isopropylmalate dehydratase activity
CYB_2023	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CYB_2030	COG1131	(ABC) transporter
CYB_2031	COG0745	RESPONSE REGULATOR receiver
CYB_2037	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYB_2038	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CYB_2039	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CYB_2041	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CYB_2044	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CYB_2045	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CYB_2047	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CYB_2051	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CYB_2051	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CYB_2055	COG1968	undecaprenyl-diphosphatase activity
CYB_2061	COG2226	methyltransferase
CYB_2064	COG2814	Major facilitator Superfamily
CYB_2065	COG0438	transferase activity, transferring glycosyl groups
CYB_2066	COG2208	phosphoserine phosphatase activity
CYB_2067	COG3293	Transposase
CYB_2070	COG0165	Argininosuccinate lyase
CYB_2077	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CYB_2077	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CYB_2078	COG1725	Transcriptional regulator
CYB_2079	COG3842	ATPase activity
CYB_2082	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CYB_2084	COG0559	Belongs to the binding-protein-dependent transport system permease family
CYB_2085	COG3293	Transposase
CYB_2088	COG3119	arylsulfatase activity
CYB_2090	COG1028	Short-chain dehydrogenase reductase Sdr
CYB_2091	COG0405	Gamma-glutamyltransferase
CYB_2092	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CYB_2096	COG0431	NADPH-dependent FMN reductase
CYB_2099	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CYB_2100	COG0210	DNA helicase
CYB_2101	COG0561	phosphatase activity
CYB_2104	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CYB_2107	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYB_2109	COG1181	Belongs to the D-alanine--D-alanine ligase family
CYB_2110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CYB_2112	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CYB_2114	COG2239	Acts as a magnesium transporter
CYB_2116	COG1285	pathogenesis
CYB_2118	COG2119	membrane
CYB_2119	COG0792	nuclease activity
CYB_2120	COG3688	RNA-binding protein containing a PIN domain
CYB_2123	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CYB_2125	COG0765	amino acid transport
CYB_2127	COG1053	succinate dehydrogenase
CYB_2131	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CYB_2132	COG0242	peptide deformylase activity
CYB_2143	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CYB_2145	COG4948	Mandelate Racemase Muconate Lactonizing
CYB_2149	COG0024	Methionine aminopeptidase
CYB_2151	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CYB_2152	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CYB_2153	COG4447	cellulose binding
CYB_2155	COG5001	Diguanylate cyclase
CYB_2155	COG1716	ATPase activity
CYB_2157	COG0149	triose-phosphate isomerase activity
CYB_2160	COG0501	Belongs to the peptidase M48B family
CYB_2161	COG1132	(ABC) transporter
CYB_2165	COG0039	L-malate dehydrogenase activity
CYB_2166	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CYB_2169	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYB_2170	COG0483	inositol monophosphate 1-phosphatase activity
CYB_2173	COG1492	cobalamin metabolic process
CYB_2175	COG0247	lactate metabolic process
CYB_2181	COG1022	Amp-dependent synthetase and ligase
CYB_2184	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CYB_2186	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CYB_2190	COG1366	Belongs to the anti-sigma-factor antagonist family
CYB_2193	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CYB_2194	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CYB_2195	COG1324	tolerance protein
CYB_2196	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CYB_2202	COG0196	riboflavin kinase activity
CYB_2203	COG0314	molybdopterin synthase activity
CYB_2204	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CYB_2206	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYB_2208	COG1410	methionine synthase
CYB_2208	COG0646	methionine synthase
CYB_2209	COG1177	transmembrane transport
CYB_2212	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CYB_2213	COG0697	spore germination
CYB_2214	COG0180	Tryptophanyl-tRNA synthetase
CYB_2216	COG0457	Tetratricopeptide repeat
CYB_2217	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CYB_2220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYB_2222	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CYB_2227	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CYB_2229	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYB_2237	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYB_2241	COG0706	membrane insertase activity
CYB_2243	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CYB_2245	COG0195	Participates in both transcription termination and antitermination
CYB_2246	COG0779	Required for maturation of 30S ribosomal subunits
CYB_2250	COG3293	Transposase
CYB_2251	COG2226	methyltransferase
CYB_2252	COG0010	Belongs to the arginase family
CYB_2254	COG0450	alkyl hydroperoxide reductase
CYB_2257	COG1494	fructose-1,6-bisphosphatase
CYB_2258	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CYB_2263	COG0675	Transposase, IS605 OrfB family
CYB_2264	COG0589	response to stress
CYB_2265	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CYB_2267	COG0716	FMN binding
CYB_2269	COG3487	Iron-regulated protein
CYB_2270	COG3128	pkhd-type hydroxylase
CYB_2273	COG0398	Pfam SNARE associated Golgi protein
CYB_2274	COG4106	trans-aconitate 2-methyltransferase activity
CYB_2277	COG3706	GGDEF domain
CYB_2277	COG0745	RESPONSE REGULATOR receiver
CYB_2278	COG4243	Vitamin k epoxide reductase
CYB_2279	COG0434	BtpA family
CYB_2280	COG0167	dihydroorotate dehydrogenase activity
CYB_2284	COG0501	Belongs to the peptidase M48B family
CYB_2285	COG0735	belongs to the Fur family
CYB_2289	COG2119	membrane
CYB_2290	COG2119	membrane
CYB_2292	COG0528	UMP kinase activity
CYB_2293	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CYB_2294	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CYB_2296	COG0583	DNA-binding transcription factor activity
CYB_2297	COG0596	Alpha beta hydrolase
CYB_2298	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CYB_2300	COG1575	Belongs to the MenA family. Type 1 subfamily
CYB_2304	COG0033	Phosphoglucomutase
CYB_2309	COG0668	transmembrane transport
CYB_2315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CYB_2316	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CYB_2318	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CYB_2319	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CYB_2320	COG1702	phosphate starvation-inducible protein PhoH
CYB_2328	COG0445	tRNA wobble uridine modification
CYB_2332	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYB_2333	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYB_2334	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYB_2338	COG1472	Belongs to the glycosyl hydrolase 3 family
CYB_2339	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CYB_2340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CYB_2341	COG0416	fatty acid biosynthetic process
CYB_2343	COG0134	indole-3-glycerol-phosphate synthase activity
CYB_2346	COG2217	Heavy metal translocating P-type atpase
CYB_2347	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
CYB_2350	COG0009	L-threonylcarbamoyladenylate synthase
CYB_2352	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CYB_2353	COG0539	negative regulation of cytoplasmic translation
CYB_2356	COG0523	cobalamin synthesis protein
CYB_2358	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CYB_2361	COG1032	radical SAM domain protein
CYB_2362	COG1950	PFAM Membrane protein of
CYB_2364	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CYB_2365	COG0798	PFAM Bile acid sodium symporter
CYB_2366	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CYB_2368	COG0037	tRNA processing
CYB_2369	COG1420	regulation of RNA biosynthetic process
CYB_2370	COG0831	urea catabolic process
CYB_2373	COG1193	negative regulation of DNA recombination
CYB_2374	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CYB_2383	COG1137	ATPase activity
CYB_2384	COG0469	pyruvate kinase activity
CYB_2389	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CYB_2391	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYB_2394	COG2104	thiamine diphosphate biosynthetic process
CYB_2395	COG2022	thiamine diphosphate biosynthetic process
CYB_2396	COG2226	methyltransferase
CYB_2399	COG0438	transferase activity, transferring glycosyl groups
CYB_2400	COG1131	(ABC) transporter
CYB_2402	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CYB_2403	COG2226	methyltransferase
CYB_2404	COG1573	uracil-dna glycosylase
CYB_2405	COG0312	modulator of DNA gyrase
CYB_2407	COG3293	Transposase
CYB_2411	COG0312	modulator of DNA gyrase
CYB_2417	COG0512	Glutamine amidotransferase of anthranilate synthase
CYB_2417	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYB_2421	COG5002	protein histidine kinase activity
CYB_2425	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CYB_2425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CYB_2432	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CYB_2433	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CYB_2435	COG5398	heme oxygenase
CYB_2436	COG0085	RNA polymerase activity
CYB_2437	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CYB_2438	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CYB_2439	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CYB_2439	COG0351	phosphomethylpyrimidine kinase
CYB_2439	COG0352	thiamine-phosphate diphosphorylase activity
CYB_2441	COG5322	oxidoreductase activity
CYB_2442	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CYB_2446	COG1116	anion transmembrane transporter activity
CYB_2447	COG0788	formyltetrahydrofolate deformylase activity
CYB_2449	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYB_2451	COG0653	protein targeting
CYB_2452	COG1090	epimerase
CYB_2456	COG0113	porphobilinogen synthase activity
CYB_2461	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYB_2462	COG0483	inositol monophosphate 1-phosphatase activity
CYB_2464	COG0084	hydrolase, TatD family'
CYB_2465	COG5001	Diguanylate cyclase
CYB_2465	COG2203	Gaf domain
CYB_2465	COG4251	negative regulation of phosphorylation
CYB_2465	COG3706	GGDEF domain
CYB_2471	COG5002	protein histidine kinase activity
CYB_2474	COG3293	Transposase
CYB_2478	COG1175	transmembrane transport
CYB_2480	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CYB_2481	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CYB_2482	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CYB_2489	COG1191	sigma factor activity
CYB_2492	COG1077	Cell shape determining protein MreB Mrl
CYB_2496	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYB_2498	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CYB_2499	COG1959	2 iron, 2 sulfur cluster binding
CYB_2500	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CYB_2501	COG0745	RESPONSE REGULATOR receiver
CYB_2502	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CYB_2505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CYB_2506	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CYB_2511	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CYB_2512	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CYB_2515	COG0515	serine threonine protein kinase
CYB_2516	COG0589	response to stress
CYB_2516	COG0475	glutathione-regulated potassium exporter activity
CYB_2517	COG0751	glycine-tRNA ligase activity
CYB_2524	COG0542	response to heat
CYB_2525	COG0557	exoribonuclease II activity
CYB_2526	COG0704	Plays a role in the regulation of phosphate uptake
CYB_2531	COG0148	phosphopyruvate hydratase activity
CYB_2532	COG1505	serine-type exopeptidase activity
CYB_2537	COG2010	Cytochrome c
CYB_2539	COG2010	Cytochrome c
CYB_2541	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CYB_2542	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CYB_2545	COG0375	protein maturation
CYB_2548	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CYB_2550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYB_2552	COG0557	exoribonuclease II activity
CYB_2553	COG0745	RESPONSE REGULATOR receiver
CYB_2555	COG0583	DNA-binding transcription factor activity
CYB_2558	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CYB_2559	COG1381	Involved in DNA repair and RecF pathway recombination
CYB_2561	COG0745	RESPONSE REGULATOR receiver
CYB_2567	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CYB_2568	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CYB_2570	COG0735	belongs to the Fur family
CYB_2572	COG0484	heat shock protein binding
CYB_2574	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYB_2575	COG0515	serine threonine protein kinase
CYB_2575	COG2815	serine threonine protein kinase
CYB_2576	COG1836	PFAM Integral membrane protein DUF92
CYB_2577	COG4451	ribulose bisphosphate carboxylase, small
CYB_2579	COG1850	ribulose-bisphosphate carboxylase activity
CYB_2581	COG0740	serine-type endopeptidase activity
CYB_2586	COG1797	cobyrinic acid a,c-diamide synthase activity
CYB_2590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CYB_2592	COG3293	Transposase
CYB_2593	COG0521	Mo-molybdopterin cofactor biosynthetic process
CYB_2597	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CYB_2598	COG0088	Forms part of the polypeptide exit tunnel
CYB_2599	COG0089	rRNA binding
CYB_2600	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CYB_2601	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CYB_2602	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CYB_2603	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CYB_2604	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CYB_2605	COG0255	Belongs to the universal ribosomal protein uL29 family
CYB_2606	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CYB_2607	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CYB_2608	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CYB_2609	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CYB_2610	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CYB_2611	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CYB_2612	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CYB_2613	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CYB_2614	COG0200	Binds to the 23S rRNA
CYB_2615	COG0201	protein transport
CYB_2616	COG0563	adenylate kinase activity
CYB_2617	COG0024	Methionine aminopeptidase
CYB_2618	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CYB_2622	COG0438	transferase activity, transferring glycosyl groups
CYB_2625	COG3854	ATPases associated with a variety of cellular activities
CYB_2628	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYB_2629	COG0672	)-iron permease
CYB_2631	COG1122	ATPase activity
CYB_2635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CYB_2638	COG3293	Transposase
CYB_2643	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CYB_2647	COG0354	folic acid binding
CYB_2652	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYB_2662	COG3293	Transposase
CYB_2665	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CYB_2666	COG1366	Belongs to the anti-sigma-factor antagonist family
CYB_2667	COG2226	methyltransferase
CYB_2669	COG1840	ABC-type Fe3 transport system, periplasmic component
CYB_2671	COG1178	ABC-type Fe3 transport system permease component
CYB_2672	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CYB_2673	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CYB_2674	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYB_2675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CYB_2677	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYB_2679	COG0356	it plays a direct role in the translocation of protons across the membrane
CYB_2684	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CYB_2686	COG0783	Belongs to the Dps family
CYB_2687	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CYB_2689	COG0745	RESPONSE REGULATOR receiver
CYB_2691	COG1304	FMN binding
CYB_2695	COG0277	FAD linked oxidase domain protein
CYB_2696	COG0675	Transposase, IS605 OrfB family
CYB_2698	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CYB_2700	COG1845	cytochrome c oxidase, subunit III
CYB_2704	COG0347	Belongs to the P(II) protein family
CYB_2705	COG0004	ammonium transporteR
CYB_2706	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CYB_2714	COG0675	Transposase, IS605 OrfB family
CYB_2718	COG0606	chelatase, subunit chli
CYB_2719	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CYB_2722	COG5002	protein histidine kinase activity
CYB_2723	COG0745	RESPONSE REGULATOR receiver
CYB_2728	COG1120	ATPase activity
CYB_2729	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYB_2731	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CYB_2733	COG0728	peptidoglycan biosynthetic process
CYB_2734	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYB_2736	COG1413	lyase activity
CYB_2747	COG0494	nUDIX hydrolase
CYB_2748	COG0784	Response regulator, receiver
CYB_2751	COG2203	Gaf domain
CYB_2751	COG0840	transmembrane signaling receptor activity
CYB_2752	COG0643	Histidine kinase
CYB_2752	COG0643	Histidine kinase
CYB_2752	COG2198	Histidine kinase
CYB_2752	COG2198	Histidine kinase
CYB_2755	COG0825	malonyl-CoA metabolic process
CYB_2756	COG1555	photosystem II stabilization
CYB_2757	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CYB_2759	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CYB_2767	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CYB_2774	COG0724	RNA recognition motif
CYB_2775	COG0420	3'-5' exonuclease activity
CYB_2779	COG1166	arginine decarboxylase activity
CYB_2781	COG0443	Heat shock 70 kDa protein
CYB_2782	COG0484	heat shock protein binding
CYB_2783	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CYB_2785	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CYB_2786	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CYB_2788	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CYB_2791	COG2205	protein histidine kinase activity
CYB_2791	COG0784	Response regulator, receiver
CYB_2795	COG5002	protein histidine kinase activity
CYB_2798	COG0268	Binds directly to 16S ribosomal RNA
CYB_2799	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CYB_2804	COG0174	glutamine synthetase
CYB_2806	COG0492	ferredoxin-NADP+ reductase activity
CYB_2807	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CYB_2808	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CYB_2810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CYB_2813	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CYB_2817	COG2094	Belongs to the DNA glycosylase MPG family
CYB_2818	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CYB_2819	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CYB_2820	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CYB_2822	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CYB_2823	COG0445	tRNA wobble uridine modification
CYB_2828	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CYB_2829	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYB_2833	COG0351	phosphomethylpyrimidine kinase
CYB_2837	COG0408	coproporphyrinogen oxidase activity
CYB_2845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYB_2846	COG0277	FAD linked oxidase domain protein
CYB_2847	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYB_2848	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CYB_2849	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CYB_2850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYB_2851	COG0138	bifunctional purine biosynthesis protein purh
CYB_2854	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYB_2856	COG0745	RESPONSE REGULATOR receiver
CYB_2857	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYB_2860	COG0315	cyclic pyranopterin monophosphate synthase activity
CYB_2863	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CYB_2864	COG2308	Evidence 4 Homologs of previously reported genes of
CYB_2873	COG2154	pterin-4-alpha-carbinolamine dehydratase
CYB_2874	COG1090	epimerase
CYB_2875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYB_2876	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYB_2878	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CYB_2880	COG0312	modulator of DNA gyrase
CYB_2881	COG0495	leucyl-tRNA aminoacylation
CYB_2882	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CYB_2883	COG0572	uridine kinase
CYB_2885	COG0363	glucosamine-6-phosphate deaminase activity
CYB_2889	COG0335	large ribosomal subunit rRNA binding
CYB_2890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYB_2891	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CYB_2892	COG1136	(ABC) transporter
CYB_2892	COG0577	efflux transmembrane transporter activity
CYB_2893	COG0395	ABC-type sugar transport system, permease component
CYB_2894	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CYB_2895	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CYB_2897	COG0233	cytoplasmic translational termination
CYB_2898	COG0617	tRNA 3'-terminal CCA addition
CYB_2901	COG3956	TIGRFAM MazG family protein
CYB_2904	COG1160	GTP binding
CYB_2905	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CYB_2912	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CYB_2913	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CYB_2915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYB_2916	COG0072	phenylalanine-tRNA ligase activity
CYB_2918	COG3409	Peptidoglycan-binding domain 1 protein
CYB_2918	COG3429	Glucose-6-phosphate dehydrogenase subunit
CYB_2919	COG0166	Belongs to the GPI family
CYB_2920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CYB_2922	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CYB_2924	COG0012	GTP binding
CYB_2925	COG0675	Transposase, IS605 OrfB family
CYB_2926	COG0745	RESPONSE REGULATOR receiver
CYB_2928	COG0667	Aldo Keto reductase
CYB_2931	COG4399	Belongs to the UPF0754 family
CYB_2932	COG0737	Belongs to the 5'-nucleotidase family
CYB_2933	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CYB_2934	COG0443	Heat shock 70 kDa protein
CYB_2935	COG0484	heat shock protein binding
CYB_2940	COG1196	nuclear chromosome segregation
CYB_2941	COG0594	ribonuclease P activity
CYB_2942	COG0230	Belongs to the bacterial ribosomal protein bL34 family