locus-tag	class	description
KR49_00190	COG2135	peptidase activity
KR49_00195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KR49_00200	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KR49_00205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KR49_00235	COG0251	oxidation-reduction process
KR49_00245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KR49_00250	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KR49_00255	COG1132	(ABC) transporter
KR49_00260	COG0456	acetyltransferase
KR49_00275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KR49_00280	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KR49_00300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KR49_00305	COG0811	peptide transport
KR49_00335	COG1845	cytochrome c oxidase, subunit III
KR49_00340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KR49_00360	COG0530	calcium, potassium:sodium antiporter activity
KR49_00365	COG0659	secondary active sulfate transmembrane transporter activity
KR49_00370	COG0418	dihydroorotase activity
KR49_00395	COG0159	tryptophan synthase activity
KR49_00445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR49_00465	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KR49_00465	COG0140	phosphoribosyl-ATP diphosphatase activity
KR49_00480	COG0542	response to heat
KR49_00505	COG3794	PFAM blue (type 1) copper domain protein
KR49_00515	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KR49_00520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KR49_00555	COG1940	carbohydrate kinase activity
KR49_00560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KR49_00575	COG0339	signal peptide processing
KR49_00580	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR49_00585	COG0083	homoserine kinase activity
KR49_00590	COG0837	glucose binding
KR49_00600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KR49_00615	COG0180	Tryptophanyl-tRNA synthetase
KR49_00630	COG1230	cation diffusion facilitator family transporter
KR49_00825	COG2124	cytochrome p450
KR49_00855	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KR49_00960	COG4638	Rieske (2fe-2S)
KR49_00965	COG1116	anion transmembrane transporter activity
KR49_00970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KR49_00985	COG0375	protein maturation
KR49_00990	COG0010	Belongs to the arginase family
KR49_01055	COG2072	flavoprotein involved in K transport
KR49_01080	COG2144	transferase activity, transferring acyl groups
KR49_01105	COG0405	Gamma-glutamyltransferase
KR49_01130	COG1487	ribonuclease activity
KR49_01155	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KR49_01160	COG1611	Belongs to the LOG family
KR49_01180	COG2234	aminopeptidase activity
KR49_01190	COG2304	oxidoreductase activity
KR49_01205	COG1322	Protein conserved in bacteria
KR49_01210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KR49_01290	COG0189	ligase activity
KR49_01290	COG4067	protein conserved in archaea
KR49_01310	COG2197	response regulator
KR49_01360	COG0724	RNA recognition motif
KR49_01470	COG2197	response regulator
KR49_01485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KR49_01490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KR49_01505	COG1121	(ABC) transporter
KR49_01535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KR49_01545	COG1119	ATPase activity
KR49_01605	COG2226	methyltransferase
KR49_01650	COG2059	Chromate
KR49_01655	COG1201	RNA secondary structure unwinding
KR49_01665	COG1793	dna ligase
KR49_01740	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KR49_01750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KR49_01770	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KR49_01795	COG0740	serine-type endopeptidase activity
KR49_01805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KR49_01810	COG1136	(ABC) transporter
KR49_01810	COG0577	efflux transmembrane transporter activity
KR49_01815	COG0469	pyruvate kinase activity
KR49_01840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KR49_01845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KR49_01875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KR49_01885	COG3842	ATPase activity
KR49_01890	COG0395	ABC-type sugar transport system, permease component
KR49_01895	COG1175	transmembrane transport
KR49_01900	COG1653	transport
KR49_01905	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KR49_01910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KR49_01915	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KR49_01920	COG0326	Molecular chaperone. Has ATPase activity
KR49_01935	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KR49_01940	COG0483	inositol monophosphate 1-phosphatase activity
KR49_01945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KR49_01955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KR49_01960	COG0581	inorganic phosphate transmembrane transporter activity
KR49_01965	COG0573	inorganic phosphate transmembrane transporter activity
KR49_01970	COG0443	Heat shock 70 kDa protein
KR49_01975	COG0484	heat shock protein binding
KR49_01985	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KR49_01990	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KR49_01995	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KR49_02000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KR49_02000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KR49_02005	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KR49_02010	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KR49_02035	COG0166	Belongs to the GPI family
KR49_02040	COG0495	leucyl-tRNA aminoacylation
KR49_02050	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KR49_02055	COG1104	cysteine desulfurase activity
KR49_02070	COG2027	D-alanyl-D-alanine carboxypeptidase
KR49_02080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KR49_02090	COG0322	excinuclease ABC activity
KR49_02100	COG3046	protein related to deoxyribodipyrimidine photolyase
KR49_02110	COG0613	PHP domain protein
KR49_02125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KR49_02130	COG1410	methionine synthase
KR49_02130	COG0646	methionine synthase
KR49_02155	COG2385	sporulation resulting in formation of a cellular spore
KR49_02195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KR49_02200	COG0072	phenylalanine-tRNA ligase activity
KR49_02200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KR49_02205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KR49_02210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KR49_02215	COG0557	exoribonuclease II activity
KR49_02225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KR49_02260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KR49_02265	COG0739	heme binding
KR49_02280	COG0450	alkyl hydroperoxide reductase
KR49_02285	COG1615	UPF0182 protein
KR49_02290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KR49_02295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KR49_02310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KR49_02315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KR49_02315	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KR49_02330	COG2119	membrane
KR49_02340	COG0557	exoribonuclease II activity
KR49_02345	COG0163	prenyltransferase activity
KR49_02360	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KR49_02365	COG0312	modulator of DNA gyrase
KR49_02375	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KR49_02390	COG0861	Integral membrane protein TerC family
KR49_02460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KR49_02480	COG0793	Belongs to the peptidase S41A family
KR49_02485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KR49_02490	COG1573	uracil-dna glycosylase
KR49_02500	COG0436	Aminotransferase
KR49_02505	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
KR49_02535	COG1836	PFAM Integral membrane protein DUF92
KR49_02545	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KR49_02555	COG1129	ABC transporter
KR49_02560	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KR49_02580	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KR49_02585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KR49_02590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KR49_02690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KR49_02700	COG0129	dihydroxy-acid dehydratase activity
KR49_02715	COG0363	glucosamine-6-phosphate deaminase activity
KR49_02720	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KR49_02725	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KR49_02730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KR49_02735	COG1494	fructose-1,6-bisphosphatase
KR49_02740	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KR49_02750	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KR49_02780	COG0826	peptidase U32
KR49_02790	COG0644	oxidoreductase
KR49_02800	COG0751	glycine-tRNA ligase activity
KR49_02805	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KR49_02810	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
KR49_02815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KR49_02825	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KR49_02830	COG0052	Belongs to the universal ribosomal protein uS2 family
KR49_02835	COG1216	Glycosyl transferase, family 2
KR49_02885	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KR49_02890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KR49_02910	COG0590	tRNA wobble adenosine to inosine editing
KR49_02910	COG0037	tRNA processing
KR49_02915	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KR49_02925	COG0174	glutamine synthetase
KR49_02930	COG2226	methyltransferase
KR49_02955	COG0515	serine threonine protein kinase
KR49_02960	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
KR49_02970	COG0628	permease
KR49_02975	COG0628	permease
KR49_02990	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KR49_02995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KR49_03000	COG0508	dehydrogenase complex catalyzes the overall conversion of
KR49_03000	COG0022	dehydrogenase e1 component
KR49_03015	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KR49_03020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KR49_03025	COG0792	nuclease activity
KR49_03040	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KR49_03065	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KR49_03085	COG0798	PFAM Bile acid sodium symporter
KR49_03095	COG0358	DNA primase activity
KR49_03110	COG0632	four-way junction helicase activity
KR49_03115	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KR49_03125	COG0587	DNA-directed DNA polymerase activity
KR49_03130	COG0154	amidase activity
KR49_03140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KR49_03145	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KR49_03155	COG0505	Belongs to the CarA family
KR49_03160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KR49_03170	COG1132	(ABC) transporter
KR49_03180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KR49_03200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KR49_03215	COG2176	DNA-directed DNA polymerase activity
KR49_03220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KR49_03230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KR49_03235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KR49_03240	COG0142	geranyltranstransferase activity
KR49_03245	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KR49_03250	COG0860	N-Acetylmuramoyl-L-alanine amidase
KR49_03255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KR49_03260	COG2045	Belongs to the ComB family
KR49_03265	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KR49_03270	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KR49_03280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KR49_03285	COG1597	lipid kinase activity
KR49_03285	COG1803	Methylglyoxal synthase
KR49_03295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KR49_03305	COG0297	glycogen (starch) synthase activity
KR49_03310	COG1376	ErfK ybiS ycfS ynhG family protein
KR49_03315	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KR49_03320	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KR49_03325	COG0681	Belongs to the peptidase S26 family
KR49_03410	COG0701	Predicted permease
KR49_03435	COG1121	(ABC) transporter
KR49_03460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KR49_03480	COG1640	4-alpha-glucanotransferase
KR49_03490	COG1187	pseudouridine synthase activity
KR49_03495	COG5002	protein histidine kinase activity
KR49_03500	COG0745	RESPONSE REGULATOR receiver
KR49_03510	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KR49_03515	COG1982	Orn Lys Arg decarboxylase major
KR49_03520	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KR49_03525	COG0575	Belongs to the CDS family
KR49_03535	COG0596	Alpha beta hydrolase
KR49_03540	COG0371	Dehydrogenase
KR49_03545	COG0542	response to heat
KR49_03550	COG0456	acetyltransferase
KR49_03555	COG0019	diaminopimelate decarboxylase activity
KR49_03560	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KR49_03565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KR49_03570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KR49_03585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KR49_03615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KR49_03640	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KR49_03655	COG0475	glutathione-regulated potassium exporter activity
KR49_03655	COG0589	response to stress
KR49_03660	COG1132	(ABC) transporter
KR49_03665	COG0724	RNA recognition motif
KR49_03680	COG0513	Belongs to the DEAD box helicase family
KR49_03720	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KR49_03740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KR49_03755	COG0271	Belongs to the BolA IbaG family
KR49_03760	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KR49_03770	COG0745	RESPONSE REGULATOR receiver
KR49_03785	COG1233	COG1233 Phytoene dehydrogenase and related
KR49_03795	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KR49_03990	COG0123	including yeast histone deacetylase and acetoin utilization protein
KR49_04030	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KR49_04040	COG0735	belongs to the Fur family
KR49_04055	COG1799	cell septum assembly
KR49_04115	COG2873	o-acetylhomoserine
KR49_04120	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KR49_04150	COG1126	abc transporter atp-binding protein
KR49_04155	COG0765	amino acid transport
KR49_04160	COG4597	amino acid ABC transporter
KR49_04165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KR49_04180	COG0659	secondary active sulfate transmembrane transporter activity
KR49_04220	COG0799	negative regulation of ribosome biogenesis
KR49_04230	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KR49_04245	COG1115	amino acid carrier protein
KR49_04255	COG1132	(ABC) transporter
KR49_04260	COG2501	S4 domain
KR49_04265	COG0149	triose-phosphate isomerase activity
KR49_04270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KR49_04280	COG1429	ligase activity, forming nitrogen-metal bonds
KR49_04285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KR49_04295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KR49_04300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KR49_04310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KR49_04340	COG0745	RESPONSE REGULATOR receiver
KR49_04350	COG2326	polyphosphate kinase activity
KR49_04385	COG0640	Transcriptional regulator
KR49_04395	COG0668	transmembrane transport
KR49_04410	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KR49_04415	COG0047	phosphoribosylformylglycinamidine synthase activity
KR49_04420	COG1619	proteins homologs of microcin C7 resistance protein MccF
KR49_04435	COG0191	fructose-bisphosphate aldolase activity
KR49_04440	COG0673	inositol 2-dehydrogenase activity
KR49_04450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KR49_04455	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KR49_04465	COG3954	Phosphoribulokinase
KR49_04470	COG0473	3-isopropylmalate dehydrogenase activity
KR49_04475	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KR49_04480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KR49_04495	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KR49_04510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KR49_04515	COG2197	response regulator
KR49_04525	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KR49_04540	COG0517	IMP dehydrogenase activity
KR49_04550	COG1376	ErfK ybiS ycfS ynhG family protein
KR49_04680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KR49_04690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KR49_04720	COG0308	aminopeptidase N
KR49_04740	COG2205	protein histidine kinase activity
KR49_04755	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KR49_04760	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KR49_04770	COG1797	cobyrinic acid a,c-diamide synthase activity
KR49_04775	COG1254	Belongs to the acylphosphatase family
KR49_04790	COG0406	alpha-ribazole phosphatase activity
KR49_04805	COG0142	geranyltranstransferase activity
KR49_04815	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KR49_04820	COG1480	7TM receptor with intracellular HD hydrolase
KR49_04830	COG0564	pseudouridine synthase activity
KR49_04840	COG0011	TIGRFAM Protein of
KR49_04870	COG0395	ABC-type sugar transport system, permease component
KR49_04875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KR49_04880	COG1543	Belongs to the glycosyl hydrolase 57 family
KR49_04885	COG0644	oxidoreductase
KR49_04890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KR49_04900	COG0516	GMP reductase activity
KR49_04905	COG3118	belongs to the thioredoxin family
KR49_04910	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KR49_04920	COG2010	Cytochrome c
KR49_04940	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
KR49_04945	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KR49_04980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KR49_04990	COG2166	iron-sulfur cluster assembly
KR49_04995	COG0460	homoserine dehydrogenase
KR49_05030	COG0012	GTP binding
KR49_05040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KR49_05040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KR49_05045	COG0215	cysteine-tRNA ligase activity
KR49_05055	COG0733	neurotransmitter:sodium symporter activity
KR49_05060	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KR49_05080	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
KR49_05090	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KR49_05115	COG0492	ferredoxin-NADP+ reductase activity
KR49_05120	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KR49_05135	COG2226	methyltransferase
KR49_05160	COG2267	carboxylic ester hydrolase activity
KR49_05165	COG0440	acetolactate synthase activity
KR49_05170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KR49_05190	COG0626	cystathionine gamma-synthase activity
KR49_05200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KR49_05205	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KR49_05220	COG1022	Amp-dependent synthetase and ligase
KR49_05225	COG0321	lipoyl(octanoyl) transferase activity
KR49_05230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KR49_05235	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KR49_05240	COG1381	Involved in DNA repair and RecF pathway recombination
KR49_05250	COG0438	transferase activity, transferring glycosyl groups
KR49_05255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KR49_05260	COG1799	cell septum assembly
KR49_05265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KR49_05275	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KR49_05280	COG1160	GTP binding
KR49_05295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KR49_05310	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KR49_05405	COG0114	fumarate hydratase activity
KR49_05410	COG4581	dead DEAH box helicase
KR49_05425	COG0385	Bile acid
KR49_05430	COG0156	8-amino-7-oxononanoate synthase activity
KR49_05445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KR49_05460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KR49_05475	COG0357	Ribosomal RNA small subunit methyltransferase G
KR49_05515	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KR49_05525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KR49_05530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KR49_05535	COG0085	RNA polymerase activity
KR49_05540	COG0084	hydrolase, TatD family'
KR49_05545	COG0268	Binds directly to 16S ribosomal RNA
KR49_05550	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KR49_05555	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KR49_05560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KR49_05575	COG0641	radical SAM
KR49_05590	COG0779	Required for maturation of 30S ribosomal subunits
KR49_05595	COG0195	Participates in both transcription termination and antitermination
KR49_05605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KR49_05670	COG1053	succinate dehydrogenase
KR49_05705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KR49_05710	COG0776	regulation of translation
KR49_05780	COG2211	Major facilitator Superfamily
KR49_05785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KR49_05835	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KR49_05880	COG0284	orotidine-5'-phosphate decarboxylase activity
KR49_05890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KR49_05900	COG2197	response regulator
KR49_05930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KR49_05945	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KR49_05950	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KR49_05955	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KR49_05960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KR49_05975	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KR49_05985	COG0151	Belongs to the GarS family
KR49_05990	COG5002	protein histidine kinase activity
KR49_05995	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KR49_06000	COG4251	negative regulation of phosphorylation
KR49_06010	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KR49_06015	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KR49_06020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KR49_06025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KR49_06030	COG0217	transcriptional regulatory protein
KR49_06050	COG0363	glucosamine-6-phosphate deaminase activity
KR49_06055	COG2385	sporulation resulting in formation of a cellular spore
KR49_06055	COG2247	cell wall binding repeat
KR49_06060	COG1234	tRNA 3'-trailer cleavage
KR49_06065	COG2010	Cytochrome c
KR49_06080	COG2264	protein methyltransferase activity
KR49_06085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KR49_06105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KR49_06140	COG0443	Heat shock 70 kDa protein
KR49_06155	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KR49_06160	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KR49_06175	COG0459	protein refolding
KR49_06180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KR49_06185	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KR49_06190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KR49_06205	COG0387	Pfam Sodium calcium exchanger
KR49_06210	COG0006	proline dipeptidase activity
KR49_06215	COG1253	flavin adenine dinucleotide binding
KR49_06220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KR49_06225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KR49_06230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KR49_06230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KR49_06240	COG3012	SEC-C Motif Domain Protein
KR49_06245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KR49_06255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KR49_06265	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KR49_06270	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KR49_06275	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KR49_06280	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KR49_06290	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KR49_06295	COG0356	it plays a direct role in the translocation of protons across the membrane
KR49_06305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KR49_06310	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KR49_06345	COG0772	Belongs to the SEDS family
KR49_06355	COG1333	cytochrome c biogenesis protein
KR49_06360	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KR49_06390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KR49_06415	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KR49_06460	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KR49_06470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KR49_06475	COG1596	polysaccharide export
KR49_06480	COG0489	protein tyrosine kinase activity
KR49_06550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KR49_06565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KR49_06575	COG3562	capsule polysaccharide
KR49_06605	COG2089	acid synthase
KR49_06730	COG0116	Belongs to the methyltransferase superfamily
KR49_06755	COG1196	nuclear chromosome segregation
KR49_06770	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KR49_06775	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KR49_06785	COG0439	Biotin carboxylase
KR49_06800	COG0515	serine threonine protein kinase
KR49_06820	COG4178	(ABC) transporter
KR49_06825	COG0537	adenosine 5'-monophosphoramidase activity
KR49_06930	COG0242	peptide deformylase activity
KR49_06940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KR49_06945	COG0719	Fe-S assembly protein
KR49_06950	COG0396	ATPase activity
KR49_06955	COG0719	Fe-S assembly protein
KR49_06960	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
KR49_06980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KR49_07020	COG0033	Phosphoglucomutase
KR49_07030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KR49_07040	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KR49_07055	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KR49_07060	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KR49_07065	COG0175	sulfate reduction
KR49_07070	COG1252	NADH dehydrogenase
KR49_07075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KR49_07080	COG3273	potassium ion transport
KR49_07080	COG0471	metal ion transport
KR49_07085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KR49_07090	COG0569	domain protein
KR49_07095	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KR49_07120	COG0488	(ABC) transporter
KR49_07130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KR49_07150	COG1643	Atp-dependent helicase
KR49_07155	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KR49_07165	COG1570	exodeoxyribonuclease VII activity
KR49_07170	COG1722	exodeoxyribonuclease VII activity
KR49_07215	COG0483	inositol monophosphate 1-phosphatase activity
KR49_07230	COG1968	undecaprenyl-diphosphatase activity
KR49_07240	COG1555	photosystem II stabilization
KR49_07245	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KR49_07250	COG4243	Vitamin k epoxide reductase
KR49_07255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KR49_07270	COG1032	radical SAM domain protein
KR49_07300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KR49_07330	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KR49_07335	COG1472	Belongs to the glycosyl hydrolase 3 family
KR49_07340	COG0463	Glycosyl transferase, family 2
KR49_07340	COG0457	Tetratricopeptide repeat
KR49_07345	COG1587	Uroporphyrinogen-III synthase
KR49_07360	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
KR49_07370	COG0316	Belongs to the HesB IscA family
KR49_07390	COG1090	epimerase
KR49_07405	COG0484	heat shock protein binding
KR49_07410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KR49_07415	COG3659	wide pore channel activity
KR49_07420	COG3659	wide pore channel activity
KR49_07445	COG1215	transferase activity, transferring glycosyl groups
KR49_07470	COG1122	ATPase activity
KR49_07480	COG0745	RESPONSE REGULATOR receiver
KR49_07490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KR49_07495	COG2217	Heavy metal translocating P-type atpase
KR49_07500	COG3063	Type IV pilus biogenesis stability protein PilW
KR49_07505	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KR49_07515	COG0416	fatty acid biosynthetic process
KR49_07520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KR49_07525	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KR49_07540	COG1214	PFAM Peptidase M22, glycoprotease
KR49_07555	COG0724	RNA recognition motif
KR49_07560	COG1562	ergosterol biosynthetic process
KR49_07565	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
KR49_07565	COG0493	'glutamate synthase
KR49_07580	COG0583	DNA-binding transcription factor activity
KR49_07590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KR49_07595	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR49_07610	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KR49_07620	COG2197	response regulator
KR49_07630	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KR49_07635	COG0713	ATP synthesis coupled electron transport
KR49_07645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR49_07650	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KR49_07655	COG0372	Belongs to the citrate synthase family
KR49_07675	COG1420	regulation of RNA biosynthetic process
KR49_07680	COG0133	tryptophan synthase activity
KR49_07690	COG0023	Translation Initiation Factor
KR49_07695	COG0529	Catalyzes the synthesis of activated sulfate
KR49_07700	COG0628	permease
KR49_07705	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KR49_07715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KR49_07730	COG0564	pseudouridine synthase activity
KR49_07735	COG0745	RESPONSE REGULATOR receiver
KR49_07745	COG1104	cysteine desulfurase activity
KR49_07760	COG0275	rRNA processing
KR49_07765	COG0649	NAD binding
KR49_07770	COG0824	Thioesterase
KR49_07775	COG0318	PFAM AMP-dependent synthetase and ligase
KR49_07785	COG1575	Belongs to the MenA family. Type 1 subfamily
KR49_07795	COG0189	ligase activity
KR49_07800	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KR49_07805	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KR49_07815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KR49_07820	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KR49_07840	COG0252	asparaginase activity
KR49_07845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KR49_07850	COG0018	arginyl-trna synthetase
KR49_07855	COG0157	Belongs to the NadC ModD family
KR49_07860	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KR49_07870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KR49_07875	COG4172	Belongs to the ABC transporter superfamily
KR49_07885	COG0564	pseudouridine synthase activity
KR49_07890	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KR49_07895	COG0589	response to stress
KR49_07900	COG0126	phosphoglycerate kinase activity
KR49_07930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KR49_07935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KR49_07965	COG0167	dihydroorotate dehydrogenase activity
KR49_07970	COG0328	RNA-DNA hybrid ribonuclease activity
KR49_07980	COG0222	ribosome binding
KR49_07985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KR49_07990	COG0081	regulation of translation
KR49_07995	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KR49_08000	COG0250	Participates in transcription elongation, termination and antitermination
KR49_08005	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KR49_08010	COG0542	response to heat
KR49_08015	COG0346	lactoylglutathione lyase activity
KR49_08020	COG0148	phosphopyruvate hydratase activity
KR49_08030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KR49_08075	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KR49_08080	COG0237	dephospho-CoA kinase activity
KR49_08090	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KR49_08095	COG2022	thiamine diphosphate biosynthetic process
KR49_08095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KR49_08100	COG0105	UTP biosynthetic process
KR49_08105	COG1166	arginine decarboxylase activity
KR49_08110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KR49_08120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KR49_08150	COG0426	domain, Protein
KR49_08150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KR49_08155	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KR49_08155	COG0426	domain, Protein
KR49_08160	COG1773	rubredoxin
KR49_08170	COG1741	Belongs to the pirin family
KR49_08185	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KR49_08185	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KR49_08190	COG0509	glycine decarboxylation via glycine cleavage system
KR49_08195	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KR49_08205	COG0359	binds to the 23S rRNA
KR49_08210	COG0305	Participates in initiation and elongation during chromosome replication
KR49_08210	COG1372	Participates in initiation and elongation during chromosome replication
KR49_08210	COG1372	Participates in initiation and elongation during chromosome replication
KR49_08210	COG0305	Participates in initiation and elongation during chromosome replication
KR49_08220	COG0445	tRNA wobble uridine modification
KR49_08265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KR49_08280	COG0398	Pfam SNARE associated Golgi protein
KR49_08295	COG1131	(ABC) transporter
KR49_08300	COG0525	valine-tRNA ligase activity
KR49_08305	COG2182	Extracellular solute-binding protein
KR49_08310	COG0668	transmembrane transport
KR49_08330	COG4221	oxidoreductase activity
KR49_08335	COG3604	Transcriptional regulator
KR49_08375	COG3956	TIGRFAM MazG family protein
KR49_08385	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KR49_08390	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KR49_08395	COG0010	Belongs to the arginase family
KR49_08410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KR49_08415	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KR49_08420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR49_08425	COG0783	Belongs to the Dps family
KR49_08430	COG0504	CTP synthase activity
KR49_08435	COG0602	queuosine metabolic process
KR49_08450	COG1404	Belongs to the peptidase S8 family
KR49_08470	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KR49_08490	COG0366	Alpha amylase catalytic
KR49_08495	COG0463	Glycosyl transferase, family 2
KR49_08520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KR49_08545	COG0411	ABC transporter
KR49_08565	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KR49_08570	COG0830	nickel cation binding
KR49_08575	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
KR49_08580	COG0829	nickel cation binding
KR49_08585	COG0831	urea catabolic process
KR49_08590	COG0832	Belongs to the urease beta subunit family
KR49_08595	COG0804	urea catabolic process
KR49_08600	COG0505	Belongs to the CarA family
KR49_08605	COG2308	Evidence 4 Homologs of previously reported genes of
KR49_08625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KR49_08635	COG2223	nitrite transmembrane transporter activity
KR49_08640	COG0243	molybdopterin cofactor binding
KR49_08660	COG0315	cyclic pyranopterin monophosphate synthase activity
KR49_08665	COG0303	'Molybdopterin
KR49_08685	COG0521	Mo-molybdopterin cofactor biosynthetic process
KR49_08690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KR49_08700	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KR49_08710	COG2116	formate transmembrane transporter activity
KR49_08720	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
KR49_08730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KR49_08745	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KR49_08750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR49_08765	COG0170	dolichyl monophosphate biosynthetic process
KR49_08770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KR49_08775	COG1049	propionate catabolic process, 2-methylcitrate cycle
KR49_08785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KR49_08795	COG0788	formyltetrahydrofolate deformylase activity
KR49_08810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KR49_08820	COG0443	Heat shock 70 kDa protein
KR49_08825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KR49_08835	COG0360	Binds together with S18 to 16S ribosomal RNA
KR49_08845	COG0137	argininosuccinate synthase activity
KR49_08860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KR49_08875	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
KR49_08880	COG0438	transferase activity, transferring glycosyl groups
KR49_08890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KR49_08895	COG0497	DNA recombination
KR49_08900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KR49_08910	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KR49_08915	COG0592	DNA-directed DNA polymerase activity
KR49_08925	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KR49_08930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KR49_08935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KR49_08945	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KR49_08965	COG0552	protein localization to endoplasmic reticulum
KR49_08970	COG2208	phosphoserine phosphatase activity
KR49_08975	COG0165	Argininosuccinate lyase
KR49_08980	COG0724	RNA recognition motif
KR49_08985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KR49_08990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KR49_08995	COG2081	HI0933 family
KR49_09015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KR49_09020	COG0484	heat shock protein binding
KR49_09030	COG1162	GTPase activity
KR49_09035	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KR49_09040	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KR49_09045	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KR49_09050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KR49_09055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KR49_09060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KR49_09065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KR49_09070	COG0511	ligase activity, forming carbon-carbon bonds
KR49_09075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KR49_09150	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
KR49_09155	COG0519	Catalyzes the synthesis of GMP from XMP
KR49_09155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KR49_09170	COG0768	penicillin binding
KR49_09175	COG0438	transferase activity, transferring glycosyl groups
KR49_09180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KR49_09190	COG2022	thiamine diphosphate biosynthetic process
KR49_09205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KR49_09210	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KR49_09215	COG2247	cell wall binding repeat
KR49_09215	COG2385	sporulation resulting in formation of a cellular spore
KR49_09220	COG1215	transferase activity, transferring glycosyl groups
KR49_09225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KR49_09235	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KR49_09240	COG0740	serine-type endopeptidase activity
KR49_09245	COG0544	peptidyl-prolyl cis-trans isomerase activity
KR49_09255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KR49_09260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KR49_09265	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KR49_09285	COG2082	Precorrin-8x methylmutase
KR49_09290	COG0037	tRNA processing
KR49_09305	COG0556	nucleotide-excision repair
KR49_09310	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KR49_09320	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KR49_09335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KR49_09410	COG0653	protein targeting
KR49_09430	COG1045	serine acetyltransferase
KR49_09435	COG1725	Transcriptional regulator
KR49_09440	COG0412	Dienelactone hydrolase
KR49_09445	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KR49_09450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KR49_09455	COG1372	Participates in initiation and elongation during chromosome replication
KR49_09455	COG0187	DNA topoisomerase II activity
KR49_09465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KR49_09470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KR49_09480	COG0386	Belongs to the glutathione peroxidase family
KR49_09485	COG2239	Acts as a magnesium transporter
KR49_09490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR49_09495	COG0596	Alpha beta hydrolase
KR49_09505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KR49_09510	COG0802	atpase or kinase
KR49_09515	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KR49_09520	COG0586	Pfam SNARE associated Golgi protein
KR49_09525	COG0629	single-stranded DNA binding
KR49_09535	COG1792	Involved in formation and maintenance of cell shape
KR49_09550	COG0745	RESPONSE REGULATOR receiver
KR49_09555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KR49_09575	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
KR49_09580	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KR49_09585	COG0515	serine threonine protein kinase
KR49_09585	COG3266	domain, Protein
KR49_09590	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KR49_09595	COG2255	four-way junction helicase activity
KR49_09605	COG1473	amidohydrolase
KR49_09625	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KR49_09635	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KR49_09640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KR49_09645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KR49_09650	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR49_09655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KR49_09660	COG0598	Magnesium transport protein CorA
KR49_09670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KR49_09680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KR49_09685	COG0571	ribonuclease III activity
KR49_09720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KR49_09725	COG0058	SHG alpha-glucan phosphorylase activity
KR49_09730	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
KR49_09735	COG0475	glutathione-regulated potassium exporter activity
KR49_09755	COG0277	FAD linked oxidase domain protein
KR49_09765	COG0247	lactate metabolic process
KR49_09775	COG0538	isocitrate dehydrogenase activity
KR49_09785	COG0463	Glycosyl transferase, family 2
KR49_09795	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KR49_09805	COG5398	heme oxygenase
KR49_09820	COG0438	transferase activity, transferring glycosyl groups
KR49_09830	COG0438	transferase activity, transferring glycosyl groups
KR49_09835	COG0297	glycogen (starch) synthase activity
KR49_09855	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KR49_09860	COG0463	Glycosyl transferase, family 2
KR49_09880	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KR49_09885	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KR49_09890	COG0517	IMP dehydrogenase activity
KR49_09890	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KR49_09895	COG0617	tRNA 3'-terminal CCA addition
KR49_09905	COG0709	Synthesizes selenophosphate from selenide and ATP
KR49_09910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KR49_09920	COG2274	protein secretion by the type I secretion system
KR49_09930	COG0438	transferase activity, transferring glycosyl groups
KR49_09935	COG0124	histidyl-tRNA synthetase
KR49_09945	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KR49_09975	COG4447	cellulose binding
KR49_09985	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR49_09990	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR49_09995	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR49_10000	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KR49_10005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KR49_10015	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
KR49_10015	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
KR49_10020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KR49_10025	COG0494	nUDIX hydrolase
KR49_10030	COG0415	Belongs to the DNA photolyase family
KR49_10060	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KR49_10065	COG0131	Imidazoleglycerol-phosphate dehydratase
KR49_10070	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
KR49_10080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KR49_10100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KR49_10105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KR49_10115	COG0354	folic acid binding
KR49_10120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KR49_10130	COG1253	flavin adenine dinucleotide binding
KR49_10135	COG0673	inositol 2-dehydrogenase activity
KR49_10155	COG0343	queuine tRNA-ribosyltransferase activity
KR49_10180	COG0138	bifunctional purine biosynthesis protein purh
KR49_10195	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KR49_10200	COG0004	ammonium transporteR
KR49_10205	COG1489	DNA binding
KR49_10210	COG0728	peptidoglycan biosynthetic process
KR49_10240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KR49_10245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KR49_10250	COG1058	Belongs to the CinA family
KR49_10250	COG1546	Belongs to the CinA family
KR49_10255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KR49_10260	COG0066	3-isopropylmalate dehydratase activity
KR49_10295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KR49_10300	COG0193	aminoacyl-tRNA hydrolase activity
KR49_10315	COG4372	Transposase
KR49_10325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KR49_10335	COG0717	Belongs to the dCTP deaminase family
KR49_10345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KR49_10355	COG0741	lytic transglycosylase activity
KR49_10365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KR49_10370	COG2971	BadF BadG BcrA BcrD
KR49_10380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KR49_10400	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KR49_10420	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KR49_10435	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KR49_10440	COG2094	Belongs to the DNA glycosylase MPG family
KR49_10445	COG0540	Belongs to the ATCase OTCase family
KR49_10480	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KR49_10490	COG2046	Belongs to the sulfate adenylyltransferase family
KR49_10490	COG0529	Catalyzes the synthesis of activated sulfate
KR49_10495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KR49_10500	COG0800	Aldolase
KR49_10510	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KR49_10555	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KR49_10560	COG0436	Aminotransferase
KR49_10570	COG1530	ribonuclease E activity
KR49_10590	COG2226	methyltransferase
KR49_10595	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KR49_10600	COG0051	transcription antitermination factor activity, RNA binding
KR49_10605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KR49_10610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KR49_10615	COG0049	tRNA binding
KR49_10620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KR49_10635	COG0069	glutamate synthase activity
KR49_10635	COG0067	glutamate synthase
KR49_10635	COG0070	glutamate synthase
KR49_10645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KR49_10665	COG3659	wide pore channel activity
KR49_10680	COG1840	ABC-type Fe3 transport system, periplasmic component
KR49_10695	COG3659	wide pore channel activity
KR49_10700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KR49_10720	COG2885	chlorophyll binding
KR49_10725	COG2885	chlorophyll binding
KR49_10765	COG0463	Glycosyl transferase, family 2
KR49_10790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KR49_10800	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KR49_10805	COG0254	rRNA binding
KR49_10810	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KR49_10815	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KR49_10820	COG0101	tRNA pseudouridine synthase activity
KR49_10825	COG0203	ribosomal protein L17
KR49_10830	COG0202	RNA polymerase activity
KR49_10835	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KR49_10840	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KR49_10845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KR49_10850	COG0563	adenylate kinase activity
KR49_10855	COG0201	protein transport
KR49_10860	COG0200	Binds to the 23S rRNA
KR49_10865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KR49_10870	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KR49_10875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KR49_10880	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KR49_10885	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KR49_10890	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KR49_10895	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KR49_10900	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KR49_10905	COG0255	Belongs to the universal ribosomal protein uL29 family
KR49_10910	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KR49_10915	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KR49_10920	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KR49_10925	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KR49_10930	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KR49_10935	COG0089	rRNA binding
KR49_10940	COG0088	Forms part of the polypeptide exit tunnel
KR49_10945	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KR49_10960	COG3854	ATPases associated with a variety of cellular activities
KR49_10975	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KR49_11025	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
KR49_11030	COG1606	tRNA processing
KR49_11035	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KR49_11055	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KR49_11065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KR49_11080	COG0772	Belongs to the SEDS family
KR49_11085	COG0489	protein tyrosine kinase activity
KR49_11090	COG0408	coproporphyrinogen oxidase activity
KR49_11110	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KR49_11140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KR49_11145	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KR49_11150	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KR49_11150	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KR49_11155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KR49_11215	COG0237	dephospho-CoA kinase activity
KR49_11295	COG0237	dephospho-CoA kinase activity
KR49_11315	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KR49_11350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KR49_11365	COG1070	Carbohydrate kinase
KR49_11370	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KR49_11380	COG0539	negative regulation of cytoplasmic translation
KR49_11385	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KR49_11410	COG0589	response to stress
KR49_11420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KR49_11420	COG0758	DNA mediated transformation
KR49_11425	COG2890	protein-(glutamine-N5) methyltransferase activity
KR49_11450	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KR49_11455	COG2894	cell division
KR49_11460	COG0850	regulation of cytokinetic process
KR49_11465	COG1078	dGTPase activity
KR49_11470	COG0793	Belongs to the peptidase S41A family
KR49_11475	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KR49_11480	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KR49_11515	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KR49_11530	COG0514	ATP-dependent DNA helicase (RecQ)
KR49_11535	COG3942	CHAP domain
KR49_11535	COG1388	LysM domain
KR49_11540	COG1012	belongs to the aldehyde dehydrogenase family
KR49_11550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KR49_11575	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KR49_11585	COG0659	secondary active sulfate transmembrane transporter activity
KR49_11590	COG4243	Vitamin k epoxide reductase
KR49_11595	COG0484	heat shock protein binding
KR49_11600	COG0113	porphobilinogen synthase activity
KR49_11610	COG1193	negative regulation of DNA recombination
KR49_11615	COG3842	ATPase activity
KR49_11620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KR49_11635	COG0488	(ABC) transporter
KR49_11645	COG0435	Glutathione S-transferase
KR49_11650	COG2988	succinylglutamate desuccinylase activity
KR49_11720	COG4176	ABC-type proline glycine betaine transport system permease component
KR49_11730	COG2226	methyltransferase
KR49_11735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KR49_11915	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KR49_11925	COG1185	polyribonucleotide nucleotidyltransferase activity
KR49_11930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KR49_11935	COG0750	zinc metalloprotease
KR49_11940	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KR49_11960	COG0706	membrane insertase activity
KR49_11970	COG0594	ribonuclease P activity
KR49_11990	COG0616	signal peptide processing
KR49_11995	COG0697	spore germination
KR49_12000	COG0438	transferase activity, transferring glycosyl groups
KR49_12005	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KR49_12015	COG1842	Phage shock protein A
KR49_12020	COG3118	belongs to the thioredoxin family
KR49_12025	COG0436	Aminotransferase
KR49_12030	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KR49_12030	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KR49_12035	COG0739	heme binding
KR49_12040	COG0745	RESPONSE REGULATOR receiver
KR49_12050	COG0577	efflux transmembrane transporter activity
KR49_12050	COG1136	(ABC) transporter
KR49_12055	COG1007	ATP synthesis coupled electron transport
KR49_12060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KR49_12075	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KR49_12105	COG1845	cytochrome c oxidase, subunit III
KR49_12120	COG1612	heme a metabolic process
KR49_12125	COG0109	protoheme IX farnesyltransferase activity
KR49_12145	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
KR49_12150	COG0459	protein refolding
KR49_12160	COG1028	Short-chain dehydrogenase reductase Sdr
KR49_12175	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KR49_12180	COG1619	proteins homologs of microcin C7 resistance protein MccF
KR49_12185	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KR49_12190	COG0248	Ppx GppA phosphatase
KR49_12205	COG2875	Belongs to the precorrin methyltransferase family
KR49_12210	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KR49_12215	COG0739	heme binding
KR49_12220	COG0723	plastoquinol--plastocyanin reductase activity
KR49_12230	COG0805	protein transport
KR49_12240	COG0194	GDP metabolic process
KR49_12255	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KR49_12260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KR49_12290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KR49_12310	COG0335	large ribosomal subunit rRNA binding
KR49_12320	COG0024	Methionine aminopeptidase
KR49_12325	COG3000	fatty acid hydroxylase
KR49_12325	COG0300	oxidoreductase activity
KR49_12335	COG0857	belongs to the CobB CobQ family
KR49_12350	COG1666	GTP binding
KR49_12370	COG0295	cytidine deaminase activity
KR49_12380	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KR49_12385	COG0277	FAD linked oxidase domain protein
KR49_12390	COG0708	Exodeoxyribonuclease III
KR49_12410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KR49_12415	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
KR49_12440	COG1840	ABC-type Fe3 transport system, periplasmic component
KR49_12450	COG0523	cobalamin synthesis protein
KR49_12455	COG2154	pterin-4-alpha-carbinolamine dehydratase
KR49_12460	COG0432	Pfam Uncharacterised protein family UPF0047
KR49_12470	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KR49_12475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KR49_12490	COG0181	hydroxymethylbilane synthase activity
KR49_12510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR49_12520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KR49_12530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KR49_12545	COG0629	single-stranded DNA binding
KR49_12550	COG2099	Precorrin-6x reductase
KR49_12555	COG1324	tolerance protein
KR49_12560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KR49_12565	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KR49_12575	COG0442	prolyl-tRNA aminoacylation
KR49_12590	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KR49_12620	COG0406	alpha-ribazole phosphatase activity
KR49_12635	COG0768	penicillin binding
KR49_12640	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KR49_12655	COG0415	Belongs to the DNA photolyase family
KR49_12670	COG0233	cytoplasmic translational termination
KR49_12675	COG0528	UMP kinase activity
KR49_12700	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KR49_12705	COG0028	Belongs to the TPP enzyme family
KR49_12720	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KR49_12735	COG0539	negative regulation of cytoplasmic translation
KR49_12745	COG3396	Phenylacetate-CoA oxygenase
KR49_12750	COG5322	oxidoreductase activity
KR49_12755	COG0825	malonyl-CoA metabolic process
KR49_12760	COG4221	oxidoreductase activity
KR49_12765	COG0302	gtp cyclohydrolase
KR49_12770	COG0135	phosphoribosylanthranilate isomerase activity
KR49_12775	COG0517	IMP dehydrogenase activity
KR49_12775	COG1994	Peptidase M50
KR49_12785	COG0730	response to heat
KR49_12810	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
KR49_12815	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
KR49_12820	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
KR49_12835	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KR49_12850	COG1850	ribulose-bisphosphate carboxylase activity
KR49_12855	COG4451	ribulose bisphosphate carboxylase, small
KR49_12885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KR49_12890	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR49_12920	COG1492	cobalamin metabolic process
KR49_12930	COG0424	maF-like protein
KR49_12935	COG0668	transmembrane transport
KR49_12960	COG0367	asparagine synthase
KR49_12965	COG0540	Belongs to the ATCase OTCase family
KR49_12985	COG3239	Fatty acid desaturase
KR49_12995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KR49_13000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KR49_13010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KR49_13015	COG0668	transmembrane transport
KR49_13045	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KR49_13050	COG0579	oxidoreductase
KR49_13060	COG0481	GTPase activity
KR49_13100	COG0745	RESPONSE REGULATOR receiver
KR49_13130	COG3850	Histidine kinase
KR49_13130	COG5002	protein histidine kinase activity
KR49_13150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KR49_13160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KR49_13160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KR49_13165	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KR49_13170	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KR49_13180	COG0107	imidazoleglycerol-phosphate synthase activity
KR49_13190	COG2226	methyltransferase
KR49_13210	COG0752	glycyl-tRNA synthetase alpha subunit
KR49_13225	COG0582	viral genome integration into host DNA
KR49_13330	COG4974	Belongs to the 'phage' integrase family
KR49_13535	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KR49_13540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KR49_13545	COG0740	serine-type endopeptidase activity
KR49_13550	COG0740	serine-type endopeptidase activity
KR49_13555	COG4956	integral membrane protein (PIN domain superfamily)
KR49_13560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KR49_13565	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KR49_13570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KR49_13585	COG1181	Belongs to the D-alanine--D-alanine ligase family
KR49_13590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KR49_13595	COG4948	Mandelate Racemase Muconate Lactonizing
KR49_13630	COG0285	dihydrofolate synthase activity
KR49_13635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KR49_13640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KR49_13645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KR49_13660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KR49_13665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KR49_13670	COG0134	indole-3-glycerol-phosphate synthase activity
KR49_13700	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KR49_13705	COG0482	sulfurtransferase activity
KR49_13710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR49_13715	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KR49_13725	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KR49_13730	COG0228	four-way junction DNA binding
KR49_13735	COG1702	phosphate starvation-inducible protein PhoH
KR49_13740	COG0670	Belongs to the BI1 family
KR49_13750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KR49_13765	COG0336	Belongs to the RNA methyltransferase TrmD family
KR49_13775	COG1691	(AIR) carboxylase
KR49_13795	COG0352	thiamine-phosphate diphosphorylase activity
KR49_13805	COG0196	riboflavin kinase activity
KR49_13815	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KR49_13820	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KR49_13825	COG3119	arylsulfatase activity
KR49_13830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KR49_13885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KR49_13890	COG0745	RESPONSE REGULATOR receiver
KR49_13925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KR49_13925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate