locus-tag	class	description
CYA_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CYA_0002	COG2226	methyltransferase
CYA_0004	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYA_0005	COG0300	oxidoreductase activity
CYA_0008	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CYA_0009	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYA_0011	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CYA_0014	COG0515	serine threonine protein kinase
CYA_0017	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CYA_0019	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CYA_0021	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CYA_0022	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CYA_0024	COG0012	GTP binding
CYA_0025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CYA_0027	COG0633	Ferredoxin
CYA_0030	COG0735	belongs to the Fur family
CYA_0034	COG2119	membrane
CYA_0042	COG0515	serine threonine protein kinase
CYA_0046	COG0482	sulfurtransferase activity
CYA_0051	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYA_0055	COG0709	Synthesizes selenophosphate from selenide and ATP
CYA_0057	COG0587	DNA-directed DNA polymerase activity
CYA_0058	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYA_0072	COG0644	oxidoreductase
CYA_0074	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYA_0075	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYA_0077	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CYA_0079	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CYA_0081	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CYA_0082	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CYA_0084	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CYA_0087	COG1968	undecaprenyl-diphosphatase activity
CYA_0088	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CYA_0088	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CYA_0094	COG2226	methyltransferase
CYA_0099	COG0438	transferase activity, transferring glycosyl groups
CYA_0100	COG2208	phosphoserine phosphatase activity
CYA_0103	COG0165	Argininosuccinate lyase
CYA_0107	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CYA_0109	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CYA_0110	COG1181	Belongs to the D-alanine--D-alanine ligase family
CYA_0112	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYA_0114	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CYA_0118	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CYA_0125	COG0724	RNA recognition motif
CYA_0126	COG0420	3'-5' exonuclease activity
CYA_0128	COG1166	arginine decarboxylase activity
CYA_0130	COG0443	Heat shock 70 kDa protein
CYA_0131	COG0247	lactate metabolic process
CYA_0132	COG0484	heat shock protein binding
CYA_0133	COG1022	Amp-dependent synthetase and ligase
CYA_0142	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYA_0143	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CYA_0146	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CYA_0147	COG2884	Cell division ATP-binding protein ftsE
CYA_0148	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CYA_0150	COG0601	transmembrane transport
CYA_0151	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYA_0154	COG2177	Part of the ABC transporter FtsEX involved in
CYA_0161	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CYA_0164	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYA_0166	COG2226	methyltransferase
CYA_0167	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CYA_0169	COG0314	molybdopterin synthase activity
CYA_0171	COG0746	molybdenum cofactor guanylyltransferase activity
CYA_0171	COG0315	cyclic pyranopterin monophosphate synthase activity
CYA_0172	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CYA_0173	COG0303	'Molybdopterin
CYA_0178	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CYA_0180	COG0542	response to heat
CYA_0181	COG0557	exoribonuclease II activity
CYA_0182	COG0704	Plays a role in the regulation of phosphate uptake
CYA_0188	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CYA_0193	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CYA_0194	COG1132	(ABC) transporter
CYA_0195	COG0505	Belongs to the CarA family
CYA_0201	COG2197	response regulator
CYA_0203	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CYA_0206	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYA_0206	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CYA_0207	COG0322	excinuclease ABC activity
CYA_0209	COG0515	serine threonine protein kinase
CYA_0211	COG0123	including yeast histone deacetylase and acetoin utilization protein
CYA_0212	COG0631	protein serine/threonine phosphatase activity
CYA_0213	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYA_0214	COG3937	granule-associated protein
CYA_0215	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYA_0216	COG1413	lyase activity
CYA_0217	COG1413	lyase activity
CYA_0218	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CYA_0223	COG0159	tryptophan synthase activity
CYA_0228	COG1126	abc transporter atp-binding protein
CYA_0235	COG0300	oxidoreductase activity
CYA_0235	COG3000	fatty acid hydroxylase
CYA_0238	COG4106	trans-aconitate 2-methyltransferase activity
CYA_0239	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CYA_0240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CYA_0243	COG0181	hydroxymethylbilane synthase activity
CYA_0246	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CYA_0247	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CYA_0249	COG0501	Belongs to the peptidase M48B family
CYA_0251	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CYA_0252	COG0785	Cytochrome C biogenesis protein
CYA_0253	COG5001	Diguanylate cyclase
CYA_0253	COG4251	negative regulation of phosphorylation
CYA_0253	COG3706	GGDEF domain
CYA_0253	COG2203	Gaf domain
CYA_0254	COG1333	cytochrome c biogenesis protein
CYA_0255	COG0277	FAD linked oxidase domain protein
CYA_0258	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CYA_0263	COG0366	Alpha amylase catalytic
CYA_0267	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CYA_0268	COG0747	negative chemotaxis
CYA_0270	COG0297	glycogen (starch) synthase activity
CYA_0277	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CYA_0278	COG0242	peptide deformylase activity
CYA_0283	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYA_0285	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CYA_0286	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CYA_0287	COG0351	phosphomethylpyrimidine kinase
CYA_0289	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CYA_0291	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYA_0292	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CYA_0296	COG0445	tRNA wobble uridine modification
CYA_0297	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CYA_0298	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CYA_0299	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CYA_0300	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CYA_0301	COG2094	Belongs to the DNA glycosylase MPG family
CYA_0303	COG0415	Belongs to the DNA photolyase family
CYA_0305	COG0776	regulation of translation
CYA_0309	COG0072	phenylalanine-tRNA ligase activity
CYA_0310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CYA_0311	COG1132	(ABC) transporter
CYA_0313	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYA_0315	COG0126	phosphoglycerate kinase activity
CYA_0316	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CYA_0316	COG0493	'glutamate synthase
CYA_0317	COG1562	ergosterol biosynthetic process
CYA_0318	COG1111	helicase
CYA_0318	COG1205	dead DEAH box helicase
CYA_0322	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYA_0325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CYA_0330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYA_0330	COG2022	thiamine diphosphate biosynthetic process
CYA_0332	COG0459	protein refolding
CYA_0333	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CYA_0335	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CYA_0336	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CYA_0337	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CYA_0339	COG0133	tryptophan synthase activity
CYA_0343	COG0443	Heat shock 70 kDa protein
CYA_0348	COG0561	phosphatase activity
CYA_0349	COG0210	DNA helicase
CYA_0350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CYA_0352	COG0431	NADPH-dependent FMN reductase
CYA_0358	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CYA_0359	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CYA_0360	COG0424	maF-like protein
CYA_0361	COG1254	Belongs to the acylphosphatase family
CYA_0362	COG1254	Belongs to the acylphosphatase family
CYA_0365	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CYA_0365	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CYA_0368	COG1077	Cell shape determining protein MreB Mrl
CYA_0371	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_0373	COG0515	serine threonine protein kinase
CYA_0374	COG1216	Glycosyl transferase, family 2
CYA_0375	COG0483	inositol monophosphate 1-phosphatase activity
CYA_0376	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CYA_0380	COG2912	Transglutaminase-like superfamily
CYA_0386	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYA_0386	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYA_0387	COG0166	Belongs to the GPI family
CYA_0388	COG3429	Glucose-6-phosphate dehydrogenase subunit
CYA_0388	COG3409	Peptidoglycan-binding domain 1 protein
CYA_0389	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYA_0391	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CYA_0392	COG0656	L-ascorbic acid biosynthetic process
CYA_0398	COG0149	triose-phosphate isomerase activity
CYA_0401	COG0501	Belongs to the peptidase M48B family
CYA_0402	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYA_0403	COG1132	(ABC) transporter
CYA_0405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CYA_0406	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CYA_0408	COG5398	heme oxygenase
CYA_0409	COG0085	RNA polymerase activity
CYA_0410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CYA_0411	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CYA_0412	COG1573	uracil-dna glycosylase
CYA_0413	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CYA_0413	COG0351	phosphomethylpyrimidine kinase
CYA_0413	COG0352	thiamine-phosphate diphosphorylase activity
CYA_0414	COG5322	oxidoreductase activity
CYA_0415	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CYA_0420	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CYA_0422	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CYA_0423	COG1959	2 iron, 2 sulfur cluster binding
CYA_0424	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CYA_0426	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYA_0428	COG0475	glutathione-regulated potassium exporter activity
CYA_0429	COG1716	ATPase activity
CYA_0429	COG5001	Diguanylate cyclase
CYA_0448	COG1192	Involved in chromosome partitioning
CYA_0456	COG0779	Required for maturation of 30S ribosomal subunits
CYA_0457	COG0195	Participates in both transcription termination and antitermination
CYA_0458	COG0163	prenyltransferase activity
CYA_0461	COG2082	Precorrin-8x methylmutase
CYA_0465	COG1489	DNA binding
CYA_0466	COG0708	Exodeoxyribonuclease III
CYA_0467	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYA_0468	COG4208	sulfate ABC transporter
CYA_0469	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CYA_0470	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CYA_0471	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CYA_0473	COG1012	belongs to the aldehyde dehydrogenase family
CYA_0473	COG1454	alcohol dehydrogenase
CYA_0475	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CYA_0478	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CYA_0479	COG0745	RESPONSE REGULATOR receiver
CYA_0480	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CYA_0481	COG0596	Alpha beta hydrolase
CYA_0482	COG0509	glycine decarboxylation via glycine cleavage system
CYA_0485	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CYA_0486	COG1230	cation diffusion facilitator family transporter
CYA_0490	COG0632	four-way junction helicase activity
CYA_0491	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CYA_0492	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_0496	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CYA_0499	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYA_0500	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CYA_0504	COG0140	phosphoribosyl-ATP diphosphatase activity
CYA_0504	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CYA_0505	COG1649	PFAM Uncharacterised BCR, COG1649
CYA_0505	COG0726	polysaccharide deacetylase
CYA_0511	COG0724	RNA recognition motif
CYA_0512	COG0525	valine-tRNA ligase activity
CYA_0513	COG0789	Transcriptional regulator
CYA_0516	COG0575	Belongs to the CDS family
CYA_0519	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CYA_0520	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_0528	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYA_0528	COG0237	dephospho-CoA kinase activity
CYA_0529	COG1587	Uroporphyrinogen-III synthase
CYA_0531	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CYA_0531	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CYA_0532	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CYA_0534	COG2226	methyltransferase
CYA_0535	COG0010	Belongs to the arginase family
CYA_0537	COG0450	alkyl hydroperoxide reductase
CYA_0542	COG1494	fructose-1,6-bisphosphatase
CYA_0543	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CYA_0548	COG0456	acetyltransferase
CYA_0553	COG0489	protein tyrosine kinase activity
CYA_0554	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CYA_0558	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CYA_0559	COG0271	Belongs to the BolA IbaG family
CYA_0560	COG1950	PFAM Membrane protein of
CYA_0561	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CYA_0563	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CYA_0565	COG0237	dephospho-CoA kinase activity
CYA_0566	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYA_0568	COG1606	tRNA processing
CYA_0574	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CYA_0575	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CYA_0576	COG0123	including yeast histone deacetylase and acetoin utilization protein
CYA_0580	COG0799	negative regulation of ribosome biogenesis
CYA_0582	COG0481	GTPase activity
CYA_0589	COG0436	Aminotransferase
CYA_0597	COG1191	sigma factor activity
CYA_0603	COG0804	urea catabolic process
CYA_0604	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CYA_0605	COG0830	nickel cation binding
CYA_0606	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CYA_0607	COG0829	nickel cation binding
CYA_0613	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYA_0614	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYA_0615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYA_0615	COG1116	anion transmembrane transporter activity
CYA_0616	COG1116	anion transmembrane transporter activity
CYA_0619	COG0243	molybdopterin cofactor binding
CYA_0622	COG0151	Belongs to the GarS family
CYA_0624	COG1078	dGTPase activity
CYA_0626	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CYA_0627	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYA_0628	COG0778	Nitroreductase
CYA_0630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYA_0632	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CYA_0634	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CYA_0636	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CYA_0637	COG2205	protein histidine kinase activity
CYA_0639	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_0640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYA_0646	COG0047	phosphoribosylformylglycinamidine synthase activity
CYA_0647	COG0784	Response regulator, receiver
CYA_0648	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CYA_0651	COG2045	Belongs to the ComB family
CYA_0652	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CYA_0656	COG0542	response to heat
CYA_0657	COG0740	serine-type endopeptidase activity
CYA_0659	COG0740	serine-type endopeptidase activity
CYA_0668	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CYA_0672	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CYA_0673	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CYA_0675	COG2239	Acts as a magnesium transporter
CYA_0677	COG1285	pathogenesis
CYA_0678	COG2119	membrane
CYA_0680	COG0792	nuclease activity
CYA_0681	COG3688	RNA-binding protein containing a PIN domain
CYA_0684	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CYA_0685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYA_0686	COG0765	amino acid transport
CYA_0688	COG1053	succinate dehydrogenase
CYA_0692	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CYA_0693	COG1160	GTP binding
CYA_0697	COG3956	TIGRFAM MazG family protein
CYA_0702	COG0617	tRNA 3'-terminal CCA addition
CYA_0703	COG0233	cytoplasmic translational termination
CYA_0705	COG2010	Cytochrome c
CYA_0706	COG2119	membrane
CYA_0707	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CYA_0708	COG0792	nuclease activity
CYA_0709	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CYA_0710	COG0137	argininosuccinate synthase activity
CYA_0714	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CYA_0718	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CYA_0719	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYA_0721	COG0419	ATPase involved in DNA repair
CYA_0725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CYA_0728	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CYA_0740	COG0564	pseudouridine synthase activity
CYA_0741	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CYA_0741	COG0574	Belongs to the PEP-utilizing enzyme family
CYA_0744	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_0745	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CYA_0747	COG0649	NAD binding
CYA_0749	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CYA_0753	COG0829	nickel cation binding
CYA_0756	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CYA_0759	COG0552	protein localization to endoplasmic reticulum
CYA_0760	COG0788	formyltetrahydrofolate deformylase activity
CYA_0761	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYA_0762	COG0653	protein targeting
CYA_0765	COG0826	peptidase U32
CYA_0768	COG2062	phosphohistidine phosphatase, SixA
CYA_0769	COG3118	belongs to the thioredoxin family
CYA_0771	COG0135	phosphoribosylanthranilate isomerase activity
CYA_0773	COG1187	pseudouridine synthase activity
CYA_0776	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CYA_0780	COG0415	Belongs to the DNA photolyase family
CYA_0782	COG1305	Transglutaminase-like
CYA_0784	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CYA_0785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CYA_0787	COG0443	Heat shock 70 kDa protein
CYA_0788	COG0484	heat shock protein binding
CYA_0789	COG0425	Belongs to the sulfur carrier protein TusA family
CYA_0789	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYA_0790	COG1162	GTPase activity
CYA_0795	COG2205	protein histidine kinase activity
CYA_0798	COG0328	RNA-DNA hybrid ribonuclease activity
CYA_0799	COG0857	belongs to the CobB CobQ family
CYA_0800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CYA_0801	COG0569	domain protein
CYA_0802	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CYA_0803	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CYA_0804	COG0571	ribonuclease III activity
CYA_0815	COG0436	Aminotransferase
CYA_0821	COG1530	ribonuclease E activity
CYA_0822	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CYA_0838	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CYA_0840	COG0784	Response regulator, receiver
CYA_0840	COG2205	protein histidine kinase activity
CYA_0844	COG0024	Methionine aminopeptidase
CYA_0845	COG0038	chloride channel
CYA_0846	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CYA_0847	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CYA_0848	COG4447	cellulose binding
CYA_0850	COG1716	ATPase activity
CYA_0850	COG5001	Diguanylate cyclase
CYA_0852	COG0439	Biotin carboxylase
CYA_0856	COG0484	heat shock protein binding
CYA_0859	COG0010	Belongs to the arginase family
CYA_0860	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CYA_0861	COG1799	cell septum assembly
CYA_0862	COG1252	NADH dehydrogenase
CYA_0863	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CYA_0869	COG0408	coproporphyrinogen oxidase activity
CYA_0870	COG0400	carboxylic ester hydrolase activity
CYA_0877	COG1337	RAMP superfamily
CYA_0891	COG1116	anion transmembrane transporter activity
CYA_0892	COG1116	anion transmembrane transporter activity
CYA_0892	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYA_0893	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYA_0894	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYA_0895	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CYA_0902	COG1366	Belongs to the anti-sigma-factor antagonist family
CYA_0907	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CYA_0908	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CYA_0910	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CYA_0911	COG1660	Displays ATPase and GTPase activities
CYA_0912	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CYA_0913	COG0750	zinc metalloprotease
CYA_0914	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CYA_0915	COG4956	integral membrane protein (PIN domain superfamily)
CYA_0916	COG3850	Histidine kinase
CYA_0916	COG2205	protein histidine kinase activity
CYA_0916	COG4999	Histidine kinase
CYA_0916	COG3437	response regulator, receiver
CYA_0917	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CYA_0918	COG1028	Short-chain dehydrogenase reductase Sdr
CYA_0919	COG0616	signal peptide processing
CYA_0925	COG0268	Binds directly to 16S ribosomal RNA
CYA_0929	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CYA_0935	COG1666	GTP binding
CYA_0936	COG0300	oxidoreductase activity
CYA_0938	COG1716	ATPase activity
CYA_0938	COG5001	Diguanylate cyclase
CYA_0939	COG0768	penicillin binding
CYA_0940	COG0776	regulation of translation
CYA_0941	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYA_0944	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYA_0946	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CYA_0947	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CYA_0948	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CYA_0950	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CYA_0951	COG4178	(ABC) transporter
CYA_0952	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CYA_0960	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CYA_0961	COG0772	Belongs to the SEDS family
CYA_0964	COG0596	Alpha beta hydrolase
CYA_0966	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYA_0967	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CYA_0969	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CYA_0971	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CYA_0972	COG0737	Belongs to the 5'-nucleotidase family
CYA_0973	COG4399	Belongs to the UPF0754 family
CYA_0976	COG0667	Aldo Keto reductase
CYA_0978	COG0745	RESPONSE REGULATOR receiver
CYA_0983	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CYA_0984	COG0583	DNA-binding transcription factor activity
CYA_0985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYA_0992	COG0371	Dehydrogenase
CYA_0996	COG1450	Type ii and iii secretion system protein
CYA_1002	COG1982	Orn Lys Arg decarboxylase major
CYA_1003	COG1253	flavin adenine dinucleotide binding
CYA_1005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CYA_1006	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CYA_1015	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYA_1026	COG0672	)-iron permease
CYA_1027	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYA_1030	COG3854	ATPases associated with a variety of cellular activities
CYA_1031	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYA_1033	COG0745	RESPONSE REGULATOR receiver
CYA_1034	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYA_1040	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CYA_1041	COG2308	Evidence 4 Homologs of previously reported genes of
CYA_1048	COG2154	pterin-4-alpha-carbinolamine dehydratase
CYA_1049	COG1090	epimerase
CYA_1050	COG1131	(ABC) transporter
CYA_1051	COG0438	transferase activity, transferring glycosyl groups
CYA_1055	COG2226	methyltransferase
CYA_1056	COG2022	thiamine diphosphate biosynthetic process
CYA_1059	COG0737	Belongs to the 5'-nucleotidase family
CYA_1063	COG0105	UTP biosynthetic process
CYA_1064	COG1116	anion transmembrane transporter activity
CYA_1068	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CYA_1069	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CYA_1071	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CYA_1072	COG0768	penicillin binding
CYA_1074	COG1480	7TM receptor with intracellular HD hydrolase
CYA_1076	COG2091	lysine biosynthetic process via aminoadipic acid
CYA_1077	COG1316	TRANSCRIPTIONal
CYA_1079	COG0326	Molecular chaperone. Has ATPase activity
CYA_1081	COG0583	DNA-binding transcription factor activity
CYA_1082	COG3046	protein related to deoxyribodipyrimidine photolyase
CYA_1083	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CYA_1090	COG0802	atpase or kinase
CYA_1091	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CYA_1092	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CYA_1093	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYA_1094	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CYA_1094	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CYA_1095	COG2135	peptidase activity
CYA_1097	COG0366	Alpha amylase catalytic
CYA_1100	COG0460	homoserine dehydrogenase
CYA_1103	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYA_1108	COG4206	TonB-dependent receptor
CYA_1114	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CYA_1116	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CYA_1120	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CYA_1120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CYA_1122	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CYA_1123	COG0175	sulfate reduction
CYA_1125	COG0640	Transcriptional regulator
CYA_1130	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CYA_1132	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYA_1135	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CYA_1139	COG0702	epimerase
CYA_1144	COG0354	folic acid binding
CYA_1148	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CYA_1151	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CYA_1153	COG0723	plastoquinol--plastocyanin reductase activity
CYA_1154	COG0438	transferase activity, transferring glycosyl groups
CYA_1157	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CYA_1158	COG0024	Methionine aminopeptidase
CYA_1159	COG0563	adenylate kinase activity
CYA_1160	COG0201	protein transport
CYA_1161	COG0200	Binds to the 23S rRNA
CYA_1163	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CYA_1164	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CYA_1165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CYA_1166	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CYA_1167	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CYA_1168	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CYA_1169	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CYA_1170	COG0255	Belongs to the universal ribosomal protein uL29 family
CYA_1171	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CYA_1172	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CYA_1173	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CYA_1174	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CYA_1175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CYA_1176	COG0089	rRNA binding
CYA_1177	COG0088	Forms part of the polypeptide exit tunnel
CYA_1178	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CYA_1186	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CYA_1189	COG1797	cobyrinic acid a,c-diamide synthase activity
CYA_1193	COG0740	serine-type endopeptidase activity
CYA_1194	COG1850	ribulose-bisphosphate carboxylase activity
CYA_1196	COG4451	ribulose bisphosphate carboxylase, small
CYA_1197	COG1836	PFAM Integral membrane protein DUF92
CYA_1201	COG1702	phosphate starvation-inducible protein PhoH
CYA_1202	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CYA_1203	COG1011	Hydrolase
CYA_1205	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CYA_1206	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CYA_1209	COG1137	ATPase activity
CYA_1210	COG0469	pyruvate kinase activity
CYA_1213	COG0557	exoribonuclease II activity
CYA_1214	COG0745	RESPONSE REGULATOR receiver
CYA_1215	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
CYA_1216	COG0436	Aminotransferase
CYA_1217	COG1160	GTP binding
CYA_1218	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CYA_1220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CYA_1221	COG2385	sporulation resulting in formation of a cellular spore
CYA_1221	COG2247	cell wall binding repeat
CYA_1224	COG0714	Associated with various cellular activities
CYA_1226	COG1959	2 iron, 2 sulfur cluster binding
CYA_1227	COG0539	negative regulation of cytoplasmic translation
CYA_1229	COG3932	Exopolysaccharide synthesis, ExoD
CYA_1231	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CYA_1232	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CYA_1235	COG4372	Transposase
CYA_1238	COG0544	peptidyl-prolyl cis-trans isomerase activity
CYA_1240	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CYA_1242	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CYA_1243	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYA_1244	COG0346	lactoylglutathione lyase activity
CYA_1249	COG4948	Mandelate Racemase Muconate Lactonizing
CYA_1253	COG0193	aminoacyl-tRNA hydrolase activity
CYA_1256	COG0495	leucyl-tRNA aminoacylation
CYA_1257	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CYA_1258	COG0572	uridine kinase
CYA_1259	COG0363	glucosamine-6-phosphate deaminase activity
CYA_1264	COG0850	regulation of cytokinetic process
CYA_1265	COG2894	cell division
CYA_1266	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CYA_1268	COG3263	regulation of cellular component size
CYA_1269	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CYA_1271	COG0511	ligase activity, forming carbon-carbon bonds
CYA_1272	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CYA_1273	COG1214	PFAM Peptidase M22, glycoprotease
CYA_1280	COG0805	protein transport
CYA_1282	COG0765	amino acid transport
CYA_1283	COG4597	amino acid ABC transporter
CYA_1284	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYA_1285	COG1126	abc transporter atp-binding protein
CYA_1290	COG0159	tryptophan synthase activity
CYA_1294	COG0602	queuosine metabolic process
CYA_1298	COG1040	competence protein
CYA_1299	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CYA_1300	COG0049	tRNA binding
CYA_1301	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CYA_1302	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CYA_1303	COG0051	transcription antitermination factor activity, RNA binding
CYA_1305	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CYA_1308	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYA_1310	COG0805	protein transport
CYA_1318	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CYA_1319	COG1429	ligase activity, forming nitrogen-metal bonds
CYA_1324	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CYA_1327	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CYA_1331	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYA_1338	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CYA_1339	COG0697	spore germination
CYA_1340	COG0180	Tryptophanyl-tRNA synthetase
CYA_1342	COG0457	Tetratricopeptide repeat
CYA_1343	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CYA_1349	COG5002	protein histidine kinase activity
CYA_1353	COG0285	dihydrofolate synthase activity
CYA_1354	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CYA_1361	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CYA_1362	COG0492	ferredoxin-NADP+ reductase activity
CYA_1363	COG0174	glutamine synthetase
CYA_1365	COG1028	Short-chain dehydrogenase reductase Sdr
CYA_1366	COG0589	response to stress
CYA_1366	COG0475	glutathione-regulated potassium exporter activity
CYA_1368	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CYA_1369	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CYA_1370	COG0395	ABC-type sugar transport system, permease component
CYA_1371	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CYA_1372	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CYA_1383	COG0735	belongs to the Fur family
CYA_1385	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CYA_1386	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CYA_1392	COG0745	RESPONSE REGULATOR receiver
CYA_1394	COG1381	Involved in DNA repair and RecF pathway recombination
CYA_1395	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CYA_1398	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYA_1403	COG0723	plastoquinol--plastocyanin reductase activity
CYA_1404	COG0739	heme binding
CYA_1406	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CYA_1407	COG0459	protein refolding
CYA_1409	COG0516	GMP reductase activity
CYA_1411	COG3659	wide pore channel activity
CYA_1412	COG3659	wide pore channel activity
CYA_1414	COG0659	secondary active sulfate transmembrane transporter activity
CYA_1415	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CYA_1417	COG1929	Belongs to the glycerate kinase type-1 family
CYA_1419	COG0154	amidase activity
CYA_1426	COG0633	Ferredoxin
CYA_1441	COG3842	ATPase activity
CYA_1442	COG0071	Belongs to the small heat shock protein (HSP20) family
CYA_1444	COG1049	propionate catabolic process, 2-methylcitrate cycle
CYA_1445	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CYA_1446	COG0254	rRNA binding
CYA_1447	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CYA_1448	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CYA_1449	COG0101	tRNA pseudouridine synthase activity
CYA_1450	COG0203	ribosomal protein L17
CYA_1451	COG0202	RNA polymerase activity
CYA_1452	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CYA_1453	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CYA_1454	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CYA_1457	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CYA_1458	COG0673	inositol 2-dehydrogenase activity
CYA_1459	COG0730	response to heat
CYA_1460	COG1605	Chorismate mutase
CYA_1460	COG0077	Prephenate dehydratase
CYA_1462	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CYA_1463	COG0616	signal peptide processing
CYA_1466	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CYA_1467	COG0473	3-isopropylmalate dehydrogenase activity
CYA_1474	COG0717	Belongs to the dCTP deaminase family
CYA_1476	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CYA_1477	COG0667	Aldo Keto reductase
CYA_1479	COG0504	CTP synthase activity
CYA_1484	COG1007	ATP synthesis coupled electron transport
CYA_1495	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CYA_1496	COG0431	NADPH-dependent FMN reductase
CYA_1500	COG0191	fructose-bisphosphate aldolase activity
CYA_1505	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CYA_1507	COG0004	ammonium transporteR
CYA_1508	COG0347	Belongs to the P(II) protein family
CYA_1512	COG1845	cytochrome c oxidase, subunit III
CYA_1513	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CYA_1515	COG1612	heme a metabolic process
CYA_1517	COG0109	protoheme IX farnesyltransferase activity
CYA_1519	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CYA_1520	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CYA_1523	COG0187	DNA topoisomerase II activity
CYA_1523	COG1372	Participates in initiation and elongation during chromosome replication
CYA_1524	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CYA_1525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CYA_1526	COG0330	HflC and HflK could
CYA_1531	COG0739	heme binding
CYA_1533	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CYA_1535	COG0529	Catalyzes the synthesis of activated sulfate
CYA_1537	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CYA_1541	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYA_1542	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CYA_1543	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CYA_1544	COG0789	Transcriptional regulator
CYA_1547	COG0861	Integral membrane protein TerC family
CYA_1548	COG1691	(AIR) carboxylase
CYA_1550	COG1372	Participates in initiation and elongation during chromosome replication
CYA_1550	COG0305	Participates in initiation and elongation during chromosome replication
CYA_1551	COG0359	binds to the 23S rRNA
CYA_1553	COG0573	inorganic phosphate transmembrane transporter activity
CYA_1554	COG0581	inorganic phosphate transmembrane transporter activity
CYA_1555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CYA_1559	COG2046	Belongs to the sulfate adenylyltransferase family
CYA_1563	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYA_1567	COG0402	S-adenosylhomocysteine deaminase activity
CYA_1569	COG0352	thiamine-phosphate diphosphorylase activity
CYA_1570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYA_1573	COG0537	adenosine 5'-monophosphoramidase activity
CYA_1574	COG2082	Precorrin-8x methylmutase
CYA_1576	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CYA_1576	COG0426	domain, Protein
CYA_1577	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CYA_1587	COG0402	S-adenosylhomocysteine deaminase activity
CYA_1588	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CYA_1593	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYA_1594	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_1598	COG0613	PHP domain protein
CYA_1599	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CYA_1602	COG3794	PFAM blue (type 1) copper domain protein
CYA_1609	COG1122	ATPase activity
CYA_1612	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CYA_1613	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CYA_1614	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CYA_1614	COG4451	ribulose bisphosphate carboxylase, small
CYA_1619	COG0335	large ribosomal subunit rRNA binding
CYA_1620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYA_1621	COG1136	(ABC) transporter
CYA_1621	COG0577	efflux transmembrane transporter activity
CYA_1622	COG0083	homoserine kinase activity
CYA_1623	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CYA_1624	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CYA_1626	COG1122	ATPase activity
CYA_1627	COG0739	heme binding
CYA_1629	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CYA_1630	COG0713	ATP synthesis coupled electron transport
CYA_1633	COG0095	Lipoate-protein ligase
CYA_1636	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CYA_1638	COG0052	Belongs to the universal ribosomal protein uS2 family
CYA_1639	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CYA_1640	COG0402	S-adenosylhomocysteine deaminase activity
CYA_1641	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CYA_1647	COG0592	DNA-directed DNA polymerase activity
CYA_1650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CYA_1651	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CYA_1652	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CYA_1654	COG1234	tRNA 3'-trailer cleavage
CYA_1655	COG0316	Belongs to the HesB IscA family
CYA_1656	COG5002	protein histidine kinase activity
CYA_1657	COG2205	protein histidine kinase activity
CYA_1657	COG5002	protein histidine kinase activity
CYA_1657	COG0784	Response regulator, receiver
CYA_1658	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CYA_1659	COG0426	domain, Protein
CYA_1659	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CYA_1663	COG0406	alpha-ribazole phosphatase activity
CYA_1664	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CYA_1665	COG1295	ribonuclease BN
CYA_1665	COG1959	2 iron, 2 sulfur cluster binding
CYA_1666	COG0009	L-threonylcarbamoyladenylate synthase
CYA_1667	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CYA_1669	COG0523	cobalamin synthesis protein
CYA_1673	COG0519	Catalyzes the synthesis of GMP from XMP
CYA_1673	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CYA_1675	COG0357	Ribosomal RNA small subunit methyltransferase G
CYA_1677	COG0724	RNA recognition motif
CYA_1678	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYA_1679	COG1121	(ABC) transporter
CYA_1680	COG0803	Belongs to the bacterial solute-binding protein 9 family
CYA_1681	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CYA_1682	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CYA_1683	COG0628	permease
CYA_1686	COG2010	Cytochrome c
CYA_1687	COG2010	Cytochrome c
CYA_1689	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CYA_1690	COG2003	Belongs to the UPF0758 family
CYA_1691	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CYA_1693	COG2239	Acts as a magnesium transporter
CYA_1694	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CYA_1694	COG0644	oxidoreductase
CYA_1697	COG0129	dihydroxy-acid dehydratase activity
CYA_1698	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CYA_1699	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CYA_1701	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CYA_1702	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CYA_1703	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CYA_1706	COG0006	proline dipeptidase activity
CYA_1709	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CYA_1712	COG0284	orotidine-5'-phosphate decarboxylase activity
CYA_1717	COG0798	PFAM Bile acid sodium symporter
CYA_1720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYA_1722	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYA_1725	COG3118	belongs to the thioredoxin family
CYA_1727	COG0321	lipoyl(octanoyl) transferase activity
CYA_1729	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CYA_1730	COG0540	Belongs to the ATCase OTCase family
CYA_1732	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CYA_1733	COG0573	inorganic phosphate transmembrane transporter activity
CYA_1734	COG0581	inorganic phosphate transmembrane transporter activity
CYA_1735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CYA_1738	COG0701	Predicted permease
CYA_1739	COG0372	Belongs to the citrate synthase family
CYA_1740	COG3688	RNA-binding protein containing a PIN domain
CYA_1741	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYA_1745	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CYA_1747	COG0527	aspartate kinase activity
CYA_1749	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CYA_1755	COG0651	ATP synthesis coupled electron transport
CYA_1756	COG1006	Multisubunit Na H antiporter MnhC subunit
CYA_1758	COG1846	Transcriptional regulator
CYA_1763	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CYA_1764	COG1271	oxidase subunit
CYA_1766	COG1294	oxidase, subunit
CYA_1767	COG0668	transmembrane transport
CYA_1768	COG0456	acetyltransferase
CYA_1770	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CYA_1775	COG0336	Belongs to the RNA methyltransferase TrmD family
CYA_1777	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CYA_1778	COG0250	Participates in transcription elongation, termination and antitermination
CYA_1779	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CYA_1780	COG0081	regulation of translation
CYA_1782	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CYA_1784	COG0222	ribosome binding
CYA_1785	COG0706	membrane insertase activity
CYA_1788	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYA_1795	COG0793	Belongs to the peptidase S41A family
CYA_1796	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CYA_1797	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CYA_1798	COG0473	3-isopropylmalate dehydrogenase activity
CYA_1803	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CYA_1806	COG0484	heat shock protein binding
CYA_1810	COG1615	UPF0182 protein
CYA_1812	COG2255	four-way junction helicase activity
CYA_1814	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYA_1814	COG0237	dephospho-CoA kinase activity
CYA_1820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYA_1824	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CYA_1827	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
CYA_1828	COG1433	Dinitrogenase iron-molybdenum cofactor
CYA_1828	COG0535	radical SAM domain protein
CYA_1831	COG0783	Belongs to the Dps family
CYA_1835	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CYA_1844	COG3585	molybdate ion transport
CYA_1845	COG0725	ABC transporter, periplasmic molybdate-binding protein
CYA_1848	COG1615	UPF0182 protein
CYA_1850	COG2255	four-way junction helicase activity
CYA_1851	COG0237	dephospho-CoA kinase activity
CYA_1851	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYA_1855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CYA_1857	COG1233	COG1233 Phytoene dehydrogenase and related
CYA_1858	COG1176	ABC-type spermidine putrescine transport system, permease component I
CYA_1859	COG3842	ATPase activity
CYA_1862	COG0233	cytoplasmic translational termination
CYA_1863	COG0617	tRNA 3'-terminal CCA addition
CYA_1864	COG4783	chaperone-mediated protein folding
CYA_1866	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CYA_1867	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CYA_1875	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CYA_1876	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CYA_1877	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYA_1879	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYA_1881	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CYA_1882	COG1357	PFAM Pentapeptide repeats (8 copies)
CYA_1882	COG0515	serine threonine protein kinase
CYA_1885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYA_1892	COG0745	RESPONSE REGULATOR receiver
CYA_1895	COG0739	heme binding
CYA_1896	COG0215	cysteine-tRNA ligase activity
CYA_1899	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CYA_1903	COG1957	nucleoside hydrolase
CYA_1904	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CYA_1905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CYA_1906	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CYA_1908	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CYA_1915	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_1917	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CYA_1918	COG1335	isochorismatase
CYA_1921	COG0411	ABC transporter
CYA_1923	COG0559	Belongs to the binding-protein-dependent transport system permease family
CYA_1926	COG1196	nuclear chromosome segregation
CYA_1926	COG0741	lytic transglycosylase activity
CYA_1926	COG0739	heme binding
CYA_1929	COG0484	heat shock protein binding
CYA_1936	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CYA_1942	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CYA_1944	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CYA_1945	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CYA_1947	COG1070	Carbohydrate kinase
CYA_1948	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYA_1955	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CYA_1957	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CYA_1960	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYA_1963	COG4948	Mandelate Racemase Muconate Lactonizing
CYA_1965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CYA_1969	COG0033	Phosphoglucomutase
CYA_1974	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CYA_1975	COG1722	exodeoxyribonuclease VII activity
CYA_1976	COG1570	exodeoxyribonuclease VII activity
CYA_1981	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CYA_1982	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CYA_1988	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CYA_1994	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_1995	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_1996	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_2009	COG3956	TIGRFAM MazG family protein
CYA_2013	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CYA_2015	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CYA_2018	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CYA_2021	COG0606	chelatase, subunit chli
CYA_2022	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CYA_2027	COG0745	RESPONSE REGULATOR receiver
CYA_2032	COG1120	ATPase activity
CYA_2033	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYA_2035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CYA_2037	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYA_2038	COG0728	peptidoglycan biosynthetic process
CYA_2040	COG1413	lyase activity
CYA_2045	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CYA_2048	COG1136	(ABC) transporter
CYA_2049	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CYA_2051	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CYA_2052	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CYA_2055	COG0484	heat shock protein binding
CYA_2057	COG2234	aminopeptidase activity
CYA_2058	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CYA_2059	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYA_2061	COG0312	modulator of DNA gyrase
CYA_2062	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CYA_2065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYA_2067	COG3781	membrane
CYA_2071	COG0297	glycogen (starch) synthase activity
CYA_2072	COG1543	Belongs to the glycosyl hydrolase 57 family
CYA_2073	COG0028	Belongs to the TPP enzyme family
CYA_2083	COG0659	secondary active sulfate transmembrane transporter activity
CYA_2087	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CYA_2088	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CYA_2096	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CYA_2097	COG1555	photosystem II stabilization
CYA_2098	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CYA_2098	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CYA_2104	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CYA_2107	COG2226	methyltransferase
CYA_2109	COG1840	ABC-type Fe3 transport system, periplasmic component
CYA_2111	COG1178	ABC-type Fe3 transport system permease component
CYA_2112	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CYA_2113	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CYA_2114	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYA_2115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CYA_2117	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYA_2119	COG0356	it plays a direct role in the translocation of protons across the membrane
CYA_2123	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CYA_2125	COG0783	Belongs to the Dps family
CYA_2126	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CYA_2130	COG0440	acetolactate synthase activity
CYA_2134	COG0837	glucose binding
CYA_2136	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CYA_2138	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYA_2141	COG2211	Major facilitator Superfamily
CYA_2142	COG1027	Aspartate ammonia-lyase
CYA_2144	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CYA_2145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CYA_2146	COG0515	serine threonine protein kinase
CYA_2146	COG2815	serine threonine protein kinase
CYA_2147	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CYA_2150	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CYA_2152	COG0825	malonyl-CoA metabolic process
CYA_2155	COG0643	Histidine kinase
CYA_2155	COG0643	Histidine kinase
CYA_2155	COG2198	Histidine kinase
CYA_2155	COG2198	Histidine kinase
CYA_2156	COG0840	transmembrane signaling receptor activity
CYA_2156	COG2203	Gaf domain
CYA_2162	COG0784	Response regulator, receiver
CYA_2170	COG0517	IMP dehydrogenase activity
CYA_2170	COG1994	Peptidase M50
CYA_2171	COG0612	Peptidase, M16
CYA_2174	COG0454	-acetyltransferase
CYA_2177	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CYA_2180	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CYA_2181	COG0860	N-Acetylmuramoyl-L-alanine amidase
CYA_2186	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CYA_2190	COG0719	Fe-S assembly protein
CYA_2192	COG1970	mechanosensitive ion channel activity
CYA_2193	COG0396	ATPase activity
CYA_2194	COG0719	Fe-S assembly protein
CYA_2199	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CYA_2201	COG0066	3-isopropylmalate dehydratase activity
CYA_2206	COG0469	pyruvate kinase activity
CYA_2214	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CYA_2216	COG0189	ligase activity
CYA_2218	COG1185	polyribonucleotide nucleotidyltransferase activity
CYA_2224	COG1131	(ABC) transporter
CYA_2229	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYA_2231	COG0517	IMP dehydrogenase activity
CYA_2231	COG1125	glycine betaine transport
CYA_2233	COG1191	sigma factor activity
CYA_2235	COG2720	vancomycin resistance protein
CYA_2243	COG1881	PFAM PEBP family protein
CYA_2247	COG0312	modulator of DNA gyrase
CYA_2252	COG0312	modulator of DNA gyrase
CYA_2253	COG1573	uracil-dna glycosylase
CYA_2254	COG2226	methyltransferase
CYA_2257	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYA_2258	COG0393	Putative heavy-metal-binding
CYA_2259	COG0217	transcriptional regulatory protein
CYA_2262	COG0515	serine threonine protein kinase
CYA_2264	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CYA_2272	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CYA_2276	COG0142	geranyltranstransferase activity
CYA_2277	COG1937	Protein conserved in bacteria
CYA_2279	COG0228	four-way junction DNA binding
CYA_2282	COG0107	imidazoleglycerol-phosphate synthase activity
CYA_2283	COG1218	3'(2'),5'-bisphosphate nucleotidase
CYA_2285	COG1842	Phage shock protein A
CYA_2291	COG1331	Highly conserved protein containing a thioredoxin domain
CYA_2292	COG0456	acetyltransferase
CYA_2296	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CYA_2297	COG0275	rRNA processing
CYA_2298	COG2197	response regulator
CYA_2304	COG2133	pyrroloquinoline quinone binding
CYA_2316	COG0745	RESPONSE REGULATOR receiver
CYA_2323	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYA_2324	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CYA_2325	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CYA_2326	COG0022	dehydrogenase e1 component
CYA_2326	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYA_2328	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYA_2329	COG0358	DNA primase activity
CYA_2333	COG1357	PFAM Pentapeptide repeats (8 copies)
CYA_2333	COG0515	serine threonine protein kinase
CYA_2334	COG2372	response to copper ion
CYA_2336	COG3437	response regulator, receiver
CYA_2338	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CYA_2339	COG0442	prolyl-tRNA aminoacylation
CYA_2346	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CYA_2347	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CYA_2352	COG5002	protein histidine kinase activity
CYA_2353	COG4221	oxidoreductase activity
CYA_2356	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CYA_2362	COG0601	transmembrane transport
CYA_2365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CYA_2366	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CYA_2367	COG0416	fatty acid biosynthetic process
CYA_2369	COG0134	indole-3-glycerol-phosphate synthase activity
CYA_2372	COG2217	Heavy metal translocating P-type atpase
CYA_2373	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
CYA_2376	COG0009	L-threonylcarbamoyladenylate synthase
CYA_2378	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CYA_2379	COG0539	negative regulation of cytoplasmic translation
CYA_2382	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CYA_2385	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CYA_2386	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CYA_2387	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CYA_2389	COG0629	single-stranded DNA binding
CYA_2390	COG2099	Precorrin-6x reductase
CYA_2391	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYA_2395	COG1304	FMN binding
CYA_2407	COG0196	riboflavin kinase activity
CYA_2408	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CYA_2410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYA_2411	COG0646	methionine synthase
CYA_2411	COG1410	methionine synthase
CYA_2412	COG1177	transmembrane transport
CYA_2413	COG2267	carboxylic ester hydrolase activity
CYA_2417	COG0583	DNA-binding transcription factor activity
CYA_2419	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CYA_2420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CYA_2421	COG0528	UMP kinase activity
CYA_2423	COG2119	membrane
CYA_2432	COG0248	Ppx GppA phosphatase
CYA_2433	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CYA_2436	COG1640	4-alpha-glucanotransferase
CYA_2438	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CYA_2441	COG1846	Transcriptional regulator
CYA_2445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CYA_2446	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CYA_2454	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CYA_2456	COG1575	Belongs to the MenA family. Type 1 subfamily
CYA_2460	COG0436	Aminotransferase
CYA_2461	COG0673	inositol 2-dehydrogenase activity
CYA_2464	COG0783	Belongs to the Dps family
CYA_2466	COG0463	Glycosyl transferase, family 2
CYA_2467	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CYA_2473	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CYA_2473	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CYA_2474	COG1725	Transcriptional regulator
CYA_2477	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CYA_2479	COG0559	Belongs to the binding-protein-dependent transport system permease family
CYA_2481	COG3119	arylsulfatase activity
CYA_2483	COG1028	Short-chain dehydrogenase reductase Sdr
CYA_2484	COG0405	Gamma-glutamyltransferase
CYA_2485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CYA_2489	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CYA_2495	COG0124	histidyl-tRNA synthetase
CYA_2501	COG0662	Cupin 2, conserved barrel domain protein
CYA_2501	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CYA_2507	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CYA_2510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYA_2512	COG0758	DNA mediated transformation
CYA_2512	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CYA_2513	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CYA_2514	COG1473	amidohydrolase
CYA_2519	COG0419	ATPase involved in DNA repair
CYA_2521	COG2885	chlorophyll binding
CYA_2522	COG2885	chlorophyll binding
CYA_2527	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CYA_2529	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYA_2531	COG1121	(ABC) transporter
CYA_2532	COG3443	Belongs to the bacterial solute-binding protein 9 family
CYA_2532	COG0803	Belongs to the bacterial solute-binding protein 9 family
CYA_2533	COG2166	iron-sulfur cluster assembly
CYA_2534	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CYA_2538	COG3751	2OG-Fe(II) oxygenase superfamily
CYA_2553	COG5002	protein histidine kinase activity
CYA_2554	COG0148	phosphopyruvate hydratase activity
CYA_2555	COG1505	serine-type exopeptidase activity
CYA_2556	COG0589	response to stress
CYA_2557	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
CYA_2563	COG3264	Mechanosensitive ion channel
CYA_2563	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CYA_2564	COG0556	nucleotide-excision repair
CYA_2566	COG0523	cobalamin synthesis protein
CYA_2569	COG5002	protein histidine kinase activity
CYA_2570	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CYA_2579	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CYA_2582	COG1193	negative regulation of DNA recombination
CYA_2585	COG0832	Belongs to the urease beta subunit family
CYA_2590	COG1420	regulation of RNA biosynthetic process
CYA_2591	COG0037	tRNA processing
CYA_2592	COG2385	sporulation resulting in formation of a cellular spore
CYA_2594	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CYA_2595	COG0251	oxidation-reduction process
CYA_2601	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
CYA_2603	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CYA_2605	COG0716	FMN binding
CYA_2608	COG3487	Iron-regulated protein
CYA_2611	COG3128	pkhd-type hydroxylase
CYA_2613	COG0398	Pfam SNARE associated Golgi protein
CYA_2614	COG4106	trans-aconitate 2-methyltransferase activity
CYA_2617	COG4243	Vitamin k epoxide reductase
CYA_2618	COG3706	GGDEF domain
CYA_2618	COG0745	RESPONSE REGULATOR receiver
CYA_2619	COG0434	BtpA family
CYA_2620	COG0167	dihydroorotate dehydrogenase activity
CYA_2624	COG0497	DNA recombination
CYA_2626	COG0131	Imidazoleglycerol-phosphate dehydratase
CYA_2628	COG0514	ATP-dependent DNA helicase (RecQ)
CYA_2629	COG1472	Belongs to the glycosyl hydrolase 3 family
CYA_2630	COG2010	Cytochrome c
CYA_2631	COG0170	dolichyl monophosphate biosynthetic process
CYA_2635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYA_2642	COG2211	Major facilitator Superfamily
CYA_2643	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CYA_2645	COG0307	riboflavin synthase, alpha
CYA_2646	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CYA_2648	COG0297	glycogen (starch) synthase activity
CYA_2654	COG0512	Glutamine amidotransferase of anthranilate synthase
CYA_2654	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYA_2658	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CYA_2659	COG5002	protein histidine kinase activity
CYA_2663	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CYA_2663	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CYA_2666	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CYA_2670	COG0039	L-malate dehydrogenase activity
CYA_2671	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CYA_2675	COG0483	inositol monophosphate 1-phosphatase activity
CYA_2678	COG1492	cobalamin metabolic process
CYA_2679	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CYA_2680	COG1324	tolerance protein
CYA_2681	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CYA_2683	COG0003	Pfam Anion-transporting ATPase
CYA_2686	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CYA_2688	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CYA_2696	COG2052	Domain of unknown function (DUF370)
CYA_2697	COG0194	GDP metabolic process
CYA_2703	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CYA_2704	COG0069	glutamate synthase activity
CYA_2704	COG0067	glutamate synthase
CYA_2704	COG0070	glutamate synthase
CYA_2713	COG2226	methyltransferase
CYA_2713	COG0596	Alpha beta hydrolase
CYA_2713	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CYA_2715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYA_2727	COG0745	RESPONSE REGULATOR receiver
CYA_2729	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CYA_2732	COG0018	arginyl-trna synthetase
CYA_2734	COG2086	electron transfer activity
CYA_2735	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CYA_2736	COG0762	integral membrane protein
CYA_2741	COG0840	transmembrane signaling receptor activity
CYA_2741	COG2203	Gaf domain
CYA_2742	COG2198	Histidine kinase
CYA_2742	COG0643	Histidine kinase
CYA_2742	COG2198	Histidine kinase
CYA_2742	COG0643	Histidine kinase
CYA_2744	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CYA_2748	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CYA_2751	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYA_2753	COG2385	sporulation resulting in formation of a cellular spore
CYA_2755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYA_2759	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CYA_2760	COG1090	epimerase
CYA_2762	COG0113	porphobilinogen synthase activity
CYA_2769	COG0483	inositol monophosphate 1-phosphatase activity
CYA_2773	COG2205	protein histidine kinase activity
CYA_2779	COG5001	Diguanylate cyclase
CYA_2779	COG4251	negative regulation of phosphorylation
CYA_2779	COG3706	GGDEF domain
CYA_2779	COG2203	Gaf domain
CYA_2780	COG0084	hydrolase, TatD family'
CYA_2782	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CYA_2783	COG3833	ABC-type maltose transport systems, permease component
CYA_2786	COG1175	transmembrane transport
CYA_2788	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CYA_2792	COG0302	gtp cyclohydrolase
CYA_2793	COG0300	oxidoreductase activity
CYA_2796	COG2890	protein-(glutamine-N5) methyltransferase activity
CYA_2797	COG3852	Histidine kinase
CYA_2801	COG3118	belongs to the thioredoxin family
CYA_2803	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYA_2808	COG0277	FAD linked oxidase domain protein
CYA_2809	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYA_2810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYA_2811	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CYA_2812	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CYA_2813	COG0138	bifunctional purine biosynthesis protein purh
CYA_2815	COG0811	peptide transport
CYA_2816	COG0848	biopolymer transport protein
CYA_2817	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CYA_2818	COG0793	Belongs to the peptidase S41A family
CYA_2820	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CYA_2822	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CYA_2822	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CYA_2826	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CYA_2826	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CYA_2828	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CYA_2830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CYA_2834	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYA_2841	COG0343	queuine tRNA-ribosyltransferase activity
CYA_2849	COG0450	alkyl hydroperoxide reductase
CYA_2851	COG0668	transmembrane transport
CYA_2856	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CYA_2859	COG0515	serine threonine protein kinase
CYA_2861	COG0475	glutathione-regulated potassium exporter activity
CYA_2861	COG0589	response to stress
CYA_2862	COG0751	glycine-tRNA ligase activity
CYA_2866	COG2205	protein histidine kinase activity
CYA_2871	COG2217	Heavy metal translocating P-type atpase
CYA_2873	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CYA_2874	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYA_2875	COG0360	Binds together with S18 to 16S ribosomal RNA
CYA_2876	COG0629	single-stranded DNA binding
CYA_2877	COG2866	Carboxypeptidase
CYA_2878	COG0589	response to stress
CYA_2882	COG1131	(ABC) transporter
CYA_2883	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CYA_2884	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CYA_2886	COG5002	protein histidine kinase activity
CYA_2886	COG5001	Diguanylate cyclase
CYA_2886	COG3447	MASE1 domain protein
CYA_2887	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CYA_2888	COG1129	ABC transporter
CYA_2890	COG0772	Belongs to the SEDS family
CYA_2891	COG1104	cysteine desulfurase activity
CYA_2894	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CYA_2895	COG0019	diaminopimelate decarboxylase activity
CYA_2897	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYA_2899	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CYA_2903	COG1196	nuclear chromosome segregation
CYA_2904	COG0594	ribonuclease P activity
CYA_2905	COG0230	Belongs to the bacterial ribosomal protein bL34 family