locus-tag	class	description
KR52_00010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KR52_00015	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KR52_00020	COG0793	Belongs to the peptidase S41A family
KR52_00025	COG1078	dGTPase activity
KR52_00030	COG0850	regulation of cytokinetic process
KR52_00035	COG2894	cell division
KR52_00040	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KR52_00060	COG0009	L-threonylcarbamoyladenylate synthase
KR52_00065	COG2890	protein-(glutamine-N5) methyltransferase activity
KR52_00070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KR52_00070	COG0758	DNA mediated transformation
KR52_00080	COG0589	response to stress
KR52_00105	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KR52_00110	COG0539	negative regulation of cytoplasmic translation
KR52_00115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KR52_00120	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KR52_00125	COG1070	Carbohydrate kinase
KR52_00175	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KR52_00330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KR52_00335	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KR52_00335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KR52_00340	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KR52_00350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KR52_00390	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KR52_00410	COG0408	coproporphyrinogen oxidase activity
KR52_00415	COG0489	protein tyrosine kinase activity
KR52_00420	COG0772	Belongs to the SEDS family
KR52_00435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KR52_00440	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KR52_00445	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KR52_00460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KR52_00465	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KR52_00470	COG1606	tRNA processing
KR52_00475	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
KR52_00500	COG1233	COG1233 Phytoene dehydrogenase and related
KR52_00525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KR52_00540	COG3854	ATPases associated with a variety of cellular activities
KR52_00555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KR52_00560	COG0088	Forms part of the polypeptide exit tunnel
KR52_00565	COG0089	rRNA binding
KR52_00570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KR52_00575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KR52_00580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KR52_00585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KR52_00590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KR52_00595	COG0255	Belongs to the universal ribosomal protein uL29 family
KR52_00600	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KR52_00605	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KR52_00610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KR52_00615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KR52_00620	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KR52_00625	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KR52_00630	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KR52_00635	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KR52_00640	COG0200	Binds to the 23S rRNA
KR52_00645	COG0201	protein transport
KR52_00650	COG0563	adenylate kinase activity
KR52_00655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KR52_00660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KR52_00665	COG0202	RNA polymerase activity
KR52_00670	COG0203	ribosomal protein L17
KR52_00675	COG0101	tRNA pseudouridine synthase activity
KR52_00680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KR52_00685	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KR52_00690	COG0254	rRNA binding
KR52_00695	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KR52_00705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KR52_00725	COG0463	Glycosyl transferase, family 2
KR52_00760	COG2885	chlorophyll binding
KR52_00765	COG2885	chlorophyll binding
KR52_00795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KR52_00805	COG0069	glutamate synthase activity
KR52_00805	COG0070	glutamate synthase
KR52_00805	COG0067	glutamate synthase
KR52_00820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KR52_00825	COG0049	tRNA binding
KR52_00830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KR52_00835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KR52_00840	COG0051	transcription antitermination factor activity, RNA binding
KR52_00845	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KR52_00850	COG2226	methyltransferase
KR52_00865	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KR52_00870	COG1530	ribonuclease E activity
KR52_00880	COG0436	Aminotransferase
KR52_00885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KR52_00895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KR52_00925	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KR52_00940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KR52_00945	COG2046	Belongs to the sulfate adenylyltransferase family
KR52_00945	COG0529	Catalyzes the synthesis of activated sulfate
KR52_00960	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KR52_00965	COG3536	Protein conserved in bacteria
KR52_00995	COG0540	Belongs to the ATCase OTCase family
KR52_01000	COG2094	Belongs to the DNA glycosylase MPG family
KR52_01025	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KR52_01040	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KR52_01060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KR52_01080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KR52_01095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KR52_01100	COG0741	lytic transglycosylase activity
KR52_01110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KR52_01120	COG0717	Belongs to the dCTP deaminase family
KR52_01130	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KR52_01135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KR52_01140	COG4372	Transposase
KR52_01155	COG0193	aminoacyl-tRNA hydrolase activity
KR52_01160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KR52_01195	COG0066	3-isopropylmalate dehydratase activity
KR52_01200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KR52_01205	COG1546	Belongs to the CinA family
KR52_01205	COG1058	Belongs to the CinA family
KR52_01210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KR52_01215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KR52_01240	COG0728	peptidoglycan biosynthetic process
KR52_01245	COG1489	DNA binding
KR52_01250	COG0004	ammonium transporteR
KR52_01255	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KR52_01270	COG0138	bifunctional purine biosynthesis protein purh
KR52_01290	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
KR52_01295	COG0343	queuine tRNA-ribosyltransferase activity
KR52_01305	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KR52_01315	COG0673	inositol 2-dehydrogenase activity
KR52_01320	COG1253	flavin adenine dinucleotide binding
KR52_01330	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KR52_01335	COG0354	folic acid binding
KR52_01350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KR52_01365	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
KR52_01370	COG0131	Imidazoleglycerol-phosphate dehydratase
KR52_01375	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KR52_01410	COG1181	Belongs to the D-alanine--D-alanine ligase family
KR52_01425	COG0415	Belongs to the DNA photolyase family
KR52_01430	COG0494	nUDIX hydrolase
KR52_01435	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KR52_01445	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
KR52_01445	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
KR52_01455	COG3842	ATPase activity
KR52_01460	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KR52_01465	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR52_01470	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR52_01475	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR52_01485	COG4447	cellulose binding
KR52_01550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KR52_01555	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
KR52_01565	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KR52_01575	COG0124	histidyl-tRNA synthetase
KR52_01580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KR52_01585	COG0709	Synthesizes selenophosphate from selenide and ATP
KR52_01600	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KR52_01600	COG0517	IMP dehydrogenase activity
KR52_01605	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KR52_01610	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KR52_01635	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KR52_01650	COG0438	transferase activity, transferring glycosyl groups
KR52_01655	COG0438	transferase activity, transferring glycosyl groups
KR52_01660	COG0438	transferase activity, transferring glycosyl groups
KR52_01675	COG5398	heme oxygenase
KR52_01685	COG0235	Class ii aldolase
KR52_01690	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KR52_01705	COG0538	isocitrate dehydrogenase activity
KR52_01720	COG0247	lactate metabolic process
KR52_01730	COG0277	FAD linked oxidase domain protein
KR52_01750	COG0475	glutathione-regulated potassium exporter activity
KR52_01755	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
KR52_01760	COG0058	SHG alpha-glucan phosphorylase activity
KR52_01765	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KR52_01785	COG0571	ribonuclease III activity
KR52_01790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KR52_01800	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KR52_01810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KR52_01815	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR52_01820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KR52_01825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KR52_01830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KR52_01835	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KR52_01850	COG1473	amidohydrolase
KR52_01860	COG2255	four-way junction helicase activity
KR52_01865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KR52_01875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KR52_01880	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
KR52_01900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KR52_01920	COG1792	Involved in formation and maintenance of cell shape
KR52_01930	COG0629	single-stranded DNA binding
KR52_01935	COG0586	Pfam SNARE associated Golgi protein
KR52_01940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KR52_01945	COG0802	atpase or kinase
KR52_01955	COG1194	a g-specific adenine glycosylase
KR52_02000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR52_02005	COG2239	Acts as a magnesium transporter
KR52_02010	COG0386	Belongs to the glutathione peroxidase family
KR52_02015	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KR52_02020	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KR52_02030	COG0187	DNA topoisomerase II activity
KR52_02030	COG1372	Participates in initiation and elongation during chromosome replication
KR52_02035	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KR52_02040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KR52_02045	COG0412	Dienelactone hydrolase
KR52_02050	COG1725	Transcriptional regulator
KR52_02055	COG1045	serine acetyltransferase
KR52_02060	COG0653	protein targeting
KR52_02070	COG0556	nucleotide-excision repair
KR52_02080	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KR52_02090	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KR52_02105	COG0037	tRNA processing
KR52_02110	COG2082	Precorrin-8x methylmutase
KR52_02130	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KR52_02135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KR52_02140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KR52_02145	COG0544	peptidyl-prolyl cis-trans isomerase activity
KR52_02150	COG0740	serine-type endopeptidase activity
KR52_02155	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KR52_02165	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KR52_02170	COG1215	transferase activity, transferring glycosyl groups
KR52_02175	COG2385	sporulation resulting in formation of a cellular spore
KR52_02180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KR52_02185	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KR52_02200	COG2022	thiamine diphosphate biosynthetic process
KR52_02210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KR52_02215	COG0438	transferase activity, transferring glycosyl groups
KR52_02240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KR52_02240	COG0519	Catalyzes the synthesis of GMP from XMP
KR52_02245	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
KR52_02305	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KR52_02310	COG0511	ligase activity, forming carbon-carbon bonds
KR52_02315	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KR52_02320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KR52_02325	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KR52_02330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KR52_02335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KR52_02340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KR52_02345	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KR52_02350	COG1162	GTPase activity
KR52_02360	COG0484	heat shock protein binding
KR52_02365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KR52_02385	COG2081	HI0933 family
KR52_02395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KR52_02400	COG0724	RNA recognition motif
KR52_02405	COG0165	Argininosuccinate lyase
KR52_02410	COG2208	phosphoserine phosphatase activity
KR52_02415	COG0552	protein localization to endoplasmic reticulum
KR52_02420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KR52_02435	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KR52_02445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KR52_02455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KR52_02465	COG0592	DNA-directed DNA polymerase activity
KR52_02470	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KR52_02480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KR52_02485	COG0497	DNA recombination
KR52_02490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KR52_02500	COG0438	transferase activity, transferring glycosyl groups
KR52_02505	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
KR52_02510	COG1376	ErfK ybiS ycfS ynhG family protein
KR52_02540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KR52_02555	COG0137	argininosuccinate synthase activity
KR52_02565	COG0360	Binds together with S18 to 16S ribosomal RNA
KR52_02575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KR52_02580	COG0443	Heat shock 70 kDa protein
KR52_02585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KR52_02585	COG2022	thiamine diphosphate biosynthetic process
KR52_02595	COG0788	formyltetrahydrofolate deformylase activity
KR52_02605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KR52_02615	COG1049	propionate catabolic process, 2-methylcitrate cycle
KR52_02620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KR52_02625	COG0170	dolichyl monophosphate biosynthetic process
KR52_02630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR52_02635	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KR52_02650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KR52_02660	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
KR52_02670	COG2116	formate transmembrane transporter activity
KR52_02680	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KR52_02695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KR52_02700	COG0521	Mo-molybdopterin cofactor biosynthetic process
KR52_02710	COG0314	molybdopterin synthase activity
KR52_02725	COG0303	'Molybdopterin
KR52_02730	COG0315	cyclic pyranopterin monophosphate synthase activity
KR52_02750	COG0243	molybdopterin cofactor binding
KR52_02755	COG2223	nitrite transmembrane transporter activity
KR52_02760	COG0746	molybdenum cofactor guanylyltransferase activity
KR52_02765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KR52_02785	COG2308	Evidence 4 Homologs of previously reported genes of
KR52_02805	COG0540	Belongs to the ATCase OTCase family
KR52_02810	COG0367	asparagine synthase
KR52_02835	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KR52_02840	COG0804	urea catabolic process
KR52_02845	COG0832	Belongs to the urease beta subunit family
KR52_02850	COG0831	urea catabolic process
KR52_02855	COG0829	nickel cation binding
KR52_02860	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
KR52_02865	COG0830	nickel cation binding
KR52_02870	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KR52_02890	COG0411	ABC transporter
KR52_02910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KR52_02930	COG0463	Glycosyl transferase, family 2
KR52_02935	COG0366	Alpha amylase catalytic
KR52_02955	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KR52_02960	COG2084	Dehydrogenase
KR52_02965	COG0602	queuosine metabolic process
KR52_02970	COG0504	CTP synthase activity
KR52_02975	COG0783	Belongs to the Dps family
KR52_02980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR52_02985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KR52_02990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KR52_03005	COG0010	Belongs to the arginase family
KR52_03010	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KR52_03020	COG3956	TIGRFAM MazG family protein
KR52_03095	COG4221	oxidoreductase activity
KR52_03100	COG2226	methyltransferase
KR52_03130	COG0525	valine-tRNA ligase activity
KR52_03135	COG1131	(ABC) transporter
KR52_03160	COG0398	Pfam SNARE associated Golgi protein
KR52_03170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KR52_03210	COG0445	tRNA wobble uridine modification
KR52_03215	COG0305	Participates in initiation and elongation during chromosome replication
KR52_03215	COG0305	Participates in initiation and elongation during chromosome replication
KR52_03215	COG1372	Participates in initiation and elongation during chromosome replication
KR52_03215	COG1372	Participates in initiation and elongation during chromosome replication
KR52_03220	COG0359	binds to the 23S rRNA
KR52_03230	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KR52_03235	COG0509	glycine decarboxylation via glycine cleavage system
KR52_03240	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KR52_03240	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KR52_03255	COG1741	Belongs to the pirin family
KR52_03270	COG0426	domain, Protein
KR52_03270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KR52_03285	COG0426	domain, Protein
KR52_03285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KR52_03290	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KR52_03300	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KR52_03325	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KR52_03335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KR52_03355	COG1166	arginine decarboxylase activity
KR52_03360	COG0105	UTP biosynthetic process
KR52_03395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KR52_03430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KR52_03430	COG2022	thiamine diphosphate biosynthetic process
KR52_03440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KR52_03465	COG0237	dephospho-CoA kinase activity
KR52_03470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KR52_03525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KR52_03530	COG0148	phosphopyruvate hydratase activity
KR52_03535	COG0346	lactoylglutathione lyase activity
KR52_03540	COG0542	response to heat
KR52_03545	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KR52_03550	COG0250	Participates in transcription elongation, termination and antitermination
KR52_03555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KR52_03560	COG0081	regulation of translation
KR52_03565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KR52_03570	COG0222	ribosome binding
KR52_03580	COG0328	RNA-DNA hybrid ribonuclease activity
KR52_03585	COG0167	dihydroorotate dehydrogenase activity
KR52_03610	COG1450	Type ii and iii secretion system protein
KR52_03620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KR52_03625	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KR52_03645	COG0126	phosphoglycerate kinase activity
KR52_03650	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KR52_03665	COG2124	cytochrome p450
KR52_03680	COG0564	pseudouridine synthase activity
KR52_03685	COG4172	Belongs to the ABC transporter superfamily
KR52_03690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KR52_03700	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KR52_03715	COG0157	Belongs to the NadC ModD family
KR52_03720	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KR52_03725	COG1454	alcohol dehydrogenase
KR52_03735	COG0018	arginyl-trna synthetase
KR52_03780	COG2202	Pas domain
KR52_03780	COG2200	EAL domain
KR52_03780	COG2199	diguanylate cyclase activity
KR52_03785	COG0668	transmembrane transport
KR52_03815	COG3621	Patatin-like phospholipase
KR52_03820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KR52_03825	COG0252	asparaginase activity
KR52_03850	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KR52_03855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KR52_03865	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KR52_03870	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KR52_03875	COG0189	ligase activity
KR52_03885	COG1575	Belongs to the MenA family. Type 1 subfamily
KR52_03900	COG0824	Thioesterase
KR52_03920	COG0649	NAD binding
KR52_03925	COG0275	rRNA processing
KR52_03935	COG1104	cysteine desulfurase activity
KR52_03945	COG0745	RESPONSE REGULATOR receiver
KR52_03950	COG0564	pseudouridine synthase activity
KR52_03960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KR52_03970	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KR52_03980	COG0628	permease
KR52_03985	COG0529	Catalyzes the synthesis of activated sulfate
KR52_03990	COG0023	Translation Initiation Factor
KR52_04000	COG0133	tryptophan synthase activity
KR52_04005	COG1420	regulation of RNA biosynthetic process
KR52_04025	COG0372	Belongs to the citrate synthase family
KR52_04030	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KR52_04035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR52_04045	COG0713	ATP synthesis coupled electron transport
KR52_04050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KR52_04060	COG2197	response regulator
KR52_04070	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KR52_04085	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR52_04090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KR52_04100	COG0583	DNA-binding transcription factor activity
KR52_04115	COG0493	'glutamate synthase
KR52_04115	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
KR52_04120	COG1562	ergosterol biosynthetic process
KR52_04125	COG0724	RNA recognition motif
KR52_04140	COG1214	PFAM Peptidase M22, glycoprotease
KR52_04150	COG0204	Acyl-transferase
KR52_04150	COG0318	PFAM AMP-dependent synthetase and ligase
KR52_04155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KR52_04160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KR52_04165	COG0416	fatty acid biosynthetic process
KR52_04175	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KR52_04180	COG3063	Type IV pilus biogenesis stability protein PilW
KR52_04185	COG2217	Heavy metal translocating P-type atpase
KR52_04190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KR52_04200	COG0745	RESPONSE REGULATOR receiver
KR52_04210	COG1122	ATPase activity
KR52_04255	COG1215	transferase activity, transferring glycosyl groups
KR52_04270	COG3659	wide pore channel activity
KR52_04275	COG3659	wide pore channel activity
KR52_04280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KR52_04285	COG0484	heat shock protein binding
KR52_04300	COG1090	epimerase
KR52_04325	COG0316	Belongs to the HesB IscA family
KR52_04330	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
KR52_04345	COG1587	Uroporphyrinogen-III synthase
KR52_04350	COG0457	Tetratricopeptide repeat
KR52_04350	COG0463	Glycosyl transferase, family 2
KR52_04355	COG1472	Belongs to the glycosyl hydrolase 3 family
KR52_04360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KR52_04385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KR52_04410	COG1032	radical SAM domain protein
KR52_04425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KR52_04430	COG4243	Vitamin k epoxide reductase
KR52_04435	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KR52_04440	COG1555	photosystem II stabilization
KR52_04450	COG1968	undecaprenyl-diphosphatase activity
KR52_04540	COG1570	exodeoxyribonuclease VII activity
KR52_04555	COG1643	Atp-dependent helicase
KR52_04575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KR52_04585	COG0488	(ABC) transporter
KR52_04610	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KR52_04615	COG0569	domain protein
KR52_04620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KR52_04625	COG0471	metal ion transport
KR52_04625	COG3273	potassium ion transport
KR52_04630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KR52_04635	COG1252	NADH dehydrogenase
KR52_04640	COG0175	sulfate reduction
KR52_04645	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KR52_04650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KR52_04665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KR52_04670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KR52_04675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KR52_04685	COG0033	Phosphoglucomutase
KR52_04720	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KR52_04740	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
KR52_04745	COG0719	Fe-S assembly protein
KR52_04750	COG0396	ATPase activity
KR52_04755	COG0719	Fe-S assembly protein
KR52_04760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KR52_04780	COG0242	peptide deformylase activity
KR52_04800	COG0606	chelatase, subunit chli
KR52_04805	COG0537	adenosine 5'-monophosphoramidase activity
KR52_04810	COG4178	(ABC) transporter
KR52_04815	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KR52_04830	COG0515	serine threonine protein kinase
KR52_04845	COG0439	Biotin carboxylase
KR52_04860	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KR52_04870	COG1196	nuclear chromosome segregation
KR52_04890	COG3263	regulation of cellular component size
KR52_04895	COG0116	Belongs to the methyltransferase superfamily
KR52_04985	COG2089	acid synthase
KR52_05000	COG1083	cytidylyl-transferase
KR52_05010	COG3562	capsule polysaccharide
KR52_05020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KR52_05035	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KR52_05045	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KR52_05050	COG1333	cytochrome c biogenesis protein
KR52_05060	COG0772	Belongs to the SEDS family
KR52_05090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KR52_05095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KR52_05105	COG0356	it plays a direct role in the translocation of protons across the membrane
KR52_05110	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KR52_05120	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KR52_05125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KR52_05130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KR52_05135	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KR52_05145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KR52_05155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KR52_05160	COG3012	SEC-C Motif Domain Protein
KR52_05165	COG0686	Belongs to the AlaDH PNT family
KR52_05170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KR52_05170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KR52_05180	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KR52_05185	COG1253	flavin adenine dinucleotide binding
KR52_05190	COG0006	proline dipeptidase activity
KR52_05195	COG0387	Pfam Sodium calcium exchanger
KR52_05210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KR52_05215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KR52_05220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KR52_05225	COG0459	protein refolding
KR52_05260	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KR52_05265	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KR52_05280	COG0443	Heat shock 70 kDa protein
KR52_05315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KR52_05335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KR52_05340	COG2264	protein methyltransferase activity
KR52_05355	COG2010	Cytochrome c
KR52_05360	COG1234	tRNA 3'-trailer cleavage
KR52_05365	COG2247	cell wall binding repeat
KR52_05365	COG2385	sporulation resulting in formation of a cellular spore
KR52_05370	COG0363	glucosamine-6-phosphate deaminase activity
KR52_05425	COG0217	transcriptional regulatory protein
KR52_05430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KR52_05440	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KR52_05445	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KR52_05455	COG4251	negative regulation of phosphorylation
KR52_05460	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KR52_05465	COG5002	protein histidine kinase activity
KR52_05470	COG0151	Belongs to the GarS family
KR52_05480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KR52_05490	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KR52_05495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KR52_05500	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KR52_05505	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KR52_05510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KR52_05525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KR52_05560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KR52_05565	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KR52_05570	COG0284	orotidine-5'-phosphate decarboxylase activity
KR52_05575	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KR52_05590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KR52_05595	COG2211	Major facilitator Superfamily
KR52_05615	COG0776	regulation of translation
KR52_05620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KR52_05645	COG1053	succinate dehydrogenase
KR52_05830	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KR52_05840	COG0195	Participates in both transcription termination and antitermination
KR52_05845	COG0779	Required for maturation of 30S ribosomal subunits
KR52_05860	COG0641	radical SAM
KR52_05875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KR52_05880	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KR52_05885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KR52_05890	COG0268	Binds directly to 16S ribosomal RNA
KR52_05895	COG0084	hydrolase, TatD family'
KR52_05900	COG0085	RNA polymerase activity
KR52_05905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KR52_05910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KR52_05915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KR52_05920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KR52_05960	COG0357	Ribosomal RNA small subunit methyltransferase G
KR52_05975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KR52_05990	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KR52_06005	COG0156	8-amino-7-oxononanoate synthase activity
KR52_06010	COG0385	Bile acid
KR52_06055	COG4581	dead DEAH box helicase
KR52_06060	COG0114	fumarate hydratase activity
KR52_06090	COG1088	dTDP-glucose 4,6-dehydratase activity
KR52_06095	COG1091	dTDP-4-dehydrorhamnose reductase activity
KR52_06110	COG1216	Glycosyl transferase, family 2
KR52_06110	COG0438	transferase activity, transferring glycosyl groups
KR52_06115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KR52_06135	COG1160	GTP binding
KR52_06140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KR52_06150	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KR52_06155	COG1799	cell septum assembly
KR52_06160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KR52_06170	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KR52_06190	COG0438	transferase activity, transferring glycosyl groups
KR52_06200	COG1381	Involved in DNA repair and RecF pathway recombination
KR52_06205	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KR52_06210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KR52_06215	COG0321	lipoyl(octanoyl) transferase activity
KR52_06220	COG1022	Amp-dependent synthetase and ligase
KR52_06280	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KR52_06285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KR52_06315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KR52_06320	COG0440	acetolactate synthase activity
KR52_06325	COG2267	carboxylic ester hydrolase activity
KR52_06340	COG0702	epimerase
KR52_06350	COG2226	methyltransferase
KR52_06360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KR52_06365	COG0492	ferredoxin-NADP+ reductase activity
KR52_06395	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KR52_06405	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
KR52_06415	COG3411	Ferredoxin
KR52_06420	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KR52_06425	COG0733	neurotransmitter:sodium symporter activity
KR52_06440	COG0215	cysteine-tRNA ligase activity
KR52_06445	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KR52_06445	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KR52_06455	COG0012	GTP binding
KR52_06480	COG4166	transmembrane transport
KR52_06490	COG0460	homoserine dehydrogenase
KR52_06495	COG2166	iron-sulfur cluster assembly
KR52_06505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KR52_06510	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KR52_06515	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
KR52_06530	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
KR52_06535	COG2010	Cytochrome c
KR52_06545	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KR52_06550	COG3118	belongs to the thioredoxin family
KR52_06555	COG0516	GMP reductase activity
KR52_06560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KR52_06570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KR52_06575	COG0644	oxidoreductase
KR52_06580	COG1543	Belongs to the glycosyl hydrolase 57 family
KR52_06585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KR52_06590	COG0395	ABC-type sugar transport system, permease component
KR52_06620	COG0011	TIGRFAM Protein of
KR52_06630	COG0564	pseudouridine synthase activity
KR52_06635	COG1480	7TM receptor with intracellular HD hydrolase
KR52_06640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KR52_06660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KR52_06685	COG1254	Belongs to the acylphosphatase family
KR52_06690	COG1797	cobyrinic acid a,c-diamide synthase activity
KR52_06700	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KR52_06705	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KR52_06720	COG2205	protein histidine kinase activity
KR52_06735	COG0308	aminopeptidase N
KR52_06780	COG0705	Rhomboid family
KR52_06800	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KR52_06810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KR52_06835	COG0736	holo-[acyl-carrier-protein] synthase activity
KR52_06855	COG2095	MarC family integral membrane protein
KR52_06890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KR52_06935	COG1376	ErfK ybiS ycfS ynhG family protein
KR52_06960	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KR52_06970	COG2197	response regulator
KR52_06975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KR52_06990	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KR52_07005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KR52_07010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KR52_07015	COG0473	3-isopropylmalate dehydrogenase activity
KR52_07020	COG3954	Phosphoribulokinase
KR52_07030	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KR52_07035	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KR52_07045	COG0673	inositol 2-dehydrogenase activity
KR52_07050	COG3588	fructose-bisphosphate aldolase
KR52_07055	COG0191	fructose-bisphosphate aldolase activity
KR52_07065	COG1619	proteins homologs of microcin C7 resistance protein MccF
KR52_07070	COG0047	phosphoribosylformylglycinamidine synthase activity
KR52_07075	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KR52_07090	COG0668	transmembrane transport
KR52_07100	COG0640	Transcriptional regulator
KR52_07145	COG0745	RESPONSE REGULATOR receiver
KR52_07170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KR52_07180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KR52_07195	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KR52_07200	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KR52_07205	COG1429	ligase activity, forming nitrogen-metal bonds
KR52_07235	COG0745	RESPONSE REGULATOR receiver
KR52_07280	COG1132	(ABC) transporter
KR52_07305	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KR52_07310	COG0149	triose-phosphate isomerase activity
KR52_07320	COG1132	(ABC) transporter
KR52_07330	COG1115	amino acid carrier protein
KR52_07340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KR52_07350	COG0799	negative regulation of ribosome biogenesis
KR52_07390	COG0659	secondary active sulfate transmembrane transporter activity
KR52_07400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KR52_07405	COG4597	amino acid ABC transporter
KR52_07410	COG0765	amino acid transport
KR52_07415	COG1126	abc transporter atp-binding protein
KR52_07450	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KR52_07455	COG2873	o-acetylhomoserine
KR52_07525	COG0735	belongs to the Fur family
KR52_07540	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KR52_07580	COG0123	including yeast histone deacetylase and acetoin utilization protein
KR52_07855	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KR52_07865	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KR52_07900	COG0745	RESPONSE REGULATOR receiver
KR52_07910	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KR52_07915	COG0271	Belongs to the BolA IbaG family
KR52_07930	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KR52_07950	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KR52_07965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KR52_07975	COG0513	Belongs to the DEAD box helicase family
KR52_07990	COG0724	RNA recognition motif
KR52_08000	COG1132	(ABC) transporter
KR52_08005	COG0475	glutathione-regulated potassium exporter activity
KR52_08005	COG0589	response to stress
KR52_08025	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KR52_08030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KR52_08040	COG0625	glutathione transferase activity
KR52_08060	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KR52_08065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KR52_08070	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KR52_08075	COG0019	diaminopimelate decarboxylase activity
KR52_08085	COG0542	response to heat
KR52_08090	COG0371	Dehydrogenase
KR52_08095	COG2267	carboxylic ester hydrolase activity
KR52_08105	COG0575	Belongs to the CDS family
KR52_08110	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KR52_08115	COG1982	Orn Lys Arg decarboxylase major
KR52_08120	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KR52_08140	COG0745	RESPONSE REGULATOR receiver
KR52_08145	COG5002	protein histidine kinase activity
KR52_08150	COG1187	pseudouridine synthase activity
KR52_08160	COG1640	4-alpha-glucanotransferase
KR52_08180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KR52_08205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KR52_08210	COG1121	(ABC) transporter
KR52_08235	COG0701	Predicted permease
KR52_08290	COG2010	Cytochrome c
KR52_08300	COG3659	wide pore channel activity
KR52_08320	COG1840	ABC-type Fe3 transport system, periplasmic component
KR52_08325	COG3128	pkhd-type hydroxylase
KR52_08335	COG3659	wide pore channel activity
KR52_08425	COG0405	Gamma-glutamyltransferase
KR52_08475	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KR52_08480	COG1611	Belongs to the LOG family
KR52_08510	COG0668	transmembrane transport
KR52_08715	COG0714	Associated with various cellular activities
KR52_08740	COG0724	RNA recognition motif
KR52_08755	COG2032	superoxide dismutase activity
KR52_08850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KR52_08855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KR52_08860	COG0803	Belongs to the bacterial solute-binding protein 9 family
KR52_08865	COG1121	(ABC) transporter
KR52_08890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KR52_08905	COG1119	ATPase activity
KR52_08940	COG2226	methyltransferase
KR52_09105	COG1201	RNA secondary structure unwinding
KR52_09110	COG1793	dna ligase
KR52_09170	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KR52_09180	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KR52_09220	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KR52_09240	COG0740	serine-type endopeptidase activity
KR52_09245	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KR52_09250	COG1136	(ABC) transporter
KR52_09250	COG0577	efflux transmembrane transporter activity
KR52_09255	COG0469	pyruvate kinase activity
KR52_09270	COG0762	integral membrane protein
KR52_09280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KR52_09285	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KR52_09290	COG0446	pyridine nucleotide-disulphide oxidoreductase
KR52_09440	COG0395	ABC-type sugar transport system, permease component
KR52_09445	COG1175	transmembrane transport
KR52_09450	COG1653	transport
KR52_09455	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KR52_09460	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KR52_09465	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KR52_09470	COG0326	Molecular chaperone. Has ATPase activity
KR52_09480	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KR52_09485	COG0483	inositol monophosphate 1-phosphatase activity
KR52_09500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KR52_09505	COG0581	inorganic phosphate transmembrane transporter activity
KR52_09510	COG0573	inorganic phosphate transmembrane transporter activity
KR52_09515	COG0443	Heat shock 70 kDa protein
KR52_09520	COG0484	heat shock protein binding
KR52_09530	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KR52_09535	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KR52_09540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KR52_09545	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KR52_09545	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KR52_09550	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KR52_09555	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KR52_09590	COG0166	Belongs to the GPI family
KR52_09595	COG0495	leucyl-tRNA aminoacylation
KR52_09605	COG0582	viral genome integration into host DNA
KR52_09635	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KR52_09640	COG1104	cysteine desulfurase activity
KR52_09655	COG2027	D-alanyl-D-alanine carboxypeptidase
KR52_09665	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KR52_09675	COG0322	excinuclease ABC activity
KR52_09685	COG3046	protein related to deoxyribodipyrimidine photolyase
KR52_09710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KR52_09715	COG0646	methionine synthase
KR52_09715	COG1410	methionine synthase
KR52_09740	COG2385	sporulation resulting in formation of a cellular spore
KR52_09755	COG1191	sigma factor activity
KR52_09785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KR52_09790	COG0072	phenylalanine-tRNA ligase activity
KR52_09795	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KR52_09800	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KR52_09805	COG0557	exoribonuclease II activity
KR52_09815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KR52_09850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KR52_09855	COG0739	heme binding
KR52_09870	COG0450	alkyl hydroperoxide reductase
KR52_09875	COG1615	UPF0182 protein
KR52_09880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KR52_09895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KR52_09900	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KR52_09900	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KR52_09915	COG2119	membrane
KR52_09925	COG0557	exoribonuclease II activity
KR52_09930	COG0163	prenyltransferase activity
KR52_09945	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KR52_09950	COG0312	modulator of DNA gyrase
KR52_09960	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KR52_09995	COG0861	Integral membrane protein TerC family
KR52_10050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KR52_10060	COG0793	Belongs to the peptidase S41A family
KR52_10065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KR52_10070	COG1573	uracil-dna glycosylase
KR52_10080	COG0436	Aminotransferase
KR52_10085	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
KR52_10090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KR52_10090	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KR52_10125	COG1836	PFAM Integral membrane protein DUF92
KR52_10145	COG1122	ATPase activity
KR52_10150	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KR52_10165	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KR52_10175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KR52_10295	COG0300	oxidoreductase activity
KR52_10375	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KR52_10385	COG0129	dihydroxy-acid dehydratase activity
KR52_10400	COG0363	glucosamine-6-phosphate deaminase activity
KR52_10405	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KR52_10410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KR52_10415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KR52_10420	COG1494	fructose-1,6-bisphosphatase
KR52_10425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KR52_10440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KR52_10470	COG0826	peptidase U32
KR52_10480	COG0644	oxidoreductase
KR52_10490	COG0751	glycine-tRNA ligase activity
KR52_10495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KR52_10500	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
KR52_10505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KR52_10515	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KR52_10520	COG0052	Belongs to the universal ribosomal protein uS2 family
KR52_10525	COG1216	Glycosyl transferase, family 2
KR52_10555	COG0612	Peptidase, M16
KR52_10560	COG0612	Peptidase, M16
KR52_10575	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KR52_10590	COG0590	tRNA wobble adenosine to inosine editing
KR52_10595	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KR52_10605	COG0174	glutamine synthetase
KR52_10615	COG2226	methyltransferase
KR52_10635	COG0515	serine threonine protein kinase
KR52_10640	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
KR52_10650	COG0628	permease
KR52_10675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KR52_10680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KR52_10685	COG0022	dehydrogenase e1 component
KR52_10685	COG0508	dehydrogenase complex catalyzes the overall conversion of
KR52_10700	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KR52_10705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KR52_10710	COG0792	nuclease activity
KR52_10725	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KR52_10745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KR52_10770	COG0358	DNA primase activity
KR52_10785	COG0632	four-way junction helicase activity
KR52_10790	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KR52_10800	COG0587	DNA-directed DNA polymerase activity
KR52_10805	COG0154	amidase activity
KR52_10815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KR52_10825	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KR52_10835	COG0505	Belongs to the CarA family
KR52_10840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KR52_10845	COG1132	(ABC) transporter
KR52_10860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KR52_10905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KR52_10925	COG2176	DNA-directed DNA polymerase activity
KR52_10930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KR52_10940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KR52_10945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KR52_10950	COG0142	geranyltranstransferase activity
KR52_10955	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KR52_10960	COG0860	N-Acetylmuramoyl-L-alanine amidase
KR52_10965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KR52_10970	COG2045	Belongs to the ComB family
KR52_10975	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KR52_10980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KR52_10990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KR52_10995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KR52_11005	COG0297	glycogen (starch) synthase activity
KR52_11010	COG1376	ErfK ybiS ycfS ynhG family protein
KR52_11015	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KR52_11020	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KR52_11025	COG0681	Belongs to the peptidase S26 family
KR52_11050	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KR52_11055	COG0732	type I restriction modification DNA specificity domain
KR52_11060	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KR52_11070	COG1322	Protein conserved in bacteria
KR52_11145	COG0798	PFAM Bile acid sodium symporter
KR52_11155	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KR52_11160	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
KR52_11185	COG3829	transcription factor binding
KR52_11195	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
KR52_11220	COG1215	transferase activity, transferring glycosyl groups
KR52_11285	COG2814	Major facilitator Superfamily
KR52_11325	COG4251	negative regulation of phosphorylation
KR52_11325	COG3706	GGDEF domain
KR52_11325	COG5001	Diguanylate cyclase
KR52_11325	COG2203	Gaf domain
KR52_11335	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
KR52_11345	COG3300	MHYT domain
KR52_11345	COG5001	Diguanylate cyclase
KR52_11385	COG2124	cytochrome p450
KR52_11410	COG3961	Belongs to the TPP enzyme family
KR52_11435	COG4251	negative regulation of phosphorylation
KR52_11435	COG3706	GGDEF domain
KR52_11435	COG5001	Diguanylate cyclase
KR52_11435	COG2203	Gaf domain
KR52_11440	COG0174	glutamine synthetase
KR52_11450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KR52_11455	COG3706	GGDEF domain
KR52_11470	COG4251	negative regulation of phosphorylation
KR52_11470	COG5001	Diguanylate cyclase
KR52_11470	COG2203	Gaf domain
KR52_11470	COG3706	GGDEF domain
KR52_11680	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KR52_11765	COG0730	response to heat
KR52_11825	COG0385	Bile acid
KR52_11855	COG0180	Tryptophanyl-tRNA synthetase
KR52_11870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KR52_11880	COG0837	glucose binding
KR52_11885	COG0083	homoserine kinase activity
KR52_11890	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR52_11895	COG0339	signal peptide processing
KR52_11910	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KR52_11915	COG1940	carbohydrate kinase activity
KR52_11950	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KR52_11955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KR52_11965	COG3794	PFAM blue (type 1) copper domain protein
KR52_11970	COG2010	Cytochrome c
KR52_12005	COG0542	response to heat
KR52_12015	COG0140	phosphoribosyl-ATP diphosphatase activity
KR52_12015	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KR52_12035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR52_12070	COG2010	Cytochrome c
KR52_12085	COG0159	tryptophan synthase activity
KR52_12105	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KR52_12105	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KR52_12140	COG0418	dihydroorotase activity
KR52_12145	COG0659	secondary active sulfate transmembrane transporter activity
KR52_12170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KR52_12175	COG1845	cytochrome c oxidase, subunit III
KR52_12215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KR52_12235	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KR52_12240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KR52_12255	COG0456	acetyltransferase
KR52_12260	COG1132	(ABC) transporter
KR52_12265	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KR52_12270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KR52_12300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KR52_12315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KR52_12320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KR52_12325	COG2135	peptidase activity
KR52_12335	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KR52_12335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KR52_12375	COG0745	RESPONSE REGULATOR receiver
KR52_12380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KR52_12385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KR52_12390	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KR52_12395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KR52_12400	COG2274	protein secretion by the type I secretion system
KR52_12425	COG0196	riboflavin kinase activity
KR52_12435	COG0352	thiamine-phosphate diphosphorylase activity
KR52_12440	COG2022	thiamine diphosphate biosynthetic process
KR52_12440	COG2104	thiamine diphosphate biosynthetic process
KR52_12455	COG1691	(AIR) carboxylase
KR52_12465	COG0336	Belongs to the RNA methyltransferase TrmD family
KR52_12505	COG0670	Belongs to the BI1 family
KR52_12510	COG1702	phosphate starvation-inducible protein PhoH
KR52_12515	COG0228	four-way junction DNA binding
KR52_12520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KR52_12530	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KR52_12535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR52_12540	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KR52_12540	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KR52_12545	COG0482	sulfurtransferase activity
KR52_12550	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KR52_12580	COG1006	Multisubunit Na H antiporter MnhC subunit
KR52_12585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KR52_12585	COG2111	Na H antiporter
KR52_12615	COG0134	indole-3-glycerol-phosphate synthase activity
KR52_12620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KR52_12625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KR52_12640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KR52_12645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KR52_12650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KR52_12655	COG0285	dihydrofolate synthase activity
KR52_12690	COG4948	Mandelate Racemase Muconate Lactonizing
KR52_12695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KR52_12700	COG1181	Belongs to the D-alanine--D-alanine ligase family
KR52_12715	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KR52_12720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KR52_12725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KR52_12730	COG4956	integral membrane protein (PIN domain superfamily)
KR52_12735	COG0740	serine-type endopeptidase activity
KR52_12740	COG0740	serine-type endopeptidase activity
KR52_12745	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KR52_12755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KR52_12855	COG0752	glycyl-tRNA synthetase alpha subunit
KR52_12890	COG2226	methyltransferase
KR52_12895	COG0107	imidazoleglycerol-phosphate synthase activity
KR52_12905	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KR52_12910	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KR52_12915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KR52_12915	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KR52_12920	COG3695	enzyme binding
KR52_12925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KR52_12940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KR52_12945	COG5002	protein histidine kinase activity
KR52_12980	COG0745	RESPONSE REGULATOR receiver
KR52_12985	COG3850	Histidine kinase
KR52_12985	COG0642	Histidine kinase
KR52_13035	COG0481	GTPase activity
KR52_13045	COG0579	oxidoreductase
KR52_13050	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KR52_13085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KR52_13095	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KR52_13110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KR52_13120	COG0424	maF-like protein
KR52_13130	COG1492	cobalamin metabolic process
KR52_13160	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR52_13165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KR52_13195	COG4451	ribulose bisphosphate carboxylase, small
KR52_13200	COG1850	ribulose-bisphosphate carboxylase activity
KR52_13210	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KR52_13225	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
KR52_13230	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
KR52_13235	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
KR52_13260	COG0730	response to heat
KR52_13265	COG0095	Lipoate-protein ligase
KR52_13270	COG1994	Peptidase M50
KR52_13270	COG0517	IMP dehydrogenase activity
KR52_13275	COG0135	phosphoribosylanthranilate isomerase activity
KR52_13280	COG0302	gtp cyclohydrolase
KR52_13285	COG4221	oxidoreductase activity
KR52_13290	COG0825	malonyl-CoA metabolic process
KR52_13295	COG5322	oxidoreductase activity
KR52_13300	COG3396	Phenylacetate-CoA oxygenase
KR52_13310	COG0539	negative regulation of cytoplasmic translation
KR52_13325	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KR52_13345	COG0028	Belongs to the TPP enzyme family
KR52_13350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KR52_13360	COG2226	methyltransferase
KR52_13375	COG0528	UMP kinase activity
KR52_13380	COG0233	cytoplasmic translational termination
KR52_13405	COG0415	Belongs to the DNA photolyase family
KR52_13420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KR52_13425	COG0768	penicillin binding
KR52_13440	COG0588	phosphoglycerate mutase activity
KR52_13450	COG0681	Belongs to the peptidase S26 family
KR52_13470	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KR52_13480	COG0442	prolyl-tRNA aminoacylation
KR52_13490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KR52_13500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KR52_13530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KR52_13540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KR52_13545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR52_13555	COG0181	hydroxymethylbilane synthase activity
KR52_13575	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KR52_13595	COG0432	Pfam Uncharacterised protein family UPF0047
KR52_13610	COG2154	pterin-4-alpha-carbinolamine dehydratase
KR52_13615	COG0523	cobalamin synthesis protein
KR52_13645	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
KR52_13650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KR52_13670	COG0708	Exodeoxyribonuclease III
KR52_13675	COG0277	FAD linked oxidase domain protein
KR52_13680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KR52_13690	COG0295	cytidine deaminase activity
KR52_13700	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
KR52_13715	COG1666	GTP binding
KR52_13730	COG0857	belongs to the CobB CobQ family
KR52_13740	COG3000	fatty acid hydroxylase
KR52_13740	COG0300	oxidoreductase activity
KR52_13745	COG0024	Methionine aminopeptidase
KR52_13755	COG0335	large ribosomal subunit rRNA binding
KR52_13775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KR52_13795	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KR52_13815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KR52_13830	COG0194	GDP metabolic process
KR52_13840	COG0805	protein transport
KR52_13850	COG0723	plastoquinol--plastocyanin reductase activity
KR52_13855	COG0739	heme binding
KR52_13860	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KR52_13865	COG2875	Belongs to the precorrin methyltransferase family
KR52_13885	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KR52_13890	COG1619	proteins homologs of microcin C7 resistance protein MccF
KR52_13895	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KR52_13910	COG1028	Short-chain dehydrogenase reductase Sdr
KR52_13920	COG0459	protein refolding
KR52_13925	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
KR52_13945	COG0109	protoheme IX farnesyltransferase activity
KR52_13950	COG1612	heme a metabolic process
KR52_13960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KR52_13965	COG1845	cytochrome c oxidase, subunit III
KR52_13995	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KR52_14010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KR52_14015	COG1007	ATP synthesis coupled electron transport
KR52_14020	COG0577	efflux transmembrane transporter activity
KR52_14020	COG1136	(ABC) transporter
KR52_14030	COG2205	protein histidine kinase activity
KR52_14040	COG0745	RESPONSE REGULATOR receiver
KR52_14045	COG0739	heme binding
KR52_14050	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KR52_14050	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KR52_14055	COG0436	Aminotransferase
KR52_14060	COG3118	belongs to the thioredoxin family
KR52_14065	COG1842	Phage shock protein A
KR52_14075	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KR52_14085	COG0697	spore germination
KR52_14090	COG0616	signal peptide processing
KR52_14105	COG0594	ribonuclease P activity
KR52_14115	COG0706	membrane insertase activity
KR52_14125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KR52_14135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KR52_14140	COG0750	zinc metalloprotease
KR52_14145	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KR52_14150	COG1185	polyribonucleotide nucleotidyltransferase activity
KR52_14160	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KR52_14225	COG1970	mechanosensitive ion channel activity
KR52_14330	COG2988	succinylglutamate desuccinylase activity
KR52_14335	COG0435	Glutathione S-transferase
KR52_14345	COG0488	(ABC) transporter
KR52_14360	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KR52_14365	COG3842	ATPase activity
KR52_14370	COG1193	negative regulation of DNA recombination
KR52_14380	COG0113	porphobilinogen synthase activity
KR52_14385	COG0484	heat shock protein binding
KR52_14390	COG4243	Vitamin k epoxide reductase
KR52_14395	COG0659	secondary active sulfate transmembrane transporter activity
KR52_14405	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KR52_14425	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KR52_14430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KR52_14440	COG1012	belongs to the aldehyde dehydrogenase family
KR52_14450	COG0514	ATP-dependent DNA helicase (RecQ)
KR52_14465	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KR52_14470	COG0235	Class ii aldolase
KR52_14475	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)